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Edward Prochownik

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Jeremy L Yap; Jay Chauhan; Robert B Gharavi; Angela Hu; Kwan-Young Jung; Edward V Prochownik; Huabo Wang; Stephen Fletcher
Pharmacophore identification of c-Myc inhibitor 10074-G5.
Fang Zhang; Sajithlal B Gangadharan; Yves Pommier; Edward V Prochownik; Kristi Rothermund; John S Lazo
Phenotypic screening reveals topoisomerase I as a breast cancer stem cell therapeutic target.
Seog-Young Kim; Edward V Prochownik; Juong G Rhee; Xinxin Song; Douglas R Spitz; Yong J Lee
Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM.

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All Publications

2013: Jeremy L Yap; Jay Chauhan; Robert B Gharavi; Angela Hu; Kwan-Young Jung; Edward V Prochownik; Huabo Wang; Stephen Fletcher
Pharmacophore identification of c-Myc inhibitor 10074-G5.
Bioorganic & medicinal chemistry letters 2013;23(1):370-4.
2012: Fang Zhang; Sajithlal B Gangadharan; Yves Pommier; Edward V Prochownik; Kristi Rothermund; John S Lazo
Phenotypic screening reveals topoisomerase I as a breast cancer stem cell therapeutic target.
Oncotarget 2012;3(9):998-1010.
2012: Seog-Young Kim; Edward V Prochownik; Juong G Rhee; Xinxin Song; Douglas R Spitz; Yong J Lee
Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM.
PloS one 2012;7(11):e50423.
2012: J Anthony Graves; Donna Beer-Stolz; Maria F Branca; Edward Cherok; Jennifer D Elster; Kristi Rothermund; Sunder Sims-Lucas; Bennett Van Houten; Jerry Vockley; Yudong Wang; Edward V Prochownik
Mitochondrial structure, function and dynamics are temporally controlled by c-Myc.
PloS one 2012;7(5):e37699.
2012: Terence F McGuire; Robert D Nicholls; Jie Lu; Gangadharan B Sajithlal; Edward V Prochownik
In vivo evolution of tumor-derived endothelial cells.
PloS one 2012;7(5):e37138.
2010: Dana M Clausen; Jianxia Guo; Robert A Parise; Jan H Beumer; Merrill J Egorin; John Lazo; Edward V Prochownik; Julie L Eiseman
In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization.
The Journal of pharmacology and experimental therapeutics 2010;335(3):715-27.
2010: Gangadharan B Sajithlal; Terence F McGuire; Jie Lu; Donna Beer-Stolz; Edward V Prochownik
Endothelial-like cells derived directly from human tumor xenografts.
International journal of cancer. Journal international du cancer 2010;127(10):2268-78.
2010: Gangadharan B Sajithlal; Kristi Rothermund; Fang Zhang; David J Dabbs; Jean J Latimer; Stephen G Grant; Edward V Prochownik
Permanently blocked stem cells derived from breast cancer cell lines.
Stem cells (Dayton, Ohio) 2010;28(6):1008-18.
2010: Pili Zhang; Mallikarjurna R Metukuri; Sharell M Bindom; Edward V Prochownik; Robert M O'Doherty; Donald Scott
c-Myc is required for the CHREBP-dependent activation of glucose-responsive genes.
Molecular endocrinology (Baltimore, Md.) 2010;24(6):1274-86.
2010: Youjun Li; Fengfeng L Xu; Jie Lu; William S Saunders; Edward V Prochownik
Widespread genomic instability mediated by a pathway involving glycoprotein Ib alpha and Aurora B kinase.
The Journal of biological chemistry 2010;285(17):13183-92.
2010: J Anthony Graves; Kristi Rothermund; Tao Wang; Wei Qian; Bennett Van Houten; Edward V Prochownik
Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts.
PloS one 2010;5(10):e13717.
2010: Qian Wu; Fengfeng L Xu; Youjun Li; Edward V Prochownik; William S Saunders
The c-Myc target glycoprotein1balpha links cytokinesis failure to oncogenic signal transduction pathways in cultured human cells.
PloS one 2010;5(5):e10819.
2009: Dalia I Hammoudeh; Ariele Viacava Follis; Edward V Prochownik; Steven J Metallo
Multiple independent binding sites for small-molecule inhibitors on the oncoprotein c-Myc.
Journal of the American Chemical Society 2009;131(21):7390-401.
2009: Gabriela Mustata; Ariele Viacava Follis; Dalia I Hammoudeh; Steven J Metallo; Huabo Wang; Edward V Prochownik; John Lazo; Ivet Bahar
Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model.
Journal of medicinal chemistry 2009;52(5):1247-50.
2009: J Anthony Graves; Mallikarjuna Metukuri; Donald Scott; Kristi Rothermund; Edward V Prochownik
Regulation of reactive oxygen species homeostasis by peroxiredoxins and c-Myc.
The Journal of biological chemistry 2009;284(10):6520-9.
2009: Jianxia Guo; Robert A Parise; Erin Joseph; Merrill J Egorin; John Lazo; Edward V Prochownik; Julie L Eiseman
Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice.
Cancer chemotherapy and pharmacology 2009;63(4):615-25.
2009: Youjun Li; Jie Lu; Edward V Prochownik
Modularity of the oncoprotein-like properties of platelet glycoprotein Ibalpha.
The Journal of biological chemistry 2009;284(3):1410-8.
2008: Ariele Viacava Follis; Dalia I Hammoudeh; Huabo Wang; Edward V Prochownik; Steven J Metallo
Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules.
Chemistry & biology 2008;15(11):1149-55.
2008: Edward V Prochownik
c-Myc: linking transformation and genomic instability.
Current molecular medicine 2008;8(6):446-58.
2008: H Wang; S Mannava; V Grachtchouk; D Zhuang; Maria Soengas; A V Gudkov; Edward V Prochownik; Mikhail Nikiforov
c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle.
Oncogene 2008;27(13):1905-15.
2008: Youjun Li; J Lu; D Cohen; Edward V Prochownik
Transformation, genomic instability and senescence mediated by platelet/megakaryocyte glycoprotein Ibalpha.
Oncogene 2008;27(11):1599-609.
2007: Huabo Wang; Dalia I Hammoudeh; Ariele Viacava Follis; Brian E Reese; John Lazo; Steven J Metallo; Edward V Prochownik
Improved low molecular weight Myc-Max inhibitors.
Molecular cancer therapeutics 2007;6(9):2399-408.
2007: Youjun Li; Jie Lu; Edward V Prochownik
Dual role for SUMO E2 conjugase Ubc9 in modulating the transforming and growth-promoting properties of the HMGA1b architectural transcription factor.
The Journal of biological chemistry 2007;282(18):13363-71.
2007: Edward V Prochownik; Youjun Li
The ever expanding role for c-Myc in promoting genomic instability.
Cell cycle (Georgetown, Tex.) 2007;6(9):1024-9.
2007: Youjun Li; Jie Lu; Edward V Prochownik
c-Myc-mediated genomic instability proceeds via a megakaryocytic endomitosis pathway involving Gp1balpha.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3490-5.
2006: Youjun Li; Kenneth Rogulski; Quansheng Zhou; Peter J Sims; Edward V Prochownik
The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1.
Molecular and cellular biology 2006;26(9):3401-13.
2006: Debra E Cohen; Edward V Prochownik
A functional hierarchy for c-Myc target genes? Lessons from MT-MC1.
Cell cycle (Georgetown, Tex.) 2006;5(4):392-3.
2005: Kenneth Rogulski; Debra E Cohen; David L Corcoran; Panayiotis V Benos; Edward V Prochownik
Deregulation of common genes by c-Myc and its direct target, MT-MC1.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):18968-73.
2005: Rachel A Egler; Elaine Fernandes; Kristi Rothermund; Susan M Sereika; Nadja C de Souza-Pinto; Pawel Jaruga; Miral Dizdaroglu; Edward V Prochownik
Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1.
Oncogene 2005;24(54):8038-50.
2005: Kenneth Rogulski; Youjun Li; Kristi Rothermund; Lixia Pu; simon simon watkins; Fenghua Yi; Edward V Prochownik
Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway.
Oncogene 2005;24(51):7524-41.
2005: Edward V Prochownik
Functional and physical communication between oncoproteins and tumor suppressors.
Cellular and molecular life sciences : CMLS 2005;62(21):2438-59.
2005: Kristi Rothermund; Kenneth Rogulski; Elaine Fernandes; Amy Whiting; John Sedivy; Lixia Pu; Edward V Prochownik
C-Myc-independent restoration of multiple phenotypes by two C-Myc target genes with overlapping functions.
Cancer research 2005;65(6):2097-107.
2004: Uma Kamasani; Minzhou Huang; James B DuHadaway; Edward V Prochownik; preston scott donover; George C Prendergast
Cyclin B1 is a critical target of RhoB in the cell suicide program triggered by farnesyl transferase inhibition.
Cancer research 2004;64(22):8389-96.
2004: Edward V Prochownik
c-Myc as a therapeutic target in cancer.
Expert review of anticancer therapy 2004;4(2):289-302.
2003: Xiaoying Yin; Christine Giap; John Lazo; Edward V Prochownik
Low molecular weight inhibitors of Myc-Max interaction and function.
Oncogene 2003;22(40):6151-9.
2003: Fenghua Yi; Ronald Jaffe; Edward V Prochownik
The CCL6 chemokine is differentially regulated by c-Myc and L-Myc, and promotes tumorigenesis and metastasis.
Cancer research 2003;63(11):2923-32.
2002: Zhao Mei Mu; Xiaoying Yin; Edward V Prochownik
Pag, a putative tumor suppressor, interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expression.
The Journal of biological chemistry 2002;277(45):43175-84.
2002: Xiaoying Yin; Linnette Grove; Kenneth Rogulski; Edward V Prochownik
Myc target in myeloid cells-1, a novel c-Myc target, recapitulates multiple c-Myc phenotypes.
The Journal of biological chemistry 2002;277(22):19998-20010.
2001: Xiaoying Yin; Linnette Grove; Nabanita S Datta; K Katula; Michael W Long; Edward V Prochownik
Inverse regulation of cyclin B1 by c-Myc and p53 and induction of tetraploidy by cyclin B1 overexpression.
Cancer research 2001;61(17):6487-93.
2001: Xiaoying Yin; M F Landay; W Han; E S Levitan; simon simon watkins; Richard Levenson; Daniel L Farkas; Edward V Prochownik
Dynamic in vivo interactions among Myc network members.
Oncogene 2001;20(34):4650-64.
2001: Xiaoying Yin; Linnette Grove; Edward V Prochownik
Mmip-2/Rnf-17 enhances c-Myc function and regulates some target genes in common with glucocorticoid hormones.
Oncogene 2001;20(23):2908-17.
2000: M Landay; Sara K Oster; Fereshteh Khosravi; Linnette Grove; Xiaoying Yin; J Sedivy; L Z Penn; Edward V Prochownik
Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family.
Cell death and differentiation 2000;7(8):697-705.
2000: CE Nesbit; J M Tersak; Linnette Grove; A Drzal; H Choi; Edward V Prochownik
Genetic dissection of c-myc apoptotic pathways.
Oncogene 2000;19(28):3200-12.
1999: Xiaoying Yin; K Gupta; W P Han; E S Levitan; Edward V Prochownik
Mmip-2, a novel RING finger protein that interacts with mad members of the Myc oncoprotein network.
Oncogene 1999;18(48):6621-34.
1999: K Elliott; Daitoku Sakamuro; A Basu; Wei Du; William H Wunner; P Staller; Stefan Gaubatz; H Zhang; Edward V Prochownik; Martin Eilers; George C Prendergast
Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms.
Oncogene 1999;18(24):3564-73.
1999: CE Nesbit; J M Tersak; Edward V Prochownik
MYC oncogenes and human neoplastic disease.
Oncogene 1999;18(19):3004-16.
1999: Xiaoying Yin; Linnette Grove; Nabanita S Datta; Michael W Long; Edward V Prochownik
C-myc overexpression and p53 loss cooperate to promote genomic instability.
Oncogene 1999;18(5):1177-84.
1998: CE Nesbit; Linnette Grove; Xiaoying Yin; Edward V Prochownik
Differential apoptotic behaviors of c-myc, N-myc, and L-myc oncoproteins.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(9):731-41.
1998: CE Nesbit; S Fan; H Zhang; Edward V Prochownik
Distinct apoptotic responses imparted by c-myc and max.
Blood 1998;92(3):1003-10.
1998: Edward V Prochownik; L Eagle Grove; DA Deubler; X L Zhu; Robert A Stephenson; L Ralph Rohr; Xiaoying Yin; Arthur R Brothman
Commonly occurring loss and mutation of the MXI1 gene in prostate cancer.
Genes, chromosomes & cancer 1998;22(4):295-304.
1998: Xiaoying Yin; Linnette Grove; Edward V Prochownik
Lack of transcriptional repression by max homodimers.
Oncogene 1998;16(20):2629-37.
1998: K Gupta; G Anand; Xiaoying Yin; Linnette Grove; Edward V Prochownik
Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc.
Oncogene 1998;16(9):1149-59.
1997: K Langlands; Xiaoying Yin; G Anand; Edward V Prochownik
Differential interactions of Id proteins with basic-helix-loop-helix transcription factors.
The Journal of biological chemistry 1997;272(32):19785-93.
1997: G Anand; Xiaoying Yin; A K Shahidi; Linnette Grove; Edward V Prochownik
Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome.
The Journal of biological chemistry 1997;272(31):19140-51.
1997: K Langlands; Edward V Prochownik
A rapid method for the preparation of yeast lysates that facilitates the immunodetection of proteins generated by the yeast two-hybrid system.
Analytical biochemistry 1997;249(2):250-2.
1995: C L Yu; Edward V Prochownik; Richard Jove
Proximal promoter region of the junB gene mediates attenuation of serum inducibility in Src-transformed cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(12):1513-21.
1995: L R Eagle; Xiaoying Yin; Arthur R Brothman; B J Williams; N B Atkin; Edward V Prochownik
Mutation of the MXI1 gene in prostate cancer.
Nature genetics 1995;9(3):249-55.
1994: D K Shumaker; M D Sklar; Edward V Prochownik; James Varani
Increased cell-substrate adhesion accompanies conditional reversion to the normal phenotype in ras-oncogene-transformed NIH-3T3 cells.
Experimental cell research 1994;214(2):440-6.
1994: DN Shapiro; Virginia Valentine; L Eagle; Xiaoying Yin; Stephan W Morris; Edward V Prochownik
Assignment of the human MAD and MXI1 genes to chromosomes 2p12-p13 and 10q24-q25.
Genomics 1994;23(1):282-5.
1994: J J Ryan; Edward V Prochownik; C A Gottlieb; Ingrid J Apel; Ramón Merino; Gabriel Nuñez; Michael F Clarke
c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):5878-82.
1994: G Anand; DN Shapiro; P S Dickman; Edward V Prochownik
Rhabdomyosarcomas do not contain mutations in the DNA binding domains of myogenic transcription factors.
The Journal of clinical investigation 1994;93(1):5-9.
1993: C L Yu; Edward V Prochownik; Michael J Imperiale; Richard Jove
Attenuation of serum inducibility of immediate early genes by oncoproteins in tyrosine kinase signaling pathways.
Molecular and cellular biology 1993;13(4):2011-9.
1993: Edward V Prochownik; M E VanAntwerp
Differential patterns of DNA binding by myc and max proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(3):960-4.
1992: M E Van Antwerp; D G Chen; C Chang; Edward V Prochownik
A point mutation in the MyoD basic domain imparts c-Myc-like properties.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9010-4.
1992: Ingrid J Apel; C L Yu; T Wang; C Dobry; M E Van Antwerp; Richard Jove; Edward V Prochownik
Regulation of the junB gene by v-src.
Molecular and cellular biology 1992;12(8):3356-64.
1992: M J Smith; Edward V Prochownik
Inhibition of c-jun causes reversible proliferative arrest and withdrawal from the cell cycle.
Blood 1992;79(8):2107-15.
1991: M D Sklar; E Thompson; Michael J Welsh; Monica Liebert; J Harney; H B Grossman; M Smith; Edward V Prochownik
Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells.
Molecular and cellular biology 1991;11(7):3699-710.
1991: Valerie P Castle; James Varani; S Fligiel; Edward V Prochownik; V Dixit
Antisense-mediated reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma.
The Journal of clinical investigation 1991;87(6):1883-8.
1991: M D Sklar; Edward V Prochownik
Modulation of cis-platinum resistance in Friend erythroleukemia cells by c-myc.
Cancer research 1991;51(8):2118-23.
1990: M G Caty; Keith T Oldham; Edward V Prochownik
Embryonal rhabdomyosarcoma of the ampulla of Vater with long-term survival following pancreaticoduodenectomy.
Journal of pediatric surgery 1990;25(12):1256-8.
1990: Edward V Prochownik; M J Smith; K Snyder; D Emeagwali
Amplified expression of three jun family members inhibits erythroleukemia differentiation.
Blood 1990;76(9):1830-7.
1990: M J Smith; D C Charron-Prochownik; Edward V Prochownik
The leucine zipper of c-Myc is required for full inhibition of erythroleukemia differentiation.
Molecular and cellular biology 1990;10(10):5333-9.
1990: Michael W Long; C H Heffner; J L Williams; C Peters; Edward V Prochownik
Regulation of megakaryocyte phenotype in human erythroleukemia cells.
The Journal of clinical investigation 1990;85(4):1072-84.
1990: Xiaodong Huang; S Green; J Vidya Sarma; Lawrence B Holzman; F W Wolf; K O'Rourke; Peter A Ward; Edward V Prochownik; Rory M Marks
Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.
The Journal of biological chemistry 1990;265(5):2973-8.
1989: Xiaodong Huang; Rory M Marks; J Vidya Sarma; Edward V Prochownik
The antimitogenic action of tumor necrosis factor is associated with increased AP-1/c-jun proto-oncogene transcription.
The Journal of biological chemistry 1989;264(28):16905-9.
1989: Edward V Prochownik; K O'Rourke; Xiaodong Huang
Expression and analysis of COOH-terminal deletions of the human thrombospondin molecule.
The Journal of cell biology 1989;109(2):843-52.
1989: Edward V Prochownik
c-myb but not c-myc suppresses the hemin-induced nonterminal expression of hemoglobin by murine erythroleukemia cells.
Blood 1989;73(3):782-6.
1989: Edward V Prochownik
Protooncogenes and cell differentiation.
Transfusion medicine reviews 1989;3(1):24-38.
1988: Edward V Prochownik; Jolanta F Kukowska-Latallo; C Rodgers
c-myc antisense transcripts accelerate differentiation and inhibit G1 progression in murine erythroleukemia cells.
Molecular and cellular biology 1988;8(9):3683-95.
1988: Michael F Clarke; Jolanta F Kukowska-Latallo; E Westin; M Smith; Edward V Prochownik
Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation.
Molecular and cellular biology 1988;8(2):884-92.
1986: Edward V Prochownik; Jolanta F Kukowska-Latallo
Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiation.
Nature 1986;322(6082):848-50.