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Gurdyal Besra

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Peter J Jervis; John-Paul Jukes; Paolo Polzella; Justyna Wojno; Gurdyal S Besra; Vincenzo Cerundolo; Yoel R Garcia Diaz; Hemza Ghadbane; Liam R Cox
Design, synthesis, and functional activity of labeled CD1d glycolipid agonists.
Anaximandro Gómez-Velasco; Amrita K Rana; Horacio Bach; Gurdyal S Besra; Apoorva Bhatt; Liam R Cox; Yossef Av-Gay
Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis.
Crina Paduraru; James A Shayman; Natacha Veerapen; Robert Kelly; Amit Kunte; Gurdyal S Besra; Jelena S Bezbradica; Liam R Cox; Peter Cresswell
Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.

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2013: Peter J Jervis; John-Paul Jukes; Paolo Polzella; Justyna Wojno; Gurdyal S Besra; Vincenzo Cerundolo; Yoel R Garcia Diaz; Hemza Ghadbane; Liam R Cox
Design, synthesis, and functional activity of labeled CD1d glycolipid agonists.
Bioconjugate chemistry 2013;24(4):586-94.
2013: Anaximandro Gómez-Velasco; Amrita K Rana; Horacio Bach; Gurdyal S Besra; Apoorva Bhatt; Liam R Cox; Yossef Av-Gay
Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis.
Microbiology (Reading, England) 2013;159(Pt 4):726-36.
2013: Crina Paduraru; James A Shayman; Natacha Veerapen; Robert Kelly; Amit Kunte; Gurdyal S Besra; Jelena S Bezbradica; Liam R Cox; Peter Cresswell
Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(13):5097-102.
2013: Thi Kim Anh Nguyen; Wiebren J Santema; Serge van Calenbergh; Gurdyal S Besra; Liam R Cox; Simon P Graham; Peter J Jervis; Ad P Koets; D Branch Moody; Martin Vordermeier; Dirk Zajonc; Ildiko Van Rhijn
The bovine CD1D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C26 fatty acid.
International immunology 2013;25(2):91-8.
2013: Raju V V Tatituri; Gerald F M Watts; Catarina F Almeida; Nathaniel Barton; Samuel M Behar; Gurdyal S Besra; Veemal Bhowruth; Michael B Brenner; Susanna Cardell; Liam R Cox; Lothar Eggeling; Dale I Godfrey; Fong-Fu Hsu; Jamie Rossjohn; Alissa Rothchild; Manfred Brigl
Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1827-32.
2013: Dhinakaran Sambandan; Catherine Vilchèze; Brian Charles Weinrick; Laurent Kremer; Anil Ojha; Gurdyal S Besra; Dee N Dao; Sudagar S Gurcha; Graham F Hatfull; William R Jacobs
Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis.
mBio 2013;4(3):.
2013: G Michael Taylor; Katie Tucker; Houdini H T Wu; Gurdyal S Besra; Rachel Butler; Stewart T Cole; Oona Y-C Lee; Jamie Lewis; Philip Marter; David E Minnikin; Alistair W G Pike; Simon Roffey; Pushpendra Singh; Graham R Stewart
Detection and Strain Typing of Ancient Mycobacterium leprae from a Medieval Leprosy Hospital.
PloS one 2013;8(4):e62406.
2013: Modesto J Remuiñán; Joaquín Rullás; Verónica Sousa; Vickey L Spivey; Johnson Afari; Carlos Alemparte; Iñigo Angulo-Barturen; Lluis Ballell; David Barros; Gurdyal S Besra; Mónica Cacho; Chrystala Constantinidou; David J Dow; Jorge Esquivias; María Teresa Fraile-Gabaldón; Carolina González; Elena Jiménez; Nicholas J Loman; María Martínez-Hoyos; Nalini Mehta; Alfonso Mendoza-Losana; Douglas J Minick; Fátima Ortega-Muro; Mark J Pallen; Esther Pérez-Herrán; María José Rebollo-López; Nicholas Cammack
Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6',7'-Dihydrospiro[Piperidine-4,4'-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3.
PloS one 2013;8(4):e60933.
2012: Arun K Mishra; Jerome Nigou; Margarida Saraiva; Joana E Alves; António G Castro; Lothar Eggeling; Jeroen Geurtsen; Karin Krumbach; Gurdyal S Besra
Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell differentiation.
The Journal of biological chemistry 2012;287(53):44173-83.
2012: Kwok S Wun; Gurdyal S Besra; Dale I Godfrey; Amy R Howell; Santosh Keshipeddy; Onisha Patel; Steven A Porcelli; Stewart K Richardson; Fiona Ross; Jamie Rossjohn
Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex.
The Journal of biological chemistry 2012;287(46):39139-48.
2012: Peter J Jervis; John-Paul Jukes; Marie Moulis; Vincenzo Cerundolo; Liam R Cox; Hemza Ghadbane; Gurdyal S Besra
Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues.
Carbohydrate research 2012;356():152-62.
2012: Sarah M Batt; Luke Alderwick; Veemal Bhowruth; Lothar Eggeling; Klaus Fütterer; Talat Jabeen; Peter A Lund; Lee Quill; Gurdyal S Besra
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(28):11354-9.
2012: Cynthia Detre; Natividad Garrido-Mesa; Marton Keszei; Katalin Kis-Toth; Elizabeth A Leadbetter; Amma F Agyemang; Gurdyal S Besra; Michael C Carroll; Wilson Castro; George C Tsokos; Natacha Veerapen; Ninghai Wang; Cox Terhorst
SAP expression in invariant NKT cells is required for cognate help to support B-cell responses.
Blood 2012;120(1):122-9.
2012: Peter J Jervis; Steven A Porcelli; Liam R Cox; Erin L Foster; Lisa M Graham; Gurdyal S Besra
New CD1d agonists: synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides.
Bioorganic & medicinal chemistry letters 2012;22(13):4348-52.
2012: Anneliese O Speak; Daniëlle te Vruchte; Natacha Veerapen; James E Wraith; Nicole M Yanjanin; Nick Platt; Forbes D Porter; Heiko Runz; Mariolina Salio; Dawn Shepherd; Louise Simmons; David A Smith; Michael Beck; Gurdyal S Besra; Vincenzo Cerundolo; Ralf Hartung; Christian J Hendriksz; Jackie Imrie; Robin H Lachmann; Eugen Mengel; Frances M Platt
Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C.
European journal of immunology 2012;42(7):1886-92.
2012: Arun K Mishra; Doris Rittmann; Julia Frunzke; Karin Krumbach; Oona Y-C Lee; Sarah M Batt; Gurdyal S Besra; Sandip De; Lothar Eggeling
Deletion of manC in Corynebacterium glutamicum results in a phospho-myo-inositol mannoside- and lipoglycan-deficient mutant.
Microbiology (Reading, England) 2012;158(Pt 7):1908-17.
2012: Aniek D van der Woude; Gurdyal S Besra; Apoorva Bhatt; Louis Boon; Jeroen Geurtsen; Edith N G Houben; Joen Luirink; Susanne A Raadsen; Debasmita Sarkar; Marion Sparrius; Astrid van der Sar; Wilbert Bitter
Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum.
The Journal of biological chemistry 2012;287(24):20417-29.
2012: Justyna Wojno; Gurdyal S Besra; Vincenzo Cerundolo; Hemza Ghadbane; John-Paul Jukes; Dawn Shepherd; Liam R Cox
Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production.
ACS chemical biology 2012;7(5):847-55.
2012: Lan Wu; David H Wasserman; Brandon Williams; Gurdyal S Besra; Deanna P Bracy; Curtis L Gabriel; Sungjune Kim; Jefferson P Lomenick; Pamela A Marks-Shulman; Yanice V Mendez-Fernandez; Vrajesh V Parekh; Robyn A Tamboli; Luc Van Kaer
Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):E1143-52.
2012: Veeraraghavan Usha; Adrian Lloyd; Andrew L Lovering; Gurdyal S Besra
Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes.
FEMS microbiology letters 2012;330(1):10-6.
2012: Cristian Varela; Gurdyal S Besra; Kiranmai Bhatt; Lothar Eggeling; Karin Krumbach; Doris Rittmann; Albel Singh; Apoorva Bhatt
MmpL genes are associated with mycolic acid metabolism in mycobacteria and corynebacteria.
Chemistry & biology 2012;19(4):498-506.
2012: Luis León; Adriaan J Minnaard; D Branch Moody; Wei Peng; Ying Sun; Raju V V Tatituri; Natacha Veerapen; Duarte C Barral; Gurdyal S Besra; Veemal Bhowruth; Gregory A Grabowski; Rosa Grenha; Anne Kasmar; Michael B Brenner
Saposins utilize two strategies for lipid transfer and CD1 antigen presentation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(12):4357-64.
2012: Katherine A Abrahams; Carlos Alemparte; Lluis Ballell; David Barros; Chrystala Constantinidou; Jonathan A G Cox; Raquel Fernández; Nicholas J Loman; Mark J Pallen; Modesto J Remuiñán; Vickey L Spivey; Gurdyal S Besra
Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB.
PloS one 2012;7(12):e52951.
2012: Amrita K Rana; Albel Singh; Apoorva Bhatt; Liam R Cox; Sudagar S Gurcha; Gurdyal S Besra
Ppm1-encoded polyprenyl monophosphomannose synthase activity is essential for lipoglycan synthesis and survival in mycobacteria.
PloS one 2012;7(10):e48211.
2012: Oona Y-C Lee; Larry D Martin; David E Minnikin; Bruce M Rothschild; Mark Spigelman; Houdini H T Wu; Ian D Bull; Helen D Donoghue; Charles L Greenblatt; Gurdyal S Besra
Mycobacterium tuberculosis complex lipid virulence factors preserved in the 17,000-year-old skeleton of an extinct bison, Bison antiquus.
PloS one 2012;7(7):e41923.
2012: Chris Pirson; Sabine Steinbach; Gurdyal S Besra; Gareth J Jones; H Martin Vordermeier
Differential effects of Mycobacterium bovis - derived polar and apolar lipid fractions on bovine innate immune cells.
Veterinary research 2012;43(1):54.
2012: Veeraraghavan Usha; Sudagar S Gurcha; Judith V Hobrath; Robert C Reynolds; Gurdyal S Besra
Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis.
PloS one 2012;7(3):e33886.
2011: Patrick J Brennan; Gurdyal S Besra; Manfred Brigl; Stephan D Gadola; Fong-Fu Hsu; Edy Y Kim; Joseph Sanderson; Raju V V Tatituri; Amit Tuli; Michael B Brenner
Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals.
Nature immunology 2011;12(12):1202-11.
2011: Onisha Patel; Daniel G Pellicci; Steven A Porcelli; Stewart K Richardson; Jamie Rossjohn; Lucy C Sullivan; Adam P Uldrich; Jingjing Zhang; Romain Bedel; Gurdyal S Besra; Mugdha Bhati; Andrew G Brooks; Laurent Gapin; Amy R Howell; Lars Kjer-Nielsen; Thierry Mallevaey; James McCluskey; Melissa McKnight; Dale I Godfrey
Vβ2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(47):19007-12.
2011: Nadia R Cohen; Beth B Fuchs; Edy Y Kim; Stuart M Levitz; Eleftherios Mylonakis; Amariliz Rivera; Raju V V Tatituri; Gerald F M Watts; Gurdyal S Besra; Manfred Brigl; Asako Chiba; Michael B Brenner
Innate recognition of cell wall β-glucans drives invariant natural killer T cell responses against fungi.
Cell host & microbe 2011;10(5):437-50.
2011: Arun K Mishra; Nicole N Driessen; Ben J Appelmelk; Gurdyal S Besra
Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host-pathogen interaction.
FEMS microbiology reviews 2011;35(6):1126-57.
2011: Yuki Kinjo; Peter W Andrew; Gurdyal S Besra; Samira Dahesh; Enrico Girardi; Anaximandro Gómez-Velasco; Petr Illarionov; Masakazu Imamura; Yukihiro Kaneko; Kazuyoshi Kawahara; Kazuyoshi Kawakami; Archana Khurana; Xiangming Li; Yali Li; Yoshitsugu Miyazaki; Victor Nizet; Akiko Okawara; Bo Pei; Paul Rogers; Moriya Tsuji; Satoshi Uchiyama; José Luis Vela; Chi-Huey Wong; Hasan Yesilkaya; Dirk Zajonc; Mitchell Kronenberg
Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria.
Nature immunology 2011;12(10):966-74.
2011: Fenna C M Sillé; Samuel M Behar; Gurdyal S Besra; Pushpa Jayaraman; Constance Martin; Alissa Rothchild; Marianne Boes
Critical role for invariant chain in CD1d-mediated selection and maturation of Vα14-invariant NKT cells.
Immunology letters 2011;139(1-2):33-41.
2011: Jagan R Muppidi; Masato Tanaka; Natacha Veerapen; Tal I Arnon; Gurdyal S Besra; Yelena Bronevetsky; Jason G Cyster
Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone.
The Journal of experimental medicine 2011;208(10):1941-8.
2011: Daniel G Pellicci; Steven A Porcelli; Adam P Uldrich; Travis Beddoe; Gurdyal S Besra; Andrew J Clarke; Laurent Gapin; Dale I Godfrey; Jérôme Le Nours; Thierry Mallevaey; James McCluskey; Onisha Patel; Jamie Rossjohn
Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors.
Nature immunology 2011;12(9):827-33.
2011: Salil Garg; Nir Hacohen; David L Hava; Mahak Sharma; Amit Tuli; Cindy Ung; Natacha Veerapen; Duarte C Barral; Gurdyal S Besra; Michael B Brenner
Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.
Immunity 2011;35(2):182-93.
2011: Fenna C M Sillé; Samuel M Behar; Gurdyal S Besra; Sarah Fortune; Pushpa Jayaraman; Constance Martin; Alissa Rothchild; Marianne Boes
Requirement for invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation.
Infection and immunity 2011;79(8):3053-63.
2011: Kuppan Gokulan; Anup Aggarwal; Gurdyal S Besra; Lance Shipman; James C Sacchettini
Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations.
Acta crystallographica. Section D, Biological crystallography 2011;67(Pt 7):657-69.
2011: Adam P Uldrich; Julian P Vivian; Spencer J Williams; Gurdyal S Besra; Andrew G Brooks; Garth Cameron; Benjamin Cao; E Bridie Day; Petr A Illarionov; Lars Kjer-Nielsen; Konstantinos Kyparissoudis; James McCluskey; Onisha Patel; Daniel G Pellicci; Steven A Porcelli; Jamie Rossjohn; Mark J Smyth; Lucy C Sullivan; Stephen J Turner; Dale I Godfrey
A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties.
Nature immunology 2011;12(7):616-23.
2011: Esther J M Stoop; Christina M.J.E, Vandenbroucke-Grauls; Fons J Verbeek; Sietske K Rosendahl Huber; Gurdyal S Besra; Wilbert Bitter; Sudagar S Gurcha; Alexander E Nezhinsky; Tim Schipper; Astrid van der Sar
Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component.
Disease models & mechanisms 2011;4(4):526-36.
2011: Randip Kaur; Jili Chen; Amina Dawoodji; Vincenzo Cerundolo; Yoel R Garcia-Diaz; Justyna Wojno; Liam R Cox; Gurdyal S Besra; Behfar Moghaddam; Yvonne Perrie
Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells.
Journal of pharmaceutical sciences 2011;100(7):2724-33.
2011: Manfred Brigl; Nadia R Cohen; Fong-Fu Hsu; Elizabeth A Leadbetter; Raju V V Tatituri; Gerald F M Watts; Nathaniel Barton; Gurdyal S Besra; Veemal Bhowruth; Michael B Brenner
Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.
The Journal of experimental medicine 2011;208(6):1163-77.
2011: Damien J Montamat-Sicotte; Kerry A Millington; Carrie R Willcox; Suzie Hingley-Wilson; Sarah Hackforth; John Innes; Onn Min Kon; David A Lammas; David E Minnikin; Gurdyal S Besra; Benjamin E Willcox; Ajit Lalvani
A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection.
The Journal of clinical investigation 2011;121(6):2493-503.
2011: Debasmita Sarkar; Mandeep Sidhu; Albel Singh; Jiemin Chen; David A Lammas; Astrid M van der Sar; Gurdyal S Besra; Apoorva Bhatt
Identification of a glycosyltransferase from Mycobacterium marinum involved in addition of a caryophyllose moiety in lipooligosaccharides.
Journal of bacteriology 2011;193(9):2336-40.
2011: Pooja Arora; Venkataswamy Manjunatha; Andres Baena; Gabriel Bricard; Qian Li; Natacha Veerapen; Rachel M Ndonye; Jeong Ju Park; Ji Hyung Lee; Kyung-Chang Seo; Amy R Howell; Young-Tae Chang; Petr A Illarionov; Gurdyal S Besra; Sung-Kee Chung; Steven A Porcelli
A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids.
Journal of the American Chemical Society 2011;133(14):5198-201.
2011: Rafael Prados-Rosales; Andres Baena; Luis R Martinez; Jose Luque-Garcia; Rainer Kalscheuer; Usha Veeraraghavan; Carmen Camara; Joshua D Nosanchuk; Gurdyal S Besra; Bing Chen; Juan Jimenez; Aharona Glatman-Freedman; William R. Jacobs Jr.; Steven A Porcelli; Arturo Casadevall
Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.
The Journal of clinical investigation 2011;121(4):1471-83.
2011: Luke Alderwick; Georgina S Lloyd; Adrian J Lloyd; Andrew L Lovering; Lothar Eggeling; Gurdyal S Besra
Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase.
Glycobiology 2011;21(4):410-25.
2011: Kwok S Wun; Garth Cameron; Onisha Patel; Siew Siew Pang; Daniel G Pellicci; Lucy C Sullivan; Santosh Keshipeddy; Mary H Young; Adam P Uldrich; Meena S Thakur; Stewart K Richardson; Amy R Howell; Petr A Illarionov; Andrew G Brooks; Gurdyal S Besra; James McCluskey; Laurent Gapin; Steven A Porcelli; Dale I Godfrey; Jamie Rossjohn
A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells.
Immunity 2011;34(3):327-39.
2011: Luke Alderwick; Georgina S Lloyd; Hemza Ghadbane; John W May; Apoorva Bhatt; Lothar Eggeling; Klaus Fütterer; Gurdyal S Besra
The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module.
PLoS pathogens 2011;7(2):e1001299.
2011: Jessica J O'Konek; Petr Illarionov; Deborah Stewart Khursigara; Elena Ambrosino; Liat Izhak; Bernard F Castillo; Ravinder Raju; Maryam Khalili; Hee-Yong Kim; Amy R Howell; Gurdyal S Besra; Steven A Porcelli; Jay A Berzofsky; Masaki Terabe
Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity.
The Journal of clinical investigation 2011;121(2):683-94.
2011: Peter J Jervis; Liam R Cox; Gurdyal S Besra
Synthesis of a versatile building block for the preparation of 6-N-derivatized α-galactosyl ceramides: rapid access to biologically active glycolipids.
The Journal of organic chemistry 2011;76(1):320-3.
2011: Ya-Jen Chang; Hye Young Kim; Lee A Albacker; Hyun Hee Lee; Nicole Baumgarth; Shizuo Akira; Paul B Savage; Shin Endo; Takashi Yamamura; Janneke Maaskant; Naoki Kitano; Abel Singh; Apoorva Bhatt; Gurdyal S Besra; Peter van den Elzen; Ben Appelmelk; Richard W Franck; Guangwu Chen; Rosemarie H Dekruyff; Michio Shimamura; Petr Illarionov; Dale T Umetsu
Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity.
The Journal of clinical investigation 2011;121(1):57-69.
2011: Natacha Veerapen; Faye Reddington; Mariolina Salio; Vincenzo Cerundolo; Gurdyal S Besra
Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation.
Bioorganic & medicinal chemistry 2011;19(1):221-8.
2011: Veeraraghavan Usha; Sudagar S Gurcha; Andrew L Lovering; Adrian Lloyd; Athina Papaemmanouil; Robert C Reynolds; Gurdyal S Besra
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis.
Microbiology (Reading, England) 2011;157(Pt 1):290-9.
2010: Rainer Kalscheuer; Brian Charles Weinrick; Usha Veeraraghavan; Gurdyal S Besra; William R. Jacobs Jr.
Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21761-6.
2010: Sarah M Batt; Talat Jabeen; Arun K Mishra; Natacha Veerapen; Karin Krumbach; Lothar Eggeling; Gurdyal S Besra; Klaus Fütterer
Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.
The Journal of biological chemistry 2010;285(48):37741-52.
2010: Nicole N Driessen; Esther J M Stoop; Roy Ummels; Sudagar S Gurcha; Arun K Mishra; Gérald Larrouy-Maumus; Jerome Nigou; Martine GILLERON; Germain Puzo; JJ Maaskant; Marion Sparrius; Gurdyal S Besra; Wilbert Bitter; Christina M.J.E, Vandenbroucke-Grauls; Ben J Appelmelk
Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan.
Microbiology (Reading, England) 2010;156(Pt 11):3492-502.
2010: Mauro Lo Conte; Alberto Marra; Angela Chambery; Sudagar S Gurcha; Gurdyal S Besra; Alessandro Dondoni
Modular approach to triazole-linked 1,6-α-D-oligomannosides to the discovery of inhibitors of Mycobacterium tuberculosis cell wall synthetase.
The Journal of organic chemistry 2010;75(19):6326-36.
2010: Isabel Sada-Ovalle; Markus Sköld; Tian Tian; Gurdyal S Besra; Samuel M Behar
Alpha-galactosylceramide as a therapeutic agent for pulmonary Mycobacterium tuberculosis infection.
American journal of respiratory and critical care medicine 2010;182(6):841-7.
2010: Sebastian Zeissig; Stephanie K Dougan; Duarte C Barral; Yvonne Junker; Zhangguo Chen; Arthur Kaser; Madelyn Ho; Hannah Mandel; Adam McIntyre; Susan M Kennedy; Gavin F Painter; Natacha Veerapen; Gurdyal S Besra; Vincenzo Cerundolo; Simon Yue; Sarah Beladi; Samuel M Behar; Xiuxu Chen; Jenny E Gumperz; Karine Breckpot; Anna Raper; Amanda Baer; Mark A Exley; Robert A Hegele; Marina Cuchel; Daniel J Rader; Nicholas O Davidson; Richard S Blumberg
Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.
The Journal of clinical investigation 2010;120(8):2889-99.
2010: Enrico Girardi; Jing Wang; Thien-Thi Mac; Cees Versluis; Veemal Bhowruth; Gurdyal S Besra; Albert J R Heck; Ildiko Van Rhijn; Dirk Zajonc
Crystal structure of bovine CD1b3 with endogenously bound ligands.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):376-86.
2010: Rebecca C Taylor; Alistair K Brown; Albel Singh; Apoorva Bhatt; Gurdyal S Besra
Characterization of a beta-hydroxybutyryl-CoA dehydrogenase from Mycobacterium tuberculosis.
Microbiology (Reading, England) 2010;156(Pt 7):1975-82.
2010: Peter J Jervis; Natacha Veerapen; Gabriel Bricard; Liam R Cox; Steven A Porcelli; Gurdyal S Besra
Synthesis and biological activity of alpha-glucosyl C24:0 and C20:2 ceramides.
Bioorganic & medicinal chemistry letters 2010;20(12):3475-8.
2010: Natacha Veerapen; Faye Reddington; Gabriel Bricard; Steven A Porcelli; Gurdyal S Besra
Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000.
Bioorganic & medicinal chemistry letters 2010;20(11):3223-6.
2010: Artur N Odyniec; Duarte C Barral; Salil Garg; Raju V Tatituri; Gurdyal S Besra; Michael B Brenner
Regulation of CD1 antigen-presenting complex stability.
The Journal of biological chemistry 2010;285(16):11937-47.
2010: Patricia Barral; Paolo Polzella; Andreas Bruckbauer; Nico van Rooijen; Gurdyal S Besra; Vincenzo Cerundolo; Facundo D Batista
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.
Nature immunology 2010;11(4):303-12.
2010: Amy E Trunkfield; Sudagar S Gurcha; Gurdyal S Besra; Timothy D H Bugg
Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics.
Bioorganic & medicinal chemistry 2010;18(7):2651-63.
2010: Karen Muindi; Manuela Cernadas; Gerald F M Watts; Louise Royle; David C A Neville; Raymond A Dwek; Gurdyal S Besra; Pauline M Rudd; Terry D Butters; Michael B Brenner
Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d [corrected].
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3052-7.
2010: Helen L Birch; Luke Alderwick; Ben J Appelmelk; Janneke Maaskant; Apoorva Bhatt; Albel Singh; Jerome Nigou; Lothar Eggeling; Jeroen Geurtsen; Gurdyal S Besra
A truncated lipoglycan from mycobacteria with altered immunological properties.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2634-9.
2010: Helen D Donoghue; Oona Ying-Chi Lee; David E Minnikin; Gurdyal S Besra; John H Taylor; Mark Spigelman
Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis.
Proceedings. Biological sciences / The Royal Society 2010;277(1678):51-6.
2010: Isaac M Westwood; Sanjib Bhakta; Angela J Russell; Elizabeth Fullam; Matthew C Anderton; Akane Kawamura; Andrew W Mulvaney; Richard J Vickers; Veemal Bhowruth; Gurdyal S Besra; Ajit Lalvani; Stephen G Davies; Edith Sim
Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.
Protein & cell 2010;1(1):82-95.
2010: Gabriel Bricard; Venkataswamy Manjunatha; Karl O A Yu; Jin S Im; Rachel M Ndonye; Amy R Howell; Natacha Veerapen; Petr A Illarionov; Gurdyal S Besra; Qian Li; Young-Tae Chang; Steven A Porcelli
Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents.
PloS one 2010;5(12):e14374.
2010: Yanmin Hu; Robert van der Geize; Gurdyal S Besra; Sudagar S Gurcha; Alexander Liu; Manfred Rohde; Mahavir Singh; Anthony Coates
3-Ketosteroid 9alpha-hydroxylase is an essential factor in the pathogenesis of Mycobacterium tuberculosis.
Molecular microbiology 2010;75(1):107-21.
2009: Jiemin Chen; Jordan Kriakov; Albel Singh; William R. Jacobs Jr.; Gurdyal S Besra; Apoorva Bhatt
Defects in glycopeptidolipid biosynthesis confer phage I3 resistance in Mycobacterium smegmatis.
Microbiology (Reading, England) 2009;155(Pt 12):4050-7.
2009: Lisa Michelle Fox; Daryl G Cox; Jennifer L Lockridge; Xiaohua Wang; Xiuxu Chen; Louise Scharf; David L Trott; Rachel M Ndonye; Natacha Veerapen; Gurdyal S Besra; Amy R Howell; Mark E Cook; Erin J Adams; William H Hildebrand; Jenny E Gumperz
Recognition of lyso-phospholipids by human natural killer T lymphocytes.
PLoS biology 2009;7(10):e1000228.
2009: Nicole N Driessen; Roy Ummels; JJ Maaskant; Sudagar S Gurcha; Gurdyal S Besra; Gary D Ainge; David S Larsen; Gavin F Painter; Christina M.J.E, Vandenbroucke-Grauls; Jeroen Geurtsen; Ben J Appelmelk
Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN.
Infection and immunity 2009;77(10):4538-47.
2009: Claire A Swetman Andersen; Ida Rosenkrands; Anja W Olsen; Pernille Nordly; Dennis Christensen; Roland Lang; Carsten Kirschning; Jessica M Gomes; Veemal Bhowruth; David E Minnikin; Gurdyal S Besra; Frank Follmann; Peter Andersen; Else Marie Agger
Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2294-302.
2009: Venkataswamy Manjunatha; Andres Baena; Michael F Goldberg; Gabriel Bricard; Jin S Im; John Chan; Faye Reddington; Gurdyal S Besra; William R. Jacobs Jr.; Steven A Porcelli
Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1644-56.
2009: Natacha Veerapen; Manfred Brigl; Salil Garg; Vincenzo Cerundolo; Liam R Cox; Michael B Brenner; Gurdyal S Besra
Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.
Bioorganic & medicinal chemistry letters 2009;19(15):4288-91.
2009: Helen L Birch; Luke Alderwick; Doris Rittmann; Karin Krumbach; Helga Etterich; Anna Grzegorzewicz; Michael R McNeil; Lothar Eggeling; Gurdyal S Besra
Identification of a terminal rhamnopyranosyltransferase (RptA) involved in Corynebacterium glutamicum cell wall biosynthesis.
Journal of bacteriology 2009;191(15):4879-87.
2009: Geetha Velmourougane; Ravinder Raju; Gabriel Bricard; Jin S Im; Gurdyal S Besra; Steven A Porcelli; Amy R Howell
Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH.
Bioorganic & medicinal chemistry letters 2009;19(13):3386-8.
2009: Arun K Mishra; Sarah Batt; Karin Krumbach; Lothar Eggeling; Gurdyal S Besra
Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis.
Journal of bacteriology 2009;191(13):4465-72.
2009: Jordi B Torrelles; Lucy E DesJardin; Jessica MacNeil; Thomas M Kaufman; Beth Kutzbach; Rose Knaup; Travis R McCarthy; Sudagar S Gurcha; Gurdyal S Besra; Steven Clegg; Larry S Schlesinger
Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death.
Glycobiology 2009;19(7):743-55.
2009: Jin S Im; Pooja Arora; Gabriel Bricard; Alberto Molano; Venkataswamy Manjunatha; Ian Baine; Elliot S Jerud; Michael F Goldberg; Andres Baena; Karl O A Yu; Rachel M Ndonye; Amy R Howell; Weiming Yuan; Peter Cresswell; Young-Tae Chang; Petr A Illarionov; Gurdyal S Besra; Steven A Porcelli
Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation.
Immunity 2009;30(6):888-98.
2009: Rachel D Kuns; Edward S Morris; Kelli P A MacDonald; Kate A Markey; Helen M Morris; Neil C Raffelt; Tatjana Banovic; Alistair L Don; Vanessa Rowe; Angela C Burman; Andrew D Clouston; Camile Farah; Gurdyal S Besra; Petr A Illarionov; Mark J Smyth; Steven A Porcelli; Geoffrey R Hill
Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration.
Blood 2009;113(23):5999-6010.
2009: Veeraraghavan Usha; Lynn Dover; David I Roper; Klaus Fütterer; Gurdyal S Besra
Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 4):383-7.
2009: Stéphanie Bessoles; Sherri Dudal; Gurdyal S Besra; Françoise Sanchez; Virginie Lafont
Human CD4+ invariant NKT cells are involved in antibacterial immunity against Brucella suis through CD1d-dependent but CD4-independent mechanisms.
European journal of immunology 2009;39(4):1025-35.
2009: Veemal Bhowruth; David E Minnikin; Else Marie Agger; Peter Andersen; Vincent W Bramwell; Yvonne Perrie; Gurdyal S Besra
Adjuvant properties of a simplified C32 monomycolyl glycerol analogue.
Bioorganic & medicinal chemistry letters 2009;19(7):2029-32.
2009: Romain Veyron-Churlet; Virginie Molle; Rebecca C Taylor; Alistair K Brown; Gurdyal S Besra; Isabelle Zanella-Cléon; Klaus Fütterer; Laurent Kremer
The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue.
The Journal of biological chemistry 2009;284(10):6414-24.
2009: Carole Guillonneau; Justine D Mintern; FX Hubert; Aeron C Hurt; Gurdyal S Besra; Steven A Porcelli; Ian Barr; Peter C Doherty; Dale I Godfrey; Stephen J Turner
Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3330-5.
2009: Ashish K Pathak; Vibha Pathak; William J Suling; James R Riordan; Sudagar S Gurcha; Gurdyal S Besra; Robert C Reynolds
Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry 2009;17(2):872-81.
2009: Alistair K Brown; Rebecca C Taylor; Apoorva Bhatt; Klaus Fütterer; Gurdyal S Besra
Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases.
PloS one 2009;4(7):e6306.
2009: Qosay Al-Balas; Nahoum Anthony; Bilal Al-Jaidi; A Alnimr; Grainne Abbott; Alistair K Brown; Rebecca C Taylor; Gurdyal S Besra; Timothy D McHugh; Stephen H Gillespie; Blair Johnston; Simon P Mackay; Geoffrey D Coxon
Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH.
PloS one 2009;4(5):e5617.
2009: Claire Swetman Andersen; Else Marie Agger; Ida Rosenkrands; Jessica M Gomes; Veemal Bhowruth; Kevin J C Gibson; Rune V Petersen; David E Minnikin; Gurdyal S Besra; Peter Andersen
A simple mycobacterial monomycolated glycerol lipid has potent immunostimulatory activity.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):424-32.
2008: Carmela De Santo; Mariolina Salio; S Hajar Masri; Laurel Yong-Hwa Lee; Tao Dong; Anneliese O Speak; Stefan Porubsky; Sarah Booth; Natacha Veerapen; Gurdyal S Besra; Hermann-Josef Gröne; Frances M Platt; Maria Zambon; Vincenzo Cerundolo
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
The Journal of clinical investigation 2008;118(12):4036-48.
2008: Xiaohua Wang; Xiuxu Chen; Lance Rodenkirch; William T N Simonson; Sarah Wernimont; Rachel M Ndonye; Natacha Veerapen; Darren Gibson; Amy R Howell; Gurdyal S Besra; Gavin F Painter; Anna Huttenlocher; Jenny E Gumperz
Natural killer T-cell autoreactivity leads to a specialized activation state.
Blood 2008;112(10):4128-38.
2008: David S Leslie; Christopher Dascher; Katherine Cembrola; Maria A Townes; David L Hava; Lynne C Hugendubler; Elisabetta Mueller; Lisa Michelle Fox; Carme Roura-Mir; D Branch Moody; Michael S Vincent; Jenny E Gumperz; Petr A Illarionov; Gurdyal S Besra; Carol G Reynolds; Michael B Brenner
Serum lipids regulate dendritic cell CD1 expression and function.
Immunology 2008;125(3):289-301.
2008: Apoorva Bhatt; Alistair K Brown; Albel Singh; David E Minnikin; Gurdyal S Besra
Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones.
Chemistry & biology 2008;15(9):930-9.
2008: Ricardo Lucas; Patricia Balbuena; James Errey; Marie A Squire; Sudagar S Gurcha; Michael McNeil; Gurdyal S Besra; Benjamin G Davis
Glycomimetic inhibitors of mycobacterial glycosyltransferases: targeting the TB cell wall.
Chembiochem : a European journal of chemical biology 2008;9(14):2197-9.
2008: Julie M Fletcher; Margaret A Jordan; Sarah L Snelgrove; Robyn M Slattery; François D Dufour; Konstantinos Kyparissoudis; Gurdyal S Besra; Dale I Godfrey; Alan G Baxter
Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3400-12.
2008: Helen L Birch; Luke Alderwick; Apoorva Bhatt; Doris Rittmann; Karin Krumbach; Albel Singh; Yu Bai; Todd L Lowary; Lothar Eggeling; Gurdyal S Besra
Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferase.
Molecular microbiology 2008;69(5):1191-206.
2008: Veemal Bhowruth; Luke Alderwick; Alistair K Brown; Apoorva Bhatt; Gurdyal S Besra
Tuberculosis: a balanced diet of lipids and carbohydrates.
Biochemical Society transactions 2008;36(Pt 4):555-65.
2008: Arun K Mishra; Christina Klein; Sudagar S Gurcha; Luke Alderwick; Ponnusamy Babu; Paul G Hitchen; Howard R Morris; Anne Dell; Gurdyal S Besra; Lothar Eggeling
Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB' mutant.
Antonie van Leeuwenhoek 2008;94(2):277-87.
2008: Veemal Bhowruth; Alistair K Brown; Gurdyal S Besra
Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636.
Microbiology (Reading, England) 2008;154(Pt 7):1866-75.
2008: Stéphanie Bessoles; Frédéric Fouret; Sherri Dudal; Gurdyal S Besra; Françoise Sanchez; Virginie Lafont
IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines.
Journal of leukocyte biology 2008;84(1):224-33.
2008: Patricia Barral; Julia Eckl-Dorna; Naomi E Harwood; Carmela De Santo; Mariolina Salio; Petr Illarionov; Gurdyal S Besra; Vincenzo Cerundolo; Facundo D Batista
B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(24):8345-50.
2008: Elizabeth A Leadbetter; Manfred Brigl; Petr A Illarionov; Nadia Cohen; Megan C Luteran; Shiv Pillai; Gurdyal S Besra; Michael B Brenner
NK T cells provide lipid antigen-specific cognate help for B cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(24):8339-44.
2008: Dave Sprengers; Fenna C M Sillé; Katja Derkow; Gurdyal S Besra; Harry L A Janssen; Eckart Schott; Marianne Boes
Critical role for CD1d-restricted invariant NKT cells in stimulating intrahepatic CD8 T-cell responses to liver antigen.
Gastroenterology 2008;134(7):2132-43.
2008: Dee N Dao; Kari Sweeney; Tsungda Hsu; Sudagar S Gurcha; Ivan P Nascimento; Dan Roshevsky; Gurdyal S Besra; John Chan; Steven A Porcelli; William R. Jacobs Jr.
Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.
PLoS pathogens 2008;4(6):e1000081.
2008: Arun K Mishra; Luke Alderwick; Doris Rittmann; Cindy Wang; Apoorva Bhatt; William R. Jacobs Jr.; Kuni Takayama; Lothar Eggeling; Gurdyal S Besra
Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.
Molecular microbiology 2008;68(6):1595-613.
2008: Jerome Nigou; Thierry Vasselon; Aurélie Ray; Patricia Constant; Martine GILLERON; Gurdyal S Besra; Iain C Sutcliffe; Gérard Tiraby; Germain Puzo
Mannan chain length controls lipoglycans signaling via and binding to TLR2.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6696-702.
2008: Jonathan Silk; Mariolina Salio; Gopal R Bommineni; Dawn Shepherd; Uzi Gileadi; James Brown; S Hajar Masri; Paolo Polzella; Gerd Ritter; Gurdyal S Besra; E Yvonne Jones; Richard R Schmidt; Vincenzo Cerundolo
Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6452-6.
2008: Lynn G Dover; Apoorva Bhatt; Veemal Bhowruth; Benjamin E Willcox; Gurdyal S Besra
New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections.
Expert review of vaccines 2008;7(4):481-97.
2008: Jin S Im; Tae-Jin Kang; Seong-Beom Lee; Chi-Hong Kim; Sang-Haak Lee; Venkataswamy Manjunatha; Evan R Serfass; Bing Chen; Petr A Illarionov; Gurdyal S Besra; William R. Jacobs Jr.; Gue-Tae Chae; Steven A Porcelli
Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections.
Clinical immunology (Orlando, Fla.) 2008;127(2):214-24.
2008: Alberto Molano; Petr A Illarionov; Gurdyal S Besra; Chaim Putterman; Steven A Porcelli
Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase.
Immunology letters 2008;117(1):81-90.
2008: Natalie J Garton; Simon J Waddell; Anna L Sherratt; Su-Min Lee; Rebecca J Smith; Claire Senner; Jason Hinds; Kumar Rajakumar; Richard A Adegbola; Gurdyal S Besra; Philip Butcher; Michael R Barer
Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum.
PLoS medicine 2008;5(4):e75.
2008: Luke Alderwick; Lynn Dover; Natacha Veerapen; Sudagar S Gurcha; Laurent Kremer; David L Roper; Ashish K Pathak; Robert C Reynolds; Gurdyal S Besra
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.
Protein expression and purification 2008;58(2):332-41.
2008: Yanmin Hu; Brian Henderson; Peter Lund; Peter Tormay; M Tabish Ahmed; Sudagar S Gurcha; Gurdyal S Besra; Anthony R M Coates
A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection.
Infection and immunity 2008;76(4):1535-46.
2008: Veeraraghavan Usha; Lynn Dover; David L Roper; Gurdyal S Besra
Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization.
FEMS microbiology letters 2008;280(1):57-63.
2008: Kathrin Stirnemann; Jackeline F Romero; Lucia Baldi; Bruno Robert; Valérie Cesson; Gurdyal S Besra; Maurice Zauderer; Florian Wurm; Giampietro Corradin; Jean-Pierre Mach; H Robson MacDonald; Alena Donda
Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice.
The Journal of clinical investigation 2008;118(3):994-1005.
2008: Galit Denkberg; Victoria S Stronge; Efrat Zahavi; Paola Pittoni; Ravit Oren; Dawn Shepherd; Mariolina Salio; Corinna McCarthy; Petr A Illarionov; Philip van der Merwe; Gurdyal S Besra; Paolo Dellabona; Giulia Casorati; Vincenzo Cerundolo; Yoram Reiter
Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules.
European journal of immunology 2008;38(3):829-40.
2008: Paul Gratraud; Namita Surolia; Gurdyal S Besra; Avadhesha Surolia; Laurent Kremer
Antimycobacterial Activity and Mechanism of Action of NAS-91.
Antimicrobial agents and chemotherapy 2008;52(3):1162-6.
2008: Virginie Molle; Robert C Reynolds; Luke Alderwick; Gurdyal S Besra; Alain J Cozzone; Klaus Fütterer; Laurent Kremer
EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR.
The Biochemical journal 2008;410(2):309-17.
2008: Pui-Hang Tam; Gurdyal S Besra; Todd L Lowary
Exploring the substrate specificity of a mycobacterial polyprenol monophosphomannose-dependent alpha-(1-->6)-mannosyltransferase.
Chembiochem : a European journal of chemical biology 2008;9(2):267-78.
2008: Joanne E Croudace; Stuart M Curbishley; Manuela Mura; Carrie R Willcox; Petr A Illarionov; Gurdyal S Besra; David H Adams; David A Lammas
Identification of distinct human invariant natural killer T-cell response phenotypes to alpha-galactosylceramide.
BMC immunology 2008;9():71.
2008: Israel Hershkovitz; Helen D Donoghue; David E Minnikin; Gurdyal S Besra; Oona Ying-Chi Lee; Angela M Gernaey; Ehud Galili; Vered Eshed; Charles L Greenblatt; Eshetu Lemma; Gila Kahila Bar-Gal; Mark Spigelman
Detection and molecular characterization of 9,000-year-old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern Mediterranean.
PloS one 2008;3(10):e3426.
2008: Kanhu C Mishra; Chantal de Chastellier; Yeddula Narayana; Pablo Bifani; Alistair K Brown; Gurdyal S Besra; Vishwa M Katoch; Beenu Joshi; Kithiganahalli N Balaji; Laurent Kremer
Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY.
Infection and immunity 2008;76(1):127-40.
2008: Marcus Niemeyer; Alexandre Darmoise; Hans-Joachim Mollenkopf; Karin Hahnke; Robert Hurwitz; Gurdyal S Besra; Ulrich E Schaible; Stefan H E Kaufmann
Natural killer T-cell characterization through gene expression profiling: an account of versatility bridging T helper type 1 (Th1), Th2 and Th17 immune responses.
Immunology 2008;123(1):45-56.
2007: Mariolina Salio; Anneliese O Speak; Dawn Shepherd; Paolo Polzella; Petr A Illarionov; Natacha Veerapen; Gurdyal S Besra; Frances M Platt; Vincenzo Cerundolo
Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(51):20490-5.
2007: Alistair K Brown; Apoorva Bhatt; Albel Singh; Elesh Saparia; Alex F Evans; Gurdyal S Besra
Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex.
Microbiology (Reading, England) 2007;153(Pt 12):4166-73.
2007: Xiuxu Chen; Xiaohua Wang; Gurdyal S Besra; Jenny E Gumperz
Modulation of CD1d-restricted NKT cell responses by CD4.
Journal of leukocyte biology 2007;82(6):1455-65.
2007: Finlay W McNab; Daniel G Pellicci; Kenneth Field; Gurdyal S Besra; Mark J Smyth; Dale I Godfrey; Stuart P Berzins
Peripheral NK1.1 NKT cells are mature and functionally distinct from their thymic counterparts.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6630-7.
2007: Luke Alderwick; H L Birch; Arun K Mishra; Lothar Eggeling; Gurdyal S Besra
Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new drug targets.
Biochemical Society transactions 2007;35(Pt 5):1325-8.
2007: Qian Li; Rachel M Ndonye; Petr A Illarionov; Karl O A Yu; Elliot S Jerud; Kristine Diaz; Gabriel Bricard; Steven A Porcelli; Gurdyal S Besra; Young-Tae Chang; Amy R Howell
Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries.
Journal of combinatorial chemistry 2007;9(6):1084-93.
2007: Ban Al-Sayyed; Sajida Piperdi; Xinni Yuan; Anping Li; Gurdyal S Besra; William R. Jacobs Jr.; Arturo Casadevall; Aharona Glatman-Freedman
Monoclonal antibodies to Mycobacterium tuberculosis CDC 1551 reveal subcellular localization of MPT51.
Tuberculosis (Edinburgh, Scotland) 2007;87(6):489-97.
2007: Christina Vafiadi; Evangelos Topakas; Luke Alderwick; Gurdyal S Besra; Paul Christakopoulos
Chemoenzymatic synthesis of feruloyl D-arabinose as a potential anti-mycobacterial agent.
Biotechnology letters 2007;29(11):1771-4.
2007: Veemal Bhowruth; Alistair K Brown; Suzanne J Senior; John S Snaith; Gurdyal S Besra
Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library.
Bioorganic & medicinal chemistry letters 2007;17(20):5643-6.
2007: Hemza Ghadbane; Alistair K Brown; Laurent Kremer; Gurdyal S Besra; Klaus Fütterer
Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT).
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 10):831-5.
2007: Alistair K Brown; Athina Papaemmanouil; Veemal Bhowruth; Apoorva Bhatt; Lynn Dover; Gurdyal S Besra
Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.
Microbiology (Reading, England) 2007;153(Pt 10):3314-22.
2007: Arun K Mishra; Luke Alderwick; Doris Rittmann; Raju V V Tatituri; Jerome Nigou; Martine GILLERON; Lothar Eggeling; Gurdyal S Besra
Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis.
Molecular microbiology 2007;65(6):1503-17.
2007: Ashish K Pathak; Vibha Pathak; James R Riordan; William J Suling; Sudagar S Gurcha; Gurdyal S Besra; Robert C Reynolds
Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 2007;17(16):4527-30.
2007: Ashish K Pathak; Vibha Pathak; Lainne E Seitz; Sudagar S Gurcha; Gurdyal S Besra; James M Riordan; Robert C Reynolds
Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry 2007;15(16):5629-50.
2007: Michele W L Teng; Jennifer A Westwood; Phillip K Darcy; Janelle Sharkey; Moriya Tsuji; Richard W Franck; Steven A Porcelli; Gurdyal S Besra; Kazuyoshi Takeda; Hideo Yagita; Michael H Kershaw; Mark J Smyth
Combined natural killer T-cell based immunotherapy eradicates established tumors in mice.
Cancer research 2007;67(15):7495-504.
2007: Raju V V Tatituri; Luke Alderwick; Arun K Mishra; Jerome Nigou; Martine GILLERON; Karin Krumbach; Paul G Hitchen; Assunta Giordano; Howard R Morris; Anne Dell; Lothar Eggeling; Gurdyal S Besra
Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant.
Microbiology (Reading, England) 2007;153(Pt 8):2621-9.
2007: Sharon L Kendall; Mike Withers; Catherine N Soffair; Nicole J Moreland; Sudagar Gurcha; Ben Sidders; Rosangela Frita; Annemieke M.C. ten Bokum; Gurdyal S Besra; J Shaun Lott; neil stoker
A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis.
Molecular microbiology 2007;65(3):684-99.
2007: Natalie A Borg; Kwok S Wun; Lars Kjer-Nielsen; Matthew C J Wilce; Daniel G Pellicci; Ruide Koh; Gurdyal S Besra; Mandvi Bharadwaj; Dale I Godfrey; James McCluskey; Jamie Rossjohn
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.
Nature 2007;448(7149):44-9.
2007: Roland Gande; Lynn Dover; Karin Krumbach; Gurdyal S Besra; Hermann Sahm; Tadao Oikawa; Lothar Eggeling
The two carboxylases of Corynebacterium glutamicum essential for fatty acid and mycolic acid synthesis.
Journal of bacteriology 2007;189(14):5257-64.
2007: Apoorva Bhatt; Virginie Molle; Gurdyal S Besra; William R. Jacobs Jr.; Laurent Kremer
The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development.
Molecular microbiology 2007;64(6):1442-54.
2007: Karl O A Yu; Jin S Im; Petr A Illarionov; Rachel M Ndonye; Amy R Howell; Gurdyal S Besra; Steven A Porcelli
Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d.
Journal of immunological methods 2007;323(1):11-23.
2007: Mathias Seidel; Luke Alderwick; Helen L Birch; Hermann Sahm; Lothar Eggeling; Gurdyal S Besra
Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum and Mycobacterium tuberculosis.
The Journal of biological chemistry 2007;282(20):14729-40.
2007: Xiuxu Chen; Xiaohua Wang; Jason M Keaton; Faye Reddington; Petr A Illarionov; Gurdyal S Besra; Jenny E Gumperz
Distinct endosomal trafficking requirements for presentation of autoantigens and exogenous lipids by human CD1d molecules.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6181-90.
2007: Corinna McCarthy; Dawn Shepherd; Sebastian Fleire; Victoria S Stronge; Michael Koch; Petr A Illarionov; Giovanna Bossi; Mariolina Salio; Galit Denkberg; Faye Reddington; Andrea Tarlton; Gopal R Bommineni; Richard R Schmidt; Yoram Reiter; Gillian M Griffiths; Philip van der Merwe; Gurdyal S Besra; E Yvonne Jones; Facundo D Batista; Vincenzo Cerundolo
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.
The Journal of experimental medicine 2007;204(5):1131-44.
2007: Lynn Dover; Luke Alderwick; Alistair K Brown; Klaus Futterer; Gurdyal S Besra
Regulation of cell wall synthesis and growth.
Current molecular medicine 2007;7(3):247-76.
2007: Joanna Bacon; Lynn Dover; Kim A Hatch; Yi Zhang; Jessica M Gomes; Sharon Kendall; Lorenz Wernisch; neil stoker; Philip Butcher; Gurdyal S Besra; Philip D Marsh
Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester.
Microbiology (Reading, England) 2007;153(Pt 5):1435-44.
2007: Subramanya Hegde; Xiuxu Chen; Jason M Keaton; Faye Reddington; Gurdyal S Besra; Jenny E Gumperz
NKT cells direct monocytes into a DC differentiation pathway.
Journal of leukocyte biology 2007;81(5):1224-35.
2007: Weiming Yuan; Xiaoyang Qi; Pansy Tsang; Suk-Jo Kang; Petr A Illarionov; Petr A Illaniorov; Gurdyal S Besra; Jenny E Gumperz; Peter Cresswell
Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5551-6.
2007: Apoorva Bhatt; Nagatoshi Fujiwara; Kiranmai Bhatt; Sudagar S Gurcha; Laurent Kremer; Bing Chen; John Chan; Steven A Porcelli; Kazuo Kobayashi; Gurdyal S Besra; William R. Jacobs Jr.
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5157-62.
2007: Jonathan M Coquet; Konstantinos Kyparissoudis; Daniel G Pellicci; Gurdyal S Besra; Stuart P Berzins; Mark J Smyth; Dale I Godfrey
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2827-34.
2007: Huiping Ren; Lynn Dover; Salim T Islam; David C Alexander; Jeffrey M Chen; Gurdyal S Besra; Jun Liu
Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum.
Molecular microbiology 2007;63(5):1345-59.
2007: Lynn Dover; Anuradha Alahari; Paul Gratraud; Jessica M Gomes; Veemal Bhowruth; Robert C Reynolds; Gurdyal S Besra; Laurent Kremer
EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.
Antimicrobial agents and chemotherapy 2007;51(3):1055-63.
2007: Raju V V Tatituri; Petr A Illarionov; Lynn Dover; Jerome Nigou; Martine GILLERON; Paul G Hitchen; Karin Krumbach; Howard R Morris; Neil Spencer; Anne Dell; Lothar Eggeling; Gurdyal S Besra
Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis.
The Journal of biological chemistry 2007;282(7):4561-72.
2007: sudharsan sridharan; Lei Wang; Alistair K Brown; Lynn Dover; Laurent Kremer; Gurdyal S Besra; James C Sacchettini
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).
Journal of molecular biology 2007;366(2):469-80.
2007: Kiranmai Bhatt; Sudagar S Gurcha; Apoorva Bhatt; Gurdyal S Besra; William R. Jacobs Jr.
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
Microbiology (Reading, England) 2007;153(Pt 2):513-20.
2007: Claire Forestier; Toshiyuki Takaki; Alberto Molano; Jin S Im; Ian Baine; Elliot S Jerud; Petr A Illarionov; Rachel M Ndonye; Amy R Howell; Pere Santamaria; Gurdyal S Besra; Teresa P DiLorenzo; Steven A Porcelli
Improved outcomes in NOD mice treated with a novel Th2 cytokine-biasing NKT cell activator.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1415-25.
2007: Mathias Seidel; Luke Alderwick; Hermann Sahm; Gurdyal S Besra; Lothar Eggeling
Topology and mutational analysis of the single Emb arabinofuranosyltransferase of Corynebacterium glutamicum as a model of Emb proteins of Mycobacterium tuberculosis.
Glycobiology 2007;17(2):210-9.
2007: Feng Wang; Robert Langley; Gulcin Gulten; Lynn Dover; Gurdyal S Besra; William R. Jacobs Jr.; James C Sacchettini
Mechanism of thioamide drug action against tuberculosis and leprosy.
The Journal of experimental medicine 2007;204(1):73-8.
2007: Anuradha Alahari; Xavier Trivelli; Yann Guérardel; Lynn Dover; Gurdyal S Besra; James C Sacchettini; Robert C Reynolds; Geoffrey D Coxon; Laurent Kremer
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.
PloS one 2007;2(12):e1343.
2007: Alistair K Brown; Guoyu Meng; Hemza Ghadbane; David Scott; Lynn Dover; Jerome Nigou; Gurdyal S Besra; Klaus Fütterer
Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+.
BMC structural biology 2007;7():55.
2007: Veemal Bhowruth; Lynn Dover; Gurdyal S Besra
Tuberculosis chemotherapy: recent developments and future perspectives.
Progress in medicinal chemistry 2007;45():169-203.
2007: Stanislav Gobec; Ivan Plantan; Janez Mravljak; Urban Svajger; Rosalind A Wilson; Gurdyal S Besra; Sousana L Soares; Rui Appelberg; Danijel Kikelj
Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall.
European journal of medicinal chemistry 2007;42(1):54-63.
2006: Crina Paduraru; Laurentiu Spiridon; Weiming Yuan; Gabriel Bricard; Xavier Valencia; Steven A Porcelli; Petr A Illarionov; Gurdyal S Besra; Stefana M Petrescu; Andrei J Petrescu; Peter Cresswell
An N-linked glycan modulates the interaction between the CD1d heavy chain and beta 2-microglobulin.
The Journal of biological chemistry 2006;281(52):40369-78.
2006: Peter J Kim; Sung-Yun Pai; Manfred Brigl; Gurdyal S Besra; Jenny E Gumperz; I-Cheng Ho
GATA-3 regulates the development and function of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6650-9.
2006: Luke Alderwick; Lynn Dover; Mathias Seidel; Roland Gande; Hermann Sahm; Lothar Eggeling; Gurdyal S Besra
Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-D-arabinose metabolism.
Glycobiology 2006;16(11):1073-81.
2006: Jin S Im; Nikos Tapinos; Gue-Tae Chae; Petr A Illarionov; Gurdyal S Besra; George Henry De Vries; Robert L Modlin; Peter Allan Sieling; Anura Rambukkana; Steven A Porcelli
Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5226-35.
2006: Virginie Molle; Alistair K Brown; Gurdyal S Besra; Alain J Cozzone; Laurent Kremer
The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.
The Journal of biological chemistry 2006;281(40):30094-103.
2006: Stephan D Gadola; Jonathan Silk; Aruna Jeans; Petr A Illarionov; Mariolina Salio; Gurdyal S Besra; Raymond A Dwek; Terry D Butters; Frances M Platt; Vincenzo Cerundolo
Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.
The Journal of experimental medicine 2006;203(10):2293-303.
2006: Istvan Szatmari; Attila Pap; Ralph Rühl; Jiang-Xing Ma; Petr A Illarionov; Gurdyal S Besra; Eva Rajnavolgyi; Balazs Dezso; Laszlo Nagy
PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells.
The Journal of experimental medicine 2006;203(10):2351-62.
2006: Veemal Bhowruth; Alistair K Brown; Robert C Reynolds; Geoffrey D Coxon; Simon P Mackay; David E Minnikin; Gurdyal S Besra
Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 2006;16(18):4743-7.
2006: Yi-Guang Chen; Jing Chen; Melissa A Osborne; Harold D Chapman; Gurdyal S Besra; Steven A Porcelli; Edward H Leiter; S Brian Wilson; David V Serreze
CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):2939-47.
2006: Veeraraghavan Usha; Lynn Dover; David L Roper; Adrian Lloyd; Gurdyal S Besra
Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase.
FEMS microbiology letters 2006;262(1):39-47.
2006: Andreja Kovac; Rosalind A Wilson; Gurdyal S Besra; Metka Filipic; Danijel Kikelj; Stanislav Gobec
New lipophilic phthalimido- and 3-phenoxybenzyl sulfonates: inhibition of antigen 85C mycolyltransferase activity and cytotoxicity.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):391-7.
2006: Tan-Yun Cheng; Miguel Relloso; Ildiko Van Rhijn; David C Young; Gurdyal S Besra; Volker Briken; Dirk Zajonc; Ian A Wilson; Steven A Porcelli; D Branch Moody
Role of lipid trimming and CD1 groove size in cellular antigen presentation.
The EMBO journal 2006;25(13):2989-99.
2006: Luke Alderwick; Mathias Seidel; Hermann Sahm; Gurdyal S Besra; Lothar Eggeling
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis.
The Journal of biological chemistry 2006;281(23):15653-61.
2006: Maju Joe; Daniel Sun; Hashem Taha; Gladys Completo; Joanne E Croudace; David A Lammas; Gurdyal S Besra; Todd L Lowary
The 5-deoxy-5-methylthio-xylofuranose residue in mycobacterial lipoarabinomannan. absolute stereochemistry, linkage position, conformation, and immunomodulatory activity.
Journal of the American Chemical Society 2006;128(15):5059-72.
2006: Ildiko Van Rhijn; Ad P Koets; Jin S Im; Diewertje Piebes; Faye Reddington; Gurdyal S Besra; Steven A Porcelli; Willem van Eden; V P M G Rutten
The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4888-93.
2006: Lars Kjer-Nielsen; Natalie A Borg; Daniel G Pellicci; Travis Beddoe; Lyudmila Kostenko; Craig S Clements; Nicholas A Williamson; Mark J Smyth; Gurdyal S Besra; Hugh Reid; Mandvi Bharadwaj; Dale I Godfrey; Jamie Rossjohn; James McCluskey
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.
The Journal of experimental medicine 2006;203(3):661-73.
2006: Manfred Brigl; Peter van den Elzen; Xiuxu Chen; Jennifer Hartt Meyers; Douglass Wu; Chi-Huey Wong; Faye Reddington; Petr A Illarianov; Gurdyal S Besra; Michael B Brenner; Jenny E Gumperz
Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3625-34.
2006: Luke Alderwick; Virginie Molle; Laurent Kremer; Alain J Cozzone; Timothy R Dafforn; Gurdyal S Besra; Klaus Fütterer
Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2558-63.
2006: Matthew C Anderton; Sanjib Bhakta; Gurdyal S Besra; Peter Jeavons; Lindsay D Eltis; Edith Sim
Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG.
Molecular microbiology 2006;59(1):181-92.
2005: Adeline Burguière; Paul G Hitchen; Lynn Dover; Laurent Kremer; Malin Ridell; David C Alexander; Jun Liu; Howard R Morris; David E Minnikin; Anne Dell; Gurdyal S Besra
LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum.
The Journal of biological chemistry 2005;280(51):42124-33.
2005: Peter van den Elzen; Salil Garg; Luis León; Manfred Brigl; Elizabeth A Leadbetter; Jenny E Gumperz; Christopher Dascher; Tan-Yun Cheng; Frank M Sacks; Petr A Illarionov; Gurdyal S Besra; Sally C Kent; D Branch Moody; Michael B Brenner
Apolipoprotein-mediated pathways of lipid antigen presentation.
Nature 2005;437(7060):906-10.
2005: Alistair K Brown; sudharsan sridharan; Laurent Kremer; Sandra Lindenberg; Lynn Dover; James C Sacchettini; Gurdyal S Besra
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
The Journal of biological chemistry 2005;280(37):32539-47.
2005: Luke Alderwick; Eva Radmacher; Mathias Seidel; Roland Gande; Paul G Hitchen; Howard R Morris; Anne Dell; Hermann Sahm; Lothar Eggeling; Gurdyal S Besra
Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core.
The Journal of biological chemistry 2005;280(37):32362-71.
2005: Markus Sköld; Xiaowei Xiong; Petr A Illarionov; Gurdyal S Besra; Samuel M Behar
Interplay of cytokines and microbial signals in regulation of CD1d expression and NKT cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3584-93.
2005: Kevin J C Gibson; Martine GILLERON; Patricia Constant; Bénédicte Sichi; Germain Puzo; Gurdyal S Besra; Jerome Nigou
A lipomannan variant with strong TLR-2-dependent pro-inflammatory activity in Saccharothrix aerocolonigenes.
The Journal of biological chemistry 2005;280(31):28347-56.
2005: Laurent Kremer; Chantal de Chastellier; Gary Dobson; Kevin J C Gibson; Pablo Bifani; Stéphanie Balor; Jean-Pierre Gorvel; Camille Locht; David E Minnikin; Gurdyal S Besra
Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol.
Molecular microbiology 2005;57(4):1113-26.
2005: Michael Koch; Victoria S Stronge; Dawn Shepherd; Stephan D Gadola; Bini Mathew; Gerd Ritter; Alan Fersht; Gurdyal S Besra; Richard R Schmidt; E Yvonne Jones; Vincenzo Cerundolo
The crystal structure of human CD1d with and without alpha-galactosylceramide.
Nature immunology 2005;6(8):819-26.
2005: Claire Forestier; Alberto Molano; Jin S Im; Yves Dutronc; Betty Diamond; Anne Davidson; Petr A Illarionov; Gurdyal S Besra; Steven A Porcelli
Expansion and hyperactivity of CD1d-restricted NKT cells during the progression of systemic lupus erythematosus in (New Zealand Black x New Zealand White)F1 mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):763-70.
2005: Eva Radmacher; Luke Alderwick; Gurdyal S Besra; Alistair K Brown; Kevin J C Gibson; Hermann Sahm; Lothar Eggeling
Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum.
Microbiology (Reading, England) 2005;151(Pt 7):2421-7.
2005: Gillian A Lang; Petr A Illarionov; Aharona Glatman-Freedman; Gurdyal S Besra; Mark L Lang
BCR targeting of biotin-{alpha}-galactosylceramide leads to enhanced presentation on CD1d and requires transport of BCR to CD1d-containing endocytic compartments.
International immunology 2005;17(7):899-908.
2005: Adeline Burguière; Paul G Hitchen; Lynn Dover; Anne Dell; Gurdyal S Besra
Altered expression profile of mycobacterial surface glycopeptidolipids following treatment with the antifungal azole inhibitors econazole and clotrimazole.
Microbiology (Reading, England) 2005;151(Pt 6):2087-95.
2005: Eva Radmacher; Kathrin C Stansen; Gurdyal S Besra; Luke Alderwick; William N Maughan; Günter Hollweg; Hermann Sahm; Volker F Wendisch; Lothar Eggeling
Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits L-glutamate efflux of Corynebacterium glutamicum.
Microbiology (Reading, England) 2005;151(Pt 5):1359-68.
2005: Grant S Hotter; Barry J Wards; Pania Mouat; Gurdyal S Besra; Jessica Gomes; Monica Singh; Shalome Bassett; Pamela Kawakami; Paul R Wheeler; Geoffrey W de Lisle; Desmond M Collins
Transposon mutagenesis of Mb0100 at the ppe1-nrp locus in Mycobacterium bovis disrupts phthiocerol dimycocerosate (PDIM) and glycosylphenol-PDIM biosynthesis, producing an avirulent strain with vaccine properties at least equal to those of M. bovis BCG.
Journal of bacteriology 2005;187(7):2267-77.
2005: Carme Roura-Mir; Marta Catálfamo; Tan-Yun Cheng; Ellen Marqusee; Gurdyal S Besra; Dolores Jaraquemada; D Branch Moody
CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3773-80.
2005: Karl O A Yu; Jin S Im; Alberto Molano; Yves Dutronc; Petr A Illarionov; Claire Forestier; Nagatoshi Fujiwara; Isa Arias; Sachiko Miyake; Takashi Yamamura; Young-Tae Chang; Gurdyal S Besra; Steven A Porcelli
Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3383-8.
2005: Oana M Cociorva; Sudagar S Gurcha; Gurdyal S Besra; Todd L Lowary
Oligosaccharides as inhibitors of mycobacterial arabinosyltransferases. Di- and trisaccharides containing C-3 modified arabinofuranosyl residues.
Bioorganic & medicinal chemistry 2005;13(4):1369-79.
2005: Vinodhkumar Subramaniam; Sudagar S Gurcha; Gurdyal S Besra; Todd L Lowary
Modified mannose disaccharides as substrates and inhibitors of a polyprenol monophosphomannose-dependent alpha-(1-->6)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesis.
Bioorganic & medicinal chemistry 2005;13(4):1083-94.
2005: Yi-Guang Chen; Caroline-Morgane Choisy-Rossi; Thomas M Holl; Harold D Chapman; Gurdyal S Besra; Steven A Porcelli; Daniel Shaffer; Derry C Roopenian; S Brian Wilson; David V Serreze
Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1196-204.
2005: Simon J Waddell; G A Chung; Kevin J C Gibson; Martin J Everett; David E Minnikin; Gurdyal S Besra; Philip Butcher
Inactivation of polyketide synthase and related genes results in the loss of complex lipids in Mycobacterium tuberculosis H37Rv.
Letters in applied microbiology 2005;40(3):201-6.
2005: Kuni Takayama; Cindy Wang; Gurdyal S Besra
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.
Clinical microbiology reviews 2005;18(1):81-101.
2004: Isamu Matsunaga; Apoorva Bhatt; David C Young; Tan-Yun Cheng; Stephen J Eyles; Gurdyal S Besra; Volker Briken; Steven A Porcelli; Catherine E Costello; William R. Jacobs Jr.; D Branch Moody
Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells.
The Journal of experimental medicine 2004;200(12):1559-69.
2004: Roland Gande; Kevin J C Gibson; Alistair K Brown; Karin Krumbach; Lynn Dover; Hermann Sahm; Susumu Shioyama; Tadao Oikawa; Gurdyal S Besra; Lothar Eggeling
Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.
The Journal of biological chemistry 2004;279(43):44847-57.
2004: Joseph L Amprey; Jin S Im; Salvatore J Turco; Henry W Murray; Petr A Illarionov; Gurdyal S Besra; Steven A Porcelli; Gerald F Späth
A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan.
The Journal of experimental medicine 2004;200(7):895-904.
2004: Mark R Guy; Petr A Illarionov; Sudagar S Gurcha; Lynn Dover; Kevin J C Gibson; Paul W Smith; David E Minnikin; Gurdyal S Besra
Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.
The Biochemical journal 2004;382(Pt 3):905-12.
2004: Ildiko Van Rhijn; David C Young; Jin S Im; Steven B Levery; Petr A Illarionov; Gurdyal S Besra; Steven A Porcelli; Jenny E Gumperz; Tan-Yun Cheng; D Branch Moody
CD1d-restricted T cell activation by nonlipidic small molecules.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(37):13578-83.
2004: Sylvaine Cren; Sudagar S Gurcha; Alexander J Blake; Gurdyal S Besra; Neil R Thomas
Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase--a key enzyme in M. tuberculosis cell wall biosynthesis.
Organic & biomolecular chemistry 2004;2(17):2418-20.
2004: Donald Ronning; Varalakshmi D Vissa; Gurdyal S Besra; John Belisle; James C Sacchettini
Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity.
The Journal of biological chemistry 2004;279(35):36771-7.
2004: Stéphane Sidobre; Kirsten J L Hammond; Lise Bénazet-Sidobre; Sergei D Maltsev; Stewart K Richardson; Rachel M Ndonye; Amy R Howell; Teruyuki Sakai; Gurdyal S Besra; Steven A Porcelli; Mitchell Kronenberg
The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12254-9.
2004: Lynn Dover; Patrick E Corsino; Ian R Daniels; Sarah L Cocklin; Vijaya Tatituri; Gurdyal S Besra; Klaus Fütterer
Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance.
Journal of molecular biology 2004;340(5):1095-105.
2004: Stanislav Gobec; Ivan Plantan; Janez Mravljak; Rosalind A Wilson; Gurdyal S Besra; Danijel Kikelj
Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall.
Bioorganic & medicinal chemistry letters 2004;14(13):3559-62.
2004: Volker Briken; Steven A Porcelli; Gurdyal S Besra; Laurent Kremer
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
Molecular microbiology 2004;53(2):391-403.
2004: Gillian A Lang; Sergei D Maltsev; Gurdyal S Besra; Mark L Lang
Presentation of alpha-galactosylceramide by murine CD1d to natural killer T cells is facilitated by plasma membrane glycolipid rafts.
Immunology 2004;112(3):386-96.
2004: Kevin J C Gibson; Martine GILLERON; Patricia Constant; Thérèse Brando; Germain Puzo; Gurdyal S Besra; Jerome Nigou
Tsukamurella paurometabola lipoglycan, a new lipoarabinomannan variant with pro-inflammatory activity.
The Journal of biological chemistry 2004;279(22):22973-82.
2004: Sanjib Bhakta; Gurdyal S Besra; Anna M Upton; Tanya Parish; Carolyn Sholto-Douglas-Vernon; Kevin J C Gibson; Stuart Knutton; Siamon Gordon; Rosangela P DaSilva; Matthew C Anderton; Edith Sim
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target.
The Journal of experimental medicine 2004;199(9):1191-9.
2004: Lynn Dover; Ana Cerdeño-Tárraga; Mark J Pallen; Julian Parkhill; Gurdyal S Besra
Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae.
FEMS microbiology reviews 2004;28(2):225-50.
2004: Ashish K Pathak; Vibha Pathak; James M Riordan; Sudagar S Gurcha; Gurdyal S Besra; Robert C Reynolds
Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis.
Carbohydrate research 2004;339(3):683-91.
2004: Thil Batuwangala; Dawn Shepherd; Stephan D Gadola; Kevin J C Gibson; Nathan R Zaccai; Alan Fersht; Gurdyal S Besra; Vincenzo Cerundolo; E Yvonne Jones
The crystal structure of human CD1b with a bound bacterial glycolipid.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2382-8.
2004: Suzanne J Senior; Petr A Illarionov; Sudagar S Gurcha; Ian B Campbell; Merrill L Schaeffer; David E Minnikin; Gurdyal S Besra
Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.
Bioorganic & medicinal chemistry letters 2004;14(2):373-6.
2004: Rosalind A Wilson; William N Maughan; Laurent Kremer; Gurdyal S Besra; Klaus Fütterer
The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases.
Journal of molecular biology 2004;335(2):519-30.
2004: Jin S Im; Karl O A Yu; Petr A Illarionov; Kenneth P LeClair; James R Storey; Malcolm W Kennedy; Gurdyal S Besra; Steven A Porcelli
Direct measurement of antigen binding properties of CD1 proteins using fluorescent lipid probes.
The Journal of biological chemistry 2004;279(1):299-310.
2004: Simon J Waddell; Richard A Stabler; Kenneth Laing; Laurent Kremer; Robert C Reynolds; Gurdyal S Besra
The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds.
Tuberculosis (Edinburgh, Scotland) 2004;84(3-4):263-74.
2004: Geoffrey D Coxon; Juma'a R Al Dulayymi; Caroline Morehouse; Patrick J Brennan; Gurdyal S Besra; Mark S Baird; David E Minnikin
Synthesis and properties of methyl 5-(1'R,2'S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega-19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids.
Chemistry and physics of lipids 2004;127(1):35-46.
2004: Jean Engohang-Ndong; David Baillat; Marc Aumercier; Flore Bellefontaine; Gurdyal S Besra; Camille Locht; Alain Baulard
EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator.
Molecular microbiology 2004;51(1):175-88.
2003: Virginie Molle; Laurent Kremer; Christine Girard-Blanc; Gurdyal S Besra; Alain J Cozzone; Jean-François Prost
An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
Biochemistry 2003;42(51):15300-9.
2003: Benjawan Phetsuksiri; Mary Jackson; Hataichanok Scherman; Michael McNeil; Gurdyal S Besra; Alain Baulard; Richard Slayden; Andrea DeBarber; Clifton E Barry; Mark S Baird; Dean Crick; Patrick J Brennan
Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis.
The Journal of biological chemistry 2003;278(52):53123-30.
2003: Rosalind A Wilson; Sonia Rai; William N Maughan; Laurent Kremer; Benson M Kariuki; Kenneth D M Harris; Trixie Wagner; Gurdyal S Besra; Klaus Fütterer
Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c).
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2303-5.
2003: Ana Cerdeño-Tárraga; Androulla Efstratiou; Lynn Dover; Matthew T G Holden; Mark J Pallen; Stephen Bentley; Gurdyal S Besra; Carol Churcher; Keith D James; Aruni De Zoysa; Tracey Chillingworth; Ann Cronin; L Dowd; Theresa Feltwell; Nancy Hamlin; Simon Holroyd; Kay Jagels; Sharon Moule; Michael A Quail; Ester Rabbinowitsch; Kim Rutherford; Nicholas R Thomson; L Unwin; Sally Whitehead; Bart Barrell; Julian Parkhill
The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129.
Nucleic acids research 2003;31(22):6516-23.
2003: Suzanne J Senior; Petr A Illarionov; Sudagar S Gurcha; Ian B Campbell; Merrill L Schaeffer; David E Minnikin; Gurdyal S Besra
Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.
Bioorganic & medicinal chemistry letters 2003;13(21):3685-8.
2003: Kevin J C Gibson; Lothar Eggeling; William N Maughan; Karin Krumbach; Sudagar S Gurcha; Jerome Nigou; Germain Puzo; Hermann Sahm; Gurdyal S Besra
Disruption of Cg-Ppm1, a polyprenyl monophosphomannose synthase, and the generation of lipoglycan-less mutants in Corynebacterium glutamicum.
The Journal of biological chemistry 2003;278(42):40842-50.
2003: Manuela Cernadas; Masahiko Sugita; Nicole N Van Der Wel; Xiaochun Cao; Jenny E Gumperz; Sergei Maltsev; Gurdyal S Besra; Samuel M Behar; Peter J Peters; Michael B Brenner
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4149-55.
2003: Kevin J C Gibson; Martine GILLERON; Patricia Constant; Germain Puzo; Jerome Nigou; Gurdyal S Besra
Identification of a novel mannose-capped lipoarabinomannan from Amycolatopsis sulphurea.
The Biochemical journal 2003;372(Pt 3):821-9.
2003: Laurent Kremer; Lynn Dover; HECTOR MORBIDONI; Catherine Vilchèze; William N Maughan; Alain Baulard; Shiao-Chun Tu; Nadine Honoré; Vojo Deretic; James C Sacchettini; Camille Locht; William R. Jacobs Jr.; Gurdyal S Besra
Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.
The Journal of biological chemistry 2003;278(23):20547-54.
2003: Kevin J C Gibson; Martine GILLERON; Patricia Constant; Germain Puzo; Jerome Nigou; Gurdyal S Besra
Structural and functional features of Rhodococcus ruber lipoarabinomannan.
Microbiology (Reading, England) 2003;149(Pt 6):1437-45.
2003: Stephen Bentley; Matthias Maiwald; Lee D Murphy; Mark J Pallen; Corin Yeats; Lynn Dover; Halina Norbertczak; Gurdyal S Besra; Michael A Quail; David E Harris; Axel von Herbay; Arlette Goble; Simon Rutter; Robert Squares; Stephen Squares; Bart Barrell; Julian Parkhill; David A Relman
Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei.
Lancet 2003;361(9358):637-44.
2003: Alain Baulard; Sudagar S Gurcha; Jean Engohang-Ndong; Kamila Gouffi; Camille Locht; Gurdyal S Besra
In vivo interaction between the polyprenol phosphate mannose synthase Ppm1 and the integral membrane protein Ppm2 from Mycobacterium smegmatis revealed by a bacterial two-hybrid system.
The Journal of biological chemistry 2003;278(4):2242-8.
2003: Ross F Waller; Stuart A Ralph; Michael B Reed; Vanessa Su; James D Douglas; David E Minnikin; Alan F Cowman; Gurdyal S Besra; Geoffrey I McFadden
A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2003;47(1):297-301.
2002: Ashish K Pathak; Vibha Pathak; Sudagar S Gurcha; Gurdyal S Besra; Robert C Reynolds
Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 2002;12(19):2749-52.
2002: Michelle H. Larsen; Catherine Vilchèze; Laurent Kremer; Gurdyal S Besra; Linda Parsons; Max Salfinger; Leonid Heifets; Manzour H Hazbon; David Alland; James C Sacchettini; William R. Jacobs Jr.
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
Molecular microbiology 2002;46(2):453-66.
2002: Laurent Kremer; Yann Guérardel; Sudagar S Gurcha; Camille Locht; Gurdyal S Besra
Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile.
Microbiology (Reading, England) 2002;148(Pt 10):3145-54.
2002: James D Douglas; Suzanne J Senior; Caroline Morehouse; Benjawan Phetsukiri; Ian B Campbell; Gurdyal S Besra; David E Minnikin
Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity.
Microbiology (Reading, England) 2002;148(Pt 10):3101-9.
2002: Ian C Hancock; Stephen Carman; Gurdyal S Besra; Patrick J Brennan; Emma Waite
Ligation of arabinogalactan to peptidoglycan in the cell wall of Mycobacterium smegmatis requires concomitant synthesis of the two wall polymers.
Microbiology (Reading, England) 2002;148(Pt 10):3059-67.
2002: Kirsty J McLean; Ker R Marshall; Alison Richmond; Iain S Hunter; Kay Fowler; Tobias Kieser; Sudagar S Gurcha; Gurdyal S Besra; Andrew W Munro
Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.
Microbiology (Reading, England) 2002;148(Pt 10):2937-49.
2002: Jerome Nigou; Gurdyal S Besra
Cytidine diphosphate-diacylglycerol synthesis in Mycobacterium smegmatis.
The Biochemical journal 2002;367(Pt 1):157-62.
2002: Yann Guerardel; Emmanuel Maes; Elisabeth Elass; Yves Leroy; Philippe Timmerman; Gurdyal S Besra; Camille Locht; Gérard Strecker; Laurent Kremer
Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with alpha 1,3-mannopyranose side chains.
The Journal of biological chemistry 2002;277(34):30635-48.
2002: Laurent Kremer; Gurdyal S Besra
Current status and future development of antitubercular chemotherapy.
Expert opinion on investigational drugs 2002;11(8):1033-49.
2002: Sudagar S Gurcha; Alain Baulard; Laurent Kremer; Camille Locht; D Branch Moody; Walter Muhlecker; Catherine E Costello; Dean Crick; Patrick J Brennan; Gurdyal S Besra
Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.
The Biochemical journal 2002;365(Pt 2):441-50.
2002: Howard N Cooper; Sudagar S Gurcha; Jerome Nigou; Patrick J Brennan; John Belisle; Gurdyal S Besra; Douglas Young
Characterization of mycobacterial protein glycosyltransferase activity using synthetic peptide acceptors in a cell-free assay.
Glycobiology 2002;12(7):427-34.
2002: Laurent Kremer; Lynn Dover; Séverine Carrère; K Madhavan Nampoothiri; Sarah Lesjean; Alistair K Brown; Patrick J Brennan; David E Minnikin; Camille Locht; Gurdyal S Besra
Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.
The Biochemical journal 2002;364(Pt 2):423-30.
2002: David E Minnikin; Laurent Kremer; Lynn Dover; Gurdyal S Besra
The methyl-branched fortifications of Mycobacterium tuberculosis.
Chemistry & biology 2002;9(5):545-53.
2002: Laurent Kremer; Sudagar S Gurcha; Pablo Bifani; Paul G Hitchen; Alain Baulard; Howard R Morris; Anne Dell; Patrick J Brennan; Gurdyal S Besra
Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.
The Biochemical journal 2002;363(Pt 3):437-47.
2002: D Branch Moody; Volker Briken; Tan-Yun Cheng; Carme Roura-Mir; Mark R Guy; David H Geho; Mark L Tykocinski; Gurdyal S Besra; Steven A Porcelli
Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation.
Nature immunology 2002;3(5):435-42.
2002: Ethan P Grant; Evan M Beckman; Samuel M Behar; Massimo Degano; Daphney Frederique; Gurdyal S Besra; Ian A Wilson; Steven A Porcelli; Stephen T Furlong; Michael B Brenner
Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3933-40.
2002: Jerome Nigou; Lynn Dover; Gurdyal S Besra
Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis.
Biochemistry 2002;41(13):4392-8.
2002: Ashish K Pathak; Vibha Pathak; William J Suling; Sudagar S Gurcha; Caroline B Morehouse; Gurdyal S Besra; Joseph A Maddry; Robert C Reynolds
Studies on n-octyl-5-(alpha-D-arabinofuranosyl)-beta-D-galactofuranosides for mycobacterial glycosyltransferase activity.
Bioorganic & medicinal chemistry 2002;10(4):923-8.
2002: Laurent Kremer; Gurdyal S Besra
Re-emergence of tuberculosis: strategies and treatment.
Expert opinion on investigational drugs 2002;11(2):153-7.
2002: Jerome Nigou; Gurdyal S Besra
Characterization and regulation of inositol monophosphatase activity in Mycobacterium smegmatis.
The Biochemical journal 2002;361(Pt 2):385-90.
2002: Laurent Kremer; William N Maughan; Rosalind A Wilson; Lynn Dover; Gurdyal S Besra
The M. tuberculosis antigen 85 complex and mycolyltransferase activity.
Letters in applied microbiology 2002;34(4):233-7.
2002: Sandra M Newton; Clara Lau; Sudagar S Gurcha; Gurdyal S Besra; Colin W Wright
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.
Journal of ethnopharmacology 2002;79(1):57-67.
2001: Ashish K Pathak; Vibha Pathak; Joseph A Maddry; William J Suling; Sudagar S Gurcha; Gurdyal S Besra; Robert C Reynolds
Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity.
Bioorganic & medicinal chemistry 2001;9(12):3145-51.
2001: Ashish K Pathak; Vibha Pathak; Lainne E Seitz; Joseph A Maddry; Sudagar S Gurcha; Gurdyal S Besra; William J Suling; Robert C Reynolds
Studies on (beta,1-->5) and (beta,1-->6) linked octyl Gal(f) disaccharides as substrates for mycobacterial galactosyltransferase activity.
Bioorganic & medicinal chemistry 2001;9(12):3129-43.
2001: D Branch Moody; Gurdyal S Besra
Glycolipid targets of CD1-mediated T-cell responses.
Immunology 2001;104(3):243-51.
2001: Laurent Kremer; K Madhavan Nampoothiri; Sarah Lesjean; Lynn Dover; S Graham; J Betts; Patrick J Brennan; David E Minnikin; Camille Locht; Gurdyal S Besra
Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.
The Journal of biological chemistry 2001;276(30):27967-74.
2001: Laurent Kremer; Lynn Dover; Caroline Morehouse; P Hitchin; M Everett; Howard R Morris; Anne Dell; Patrick J Brennan; M R McNeil; C Flaherty; K Duncan; Gurdyal S Besra
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase.
The Journal of biological chemistry 2001;276(28):26430-40.
2001: J R Brown; R A Field; A Barker; M Guy; R Grewal; Kay-Hooi Khoo; Patrick J Brennan; Gurdyal S Besra; D Chatterjec
Synthetic mannosides act as acceptors for mycobacterial alpha1-6 mannosyltransferase.
Bioorganic & medicinal chemistry 2001;9(4):815-24.
2000: Katarína Mikusová; Tetsuya Yagi; R Stern; Michael R McNeil; Gurdyal S Besra; Dean Crick; Patrick J Brennan
Biosynthesis of the galactan component of the mycobacterial cell wall.
The Journal of biological chemistry 2000;275(43):33890-7.
2000: D Branch Moody; Mark R Guy; Ethan Grant; Tan-Yun Cheng; Michael B Brenner; Gurdyal S Besra; Steven A Porcelli
CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection.
The Journal of experimental medicine 2000;192(7):965-76.
2000: Dean Crick; Mark C Schulbach; E E Zink; Marco Macchia; Silvia Barontini; Gurdyal S Besra; Patrick J Brennan
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.
Journal of bacteriology 2000;182(20):5771-8.
2000: Alain Baulard; J C Betts; Jean Engohang-Ndong; S Quan; Ruth A McAdam; Patrick J Brennan; Camille Locht; Gurdyal S Besra
Activation of the pro-drug ethionamide is regulated in mycobacteria.
The Journal of biological chemistry 2000;275(36):28326-31.
2000: Laurent Kremer; James D Douglas; Alain Baulard; Caroline Morehouse; M R Guy; DAvid Alland; Lynn Dover; Jeremy H Lakey; William R. Jacobs Jr.; Patrick J Brennan; David E Minnikin; Gurdyal S Besra
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.
The Journal of biological chemistry 2000;275(22):16857-64.
2000: D Branch Moody; T Ulrichs; W Mühlecker; David C Young; Sudagar S Gurcha; Ethan Grant; Jean-Pierre Rosat; Michael B Brenner; Catherine E Costello; Gurdyal S Besra; Steven A Porcelli
CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection.
Nature 2000;404(6780):884-8.
2000: Donald Ronning; Thomas Klabunde; Gurdyal S Besra; Varalakshmi D Vissa; John Belisle; James C Sacchettini
Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.
Nature structural biology 2000;7(2):141-6.
1999: D Branch Moody; Gurdyal S Besra; Ian A Wilson; Steven A Porcelli
The molecular basis of CD1-mediated presentation of lipid antigens.
Immunological reviews 1999;172():285-96.
1999: Ashish K Pathak; Gurdyal S Besra; D Crick; Joseph A Maddry; C B Morehouse; William J Suling; Robert C Reynolds
Studies on beta-D-Gal(f)-(1-->4)-alpha-L-Rha(p) octyl analogues as substrates for mycobacterial galactosyl transferase activity.
Bioorganic & medicinal chemistry 1999;7(11):2407-13.
1999: Merrill L Schaeffer; Kay-Hooi Khoo; Gurdyal S Besra; Delphi Chatterjee; Patrick J Brennan; John Belisle; Julia M Inamine
The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis.
The Journal of biological chemistry 1999;274(44):31625-31.
1999: Benjawan Phetsuksiri; Alain Baulard; A M Cooper; David E Minnikin; James D Douglas; Gurdyal S Besra; Patrick J Brennan
Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis.
Antimicrobial agents and chemotherapy 1999;43(5):1042-51.
1999: D Branch Moody; BB Reinhold; Vernon N Reinhold; Gurdyal S Besra; Steven A Porcelli
Uptake and processing of glycosylated mycolates for presentation to CD1b-restricted T cells.
Immunology letters 1999;65(1-2):85-91.
1998: Ross F Waller; Patrick J Keeling; Robert G K Donald; Boris Striepen; Emanuela Handman; N Lang-Unnasch; Alan F Cowman; Gurdyal S Besra; David S Roos; Geoffrey I McFadden
Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12352-7.
1998: Richard E Lee; Patrick J Brennan; Gurdyal S Besra
Synthesis of beta-D-arabinofuranosyl-1-monophosphoryl polyprenols: examination of their function as mycobacterial arabinosyl transferase donors.
Bioorganic & medicinal chemistry letters 1998;8(8):951-4.
1998: J D Ayers; Todd L Lowary; C B Morehouse; Gurdyal S Besra
Synthetic arabinofuranosyl oligosaccharides as mycobacterial arabinosyltransferase substrates.
Bioorganic & medicinal chemistry letters 1998;8(5):437-42.
1998: Gurdyal S Besra
Preparation of cell-wall fractions from mycobacteria.
Methods in molecular biology (Clifton, N.J.) 1998;101():91-107.
1997: Richard E Lee; Patrick J Brennan; Gurdyal S Besra
Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assay.
Glycobiology 1997;7(8):1121-8.
1997: D Branch Moody; BB Reinhold; Mark R Guy; Evan M Beckman; Daphney Frederique; Stephen T Furlong; S Ye; Vernon N Reinhold; Peter Allan Sieling; Robert L Modlin; Gurdyal S Besra; Steven A Porcelli
Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells.
Science (New York, N.Y.) 1997;278(5336):283-6.
1997: Gurdyal S Besra; Patrick J Brennan
The mycobacterial cell wall: biosynthesis of arabinogalactan and lipoarabinomannan.
Biochemical Society transactions 1997;25(3):845-50.
1997: Gurdyal S Besra; C B Morehouse; C M Rittner; C J Waechter; Patrick J Brennan
Biosynthesis of mycobacterial lipoarabinomannan.
The Journal of biological chemistry 1997;272(29):18460-6.
1997: Richard E Lee; J W Armour; K Takayama; Patrick J Brennan; Gurdyal S Besra
Mycolic acid biosynthesis: definition and targeting of the Claisen condensation step.
Biochimica et biophysica acta 1997;1346(3):275-84.
1997: Yi Xin; Richard E Lee; Michael S Scherman; Kay-Hooi Khoo; Gurdyal S Besra; Patrick J Brennan; Michael McNeil
Characterization of the in vitro synthesized arabinan of mycobacterial cell walls.
Biochimica et biophysica acta 1997;1335(3):231-4.
1997: John Belisle; Varalakshmi D Vissa; T Sievert; K Takayama; Patrick J Brennan; Gurdyal S Besra
Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis.
Science (New York, N.Y.) 1997;276(5317):1420-2.
1997: Patrick J Brennan; Gurdyal S Besra
Structure, function and biogenesis of the mycobacterial cell wall.
Biochemical Society transactions 1997;25(1):188-94.
1997: A Weston; Richard J Stern; Richard E Lee; P M Nassau; D Monsey; S L Martin; Michael S Scherman; Gurdyal S Besra; K Duncan; Michael R McNeil
Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1997;78(2):123-31.
1996: Richard Slayden; Richard E Lee; J W Armour; A M Cooper; Ian M Orme; Patrick J Brennan; Gurdyal S Besra
Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis.
Antimicrobial agents and chemotherapy 1996;40(12):2813-9.
1996: J Liu; C E Barry; Gurdyal S Besra; Hiroshi Nikaido
Mycolic acid structure determines the fluidity of the mycobacterial cell wall.
The Journal of biological chemistry 1996;271(47):29545-51.
1996: Kay-Hooi Khoo; E Douglas; P Azadi; J M Inamine; Gurdyal S Besra; K Mikusová; Patrick J Brennan; Delphi Chatterjee
Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutol.
The Journal of biological chemistry 1996;271(45):28682-90.
1996: AE Belanger; Gurdyal S Besra; Michael E Ford; K Mikusová; John Belisle; Patrick J Brennan; J M Inamine
The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11919-24.
1996: Kay-Hooi Khoo; R Suzuki; Anne Dell; H R Morris; Michael R McNeil; Patrick J Brennan; Gurdyal S Besra
Chemistry of the lyxose-containing mycobacteriophage receptors of Mycobacterium phlei/Mycobacterium smegmatis.
Biochemistry 1996;35(36):11812-9.
1996: K Mikusová; M Mikus; Gurdyal S Besra; I Hancock; Patrick J Brennan
Biosynthesis of the linkage region of the mycobacterial cell wall.
The Journal of biological chemistry 1996;271(13):7820-8.
1996: R E Lee; Patrick J Brennan; Gurdyal S Besra
Mycobacterium tuberculosis cell envelope.
Current topics in microbiology and immunology 1996;215():1-27.
1995: K Mikusová; Richard Slayden; Gurdyal S Besra; Patrick J Brennan
Biogenesis of the mycobacterial cell wall and the site of action of ethambutol.
Antimicrobial agents and chemotherapy 1995;39(11):2484-9.
1995: Kay-Hooi Khoo; R Suzuki; Howard R Morris; Anne Dell; P J Brennan; Gurdyal S Besra
Structural definition of the glycopeptidolipids and the pyruvylated, glycosylated acyltrehalose from Mycobacterium butyricum.
Carbohydrate research 1995;276(2):449-55.
1995: Y Yuan; R E Lee; Gurdyal S Besra; John Belisle; C E Barry
Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6630-4.
1995: Gurdyal S Besra; Kay-Hooi Khoo; Michael R McNeil; Anne Dell; H R Morris; Patrick J Brennan
A new interpretation of the structure of the mycolyl-arabinogalactan complex of Mycobacterium tuberculosis as revealed through characterization of oligoglycosylalditol fragments by fast-atom bombardment mass spectrometry and 1H nuclear magnetic resonance spectroscopy.
Biochemistry 1995;34(13):4257-66.
1994: Gurdyal S Besra; T Sievert; Richard E Lee; Richard Slayden; Patrick J Brennan; K Takayama
Identification of the apparent carrier in mycolic acid synthesis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12735-9.
1994: S Hartmann; Gurdyal S Besra; J L Fraser; W A König; David E Minnikin; Malin Ridell
Stereochemistry of 2,4-dimethyleicos-2-enoate from the pyruvylated glycolipid of Mycobacterium smegmatis.
Biochimica et biophysica acta 1994;1201(3):339-44.
1994: Gurdyal S Besra; S S Gurcha; Kay-Hooi Khoo; H R Morris; Anne Dell; M E Hamid; David E Minnikin; M Goodfellow; Patrick J Brennan
Characterization of the specific antigenicity of representatives of M. senegalense and related bacteria.
Zentralblatt für Bakteriologie : international journal of medical microbiology 1994;281(4):415-32.
1994: Gurdyal S Besra; Kay-Hooi Khoo; John Belisle; Michael R McNeil; H R Morris; Anne Dell; Patrick J Brennan
New pyruvylated, glycosylated acyltrehaloses from Mycobacterium smegmatis strains, and their implications for phage resistance in mycobacteria.
Carbohydrate research 1994;251():99-114.
1993: Gurdyal S Besra; Michael R McNeil; Kay-Hooi Khoo; Anne Dell; H R Morris; Patrick J Brennan
Trehalose-containing lipooligosaccharides of Mycobacterium gordonae: presence of a mono-O-methyltetra-O-acyltrehalose "core" and branching in the oligosaccharide backbone.
Biochemistry 1993;32(47):12705-14.
1993: Gurdyal S Besra; David E Minnikin; P R Wheeler; Colin Ratledge
Synthesis of methyl (Z)-tetracos-5-enoate and both enantiomers of ethyl (E)-6-methyltetracos-4-enoate: possible intermediates in the biosynthesis of mycolic acids in mycobacteria.
Chemistry and physics of lipids 1993;66(1-2):23-34.
1993: P R Wheeler; Gurdyal S Besra; D E Minnikin; Colin Ratledge
Stimulation of mycolic acid biosynthesis by incorporation of cis-tetracos-5-enoic acid in a cell-wall preparation from Mycobacterium smegmatis.
Biochimica et biophysica acta 1993;1167(2):182-8.
1993: Gurdyal S Besra; Michael R McNeil; B Rivoire; Kay-Hooi Khoo; H R Morris; Anne Dell; Patrick J Brennan
Further structural definition of a new family of glycopeptidolipids from Mycobacterium xenopi.
Biochemistry 1993;32(1):347-55.
1993: David E Minnikin; Gurdyal S Besra; R C Bolton; A K Datta; A I Mallet; A Sharif; J L Stanford; Malin Ridell; M Magnusson
Identification of the leprosy bacillus and related mycobacteria by analysis of mycocerosate profiles.
Annales de la Société belge de médecine tropicale 1993;73 Suppl 1():25-34.
1993: David E Minnikin; R C Bolton; S Hartmann; Gurdyal S Besra; P A Jenkins; A I Mallet; E Wilkins; A M Lawson; Malin Ridell
An integrated procedure for the direct detection of characteristic lipids in tuberculosis patients.
Annales de la Société belge de médecine tropicale 1993;73 Suppl 1():13-24.
1992: Gurdyal S Besra; R C Bolton; Michael R McNeil; Malin Ridell; K E Simpson; J Glushka; H van Halbeek; Patrick J Brennan; David E Minnikin
Structural elucidation of a novel family of acyltrehaloses from Mycobacterium tuberculosis.
Biochemistry 1992;31(40):9832-7.
1992: Gurdyal S Besra; Michael R McNeil; Patrick J Brennan
Characterization of the specific antigenicity of Mycobacterium fortuitum.
Biochemistry 1992;31(28):6504-9.
1991: Gurdyal S Besra; Michael McNeil; David E Minnikin; F Portaels; Malin Ridell; Patrick J Brennan
Structural elucidation and antigenicity of a novel phenolic glycolipid antigen from Mycobacterium haemophilum.
Biochemistry 1991;30(31):7772-7.
1990: G Dobson; David E Minnikin; Gurdyal S Besra; A I Mallet; M Magnusson
Characterisation of phenolic glycolipids from Mycobacterium marinum.
Biochimica et biophysica acta 1990;1042(2):176-81.
1990: Gurdyal S Besra; David E Minnikin; A Sharif; J L Stanford
Characteristic new members of the phthiocerol and phenolphthiocerol families from Mycobacterium ulcerans.
FEMS microbiology letters 1990;54(1-3):11-4.
1989: Gurdyal S Besra; David E Minnikin; R C Bolton; A K Datta; A I Mallet; P A Jenkins
Detection of mycobacteria in infected tissue.
Acta leprologica 1989;7 Suppl 1():59-60.
1989: David E Minnikin; Malin Ridell; G Wallerström; Gurdyal S Besra; J H Parlett; R C Bolton; M Magnusson
Comparative studies of antigenic glycolipids of mycobacteria related to the leprosy bacillus.
Acta leprologica 1989;7 Suppl 1():51-4.