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Peter Proks

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Patch-Clamp Techniques

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Diabetes Mellitus

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All Publications

2010: Peter Proks; Heidi de Wet; Frances M Ashcroft
Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.
The Journal of general physiology 2010;136(4):389-405.
2010: Rebecca Clark; Peter Proks
ATP-sensitive potassium channels in health and disease.
Advances in experimental medicine and biology 2010;654():165-92.
2009: Peter Proks; Frances M Ashcroft
Modeling K(ATP) channel gating and its regulation.
Progress in biophysics and molecular biology 2009;99(1):7-19.
2008: Mayumi Negishi; Kenju Shimomura; Peter Proks; Yohnosuke Shimomura; Masatomo Mori
Alpha glucosidase inhibitor voglibose can prevent pioglitazone-induced body weight gain in Type 2 diabetic patients.
British journal of clinical pharmacology 2008;66(2):318-9.
2008: Tim J Craig; Frances M Ashcroft; Peter Proks
How ATP inhibits the open K(ATP) channel.
The Journal of general physiology 2008;132(1):131-44.
2008: Heidi de Wet; Peter Proks; Mathilde Lafond; Jussi Aittoniemi; Mark S P Sansom; Sarah Flanagan; Ewan R Pearson; Andrew T Hattersley; Frances M Ashcroft
A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes.
EMBO reports 2008;9(7):648-54.
2008: Paolo Tammaro; Kenju Shimomura; Peter Proks
Xenopus oocytes as a heterologous expression system for studying ion channels with the patch-clamp technique.
Methods in molecular biology (Clifton, N.J.) 2008;491():127-39.
2008: Julian P H Shield; Sarah Flanagan; Deborah J G Mackay; Lorna W Harries; Peter Proks; Christophe Girard; Frances M Ashcroft; I Karen Temple; Sian Ellard
Mosaic paternal uniparental isodisomy and an ABCC8 gene mutation in a patient with permanent neonatal diabetes and hemihypertrophy.
Diabetes 2008;57(1):255-8.
2007: Peter Proks; Kenju Shimomura; Tim J Craig; Christophe Girard; Frances M Ashcroft
Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome.
Human molecular genetics 2007;16(16):2011-9.
2007: Sian Ellard; Sarah Flanagan; Christophe Girard; Ann-Marie Patch; Lorna W Harries; Andrew Parrish; Emma L Edghill; Deborah J G Mackay; Peter Proks; Kenju Shimomura; Holger Haberland; Dennis J Carson; Julian P H Shield; Andrew T Hattersley; Frances M Ashcroft
Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects.
American journal of human genetics 2007;81(2):375-82.
2006: Kenju Shimomura; M Ikeda; Y Ariyama; Peter Proks; Y Shimomura; M Mori; S Matsumoto
Effect of peroxisome proliferator-activated receptor alpha ligand fenofibrate on K(v) channels in the insulin-secreting cell line HIT-T15.
General physiology and biophysics 2006;25(4):455-60.
2006: Christophe Girard; Kenju Shimomura; Peter Proks; Nathan Absalom; Luis Castano; Guiomar Perez de Nanclares; Frances M Ashcroft
Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.
Pflügers Archiv : European journal of physiology 2006;453(3):323-32.
2006: Peter Proks; Christophe Girard; Halvor Baevre; Pål R Njølstad; Frances M Ashcroft
Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy.
Diabetes 2006;55(6):1731-7.
2006: Kenju Shimomura; Christophe Girard; Peter Proks; Joanna Nazim; Jonathan D Lippiat; Franco Cerutti; Renata Lorini; Sian Ellard; Andrew T Hattersley; Fabrizio Barbetti; Frances M Ashcroft
Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.
Diabetes 2006;55(6):1705-12.
2006: Peter Proks; Amanda L Arnold; Jan Bruining; Christophe Girard; Sarah Flanagan; Brian Larkin; Kevin Colclough; Andrew T Hattersley; Frances M Ashcroft; Sian Ellard
A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.
Human molecular genetics 2006;15(11):1793-800.
2006: Paolo Tammaro; Peter Proks; Frances M Ashcroft
Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels.
The Journal of physiology 2006;571(Pt 1):3-14.
2006: Peter Proks; Jonathan D Lippiat
Membrane ion channels and diabetes.
Current pharmaceutical design 2006;12(4):485-501.
2005: Peter Proks; Christophe Girard; Frances M Ashcroft
Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.
Human molecular genetics 2005;14(18):2717-26.
2005: haider shozeb; Jennifer F Antcliff; Peter Proks; Mark S P Sansom; Frances M Ashcroft
Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.
Journal of molecular and cellular cardiology 2005;38(6):927-36.
2005: Peter Proks; Christophe Girard; haider shozeb; Anna L Gloyn; Andrew T Hattersley; Mark S P Sansom; Frances M Ashcroft
A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome.
EMBO reports 2005;6(5):470-5.
2005: Ayo TOYE; Jonathan D Lippiat; Peter Proks; Kenju Shimomura; Liz Bentley; Alison Hugill; V Mijat; Michelle Goldsworthy; Lee Moir; Alison Haynes; J Quarterman; H C Freeman; Frances M Ashcroft; Roger D Cox
A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.
Diabetologia 2005;48(4):675-86.
2005: Anna L Gloyn; Frank Reimann; Christophe Girard; Emma L Edghill; Peter Proks; Ewan R Pearson; I Karen Temple; Deborah J G Mackay; Julian P H Shield; Debra Freedenberg; Kathryn Noyes; Sian Ellard; Frances M Ashcroft; Fiona M Gribble; Andrew T Hattersley
Relapsing diabetes can result from moderately activating mutations in KCNJ11.
Human molecular genetics 2005;14(7):925-34.
2005: Jennifer F Antcliff; haider shozeb; Peter Proks; Mark S P Sansom; Frances M Ashcroft
Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.
The EMBO journal 2005;24(2):229-39.
2004: Peter Proks; Jennifer F Antcliff; Jonathan D Lippiat; Anna L Gloyn; Andrew T Hattersley; Frances M Ashcroft
Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17539-44.
2004: Jeff D Campbell; Peter Proks; Jonathan D Lippiat; Mark S P Sansom; Frances M Ashcroft
Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains.
Diabetes 2004;53 Suppl 3():S123-7.
2004: Shi-Bing Yang; Peter Proks; Frances M Ashcroft; Marjan Rupnik
Inhibition of ATP-sensitive potassium channels by haloperidol.
British journal of pharmacology 2004;143(8):960-7.
2004: Anna L Gloyn; Ewan R Pearson; Jennifer F Antcliff; Peter Proks; G Jan Bruining; Annabelle S Slingerland; Neville Howard; Shubha Srinivasan; José M C L Silva; Janne Molnes; Emma L Edghill; Timothy M Frayling; I Karen Temple; Deborah Mackay; Julian P H Shield; Zdenek Sumnik; Adrian van Rhijn; J K H Wales; Penny Clark; Shaun Gorman; Javier Aisenberg; Sian Ellard; Pål R Njølstad; Frances M Ashcroft; Andrew T Hattersley
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
The New England journal of medicine 2004;350(18):1838-49.
2003: Charlotte E Capener; Peter Proks; Frances M Ashcroft; Mark S P Sansom
Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.
Biophysical journal 2003;84(4):2345-56.
2003: Frank Reimann; Hanna Huopio; Michael Dabrowski; Peter Proks; Fiona M Gribble; Markku Laakso; Timo Otonkoski; Frances M Ashcroft
Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population.
Diabetologia 2003;46(2):241-9.
2003: Peter Proks; Jennifer F Antcliff; Frances M Ashcroft
The ligand-sensitive gate of a potassium channel lies close to the selectivity filter.
EMBO reports 2003;4(1):70-5.
2002: Peter Proks; Frank Reimann; Nick Green; Fiona M Gribble; Frances M Ashcroft
Sulfonylurea stimulation of insulin secretion.
Diabetes 2002;51 Suppl 3():S368-76.
2002: Peter Proks; Iris Treinies; Hans-Jürgen Mest; Stefan Trapp
Inhibition of recombinant K(ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382.
European journal of pharmacology 2002;452(1):11-9.
2001: Peter Proks; Charlotte E Capener; P Jones; Frances M Ashcroft
Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.
The Journal of general physiology 2001;118(4):341-53.
2001: Frank Reimann; Peter Proks; Frances M Ashcroft
Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
British journal of pharmacology 2001;132(7):1542-8.
2001: Peter Proks; Phillippa Jones; Frances M Ashcroft
Interaction of stilbene disulphonates with cloned K(ATP) channels.
British journal of pharmacology 2001;132(5):973-82.
2000: Kouichi Tanabe; Stephen J Tucker; FM Ashcroft; Peter Proks; Noriyuki Kioka; Teruo Amachi; Kunihiro Ueda
Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide.
Biochemical and biophysical research communications 2000;272(2):316-9.
1999: Peter Proks; R Ashfield; Frances M Ashcroft
Interaction of vanadate with the cloned beta cell K(ATP) channel.
The Journal of biological chemistry 1999;274(36):25393-7.
1999: Frank Reimann; Stephen J Tucker; Peter Proks; Frances M Ashcroft
Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.
The Journal of physiology 1999;518 ( Pt 2)():325-36.
1999: P A Smith; Peter Proks; A Moorhouse
Direct effects of tolbutamide on mitochondrial function, intracellular Ca2+ and exocytosis in pancreatic beta-cells.
Pflügers Archiv : European journal of physiology 1999;437(4):577-88.
1999: Kouichi Tanabe; Stephen J Tucker; Michinori Matsuo; Peter Proks; FM Ashcroft; Susumu Seino; Teruo Amachi; Kunihiro Ueda
Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP.
The Journal of biological chemistry 1999;274(7):3931-3.
1999: Peter Proks; Fiona M Gribble; R Adhikari; Stephen J Tucker; Frances M Ashcroft
Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.
The Journal of physiology 1999;514 ( Pt 1)():19-25.
1998: Fiona M Gribble; Peter Proks; Barbara E Corkey; Frances M Ashcroft
Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA.
The Journal of biological chemistry 1998;273(41):26383-7.
1998: Stefan Trapp; Peter Proks; Stephen J Tucker; Frances M Ashcroft
Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.
The Journal of general physiology 1998;112(3):333-49.
1998: Stephen J Tucker; Fiona M Gribble; Peter Proks; Stefan Trapp; T J Ryder; T Haug; Frank Reimann; Frances M Ashcroft
Molecular determinants of KATP channel inhibition by ATP.
The EMBO journal 1998;17(12):3290-6.
1997: Peter Proks; Frances M Ashcroft
Phentolamine block of KATP channels is mediated by Kir6.2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11716-20.
1996: Peter Proks; Lena Eliasson; C Ammälä; Patrik Rorsman; F M Ashcroft
Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps.
The Journal of physiology 1996;496 ( Pt 1)():255-64.
1996: Lena Eliasson; Peter Proks; C Ammälä; F M Ashcroft; Krister Bokvist; Erik Renström; Patrik Rorsman; P A Smith
Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium.
The Journal of physiology 1996;493 ( Pt 3)():755-67.
1996: C Ammälä; A Moorhouse; Fiona M Gribble; R Ashfield; Peter Proks; P A Smith; H Sakura; B Coles; Stephen J H Ashcroft; F M Ashcroft
Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels.
Nature 1996;379(6565):545-8.
1995: Peter Proks; F M Ashcroft
Effects of divalent cations on exocytosis and endocytosis from single mouse pancreatic beta-cells.
The Journal of physiology 1995;487 ( Pt 2)():465-77.
1995: Chris T Bond; C Ammälä; R Ashfield; T A Blair; Fiona M Gribble; Raheela N Khan; K Lee; Peter Proks; I C Rowe; H Sakura
Cloning and functional expression of the cDNA encoding an inwardly-rectifying potassium channel expressed in pancreatic beta-cells and in the brain.
FEBS letters 1995;367(1):61-6.
1994: F M Ashcroft; B Coles; S Kenna; Peter Proks; J Röper; J Reid; P A Smith; M Takano
The KATP and Kv channels are distinct entities: a reply to Edwards and Weston.
Cardiovascular research 1994;28(6):738-40; discussion 741-5.
1994: F M Ashcroft; Peter Proks; P A Smith; C Ammälä; Krister Bokvist; Patrik Rorsman
Stimulus-secretion coupling in pancreatic beta cells.
Journal of cellular biochemistry 1994;55 Suppl():54-65.
1993: Peter Proks; F M Ashcroft
Modification of K-ATP channels in pancreatic beta-cells by trypsin.
Pflügers Archiv : European journal of physiology 1993;424(1):63-72.