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Christopher Proud

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Ze Zhang; Paul A Townsend; Rui Liu; Christopher G Proud
p90(RSK)s mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes.
Valentina Iadevaia; Eric Jan; Ze Zhang; Christopher G Proud
mTOR signaling regulates the processing of pre-rRNA in human cells.
Craig R Pigott; Jörn M Werner; Stephen J Finn; Halina Mikolajek; Claire E Moore; Curtis W Phippen; Christopher G Proud
Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains.

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All Publications

2013: Ze Zhang; Paul A Townsend; Rui Liu; Christopher G Proud
p90(RSK)s mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes.
Journal of molecular and cellular cardiology 2013;59():139-47.
2012: Valentina Iadevaia; Eric Jan; Ze Zhang; Christopher G Proud
mTOR signaling regulates the processing of pre-rRNA in human cells.
Nucleic acids research 2012;40(6):2527-39.
2012: Craig R Pigott; Jörn M Werner; Stephen J Finn; Halina Mikolajek; Claire E Moore; Curtis W Phippen; Christopher G Proud
Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains.
The Biochemical journal 2012;442(1):105-18.
2009: Susan Goto; Zhong Yao; Christopher G Proud
The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity.
The Biochemical journal 2009;423(2):279-90.
2009: Aruna D Balgi; Bruno D Fonseca; Elizabeth Donohue; Trevor C F Tsang; Patrick Lajoie; Christopher G Proud; Ivan R Nabi; Michel Roberge
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.
PloS one 2009;4(9):e7124.
2008: Yanni Wang; Brandon P H Huang; Dan S Luciani; Xuemin Wang; James D Johnson; Christopher G Proud
Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes.
Journal of molecular and cellular cardiology 2008;45(6):812-20.
2008: Xuemin Wang; Bruno D Fonseca; Hua Tang; Rui Liu; Androulla Elia; Michael J Clemens; Ulrich-Axel Bommer; Christopher G Proud
Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.
The Journal of biological chemistry 2008;283(45):30482-92.
2008: Min Suk Kim; Fang Wang; Prasanth Puthanveetil; Girish Kewalramani; Elham Hosseini-Beheshti; Natalie Ng; Yanni Wang; Ujendra Kumar; Sheila Innis; Christopher G Proud; Ashraf Abrahani; Brian Rodrigues
Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes.
Circulation research 2008;103(3):252-60.
2008: Vivian H Y Lee; Timothy Healy; Bruno D Fonseca; Amanda Hayashi; Christopher G Proud
Analysis of the regulatory motifs in eukaryotic initiation factor 4E-binding protein 1.
The FEBS journal 2008;275(9):2185-99.
2008: Ewan M Smith; Christopher G Proud
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.
The EMBO journal 2008;27(7):1005-16.
2008: Bruno D Fonseca; Vivian H-Y Lee; Christopher G Proud
The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.
The Biochemical journal 2008;411(1):141-9.
2008: Maria Buxadé; Nick Morrice; Danielle L Krebs; Christopher G Proud
The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha.
The Journal of biological chemistry 2008;283(1):57-65.
2008: Maria Buxade; Josep L Parra-Palau; Christopher G Proud
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).
Frontiers in bioscience : a journal and virtual library 2008;13():5359-73.
2008: Sonia Paytubi; Nick A Morrice; Jérôme Boudeau; Christopher G Proud
The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2.
The Biochemical journal 2008;409(1):223-31.
2007: Gert C Scheper; Marjo S van der Knaap; Christopher G Proud
Translation matters: protein synthesis defects in inherited disease.
Nature reviews. Genetics 2007;8(9):711-23.
2006: Gert C Scheper; Christopher G Proud; Marjo S van der Knaap
Defective translation initiation causes vanishing of cerebral white matter.
Trends in molecular medicine 2006;12(4):159-66.
2006: Barbara van Kollenburg; Adri A M Thomas; Gerre Vermeulen; Gesina A M Bertrand; Carola G M van Berkel; Jan C Pronk; Christopher G Proud; Marjo S van der Knaap; Gert C Scheper
Regulation of protein synthesis in lymphoblasts from vanishing white matter patients.
Neurobiology of disease 2006;21(3):496-504.
2005: Josep Lluis Parra; Maria Buxadé; Christopher G Proud
Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.
The Journal of biological chemistry 2005;280(45):37623-33.
2005: Andrew R Tee; John Blenis; Christopher G Proud
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.
FEBS letters 2005;579(21):4763-8.
2005: Maria Buxadé; Josep Lluis Parra; Simon Rousseau; Natalia Shpiro; Rodolfo Marquez; Nick Morrice; Jenny Bain; Enric Espel; Christopher G Proud
The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1.
Immunity 2005;23(2):177-89.
2005: Mark Rolfe; Laura E McLeod; Phillip F Pratt; Christopher G Proud
Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2).
The Biochemical journal 2005;388(Pt 3):973-84.
2005: Ewan M Smith; Stephen G Finn; Andrew R Tee; Gareth J Browne; Christopher G Proud
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.
The Journal of biological chemistry 2005;280(19):18717-27.
2005: Xuemin Wang; Anne Beugnet; Mirei Murakami; Shinya Yamanaka; Christopher G Proud
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.
Molecular and cellular biology 2005;25(7):2558-72.
2005: Christopher G Proud
eIF2 and the control of cell physiology.
Seminars in cell & developmental biology 2005;16(1):3-12.
2005: Josep L Parra-Palau; Gert C Scheper; Daniel E Harper; Christopher G Proud
The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo.
The Biochemical journal 2005;385(Pt 3):695-702.
2004: Christopher G Proud
Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy.
Cardiovascular research 2004;63(3):403-13.
2004: Christopher G Proud
The multifaceted role of mTOR in cellular stress responses.
DNA repair 2004;3(8-9):927-34.
2004: Wei Li; Xuemin Wang; Marjo S van der Knaap; Christopher G Proud
Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways.
Molecular and cellular biology 2004;24(8):3295-306.
2004: Gareth J Browne; Christopher G Proud
A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin.
Molecular and cellular biology 2004;24(7):2986-97.
2004: Gareth J Browne; Stephen G Finn; Christopher G Proud
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
The Journal of biological chemistry 2004;279(13):12220-31.
2004: Christopher G Proud
mTOR-mediated regulation of translation factors by amino acids.
Biochemical and biophysical research communications 2004;313(2):429-36.
2004: Christopher G Proud
Role of mTOR signalling in the control of translation initiation and elongation by nutrients.
Current topics in microbiology and immunology 2004;279():215-44.
2003: Josep-Lluis Parra-Palau; Gert C Scheper; Mary L Wilson; Christopher G Proud
Features in the N and C termini of the MAPK-interacting kinase Mnk1 mediate its nucleocytoplasmic shuttling.
The Journal of biological chemistry 2003;278(45):44197-204.
2003: Marjo S van der Knaap; Carola G M van Berkel; Jochen Herms; Rudy Van Coster; Martina Baethmann; Sakkubai Naidu; Eugen Boltshauser; Michèl A A P Willemsen; Barbara Plecko; Georg F Hoffmann; Christopher G Proud; Gert C Scheper; Jan C Pronk
eIF2B-related disorders: antenatal onset and involvement of multiple organs.
American journal of human genetics 2003;73(5):1199-207.
2003: Anne Beugnet; Xuemin Wang; Christopher G Proud
Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.
The Journal of biological chemistry 2003;278(42):40717-22.
2003: Xiuwen Tang; Lijun Wang; Christopher G Proud; C Peter Downes
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase.
The Biochemical journal 2003;374(Pt 1):137-43.
2003: Gert C Scheper; Josep Lluis Parra; Mary Wilson; Barbara van Kollenburg; Alfred C O Vertegaal; Ze-Guang Han; Christopher G Proud
The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.
Molecular and cellular biology 2003;23(16):5692-705.
2003: Lijun Wang; Mark Rolfe; Christopher G Proud
Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes.
The Biochemical journal 2003;373(Pt 2):603-11.
2003: Anne Beugnet; Andrew R Tee; Peter M Taylor; Christopher G Proud
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability.
The Biochemical journal 2003;372(Pt 2):555-66.
2003: Xuemin Wang; Wei Li; Josep Lluis Parra; Anne Beugnet; Christopher G Proud
The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.
Molecular and cellular biology 2003;23(5):1546-57.
2003: Michèle F Underhill; Clare Coley; John R Birch; Alison Findlay; Robert Kallmeier; Christopher G Proud; David C James
Engineering mRNA translation initiation to enhance transient gene expression in chinese hamster ovary cells.
Biotechnology progress 2003;19(1):121-9.
2002: Miranda Kleijn; Gert C Scheper; Mary L Wilson; Andrew R Tee; Christopher G Proud
Localisation and regulation of the eIF4E-binding protein 4E-BP3.
FEBS letters 2002;532(3):319-23.
2002: Laura E McLeod; Christopher G Proud
ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling.
FEBS letters 2002;531(3):448-52.
2002: Lijun Wang; Christopher G Proud
Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes.
FEBS letters 2002;531(2):285-9.
2002: Gareth J Browne; Christopher G Proud
Regulation of peptide-chain elongation in mammalian cells.
European journal of biochemistry / FEBS 2002;269(22):5360-8.
2002: Gert C Scheper; Christopher G Proud
Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?
European journal of biochemistry / FEBS 2002;269(22):5350-9.
2002: Christopher G Proud
Regulation of mammalian translation factors by nutrients.
European journal of biochemistry / FEBS 2002;269(22):5338-49.
2002: Christopher G Proud
Control of the translational machinery in mammalian cells.
European journal of biochemistry / FEBS 2002;269(22):5337.
2002: Lijun Wang; Christopher G Proud
Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes.
Circulation research 2002;91(9):821-9.
2002: Xuemin Wang; Maarten Janmaat; Anne Beugnet; Fiona E M Paulin; Christopher G Proud
Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin.
The Biochemical journal 2002;367(Pt 2):475-81.
2002: Jashmin Patel; Laura E McLeod; Robert G J Vries; Andrea Flynn; Xuemin Wang; Christopher G Proud
Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors.
European journal of biochemistry / FEBS 2002;269(12):3076-85.
2002: Miranda Kleijn; Christopher G Proud
The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes.
BMC biochemistry 2002;3():11.
2002: Terence P Herbert; Andrew R Tee; Christopher G Proud
The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites.
The Journal of biological chemistry 2002;277(13):11591-6.
2002: Graham R Christie; Eric Hajduch; Harinder S Hundal; Christopher G Proud; Peter M Taylor
Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner.
The Journal of biological chemistry 2002;277(12):9952-7.
2002: Andrew R Tee; Christopher G Proud
Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif.
Molecular and cellular biology 2002;22(6):1674-83.
2002: Gert C Scheper; Barbara van Kollenburg; Jianzhong HU; Yunjing Luo; Dixie J Goss; Christopher G Proud
Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.
The Journal of biological chemistry 2002;277(5):3303-9.
2002: Linda E Campbell; Christopher G Proud
Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases.
FEBS letters 2002;510(1-2):31-6.
2001: Wei Li; Natalie Ross-Smith; Christopher G Proud; Graham J Belsham
Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site.
FEBS letters 2001;507(1):1-5.
2001: J Patel; Xuemin Wang; Christopher G Proud
Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1.
The Biochemical journal 2001;358(Pt 2):497-503.
2001: Lijun Wang; I Gout; Christopher G Proud
Cross-talk between the ERK and p70 S6 kinase (S6K) signaling pathways. MEK-dependent activation of S6K2 in cardiomyocytes.
The Journal of biological chemistry 2001;276(35):32670-7.
2001: Xuemin Wang; Wei Li; M Williams; N Terada; Dario R Alessi; Christopher G Proud
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
The EMBO journal 2001;20(16):4370-9.
2001: Xuemin Wang; Fiona E M Paulin; Linda E Campbell; E Gomez; K O'Brien; Nick Morrice; Christopher G Proud
Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo.
The EMBO journal 2001;20(16):4349-59.
2001: Wei Li; Graham J Belsham; Christopher G Proud
Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.
The Journal of biological chemistry 2001;276(31):29111-5.
2001: Andrew R Tee; Christopher G Proud
Staurosporine inhibits phosphorylation of translational regulators linked to mTOR.
Cell death and differentiation 2001;8(8):841-9.
2001: Christopher G Proud; Xuemin Wang; J V Patel; Linda E Campbell; Miranda Kleijn; Wei Li; Gareth J Browne
Interplay between insulin and nutrients in the regulation of translation factors.
Biochemical Society transactions 2001;29(Pt 4):541-7.
2001: D D Williams; NT Price; AJ Loughlin; Christopher G Proud
Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein.
The Journal of biological chemistry 2001;276(27):24697-703.
2001: Yvonne L Woods; Philip Cohen; Walter Becker; Ross Jakes; Michel Goedert; Xuemin Wang; Christopher G Proud
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.
The Biochemical journal 2001;355(Pt 3):609-15.
2001: D D Williams; G D Pavitt; Christopher G Proud
Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster.
The Journal of biological chemistry 2001;276(6):3733-42.
2001: Laura E McLeod; Lijun Wang; Christopher G Proud
beta-Adrenergic agonists increase phosphorylation of elongation factor 2 in cardiomyocytes without eliciting calcium-independent eEF2 kinase activity.
FEBS letters 2001;489(2-3):225-8.
2001: Gert C Scheper; Nick A Morrice; Miranda Kleijn; Christopher G Proud
The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.
Molecular and cellular biology 2001;21(3):743-54.
2001: Fiona E M Paulin; Linda E Campbell; K O'Brien; J Loughlin; Christopher G Proud
Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase-activator protein.
Current biology : CB 2001;11(1):55-9.
2001: Christopher G Proud
Regulation of eukaryotic initiation factor eIF2B.
Progress in molecular and subcellular biology 2001;26():95-114.
2000: J K Tyzack; Xuemin Wang; Graham J Belsham; Christopher G Proud
ABC50 interacts with eukaryotic initiation factor 2 and associates with the ribosome in an ATP-dependent manner.
The Journal of biological chemistry 2000;275(44):34131-9.
2000: Miranda Kleijn; Christopher G Proud
The activation of eukaryotic initiation factor (eIF)2B by growth factors in PC12 cells requires MEK/ERK signalling.
FEBS letters 2000;476(3):262-5.
2000: Terence P Herbert; Robin Fåhraeus; Alan R Prescott; David P Lane; Christopher G Proud
Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E.
Current biology : CB 2000;10(13):793-6.
2000: Andrew R Tee; Christopher G Proud
DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling.
Oncogene 2000;19(26):3021-31.
2000: Miranda Kleijn; Christopher G Proud
Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells.
The Biochemical journal 2000;347(Pt 2):399-406.
2000: Terence P Herbert; G R Kilhams; Ian H Batty; Christopher G Proud
Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells.
The Journal of biological chemistry 2000;275(15):11249-56.
2000: Lijun Wang; Xuemin Wang; Christopher G Proud
Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps.
American journal of physiology. Heart and circulatory physiology 2000;278(4):H1056-68.
1999: Linda E Campbell; Xuemin Wang; Christopher G Proud
Nutrients differentially regulate multiple translation factors and their control by insulin.
The Biochemical journal 1999;344 Pt 2():433-41.
1999: D D Williams; O Marin; L A Pinna; Christopher G Proud
Phosphorylated seryl and threonyl, but not tyrosyl, residues are efficient specificity determinants for GSK-3beta and Shaggy.
FEBS letters 1999;448(1):86-90.
1998: Xuemin Wang; Linda E Campbell; C M Miller; Christopher G Proud
Amino acid availability regulates p70 S6 kinase and multiple translation factors.
The Biochemical journal 1998;334 ( Pt 1)():261-7.
1998: Gavin I Welsh; D A Hall; A Warnes; Philip G Strange; Christopher G Proud
Activation of microtubule-associated protein kinase (Erk) and p70 S6 kinase by D2 dopamine receptors.
Journal of neurochemistry 1998;70(5):2139-46.
1998: Xuemin Wang; Andrea Flynn; Andrew J Waskiewicz; B L Webb; Robert G J Vries; I A Baines; Jonathan A Cooper; Christopher G Proud
The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways.
The Journal of biological chemistry 1998;273(16):9373-7.
1998: Miranda Kleijn; G I Welsh; Gert C Scheper; Harry O Voorma; Christopher G Proud; Adri A M Thomas
Nerve and epidermal growth factor induce protein synthesis and eIF2B activation in PC12 cells.
The Journal of biological chemistry 1998;273(10):5536-41.
1998: Gavin I Welsh; C M Miller; AJ Loughlin; NT Price; Christopher G Proud
Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin.
FEBS letters 1998;421(2):125-30.
1997: Robert G J Vries; Andrea Flynn; J C Patel; Xuemin Wang; R M Denton; Christopher G Proud
Heat shock increases the association of binding protein-1 with initiation factor 4E.
The Journal of biological chemistry 1997;272(52):32779-84.
1997: Christopher G Proud; R M Denton
Molecular mechanisms for the control of translation by insulin.
The Biochemical journal 1997;328 ( Pt 2)():329-41.
1997: B L Webb; Christopher G Proud
Eukaryotic initiation factor 2B (eIF2B).
The international journal of biochemistry & cell biology 1997;29(10):1127-31.
1997: Xuemin Wang; Christopher G Proud
p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinase.
Biochemical and biophysical research communications 1997;238(1):207-12.
1997: Gavin I Welsh; C M Stokes; Xuemin Wang; Hiroshi Sakaue; Wataru Ogawa; M Kasuga; Christopher G Proud
Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3-kinase.
FEBS letters 1997;410(2-3):418-22.
1997: Andrea Flynn; Robert G J Vries; Christopher G Proud
Signalling pathways which regulate eIF4E.
Biochemical Society transactions 1997;25(2):192S.
1997: Gavin I Welsh; AJ Loughlin; Emily J Foulstone; NT Price; Christopher G Proud
Regulation of initiation factor eIF-2B by GSK-3 regulated phosphorylation.
Biochemical Society transactions 1997;25(2):191S.
1997: Andrew J Waskiewicz; Andrea Flynn; Christopher G Proud; Jonathan A Cooper
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.
The EMBO journal 1997;16(8):1909-20.
1997: S Kelly Moule; Gavin I Welsh; N J Edgell; Emily J Foulstone; Christopher G Proud; Richard M Denton
Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms.
The Journal of biological chemistry 1997;272(12):7713-9.
1997: Gavin I Welsh; J C Patel; Christopher G Proud
Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.
Analytical biochemistry 1997;244(1):16-21.
1996: Nigel T Price; H Mellor; B L Craddock; K M Flowers; Scot R Kimball; T Wilmer; Leonard S Jefferson; Christopher G Proud
eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast.
The Biochemical journal 1996;318 ( Pt 2)():637-43.
1996: Nigel T Price; Scot R Kimball; Leonard S Jefferson; Christopher G Proud
Cloning of cDNA for the gamma-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2.
The Biochemical journal 1996;318 ( Pt 2)():631-6.
1996: N T Redpath; Nigel T Price; Christopher G Proud
Cloning and expression of cDNA encoding protein synthesis elongation factor-2 kinase.
The Journal of biological chemistry 1996;271(29):17547-54.
1996: Gavin I Welsh; C Wilson; Christopher G Proud
GSK3: a SHAGGY frog story.
Trends in cell biology 1996;6(7):274-9.
1996: TA Diggle; S Kelly Moule; M B Avison; A Flynn; Emily J Foulstone; Christopher G Proud; Richard M Denton
Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat epididymal fat-cells.
The Biochemical journal 1996;316 ( Pt 2)():447-53.
1996: Gavin I Welsh; S Miyamoto; Nigel T Price; B Safer; Christopher G Proud
T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3.
The Journal of biological chemistry 1996;271(19):11410-3.
1996: Christopher G Proud
p70 S6 kinase: an enigma with variations.
Trends in biochemical sciences 1996;21(5):181-5.
1996: N T Redpath; Emily J Foulstone; Christopher G Proud
Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway.
The EMBO journal 1996;15(9):2291-7.
1996: B L Craddock; Christopher G Proud
The alpha-subunit of the mammalian guanine nucleotide-exchange factor eIF-2B is essential for catalytic activity in vitro.
Biochemical and biophysical research communications 1996;220(3):843-7.
1996: Andrea Flynn; Christopher G Proud
Insulin and phorbol ester stimulate initiation factor eIF-4E phosphorylation by distinct pathways in Chinese hamster ovary cells overexpressing the insulin receptor.
European journal of biochemistry / FEBS 1996;236(1):40-7.
1996: MG Gilligan; Gavin I Welsh; A Flynn; Iwona J Bujalska; TA Diggle; Richard M Denton; Christopher G Proud; Kevin Docherty
Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans.
The Journal of biological chemistry 1996;271(4):2121-5.
1996: Andrea Flynn; Christopher G Proud
The role of eIF4 in cell proliferation.
Cancer surveys 1996;27():293-310.
1995: S Kelly Moule; N J Edgell; Gavin I Welsh; TA Diggle; Emily J Foulstone; Kate J Heesom; Christopher G Proud; Richard M Denton
Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells.
The Biochemical journal 1995;311 ( Pt 2)():595-601.
1995: A Flynn; Christopher G Proud
Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells.
The Journal of biological chemistry 1995;270(37):21684-8.
1995: B L Craddock; Nigel T Price; Christopher G Proud
Cloning and expression of cDNAs for the beta subunit of eukaryotic initiation factor-2B, the guanine nucleotide exchange factor for eukaryotic initiation factor-2.
The Biochemical journal 1995;309 ( Pt 3)():1009-14.
1995: Christopher G Proud
PKR: a new name and new roles.
Trends in biochemical sciences 1995;20(6):241-6.
1995: S Kelly Moule; N J Edgell; Gavin I Welsh; TA Diggle; Christopher G Proud; Richard M Denton
Studies with wortmannin indicate that insulin stimulation of lipogenesis involves multiple signalling pathways.
Biochemical Society transactions 1995;23(2):206S.
1994: A Flynn; I N Shatsky; Christopher G Proud; A Kaminski
The RNA-binding properties of protein synthesis initiation factor eIF-2.
Biochimica et biophysica acta 1994;1219(2):293-301.
1994: Gavin I Welsh; Emily J Foulstone; S W Young; Jeremy M Tavaré; Christopher G Proud
Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase.
The Biochemical journal 1994;303 ( Pt 1)():15-20.
1994: Gavin I Welsh; Nigel T Price; B A Bladergroen; Graham B Bloomberg; Christopher G Proud
Identification of novel phosphorylation sites in the beta-subunit of translation initiation factor eIF-2.
Biochemical and biophysical research communications 1994;201(3):1279-88.
1994: Christopher G Proud
Peptide-chain elongation in eukaryotes.
Molecular biology reports 1994;19(3):161-70.
1994: S Oldfield; B L Jones; D Tanton; Christopher G Proud
Use of monoclonal antibodies to study the structure and function of eukaryotic protein synthesis initiation factor eIF-2B.
European journal of biochemistry / FEBS 1994;221(1):399-410.
1994: Nigel T Price; G Francia; Len Hall; Christopher G Proud
Guanine nucleotide exchange factor for eukaryotic initiation factor-2. Cloning of cDNA for the delta-subunit of rabbit translation initiation factor-2B.
Biochimica et biophysica acta 1994;1217(2):207-10.
1994: N T Redpath; Christopher G Proud
Molecular mechanisms in the control of translation by hormones and growth factors.
Biochimica et biophysica acta 1994;1220(2):147-62.
1994: N Price; Christopher G Proud
The guanine nucleotide-exchange factor, eIF-2B.
Biochimie 1994;76(8):748-60.
1993: Nigel T Price; Len Hall; Christopher G Proud
Cloning of cDNA for the beta-subunit of rabbit translation initiation factor-2 using PCR.
Biochimica et biophysica acta 1993;1216(1):170-2.
1993: T V Sharp; Martin Schwemmle; I Jeffrey; K Laing; H Mellor; Christopher G Proud; K Hilse; Michael J Clemens
Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA.
Nucleic acids research 1993;21(19):4483-90.
1993: Gavin I Welsh; Christopher G Proud
Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.
The Biochemical journal 1993;294 ( Pt 3)():625-9.
1993: S Oldfield; Christopher G Proud
Phosphorylation of elongation factor-2 from the lepidopteran insect, Spodoptera frugiperda.
FEBS letters 1993;327(1):71-4.
1993: A Flynn; S Oldfield; Christopher G Proud
The role of the beta-subunit of initiation factor eIF-2 in initiation complex formation.
Biochimica et biophysica acta 1993;1174(1):117-21.
1993: N T Redpath; Christopher G Proud
Cyclic AMP-dependent protein kinase phosphorylates rabbit reticulocyte elongation factor-2 kinase and induces calcium-independent activity.
The Biochemical journal 1993;293 ( Pt 1)():31-4.
1993: N T Redpath; Nigel T Price; K V Severinov; Christopher G Proud
Regulation of elongation factor-2 by multisite phosphorylation.
European journal of biochemistry / FEBS 1993;213(2):689-99.
1993: N T Redpath; Christopher G Proud
Purification and phosphorylation of elongation factor-2 kinase from rabbit reticulocytes.
European journal of biochemistry / FEBS 1993;212(2):511-20.
1993: Gavin I Welsh; Christopher G Proud
Evidence for a role for protein kinase C in the stimulation of protein synthesis by insulin in swiss 3T3 fibroblasts.
FEBS letters 1993;316(3):241-6.
1993: H Mellor; Nigel T Price; S Oldfield; T F Sarre; Christopher G Proud
Purification and characterisation of an initiation-factor-2 kinase from uninduced mouse erythroleukaemia cells.
European journal of biochemistry / FEBS 1993;211(3):529-38.
1992: S Oldfield; Christopher G Proud
Purification, phosphorylation and control of the guanine-nucleotide-exchange factor from rabbit reticulocyte lysates.
European journal of biochemistry / FEBS 1992;208(1):73-81.
1992: Gavin I Welsh; Christopher G Proud
Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors.
The Biochemical journal 1992;284 ( Pt 1)():19-23.
1992: Christopher G Proud
Protein phosphorylation in translational control.
Current topics in cellular regulation 1992;32():243-369.
1991: S R Green; A Spalding; T Ashford; Christopher G Proud; Mick F Tuite
Synthesis of human initiation factor-2 alpha in Saccharomyces cerevisiae.
Gene 1991;108(2):253-8.
1991: U A Bommer; R Kraft; T V Kurzchalia; Nigel T Price; Christopher G Proud
Amino acid sequence analysis of the beta- and gamma-subunits of eukaryotic initiation factor eIF-2. Identification of regions interacting with GTP.
Biochimica et biophysica acta 1991;1079(3):308-15.
1991: H Mellor; Christopher G Proud
A synthetic peptide substrate for initiation factor-2 kinases.
Biochemical and biophysical research communications 1991;178(2):430-7.
1991: N T Redpath; Christopher G Proud
Differing effects of the protein phosphatase inhibitors okadaic acid and microcystin on translation in reticulocyte lysates.
Biochimica et biophysica acta 1991;1093(1):36-41.
1991: Nigel T Price; Gavin I Welsh; Christopher G Proud
Phosphorylation of only serine-51 in protein synthesis initiation factor-2 is associated with inhibition of peptide-chain initiation in reticulocyte lysates.
Biochemical and biophysical research communications 1991;176(3):993-9.
1991: Nigel T Price; N T Redpath; K V Severinov; D G Campbell; J M Russell; Christopher G Proud
Identification of the phosphorylation sites in elongation factor-2 from rabbit reticulocytes.
FEBS letters 1991;282(2):253-8.
1991: Christopher G Proud; D R Colthurst; S Ferrari; L A Pinna
The substrate specificity of protein kinases which phosphorylate the alpha subunit of eukaryotic initiation factor 2.
European journal of biochemistry / FEBS 1991;195(3):771-9.
1990: N T Redpath; Christopher G Proud
Activity of protein phosphatases against initiation factor-2 and elongation factor-2.
The Biochemical journal 1990;272(1):175-80.
1990: Nigel T Price; Christopher G Proud
Phosphorylation of protein synthesis initiation factor-2. Identification of the site in the alpha-subunit phosphorylated in reticulocyte lysates.
Biochimica et biophysica acta 1990;1054(1):83-8.
1989: N T Redpath; Christopher G Proud
The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2.
The Biochemical journal 1989;262(1):69-75.
1989: Nigel T Price; S F Nakielny; S J Clark; Christopher G Proud
The two forms of the beta-subunit of initiation factor-2 from reticulocyte lysates arise from proteolytic degradation.
Biochimica et biophysica acta 1989;1008(2):177-82.
1989: S J Clark; A J Ashford; Nigel T Price; Christopher G Proud
Casein kinase-2 phosphorylates serine-2 in the beta-subunit of initiation factor-2.
Biochimica et biophysica acta 1989;1010(3):377-80.
1988: S Cox; N T Redpath; Christopher G Proud
Regulation of polypeptide-chain initiation in rat skeletal muscle. Starvation does not alter the activity or phosphorylation state of initiation factor eIF-2.
FEBS letters 1988;239(2):333-8.
1988: S Cox; Christopher G Proud
The effect of ethanol on polypeptide chain initiation in reticulocyte lysates. Inhibition of recycling of initiation factor eIF-2.
Biochemical pharmacology 1988;37(10):2045-9.
1988: S J Clark; D R Colthurst; Christopher G Proud
Structure and phosphorylation of eukaryotic initiation factor 2. Casein kinase 2 and protein kinase C phosphorylate distinct but adjacent sites in the beta-subunit.
Biochimica et biophysica acta 1988;968(2):211-9.
1987: D R Colthurst; D G Campbell; Christopher G Proud
Structure and regulation of eukaryotic initiation factor eIF-2. Sequence of the site in the alpha subunit phosphorylated by the haem-controlled repressor and by the double-stranded RNA-activated inhibitor.
European journal of biochemistry / FEBS 1987;166(2):357-63.
1986: D R Colthurst; Christopher G Proud
Eukaryotic initiation factor 2 from rat liver: no apparent function for the beta-subunit in the formation of initiation complexes.
Biochimica et biophysica acta 1986;868(1):77-86.