Gurdyal Besra

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Fox Lisa M; Cox Daryl G; Lockridge Jennifer L; Wang Xiaohua; Chen Xiuxu; Scharf Louise; Trott David L; Ndonye Rachel M; Veerapen Natacha; Besra Gurdyal S; Howell Amy R; Cook Mark E; Adams Erin J; Hildebrand William H; Gumperz Jenny E
Recognition of lyso-phospholipids by human natural killer T lymphocytes.
Driessen Nicole N; Ummels Roy; Maaskant Janneke J; Gurcha Sudagar S; Besra Gurdyal S; Ainge Gary D; Larsen David S; Painter Gavin F; Vandenbroucke-Grauls Christina M J E; Geurtsen Jeroen; Appelmelk Ben J
Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN.
Venkataswamy Manjunatha M; Baena Andres; Goldberg Michael F; Bricard Gabriel; Im Jin S; Chan John; Reddington Faye; Besra Gurdyal S; Jacobs William R; Porcelli Steven A
Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin.

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All Publications

2009: Fox Lisa M; Cox Daryl G; Lockridge Jennifer L; Wang Xiaohua; Chen Xiuxu; Scharf Louise; Trott David L; Ndonye Rachel M; Veerapen Natacha; Besra Gurdyal S; Howell Amy R; Cook Mark E; Adams Erin J; Hildebrand William H; Gumperz Jenny E
Recognition of lyso-phospholipids by human natural killer T lymphocytes.
PLoS biology 2009;7(10):e1000228.
2009: Driessen Nicole N; Ummels Roy; Maaskant Janneke J; Gurcha Sudagar S; Besra Gurdyal S; Ainge Gary D; Larsen David S; Painter Gavin F; Vandenbroucke-Grauls Christina M J E; Geurtsen Jeroen; Appelmelk Ben J
Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN.
Infection and immunity 2009;77(10):4538-47.
2009: Venkataswamy Manjunatha M; Baena Andres; Goldberg Michael F; Bricard Gabriel; Im Jin S; Chan John; Reddington Faye; Besra Gurdyal S; Jacobs William R; Porcelli Steven A
Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1644-56.
2009: Andersen Claire A Swetman; Rosenkrands Ida; Olsen Anja W; Nordly Pernille; Christensen Dennis; Lang Roland; Kirschning Carsten; Gomes Jessica M; Bhowruth Veemal; Minnikin David E; Besra Gurdyal S; Follmann Frank; Andersen Peter; Agger Else Marie
Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2294-302.
2009: Veerapen Natacha; Brigl Manfred; Garg Salil; Cerundolo Vincenzo; Cox Liam R; Brenner Michael B; Besra Gurdyal S
Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.
Bioorganic & medicinal chemistry letters 2009;19(15):4288-91.
2009: Birch Helen L; Alderwick Luke J; Rittmann Doris; Krumbach Karin; Etterich Helga; Grzegorzewicz Anna; McNeil Michael R; Eggeling Lothar; Besra Gurdyal S
Identification of a terminal rhamnopyranosyltransferase (RptA) involved in Corynebacterium glutamicum cell wall biosynthesis.
Journal of bacteriology 2009;191(15):4879-87.
2009: Velmourougane Geetha; Raju Ravinder; Bricard Gabriel; Im Jin S; Besra Gurdyal S; Porcelli Steven A; Howell Amy R
Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH.
Bioorganic & medicinal chemistry letters 2009;19(13):3386-8.
2009: Mishra Arun K; Batt Sarah; Krumbach Karin; Eggeling Lothar; Besra Gurdyal S
Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis.
Journal of bacteriology 2009;191(13):4465-72.
2009: Torrelles Jordi B; DesJardin Lucy E; MacNeil Jessica; Kaufman Thomas M; Kutzbach Beth; Knaup Rose; McCarthy Travis R; Gurcha Sudagar S; Besra Gurdyal S; Clegg Steven; Schlesinger Larry S
Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death.
Glycobiology 2009;19(7):743-55.
2009: Im Jin S; Arora Pooja; Bricard Gabriel; Molano Alberto; Venkataswamy Manjunatha M; Baine Ian; Jerud Elliot S; Goldberg Michael F; Baena Andres; Yu Karl O A; Ndonye Rachel M; Howell Amy R; Yuan Weiming; Cresswell Peter; Chang Young-Tae; Illarionov Petr A; Besra Gurdyal S; Porcelli Steven A
Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation.
Immunity 2009;30(6):888-98.
2009: Kuns Rachel D; Morris Edward S; Macdonald Kelli P A; Markey Kate A; Morris Helen M; Raffelt Neil C; Banovic Tatjana; Don Alistair L J; Rowe Vanessa; Burman Angela C; Clouston Andrew D; Farah Camile; Besra Gurdyal S; Illarionov Petr A; Smyth Mark J; Porcelli Steven A; Hill Geoffrey R
Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration.
Blood 2009;113(23):5999-6010.
2009: Usha Veeraraghavan; Dover Lynn G; Roper David I; Fütterer Klaus; Besra Gurdyal S
Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 4):383-7.
2009: Bessoles Stéphanie; Dudal Sherri; Besra Gurdyal S; Sanchez Françoise; Lafont Virginie
Human CD4+ invariant NKT cells are involved in antibacterial immunity against Brucella suis through CD1d-dependent but CD4-independent mechanisms.
European journal of immunology 2009;39(4):1025-35.
2009: Bhowruth Veemal; Minnikin David E; Agger Else Marie; Andersen Peter; Bramwell Vincent W; Perrie Yvonne; Besra Gurdyal S
Adjuvant properties of a simplified C32 monomycolyl glycerol analogue.
Bioorganic & medicinal chemistry letters 2009;19(7):2029-32.
2009: Guillonneau Carole; Mintern Justine D; Hubert François-Xavier; Hurt Aeron C; Besra Gurdyal S; Porcelli Steven; Barr Ian G; Doherty Peter C; Godfrey Dale I; Turner Stephen J
Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3330-5.
2009: Veyron-Churlet Romain; Molle Virginie; Taylor Rebecca C; Brown Alistair K; Besra Gurdyal S; Zanella-Cléon Isabelle; Fütterer Klaus; Kremer Laurent
The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue.
The Journal of biological chemistry 2009;284(10):6414-24.
2009: Andersen Claire S; Agger Else Marie; Rosenkrands Ida; Gomes Jessica M; Bhowruth Veemal; Gibson Kevin J C; Petersen Rune V; Minnikin David E; Besra Gurdyal S; Andersen Peter
A simple mycobacterial monomycolated glycerol lipid has potent immunostimulatory activity.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):424-32.
2009: Pathak Ashish K; Pathak Vibha; Suling William J; Riordan James R; Gurcha Sudagar S; Besra Gurdyal S; Reynolds Robert C
Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry 2009;17(2):872-81.
2009: Brown Alistair K; Taylor Rebecca C; Bhatt Apoorva; Fütterer Klaus; Besra Gurdyal S
Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases.
PloS one 2009;4(7):e6306.
2009: Al-Balas Qosay; Anthony Nahoum G; Al-Jaidi Bilal; Alnimr Amani; Abbott Grainne; Brown Alistair K; Taylor Rebecca C; Besra Gurdyal S; McHugh Timothy D; Gillespie Stephen H; Johnston Blair F; Mackay Simon P; Coxon Geoffrey D
Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH.
PloS one 2009;4(5):e5617.
2008: De Santo Carmela; Salio Mariolina; Masri S Hajar; Lee Laurel Yong-Hwa; Dong Tao; Speak Anneliese O; Porubsky Stefan; Booth Sarah; Veerapen Natacha; Besra Gurdyal S; Gröne Hermann-Josef; Platt Frances M; Zambon Maria; Cerundolo Vincenzo
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
The Journal of clinical investigation 2008;118(12):4036-48.
2008: Wang Xiaohua; Chen Xiuxu; Rodenkirch Lance; Simonson William; Wernimont Sarah; Ndonye Rachel M; Veerapen Natacha; Gibson Darren; Howell Amy R; Besra Gurdyal S; Painter Gavin F; Huttenlocher Anna; Gumperz Jenny E
Natural killer T-cell autoreactivity leads to a specialized activation state.
Blood 2008;112(10):4128-38.
2008: Leslie David S; Dascher Christopher C; Cembrola Katherine; Townes Maria A; Hava David L; Hugendubler Lynne C; Mueller Elisabetta; Fox Lisa; Roura-Mir Carme; Moody D Branch; Vincent Michael S; Gumperz Jenny E; Illarionov Petr A; Besra Gurdyal S; Reynolds Carol G; Brenner Michael B
Serum lipids regulate dendritic cell CD1 expression and function.
Immunology 2008;125(3):289-301.
2008: Bhatt Apoorva; Brown Alistair K; Singh Albel; Minnikin David E; Besra Gurdyal S
Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones.
Chemistry & biology 2008;15(9):930-9.
2008: Lucas Ricardo; Balbuena Patricia; Errey James C; Squire Marie A; Gurcha Sudagar S; McNeil Michael; Besra Gurdyal S; Davis Benjamin G
Glycomimetic inhibitors of mycobacterial glycosyltransferases: targeting the TB cell wall.
Chembiochem : a European journal of chemical biology 2008;9(14):2197-9.
2008: Fletcher Julie M; Jordan Margaret A; Snelgrove Sarah L; Slattery Robyn M; Dufour François D; Kyparissoudis Konstantinos; Besra Gurdyal S; Godfrey Dale I; Baxter Alan G
Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3400-12.
2008: Birch Helen L; Alderwick Luke J; Bhatt Apoorva; Rittmann Doris; Krumbach Karin; Singh Albel; Bai Yu; Lowary Todd L; Eggeling Lothar; Besra Gurdyal S
Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferase.
Molecular microbiology 2008;69(5):1191-206.
2008: Bhowruth Veemal; Alderwick Luke J; Brown Alistair K; Bhatt Apoorva; Besra Gurdyal S
Tuberculosis: a balanced diet of lipids and carbohydrates.
Biochemical Society transactions 2008;36(Pt 4):555-65.
2008: Mishra Arun K; Klein Christina; Gurcha Sudagar S; Alderwick Luke J; Babu Ponnusamy; Hitchen Paul G; Morris Howard R; Dell Anne; Besra Gurdyal S; Eggeling Lothar
Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB' mutant.
Antonie van Leeuwenhoek 2008;94(2):277-87.
2008: Bhowruth Veemal; Brown Alistair K; Besra Gurdyal S
Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636.
Microbiology (Reading, England) 2008;154(Pt 7):1866-75.
2008: Bessoles Stéphanie; Fouret Frédéric; Dudal Sherri; Besra Gurdyal S; Sanchez Françoise; Lafont Virginie
IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines.
Journal of leukocyte biology 2008;84(1):224-33.
2008: Barral Patricia; Eckl-Dorna Julia; Harwood Naomi E; De Santo Carmela; Salio Mariolina; Illarionov Petr; Besra Gurdyal S; Cerundolo Vincenzo; Batista Facundo D
B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(24):8345-50.
2008: Leadbetter Elizabeth A; Brigl Manfred; Illarionov Petr; Cohen Nadia; Luteran Megan C; Pillai Shiv; Besra Gurdyal S; Brenner Michael B
NK T cells provide lipid antigen-specific cognate help for B cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(24):8339-44.
2008: Sprengers Dave; Sillé Fenna C M; Derkow Katja; Besra Gurdyal S; Janssen Harry L A; Schott Eckart; Boes Marianne
Critical role for CD1d-restricted invariant NKT cells in stimulating intrahepatic CD8 T-cell responses to liver antigen.
Gastroenterology 2008;134(7):2132-43.
2008: Dao Dee N; Sweeney Kari; Hsu Tsungda; Gurcha Sudagar S; Nascimento Ivan P; Roshevsky Dan; Besra Gurdyal S; Chan John; Porcelli Steven A; Jacobs William R
Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.
PLoS pathogens 2008;4(6):e1000081.
2008: Mishra Arun K; Alderwick Luke J; Rittmann Doris; Wang Cindy; Bhatt Apoorva; Jacobs William R; Takayama Kuni; Eggeling Lothar; Besra Gurdyal S
Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.
Molecular microbiology 2008;68(6):1595-613.
2008: Nigou Jérôme; Vasselon Thierry; Ray Aurélie; Constant Patricia; Gilleron Martine; Besra Gurdyal S; Sutcliffe Iain; Tiraby Gérard; Puzo Germain
Mannan chain length controls lipoglycans signaling via and binding to TLR2.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6696-702.
2008: Silk Jonathan D; Salio Mariolina; Reddy B Gopal; Shepherd Dawn; Gileadi Uzi; Brown James; Masri S Hajar; Polzella Paolo; Ritter Gerd; Besra Gurdyal S; Jones E Yvonne; Schmidt Richard R; Cerundolo Vincenzo
Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6452-6.
2008: Dover Lynn G; Bhatt Apoorva; Bhowruth Veemal; Willcox Benjamin E; Besra Gurdyal S
New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections.
Expert review of vaccines 2008;7(4):481-97.
2008: Im Jin S; Kang Tae-Jin; Lee Seong-Beom; Kim Chi-Hong; Lee Sang-Haak; Venkataswamy Manjunatha M; Serfass Evan R; Chen Bing; Illarionov Petr A; Besra Gurdyal S; Jacobs William R; Chae Gue-Tae; Porcelli Steven A
Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections.
Clinical immunology (Orlando, Fla.) 2008;127(2):214-24.
2008: Garton Natalie J; Waddell Simon J; Sherratt Anna L; Lee Su-Min; Smith Rebecca J; Senner Claire; Hinds Jason; Rajakumar Kumar; Adegbola Richard A; Besra Gurdyal S; Butcher Philip D; Barer Michael R
Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum.
PLoS medicine 2008;5(4):e75.
2008: Molano Alberto; Illarionov Petr A; Besra Gurdyal S; Putterman Chaim; Porcelli Steven A
Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase.
Immunology letters 2008;117(1):81-90.
2008: Alderwick Luke J; Dover Lynn G; Veerapen Natacha; Gurcha Sudagar S; Kremer Laurent; Roper David L; Pathak Ashish K; Reynolds Robert C; Besra Gurdyal S
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.
Protein expression and purification 2008;58(2):332-41.
2008: Hu Yanmin; Henderson Brian; Lund Peter A; Tormay Peter; Ahmed M Tabish; Gurcha Sudagar S; Besra Gurdyal S; Coates Anthony R M
A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection.
Infection and immunity 2008;76(4):1535-46.
2008: Usha Veeraraghavan; Dover Lynn G; Roper David L; Besra Gurdyal S
Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization.
FEMS microbiology letters 2008;280(1):57-63.
2008: Stirnemann Kathrin; Romero Jackeline F; Baldi Lucia; Robert Bruno; Cesson Valérie; Besra Gurdyal S; Zauderer Maurice; Wurm Florian; Corradin Giampietro; Mach Jean-Pierre; Macdonald H Robson; Donda Alena
Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice.
The Journal of clinical investigation 2008;118(3):994-1005.
2008: Denkberg Galit; Stronge Victoria S; Zahavi Efrat; Pittoni Paola; Oren Ravit; Shepherd Dawn; Salio Mariolina; McCarthy Corinna; Illarionov Petr A; van der Merwe Anton; Besra Gurdyal S; Dellabona Paolo; Casorati Giulia; Cerundolo Vincenzo; Reiter Yoram
Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules.
European journal of immunology 2008;38(3):829-40.
2008: Gratraud Paul; Surolia Namita; Besra Gurdyal S; Surolia Avadhesha; Kremer Laurent
Antimycobacterial Activity and Mechanism of Action of NAS-91.
Antimicrobial agents and chemotherapy 2008;52(3):1162-6.
2008: Molle Virginie; Reynolds Robert C; Alderwick Luke J; Besra Gurdyal S; Cozzone Alain J; Fütterer Klaus; Kremer Laurent
EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR.
The Biochemical journal 2008;410(2):309-17.
2008: Tam Pui-Hang; Besra Gurdyal S; Lowary Todd L
Exploring the substrate specificity of a mycobacterial polyprenol monophosphomannose-dependent alpha-(1-->6)-mannosyltransferase.
Chembiochem : a European journal of chemical biology 2008;9(2):267-78.
2008: Mishra Kanhu C; de Chastellier Chantal; Narayana Yeddula; Bifani Pablo; Brown Alistair K; Besra Gurdyal S; Katoch Vishwa M; Joshi Beenu; Balaji Kithiganahalli N; Kremer Laurent
Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY.
Infection and immunity 2008;76(1):127-40.
2008: Niemeyer Marcus; Darmoise Alexandre; Mollenkopf Hans-Joachim; Hahnke Karin; Hurwitz Robert; Besra Gurdyal S; Schaible Ulrich E; Kaufmann Stefan H E
Natural killer T-cell characterization through gene expression profiling: an account of versatility bridging T helper type 1 (Th1), Th2 and Th17 immune responses.
Immunology 2008;123(1):45-56.
2008: Croudace Joanne E; Curbishley Stuart M; Mura Manuela; Willcox Carrie R; Illarionov Petr A; Besra Gurdyal S; Adams David H; Lammas David A
Identification of distinct human invariant natural killer T-cell response phenotypes to alpha-galactosylceramide.
BMC immunology 2008;9():71.
2008: Hershkovitz Israel; Donoghue Helen D; Minnikin David E; Besra Gurdyal S; Lee Oona Y-C; Gernaey Angela M; Galili Ehud; Eshed Vered; Greenblatt Charles L; Lemma Eshetu; Bar-Gal Gila Kahila; Spigelman Mark
Detection and molecular characterization of 9,000-year-old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern Mediterranean.
PloS one 2008;3(10):e3426.
2007: Salio Mariolina; Speak Anneliese O; Shepherd Dawn; Polzella Paolo; Illarionov Petr A; Veerapen Natacha; Besra Gurdyal S; Platt Frances M; Cerundolo Vincenzo
Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(51):20490-5.
2007: Brown Alistair K; Bhatt Apoorva; Singh Albel; Saparia Elesh; Evans Alex F; Besra Gurdyal S
Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex.
Microbiology (Reading, England) 2007;153(Pt 12):4166-73.
2007: Chen Xiuxu; Wang Xiaohua; Besra Gurdyal S; Gumperz Jenny E
Modulation of CD1d-restricted NKT cell responses by CD4.
Journal of leukocyte biology 2007;82(6):1455-65.
2007: McNab Finlay W; Pellicci Daniel G; Field Kenneth; Besra Gurdyal; Smyth Mark J; Godfrey Dale I; Berzins Stuart P
Peripheral NK1.1 NKT cells are mature and functionally distinct from their thymic counterparts.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6630-7.
2007: Alderwick L J; Birch H L; Mishra A K; Eggeling L; Besra G S
Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new drug targets.
Biochemical Society transactions 2007;35(Pt 5):1325-8.
2007: Li Qian; Ndonye Rachel M; Illarionov Petr A; Yu Karl O A; Jerud Elliot S; Diaz Kristine; Bricard Gabriel; Porcelli Steven A; Besra Gurdyal S; Chang Young-Tae; Howell Amy R
Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries.
Journal of combinatorial chemistry 2007;9(6):1084-93.
2007: Al-Sayyed Ban; Piperdi Sajida; Yuan Xinni; Li Anping; Besra Gurdyal S; Jacobs William R; Casadevall Arturo; Glatman-Freedman Aharona
Monoclonal antibodies to Mycobacterium tuberculosis CDC 1551 reveal subcellular localization of MPT51.
Tuberculosis (Edinburgh, Scotland) 2007;87(6):489-97.
2007: Vafiadi Christina; Topakas Evangelos; Alderwick Luke J; Besra Gurdyal S; Christakopoulos Paul
Chemoenzymatic synthesis of feruloyl D-arabinose as a potential anti-mycobacterial agent.
Biotechnology letters 2007;29(11):1771-4.
2007: Ghadbane Hemza; Brown Alistair K; Kremer Laurent; Besra Gurdyal S; Fütterer Klaus
Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT).
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 10):831-5.
2007: Brown Alistair K; Papaemmanouil Athina; Bhowruth Veemal; Bhatt Apoorva; Dover Lynn G; Besra Gurdyal S
Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.
Microbiology (Reading, England) 2007;153(Pt 10):3314-22.
2007: Bhowruth Veemal; Brown Alistair K; Senior Suzanne J; Snaith John S; Besra Gurdyal S
Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library.
Bioorganic & medicinal chemistry letters 2007;17(20):5643-6.
2007: Mishra Arun K; Alderwick Luke J; Rittmann Doris; Tatituri Raju V V; Nigou Jerome; Gilleron Martine; Eggeling Lothar; Besra Gurdyal S
Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis.
Molecular microbiology 2007;65(6):1503-17.
2007: Teng Michele W L; Westwood Jennifer A; Darcy Phillip K; Sharkey Janelle; Tsuji Moriya; Franck Richard W; Porcelli Steven A; Besra Gurdyal S; Takeda Kazuyoshi; Yagita Hideo; Kershaw Michael H; Smyth Mark J
Combined natural killer T-cell based immunotherapy eradicates established tumors in mice.
Cancer research 2007;67(15):7495-504.
2007: Tatituri Raju Venkata Veera; Alderwick Luke J; Mishra Arun K; Nigou Jerome; Gilleron Martine; Krumbach Karin; Hitchen Paul; Giordano Assunta; Morris Howard R; Dell Anne; Eggeling Lothar; Besra Gurdyal S
Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant.
Microbiology (Reading, England) 2007;153(Pt 8):2621-9.
2007: Kendall Sharon L; Withers Mike; Soffair Catherine N; Moreland Nicole J; Gurcha Sudagar; Sidders Ben; Frita Rosangela; Ten Bokum Annemieke; Besra Gurdyal S; Lott J Shaun; Stoker Neil G
A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis.
Molecular microbiology 2007;65(3):684-99.
2007: Pathak Ashish K; Pathak Vibha; Riordan James R; Suling William J; Gurcha Sudagar S; Besra Gurdyal S; Reynolds Robert C
Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 2007;17(16):4527-30.
2007: Pathak Ashish K; Pathak Vibha; Seitz Lainne; Gurcha Sudagar S; Besra Gurdyal S; Riordan James M; Reynolds Robert C
Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry 2007;15(16):5629-50.
2007: Borg Natalie A; Wun Kwok S; Kjer-Nielsen Lars; Wilce Matthew C J; Pellicci Daniel G; Koh Ruide; Besra Gurdyal S; Bharadwaj Mandvi; Godfrey Dale I; McCluskey James; Rossjohn Jamie
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.
Nature 2007;448(7149):44-9.
2007: Gande Roland; Dover Lynn G; Krumbach Karin; Besra Gurdyal S; Sahm Hermann; Oikawa Tadao; Eggeling Lothar
The two carboxylases of Corynebacterium glutamicum essential for fatty acid and mycolic acid synthesis.
Journal of bacteriology 2007;189(14):5257-64.
2007: Bhatt Apoorva; Molle Virginie; Besra Gurdyal S; Jacobs William R; Kremer Laurent
The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development.
Molecular microbiology 2007;64(6):1442-54.
2007: Dover Lynn G; Alderwick Luke J; Brown Alistair K; Futterer Klaus; Besra Gurdyal S
Regulation of cell wall synthesis and growth.
Current molecular medicine 2007;7(3):247-76.
2007: McCarthy Corinna; Shepherd Dawn; Fleire Sebastian; Stronge Victoria S; Koch Michael; Illarionov Petr A; Bossi Giovanna; Salio Mariolina; Denkberg Galit; Reddington Faye; Tarlton Andrea; Reddy B Gopal; Schmidt Richard R; Reiter Yoram; Griffiths Gillian M; van der Merwe P Anton; Besra Gurdyal S; Jones E Yvonne; Batista Facundo D; Cerundolo Vincenzo
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.
The Journal of experimental medicine 2007;204(5):1131-44.
2007: Chen Xiuxu; Wang Xiaohua; Keaton Jason M; Reddington Faye; Illarionov Petr A; Besra Gurdyal S; Gumperz Jenny E
Distinct endosomal trafficking requirements for presentation of autoantigens and exogenous lipids by human CD1d molecules.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6181-90.
2007: Bacon Joanna; Dover Lynn G; Hatch Kim A; Zhang Yi; Gomes Jessica M; Kendall Sharon; Wernisch Lorenz; Stoker Neil G; Butcher Philip D; Besra Gurdyal S; Marsh Philip D
Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester.
Microbiology (Reading, England) 2007;153(Pt 5):1435-44.
2007: Yu Karl O A; Im Jin S; Illarionov Petr A; Ndonye Rachel M; Howell Amy R; Besra Gurdyal S; Porcelli Steven A
Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d.
Journal of immunological methods 2007;323(1):11-23.
2007: Seidel Mathias; Alderwick Luke J; Birch Helen L; Sahm Hermann; Eggeling Lothar; Besra Gurdyal S
Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum and Mycobacterium tuberculosis.
The Journal of biological chemistry 2007;282(20):14729-40.
2007: Hegde Subramanya; Chen Xiuxu; Keaton Jason M; Reddington Faye; Besra Gurdyal S; Gumperz Jenny E
NKT cells direct monocytes into a DC differentiation pathway.
Journal of leukocyte biology 2007;81(5):1224-35.
2007: Yuan Weiming; Qi Xiaoyang; Tsang Pansy; Kang Suk-Jo; Illarionov Petr A; Besra Gurdyal S; Gumperz Jenny; Cresswell Peter
Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5551-6.
2007: Bhatt Apoorva; Fujiwara Nagatoshi; Bhatt Kiranmai; Gurcha Sudagar S; Kremer Laurent; Chen Bing; Chan John; Porcelli Steven A; Kobayashi Kazuo; Besra Gurdyal S; Jacobs William R
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5157-62.
2007: Coquet Jonathan M; Kyparissoudis Konstantinos; Pellicci Daniel G; Besra Gurdyal; Berzins Stuart P; Smyth Mark J; Godfrey Dale I
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2827-34.
2007: Ren Huiping; Dover Lynn G; Islam Salim T; Alexander David C; Chen Jeffrey M; Besra Gurdyal S; Liu Jun
Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum.
Molecular microbiology 2007;63(5):1345-59.
2007: Dover Lynn G; Alahari Anuradha; Gratraud Paul; Gomes Jessica M; Bhowruth Veemal; Reynolds Robert C; Besra Gurdyal S; Kremer Laurent
EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.
Antimicrobial agents and chemotherapy 2007;51(3):1055-63.
2007: Bhatt Kiranmai; Gurcha Sudagar S; Bhatt Apoorva; Besra Gurdyal S; Jacobs William R
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
Microbiology (Reading, England) 2007;153(Pt 2):513-20.
2007: Forestier Claire; Takaki Toshiyuki; Molano Alberto; Im Jin S; Baine Ian; Jerud Elliot S; Illarionov Petr; Ndonye Rachel; Howell Amy R; Santamaria Pere; Besra Gurdyal S; Dilorenzo Teresa P; Porcelli Steven A
Improved outcomes in NOD mice treated with a novel Th2 cytokine-biasing NKT cell activator.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1415-25.
2007: Tatituri Raju V V; Illarionov Petr A; Dover Lynn G; Nigou Jerome; Gilleron Martine; Hitchen Paul; Krumbach Karin; Morris Howard R; Spencer Neil; Dell Anne; Eggeling Lothar; Besra Gurdyal S
Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis.
The Journal of biological chemistry 2007;282(7):4561-72.
2007: Sridharan Sudharsan; Wang Lei; Brown Alistair K; Dover Lynn G; Kremer Laurent; Besra Gurdyal S; Sacchettini James C
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).
Journal of molecular biology 2007;366(2):469-80.
2007: Seidel Mathias; Alderwick Luke J; Sahm Hermann; Besra Gurdyal S; Eggeling Lothar
Topology and mutational analysis of the single Emb arabinofuranosyltransferase of Corynebacterium glutamicum as a model of Emb proteins of Mycobacterium tuberculosis.
Glycobiology 2007;17(2):210-9.
2007: Wang Feng; Langley Robert; Gulten Gulcin; Dover Lynn G; Besra Gurdyal S; Jacobs William R; Sacchettini James C
Mechanism of thioamide drug action against tuberculosis and leprosy.
The Journal of experimental medicine 2007;204(1):73-8.
2007: Gobec Stanislav; Plantan Ivan; Mravljak Janez; Svajger Urban; Wilson Rosalind A; Besra Gurdyal S; Soares Sousana L; Appelberg Rui; Kikelj Danijel
Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall.
European journal of medicinal chemistry 2007;42(1):54-63.
2007: Alahari Anuradha; Trivelli Xavier; Guérardel Yann; Dover Lynn G; Besra Gurdyal S; Sacchettini James C; Reynolds Robert C; Coxon Geoffrey D; Kremer Laurent
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.
PloS one 2007;2(12):e1343.
2007: Brown Alistair K; Meng Guoyu; Ghadbane Hemza; Scott David J; Dover Lynn G; Nigou Jérôme; Besra Gurdyal S; Fütterer Klaus
Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+.
BMC structural biology 2007;7():55.
2007: Bhowruth Veemal; Dover Lynn G; Besra Gurdyal S
Tuberculosis chemotherapy: recent developments and future perspectives.
Progress in medicinal chemistry 2007;45():169-203.
2006: Paduraru Crina; Spiridon Laurentiu; Yuan Weiming; Bricard Gabriel; Valencia Xavier; Porcelli Steven A; Illarionov Petr A; Besra Gurdyal S; Petrescu Stefana M; Petrescu Andrei-Jose; Cresswell Peter
An N-linked glycan modulates the interaction between the CD1d heavy chain and beta 2-microglobulin.
The Journal of biological chemistry 2006;281(52):40369-78.
2006: Kim Peter J; Pai Sung-Yun; Brigl Manfred; Besra Gurdyal S; Gumperz Jenny; Ho I-Cheng
GATA-3 regulates the development and function of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6650-9.
2006: Alderwick Luke J; Dover Lynn G; Seidel Mathias; Gande Roland; Sahm Hermann; Eggeling Lothar; Besra Gurdyal S
Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-D-arabinose metabolism.
Glycobiology 2006;16(11):1073-81.
2006: Im Jin S; Tapinos Nikos; Chae Gue-Tae; Illarionov Petr A; Besra Gurdyal S; DeVries George H; Modlin Robert L; Sieling Peter A; Rambukkana Anura; Porcelli Steven A
Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5226-35.
2006: Gadola Stephan D; Silk Jonathan D; Jeans Aruna; Illarionov Petr A; Salio Mariolina; Besra Gurdyal S; Dwek Raymond; Butters Terry D; Platt Frances M; Cerundolo Vincenzo
Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.
The Journal of experimental medicine 2006;203(10):2293-303.
2006: Szatmari Istvan; Pap Attila; Rühl Ralph; Ma Jiang-Xing; Illarionov Petr A; Besra Gurdyal S; Rajnavolgyi Eva; Dezso Balazs; Nagy Laszlo
PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells.
The Journal of experimental medicine 2006;203(10):2351-62.
2006: Molle Virginie; Brown Alistair K; Besra Gurdyal S; Cozzone Alain J; Kremer Laurent
The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.
The Journal of biological chemistry 2006;281(40):30094-103.
2006: Chen Yi-Guang; Chen Jing; Osborne Melissa A; Chapman Harold D; Besra Gurdyal S; Porcelli Steven A; Leiter Edward H; Wilson S Brian; Serreze David V
CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):2939-47.
2006: Usha Veeraraghavan; Dover Lynn G; Roper David L; Lloyd Adrian J; Besra Gurdyal S
Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase.
FEMS microbiology letters 2006;262(1):39-47.
2006: Bhowruth Veemal; Brown Alistair K; Reynolds Robert C; Coxon Geoffrey D; Mackay Simon P; Minnikin David E; Besra Gurdyal S
Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 2006;16(18):4743-7.
2006: Kovac Andreja; Wilson Rosalind A; Besra Gurdyal S; Filipic Metka; Kikelj Danijel; Gobec Stanislav
New lipophilic phthalimido- and 3-phenoxybenzyl sulfonates: inhibition of antigen 85C mycolyltransferase activity and cytotoxicity.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):391-7.
2006: Cheng Tan-Yun; Relloso Miguel; Van Rhijn Ildiko; Young David C; Besra Gurdyal S; Briken Volker; Zajonc Dirk M; Wilson Ian A; Porcelli Steven; Moody D Branch
Role of lipid trimming and CD1 groove size in cellular antigen presentation.
The EMBO journal 2006;25(13):2989-99.
2006: Alderwick Luke J; Seidel Mathias; Sahm Hermann; Besra Gurdyal S; Eggeling Lothar
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis.
The Journal of biological chemistry 2006;281(23):15653-61.
2006: Joe Maju; Sun Daniel; Taha Hashem; Completo Gladys C; Croudace Joanne E; Lammas David A; Besra Gurdyal S; Lowary Todd L
The 5-deoxy-5-methylthio-xylofuranose residue in mycobacterial lipoarabinomannan. absolute stereochemistry, linkage position, conformation, and immunomodulatory activity.
Journal of the American Chemical Society 2006;128(15):5059-72.
2006: Van Rhijn Ildiko; Koets Ad P; Im Jin Seon; Piebes Diewertje; Reddington Faye; Besra Gurdyal S; Porcelli Steven A; van Eden Willem; Rutten Victor P M G
The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4888-93.
2006: Brigl Manfred; van den Elzen Peter; Chen Xiuxu; Meyers Jennifer Hartt; Wu Douglass; Wong Chi-Huey; Reddington Faye; Illarianov Petr A; Besra Gurdyal S; Brenner Michael B; Gumperz Jenny E
Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3625-34.
2006: Kjer-Nielsen Lars; Borg Natalie A; Pellicci Daniel G; Beddoe Travis; Kostenko Lyudmila; Clements Craig S; Williamson Nicholas A; Smyth Mark J; Besra Gurdyal S; Reid Hugh H; Bharadwaj Mandvi; Godfrey Dale I; Rossjohn Jamie; McCluskey James
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.
The Journal of experimental medicine 2006;203(3):661-73.
2006: Alderwick Luke J; Molle Virginie; Kremer Laurent; Cozzone Alain J; Dafforn Timothy R; Besra Gurdyal S; Fütterer Klaus
Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2558-63.
2006: Anderton Matthew C; Bhakta Sanjib; Besra Gurdyal S; Jeavons Peter; Eltis Lindsay D; Sim Edith
Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG.
Molecular microbiology 2006;59(1):181-92.
2005: Burguière Adeline; Hitchen Paul G; Dover Lynn G; Kremer Laurent; Ridell Malin; Alexander David C; Liu Jun; Morris Howard R; Minnikin David E; Dell Anne; Besra Gurdyal S
LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum.
The Journal of biological chemistry 2005;280(51):42124-33.
2005: van den Elzen Peter; Garg Salil; León Luis; Brigl Manfred; Leadbetter Elizabeth A; Gumperz Jenny E; Dascher Chris C; Cheng Tan-Yun; Sacks Frank M; Illarionov Petr A; Besra Gurdyal S; Kent Sally C; Moody D Branch; Brenner Michael B
Apolipoprotein-mediated pathways of lipid antigen presentation.
Nature 2005;437(7060):906-10.
2005: Sköld Markus; Xiong Xiaowei; Illarionov Petr A; Besra Gurdyal S; Behar Samuel M
Interplay of cytokines and microbial signals in regulation of CD1d expression and NKT cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3584-93.
2005: Brown Alistair K; Sridharan Sudharsan; Kremer Laurent; Lindenberg Sandra; Dover Lynn G; Sacchettini James C; Besra Gurdyal S
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
The Journal of biological chemistry 2005;280(37):32539-47.
2005: Alderwick Luke J; Radmacher Eva; Seidel Mathias; Gande Roland; Hitchen Paul G; Morris Howard R; Dell Anne; Sahm Hermann; Eggeling Lothar; Besra Gurdyal S
Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core.
The Journal of biological chemistry 2005;280(37):32362-71.
2005: Kremer Laurent; de Chastellier Chantal; Dobson Gary; Gibson Kevin J C; Bifani Pablo; Balor Stéphanie; Gorvel Jean-Pierre; Locht Camille; Minnikin David E; Besra Gurdyal S
Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol.
Molecular microbiology 2005;57(4):1113-26.
2005: Koch Michael; Stronge Victoria S; Shepherd Dawn; Gadola Stephan D; Mathew Bini; Ritter Gerd; Fersht Alan R; Besra Gurdyal S; Schmidt Richard R; Jones E Yvonne; Cerundolo Vincenzo
The crystal structure of human CD1d with and without alpha-galactosylceramide.
Nature immunology 2005;6(8):819-26.
2005: Gibson Kevin J C; Gilleron Martine; Constant Patricia; Sichi Bénédicte; Puzo Germain; Besra Gurdyal S; Nigou Jérôme
A lipomannan variant with strong TLR-2-dependent pro-inflammatory activity in Saccharothrix aerocolonigenes.
The Journal of biological chemistry 2005;280(31):28347-56.
2005: Forestier Claire; Molano Alberto; Im Jin Seon; Dutronc Yves; Diamond Betty; Davidson Anne; Illarionov Petr A; Besra Gurdyal S; Porcelli Steven A
Expansion and hyperactivity of CD1d-restricted NKT cells during the progression of systemic lupus erythematosus in (New Zealand Black x New Zealand White)F1 mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):763-70.
2005: Radmacher Eva; Alderwick Luke J; Besra Gurdyal S; Brown Alistair K; Gibson Kevin J C; Sahm Hermann; Eggeling Lothar
Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum.
Microbiology (Reading, England) 2005;151(Pt 7):2421-7.
2005: Lang Gillian A; Illarionov Petr A; Glatman-Freedman Aharona; Besra Gurdyal S; Lang Mark L
BCR targeting of biotin-{alpha}-galactosylceramide leads to enhanced presentation on CD1d and requires transport of BCR to CD1d-containing endocytic compartments.
International immunology 2005;17(7):899-908.
2005: Burguière Adeline; Hitchen Paul G; Dover Lynn G; Dell Anne; Besra Gurdyal S
Altered expression profile of mycobacterial surface glycopeptidolipids following treatment with the antifungal azole inhibitors econazole and clotrimazole.
Microbiology (Reading, England) 2005;151(Pt 6):2087-95.
2005: Radmacher Eva; Stansen Kathrin C; Besra Gurdyal S; Alderwick Luke J; Maughan William N; Hollweg Günter; Sahm Hermann; Wendisch Volker F; Eggeling Lothar
Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits L-glutamate efflux of Corynebacterium glutamicum.
Microbiology (Reading, England) 2005;151(Pt 5):1359-68.
2005: Hotter Grant S; Wards Barry J; Mouat Pania; Besra Gurdyal S; Gomes Jessica; Singh Monica; Bassett Shalome; Kawakami Pamela; Wheeler Paul R; de Lisle Geoffrey W; Collins Desmond M
Transposon mutagenesis of Mb0100 at the ppe1-nrp locus in Mycobacterium bovis disrupts phthiocerol dimycocerosate (PDIM) and glycosylphenol-PDIM biosynthesis, producing an avirulent strain with vaccine properties at least equal to those of M. bovis BCG.
Journal of bacteriology 2005;187(7):2267-77.
2005: Roura-Mir Carme; Catálfamo Marta; Cheng Tan-Yun; Marqusee Ellen; Besra Gurdyal S; Jaraquemada Dolores; Moody D Branch
CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3773-80.
2005: Yu Karl O A; Im Jin S; Molano Alberto; Dutronc Yves; Illarionov Petr A; Forestier Claire; Fujiwara Nagatoshi; Arias Isa; Miyake Sachiko; Yamamura Takashi; Chang Young-Tae; Besra Gurdyal S; Porcelli Steven A
Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3383-8.
2005: Cociorva Oana M; Gurcha Sudagar S; Besra Gurdyal S; Lowary Todd L
Oligosaccharides as inhibitors of mycobacterial arabinosyltransferases. Di- and trisaccharides containing C-3 modified arabinofuranosyl residues.
Bioorganic & medicinal chemistry 2005;13(4):1369-79.
2005: Subramaniam Vinodhkumar; Gurcha Sudagar S; Besra Gurdyal S; Lowary Todd L
Modified mannose disaccharides as substrates and inhibitors of a polyprenol monophosphomannose-dependent alpha-(1-->6)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesis.
Bioorganic & medicinal chemistry 2005;13(4):1083-94.
2005: Chen Yi-Guang; Choisy-Rossi Caroline-Morgane; Holl Thomas M; Chapman Harold D; Besra Gurdyal S; Porcelli Steven A; Shaffer Daniel J; Roopenian Derry; Wilson S Brian; Serreze David V
Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1196-204.
2005: Takayama Kuni; Wang Cindy; Besra Gurdyal S
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.
Clinical microbiology reviews 2005;18(1):81-101.
2005: Waddell S J; Chung G A; Gibson K J C; Everett M J; Minnikin D E; Besra G S; Butcher P D
Inactivation of polyketide synthase and related genes results in the loss of complex lipids in Mycobacterium tuberculosis H37Rv.
Letters in applied microbiology 2005;40(3):201-6.
2004: Matsunaga Isamu; Bhatt Apoorva; Young David C; Cheng Tan-Yun; Eyles Stephen J; Besra Gurdyal S; Briken Volker; Porcelli Steven A; Costello Catherine E; Jacobs William R; Moody D Branch
Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells.
The Journal of experimental medicine 2004;200(12):1559-69.
2004: Amprey Joseph L; Im Jin S; Turco Salvatore J; Murray Henry W; Illarionov Petr A; Besra Gurdyal S; Porcelli Steven A; Späth Gerald F
A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan.
The Journal of experimental medicine 2004;200(7):895-904.
2004: Gande Roland; Gibson Kevin J C; Brown Alistair K; Krumbach Karin; Dover Lynn G; Sahm Hermann; Shioyama Susumu; Oikawa Tadao; Besra Gurdyal S; Eggeling Lothar
Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.
The Journal of biological chemistry 2004;279(43):44847-57.
2004: Van Rhijn Ildiko; Young David C; Im Jin Seon; Levery Steven B; Illarionov Petr A; Besra Gurdyal S; Porcelli Steven A; Gumperz Jenny; Cheng Tan-Yun; Moody D Branch
CD1d-restricted T cell activation by nonlipidic small molecules.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(37):13578-83.
2004: Cren Sylvaine; Gurcha Sudagar S; Blake Alexander J; Besra Gurdyal S; Thomas Neil R
Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase--a key enzyme in M. tuberculosis cell wall biosynthesis.
Organic & biomolecular chemistry 2004;2(17):2418-20.
2004: Guy Mark R; Illarionov Petr A; Gurcha Sudagar S; Dover Lynn G; Gibson Kevin J C; Smith Paul W; Minnikin David E; Besra Gurdyal S
Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.
The Biochemical journal 2004;382(Pt 3):905-12.
2004: Sidobre Stéphane; Hammond Kirsten J L; Bénazet-Sidobre Lise; Maltsev Sergei D; Richardson Stewart K; Ndonye Rachel M; Howell Amy R; Sakai Teruyuki; Besra Gurdyal S; Porcelli Steven A; Kronenberg Mitchell
The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12254-9.
2004: Ronning Donald R; Vissa Varalakshmi; Besra Gurdyal S; Belisle John T; Sacchettini James C
Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity.
The Journal of biological chemistry 2004;279(35):36771-7.
2004: Dover Lynn G; Corsino Patrick E; Daniels Ian R; Cocklin Sarah L; Tatituri Vijaya; Besra Gurdyal S; Fütterer Klaus
Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance.
Journal of molecular biology 2004;340(5):1095-105.
2004: Briken Volker; Porcelli Steven A; Besra Gurdyal S; Kremer Laurent
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
Molecular microbiology 2004;53(2):391-403.
2004: Lang Gillian A; Maltsev Sergei D; Besra Gurdyal S; Lang Mark L
Presentation of alpha-galactosylceramide by murine CD1d to natural killer T cells is facilitated by plasma membrane glycolipid rafts.
Immunology 2004;112(3):386-96.
2004: Gobec Stanislav; Plantan Ivan; Mravljak Janez; Wilson Rosalind A; Besra Gurdyal S; Kikelj Danijel
Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall.
Bioorganic & medicinal chemistry letters 2004;14(13):3559-62.
2004: Bhakta Sanjib; Besra Gurdyal S; Upton Anna M; Parish Tanya; Sholto-Douglas-Vernon Carolyn; Gibson Kevin J C; Knutton Stuart; Gordon Siamon; DaSilva Rosangela P; Anderton Matthew C; Sim Edith
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target.
The Journal of experimental medicine 2004;199(9):1191-9.
2004: Dover Lynn G; Cerdeño-Tárraga Ana M; Pallen Mark J; Parkhill Julian; Besra Gurdyal S
Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae.
FEMS microbiology reviews 2004;28(2):225-50.
2004: Gibson Kevin J C; Gilleron Martine; Constant Patricia; Brando Thérèse; Puzo Germain; Besra Gurdyal S; Nigou Jérôme
Tsukamurella paurometabola lipoglycan, a new lipoarabinomannan variant with pro-inflammatory activity.
The Journal of biological chemistry 2004;279(22):22973-82.
2004: Pathak Ashish K; Pathak Vibha; Riordan James M; Gurcha Sudagar S; Besra Gurdyal S; Reynolds Robert C
Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis.
Carbohydrate research 2004;339(3):683-91.
2004: Batuwangala Thil; Shepherd Dawn; Gadola Stephan D; Gibson Kevin J C; Zaccai Nathan R; Fersht Alan R; Besra Gurdyal S; Cerundolo Vincenzo; Jones E Yvonne
The crystal structure of human CD1b with a bound bacterial glycolipid.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2382-8.
2004: Coxon Geoffrey D; Al Dulayymi Juma'a R; Morehouse Caroline; Brennan Patrick J; Besra Gurdyal S; Baird Mark S; Minnikin David E
Synthesis and properties of methyl 5-(1'R,2'S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega-19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids.
Chemistry and physics of lipids 2004;127(1):35-46.
2004: Senior Suzanne J; Illarionov Petr A; Gurcha Sudagar S; Campbell Ian B; Schaeffer Merrill L; Minnikin David E; Besra Gurdyal S
Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.
Bioorganic & medicinal chemistry letters 2004;14(2):373-6.
2004: Wilson Rosalind A; Maughan William N; Kremer Laurent; Besra Gurdyal S; Fütterer Klaus
The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases.
Journal of molecular biology 2004;335(2):519-30.
2004: Engohang-Ndong Jean; Baillat David; Aumercier Marc; Bellefontaine Flore; Besra Gurdyal S; Locht Camille; Baulard Alain R
EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator.
Molecular microbiology 2004;51(1):175-88.
2004: Im Jin S; Yu Karl O A; Illarionov Petr A; LeClair Kenneth P; Storey James R; Kennedy Malcolm W; Besra Gurdyal S; Porcelli Steven A
Direct measurement of antigen binding properties of CD1 proteins using fluorescent lipid probes.
The Journal of biological chemistry 2004;279(1):299-310.
2004: Waddell Simon J; Stabler Richard A; Laing Ken; Kremer Laurent; Reynolds Robert C; Besra Gurdyal S
The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds.
Tuberculosis (Edinburgh, Scotland) 2004;84(3-4):263-74.
2003: Molle Virginie; Kremer Laurent; Girard-Blanc Christine; Besra Gurdyal S; Cozzone Alain J; Prost Jean-François
An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
Biochemistry 2003;42(51):15300-9.
2003: Wilson Rosalind A; Rai Sonia; Maughan Willian N; Kremer Laurent; Kariuki Benson M; Harris Kenneth D M; Wagner Trixie; Besra Gurdyal S; Fütterer Klaus
Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c).
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2303-5.
2003: Phetsuksiri Benjawan; Jackson Mary; Scherman Hataichanok; McNeil Michael; Besra Gurdyal S; Baulard Alain R; Slayden Richard A; DeBarber Andrea E; Barry Clifton E; Baird Mark S; Crick Dean C; Brennan Patrick J
Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis.
The Journal of biological chemistry 2003;278(52):53123-30.
2003: Cerdeño-Tárraga A M; Efstratiou A; Dover L G; Holden M T G; Pallen M; Bentley S D; Besra G S; Churcher C; James K D; De Zoysa A; Chillingworth T; Cronin A; Dowd L; Feltwell T; Hamlin N; Holroyd S; Jagels K; Moule S; Quail M A; Rabbinowitsch E; Rutherford K M; Thomson N R; Unwin L; Whitehead S; Barrell B G; Parkhill J
The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129.
Nucleic acids research 2003;31(22):6516-23.
2003: Senior Suzanne J; Illarionov Petr A; Gurcha Sudagar S; Campbell Ian B; Schaeffer Merrill L; Minnikin David E; Besra Gurdyal S
Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.
Bioorganic & medicinal chemistry letters 2003;13(21):3685-8.
2003: Cernadas Manuela; Sugita Masahiko; van der Wel Nicole; Cao Xiaochun; Gumperz Jenny E; Maltsev Sergei; Besra Gurdyal S; Behar Samuel M; Peters Peter J; Brenner Michael B
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4149-55.
2003: Gibson Kevin J C; Eggeling Lothar; Maughan William N; Krumbach Karin; Gurcha Sudagar S; Nigou Jérôme; Puzo Germain; Sahm Hermann; Besra Gurdyal S
Disruption of Cg-Ppm1, a polyprenyl monophosphomannose synthase, and the generation of lipoglycan-less mutants in Corynebacterium glutamicum.
The Journal of biological chemistry 2003;278(42):40842-50.
2003: Gibson Kevin J C; Gilleron Martine; Constant Patricia; Puzo Germain; Nigou Jérôme; Besra Gurdyal S
Structural and functional features of Rhodococcus ruber lipoarabinomannan.
Microbiology (Reading, England) 2003;149(Pt 6):1437-45.
2003: Kremer Laurent; Dover Lynn G; Morbidoni Hector R; Vilchèze Catherine; Maughan William N; Baulard Alain; Tu Shiao-Chun; Honoré Nadine; Deretic Vojo; Sacchettini James C; Locht Camille; Jacobs William R; Besra Gurdyal S
Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.
The Journal of biological chemistry 2003;278(23):20547-54.
2003: Gibson Kevin J C; Gilleron Martine; Constant Patricia; Puzo Germain; Nigou Jérôme; Besra Gurdyal S
Identification of a novel mannose-capped lipoarabinomannan from Amycolatopsis sulphurea.
The Biochemical journal 2003;372(Pt 3):821-9.
2003: Bentley Stephen D; Maiwald Matthias; Murphy Lee D; Pallen Mark J; Yeats Corin A; Dover Lynn G; Norbertczak Halina T; Besra Gurdyal S; Quail Michael A; Harris David E; von Herbay Axel; Goble Arlette; Rutter Simon; Squares Robert; Squares Stephen; Barrell Bart G; Parkhill Julian; Relman David A
Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei.
Lancet 2003;361(9358):637-44.
2003: Waller Ross F; Ralph Stuart A; Reed Michael B; Su Vanessa; Douglas James D; Minnikin David E; Cowman Alan F; Besra Gurdyal S; McFadden Geoffrey I
A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2003;47(1):297-301.
2003: Baulard Alain R; Gurcha Sudagar S; Engohang-Ndong Jean; Gouffi Kamila; Locht Camille; Besra Gurdyal S
In vivo interaction between the polyprenol phosphate mannose synthase Ppm1 and the integral membrane protein Ppm2 from Mycobacterium smegmatis revealed by a bacterial two-hybrid system.
The Journal of biological chemistry 2003;278(4):2242-8.
2002: Larsen Michelle H; Vilchèze Catherine; Kremer Laurent; Besra Gurdyal S; Parsons Linda; Salfinger Max; Heifets Leonid; Hazbon Manzour H; Alland David; Sacchettini James C; Jacobs William R
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
Molecular microbiology 2002;46(2):453-66.
2002: Kremer Laurent; Guérardel Yann; Gurcha Sudagar S; Locht Camille; Besra Gurdyal S
Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile.
Microbiology (Reading, England) 2002;148(Pt 10):3145-54.
2002: Douglas James D; Senior Suzanne J; Morehouse Caroline; Phetsukiri Benjawan; Campbell Ian B; Besra Gurdyal S; Minnikin David E
Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity.
Microbiology (Reading, England) 2002;148(Pt 10):3101-9.
2002: Hancock Ian C; Carman Stephen; Besra Gurdyal S; Brennan Patrick J; Waite Emma
Ligation of arabinogalactan to peptidoglycan in the cell wall of Mycobacterium smegmatis requires concomitant synthesis of the two wall polymers.
Microbiology (Reading, England) 2002;148(Pt 10):3059-67.
2002: McLean Kirsty J; Marshall Ker R; Richmond Alison; Hunter Iain S; Fowler Kay; Kieser Tobias; Gurcha Sudagar S; Besra Gurydal S; Munro Andrew W
Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.
Microbiology (Reading, England) 2002;148(Pt 10):2937-49.
2002: Pathak Ashish K; Pathak Vibha; Gurcha Sudagar S; Besra Gurdyal S; Reynolds Robert C
Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 2002;12(19):2749-52.
2002: Nigou Jérôme; Besra Gurdyal S
Cytidine diphosphate-diacylglycerol synthesis in Mycobacterium smegmatis.
The Biochemical journal 2002;367(Pt 1):157-62.
2002: Kremer Laurent S; Besra Gurdyal S
Current status and future development of antitubercular chemotherapy.
Expert opinion on investigational drugs 2002;11(8):1033-49.
2002: Guerardel Yann; Maes Emmanuel; Elass Elisabeth; Leroy Yves; Timmerman Philippe; Besra Gurdyal S; Locht Camille; Strecker Gérard; Kremer Laurent
Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with alpha 1,3-mannopyranose side chains.
The Journal of biological chemistry 2002;277(34):30635-48.
2002: Cooper Howard N; Gurcha Sudagar S; Nigou Jérôme; Brennan Patrick J; Belisle John T; Besra Gurdyal S; Young Douglas
Characterization of mycobacterial protein glycosyltransferase activity using synthetic peptide acceptors in a cell-free assay.
Glycobiology 2002;12(7):427-34.
2002: Gurcha Sudagar S; Baulard Alain R; Kremer Laurent; Locht Camille; Moody D Branch; Muhlecker Walter; Costello Catherine E; Crick Dean C; Brennan Patrick J; Besra Gurdyal S
Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.
The Biochemical journal 2002;365(Pt 2):441-50.
2002: Kremer Laurent; Dover Lynn G; Carrère Séverine; Nampoothiri K Madhavan; Lesjean Sarah; Brown Alistair K; Brennan Patrick J; Minnikin David E; Locht Camille; Besra Gurdyal S
Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.
The Biochemical journal 2002;364(Pt 2):423-30.
2002: Minnikin David E; Kremer Laurent; Dover Lynn G; Besra Gurdyal S
The methyl-branched fortifications of Mycobacterium tuberculosis.
Chemistry & biology 2002;9(5):545-53.
2002: Kremer Laurent; Gurcha Sudagar S; Bifani Pablo; Hitchen Paul G; Baulard Alain; Morris Howard R; Dell Anne; Brennan Patrick J; Besra Gurdyal S
Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.
The Biochemical journal 2002;363(Pt 3):437-47.
2002: Moody D Branch; Briken Volker; Cheng Tan-Yun; Roura-Mir Carme; Guy Mark R; Geho David H; Tykocinski Mark L; Besra Gurdyal S; Porcelli Steven A
Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation.
Nature immunology 2002;3(5):435-42.
2002: Grant Ethan P; Beckman Evan M; Behar Samuel M; Degano Massimo; Frederique Daphney; Besra Gurdyal S; Wilson Ian A; Porcelli Steven A; Furlong Stephen T; Brenner Michael B
Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3933-40.
2002: Nigou Jérôme; Dover Lynn G; Besra Gurdyal S
Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis.
Biochemistry 2002;41(13):4392-8.
2002: Pathak Ashish K; Pathak Vibha; Suling William J; Gurcha Sudagar S; Morehouse Caroline B; Besra Gurdyal S; Maddry Joseph A; Reynolds Robert C
Studies on n-octyl-5-(alpha-D-arabinofuranosyl)-beta-D-galactofuranosides for mycobacterial glycosyltransferase activity.
Bioorganic & medicinal chemistry 2002;10(4):923-8.
2002: Kremer Laurent; Besra Gurdyal S
Re-emergence of tuberculosis: strategies and treatment.
Expert opinion on investigational drugs 2002;11(2):153-7.
2002: Nigou Jérôme; Besra Gurdyal S
Characterization and regulation of inositol monophosphatase activity in Mycobacterium smegmatis.
The Biochemical journal 2002;361(Pt 2):385-90.
2002: Newton Sandra M; Lau Clara; Gurcha Sudagar S; Besra Gurdyal S; Wright Colin W
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.
Journal of ethnopharmacology 2002;79(1):57-67.
2002: Kremer L; Maughan W N; Wilson R A; Dover L G; Besra G S
The M. tuberculosis antigen 85 complex and mycolyltransferase activity.
Letters in applied microbiology 2002;34(4):233-7.
2001: Pathak A K; Pathak V; Maddry J A; Suling W J; Gurcha S S; Besra G S; Reynolds R C
Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity.
Bioorganic & medicinal chemistry 2001;9(12):3145-51.
2001: Pathak A K; Pathak V; Seitz L; Maddry J A; Gurcha S S; Besra G S; Suling W J; Reynolds R C
Studies on (beta,1-->5) and (beta,1-->6) linked octyl Gal(f) disaccharides as substrates for mycobacterial galactosyltransferase activity.
Bioorganic & medicinal chemistry 2001;9(12):3129-43.
2001: Moody D B; Besra G S
Glycolipid targets of CD1-mediated T-cell responses.
Immunology 2001;104(3):243-51.
2001: Kremer L; Nampoothiri K M; Lesjean S; Dover L G; Graham S; Betts J; Brennan P J; Minnikin D E; Locht C; Besra G S
Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.
The Journal of biological chemistry 2001;276(30):27967-74.
2001: Kremer L; Dover L G; Morehouse C; Hitchin P; Everett M; Morris H R; Dell A; Brennan P J; McNeil M R; Flaherty C; Duncan K; Besra G S
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase.
The Journal of biological chemistry 2001;276(28):26430-40.
2001: Brown J R; Field R A; Barker A; Guy M; Grewal R; Khoo K H; Brennan P J; Besra G S; Chatterjec D
Synthetic mannosides act as acceptors for mycobacterial alpha1-6 mannosyltransferase.
Bioorganic & medicinal chemistry 2001;9(4):815-24.
2000: Moody D B; Guy M R; Grant E; Cheng T Y; Brenner M B; Besra G S; Porcelli S A
CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection.
The Journal of experimental medicine 2000;192(7):965-76.
2000: Crick D C; Schulbach M C; Zink E E; Macchia M; Barontini S; Besra G S; Brennan P J
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.
Journal of bacteriology 2000;182(20):5771-8.
2000: Mikusová K; Yagi T; Stern R; McNeil M R; Besra G S; Crick D C; Brennan P J
Biosynthesis of the galactan component of the mycobacterial cell wall.
The Journal of biological chemistry 2000;275(43):33890-7.
2000: Baulard A R; Betts J C; Engohang-Ndong J; Quan S; McAdam R A; Brennan P J; Locht C; Besra G S
Activation of the pro-drug ethionamide is regulated in mycobacteria.
The Journal of biological chemistry 2000;275(36):28326-31.
2000: Kremer L; Douglas J D; Baulard A R; Morehouse C; Guy M R; Alland D; Dover L G; Lakey J H; Jacobs W R; Brennan P J; Minnikin D E; Besra G S
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.
The Journal of biological chemistry 2000;275(22):16857-64.
2000: Moody D B; Ulrichs T; Mühlecker W; Young D C; Gurcha S S; Grant E; Rosat J P; Brenner M B; Costello C E; Besra G S; Porcelli S A
CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection.
Nature 2000;404(6780):884-8.
2000: Ronning D R; Klabunde T; Besra G S; Vissa V D; Belisle J T; Sacchettini J C
Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.
Nature structural biology 2000;7(2):141-6.
1999: Moody D B; Besra G S; Wilson I A; Porcelli S A
The molecular basis of CD1-mediated presentation of lipid antigens.
Immunological reviews 1999;172():285-96.
1999: Pathak A K; Besra G S; Crick D; Maddry J A; Morehouse C B; Suling W J; Reynolds R C
Studies on beta-D-Gal(f)-(1-->4)-alpha-L-Rha(p) octyl analogues as substrates for mycobacterial galactosyl transferase activity.
Bioorganic & medicinal chemistry 1999;7(11):2407-13.
1999: Schaeffer M L; Khoo K H; Besra G S; Chatterjee D; Brennan P J; Belisle J T; Inamine J M
The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis.
The Journal of biological chemistry 1999;274(44):31625-31.
1999: Phetsuksiri B; Baulard A R; Cooper A M; Minnikin D E; Douglas J D; Besra G S; Brennan P J
Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis.
Antimicrobial agents and chemotherapy 1999;43(5):1042-51.
1999: Moody D B; Reinhold B B; Reinhold V N; Besra G S; Porcelli S A
Uptake and processing of glycosylated mycolates for presentation to CD1b-restricted T cells.
Immunology letters 1999;65(1-2):85-91.
1998: Waller R F; Keeling P J; Donald R G; Striepen B; Handman E; Lang-Unnasch N; Cowman A F; Besra G S; Roos D S; McFadden G I
Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12352-7.
1998: Lee R E; Brennan P J; Besra G S
Synthesis of beta-D-arabinofuranosyl-1-monophosphoryl polyprenols: examination of their function as mycobacterial arabinosyl transferase donors.
Bioorganic & medicinal chemistry letters 1998;8(8):951-4.
1998: Ayers J D; Lowary T L; Morehouse C B; Besra G S
Synthetic arabinofuranosyl oligosaccharides as mycobacterial arabinosyltransferase substrates.
Bioorganic & medicinal chemistry letters 1998;8(5):437-42.
1998: Besra G S
Preparation of cell-wall fractions from mycobacteria.
Methods in molecular biology (Clifton, N.J.) 1998;101():91-107.
1997: Lee R E; Brennan P J; Besra G S
Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assay.
Glycobiology 1997;7(8):1121-8.
1997: Moody D B; Reinhold B B; Guy M R; Beckman E M; Frederique D E; Furlong S T; Ye S; Reinhold V N; Sieling P A; Modlin R L; Besra G S; Porcelli S A
Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells.
Science (New York, N.Y.) 1997;278(5336):283-6.
1997: Besra G S; Brennan P J
The mycobacterial cell wall: biosynthesis of arabinogalactan and lipoarabinomannan.
Biochemical Society transactions 1997;25(3):845-50.
1997: Besra G S; Morehouse C B; Rittner C M; Waechter C J; Brennan P J
Biosynthesis of mycobacterial lipoarabinomannan.
The Journal of biological chemistry 1997;272(29):18460-6.
1997: Lee R E; Armour J W; Takayama K; Brennan P J; Besra G S
Mycolic acid biosynthesis: definition and targeting of the Claisen condensation step.
Biochimica et biophysica acta 1997;1346(3):275-84.
1997: Xin Y; Lee R E; Scherman M S; Khoo K H; Besra G S; Brennan P J; McNeil M
Characterization of the in vitro synthesized arabinan of mycobacterial cell walls.
Biochimica et biophysica acta 1997;1335(3):231-4.
1997: Belisle J T; Vissa V D; Sievert T; Takayama K; Brennan P J; Besra G S
Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis.
Science (New York, N.Y.) 1997;276(5317):1420-2.
1997: Brennan P J; Besra G S
Structure, function and biogenesis of the mycobacterial cell wall.
Biochemical Society transactions 1997;25(1):188-94.
1997: Weston A; Stern R J; Lee R E; Nassau P M; Monsey D; Martin S L; Scherman M S; Besra G S; Duncan K; McNeil M R
Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1997;78(2):123-31.
1996: Slayden R A; Lee R E; Armour J W; Cooper A M; Orme I M; Brennan P J; Besra G S
Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis.
Antimicrobial agents and chemotherapy 1996;40(12):2813-9.
1996: Liu J; Barry C E; Besra G S; Nikaido H
Mycolic acid structure determines the fluidity of the mycobacterial cell wall.
The Journal of biological chemistry 1996;271(47):29545-51.
1996: Khoo K H; Douglas E; Azadi P; Inamine J M; Besra G S; Mikusová K; Brennan P J; Chatterjee D
Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutol.
The Journal of biological chemistry 1996;271(45):28682-90.
1996: Belanger A E; Besra G S; Ford M E; Mikusová K; Belisle J T; Brennan P J; Inamine J M
The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11919-24.
1996: Khoo K H; Suzuki R; Dell A; Morris H R; McNeil M R; Brennan P J; Besra G S
Chemistry of the lyxose-containing mycobacteriophage receptors of Mycobacterium phlei/Mycobacterium smegmatis.
Biochemistry 1996;35(36):11812-9.
1996: Mikusová K; Mikus M; Besra G S; Hancock I; Brennan P J
Biosynthesis of the linkage region of the mycobacterial cell wall.
The Journal of biological chemistry 1996;271(13):7820-8.
1996: Lee R E; Brennan P J; Besra G S
Mycobacterium tuberculosis cell envelope.
Current topics in microbiology and immunology 1996;215():1-27.
1995: Mikusová K; Slayden R A; Besra G S; Brennan P J
Biogenesis of the mycobacterial cell wall and the site of action of ethambutol.
Antimicrobial agents and chemotherapy 1995;39(11):2484-9.
1995: Khoo K H; Suzuki R; Morris H R; Dell A; Brennan P J; Besra G S
Structural definition of the glycopeptidolipids and the pyruvylated, glycosylated acyltrehalose from Mycobacterium butyricum.
Carbohydrate research 1995;276(2):449-55.
1995: Yuan Y; Lee R E; Besra G S; Belisle J T; Barry C E
Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6630-4.
1995: Besra G S; Khoo K H; McNeil M R; Dell A; Morris H R; Brennan P J
A new interpretation of the structure of the mycolyl-arabinogalactan complex of Mycobacterium tuberculosis as revealed through characterization of oligoglycosylalditol fragments by fast-atom bombardment mass spectrometry and 1H nuclear magnetic resonance spectroscopy.
Biochemistry 1995;34(13):4257-66.
1994: Besra G S; Sievert T; Lee R E; Slayden R A; Brennan P J; Takayama K
Identification of the apparent carrier in mycolic acid synthesis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12735-9.
1994: Hartmann S; Besra G S; Fraser J L; König W A; Minnikin D E; Ridell M
Stereochemistry of 2,4-dimethyleicos-2-enoate from the pyruvylated glycolipid of Mycobacterium smegmatis.
Biochimica et biophysica acta 1994;1201(3):339-44.
1994: Besra G S; Gurcha S S; Khoo K H; Morris H R; Dell A; Hamid M E; Minnikin D E; Goodfellow M; Brennan P J
Characterization of the specific antigenicity of representatives of M. senegalense and related bacteria.
Zentralblatt für Bakteriologie : international journal of medical microbiology 1994;281(4):415-32.
1994: Besra G S; Khoo K H; Belisle J T; McNeil M R; Morris H R; Dell A; Brennan P J
New pyruvylated, glycosylated acyltrehaloses from Mycobacterium smegmatis strains, and their implications for phage resistance in mycobacteria.
Carbohydrate research 1994;251():99-114.
1993: Besra G S; McNeil M R; Khoo K H; Dell A; Morris H R; Brennan P J
Trehalose-containing lipooligosaccharides of Mycobacterium gordonae: presence of a mono-O-methyltetra-O-acyltrehalose "core" and branching in the oligosaccharide backbone.
Biochemistry 1993;32(47):12705-14.
1993: Besra G S; Minnikin D E; Wheeler P R; Ratledge C
Synthesis of methyl (Z)-tetracos-5-enoate and both enantiomers of ethyl (E)-6-methyltetracos-4-enoate: possible intermediates in the biosynthesis of mycolic acids in mycobacteria.
Chemistry and physics of lipids 1993;66(1-2):23-34.
1993: Wheeler P R; Besra G S; Minnikin D E; Ratledge C
Stimulation of mycolic acid biosynthesis by incorporation of cis-tetracos-5-enoic acid in a cell-wall preparation from Mycobacterium smegmatis.
Biochimica et biophysica acta 1993;1167(2):182-8.
1993: Besra G S; McNeil M R; Rivoire B; Khoo K H; Morris H R; Dell A; Brennan P J
Further structural definition of a new family of glycopeptidolipids from Mycobacterium xenopi.
Biochemistry 1993;32(1):347-55.
1993: Minnikin D E; Besra G S; Bolton R C; Datta A K; Mallet A I; Sharif A; Stanford J L; Ridell M; Magnusson M
Identification of the leprosy bacillus and related mycobacteria by analysis of mycocerosate profiles.
Annales de la Société belge de médecine tropicale 1993;73 Suppl 1():25-34.
1993: Minnikin D E; Bolton R C; Hartmann S; Besra G S; Jenkins P A; Mallet A I; Wilkins E; Lawson A M; Ridell M
An integrated procedure for the direct detection of characteristic lipids in tuberculosis patients.
Annales de la Société belge de médecine tropicale 1993;73 Suppl 1():13-24.
1992: Besra G S; Bolton R C; McNeil M R; Ridell M; Simpson K E; Glushka J; van Halbeek H; Brennan P J; Minnikin D E
Structural elucidation of a novel family of acyltrehaloses from Mycobacterium tuberculosis.
Biochemistry 1992;31(40):9832-7.
1992: Besra G S; McNeil M R; Brennan P J
Characterization of the specific antigenicity of Mycobacterium fortuitum.
Biochemistry 1992;31(28):6504-9.
1991: Besra G S; McNeil M; Minnikin D E; Portaels F; Ridell M; Brennan P J
Structural elucidation and antigenicity of a novel phenolic glycolipid antigen from Mycobacterium haemophilum.
Biochemistry 1991;30(31):7772-7.
1990: Dobson G; Minnikin D E; Besra G S; Mallet A I; Magnusson M
Characterisation of phenolic glycolipids from Mycobacterium marinum.
Biochimica et biophysica acta 1990;1042(2):176-81.
1990: Besra G S; Minnikin D E; Sharif A; Stanford J L
Characteristic new members of the phthiocerol and phenolphthiocerol families from Mycobacterium ulcerans.
FEMS microbiology letters 1990;54(1-3):11-4.
1989: Besra G S; Minnikin D E; Bolton R C; Datta A K; Mallet A I; Jenkins P A
Detection of mycobacteria in infected tissue.
Acta leprologica 1989;7 Suppl 1():59-60.
1989: Minnikin D E; Ridell M; Wallerström G; Besra G S; Parlett J H; Bolton R C; Magnusson M
Comparative studies of antigenic glycolipids of mycobacteria related to the leprosy bacillus.
Acta leprologica 1989;7 Suppl 1():51-4.

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