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Darwin Prockop

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Molecular Sequence Data

Physiology

Disorders

Osteogenesis Imperfecta

Anatomy

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Mice

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Polymerase Chain Reaction

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Co-Publications
Name
37
Ala-Kokko, Leena
31
Tromp, Gerard
30
Kuivaniemi, Helena
15
Fertala, Andrzej
14
Pochampally, Radhika
13
Khillan, Jaspal Singh
12
Kadler, Karl
12
Gregory, Carl
12
Spees, Jeffrey
12
Phinney , Donald
11
Sieron, Aleksander
9
Körkkö, Jarmo
8
Helminen, Heikki
8
Larson, Benjamin
8
Peister, Alexandra

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Publications

TOP 3
Barrilleaux Bonnie L; Phinney Donald G; Fischer-Valuck Benjamin W; Russell Katie C; Wang Guoshun; Prockop Darwin J; O'Connor Kim C
Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells.
Lee Ryang Hwa; Pulin Andrey A; Seo Min Jeong; Kota Daniel J; Ylostalo Joni; Larson Benjamin L; Semprun-Prieto Laura; Delafontaine Patrice; Prockop Darwin J
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6.
Belmadani Souad; Matrougui Khalid; Kolz Chris; Pung Yuh Fen; Palen Desiree; Prockop Darwin J; Chilian William M
Amplification of coronary arteriogenic capacity of multipotent stromal cells by epidermal growth factor.

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All Publications

2009: Barrilleaux Bonnie L; Phinney Donald G; Fischer-Valuck Benjamin W; Russell Katie C; Wang Guoshun; Prockop Darwin J; O'Connor Kim C
Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells.
Tissue engineering. Part A 2009;15(9):2335-46.
2009: Lee Ryang Hwa; Pulin Andrey A; Seo Min Jeong; Kota Daniel J; Ylostalo Joni; Larson Benjamin L; Semprun-Prieto Laura; Delafontaine Patrice; Prockop Darwin J
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6.
Cell stem cell 2009;5(1):54-63.
2009: Belmadani Souad; Matrougui Khalid; Kolz Chris; Pung Yuh Fen; Palen Desiree; Prockop Darwin J; Chilian William M
Amplification of coronary arteriogenic capacity of multipotent stromal cells by epidermal growth factor.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(6):802-8.
2009: Prockop Darwin J
Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(6):939-46.
2009: Block Gregory J; Ohkouchi Shinya; Fung France; Frenkel Joshua; Gregory Carl; Pochampally Radhika; DiMattia Gabriel; Sullivan Deborah E; Prockop Darwin J
Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1.
Stem cells (Dayton, Ohio) 2009;27(3):670-81.
2009: Lee Ryang Hwa; Seo Min Jeong; Pulin Andrey A; Gregory Carl A; Ylostalo Joni; Prockop Darwin J
The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice.
Blood 2009;113(4):816-26.
2008: Oskowitz Adam Z; Lu Jun; Penfornis Patrice; Ylostalo Joni; McBride Jane; Flemington Erik K; Prockop Darwin J; Pochampally Radhika
Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18372-7.
2008: Ylöstalo Joni; Bazhanov Nikolay; Prockop Darwin J
Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies.
Experimental hematology 2008;36(10):1390-402.
2008: Ohtaki Hirokazu; Ylostalo Joni H; Foraker Jessica E; Robinson Andrew P; Reger Roxanne L; Shioda Seiji; Prockop Darwin J
Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14638-43.
2008: Weiss Daniel J; Kolls Jay K; Ortiz Luis A; Panoskaltsis-Mortari Angela; Prockop Darwin J
Stem cells and cell therapies in lung biology and lung diseases.
Proceedings of the American Thoracic Society 2008;5(5):637-67.
2008: Spees Jeffrey L; Whitney Mandolin J; Sullivan Deborah E; Lasky Joseph A; Laboy Miguel; Ylostalo Joni; Prockop Darwin J
Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(4):1226-36.
2008: Larson Benjamin L; Ylöstalo Joni; Prockop Darwin J
Human multipotent stromal cells undergo sharp transition from division to development in culture.
Stem cells (Dayton, Ohio) 2008;26(1):193-201.
2008: Zeitouni Suzanne; Ford Brian S; Harris Sean M; Whitney Mandolin J; Gregory Carl A; Prockop Darwin J
Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs).
BMC biotechnology 2008;8():75.
2008: Prockop Darwin J; Phinney Donald G; Bunnell Bruce A
Methods and protocols. Preface.
Methods in molecular biology (Clifton, N.J.) 2008;449():v-vii.
2008: Ylöstalo Joni; Pochampally Radhika; Prockop Darwin J
Assays of MSCs with microarrays.
Methods in molecular biology (Clifton, N.J.) 2008;449():133-51.
2007: Lee N; Smolarz A J; Olson S; David O; Reiser J; Kutner R; Daw N C; Prockop D J; Horwitz E M; Gregory C A
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies.
British journal of cancer 2007;97(11):1552-9.
2007: Kesteloot Frédéric; Desmoulière Alexis; Leclercq Isabelle; Thiry Marc; Arrese Jorge E; Prockop Darwin J; Lapière Charles M; Nusgens Betty V; Colige Alain
ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice.
Hepatology (Baltimore, Md.) 2007;46(5):1620-31.
2007: Phinney Donald G; Prockop Darwin J
Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views.
Stem cells (Dayton, Ohio) 2007;25(11):2896-902.
2007: Prockop D J
"Stemness" does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs).
Clinical pharmacology and therapeutics 2007;82(3):241-3.
2007: Pochampally Radhika R; Ylostalo Joni; Penfornis Patrice; Matz Robert R; Smith Jason R; Prockop Darwin J
Histamine receptor H1 and dermatopontin: new downstream targets of the vitamin D receptor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(9):1338-49.
2007: Hung Shih-Chieh; Pochampally Radhika R; Chen Sy-Chi; Hsu Shu-Ching; Prockop Darwin J
Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis.
Stem cells (Dayton, Ohio) 2007;25(9):2363-70.
2007: Spees Jeffrey L; Pociask Derek A; Sullivan Deborah E; Whitney Mandolin J; Lasky Joseph A; Prockop Darwin J; Brody Arnold R
Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis.
American journal of respiratory and critical care medicine 2007;176(4):385-94.
2007: Prockop Darwin J; Olson Scott D
Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions.
Blood 2007;109(8):3147-51.
2007: Iso Yoshitaka; Spees Jeffrey L; Serrano Claudia; Bakondi Benjamin; Pochampally Radhika; Song Yao-Hua; Sobel Burton E; Delafontaine Patrick; Prockop Darwin J
Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment.
Biochemical and biophysical research communications 2007;354(3):700-6.
2007: Marini Joan C; Forlino Antonella; Cabral Wayne A; Barnes Aileen M; San Antonio James D; Milgrom Sarah; Hyland James C; Körkkö Jarmo; Prockop Darwin J; De Paepe Anne; Coucke Paul; Symoens Sofie; Glorieux Francis H; Roughley Peter J; Lund Alan M; Kuurila-Svahn Kaija; Hartikka Heini; Cohn Daniel H; Krakow Deborah; Mottes Monica; Schwarze Ulrike; Chen Diana; Yang Kathleen; Kuslich Christine; Troendle James; Dalgleish Raymond; Byers Peter H
Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans.
Human mutation 2007;28(3):209-21.
2007: Tolar Jakub; Nauta Alma J; Osborn Mark J; Panoskaltsis Mortari Angela; McElmurry Ron T; Bell Scott; Xia Lily; Zhou Ning; Riddle Megan; Schroeder Tania M; Westendorf Jennifer J; McIvor R Scott; Hogendoorn Pancras C W; Szuhai Karoly; Oseth Leann; Hirsch Betsy; Yant Stephen R; Kay Mark A; Peister Alexandra; Prockop Darwin J; Fibbe Willem E; Blazar Bruce R
Sarcoma derived from cultured mesenchymal stem cells.
Stem cells (Dayton, Ohio) 2007;25(2):371-9.
2007: Hung Shih-Chieh; Pochampally Radhika R; Hsu Shu-Ching; Sanchez Cecelia; Chen Sy-Chi; Spees Jeffrey; Prockop Darwin J
Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo.
PloS one 2007;2(5):e416.
2006: Barrilleaux Bonnie; Phinney Donald G; Prockop Darwin J; O'Connor Kim C
Review: ex vivo engineering of living tissues with adult stem cells.
Tissue engineering 2006;12(11):3007-19.
2006: Lee Ryang Hwa; Seo Min Jeong; Reger Roxanne L; Spees Jeffrey L; Pulin Andrey A; Olson Scott D; Prockop Darwin J
Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17438-43.
2006: Peister Alexandra; Zeitouni Suzanne; Pfankuch Timothy; Reger Roxanne L; Prockop Darwin J; Raber Jacob
Novel object recognition in Apoe(-/-) mice improved by neonatal implantation of wild-type multipotential stromal cells.
Experimental neurology 2006;201(1):266-9.
2006: Weiss Daniel J; Berberich Mary Anne; Borok Zea; Gail Dorothy B; Kolls Jay K; Penland Christopher; Prockop Darwin J
Adult stem cells, lung biology, and lung disease. NHLBI/Cystic Fibrosis Foundation Workshop.
Proceedings of the American Thoracic Society 2006;3(3):193-207.
2006: Gunn William G; Conley Adam; Deininger Lisa; Olson Scott D; Prockop Darwin J; Gregory Carl A
A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma.
Stem cells (Dayton, Ohio) 2006;24(4):986-91.
2006: Ylöstalo Joni; Smith Jason R; Pochampally Radhika R; Matz Robert; Sekiya Ichiro; Larson Benjamin L; Vuoristo Jussi T; Prockop Darwin J
Use of differentiating adult stem cells (marrow stromal cells) to identify new downstream target genes for transcription factors.
Stem cells (Dayton, Ohio) 2006;24(3):642-52.
2006: Lee Ryang Hwa; Hsu Shu Ching; Munoz James; Jung Jin Sup; Lee Na Rea; Pochampally Radhika; Prockop Darwin J
A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice.
Blood 2006;107(5):2153-61.
2006: Spees Jeffrey L; Olson Scott D; Whitney Mandolin J; Prockop Darwin J
Mitochondrial transfer between cells can rescue aerobic respiration.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1283-8.
2005: Munoz James R; Stoutenger Brooke R; Robinson Andrew P; Spees Jeffrey L; Prockop Darwin J
Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):18171-6.
2005: Nieminen J; Sahlman J; Hirvonen T; Jämsä T; Tuukkanen J; Kovanen V; Kröger H; Jurvelin J; Arita M; Li S W; Prockop D J; Hyttinen M M; Helminen H J; Lapveteläinen T; Puustjärvi K
Abnormal response to physical activity in femurs after heterozygous inactivation of one allele of the Col2a1 gene for type II collagen in mice.
Calcified tissue international 2005;77(2):104-12.
2005: Gregory Carl A; Ylostalo Joni; Prockop Darwin J
Adult bone marrow stem/progenitor cells (MSCs) are preconditioned by microenvironmental "niches" in culture: a two-stage hypothesis for regulation of MSC fate.
Science's STKE : signal transduction knowledge environment 2005;2005(294):pe37.
2005: Pochampally R R; Horwitz E M; DiGirolamo C M; Stokes D S; Prockop D J
Correction of a mineralization defect by overexpression of a wild-type cDNA for COL1A1 in marrow stromal cells (MSCs) from a patient with osteogenesis imperfecta: a strategy for rescuing mutations that produce dominant-negative protein defects.
Gene therapy 2005;12(14):1119-25.
2005: Prockop Darwin J
Type II collagen and avascular necrosis of the femoral head.
The New England journal of medicine 2005;352(22):2268-70.
2005: Gregory Carl A; Prockop Darwin J; Spees Jeffrey L
Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation.
Experimental cell research 2005;306(2):330-5.
2005: Gregory Carl A; Gunn William G; Reyes Emigdio; Smolarz Angela J; Munoz James; Spees Jeffrey L; Prockop Darwin J
How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow.
Annals of the New York Academy of Sciences 2005;1049():97-106.
2005: Sekiya Ichiro; Larson Benjamin L; Vuoristo Jussi T; Reger Roxanne L; Prockop Darwin J
Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma.
Cell and tissue research 2005;320(2):269-76.
2005: Wang Guoshun; Bunnell Bruce A; Painter Richard G; Quiniones Blesilda C; Tom Susan; Lanson Nicholas A; Spees Jeffrey L; Bertucci Donna; Peister Alexandra; Weiss Daniel J; Valentine Vincent G; Prockop Darwin J; Kolls Jay K
Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):186-91.
2005: Gregory Carl A; Perry Anthony S; Reyes Emigdio; Conley Adam; Gunn W Grady; Prockop Darwin J
Dkk-1-derived synthetic peptides and lithium chloride for the control and recovery of adult stem cells from bone marrow.
The Journal of biological chemistry 2005;280(3):2309-23.
2004: Schouten Joost W; Fulp Carl T; Royo Nicolas C; Saatman Kathryn E; Watson Deborah J; Snyder Evan Y; Trojanowski John Q; Prockop Darwin J; Maas Andrew I R; McIntosh Tracy K
A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury.
Journal of neurotrauma 2004;21(11):1501-38.
2004: Sahlman Janne; Pitkänen Marja T; Prockop Darwin J; Arita Machiko; Li Shi-Wu; Helminen Heikki J; Långsjö Teemu K; Puustjärvi Kaija; Lammi Mikko J
A human COL2A1 gene with an Arg519Cys mutation causes osteochondrodysplasia in transgenic mice.
Arthritis and rheumatism 2004;50(10):3153-60.
2004: Pochampally Radhika R; Neville Brian T; Schwarz Emily J; Li Marilyn M; Prockop Darwin J
Rat adult stem cells (marrow stromal cells) engraft and differentiate in chick embryos without evidence of cell fusion.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9282-5.
2004: Gregory Carl A; Gunn W Grady; Peister Alexandra; Prockop Darwin J
An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction.
Analytical biochemistry 2004;329(1):77-84.
2004: Prockop Darwin J
Targeting gene therapy for osteogenesis imperfecta.
The New England journal of medicine 2004;350(22):2302-4.
2004: Spees Jeffrey L; Gregory Carl A; Singh Harpreet; Tucker H Alan; Peister Alexandra; Lynch Patrick J; Hsu Shu-Ching; Smith Jason; Prockop Darwin J
Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(5):747-56.
2004: Pochampally Radhika R; Smith Jason R; Ylostalo Joni; Prockop Darwin J
Serum deprivation of human marrow stromal cells (hMSCs) selects for a subpopulation of early progenitor cells with enhanced expression of OCT-4 and other embryonic genes.
Blood 2004;103(5):1647-52.
2004: Peister Alexandra; Mellad Jason A; Larson Benjamin L; Hall Brett M; Gibson Laura F; Prockop Darwin J
Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential.
Blood 2004;103(5):1662-8.
2004: Sekiya Ichiro; Larson Benjamin L; Vuoristo Jussi T; Cui Jian-Guo; Prockop Darwin J
Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(2):256-64.
2004: Peister A; Mellad J A; Wang M; Tucker H A; Prockop D J
Stable transfection of MSCs by electroporation.
Gene therapy 2004;11(2):224-8.
2004: Smith Jason R; Pochampally Radhika; Perry Anthony; Hsu Shu-Ching; Prockop Darwin J
Isolation of a highly clonogenic and multipotential subfraction of adult stem cells from bone marrow stroma.
Stem cells (Dayton, Ohio) 2004;22(5):823-31.
2003: Prockop Darwin J; Gregory Carl A; Spees Jeffery L
One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues.
Proceedings of the National Academy of Sciences of the United States of America 2003;100 Suppl 1():11917-23.
2003: Gregory Carl A; Singh Harpreet; Perry Anthony S; Prockop Darwin J
The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow.
The Journal of biological chemistry 2003;278(30):28067-78.
2003: Prockop Darwin J
Further proof of the plasticity of adult stem cells and their role in tissue repair.
The Journal of cell biology 2003;160(6):807-9.
2003: Spees Jeffrey L; Olson Scott D; Ylostalo Joni; Lynch Patrick J; Smith Jason; Perry Anthony; Peister Alexandra; Wang Meng Yu; Prockop Darwin J
Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2397-402.
2002: Prockop Darwin J
Adult stem cells gradually come of age.
Nature biotechnology 2002;20(8):791-2.
2002: Sekiya Ichiro; Vuoristo Jussi T; Larson Benjamin L; Prockop Darwin J
In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4397-402.
2002: Hofstetter C P; Schwarz E J; Hess D; Widenfalk J; El Manira A; Prockop Darwin J; Olson L
Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2199-204.
2002: Colige Alain; Vandenberghe Isabel; Thiry Marc; Lambert Charles A; Van Beeumen Jozef; Li Shi-Wu; Prockop Darwin J; Lapiere Charles M; Nusgens Betty V
Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.
The Journal of biological chemistry 2002;277(8):5756-66.
2002: Sekiya Ichiro; Larson Benjamin L; Smith Jason R; Pochampally Radhika; Cui Jian-Guo; Prockop Darwin J
Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality.
Stem cells (Dayton, Ohio) 2002;20(6):530-41.
2001: Sahlman J; Inkinen R; Hirvonen T; Lammi M J; Lammi P E; Nieminen J; Lapveteläinen T; Prockop D J; Arita M; Li S W; Hyttinen M M; Helminen H J; Puustjärvi K
Premature vertebral endplate ossification and mild disc degeneration in mice after inactivation of one allele belonging to the Col2a1 gene for Type II collagen.
Spine 2001;26(23):2558-65.
2001: Li S W; Takanosu M; Arita M; Bao Y; Ren Z X; Maier A; Prockop D J; Mayne R
Targeted disruption of Col11a2 produces a mild cartilage phenotype in transgenic mice: comparison with the human disorder otospondylomegaepiphyseal dysplasia (OSMED).
Developmental dynamics : an official publication of the American Association of Anatomists 2001;222(2):141-52.
2001: Schwarz E J; Reger R L; Alexander G M; Class R; Azizi S A; Prockop D J
Rat marrow stromal cells rapidly transduced with a self-inactivating retrovirus synthesize L-DOPA in vitro.
Gene therapy 2001;8(16):1214-23.
2001: Colter D C; Sekiya I; Prockop D J
Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7841-5.
2001: Sekiya I; Colter D C; Prockop D J
BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells.
Biochemical and biophysical research communications 2001;284(2):411-8.
2001: Li S W; Arita M; Fertala A; Bao Y; Kopen G C; Långsjö T K; Hyttinen M M; Helminen H J; Prockop D J
Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility.
The Biochemical journal 2001;355(Pt 2):271-8.
2001: Deng W; Obrocka M; Fischer I; Prockop D J
In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP.
Biochemical and biophysical research communications 2001;282(1):148-52.
2001: Hyttinen M M; Töyräs J; Lapveteläinen T; Lindblom J; Prockop D J; Li S W; Arita M; Jurvelin J S; Helminen H J
Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer.
Annals of the rheumatic diseases 2001;60(3):262-8.
2001: Lapveteläinen T; Hyttinen M; Lindblom J; Långsjö T K; Sironen R; Li S W; Arita M; Prockop D J; Puustjärvi K; Helminen H J
More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(2):152-60.
2001: Prockop D J; Sekiya I; Colter D C
Isolation and characterization of rapidly self-renewing stem cells from cultures of human marrow stromal cells.
Cytotherapy 2001;3(5):393-6.
2001: Javazon E H; Colter D C; Schwarz E J; Prockop D J
Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells.
Stem cells (Dayton, Ohio) 2001;19(3):219-25.
2000: Vuoristo J T; Berrettini W H; Overhauser J; Prockop D J; Ferraro T N; Ala-Kokko L
Sequence and genomic organization of the human G-protein Golfalpha gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia.
Molecular psychiatry 2000;5(5):495-501.
2000: Körkkö J; Cohn D H; Ala-Kokko L; Krakow D; Prockop D J
Widely distributed mutations in the COL2A1 gene produce achondrogenesis type II/hypochondrogenesis.
American journal of medical genetics 2000;92(2):95-100.
2000: Colter D C; Class R; DiGirolamo C M; Prockop D J
Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3213-8.
2000: Yuan C M; Ala-Kokko L; Le Guellec D; Franc S; Fertala A; Khillan J S; Sokolov B P; Prockop D J
Lack of a phenotype in transgenic mice aberrantly expressing COL2A1 mRNA because of highly selective post-transcriptional down-regulation.
The Biochemical journal 2000;345 Pt 2():377-84.
2000: Prockop D J; Azizi S A; Phinney D G; Kopen G C; Schwarz E J
Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system.
Progress in brain research 2000;128():293-7.
2000: Prockop D J; Azizi S A; Colter D; Digirolamo C; Kopen G; Phinney D G
Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system.
Biochemical Society transactions 2000;28(4):341-5.
1999: Phinney D G; Kopen G; Righter W; Webster S; Tremain N; Prockop D J
Donor variation in the growth properties and osteogenic potential of human marrow stromal cells.
Journal of cellular biochemistry 1999;75(3):424-36.
1999: Digirolamo C M; Stokes D; Colter D; Phinney D G; Class R; Prockop D J
Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate.
British journal of haematology 1999;107(2):275-81.
1999: Schwarz E J; Alexander G M; Prockop D J; Azizi S A
Multipotential marrow stromal cells transduced to produce L-DOPA: engraftment in a rat model of Parkinson disease.
Human gene therapy 1999;10(15):2539-49.
1999: Annunen S; Körkkö J; Czarny M; Warman M L; Brunner H G; Kääriäinen H; Mulliken J B; Tranebjaerg L; Brooks D G; Cox G F; Cruysberg J R; Curtis M A; Davenport S L; Friedrich C A; Kaitila I; Krawczynski M R; Latos-Bielenska A; Mukai S; Olsen B R; Shinno N; Somer M; Vikkula M; Zlotogora J; Prockop D J; Ala-Kokko L
Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes.
American journal of human genetics 1999;65(4):974-83.
1999: Kopen G C; Prockop D J; Phinney D G
Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10711-6.
1999: Paassilta P; Pihlajamaa T; Annunen S; Brewton R G; Wood B M; Johnson C C; Liu J; Gong Y; Warman M L; Prockop D J; Mayne R; Ala-Kokko L
Complete sequence of the 23-kilobase human COL9A3 gene. Detection of Gly-X-Y triplet deletions that represent neutral variants.
The Journal of biological chemistry 1999;274(32):22469-75.
1999: Colige A; Sieron A L; Li S W; Schwarze U; Petty E; Wertelecki W; Wilcox W; Krakow D; Cohn D H; Reardon W; Byers P H; Lapière C M; Prockop D J; Nusgens B V
Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene.
American journal of human genetics 1999;65(2):308-17.
1999: Annunen S; Paassilta P; Lohiniva J; Perälä M; Pihlajamaa T; Karppinen J; Tervonen O; Kröger H; Lähde S; Vanharanta H; Ryhänen L; Göring H H; Ott J; Prockop D J; Ala-Kokko L
An allele of COL9A2 associated with intervertebral disc disease.
Science (New York, N.Y.) 1999;285(5426):409-12.
1999: Kopen G C; Prockop D J; Phinney D G
Enhanced in situ detection of beta-glucuronidase activity in murine tissue.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999;47(7):965-8.
1999: Phinney D G; Kopen G; Isaacson R L; Prockop D J
Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth, and differentiation.
Journal of cellular biochemistry 1999;72(4):570-85.
1999: Prockop D J
Hopkins Memorial Medal lecture. Pleasant surprises en route from the biochemistry of collagen to attempts at gene therapy.
Biochemical Society transactions 1999;27(2):15-31.
1998: Arnold W V; Fertala A; Sieron A L; Hattori H; Mechling D; Bächinger H P; Prockop D J
Recombinant procollagen II: Deletion of D period segments identifies sequences that are required for helix stabilization and generates a temperature-sensitive N-proteinase cleavage site.
The Journal of biological chemistry 1998;273(48):31822-8.
1998: Pihlajamaa T; Prockop D J; Faber J; Winterpacht A; Zabel B; Giedion A; Wiesbauer P; Spranger J; Ala-Kokko L
Heterozygous glycine substitution in the COL11A2 gene in the original patient with the Weissenbacher-Zweymüller syndrome demonstrates its identity with heterozygous OSMED (nonocular Stickler syndrome).
American journal of medical genetics 1998;80(2):115-20.
1998: Pihlajamaa T; Vuoristo M M; Annunen S; Perälä M; Prockop D J; Ala-Kokko L
Human COL9A1 and COL9A2 genes. Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule.
Matrix biology : journal of the International Society for Matrix Biology 1998;17(3):237-41.
1998: Li S W; Arita M; Kopen G C; Phinney D G; Prockop D J
A 1,064 bp fragment from the promoter region of the Col11a2 gene drives lacZ expression not only in cartilage but also in osteoblasts adjacent to regions undergoing both endochondral and intramembranous ossification in mouse embryos.
Matrix biology : journal of the International Society for Matrix Biology 1998;17(3):213-21.
1998: Prockop D J; Fertala A
Inhibition of the self-assembly of collagen I into fibrils with synthetic peptides. Demonstration that assembly is driven by specific binding sites on the monomers.
The Journal of biological chemistry 1998;273(25):15598-604.
1998: Prockop D J
What holds us together? Why do some of us fall apart? What can we do about it?
Matrix biology : journal of the International Society for Matrix Biology 1998;16(9):519-28.
1998: Azizi S A; Stokes D; Augelli B J; DiGirolamo C; Prockop D J
Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats--similarities to astrocyte grafts.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3908-13.
1998: Prockop D J; Sieron A L; Li S W
Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling.
Matrix biology : journal of the International Society for Matrix Biology 1998;16(7):399-408.
1998: Körkkö J; Annunen S; Pihlajamaa T; Prockop D J; Ala-Kokko L
Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: comparison with denaturing gradient gel electrophoresis and nucleotide sequencing.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1681-5.
1998: Pereira R F; O'Hara M D; Laptev A V; Halford K W; Pollard M D; Class R; Simon D; Livezey K; Prockop D J
Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1142-7.
1998: Körkkö J; Ala-Kokko L; De Paepe A; Nuytinck L; Earley J; Prockop D J
Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type I: identification of common sequences of null-allele mutations.
American journal of human genetics 1998;62(1):98-110.
1998: Körkkö J; Milunsky J; Prockop D J; Ala-Kokko L
Use of conformation sensitive gel electrophoresis to detect single-base changes in the gene for COL10A1.
Human mutation 1998;Suppl 1():S201-3.
1997: Zafarullah K; Sieron A L; Fertala A; Tromp G; Kuivaniemi H; Prockop D J
A recombinant homotrimer of type I procollagen that lacks the central two D-periods. The thermal stability of the triple helix is decreased by 2 to 4 degrees C.
Matrix biology : journal of the International Society for Matrix Biology 1997;16(5):245-53.
1997: Zafarullah K; Brown E M; Kuivaniemi H; Tromp G; Sieron A L; Fertala A; Prockop D J
Synthesis and conformational properties of a recombinant C-propeptide of human type III procollagen.
Matrix biology : journal of the International Society for Matrix Biology 1997;16(4):201-9.
1997: Yang C; Li S W; Helminen H J; Khillan J S; Bao Y; Prockop D J
Apoptosis of chondrocytes in transgenic mice lacking collagen II.
Experimental cell research 1997;235(2):370-3.
1997: Arnold W V; Sieron A L; Fertala A; Bächinger H P; Mechling D; Prockop D J
A cDNA cassette system for the synthesis of recombinant procollagens. Variants of procollagen II lacking a D-period are secreted as triple-helical monomers.
Matrix biology : journal of the International Society for Matrix Biology 1997;16(3):105-16.
1997: Jimenez S A; Ala-Kokko L; Prockop D J; Merryman C F; Shepard N; Dodge G R
Characterization of human type II procollagen and collagen-specific antibodies and their application to the study of human type II collagen processing and ultrastructure.
Matrix biology : journal of the International Society for Matrix Biology 1997;16(1):29-39.
1997: Prockop D J
Marrow stromal cells as stem cells for nonhematopoietic tissues.
Science (New York, N.Y.) 1997;276(5309):71-4.
1997: Colige A; Li S W; Sieron A L; Nusgens B V; Prockop D J; Lapière C M
cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2374-9.
1997: Fertala A; Ala-Kokko L; Wiaderkiewicz R; Prockop D J
Collagen II containing a Cys substitution for arg-alpha1-519. Homotrimeric monomers containing the mutation do not assemble into fibrils but alter the self-assembly of the normal protein.
The Journal of biological chemistry 1997;272(10):6457-64.
1997: Körkkö J; Kuivaniemi H; Paassilta P; Zhuang J; Tromp G; DePaepe A; Prockop D J; Ala-Kokko L
Two new recurrent nucleotide mutations in the COL1A1 gene in four patients with osteogenesis imperfecta: about one-fifth are recurrent.
Human mutation 1997;9(2):148-56.
1996: Vandenberg P; Vuoristo M M; Ala-Kokko L; Prockop D J
The mouse col11a2 gene. Some transcripts from the adjacent rxr-beta gene extend into the col11a2 gene.
Matrix biology : journal of the International Society for Matrix Biology 1996;15(5):359-67.
1996: Spotila L D; Caminis J; Johnston R; Shimoya K S; O'Connor M P; Prockop D J; Tenenhouse A; Tenenhouse H S
Vitamin D receptor genotype is not associated with bone mineral density in three ethnic/regional groups.
Calcified tissue international 1996;59(4):235-7.
1996: Cassella J P; Pereira R; Prockop D J; Ali S Y
Mineral changes in a transgenic mouse model for osteogenesis imperfecta.
British journal of biomedical science 1996;53(2):108-15.
1996: Williams C J; Ganguly A; Considine E; McCarron S; Prockop D J; Walsh-Vockley C; Michels V V
A-2-->G transition at the 3' acceptor splice site of IVS17 characterizes the COL2A1 gene mutation in the original Stickler syndrome kindred.
American journal of medical genetics 1996;63(3):461-7.
1996: Vuoristo M M; Pihlajamaa T; Vandenberg P; Körkkö J; Prockop D J; Ala-Kokko L
Complete structure of the human COL11A2 gene: the exon sizes and other features indicate the gene has not evolved with genes for other fibriller collagens.
Annals of the New York Academy of Sciences 1996;785():343-4.
1996: Fertala A; Ala-Kokko L; Prockop D J
Characterization of recombinant human collagen II with Arg519-to-Cys substitution.
Annals of the New York Academy of Sciences 1996;785():251-3.
1996: Bleasel J F; Holderbaum D; Brancolini V; Moskowitz R W; Haqqi T M; Considine E; Prockop D J; Devoto M; Williams C J
Arg519-Cys mutation in COL2A1: evidence for multiple founders.
Annals of the New York Academy of Sciences 1996;785():215-8.
1996: Arnold W V; Sieron A L; Prockop D J
Creation of a system for the assembly and expression of DNA constructs encoding novel recombinant human procollagen II.
Annals of the New York Academy of Sciences 1996;785():204-5.
1996: Ala-Kokko L; Yuan C M; Le Guellec D; Franc S; Fertala A; Khillan J S; Sokolov B P; Prockop D J
A 1.9-Kb 5' fragment from the human COL1A1 gene drives inappropriate expression of the human COL2A1 gene in tissues of transgenic mice that normally express only the COL1A1 gene.
Annals of the New York Academy of Sciences 1996;785():202-3.
1996: Fertala A; Holmes D F; Kadler K E; Sieron A L; Prockop D J
Assembly in vitro of thin and thick fibrils of collagen II from recombinant procollagen II. The monomers in the tips of thick fibrils have the opposite orientation from monomers in the growing tips of collagen I fibrils.
The Journal of biological chemistry 1996;271(25):14864-9.
1996: Spotila L D; Caminis J; Devoto M; Shimoya K; Sereda L; Ott J; Whyte M P; Tenenhouse A; Prockop D J
Osteopenia in 37 members of seven families: analysis based on a model of dominant inheritance.
Molecular medicine (Cambridge, Mass.) 1996;2(3):313-24.
1996: Li S W; Sieron A L; Fertala A; Hojima Y; Arnold W V; Prockop D J
The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):5127-30.
1996: Li S W; Nembhard K M; Prockop D J; Khillan J S
Identification and cloning of integration site of DNA by PCR.
BioTechniques 1996;20(3):356-8.
1996: Zhuang J; Tromp G; Kuivaniemi H; Castells S; Prockop D J
Substitution of arginine for glycine at position 154 of the alpha 1 chain of type I collagen in a variant of osteogenesis imperfecta: comparison to previous cases with the same mutation.
American journal of medical genetics 1996;61(2):111-16.
1996: Zhuang J; Tromp G; Kuivaniemi H; Castells S; Bugge M; Prockop D J
Direct sequencing of PCR products derived from cDNAs for the pro alpha 1 and pro alpha 2 chains of type I procollagen as a screening method to detect mutations in patients with osteogenesis imperfecta.
Human mutation 1996;7(2):89-99.
1995: Pereira R F; Hume E L; Halford K W; Prockop D J
Bone fragility in transgenic mice expressing a mutated gene for type I procollagen (COL1A1) parallels the age-dependent phenotype of human osteogenesis imperfecta.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995;10(12):1837-43.
1995: Vuristo M M; Pihlajamaa T; Vandenberg P; Prockop D J; Ala-Kokko L
The human COL11A2 gene structure indicates that the gene has not evolved with the genes for the major fibrillar collagens.
The Journal of biological chemistry 1995;270(39):22873-81.
1995: Li S W; Khillan J; Prockop D J
The complete cDNA coding sequence for the mouse pro alpha 1(I) chain of type I procollagen.
Matrix biology : journal of the International Society for Matrix Biology 1995;14(7):593-5.
1995: Ala-Kokko L; Kvist A P; Metsäranta M; Kivirikko K I; de Crombrugghe B; Prockop D J; Vuorio E
Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1).
The Biochemical journal 1995;308 ( Pt 3)():923-9.
1995: Pereira R F; Halford K W; O'Hara M D; Leeper D B; Sokolov B P; Pollard M D; Bagasra O; Prockop D J
Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4857-61.
1995: Bonaventure J; Cohen-Solal L; Ritvaniemi P; Van Maldergem L; Kadhom N; Delezoide A L; Maroteaux P; Prockop D J; Ala-Kokko L
Substitution of aspartic acid for glycine at position 310 in type II collagen produces achondrogenesis II, and substitution of serine at position 805 produces hypochondrogenesis: analysis of genotype-phenotype relationships.
The Biochemical journal 1995;307 ( Pt 3)():823-30.
1995: Sokolov B P; Ala-Kokko L; Dhulipala R; Arita M; Khillan J S; Prockop D J
Tissue-specific expression of the gene for type I procollagen (COL1A1) in transgenic mice. Only 476 base pairs of the promoter are required if collagen genes are used as reporters.
The Journal of biological chemistry 1995;270(16):9622-9.
1995: Williams C J; Rock M; Considine E; McCarron S; Gow P; Ladda R; McLain D; Michels V M; Murphy W; Prockop D J
Three new point mutations in type II procollagen (COL2A1) and identification of a fourth family with the COL2A1 Arg519-->Cys base substitution using conformation sensitive gel electrophoresis.
Human molecular genetics 1995;4(2):309-12.
1995: Prockop D J; Kivirikko K I
Collagens: molecular biology, diseases, and potentials for therapy.
Annual review of biochemistry 1995;64():403-34.
1994: Hojima Y; Behta B; Romanic A M; Prockop D J
Cleavage of type I procollagen by C- and N-proteinases is more rapid if the substrate is aggregated with dextran sulfate or polyethylene glycol.
Analytical biochemistry 1994;223(2):173-80.
1994: Cassella J P; Pereira R; Khillan J S; Prockop D J; Garrington N; Ali S Y
An ultrastructural, microanalytical, and spectroscopic study of bone from a transgenic mouse with a COL1.A1 pro-alpha-1 mutation.
Bone 1994;15(6):611-9.
1994: Laptev A V; Lu Z; Colige A; Prockop D J
Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA.
Biochemistry 1994;33(36):11033-9.
1994: Sokolov B P; Prockop D J
A rapid and simple PCR-based method for isolation of cDNAs from differentially expressed genes.
Nucleic acids research 1994;22(19):4009-15.
1994: Ganguly A; Smelt S; Mewar R; Fertala A; Sieron A L; Overhauser J; Prockop D J
Targeted insertions of two exogenous collagen genes into both alleles of their endogenous loci in cultured human cells: the insertions are directed by relatively short fragments containing the promoters and the 5' ends of the genes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7365-9.
1994: Khillan J S; Li S W; Prockop D J
Partial rescue of a lethal phenotype of fragile bones in transgenic mice with a chimeric antisense gene directed against a mutated collagen gene.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6298-302.
1994: Earley J J; Kuivaniemi H; Prockop D J; Tromp G
Robotic automation of dideoxyribonucleotide sequencing reactions.
BioTechniques 1994;17(1):156-8, 160, 162-5.
1994: Prockop D J; Kuivaniemi H; Tromp G
Molecular basis of osteogenesis imperfecta and related disorders of bone.
Clinics in plastic surgery 1994;21(3):407-13.
1994: Freisinger P; Ala-Kokko L; LeGuellec D; Franc S; Bouvier R; Ritvaniemi P; Prockop D J; Bonaventure J
Mutation in the COL2A1 gene in a patient with hypochondrogenesis. Expression of mutated COL2A1 gene is accompanied by expression of genes for type I procollagen in chondrocytes.
The Journal of biological chemistry 1994;269(18):13663-9.
1994: Pereira R; Halford K; Sokolov B P; Khillan J S; Prockop D J
Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1).
The Journal of clinical investigation 1994;93(4):1765-9.
1994: Romanic A M; Spotila L D; Adachi E; Engel J; Hojima Y; Prockop D J
Self-assembly of collagen I from a proband homozygous for a mutation that substituted serine for glycine at position 661 in the alpha 2(I) chain. Possible relationship between the effects of mutations on critical concentration and the severity of the phenotype.
The Journal of biological chemistry 1994;269(15):11614-9.
1994: Fertala A; Sieron A L; Hojima Y; Ganguly A; Prockop D J
Self-assembly into fibrils of collagen II by enzymic cleavage of recombinant procollagen II. Lag period, critical concentration, and morphology of fibrils differ from collagen I.
The Journal of biological chemistry 1994;269(15):11584-9.
1994: Hojima Y; Mörgelin M M; Engel J; Boutillon M M; van der Rest M; McKenzie J; Chen G C; Rafi N; Romanic A M; Prockop D J
Characterization of type I procollagen N-proteinase from fetal bovine tendon and skin. Purification of the 500-kilodalton form of the enzyme from bovine tendon.
The Journal of biological chemistry 1994;269(15):11381-90.
1994: Hojima Y; Behta B; Romanic A M; Prockop D J
Cadmium ions inhibit procollagen C-proteinase and cupric ions inhibit procollagen N-proteinase.
Matrix biology : journal of the International Society for Matrix Biology 1994;14(2):113-20.
1994: Fertala A; Sieron A L; Ganguly A; Li S W; Ala-Kokko L; Anumula K R; Prockop D J
Synthesis of recombinant human procollagen II in a stably transfected tumour cell line (HT1080).
The Biochemical journal 1994;298 ( Pt 1)():31-7.
1994: Ritvaniemi P; Sokolov B P; Williams C J; Considine E; Yurgenev L; Meerson E M; Ala-Kokko L; Prockop D J
A single base mutation in the type II procollagen gene (COL2A1) that converts glycine alpha 1-247 to serine in a family with late-onset spondyloepiphyseal dysplasia.
Human mutation 1994;3(3):261-7.
1993: Kuivaniemi H; Prockop D J; Wu Y; Madhatheri S L; Kleinert C; Earley J J; Jokinen A; Stolle C; Majamaa K; Myllylä V V
Exclusion of mutations in the gene for type III collagen (COL3A1) as a common cause of intracranial aneurysms or cervical artery dissections: results from sequence analysis of the coding sequences of type III collagen from 55 unrelated patients.
Neurology 1993;43(12):2652-8.
1993: Prockop D J; Colige A; Helminen H; Khillan J S; Pereira R; Vandenberg P
Mutations in type 1 procollagen that cause osteogenesis imperfecta: effects of the mutations on the assembly of collagen into fibrils, the basis of phenotypic variations, and potential antisense therapies.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8 Suppl 2():S489-92.
1993: Williams C J; Considine E L; Knowlton R G; Reginato A; Neumann G; Harrison D; Buxton P; Jimenez S; Prockop D J
Spondyloepiphyseal dysplasia and precocious osteoarthritis in a family with an Arg75-->Cys mutation in the procollagen type II gene (COL2A1).
Human genetics 1993;92(5):499-505.
1993: Ganguly A; Rock M J; Prockop D J
Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10325-9.
1993: Sieron A L; Fertala A; Ala-Kokko L; Prockop D J
Deletion of a large domain in recombinant human procollagen II does not alter the thermal stability of the triple helix.
The Journal of biological chemistry 1993;268(28):21232-7.
1993: Sokolov B P; Mays P K; Khillan J S; Prockop D J
Tissue- and development-specific expression in transgenic mice of a type I procollagen (COL1A1) minigene construct with 2.3 kb of the promoter region and 2 kb of the 3'-flanking region. Specificity is independent of the putative regulatory sequences in the first intron.
Biochemistry 1993;32(35):9242-9.
1993: Geddis A E; Prockop D J
Expression of human COL1A1 gene in stably transfected HT1080 cells: the production of a thermostable homotrimer of type I collagen in a recombinant system.
Matrix (Stuttgart, Germany) 1993;13(5):399-405.
1993: Ritvaniemi P; Hyland J; Ignatius J; Kivirikko K I; Prockop D J; Ala-Kokko L
A fourth example suggests that premature termination codons in the COL2A1 gene are a common cause of the Stickler syndrome: analysis of the COL2A1 gene by denaturing gradient gel electrophoresis.
Genomics 1993;17(1):218-21.
1993: Körkkö J; Ritvaniemi P; Haataja L; Kääriäinen H; Kivirikko K I; Prockop D J; Ala-Kokko L
Mutation in type II procollagen (COL2A1) that substitutes aspartate for glycine alpha 1-67 and that causes cataracts and retinal detachment: evidence for molecular heterogeneity in the Wagner syndrome and the Stickler syndrome (arthro-ophthalmopathy)
American journal of human genetics 1993;53(1):55-61.
1993: Tromp G; Wu Y; Prockop D J; Madhatheri S L; Kleinert C; Earley J J; Zhuang J; Norrgård O; Darling R C; Abbott W M
Sequencing of cDNA from 50 unrelated patients reveals that mutations in the triple-helical domain of type III procollagen are an infrequent cause of aortic aneurysms.
The Journal of clinical investigation 1993;91(6):2539-45.
1993: Zhuang J; Tromp G; Kuivaniemi H; Nakayasu K; Prockop D J
Deletion of 19 base pairs in intron 13 of the gene for the pro alpha 2(I) chain of type-I procollagen (COL1A2) causes exon skipping in a proband with type-I osteogenesis imperfecta.
Human genetics 1993;91(3):210-6.
1993: Pereira R; Khillan J S; Helminen H J; Hume E L; Prockop D J
Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral.
The Journal of clinical investigation 1993;91(2):709-16.
1993: Constantinou-Deltas C D; Ladda R L; Prockop D J
Somatic cell mosaicism: another source of phenotypic heterogeneity in nuclear families with osteogenesis imperfecta.
American journal of medical genetics 1993;45(2):246-51.
1993: Ahmad N N; McDonald-McGinn D M; Zackai E H; Knowlton R G; LaRossa D; DiMascio J; Prockop D J
A second mutation in the type II procollagen gene (COL2AI) causing stickler syndrome (arthro-ophthalmopathy) is also a premature termination codon.
American journal of human genetics 1993;52(1):39-45.
1993: Harrison D; Baldwin C; Prockop D J
Use of an automated workstation to facilitate PCR amplification, loading agarose gels and sequencing of DNA templates.
BioTechniques 1993;14(1):88-97.
1993: Fertala A; Westerhausen A; Morris G; Rooney J E; Prockop D J
Two cysteine substitutions in procollagen I: a glycine replacement near the N-terminus of alpha 1(I) chain causes lethal osteogenesis imperfecta and a glycine replacement in the alpha 2(I) chain markedly destabilizes the triple helix.
The Biochemical journal 1993;289 ( Pt 1)():195-9.
1993: Colige A; Sokolov B P; Nugent P; Baserga R; Prockop D J
Use of an antisense oligonucleotide to inhibit expression of a mutated human procollagen gene (COL1A1) in transfected mouse 3T3 cells.
Biochemistry 1993;32(1):7-11.
1993: Wu Y; Kuivaniemi H; Tromp G; Strobel D; Romanic A M; Prockop D J
Temperature sensitivity of aberrant RNA splicing with a mutation in the G+5 position of intron 37 of the gene for type III procollagen from a patient with Ehlers-Danlos syndrome type IV.
Human mutation 1993;2(1):28-36.
1993: Earley J J; Kuivaniemi H; Prockop D J; Tromp G
Efficient DNA sequencing on microtiter plates using dried reagents and Bst DNA polymerase.
DNA sequence : the journal of DNA sequencing and mapping 1993;4(2):79-85.
1992: Spotila L D; Sereda L; Prockop D J
Partial isodisomy for maternal chromosome 7 and short stature in an individual with a mutation at the COL1A2 locus.
American journal of human genetics 1992;51(6):1396-405.
1992: Romanic A M; Adachi E; Hojima Y; Engel J; Prockop D J
Polymerization of pNcollagen I and copolymerization of pNcollagen I with collagen I. A kinetic, thermodynamic, and morphologic study.
The Journal of biological chemistry 1992;267(31):22265-71.
1992: Kontusaari S; Tromp G; Kuivaniemi H; Stolle C; Pope F M; Prockop D J
Substitution of aspartate for glycine 1018 in the type III procollagen (COL3A1) gene causes type IV Ehlers-Danlos syndrome: the mutated allele is present in most blood leukocytes of the asymptomatic and mosaic mother.
American journal of human genetics 1992;51(3):497-507.
1992: McBride D J; Kadler K E; Hojima Y; Prockop D J
Self-assembly into fibrils of a homotrimer of type I collagen.
Matrix (Stuttgart, Germany) 1992;12(4):256-63.
1992: Ala-Kokko L; Günzler V; Hoek J B; Rubin E; Prockop D J
Hepatic fibrosis in rats produced by carbon tetrachloride and dimethylnitrosamine: observations suggesting immunoassays of serum for the 7S fragment of type IV collagen are a more sensitive index of liver damage than immunoassays for the NH2-terminal propeptide of type III procollagen.
Hepatology (Baltimore, Md.) 1992;16(1):167-72.
1992: Torre-Blanco A; Adachi E; Romanic A M; Prockop D J
Copolymerization of normal type I collagen with three mutated type I collagens containing substitutions of cysteine at different glycine positions in the alpha 1 (I) chain.
The Journal of biological chemistry 1992;267(7):4968-73.
1992: Torre-Blanco A; Adachi E; Hojima Y; Wootton J A; Minor R R; Prockop D J
Temperature-induced post-translational over-modification of type I procollagen. Effects of over-modification of the protein on the rate of cleavage by procollagen N-proteinase and on self-assembly of collagen into fibrils.
The Journal of biological chemistry 1992;267(4):2650-5.
1992: Prockop D J
Seminars in medicine of the Beth Israel Hospital, Boston. Mutations in collagen genes as a cause of connective-tissue diseases.
The New England journal of medicine 1992;326(8):540-6.
1992: Mays P K; Tromp G; Kuivaniemi H; Ryynänen M; Prockop D J
A 15 base-pair AT-rich variable number tandem repeat in the type III procollagen gene (COL3A1) as an informative marker for 2q31-2q32.3.
Matrix (Stuttgart, Germany) 1992;12(1):44-9.
1992: Hojima Y; McKenzie J; Kadler K E; McBride D J; van der Rest M; Mörgelin M M; Engel J; Prockop D J
A new 500-kDa form of type I procollagen N-proteinase from chick embryo tendons.
Matrix (Stuttgart, Germany). Supplement 1992;1():97-8.
1991: Westerhausen A; Constantinou C D; Pack M; Peng M Z; Hanning C; Olsen A S; Prockop D J
Completion of the last half of the structure of the human gene for the Pro alpha 1 (I) chain of type I procollagen (COL1A1).
Matrix (Stuttgart, Germany) 1991;11(6):375-9.
1991: Khillan J S; Olsen A S; Kontusaari S; Sokolov B; Prockop D J
Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COL1A1) develop a phenotype resembling a lethal form of osteogenesis imperfecta.
The Journal of biological chemistry 1991;266(34):23373-9.
1991: Sokolov B P; Prytkov A N; Tromp G; Knowlton R G; Prockop D J
Exclusion of COL1A1, COL1A2, and COL3A1 genes as candidate genes for Ehlers-Danlos syndrome type I in one large family.
Human genetics 1991;88(2):125-9.
1991: Steinmann B; Westerhausen A; Constantinou C D; Superti-Furga A; Prockop D J
Substitution of cysteine for glycine-alpha 1-691 in the pro alpha 1(I) chain of type I procollagen in a proband with lethal osteogenesis imperfecta destabilizes the triple helix at a site C-terminal to the substitution.
The Biochemical journal 1991;279 ( Pt 3)():747-52.
1991: Kuivaniemi H; Tromp G; Prockop D J
Genetic causes of aortic aneurysms. Unlearning at least part of what the textbooks say.
The Journal of clinical investigation 1991;88(5):1441-4.
1991: Vandenberg P; Khillan J S; Prockop D J; Helminen H; Kontusaari S; Ala-Kokko L
Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7640-4.
1991: Tsuneyoshi T; Sokolov B P; Prockop D J
PCR detection of a HindIII polymorphism in the human gene for type II procollagen (COL2A1).
Nucleic acids research 1991;19(16):4571.
1991: Tsuneyoshi T; Westerhausen A; Constantinou C D; Prockop D J
Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of type I procollagen in lethal osteogenesis imperfecta. The conformational strain on the triple helix introduced by a glycine substitution can be transmitted along the helix.
The Journal of biological chemistry 1991;266(24):15608-13.
1991: Tromp G; Christiano A; Goldstein N; Indik Z; Boyd C; Rosenbloom J; Deak S; Prockop D; Kuivaniemi H
A to G polymorphism in ELN gene.
Nucleic acids research 1991;19(15):4314.
1991: Sokolov B P; Constantinou C D; Tsuneyoshi T; Zhuang J P; Prockop D J
G to A polymorphism in exon 45 of the COL1A1 gene.
Nucleic acids research 1991;19(15):4302.
1991: Ala-Kokko L; Hyland J; Smith C; Kivirikko K I; Jimenez S A; Prockop D J
Expression of a human cartilage procollagen gene (COL2A1) in mouse 3T3 cells.
The Journal of biological chemistry 1991;266(22):14175-8.
1991: Ahmad N N; Ala-Kokko L; Knowlton R G; Jimenez S A; Weaver E J; Maguire J I; Tasman W; Prockop D J
Stop codon in the procollagen II gene (COL2A1) in a family with the Stickler syndrome (arthro-ophthalmopathy).
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6624-7.
1991: Romanic A M; Adachi E; Kadler K E; Hojima Y; Prockop D J
Copolymerization of pNcollagen III and collagen I. pNcollagen III decreases the rate of incorporation of collagen I into fibrils, the amount of collagen I incorporated, and the diameter of the fibrils formed.
The Journal of biological chemistry 1991;266(19):12703-9.
1991: Spotila L D; Constantinou C D; Sereda L; Ganguly A; Riggs B L; Prockop D J
Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5423-7.
1991: Zhuang J P; Constantinou C D; Ganguly A; Prockop D J
A single base mutation in type I procollagen (COL1A1) that converts glycine alpha 1-541 to aspartate in a lethal variant of osteogenesis imperfecta: detection of the mutation with a carbodiimide reaction of DNA heteroduplexes and direct sequencing of products of the PCR.
American journal of human genetics 1991;48(6):1186-91.
1991: Ganguly A; Baldwin C T; Strobel D; Conway D; Horton W; Prockop D J
Heterozygous mutation in the G+5 position of intron 33 of the pro-alpha 2(I) gene (COL1A2) that causes aberrant RNA splicing and lethal osteogenesis imperfecta. Use of carbodiimide methods that decrease the extent of DNA sequencing necessary to define an unusual mutation.
The Journal of biological chemistry 1991;266(18):12035-40.
1991: Kadler K E; Torre-Blanco A; Adachi E; Vogel B E; Hojima Y; Prockop D J
A type I collagen with substitution of a cysteine for glycine-748 in the alpha 1(I) chain copolymerizes with normal type I collagen and can generate fractallike structures.
Biochemistry 1991;30(20):5081-8.
1991: Kuivaniemi H; Tromp G; Prockop D J
Mutations in collagen genes: causes of rare and some common diseases in humans.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(7):2052-60.
1991: Tromp G; Kleinert C; Kuivaniemi H; Prockop D J
C to T polymorphism in exon 33 of the COL3A1 gene.
Nucleic acids research 1991;19(3):681.
1991: Vasan N S; Kuivaniemi H; Vogel B E; Minor R R; Wootton J A; Tromp G; Weksberg R; Prockop D J
A mutation in the pro alpha 2(I) gene (COL1A2) for type I procollagen in Ehlers-Danlos syndrome type VII: evidence suggesting that skipping of exon 6 in RNA splicing may be a common cause of the phenotype.
American journal of human genetics 1991;48(2):305-17.
1991: Olsen A S; Geddis A E; Prockop D J
High levels of expression of a minigene version of the human pro alpha 1 (I) collagen gene in stably transfected mouse fibroblasts. Effects of deleting putative regulatory sequences in the first intron.
The Journal of biological chemistry 1991;266(2):1117-21.
1991: Prockop D J
Mutations in collagen genes as a cause of rare and perhaps common diseases of connective tissue.
Acta paediatrica Scandinavica. Supplement 1991;379():55-7; discussion 58.
1990: Kontusaari S; Tromp G; Kuivaniemi H; Romanic A M; Prockop D J
A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms.
The Journal of clinical investigation 1990;86(5):1465-73.
1990: Ala-Kokko L; Prockop D J
Completion of the intron-exon structure of the gene for human type II procollagen (COL2A1): variations in the nucleotide sequences of the alleles from three chromosomes.
Genomics 1990;8(3):454-60.
1990: Zafarullah K; Kleinert C; Tromp G; Kuivaniemi H; Kontusaari S; Wu Y L; Ganguly A; Prockop D J
G to A polymorphism in exon 31 of the COL3A1 gene.
Nucleic acids research 1990;18(20):6180.
1990: Constantinou C D; Pack M; Young S B; Prockop D J
Phenotypic heterogeneity in osteogenesis imperfecta: the mildly affected mother of a proband with a lethal variant has the same mutation substituting cysteine for alpha 1-glycine 904 in a type I procollagen gene (COL1A1).
American journal of human genetics 1990;47(4):670-9.
1990: Ala-Kokko L; Prockop D J
Efficient procedure for preparing cosmid libraries from microgram quantities of genomic DNA fragments size fractionated by gel electrophoresis.
Matrix (Stuttgart, Germany) 1990;10(5):279-84.
1990: Prockop D J
Mutations that alter the primary structure of type I collagen. The perils of a system for generating large structures by the principle of nucleated growth.
The Journal of biological chemistry 1990;265(26):15349-52.
1990: Constantinou C D; Spotila L D; Zhuang J; Sereda L; Hanning C; Prockop D J
PvuII polymorphism at the COL1A2 locus.
Nucleic acids research 1990;18(18):5577.
1990: Ala-Kokko L; Baldwin C T; Moskowitz R W; Prockop D J
Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6565-8.
1990: Westerhausen A; Kishi J; Prockop D J
Mutations that substitute serine for glycine alpha 1-598 and glycine alpha 1-631 in type I procollagen. The effects on thermal unfolding of the triple helix are position-specific and demonstrate that the protein unfolds through a series of cooperative blocks.
The Journal of biological chemistry 1990;265(23):13995-4000.
1990: Westerhausen A I; Constantinou C D; Prockop D J
A sequence polymorphism in the 3'-nontranslated region of the pro alpha 1 chain of type I procollagen.
Nucleic acids research 1990;18(16):4968.
1990: Ganguly A; Prockop D J
Detection of single-base mutations by reaction of DNA heteroduplexes with a water-soluble carbodiimide followed by primer extension: application to products from the polymerase chain reaction.
Nucleic acids research 1990;18(13):3933-9.
1990: Kuivaniemi H; Kontusaari S; Tromp G; Zhao M J; Sabol C; Prockop D J
Identical G+1 to A mutations in three different introns of the type III procollagen gene (COL3A1) produce different patterns of RNA splicing in three variants of Ehlers-Danlos syndrome. IV. An explanation for exon skipping some mutations and not others.
The Journal of biological chemistry 1990;265(20):12067-74.
1990: Kontusaari S; Tromp G; Kuivaniemi H; Ladda R L; Prockop D J
Inheritance of an RNA splicing mutation (G+ 1 IVS20) in the type III procollagen gene (COL3A1) in a family having aortic aneurysms and easy bruisability: phenotypic overlap between familial arterial aneurysms and Ehlers-Danlos syndrome type IV.
American journal of human genetics 1990;47(1):112-20.
1990: Kadler K E; Hojima Y; Prockop D J
Collagen fibrils in vitro grow from pointed tips in the C- to N-terminal direction.
The Biochemical journal 1990;268(2):339-43.
1990: Knowlton R G; Katzenstein P L; Moskowitz R W; Weaver E J; Malemud C J; Pathria M N; Jimenez S A; Prockop D J
Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chondrodysplasia.
The New England journal of medicine 1990;322(8):526-30.
1990: Prockop D J; Olsen A; Kontusaari S; Hyland J; Ala-Kokko L; Vasan N S; Barton E; Buck S; Harrison K; Brent R L
Mutations in human procollagen genes. Consequences of the mutations in man and in transgenic mice.
Annals of the New York Academy of Sciences 1990;580():330-9.
1990: Kadler K E; Hulmes D J; Hojima Y; Prockop D J
Assembly of type I collagen fibrils de novo by the specific enzymic cleavage of pC collagen. The fibrils formed at about 37 degrees C are similar in diameter, roundness, and apparent flexibility to the collagen fibrils seen in connective tissue.
Annals of the New York Academy of Sciences 1990;580():214-24.
1990: Prockop D J; Baldwin C T; Constantinou C D
Mutations in type I procollagen genes that cause osteogenesis imperfecta.
Advances in human genetics 1990;19():105-32.
1990: Tryggvason K; Soininen R; Hostikka S L; Ganguly A; Huotari M; Prockop D J
Structure of the human type IV collagen genes.
Annals of the New York Academy of Sciences 1990;580():97-111.
1989: Tromp G; Kuivaniemi H; Stolle C; Pope F M; Prockop D J
Single base mutation in the type III procollagen gene that converts the codon for glycine 883 to aspartate in a mild variant of Ehlers-Danlos syndrome IV.
The Journal of biological chemistry 1989;264(32):19313-7.
1989: Knowlton R G; Weaver E J; Struyk A F; Knobloch W H; King R A; Norris K; Shamban A; Uitto J; Jimenez S A; Prockop D J
Genetic linkage analysis of hereditary arthro-ophthalmopathy (Stickler syndrome) and the type II procollagen gene.
American journal of human genetics 1989;45(5):681-8.
1989: Pack M; Constantinou C D; Kalia K; Nielsen K B; Prockop D J
Substitution of serine for alpha 1(I)-glycine 844 in a severe variant of osteogenesis imperfecta minimally destabilizes the triple helix of type I procollagen. The effects of glycine substitutions on thermal stability are either position of amino acid specific.
The Journal of biological chemistry 1989;264(33):19694-9.
1989: Baldwin C T; Reginato A M; Smith C; Jimenez S A; Prockop D J
Structure of cDNA clones coding for human type II procollagen. The alpha 1(II) chain is more similar to the alpha 1(I) chain than two other alpha chains of fibrillar collagens.
The Biochemical journal 1989;262(2):521-8.
1989: Baldwin C T; Reginato A M; Prockop D J
A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain.
The Journal of biological chemistry 1989;264(27):15747-50.
1989: Prockop D J; Constantinou C D; Dombrowski K E; Hojima Y; Kadler K E; Kuivaniemi H; Tromp G; Vogel B E
Type I procollagen: the gene-protein system that harbors most of the mutations causing osteogenesis imperfecta and probably more common heritable disorders of connective tissue.
American journal of medical genetics 1989;34(1):60-7.
1989: Soininen R; Huotari M; Ganguly A; Prockop D J; Tryggvason K
Structural organization of the gene for the alpha 1 chain of human type IV collagen.
The Journal of biological chemistry 1989;264(23):13565-71.
1989: Dombrowski K E; Vogel B E; Prockop D J
Mutations that alter the primary structure of type I procollagen have long-range effects on its cleavage by procollagen N-proteinase.
Biochemistry 1989;28(17):7107-12.
1989: Hojima Y; McKenzie J A; van der Rest M; Prockop D J
Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides.
The Journal of biological chemistry 1989;264(19):11336-45.
1989: Ala-Kokko L; Kontusaari S; Baldwin C T; Kuivaniemi H; Prockop D J
Structure of cDNA clones coding for the entire prepro alpha 1 (III) chain of human type III procollagen. Differences in protein structure from type I procollagen and conservation of codon preferences.
The Biochemical journal 1989;260(2):509-16.
1989: Ganguly A; Rooney J E; Hosomi S; Zeiger A R; Prockop D J
Detection and location of single-base mutations in large DNA fragments by immunomicroscopy.
Genomics 1989;4(4):530-8.
1989: Olsen A S; Prockop D J
Transcription of human type I collagen genes. Variation in the relative rates of transcription of the pro alpha 1 and pro alpha 2 genes.
Matrix (Stuttgart, Germany) 1989;9(2):73-81.
1989: Baldwin C T; Constantinou C D; Dumars K W; Prockop D J
A single base mutation that converts glycine 907 of the alpha 2(I) chain of type I procollagen to aspartate in a lethal variant of osteogenesis imperfecta. The single amino acid substitution near the carboxyl terminus destabilizes the whole triple helix.
The Journal of biological chemistry 1989;264(5):3002-6.
1989: Constantinou C D; Nielsen K B; Prockop D J
A lethal variant of osteogenesis imperfecta has a single base mutation that substitutes cysteine for glycine 904 of the alpha 1(I) chain of type I procollagen. The asymptomatic mother has an unidentified mutation producing an overmodified and unstable type I procollagen.
The Journal of clinical investigation 1989;83(2):574-84.
1989: Pihlajaniemi T; McKeon J; Gay S; Gay R; de Wet W J; Myers J C; Prockop D J
Increased expression of the gene for the pro alpha 1(IV) chain of basement-membrane procollagen in cultured skin fibroblasts from two variants of osteogenesis imperfecta.
The Biochemical journal 1989;257(2):439-45.
1989: Tromp G; Kuivaniemi H; Shikata H; Prockop D J
A single base mutation that substitutes serine for glycine 790 of the alpha 1 (III) chain of type III procollagen exposes an arginine and causes Ehlers-Danlos syndrome IV.
The Journal of biological chemistry 1989;264(3):1349-52.
1989: Prockop D J
The Gordon Wilson lecture. Mutations in type I procollagen genes. An explanation for brittle bones and a paradigm for other diseases of connective tissue.
Transactions of the American Clinical and Climatological Association 1989;100():70-80.
1988: Vogel B E; Doelz R; Kadler K E; Hojima Y; Engel J; Prockop D J
A substitution of cysteine for glycine 748 of the alpha 1 chain produces a kink at this site in the procollagen I molecule and an altered N-proteinase cleavage site over 225 nm away.
The Journal of biological chemistry 1988;263(35):19249-55.
1988: Soininen R; Huotari M; Hostikka S L; Prockop D J; Tryggvason K
The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.
The Journal of biological chemistry 1988;263(33):17217-20.
1988: Dombrowski K E; Prockop D J
Cleavage of type I and type II procollagens by type I/II procollagen N-proteinase. Correlation of kinetic constants with the predicted conformations of procollagen substrates.
The Journal of biological chemistry 1988;263(32):16545-52.
1988: Tikka L; Pihlajaniemi T; Henttu P; Prockop D J; Tryggvason K
Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7491-5.
1988: Kuivaniemi H; Sabol C; Tromp G; Sippola-Thiele M; Prockop D J
A 19-base pair deletion in the pro-alpha 2(I) gene of type I procollagen that causes in-frame RNA splicing from exon 10 to exon 12 in a proband with atypical osteogenesis imperfecta and in his asymptomatic mother.
The Journal of biological chemistry 1988;263(23):11407-13.
1988: Tromp G; Kuivaniemi H; Stacey A; Shikata H; Baldwin C T; Jaenisch R; Prockop D J
Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen.
The Biochemical journal 1988;253(3):919-22.
1988: Kadler K E; Hojima Y; Prockop D J
Assembly of type I collagen fibrils de novo. Between 37 and 41 degrees C the process is limited by micro-unfolding of monomers.
The Journal of biological chemistry 1988;263(21):10517-23.
1988: Tromp G; Prockop D J
Single base mutation in the pro alpha 2(I) collagen gene that causes efficient splicing of RNA from exon 27 to exon 29 and synthesis of a shortened but in-frame pro alpha 2(I) chain.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5254-8.
1988: Poulsom R; Kurkinen M; Prockop D J; Boot-Handford R P
Increased steady-state levels of laminin B1 mRNA in kidneys of long-term streptozotocin-diabetic rats. No effect of an aldose reductase inhibitor.
The Journal of biological chemistry 1988;263(21):10072-6.
1988: Kuivaniemi H; Tromp G; Chu M L; Prockop D J
Structure of a full-length cDNA clone for the prepro alpha 2(I) chain of human type I procollagen. Comparison with the chicken gene confirms unusual patterns of gene conservation.
The Biochemical journal 1988;252(3):633-40.
1988: Prockop D J
Osteogenesis imperfecta. A model for genetic causes of osteoporosis and perhaps several other common diseases of connective tissue.
Arthritis and rheumatism 1988;31(1):1-8.
1988: Prockop D J; Kadler K E; Hojima Y; Constantinou C D; Dombrowski K E; Kuivaniemi H; Tromp G; Vogel B
Expression of type I procollagen genes.
Ciba Foundation symposium 1988;136():142-60.
1987: Soininen R; Haka-Risku T; Prockop D J; Tryggvason K
Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen.
FEBS letters 1987;225(1-2):188-94.
1987: Kadler K E; Hojima Y; Prockop D J
Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process.
The Journal of biological chemistry 1987;262(32):15696-701.
1987: Vogel B E; Minor R R; Freund M; Prockop D J
A point mutation in a type I procollagen gene converts glycine 748 of the alpha 1 chain to cysteine and destabilizes the triple helix in a lethal variant of osteogenesis imperfecta.
The Journal of biological chemistry 1987;262(30):14737-44.
1987: Tikka L; Roiko K; Soininen R; Prockop D J; Tryggvason K
A HindIII polymorphism in the 3' end of the human alpha 1(IV) collagen gene.
Nucleic acids research 1987;15(13):5497.
1987: Constantinou C D; Vogel B E; Jeffrey J J; Prockop D J
The A and B fragments of normal type I procollagen have a similar thermal stability to proteinase digestion but are selectively destabilized by structural mutations.
European journal of biochemistry / FEBS 1987;163(2):247-51.
1987: Minor R R; Wootton J A; Prockop D J; Patterson D F
Genetic diseases of connective tissues in animals.
Current problems in dermatology 1987;17():199-215.
1986: Soininen R; Chow L; Kurkinen M; Tryggvason K; Prockop D J
The gene for the alpha 1(IV) chain of human type IV procollagen: the exon structures do not coincide with the two structural subdomains in the globular carboxy-terminus of the protein.
The EMBO journal 1986;5(11):2821-3.
1986: Soininen R; Tikka L; Chow L; Pihlajaniemi T; Kurkinen M; Prockop D J; Boyd C D; Tryggvason K
Large introns in the 3' end of the gene for the pro alpha 1 (IV) chain of human basement membrane collagen.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1568-72.
1985: Prockop D J; Chu M L; de Wet W; Myers J C; Pihlajaniemi T; Ramirez F; Sippola M
Mutations in osteogenesis imperfecta leading to the synthesis of abnormal type I procollagens.
Annals of the New York Academy of Sciences 1985;460():289-97.

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