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Monica Bessler

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

Chemicals & Drugs

Physiology

Living Beings

Mice

Anatomy

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Molecular Sequence Data

Procedures

DNA Mutational Analysis

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Co-Publications
Name
21
Luzzatto, Lucio
17
Mason, Philip
6
Du, Hong-Yan
5
Keller, P
5
Nafa, Khedoudja
5
Kulkarni, Shashikant
4
Rosti, Vittorio
4
Tremml, G
4
Wilson, David
4
Goldman, Frederick
4
Castro-Malaspina, Hugo
3
Gu, Bai-Wei
3
Hillmen, Peter
3
Ivanovich, Jennifer
3
Jasinski, Marek

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Publications

TOP 3
Gu Bai-Wei; Zhao Chunjun; Fan Jian-Meng; Dai Qing; Bessler Monica; Mason Philip J
Anomalous electrophoretic migration of newly synthesized ribosomal RNAs and their precursors from cells with DKC1 mutations.
Nichols Kim E; Bessler Monica
Cancer & inherited bone marrow failure states.
He Jun; Gu Bai-Wei; Ge Jingping; Mochizuki Yuko; Bessler Monica; Mason Philip J
Variable expression of Dkc1 mutations in mice.

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All Publications

2009: Gu Bai-Wei; Zhao Chunjun; Fan Jian-Meng; Dai Qing; Bessler Monica; Mason Philip J
Anomalous electrophoretic migration of newly synthesized ribosomal RNAs and their precursors from cells with DKC1 mutations.
FEBS letters 2009;583(18):3086-90.
2009: Nichols Kim E; Bessler Monica
Cancer & inherited bone marrow failure states.
Blood 2009;113(26):6502-3.
2009: He Jun; Gu Bai-Wei; Ge Jingping; Mochizuki Yuko; Bessler Monica; Mason Philip J
Variable expression of Dkc1 mutations in mice.
Genesis (New York, N.Y. : 2000) 2009;47(6):366-73.
2009: Du Hong-Yan; Mason Philip J; Bessler Monica; Wilson David B
TINF2 mutations in children with severe aplastic anemia.
Pediatric blood & cancer 2009;52(5):687.
2009: Gu BaiWei; Bessler Monica; Mason Philip J
Dyskerin, telomerase and the DNA damage response.
Cell cycle (Georgetown, Tex.) 2009;8(1):6-10.
2009: Du Hong-Yan; Pumbo Elena; Ivanovich Jennifer; An Ping; Maziarz Richard T; Reiss Ulrike M; Chirnomas Deborah; Shimamura Akiko; Vlachos Adrianna; Lipton Jeffrey M; Goyal Rakesh K; Goldman Frederick; Wilson David B; Mason Philip J; Bessler Monica
TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements.
Blood 2009;113(2):309-16.
2008: Robledo Sara; Idol Rachel A; Crimmins Dan L; Ladenson Jack H; Mason Philip J; Bessler Monica
The role of human ribosomal proteins in the maturation of rRNA and ribosome production.
RNA (New York, N.Y.) 2008;14(9):1918-29.
2008: Vlachos Adrianna; Ball Sarah; Dahl Niklas; Alter Blanche P; Sheth Sujit; Ramenghi Ugo; Meerpohl Joerg; Karlsson Stefan; Liu Johnson M; Leblanc Thierry; Paley Carole; Kang Elizabeth M; Leder Eva Judmann; Atsidaftos Eva; Shimamura Akiko; Bessler Monica; Glader Bertil; Lipton Jeffrey M;
Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference.
British journal of haematology 2008;142(6):859-76.
2008: Mason Philip J; Bessler Monica
Dark skin mutations shed light on inherited anemia.
Nature genetics 2008;40(8):931-2.
2008: Gu Bai-Wei; Bessler Monica; Mason Philip J
A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):10173-8.
2008: Brodsky Robert A; Young Neal S; Antonioli Elisabetta; Risitano Antonio M; Schrezenmeier Hubert; Schubert Jörg; Gaya Anna; Coyle Luke; de Castro Carlos; Fu Chieh-Lin; Maciejewski Jaroslaw P; Bessler Monica; Kroon Henk-André; Rother Russell P; Hillmen Peter
Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria.
Blood 2008;111(4):1840-7.
2008: Du Hong-Yan; Pumbo Elena; Manley Peter; Field Joshua J; Bayliss Susan J; Wilson David B; Mason Philip J; Bessler Monica
Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene.
Blood 2008;111(3):1128-30.
2008: Bessler Monica; Hiken Jeffrey
The pathophysiology of disease in patients with paroxysmal nocturnal hemoglobinuria.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2008;():104-10.
2007: Hillmen Peter; Muus Petra; Dührsen Ulrich; Risitano Antonio M; Schubert Jörg; Luzzatto Lucio; Schrezenmeier Hubert; Szer Jeffrey; Brodsky Robert A; Hill Anita; Socié Gerard; Bessler Monica; Rollins Scott A; Bell Leonard; Rother Russell P; Young Neal S
Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria.
Blood 2007;110(12):4123-8.
2007: Du Hong-Yan; Idol Rachel; Robledo Sara; Ivanovich Jennifer; An Ping; Londono-Vallejo Arturo; Wilson David B; Mason Philip J; Bessler Monica
Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome.
Aging cell 2007;6(5):689-97.
2007: Bessler Monica; Du Hong-Yan; Gu Baiwei; Mason Philip J
Dysfunctional telomeres and dyskeratosis congenita.
Haematologica 2007;92(8):1009-12.
2007: Idol Rachel A; Robledo Sara; Du Hong-Yan; Crimmins Dan L; Wilson David B; Ladenson Jack H; Bessler Monica; Mason Philip J
Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production.
Blood cells, molecules & diseases 2007;39(1):35-43.
2006: Huang Quillan; Robledo Sara; Wilson David B; Bessler Monica; Mason Philip J
A four base pair insertion in exon 1 of the RPS19 gene is a common polymorphism in African-Americans.
British journal of haematology 2006;135(5):745-6.
2006: Field Joshua J; Giannone Leonard; Bessler Monica; Blinder Morey A
Immunosuppressive therapy for acute porphyria: safety and efficacy in a patient with bone marrow failure.
Pharmacotherapy 2006;26(11):1662-6.
2006: Field Joshua J; Mason Philip J; An Ping; Kasai Yumi; McLellan Michael; Jaeger Sara; Barnes Yvonne J; King Allison A; Bessler Monica; Wilson David B
Low frequency of telomerase RNA mutations among children with aplastic anemia or myelodysplastic syndrome.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2006;28(7):450-3.
2005: Parker Charles; Omine Mitsuhiro; Richards Stephen; Nishimura Jun-Ichi; Bessler Monica; Ware Russell; Hillmen Peter; Luzzatto Lucio; Young Neal; Kinoshita Taroh; Rosse Wendell; Socié Gerard;
Diagnosis and management of paroxysmal nocturnal hemoglobinuria.
Blood 2005;106(12):3699-709.
2005: Goldman Fred; Bouarich Rachida; Kulkarni Shashikant; Freeman Sara; Du Hong-Yan; Harrington Lea; Mason Philip J; Londoño-Vallejo Arturo; Bessler Monica
The effect of TERC haploinsufficiency on the inheritance of telomere length.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17119-24.
2005: Mason P J; Wilson D B; Bessler M
Dyskeratosis congenita -- a disease of dysfunctional telomere maintenance.
Current molecular medicine 2005;5(2):159-70.
2005: Knudson Matt; Kulkarni Shashikant; Ballas Zuhair K; Bessler Monica; Goldman Frederick
Association of immune abnormalities with telomere shortening in autosomal-dominant dyskeratosis congenita.
Blood 2005;105(2):682-8.
2004: Woloszynek Jill R; Rothbaum Robert J; Rawls Amy S; Minx Patrick J; Wilson Richard K; Mason Philip J; Bessler Monica; Link Daniel C
Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome.
Blood 2004;104(12):3588-90.
2004: Mason Philip J; Bessler Monica
Heterozygous telomerase deficiency in mouse and man: when less is definitely not more.
Cell cycle (Georgetown, Tex.) 2004;3(9):1127-9.
2004: Mochizuki Yuko; He Jun; Kulkarni Shashikant; Bessler Monica; Mason Philip J
Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10756-61.
2004: Jasinski Marek; Pantazopoulos Panagiotis; Rother Russell P; van Rooijen Nico; Song Wen-Chao; Molina Hector; Bessler Monica
A novel mechanism of complement-independent clearance of red cells deficient in glycosyl phosphatidylinositol-linked proteins.
Blood 2004;103(7):2827-34.
2004: Bessler Monica; Wilson David B; Mason Philip J
Dyskeratosis congenita and telomerase.
Current opinion in pediatrics 2004;16(1):23-8.
2004: Spitzer Dirk; Unsinger Jacqueline; Bessler Monica; Atkinson John P
ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement.
Molecular immunology 2004;40(13):911-9.
2004: Han Bing; Unsinger Jacqueline; Liu Fulu; Link Dan C; Bessler Monica
G-CSF induced progenitor mobilization in mice with PIGA- blood cells.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5(4):347-52.
2003: Kulkarni Shashikant; Bessler Monica
Effect of proinflammatory cytokines on PIGA- hematopoiesis.
Experimental hematology 2003;31(9):770-8.
2003: Wilson David B; Ivanovich Jennifer; Whelan Alison; Goodfellow Paul J; Bessler Monica
Human telomerase RNA mutations and bone marrow failure.
Lancet 2003;361(9373):1993-4.
2003: Schaefer Anne; Jasinski Marek; Bessler Monica
High-dose cyclophosphamide does not eradicate paroxysmal nocturnal haemoglobinuria haematopoiesis in mice carrying a Piga gene mutation.
British journal of haematology 2003;120(5):903-6.
2002: Kulkarni Shashikant; Bessler Monica
The effect of GPI-anchor deficiency on apoptosis in mice carrying a Piga gene mutation in hematopoietic cells.
Journal of leukocyte biology 2002;72(6):1228-33.
2002: Keller Peter; Debaun Michael R; Rothbaum Robert J; Bessler Monica
Bone marrow failure in Shwachman-Diamond syndrome does not select for clonal haematopoiesis of the paroxysmal nocturnal haemoglobinuria phenotype.
British journal of haematology 2002;119(3):830-2.
2002: Araten D J; Bessler M; McKenzie S; Castro-Malaspina H; Childs B H; Boulad F; Karadimitris A; Notaro R; Luzzatto L
Dynamics of hematopoiesis in paroxysmal nocturnal hemoglobinuria (PNH): no evidence for intrinsic growth advantage of PNH clones.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(11):2243-8.
2002: He Jun; Navarrete Sandra; Jasinski Murek; Vulliamy Tom; Dokal Inderjeet; Bessler Monica; Mason Philip J
Targeted disruption of Dkc1, the gene mutated in X-linked dyskeratosis congenita, causes embryonic lethality in mice.
Oncogene 2002;21(50):7740-4.
2002: Bessler Monica; Rosti Vittorio; Peng Yufeng; Cattoretti Giorgio; Notaro Rosario; Ohsako Satomi; Elkon Keith B; Luzzatto Lucio
Glycosylphosphatidylinositol-linked proteins are required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.
European journal of immunology 2002;32(9):2607-16.
2001: Araten D J; Swirsky D; Karadimitris A; Notaro R; Nafa K; Bessler M; Thaler H T; Castro-Malaspina H; Childs B H; Boulad F; Weiss M; Anagnostopoulos N; Kutlar A; Savage D G; Maziarz R T; Jhanwar S; Luzzatto L
Cytogenetic and morphological abnormalities in paroxysmal nocturnal haemoglobinuria.
British journal of haematology 2001;115(2):360-8.
2001: Bessler M; Schaefer A; Keller P
Paroxysmal nocturnal hemoglobinuria: insights from recent advances in molecular biology.
Transfusion medicine reviews 2001;15(4):255-67.
2001: Jasinski M; Keller P; Fujiwara Y; Orkin S H; Bessler M
GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells).
Blood 2001;98(7):2248-55.
2001: Vulliamy T; Marrone A; Goldman F; Dearlove A; Bessler M; Mason P J; Dokal I
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita.
Nature 2001;413(6854):432-5.
2001: Keller P; Payne J L; Tremml G; Greer P A; Gaboli M; Pandolfi P P; Bessler M
FES-Cre targets phosphatidylinositol glycan class A (PIGA) inactivation to hematopoietic stem cells in the bone marrow.
The Journal of experimental medicine 2001;194(5):581-9.
1999: Tremml G; Dominguez C; Rosti V; Zhang Z; Pandolfi P P; Keller P; Bessler M
Increased sensitivity to complement and a decreased red blood cell life span in mice mosaic for a nonfunctional Piga gene.
Blood 1999;94(9):2945-54.
1999: Keller P; Tremml G; Rosti V; Bessler M
X inactivation and somatic cell selection rescue female mice carrying a Piga-null mutation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7479-83.
1998: Nafa K; Bessler M; Deeg H J; Luzzatto L
New somatic mutation in the PIG-A gene emerges at relapse of paroxysmal nocturnal hemoglobinuria.
Blood 1998;92(9):3422-7.
1998: Nafa K; Bessler M; Castro-Malaspina H; Jhanwar S; Luzzatto L
The spectrum of somatic mutations in the PIG-A gene in paroxysmal nocturnal hemoglobinuria includes large deletions and small duplications.
Blood cells, molecules & diseases 1998;24(3):370-84.
1998: Bessler M; Hillmen P
Somatic mutation and clonal selection in the pathogenesis and in the control of paroxysmal nocturnal hemoglobinuria.
Seminars in hematology 1998;35(2):149-67.
1997: Rosti V; Tremml G; Soares V; Pandolfi P P; Luzzatto L; Bessler M
Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion.
The Journal of clinical investigation 1997;100(5):1028-36.
1997: Luzzatto L; Bessler M; Rotoli B
Somatic mutations in paroxysmal nocturnal hemoglobinuria: a blessing in disguise?
Cell 1997;88(1):1-4.
1996: Nafa K; Bessler M; Mason P; Vulliamy T; Hillmen P; Castro-Malaspina H; Luzzatto L
Factor V Leiden mutation investigated by amplification created restriction enzyme site (ACRES) in PNH patients with and without thrombosis.
Haematologica 1996;81(6):540-2.
1996: Bessler M
Paroxysmal nocturnal hemoglobinuria: the price for a chance.
Schweizerische medizinische Wochenschrift 1996;126(45):1912-21.
1996: Luzzatto L; Bessler M
The dual pathogenesis of paroxysmal nocturnal hemoglobinuria.
Current opinion in hematology 1996;3(2):101-10.
1995: Nafa K; Mason P J; Hillmen P; Luzzatto L; Bessler M
Mutations in the PIG-A gene causing paroxysmal nocturnal hemoglobinuria are mainly of the frameshift type.
Blood 1995;86(12):4650-5.
1995: Hillmen P; Lewis S M; Bessler M; Luzzatto L; Dacie J V
Natural history of paroxysmal nocturnal hemoglobinuria.
The New England journal of medicine 1995;333(19):1253-8.
1994: Rother R P; Rollins S A; Mennone J; Chodera A; Fidel S A; Bessler M; Hillmen P; Squinto S P
Expression of recombinant transmembrane CD59 in paroxysmal nocturnal hemoglobinuria B cells confers resistance to human complement.
Blood 1994;84(8):2604-11.
1994: Bessler M; Mason P J; Hillmen P; Luzzatto L
Mutations in the PIG-A gene causing partial deficiency of GPI-linked surface proteins (PNH II) in patients with paroxysmal nocturnal haemoglobinuria.
British journal of haematology 1994;87(4):863-6.
1994: Longo L; Bessler M; Beris P; Swirsky D; Luzzatto L
Myelodysplasia in a patient with pre-existing paroxysmal nocturnal haemoglobinuria: a clonal disease originating from within a clonal disease.
British journal of haematology 1994;87(2):401-3.
1994: Bessler M; Hillmen P; Longo L; Luzzatto L; Mason P J
Genomic organization of the X-linked gene (PIG-A) that is mutated in paroxysmal nocturnal haemoglobinuria and of a related autosomal pseudogene mapped to 12q21.
Human molecular genetics 1994;3(5):751-7.
1994: Bessler M; Mason P; Hillmen P; Luzzatto L
Somatic mutations and cellular selection in paroxysmal nocturnal haemoglobinuria.
Lancet 1994;343(8903):951-3.
1994: Bessler M; Mason P J; Hillmen P; Miyata T; Yamada N; Takeda J; Luzzatto L; Kinoshita T
Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene.
The EMBO journal 1994;13(1):110-7.
1993: Hillmen P; Bessler M; Mason P J; Watkins W M; Luzzatto L
Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5272-6.
1993: Rotoli B; Bessler M; Alfinito F; del Vecchio L
Membrane proteins in paroxysmal nocturnal haemoglobinuria.
Blood reviews 1993;7(2):75-86.
1993: Hillmen P; Bessler M; Bungey J; Luzzatto L
Paroxysmal nocturnal hemoglobinuria: correction of abnormal phenotype by somatic cell hybridization.
Somatic cell and molecular genetics 1993;19(2):123-9.
1993: Hillmen P; Bessler M; Crawford D H; Luzzatto L
Production and characterization of lymphoblastoid cell lines with the paroxysmal nocturnal hemoglobinuria phenotype.
Blood 1993;81(1):193-9.
1992: Bessler M; Hillmen P; Luzzatto L
Clonal origin of abnormal granulocytes in paroxysmal nocturnal hemoglobinuria.
Blood 1992;80(3):844-5.
1991: Bessler M; Fehr J
Fc III receptors (FcRIII) on granulocytes: a specific and sensitive diagnostic test for paroxysmal nocturnal hemoglobinuria (PNH).
European journal of haematology 1991;47(3):179-84.

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