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Miguel Prudêncio

Research Profile

Disorders

Malaria

Anatomy

Chemicals & Drugs

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Electron Spin Resonance Spectroscopy

Physiology

Amino Acid Substitution

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Publications

TOP 3
Jing-Wen Lin; Gunnar R Mair; Kai Matuschewski; Patrícia Meireles; Carolin Nahar; Miguel Prudêncio; Jai Ramesar; Mohammed Sajid; Andrew P Waters; Takeshi Annoura; Cristina M C Avramut; Séverine Chevalley-Maurel; Sabine Engelmann; Chris J Janse; Abraham Koster; Shahid M Khan
Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.
Bianca Pérez; Miguel Prudêncio; Philip J Rosenthal; Cátia Teixeira; Inês S Albuquerque; Ana S Gomes; Jiri Gut; Paula Gomes
In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites.
Bianca C Pérez; Miguel Prudêncio; Philip J Rosenthal; Cátia Teixeira; Inês S Albuquerque; José R B Gomes; Jiri Gut; Paula Gomes
N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads.

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All Publications

2013: Jing-Wen Lin; Gunnar R Mair; Kai Matuschewski; Patrícia Meireles; Carolin Nahar; Miguel Prudêncio; Jai Ramesar; Mohammed Sajid; Andrew P Waters; Takeshi Annoura; Cristina M C Avramut; Séverine Chevalley-Maurel; Sabine Engelmann; Chris J Janse; Abraham Koster; Shahid M Khan
Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.
Molecular microbiology 2013;88(2):318-38.
2013: Bianca Pérez; Miguel Prudêncio; Philip J Rosenthal; Cátia Teixeira; Inês S Albuquerque; Ana S Gomes; Jiri Gut; Paula Gomes
In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites.
Bioorganic & medicinal chemistry letters 2013;23(3):610-3.
2013: Bianca C Pérez; Miguel Prudêncio; Philip J Rosenthal; Cátia Teixeira; Inês S Albuquerque; José R B Gomes; Jiri Gut; Paula Gomes
N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads.
Journal of medicinal chemistry 2013;56(2):556-67.
2013: Miguel Prudêncio; Maria M Mota
Targeting host factors to circumvent anti-malarial drug resistance.
Current pharmaceutical design 2013;19(2):290-9.
2012: Emily R Derbyshire; Maria M Mota; Miguel Prudêncio; Jon Clardy
Liver-stage malaria parasites vulnerable to diverse chemical scaffolds.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(22):8511-6.
2012: Filipa P da Cruz; Francisco-Javier Gamo; Michael Hannus; Maria J Lafuente-Monasterio; Matthias Marti; Cécilie Martin; Rui Moreira; Maria M Mota; Tiago Rodrigues; Birte soennichsen; Kathrin Buchholz; Miguel Prudêncio
Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug.
The Journal of infectious diseases 2012;205(8):1278-86.
2012: Joana Matos; Rui Moreira; Fátima Nogueira; Miguel Prudêncio; Philip J Rosenthal; Élia Cabrita; Filipa P da Cruz; Virgílio E do Rosário; Jiri Gut; Paula Gomes
Novel potent metallocenes against liver stage malaria.
Antimicrobial agents and chemotherapy 2012;56(3):1564-70.
2012: Tiago Rodrigues; Rui Moreira; Maria M Mota; Miguel Prudêncio; Francisca Lopes
Targeting the liver stage of malaria parasites: a yet unmet goal.
Journal of medicinal chemistry 2012;55(3):995-1012.
2011: Cátia Ramalhete; Virgílio E do Rosário; Filipa P da Cruz; Dinora Lopes; Silva Mulhovo; Miguel Prudêncio; Maria-José Umbelino Ferreira
Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections.
Bioorganic & medicinal chemistry 2011;19(24):7474-81.
2011: Miguel Prudêncio; Maria M Mota; António M Mendes
A toolbox to study liver stage malaria.
Trends in parasitology 2011;27(12):565-74.
2011: Rita Capela; Jiri Gut; Francisca Lopes; Rui Moreira; Maria M Mota; Ghislain G Cabal; Philip J Rosenthal; Miguel Prudêncio
Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy.
Antimicrobial agents and chemotherapy 2011;55(10):4698-706.
2011: Ksenija Slavic; Michael Delves; Miguel Prudêncio; Arthur M Talman; Ursula Straschil; Elvira T Derbyshire; Zhengyao Xu; Robert E Sinden; Maria M Mota; Christophe Morin; Rita Tewari; Sanjeev Krishna; Henry M Staines
Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle.
Antimicrobial agents and chemotherapy 2011;55(6):2824-30.
2011: Carina S S Gomes-Santos; Joanna Braks; Miguel Prudêncio; Céline Carret; Ana Rita Gomes; Arnab Pain; Theresa Feltwell; Shahid Khan; Andrew Waters; Chris J Janse; Gunnar R Mair; Maria M Mota
Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio.
PLoS pathogens 2011;7(5):e1002046.
2011: João Lavrado; Rui Moreira; Maria M Mota; Elena Bichenkova; Ghislain G Cabal; Cecília Díaz; Daniel J V A dos Santos; Kenneth T Douglas; Rita C Guedes; Jiri Gut; Miguel Prudêncio; Philip J Rosenthal; Alexandra Paulo
Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies.
Journal of medicinal chemistry 2011;54(3):734-50.
2009: Nuno Vale; Miguel Prudêncio; Catarina de Almeida Marques; Margaret S Collins; Jiri Gut; Fátima Nogueira; Joana Matos; Philip J Rosenthal; Melanie T Cushion; Virgílio E do Rosário; Maria M Mota; Rui Moreira; Paula Gomes
Imidazoquines as antimalarial and antipneumocystis agents.
Journal of medicinal chemistry 2009;52(23):7800-7.
2009: Miguel Prudêncio; Elvira T Derbyshire; Catarina de Almeida Marques; Sanjeev Krishna; Maria M Mota; Henry M Staines
Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells.
Cellular microbiology 2009;11(10):1492-501.
2009: Miguel Prudêncio; Maik J Lehmann
Illuminating the host - how RNAi screens shed light on host-pathogen interactions.
Biotechnology journal 2009;4(6):826-37.
2009: Ivo Ploemen; Miguel Prudêncio; Bruno G Douradinha; Jai Ramesar; Jannik Fonager; Geert-Jan van Gemert; Adrian J F Luty; Cornelus C Hermsen; Robert W Sauerwein; Fernanda G Baptista; Maria M Mota; Andrew P Waters; Ivo Que; Clemens W G M Lowik; Shahid M Khan; Chris J Janse; Blandine M D Franke-Fayard
Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging.
PloS one 2009;4(11):e7881.
2009: Sónia S Albuquerque; Céline Carret; Ana Rita Grosso; Alice S Tarun; Xinxia Peng; Stefan Kappe; Miguel Prudêncio; Maria M Mota
Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events.
BMC genomics 2009;10():270.
2009: Iana Parvanova; Sabrina Epiphanio; Abdul Fauq; todd golde; Miguel Prudêncio; Maria M Mota
A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity.
PloS one 2009;4(4):e5078.
2008: Michelina G Finiguerra; Miguel Prudêncio; Marcellus Ubbink; Martina Huber
Accurate long-range distance measurements in a doubly spin-labeled protein by a four-pulse, double electron-electron resonance method.
Magnetic resonance in chemistry : MRC 2008;46(12):1096-101.
2008: Miguel Prudêncio; Cristina D Rodrigues; Michael Hannus; Cécilie Martin; Eliana Real; Lígia Antunes Gonçalves; Céline Carret; Robert Dorkin; Ingo Röhl; Kerstin Jahn-Hoffmann; Adrian J F Luty; Robert W Sauerwein; Christophe J Echeverri; Maria M Mota
Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection.
PLoS pathogens 2008;4(11):e1000201.
2008: Cristina D Rodrigues; Michael Hannus; Miguel Prudêncio; Cécilie Martin; Lígia Antunes Gonçalves; Sílvia Portugal; Sabrina Epiphanio; Akin Akinc; Philipp Hadwiger; Kerstin Jahn-Hofmann; Ingo Röhl; Geert-Jan van Gemert; Jean-François Franetich; Adrian J F Luty; Robert W Sauerwein; Dominique Mazier; Victor Koteliansky; Hans-Peter Vornlocher; Christophe J Echeverri; Maria M Mota
Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection.
Cell host & microbe 2008;4(3):271-82.
2008: Olivier Silvie; Maria M Mota; Kai Matuschewski; Miguel Prudêncio
Interactions of the malaria parasite and its mammalian host.
Current opinion in microbiology 2008;11(4):352-9.
2008: Monica Vlasie; Rubén Fernández-Busnadiego; Miguel Prudêncio; Marcellus Ubbink
Conformation of pseudoazurin in the 152 kDa electron transfer complex with nitrite reductase determined by paramagnetic NMR.
Journal of molecular biology 2008;375(5):1405-15.
2008: Margarida Cunha-Rodrigues; Sílvia Portugal; Miguel Prudêncio; Lígia Antunes Gonçalves; Cristina Casalou; Dominik Buger; Robert W Sauerwein; Werner Haas; Maria M Mota
Genistein-supplemented diet decreases malaria liver infection in mice and constitutes a potential prophylactic strategy.
PloS one 2008;3(7):e2732.
2008: Miguel Prudêncio; Cristina D Rodrigues; Ricardo Ataíde; Maria M Mota
Dissecting in vitro host cell infection by Plasmodium sporozoites using flow cytometry.
Cellular microbiology 2008;10(1):218-24.
2007: Miguel Prudêncio; Maria M Mota
To migrate or to invade: those are the options.
Cell host & microbe 2007;2(5):286-8.
2007: Miguel Prudêncio; Cristina D Rodrigues; Maria M Mota
The relevance of host genes in malaria.
SEB experimental biology series 2007;58():47-91.
2007: Monica Vlasie; Clara Comuzzi; Adrianus M C H van den Nieuwendijk; Miguel Prudêncio; Mark Overhand; Marcellus Ubbink
Long-range-distance NMR effects in a protein labeled with a lanthanide-DOTA chelate.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(6):1715-23.
2006: Miguel Prudêncio; Ana Rodriguez; Maria M Mota
The silent path to thousands of merozoites: the Plasmodium liver stage.
Nature reviews. Microbiology 2006;4(11):849-56.
2006: Margarida Cunha-Rodrigues; Miguel Prudêncio; Maria M Mota; Werner Haas
Antimalarial drugs - host targets (re)visited.
Biotechnology journal 2006;1(3):321-32.
2005: Jonathan A R Worrall; Rutger Diederix; Miguel Prudêncio; Christian E Lowe; Simone Ciofi-Baffoni; Marcellus Ubbink; Gerard W Canters
The effects of ligand exchange and mobility on the peroxidase activity of a bacterial cytochrome c upon unfolding.
Chembiochem : a European journal of chemical biology 2005;6(4):747-58.
2005: Roger L Harris; Miguel Prudêncio; S Samar Hasnain; Robert R Eady; R Gary Sawers
Heterologous metalloprotein biosynthesis in Escherichia coli: conditions for the overproduction of functional copper-containing nitrite reductase and azurin from Alcaligenes xylosoxidans.
Journal of synchrotron radiation 2005;12(Pt 1):13-8.
2004: Miguel Prudêncio; Marcellus Ubbink
Transient complexes of redox proteins: structural and dynamic details from NMR studies.
Journal of molecular recognition : JMR 2004;17(6):524-39.
2004: Miguel Prudêncio; Jan Rohovec; Joop A Peters; Elitza I Tocheva; Martin J Boulanger; Michael E P Murphy; Hermen-Jan Hupkes; Walter Kosters; Antonietta Impagliazzo; Marcellus Ubbink
A caged lanthanide complex as a paramagnetic shift agent for protein NMR.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(13):3252-60.
2004: Ole Farver; Robert R Eady; Gary Sawers; Miguel Prudêncio; Israel Pecht
Met144Ala mutation of the copper-containing nitrite reductase from Alcaligenes xylosoxidans reverses the intramolecular electron transfer.
FEBS letters 2004;561(1-3):173-6.
2002: Miguel Prudêncio; Gary Sawers; Shirley A Fairhurst; Faridoon K Yousafzai; Robert R Eady
Alcaligenes xylosoxidans dissimilatory nitrite reductase: alanine substitution of the surface-exposed histidine 139l ligand of the type 1 copper center prevents electron transfer to the catalytic center.
Biochemistry 2002;41(10):3430-8.
2002: Mark J Ellis; Miguel Prudêncio; Fraser E Dodd; Richard W Strange; Gary Sawers; Robert R Eady; S Samar Hasnain
Biochemical and crystallographic studies of the Met144Ala, Asp92Asn and His254Phe mutants of the nitrite reductase from Alcaligenes xylosoxidans provide insight into the enzyme mechanism.
Journal of molecular biology 2002;316(1):51-64.
2001: Mark J Ellis; Fraser E Dodd; Richard W Strange; Miguel Prudêncio; Gary Sawers; Robert R Eady; S Samar Hasnain
X-ray structure of a blue copper nitrite reductase at high pH and in copper-free form at 1.9 A resolution.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 8):1110-8.
2001: Miguel Prudêncio; Robert R Eady; Gary Sawers
Catalytic and spectroscopic analysis of blue copper-containing nitrite reductase mutants altered in the environment of the type 2 copper centre: implications for substrate interaction.
The Biochemical journal 2001;353(Pt 2):259-66.
1999: Miguel Prudêncio; Robert R Eady; Gary Sawers
The blue copper-containing nitrite reductase from Alcaligenes xylosoxidans: cloning of the nirA gene and characterization of the recombinant enzyme.
Journal of bacteriology 1999;181(8):2323-9.