FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Eric Prossnitz

Research Profile

Chemicals & Drugs

Physiology

Co-author Network

Publications

TOP 3
Ryan L Brunsing; Kristin S Owens; Eric R Prossnitz
The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions.
Eric R Prossnitz
G protein-coupled estrogen receptor: a new therapeutic target in stroke and traumatic brain/spinal cord injury?
Matthias R Meyer; Matthias Barton; Angela S Field; Nancy L Kanagy; Eric R Prossnitz
GPER regulates endothelin-dependent vascular tone and intracellular calcium.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Eric Prossnitz (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Ryan L Brunsing; Kristin S Owens; Eric R Prossnitz
The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2013;36(3):190-6.
2012: Eric R Prossnitz
G protein-coupled estrogen receptor: a new therapeutic target in stroke and traumatic brain/spinal cord injury?
Critical care medicine 2012;40(12):3323-5.
2012: Matthias R Meyer; Matthias Barton; Angela S Field; Nancy L Kanagy; Eric R Prossnitz
GPER regulates endothelin-dependent vascular tone and intracellular calcium.
Life sciences 2012;91(13-14):623-7.
2012: Matthias Barton; Eric R Prossnitz; Matthias R Meyer
Testosterone and secondary hypertension: new pieces to the puzzle.
Hypertension 2012;59(6):1101-3.
2012: Matthias R Meyer; Mary K Walker; Kerstin Amann; Matthias Barton; Angela S Field; Helen J Hathaway; Chelin Hu; Nancy L Kanagy; Eric R Prossnitz
Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction.
Hypertension 2012;59(2):507-12.
2011: Eric R Prossnitz; Matthias Barton
The G-protein-coupled estrogen receptor GPER in health and disease.
Nature reviews. Endocrinology 2011;7(12):715-26.
2011: Xuan Yu; Scott A Barman; Alexander T Liu; Handong Ma; Eric R Prossnitz; Minga Sellers; John N Stallone; Richard E White; Guichun Han
Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle.
American journal of physiology. Endocrinology and metabolism 2011;301(5):E882-8.
2011: Megan K Dennis; Angela S Field; Helen J Hathaway; Shin-Ichi Hayashi; Tudor I Oprea; Whitney K Petrie; Jeffrey B Arterburn; Cristian Bologa; Ritwik Burai; Chinnasamy Ramesh; Larry A Sklar; Yuri Yamaguchi; Eric R Prossnitz
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity.
The Journal of steroid biochemistry and molecular biology 2011;127(3-5):358-66.
2011: Joseph P Glass; Gulshan Parasher; Eric R Prossnitz; Hugo Arias-Pulido; Rachel Donohue; Lisa A Cerilli
Mesothelin and GPR30 staining among a spectrum of pancreatic epithelial neoplasms.
International journal of surgical pathology 2011;19(5):588-96.
2011: Ryan L Brunsing; Eric R Prossnitz
Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1.
Immunology 2011;134(1):93-106.
2011: Haixun Guo; Helen Hathaway; Jie Lu; Eric R Prossnitz; Melanie E Royce; Yubin Miao
Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides.
Bioconjugate chemistry 2011;22(8):1682-9.
2011: Geetanjali Sharma; Eric R Prossnitz
Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells.
Endocrinology 2011;152(8):3030-9.
2011: Matthias R Meyer; Eric R Prossnitz; Matthias Barton
The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function.
Vascular pharmacology 2011;55(1-3):17-25.
2011: Matthias Barton; Matthias R Meyer; Eric R Prossnitz
Estrogen-independent activation of estrogen receptors.
Hypertension 2011;57(6):1056-7.
2011: Sarah H Lindsey; Kyle A Carver; Eric R Prossnitz; Mark Chappell
Vasodilation in response to the GPR30 agonist G-1 is not different from estradiol in the mRen2.Lewis female rat.
Journal of cardiovascular pharmacology 2011;57(5):598-603.
2011: Rinshi S Kasai; Kenichi G N Suzuki; Eric R Prossnitz; Ikuko Koyama-Honda; Chieko Nakada; Takahiro K Fujiwara; Akihiro Kusumi
Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging.
The Journal of cell biology 2011;192(3):463-80.
2010: John Kuo; Naheed Hamid; Galyna Bondar; Eric R Prossnitz; Paul Micevych
Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(39):12950-7.
2010: Gloria Huang; Marc Gunter; Rebecca C Arend; Maomi Li; Hugo Arias-Pulido; Eric R Prossnitz; Gary L Goldberg; Harriet O Smith
Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma.
American journal of obstetrics and gynecology 2010;203(3):242.e1-5.
2010: Hugo Arias-Pulido; Melanie Royce; Yun Gong; Nancy E Joste; Lesley Lomo; Sang-Joon Lee; Nabila Chaher; Claire F Verschraegen; Juanita Lara; Eric R Prossnitz; Massimo Cristofanilli
GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancer.
Breast cancer research and treatment 2010;123(1):51-8.
2010: Tapan K Nayak; Megan K Dennis; Chinnasamy Ramesh; Ritwik Burai; Robert W Atcher; Larry A Sklar; Jeffrey P Norenberg; Helen J Hathaway; Jeffrey B Arterburn; Eric R Prossnitz
Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents.
ACS chemical biology 2010;5(7):681-90.
2010: Gloria Huang; Jurriaan Brouwer-Visser; Marissa J Ramirez; Christine H Kim; Tiffany Hebert; Juan Lin; Hugo Arias-Pulido; Clifford R Qualls; Eric R Prossnitz; Gary L Goldberg; Harriet O Smith; Susan B. Horwitz
Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(11):2999-3010.
2010: Ritwik Burai; Chinnasamy Ramesh; Marvin Shorty; Ramona Curpan; Cristian Bologa; Larry A Sklar; Tudor I Oprea; Eric R Prossnitz; Jeffrey B Arterburn
Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs.
Organic & biomolecular chemistry 2010;8(9):2252-9.
2010: Chinnasamy Ramesh; Tapan K Nayak; Ritwik Burai; Megan K Dennis; Helen J Hathaway; Larry A Sklar; Eric R Prossnitz; Jeffrey B Arterburn
Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30.
Journal of medicinal chemistry 2010;53(3):1004-14.
2010: Eric A Ariazi; Eugen Brailoiu; Smitha Yerrum; Heather A Shupp; Michael J Slifker; Heather Cunliffe; Michael A Black; Anne L Donato; Jeffrey B Arterburn; Tudor I Oprea; Eric R Prossnitz; Nae J Dun; V Craig Jordan
The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.
Cancer research 2010;70(3):1184-94.
2010: Keiko Takanami; Hirotaka Sakamoto; Ken-Ichi Matsuda; Koji Hosokawa; Mayumi Nishi; Eric R Prossnitz; Mitsuhiro Kawata
Expression of G protein-coupled receptor 30 in the spinal somatosensory system.
Brain research 2010;1310():17-28.
2010: Matthias Barton; Matthias R Meyer; Judy L Bolton; Eric R Prossnitz
Lung cancer and hormone replacement therapy.
Lancet 2010;375(9709):117-8; author reply 118-9.
2010: Matthias R Meyer; Oliver Baretella; Eric R Prossnitz; Matthias Barton
Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780.
Pharmacology 2010;86(1):58-64.
2009: Haixun Guo; Jianquan Yang; Fabio Gallazzi; Eric R Prossnitz; Larry A Sklar; Yubin Miao
Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide.
Bioconjugate chemistry 2009;20(11):2162-8.
2009: Eric Blasko; Christopher A Haskell; Stewart Leung; Giovanna Gualtieri; Meredith Halks-Miller; Mithra Mahmoudi; Megan K Dennis; Eric R Prossnitz; William J Karpus; richard horuk
Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis.
Journal of neuroimmunology 2009;214(1-2):67-77.
2009: Matthias R Meyer; Elvira Haas; Eric R Prossnitz; Matthias Barton
Non-genomic regulation of vascular cell function and growth by estrogen.
Molecular and cellular endocrinology 2009;308(1-2):9-16.
2009: Eric R Prossnitz; Marcello Maggiolini
Mechanisms of estrogen signaling and gene expression via GPR30.
Molecular and cellular endocrinology 2009;308(1-2):32-8.
2009: Eric R Prossnitz; Marcello Maggiolini
Non-genomic signaling by steroids.
Molecular and cellular endocrinology 2009;308(1-2):1-2.
2009: Brant M Wagener; Nicole A Marjon; Chetana M Revankar; Eric R Prossnitz
Adaptor protein-2 interaction with arrestin regulates GPCR recycling and apoptosis.
Traffic (Copenhagen, Denmark) 2009;10(9):1286-300.
2009: Hugo Arias-Pulido; Harriet O Smith; Nancy E Joste; Therese Bocklage; Clifford R Qualls; Allison Chavez; Eric R Prossnitz; Claire F Verschraegen
Estrogen and progesterone receptor status and outcome in epithelial ovarian cancers and low malignant potential tumors.
Gynecologic oncology 2009;114(3):480-5.
2009: Harriet O Smith; Hugo Arias-Pulido; Dennis Kuo; Tamara Howard; Clifford R Qualls; Sang-Joon Lee; Claire F Verschraegen; Helen J Hathaway; Nancy E Joste; Eric R Prossnitz
GPR30 predicts poor survival for ovarian cancer.
Gynecologic oncology 2009;114(3):465-71.
2009: Eric R Prossnitz; Matthias Barton
Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER.
Prostaglandins & other lipid mediators 2009;89(3-4):89-97.
2009: Georgina G J Hazell; Song T Yao; James A Roper; Eric R Prossnitz; Anne-Marie O'Carroll; Stephen J Lolait
Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues.
The Journal of endocrinology 2009;202(2):223-36.
2009: Mark K Haynes; J Jacob Strouse; Anna Waller; Andrei Leitao; Ramona F Curpan; Cristian Bologa; Tudor I Oprea; Eric R Prossnitz; Bruce S Edwards; Larry A Sklar; Todd A Thompson
Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system.
Journal of biomolecular screening 2009;14(6):596-609.
2009: Megan K Dennis; Ritwik Burai; Chinnasamy Ramesh; Whitney K Petrie; Sara N Alcon; Tapan K Nayak; Cristian Bologa; Andrei Leitao; Eugen Brailoiu; Elena Deliu; Nae J Dun; Larry A Sklar; Helen J Hathaway; Jeffrey B Arterburn; Tudor I Oprea; Eric R Prossnitz
In vivo effects of a GPR30 antagonist.
Nature chemical biology 2009;5(6):421-7.
2009: Siok L Dun; G Cristina Brailoiu; Xin Gao; Eugen Brailoiu; Jeffrey B Arterburn; Eric R Prossnitz; Tudor I Oprea; Nae J Dun
Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia.
Journal of neuroscience research 2009;87(7):1610-9.
2009: J Jacob Strouse; Susan M Young; Hugh D Mitchell; Richard D Ye; Eric R Prossnitz; Larry A Sklar; Bruce S Edwards
A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(3):264-70.
2009: Susan M Young; Cristian M Bologa; Dan Fara; Bj K Bryant; Juan Jacob Strouse; Jeffrey B Arterburn; Richard D Ye; Tudor I Oprea; Eric R Prossnitz; Larry A Sklar; Bruce S Edwards
Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(3):253-63.
2009: Elvira Haas; Indranil Bhattacharya; Eugen Brailoiu; Marlen Damjanović; G Cristina Brailoiu; Xin Gao; Laurence Mueller-Guerre; Nicole A Marjon; André Gut; Roberta Minotti; Matthias R Meyer; Kerstin Amann; Emerita Ammann; Ana Perez-Dominguez; Michele Genoni; Deborah J Clegg; Nae J Dun; Thomas C Resta; Eric R Prossnitz; Matthias Barton
Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity.
Circulation research 2009;104(3):288-91.
2009: Jeffrey B Arterburn; Tudor I Oprea; Eric R Prossnitz; Bruce S Edwards; Larry A Sklar
Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30.
Current topics in medicinal chemistry 2009;9(13):1227-36.
2009: Bruce S Edwards; Susan M Young; Irena Ivnitsky-Steele; Richard D Ye; Eric R Prossnitz; Larry A Sklar
High-content screening: flow cytometry analysis.
Methods in molecular biology (Clifton, N.J.) 2009;486():151-65.
2008: Cheng Wang; Eric R Prossnitz; Shyamal K Roy
G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary.
Endocrinology 2008;149(9):4452-61.
2008: Kenichi Matsuda; Hirotaka Sakamoto; Hiroko Mori; Koji Hosokawa; Akeo Kawamura; Minoru Itose; Mayumi Nishi; Eric R Prossnitz; Mitsuhiro Kawata
Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation.
Neuroscience letters 2008;441(1):94-9.
2008: Tapan K Nayak; Robert Atcher; Eric R Prossnitz; Jeffrey P Norenberg
Enhancement of somatostatin-receptor-targeted (177)Lu-[DOTA(0)-Tyr(3)]-octreotide therapy by gemcitabine pretreatment-mediated receptor uptake, up-regulation and cell cycle modulation.
Nuclear medicine and biology 2008;35(6):673-8.
2008: Jian Teng; Zun-Yi Wang; Eric R Prossnitz; Dale E Bjorling
The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation.
Endocrinology 2008;149(8):4024-34.
2008: Tapan K Nayak; Helen J Hathaway; Chinnasamy Ramesh; Jeffrey B Arterburn; Donghai Dai; Larry A Sklar; Jeffrey P Norenberg; Eric R Prossnitz
Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(6):978-86.
2008: Megan K Dennis; Harmony J C Bowles; Debra A MacKenzie; Scott W Burchiel; Bruce S Edwards; Larry A Sklar; Eric R Prossnitz; Todd A Thompson
A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(5):390-9.
2008: Eric R Prossnitz; Tudor I Oprea; Larry A Sklar; Jeffrey B Arterburn
The ins and outs of GPR30: a transmembrane estrogen receptor.
The Journal of steroid biochemistry and molecular biology 2008;109(3-5):350-3.
2008: Eric R Prossnitz; Larry A Sklar; Tudor I Oprea; Jeffrey B Arterburn
GPR30: a novel therapeutic target in estrogen-related disease.
Trends in pharmacological sciences 2008;29(3):116-23.
2008: Eric R Prossnitz; Jeffrey B Arterburn; Harriet O Smith; Tudor I Oprea; Larry A Sklar; Helen J Hathaway
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.
Annual review of physiology 2008;70():165-90.
2007: Yang Wu; Tione Buranda; Peter C Simons; Gabriel P Lopez; William E McIntire; James C Garrison; Eric R Prossnitz; Larry A Sklar
Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides.
Analytical biochemistry 2007;371(1):10-20.
2007: Hirotaka Sakamoto; Ken-ichi Matsuda; Koji Hosokawa; Mayumi Nishi; John F Morris; Eric R Prossnitz; Mitsuhiro Kawata
Expression of G protein-coupled receptor-30, a G protein-coupled membrane estrogen receptor, in oxytocin neurons of the rat paraventricular and supraoptic nuclei.
Endocrinology 2007;148(12):5842-50.
2007: Cheng Wang; Eric R Prossnitz; Shyamal K Roy
Expression of G protein-coupled receptor 30 in the hamster ovary: differential regulation by gonadotropins and steroid hormones.
Endocrinology 2007;148(10):4853-64.
2007: Chetana M Revankar; Hugh D Mitchell; Angela S Field; Ritwik Burai; Cesear Corona; Chinnasamy Ramesh; Larry A Sklar; Jeffrey B Arterburn; Eric R Prossnitz
Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30.
ACS chemical biology 2007;2(8):536-44.
2007: Bruce S Edwards; Steven W Graves; Tudor I Oprea; Eric R Prossnitz; Matthew J Saunders; Richard D Ye; Susan M Young; Cristian Bologa; Larry A Sklar
High-throughput flow cytometry for drug discovery.
Expert opinion on drug discovery 2007;2(5):685-96.
2007: Eugen Brailoiu; Siok L Dun; G Cristina Brailoiu; Keisuke Mizuo; Larry A Sklar; Tudor I Oprea; Eric R Prossnitz; Nae J Dun
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system.
The Journal of endocrinology 2007;193(2):311-21.
2007: Harriet O Smith; Kimberly K Leslie; Meenakshi Singh; Clifford R Qualls; Chetana M Revankar; Nancy E Joste; Eric R Prossnitz
GPR30: a novel indicator of poor survival for endometrial carcinoma.
American journal of obstetrics and gynecology 2007;196(4):386.e1-9; discussion 386.e9-11.
2007: Mei Xue; Genie Hsieh; Mary Ann Raymond-Stintz; Janet R Pfeiffer; Diana Roberts; Stanly L Steinberg; Janet M Oliver; Eric R Prossnitz; Diane S Lidke; Bridget S Wilson
Activated N-formyl peptide receptor and high-affinity IgE receptor occupy common domains for signaling and internalization.
Molecular biology of the cell 2007;18(4):1410-20.
2007: Lidia Albanito; Antonio Madeo; Rosamaria Lappano; Adele Vivacqua; Vittoria Rago; Amalia Carpino; Tudor I Oprea; Eric R Prossnitz; Anna Maria Musti; Sebastiano Andò; Marcello Maggiolini
G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells.
Cancer research 2007;67(4):1859-66.
2007: Tapan K Nayak; Jeffrey P Norenberg; Tamara L Anderson; Eric R Prossnitz; Michael G Stabin; Robert Atcher
Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cells.
Nuclear medicine and biology 2007;34(2):185-93.
2007: Eric R Prossnitz; Jeffrey B Arterburn; Larry A Sklar
GPR30: A G protein-coupled receptor for estrogen.
Molecular and cellular endocrinology 2007;265-266():138-42.
2007: Tione Buranda; Anna Waller; Yang Wu; Peter C Simons; Sean M Biggs; Eric R Prossnitz; Larry A Sklar
Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads.
Advances in protein chemistry 2007;74():95-135.
2006: Chinnasamy Ramesh; Bj Bryant; Tapan K Nayak; Chetana M Revankar; Tamara Anderson; Kathryn E Carlson; John A Katzenellenbogen; Larry A Sklar; Jeffrey P Norenberg; Eric R Prossnitz; Jeffrey B Arterburn
Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates.
Journal of the American Chemical Society 2006;128(45):14476-7.
2006: Eric R Prossnitz; Larry A Sklar; Jeffrey B Arterburn; Bruce S Edwards; Tudor I Oprea
Steroid-binding G-protein-coupled receptors: new drug discovery targets for old ligands.
Expert opinion on drug discovery 2006;1(2):137-50.
2006: Ayako Makino; Eric R Prossnitz; Moritz Bünemann; Ji Ming Wang; Weijuan Yao; Geert W Schmid-Schönbein
G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils.
American journal of physiology. Cell physiology 2006;290(6):C1633-9.
2006: Ross M Potter; Diane C Maestas; Daniel F Cimino; Eric R Prossnitz
Regulation of N-formyl peptide receptor signaling and trafficking by individual carboxyl-terminal serine and threonine residues.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5418-25.
2006: Mathewos Tessema; Peter C Simons; Daniel F Cimino; Lilliana Sanchez; Anna Waller; Richard G Posner; Angela Wandinger-Ness; Eric R Prossnitz; Larry A Sklar
Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(5):326-34.
2006: Cristian Bologa; Chetana M Revankar; Susan M Young; Bruce S Edwards; Jeffrey B Arterburn; Alexander S Kiselyov; Matthew A Parker; Sergey E Tkachenko; Nikolay P Savchuck; Larry A Sklar; Tudor I Oprea; Eric R Prossnitz
Virtual and biomolecular screening converge on a selective agonist for GPR30.
Nature chemical biology 2006;2(4):207-12.
2006: Ilya Okun; Sergei Malarchuk; Elena Dubrovskaya; Alexander Khvat; Sergey E Tkachenko; Volodymyr Kysil; Alexey Ilyin; Dmitry Kravchenko; Eric R Prossnitz; Larry A Sklar; Alexandre V Ivachtchenko
Screening for caspase-3 inhibitors: a new class of potent small-molecule inhibitors of caspase-3.
Journal of biomolecular screening 2006;11(3):277-85.
2006: Eric R Prossnitz; Larry A Sklar
Modulation of GPCR conformations by ligands, G-proteins, and arrestins.
Ernst Schering Foundation symposium proceedings 2006;(2):211-28.
2006: Bruce S Edwards; Susan M Young; Tudor I Oprea; Cristian Bologa; Eric R Prossnitz; Larry A Sklar
Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform.
Nature protocols 2006;1(1):59-66.
2005: Bruce S Edwards; Cristian Bologa; Susan M Young; Konstantin V Balakin; Eric R Prossnitz; Nikolay P Savchuck; Larry A Sklar; Tudor I Oprea
Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists.
Molecular pharmacology 2005;68(5):1301-10.
2005: Jennifer M Carter; Vsevolod V Gurevich; Eric R Prossnitz; John R Engen
Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry.
Journal of molecular biology 2005;351(4):865-78.
2005: Tudor I Oprea; Cristian Bologa; Bruce S Edwards; Eric R Prossnitz; Larry A Sklar
Post-high-throughput screening analysis: an empirical compound prioritization scheme.
Journal of biomolecular screening 2005;10(5):419-26.
2005: Susan M Young; Cristian Bologa; Eric R Prossnitz; Tudor I Oprea; Larry A Sklar; Bruce S Edwards
High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands.
Journal of biomolecular screening 2005;10(4):374-82.
2005: Chetana M Revankar; Daniel F Cimino; Larry A Sklar; Jeffrey B Arterburn; Eric R Prossnitz
A transmembrane intracellular estrogen receptor mediates rapid cell signaling.
Science (New York, N.Y.) 2005;307(5715):1625-30.
2005: T Alexander Key; Charlotte Vines; Brant M Wagener; Vsevolod V Gurevich; Larry A Sklar; Eric R Prossnitz
Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins.
Traffic (Copenhagen, Denmark) 2005;6(2):87-99.
2004: Anna Waller; Peter C Simons; Sean M Biggs; Bruce S Edwards; Eric R Prossnitz; Larry A Sklar
Techniques: GPCR assembly, pharmacology and screening by flow cytometry.
Trends in pharmacological sciences 2004;25(12):663-9.
2004: Mei Xue; Charlotte Vines; Tione Buranda; Daniel F Cimino; Teresa A Bennett; Eric R Prossnitz
N-formyl peptide receptors cluster in an active raft-associated state prior to phosphorylation.
The Journal of biological chemistry 2004;279(43):45175-84.
2004: Bruce S Edwards; Tudor I Oprea; Eric R Prossnitz; Larry A Sklar
Flow cytometry for high-throughput, high-content screening.
Current opinion in chemical biology 2004;8(4):392-8.
2004: Alexandre Chigaev; Gordon Zwartz; Tione Buranda; Bruce S Edwards; Eric R Prossnitz; Larry A Sklar
Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation.
The Journal of biological chemistry 2004;279(31):32435-43.
2004: Eric R Prossnitz
Novel roles for arrestins in the post-endocytic trafficking of G protein-coupled receptors.
Life sciences 2004;75(8):893-9.
2004: Charlotte Vines; Eric R Prossnitz
Mechanisms of G protein-coupled receptor-mediated degranulation.
FEMS microbiology letters 2004;236(1):1-6.
2004: Chetana M Revankar; Charlotte Vines; Daniel F Cimino; Eric R Prossnitz
Arrestins block G protein-coupled receptor-mediated apoptosis.
The Journal of biological chemistry 2004;279(23):24578-84.
2004: Bent Postma; Miriam J J G Poppelier; Joost van Galen; Eric R Prossnitz; Jos van Strijp; Carla J C de Haas; Kok P M van Kessel
Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):6994-7001.
2004: Peter C Simons; Sean M Biggs; Anna Waller; Terry D Foutz; Daniel F Cimino; Qing Guo; Richard Neubig; Wei-Jen Tang; Eric R Prossnitz; Larry A Sklar
Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction.
The Journal of biological chemistry 2004;279(14):13514-21.
2004: Susan M Young; Mark S Curry; John T Ransom; Juan A Ballesteros; Eric R Prossnitz; Larry A Sklar; Bruce S Edwards
High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening.
Journal of biomolecular screening 2004;9(2):103-11.
2003: Alexandre Chigaev; Tione Buranda; Denise C Dwyer; Eric R Prossnitz; Larry A Sklar
FRET detection of cellular alpha4-integrin conformational activation.
Biophysical journal 2003;85(6):3951-62.
2003: Peter C Simons; Mei Shi; Terry D Foutz; Daniel F Cimino; Jeremy Lewis; Tione Buranda; William K Lim; Richard Neubig; William E McIntire; James C Garrison; Eric R Prossnitz; Larry A Sklar
Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry.
Molecular pharmacology 2003;64(5):1227-38.
2003: Charlotte Vines; Chetana M Revankar; Diane C Maestas; Leah L LaRusch; Daniel F Cimino; Trudy A Kohout; Robert J Lefkowitz; Eric R Prossnitz
N-formyl peptide receptors internalize but do not recycle in the absence of arrestins.
The Journal of biological chemistry 2003;278(43):41581-4.
2003: Alexandre Chigaev; Gordon Zwartz; Steven W Graves; Denise C Dwyer; Hisashi Tsuji; Terry D Foutz; Bruce S Edwards; Eric R Prossnitz; Richard Larson; Larry A Sklar
Alpha4beta1 integrin affinity changes govern cell adhesion.
The Journal of biological chemistry 2003;278(40):38174-82.
2003: Mei Shi; Teresa A Bennett; Daniel F Cimino; Diane C Maestas; Terry D Foutz; Vsevolod V Gurevich; Larry A Sklar; Eric R Prossnitz
Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins.
Biochemistry 2003;42(24):7283-93.
2003: Anna Waller; Peter C Simons; Eric R Prossnitz; Bruce S Edwards; Larry A Sklar
High throughput screening of G-protein coupled receptors via flow cytometry.
Combinatorial chemistry & high throughput screening 2003;6(4):389-97.
2003: Eric R Prossnitz
Chemokines and chemokine receptors--Keystone Symposium 7-12 January 2003, Breckenridge, CO, USA.
IDrugs : the investigational drugs journal 2003;6(3):191-4.
2003: T Alexander Key; Terry D Foutz; Vsevolod V Gurevich; Larry A Sklar; Eric R Prossnitz
N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity.
The Journal of biological chemistry 2003;278(6):4041-7.
2002: Charlotte Vines; Mei Xue; Diane C Maestas; Daniel F Cimino; Eric R Prossnitz
Regulation of N-formyl peptide-mediated degranulation by receptor phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):6760-6.
2002: W Coyt Jackson; Teresa A Bennett; Bruce S Edwards; Eric R Prossnitz; Gabriel P Lopez; Larry A Sklar
Performance of in-line microfluidic mixers in laminar flow for high-throughput flow cytometry.
BioTechniques 2002;33(1):220-6.
2002: Timothy E Graham; Eric R Prossnitz; Richard I Dorin
Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases.
The Journal of biological chemistry 2002;277(13):10876-82.
2002: Ross M Potter; T Alexander Key; Vsevolod V Gurevich; Larry A Sklar; Eric R Prossnitz
Arrestin variants display differential binding characteristics for the phosphorylated N-formyl peptide receptor carboxyl terminus.
The Journal of biological chemistry 2002;277(11):8970-8.
2002: Larry A Sklar; Bruce S Edwards; Steven W Graves; John P Nolan; Eric R Prossnitz
Flow cytometric analysis of ligand-receptor interactions and molecular assemblies.
Annual review of biophysics and biomolecular structure 2002;31():97-119.
2001: Alexandre Chigaev; A M Blenc; J V Braaten; N Kumaraswamy; Christopher L Kepley; Ronald P Andrews; Janet M Oliver; Bruce S Edwards; Eric R Prossnitz; Richard Larson; Larry A Sklar
Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation.
The Journal of biological chemistry 2001;276(52):48670-8.
2001: Teresa A Bennett; Terry D Foutz; Vsevolod V Gurevich; Larry A Sklar; Eric R Prossnitz
Partial phosphorylation of the N-formyl peptide receptor inhibits G protein association independent of arrestin binding.
The Journal of biological chemistry 2001;276(52):49195-203.
2001: T Alexander Key; Teresa A Bennett; Terry D Foutz; Vsevolod V Gurevich; Larry A Sklar; Eric R Prossnitz
Regulation of formyl peptide receptor agonist affinity by reconstitution with arrestins and heterotrimeric G proteins.
The Journal of biological chemistry 2001;276(52):49204-12.
2001: Teresa A Bennett; T Alexander Key; Vsevolod V Gurevich; Richard Neubig; Eric R Prossnitz; Larry A Sklar
Real-time analysis of G protein-coupled receptor reconstitution in a solubilized system.
The Journal of biological chemistry 2001;276(25):22453-60.
2001: Bruce S Edwards; FW Kuckuck; Eric R Prossnitz; John T Ransom; Larry A Sklar
HTPS flow cytometry: a novel platform for automated high throughput drug discovery and characterization.
Journal of biomolecular screening 2001;6(2):83-90.
2001: TL Gilbert; Teresa A Bennett; Diane C Maestas; Daniel F Cimino; Eric R Prossnitz
Internalization of the human N-formyl peptide and C5a chemoattractant receptors occurs via clathrin-independent mechanisms.
Biochemistry 2001;40(12):3467-75.
2001: Bruce S Edwards; FW Kuckuck; Eric R Prossnitz; A Okun; John T Ransom; Larry A Sklar
Plug flow cytometry extends analytical capabilities in cell adhesion and receptor pharmacology.
Cytometry 2001;43(3):211-6.
2000: Teresa A Bennett; Diane C Maestas; Eric R Prossnitz
Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence.
The Journal of biological chemistry 2000;275(32):24590-4.
2000: Scott W Burchiel; Bruce S Edwards; FW Kuckuck; Fredine T Lauer; Eric R Prossnitz; John T Ransom; Larry A Sklar
Analysis of free intracellular calcium by flow cytometry: multiparameter and pharmacologic applications.
Methods (San Diego, Calif.) 2000;21(3):221-30.
2000: Larry A Sklar; J Vilven; E Lynam; D Neldon; Teresa A Bennett; Eric R Prossnitz
Solubilization and display of G protein-coupled receptors on beads for real-time fluorescence and flow cytometric analysis.
BioTechniques 2000;28(5):976-80, 982-5.
1999: D C Maestes; Ross M Potter; Eric R Prossnitz
Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor.
The Journal of biological chemistry 1999;274(42):29791-5.
1999: Eric R Prossnitz; TL Gilbert; S Chiang; J J Campbell; S Qin; W Newman; Larry A Sklar; Richard D Ye
Multiple activation steps of the N-formyl peptide receptor.
Biochemistry 1999;38(8):2240-7.
1999: TL Gilbert; Eric R Prossnitz; Larry A Sklar
The uncoupled state of the human formyl peptide receptor.
Journal of receptor and signal transduction research 1999;19(1-4):327-40.
1998: J C Vilven; M Domalewski; Eric R Prossnitz; Richard D Ye; N Muthukumaraswamy; R B Harris; R J Freer; Larry A Sklar
Strategies for positioning fluorescent probes and crosslinkers on formyl peptide ligands.
Journal of receptor and signal transduction research 1998;18(2-3):187-221.