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Haydn Pritchard

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Chemicals & Drugs

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Kishor M Wasan; Paul E Goss; P Haydn Pritchard; Lois Shepherd; Dongsheng Tu; James N Ingle
Lipid concentrations in postmenopausal women on letrozole after 5 years of tamoxifen: an NCIC CTG MA.17 sub-study.
Maud N Vissers; Mieke D Trip; P Haydn Pritchard; Patrick Tam; Tatjana Lukic; Monique G M de Sain-Van Der Velden; Martina de Barse; John J P Kastelein
Efficacy and safety of disodium ascorbyl phytostanol phosphates in men with moderate dyslipidemia.
Yana K Reshetnyak; Kissaou T Tchedre; Maya P Nair; P Haydn Pritchard; Andras G Lacko
Structural differences between wild-type and fish eye disease mutant of lecithin:cholesterol acyltransferase.

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2012: Kishor M Wasan; Paul E Goss; P Haydn Pritchard; Lois Shepherd; Dongsheng Tu; James N Ingle
Lipid concentrations in postmenopausal women on letrozole after 5 years of tamoxifen: an NCIC CTG MA.17 sub-study.
Breast cancer research and treatment 2012;136(3):769-76.
2008: Maud N Vissers; Mieke D Trip; P Haydn Pritchard; Patrick Tam; Tatjana Lukic; Monique G M de Sain-Van Der Velden; Martina de Barse; John J P Kastelein
Efficacy and safety of disodium ascorbyl phytostanol phosphates in men with moderate dyslipidemia.
European journal of clinical pharmacology 2008;64(7):651-61.
2006: Yana K Reshetnyak; Kissaou T Tchedre; Maya P Nair; P Haydn Pritchard; Andras G Lacko
Structural differences between wild-type and fish eye disease mutant of lecithin:cholesterol acyltransferase.
Journal of biomolecular structure & dynamics 2006;24(1):75-82.
2004: Daniel van Raalte; Min Li; P Haydn Pritchard; Peter Pritchard
Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future.
Pharmaceutical research 2004;21(9):1531-8.
2004: Agatha W K Ng; Tatjana Lukic; P Haydn Pritchard; Peter Pritchard
Development and characterization of liposomal disodium ascorbyl phytostanyl phosphates (FM-VP4).
Drug development and industrial pharmacy 2004;30(7):739-58.
2003: P Haydn Pritchard; Min Li; Catalina Zamfir; Tatjana Lukic; Egon Novak; Mohammed H Moghadasian
Comparison of cholesterol-lowering efficacy and anti-atherogenic properties of hydrogenated versus non-hydrogenated (Phytrol) tall oil-derived phytosterols in apo E-deficient mice.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2003;17(5-6):443-9.
2003: Tatjana Lukic; Peter Pritchard; Daniela Zamfir; Mohammed H Moghadasian; P Haydn Pritchard
Disodium ascorbyl phytostanyl phosphate reduces plasma cholesterol concentrations and atherosclerotic lesion formation in apolipoprotein E-deficient mice.
Metabolism: clinical and experimental 2003;52(4):425-31.
2003: Peter Pritchard; Catalina Zamfir; P Haydn Pritchard; Raymond A Pederson
Influence of phytostanol phosphoryl ascorbate (FM-VP4) on insulin resistance, hyperglycemia, plasma lipid levels, and gastrointestinal absorption of exogenous cholesterol in Zucker (fa/fa) fatty and lean rats.
Journal of pharmaceutical sciences 2003;92(2):281-8.
2003: Agatha W K Ng; Tatjana Lukic; P Haydn Pritchard; Peter Pritchard
Development of novel water-soluble phytostanol analogs: disodium ascorbyl phytostanyl phosphates (FM-VP4): preclinical pharmacology, pharmacokinetics and toxicology.
Cardiovascular drug reviews 2003;21(3):151-68.
2003: Peter Pritchard; Edwin Yau; Kathy D Boulanger; Manisha Ramswamy; P Haydn Pritchard
Effects of disodium ascorbyl phytostanol phosphates (FM-VP4) on cholesterol accumulation within rat intestinal cells.
AAPS pharmSci 2003;5(1):E6.
2002: Peter Pritchard; Elizabeth M Donnachie; David W Seccombe; P Haydn Pritchard
Effect of cyclosporine A on the binding affinity and internalization of low-density lipoproteins in human skin fibroblasts.
Journal of pharmaceutical sciences 2002;91(12):2520-4.
2002: Scott A Lear; Andrew Ignaszewski; Wolfgang Linden; Anka Brozic; Marla Kiess; John Spinelli; P Haydn Pritchard; Jiri J Frohlich
A randomized controlled trial of an extensive lifestyle management intervention (ELMI) following cardiac rehabilitation: study design and baseline data.
Current controlled trials in cardiovascular medicine 2002;3(1):9.
2002: Manisha Ramaswamy; Edwin Yau; Peter Pritchard; Kathy D Boulanger; Ming Li; P Haydn Pritchard
Influence of phytostanol phosphoryl ascorbate, FM-VP4, on pancreatic lipase activity and cholesterol accumulation within Caco-2 cells.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2002;5(1):29-38.
2001: Scott A Lear; Andrew Ignaszewski; E A Laquer; P Haydn Pritchard; Jiri J Frohlich
Extensive lifestyle management intervention following cardiac rehabilitation: pilot study.
Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses 2001;26(6):227-32.
2001: Peter Pritchard; S Najafi; KD Peteherych; P Haydn Pritchard
Effects of a novel hydrophilic phytostanol analog on plasma lipid concentrations in gerbils.
Journal of pharmaceutical sciences 2001;90(11):1795-9.
2001: Peter Pritchard; S Najafi; J Wong; Mona Kwong; P Haydn Pritchard
Assessing plasma lipid levels, body weight, and hepatic and renal toxicity following chronic oral administration of a water soluble phytostanol compound, FM-VP4, to gerbils.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2001;4(3):228-34.
2001: Peter Pritchard; KD Peteherych; S Najafi; Catalina Zamfir; P Haydn Pritchard
Assessing the plasma pharmacokinetics, tissue distribution, excretion and effects on cholesterol pharmacokinetics of a novel hydrophilic compound, FM-VP4, following administration to rats.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2001;4(3):207-16.
2001: Y Yang; P Haydn Pritchard; J Bhuiyan; David W Seccombe; Mohammed H Moghadasian
Overexpression of acyl-coA binding protein and its effects on the flux of free fatty acids in McA-RH 7777 cells.
Lipids 2001;36(6):595-600.
2001: K R Murray; Maya P Nair; Amir F Ayyobi; John S Hill; P Haydn Pritchard; Andras G Lacko
Probing the 121-136 domain of lecithin:cholesterol acyltransferase using antibodies.
Archives of biochemistry and biophysics 2001;385(2):267-75.
2001: Peter Pritchard; L Holtorf; R Subramanian; SM Cassidy; P Haydn Pritchard; David J Stewart; E Novak; Mohammed H Moghadasian
Assessing plasma pharmacokinetics of cholesterol following oral coadministration with a novel vegetable stanol mixture to fasting rats.
Journal of pharmaceutical sciences 2001;90(1):23-8.
2000: M Li; P Haydn Pritchard
Characterization of the effects of mutations in the putative branchpoint sequence of intron 4 on the splicing within the human lecithin:cholesterol acyltransferase gene.
The Journal of biological chemistry 2000;275(24):18079-84.
2000: Amir F Ayyobi; Andras G Lacko; K Murray; M Nair; M Li; Henri O F Molhuizen; P Haydn Pritchard
Biochemical and compositional analyses of recombinant lecithin:cholesterol acyltransferase (LCAT) obtained from a hepatic source.
Biochimica et biophysica acta 2000;1484(1):1-13.
1999: Peter Pritchard; Ramaswamy Subramanian; J W Chou; Manisha Ramaswamy; P Haydn Pritchard
Cyclosporine transfer from low- and high-density lipoproteins is partially influenced by lipid transfer protein I triglyceride transfer activity.
Pharmaceutical research 1999;16(7):1067-73.
1999: E Choice; Amir F Ayyobi; P Haydn Pritchard; Thomas D Madden
Separation of liposomes from plasma components using fast protein liquid chromatography.
Analytical biochemistry 1999;270(1):1-8.
1998: Peter Pritchard; AL Kennedy; SM Cassidy; Manisha Ramaswamy; L Holtorf; J W Chou; P Haydn Pritchard
Pharmacokinetics, distribution in serum lipoproteins and tissues, and renal toxicities of amphotericin B and amphotericin B lipid complex in a hypercholesterolemic rabbit model: single-dose studies.
Antimicrobial agents and chemotherapy 1998;42(12):3146-52.
1998: Andras G Lacko; A J Reason; C Nuckolls; Bhalchandra J Kudchodkar; Maya P Nair; G Sundarrajan; P Haydn Pritchard; Howard R Morris; Anne Dell
Characterization of recombinant human plasma lecithin: cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties.
Journal of lipid research 1998;39(4):807-20.
1998: M Li; Jan Albert Kuivenhoven; Amir F Ayyobi; P Haydn Pritchard
T-->G or T-->A mutation introduced in the branchpoint consensus sequence of intron 4 of lecithin:cholesterol acyltransferase (LCAT) gene: intron retention causing LCAT deficiency.
Biochimica et biophysica acta 1998;1391(2):256-64.
1998: Peter Pritchard; Manisha Ramaswamy; W Wong; P Haydn Pritchard
Lipid transfer protein I facilitated transfer of cyclosporine from low- to high-density lipoproteins is only partially dependent on its cholesteryl ester transfer activity.
The Journal of pharmacology and experimental therapeutics 1998;284(2):599-605.
1998: W V Rodrigueza; Sandra K Klimuk; P Haydn Pritchard; Michael J Hope
Cholesterol mobilization and regression of atheroma in cholesterol-fed rabbits induced by large unilamellar vesicles.
Biochimica et biophysica acta 1998;1368(2):306-20.
1997: Peter Pritchard; P Haydn Pritchard; Manisha Ramaswamy; W Wong; Elizabeth M Donnachie; L J Brunner
Differences in lipoprotein lipid concentration and composition modify the plasma distribution of cyclosporine.
Pharmaceutical research 1997;14(11):1613-20.
1997: Maya P Nair; Bhalchandra J Kudchodkar; P Haydn Pritchard; Andras G Lacko
Purification of recombinant lecithin: cholesterol acyltransferase.
Protein expression and purification 1997;10(1):38-41.
1997: Jan Albert Kuivenhoven; P de Knijff; JM Boer; H A Smalheer; G J Botma; jacob seidell; John J P Kastelein; P Haydn Pritchard
Heterogeneity at the CETP gene locus. Influence on plasma CETP concentrations and HDL cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(3):560-8.
1997: Mohammed H Moghadasian; B M McManus; P Haydn Pritchard; Jiri J Frohlich
"Tall oil"-derived phytosterols reduce atherosclerosis in ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(1):119-26.
1996: Jan Albert Kuivenhoven; H Weibusch; P Haydn Pritchard; Harald Funke; Rob Benne; G Assmann; John J P Kastelein
An intronic mutation in a lariat branchpoint sequence is a direct cause of an inherited human disorder (fish-eye disease).
The Journal of clinical investigation 1996;98(2):358-64.
1996: Jan Albert Kuivenhoven; A F Stalenhoef; J S Hill; P N Demacker; a Errami; John J P Kastelein; P Haydn Pritchard
Two novel molecular defects in the LCAT gene are associated with fish eye disease.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(2):294-303.
1995: Jan Albert Kuivenhoven; E J van Voorst tot Voorst; H Wiebusch; S M Marcovina; Harald Funke; G Assmann; P Haydn Pritchard; John J P Kastelein
A unique genetic and biochemical presentation of fish-eye disease.
The Journal of clinical investigation 1995;96(6):2783-91.
1995: J Bhuiyan; P Haydn Pritchard; S V Pande; D W Seccombe
Effects of high-fat diet and fasting on levels of acyl-coenzyme A binding protein in liver, kidney, and heart of rat.
Metabolism: clinical and experimental 1995;44(9):1185-9.
1995: Karmin O; J S Hill; P Haydn Pritchard
Role of N-linked glycosylation of lecithin:cholesterol acyltransferase in lipoprotein substrate specificity.
Biochimica et biophysica acta 1995;1254(2):193-7.
1994: J F Bowden; P Haydn Pritchard; J S Hill; Jiri J Frohlich
Lp(a) concentration and apo(a) isoform size. Relation to the presence of coronary artery disease in familial hypercholesterolemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(10):1561-8.
1994: R S McLeod; C Robbins; A Burns; Z Yao; P Haydn Pritchard
Deletion of the propeptide of apolipoprotein A-I impairs exit of nascent apolipoprotein A-I from the endoplasmic reticulum.
The Biochemical journal 1994;302 ( Pt 3)():641-8.
1993: W V Rodrigueza; P Haydn Pritchard; Michael J Hope
The influence of size and composition on the cholesterol mobilizing properties of liposomes in vivo.
Biochimica et biophysica acta 1993;1153(1):9-19.
1993: Karmin O; J S Hill; X Wang; R McLeod; P Haydn Pritchard
Lecithin:cholesterol acyltransferase: role of N-linked glycosylation in enzyme function.
The Biochemical journal 1993;294 ( Pt 3)():879-84.
1993: J S Hill; Karmin O; X Wang; S Paranjape; D Dimitrijevich; Andras G Lacko; P Haydn Pritchard
Expression and characterization of recombinant human lecithin:cholesterol acyltransferase.
Journal of lipid research 1993;34(7):1245-51.
1993: J S Hill; Karmin O; X Wang; P Haydn Pritchard
Lecithin:cholesterol acyltransferase deficiency: identification of a causative gene mutation and a co-inherited protein polymorphism.
Biochimica et biophysica acta 1993;1181(3):321-3.
1993: Karmin O; J S Hill; X Wang; P Haydn Pritchard
Recombinant lecithin:cholesterol acyltransferase containing a Thr123-->Ile mutation esterifies cholesterol in low density lipoprotein but not in high density lipoprotein.
Journal of lipid research 1993;34(1):81-8.
1992: Jiri Frohlich; P Haydn Pritchard
Analysis of familial hypoalphalipoproteinemia syndromes.
Molecular and cellular biochemistry 1992;113(2):141-9.
1992: John J P Kastelein; P Haydn Pritchard; D W Erkelens; Jan Albert Kuivenhoven; J J Albers; J J Frohlich
Familial high-density-lipoprotein deficiency causing corneal opacities (fish eye disease) in a family of Dutch descent.
Journal of internal medicine 1992;231(4):413-9.
1991: J S Hill; Michael R Hayden; J Frohlich; P Haydn Pritchard
Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(2):290-7.
1990: J S Hill; P Haydn Pritchard
Improved phenotyping of apolipoprotein E: application to population frequency distribution.
Clinical chemistry 1990;36(11):1871-4.
1990: L N Peritz; J D Brunzell; C Harvey-Clarke; P Haydn Pritchard; B R Jones; Michael R Hayden
Characterization of a lipoprotein lipase class III type defect in hypertriglyceridemic cats.
Clinical and investigative medicine. Médecine clinique et experimentale 1990;13(5):259-63.
1990: Jiri Frohlich; J Westerlund; D Sparks; P Haydn Pritchard
Familial hypoalphalipoproteinemias.
Clinical and investigative medicine. Médecine clinique et experimentale 1990;13(4):202-10.
1989: Jiri J Frohlich; P Haydn Pritchard
The clinical significance of serum high density lipoproteins.
Clinical biochemistry 1989;22(6):417-23.
1989: D L Sparks; P Haydn Pritchard
Transfer of cholesteryl ester into high density lipoprotein by cholesteryl ester transfer protein: effect of HDL lipid and apoprotein content.
Journal of lipid research 1989;30(10):1491-8.
1989: D L Sparks; P Haydn Pritchard
The neutral lipid composition and size of recombinant high density lipoproteins regulates lecithin:cholesterol acyltransferase activity.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1989;67(7):358-64.
1989: D L Sparks; Jiri Frohlich; Andras G Lacko; P Haydn Pritchard
Relationship between cholesteryl ester transfer activity and high density lipoprotein composition in hyperlipidemic patients.
Atherosclerosis 1989;77(2-3):183-91.
1989: Y I Parmar; D L Sparks; Jiri Frohlich; P R Cullis; P Haydn Pritchard
Detection of vesicular lipoproteins in lecithin:cholesterol acyltransferase-deficient plasma by 1H-NMR spectroscopy.
Journal of lipid research 1989;30(5):765-71.
1989: F G Herring; P S Phillips; P Haydn Pritchard
Proton magnetic resonance spectroscopy of plasma from patients with dyslipoproteinemia: identification of factors governing methyl and methylene proton line widths.
Journal of lipid research 1989;30(4):521-8.
1989: Urs P Steinbrecher; P Haydn Pritchard
Hydrolysis of phosphatidylcholine during LDL oxidation is mediated by platelet-activating factor acetylhydrolase.
Journal of lipid research 1989;30(3):305-15.
1989: Jiri J Frohlich; D W Seccombe; P Haydn Pritchard
The role of apoproteins in disorders of lipoprotein metabolism.
Clinical biochemistry 1989;22(1):51-6.
1988: D L Sparks; Jiri Frohlich; P Haydn Pritchard
Cholesteryl ester transfer activity in plasma of patients with familial high-density lipoprotein deficiency.
Clinical chemistry 1988;34(9):1812-5.
1988: P S Sunga; P Haydn Pritchard; Simon W Rabkin
Effect of cAMP on choline uptake and phosphatidylcholine biosynthesis in cultured chick heart cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1988;66(3):231-7.
1988: P Haydn Pritchard; R McLeod; Jiri Frohlich; M C Park; Bhalchandra J Kudchodkar; Andras G Lacko
Lecithin:cholesterol acyltransferase in familial HDL deficiency (Tangier disease).
Biochimica et biophysica acta 1988;958(2):227-34.
1987: Kim F Wong; Y I Parmar; Lawrence D Mayer; P Haydn Pritchard; Pieter R Cullis
Detection of protein-free lipoprotein analogues with an apolar lipid core by freeze-etch electron microscopy.
Biochimica et biophysica acta 1987;921(2):411-4.
1987: P Haydn Pritchard
The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration.
The Biochemical journal 1987;246(3):791-4.