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Michelle Prudhomme

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Chemicals & Drugs

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Rufine Akué-Gédu; Emilie Rossignol; Stéphane Azzaro; Stefan Knapp; Panagis Filippakopoulos; Alex N Bullock; Jenny Bain; Philip Cohen; Michelle Prudhomme; Fabrice Anizon; Pascale Moreau
Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors.
Fabrice Anizon; Roy M Golsteyn; Stéphane Léonce; Bruno Pfeiffer; Michelle Prudhomme
A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor.
Christelle Marminon; Fabrice Anizon; Pascale Moreau; Bruno Pfeiffer; Alain Pierré; Roy M Golsteyn; Paul Peixoto; Marie-Paule Hildebrand; Marie-Hélène David-Cordonnier; Olivier Lozach; Laurent Meijer; Michelle Prudhomme
Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.

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All Publications

2009: Rufine Akué-Gédu; Emilie Rossignol; Stéphane Azzaro; Stefan Knapp; Panagis Filippakopoulos; Alex N Bullock; Jenny Bain; Philip Cohen; Michelle Prudhomme; Fabrice Anizon; Pascale Moreau
Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors.
Journal of medicinal chemistry 2009;52(20):6369-81.
2009: Fabrice Anizon; Roy M Golsteyn; Stéphane Léonce; Bruno Pfeiffer; Michelle Prudhomme
A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor.
European journal of medicinal chemistry 2009;44(5):2234-8.
2008: Christelle Marminon; Fabrice Anizon; Pascale Moreau; Bruno Pfeiffer; Alain Pierré; Roy M Golsteyn; Paul Peixoto; Marie-Paule Hildebrand; Marie-Hélène David-Cordonnier; Olivier Lozach; Laurent Meijer; Michelle Prudhomme
Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.
Molecular pharmacology 2008;74(6):1620-9.
2008: Fadoua Bouchikhi; Emilie Rossignol; Martine Sancelme; Bettina Aboab; Fabrice Anizon; Doriano Fabbro; Michelle Prudhomme; Pascale Moreau
Synthesis and biological evaluation of diversely substituted indolin-2-ones.
European journal of medicinal chemistry 2008;43(11):2316-22.
2008: Emilie Rossignol; Eric Debiton; Doriano Fabbro; Pascale Moreau; Michelle Prudhomme; Fabrice Anizon
In-vitro antiproliferative activities and kinase inhibitory potencies of meridianin derivatives.
Anti-cancer drugs 2008;19(8):789-92.
2008: Hélène Hénon; Elisabeth Conchon; Bernadette Hugon; Samir Messaoudi; Roy M Golsteyn; Michelle Prudhomme
Pyrrolocarbazoles as checkpoint 1 kinase inhibitors.
Anti-cancer agents in medicinal chemistry 2008;8(6):577-97.
2008: Michelle Prudhomme
Editorial. Reviews by editorial board.
Anti-cancer agents in medicinal chemistry 2008;8(6):576.
2008: Elisabeth Conchon; Fabrice Anizon; Bettina Aboab; Roy M Golsteyn; Stéphane Léonce; Bruno Pfeiffer; Michelle Prudhomme
Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.
Bioorganic & medicinal chemistry 2008;16(8):4419-30.
2008: Elisabeth Conchon; Fabrice Anizon; Bettina Aboab; Roy M Golsteyn; Stéphane Léonce; Bruno Pfeiffer; Michelle Prudhomme
Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone.
European journal of medicinal chemistry 2008;43(2):282-92.
2007: Mathieu Sassatelli; Fadoua Bouchikhi; Bettina Aboab; Fabrice Anizon; Doriano Fabbro; Michelle Prudhomme; Pascale Moreau
In-vitro antiproliferative activities and kinase inhibitory potencies of glycosyl-isoindigo derivatives.
Anti-cancer drugs 2007;18(9):1069-74.
2007: Elisabeth Conchon; Fabrice Anizon; Bettina Aboab; Michelle Prudhomme
Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.
Journal of medicinal chemistry 2007;50(19):4669-80.
2007: Bernadette Hugon; Fabrice Anizon; Christian Bailly; Roy M Golsteyn; Alain Pierré; Stéphane Léonce; John Hickman; Bruno Pfeiffer; Michelle Prudhomme
Synthesis and biological activities of isogranulatimide analogues.
Bioorganic & medicinal chemistry 2007;15(17):5965-80.
2007: Hélène Hénon; Samir Messaoudi; Fabrice Anizon; Bettina Aboab; Nathalie Kucharczyk; Stéphane Léonce; Roy M Golsteyn; Bruno Pfeiffer; Michelle Prudhomme
Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.
European journal of pharmacology 2007;554(2-3):106-12.
2007: Ilio Vitale; Lorenzo Galluzzi; Sonia Vivet; Lisa Nanty; Philippe Dessen; Laura Senovilla; Ken A Olaussen; Vladimir Lazar; Michelle Prudhomme; Roy M Golsteyn; Maria Castedo; Guido Kroemer
Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway.
PloS one 2007;2(12):e1337.
2006: Elisabeth Conchon; Bettina Aboab; Roy M Golsteyn; Francisco Cruzalegui; Thomas Edmonds; Stéphane Léonce; Bruno Pfeiffer; Michelle Prudhomme
Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione.
European journal of medicinal chemistry 2006;41(12):1470-7.
2006: Samir Messaoudi; Fabrice Anizon; Paul Peixoto; Marie-Hélène David-Cordonnier; Roy M Golsteyn; Stéphane Léonce; Bruno Pfeiffer; Michelle Prudhomme
Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.
Bioorganic & medicinal chemistry 2006;14(22):7551-62.
2006: Mathieu Sassatelli; Eric Debiton; Bettina Aboab; Michelle Prudhomme; Pascale Moreau
Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties.
European journal of medicinal chemistry 2006;41(6):709-16.
2006: Hélène Hénon; Fabrice Anizon; Roy M Golsteyn; Stéphane Léonce; Robert Hofmann; Bruno Pfeiffer; Michelle Prudhomme
Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions.
Bioorganic & medicinal chemistry 2006;14(11):3825-34.
2006: Michelle Prudhomme
Novel checkpoint 1 inhibitors.
Recent patents on anti-cancer drug discovery 2006;1(1):55-68.
2006: Mathieu Sassatelli; Fadoua Bouchikhi; Samir Messaoudi; Fabrice Anizon; Eric Debiton; Chantal Barthomeuf; Michelle Prudhomme; Pascale Moreau
Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.
European journal of medicinal chemistry 2006;41(1):88-100.
2005: Samir Messaoudi; Fabrice Anizon; Stéphane Léonce; Alain Pierré; Bruno Pfeiffer; Michelle Prudhomme
Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework.
European journal of medicinal chemistry 2005;40(10):961-71.
2005: Pascale Moreau; Susan Holbeck; Michelle Prudhomme; Edward A Sausville
Cytotoxicities of three rebeccamycin derivatives in the National Cancer Institute screening of 60 human tumor cell lines.
Anti-cancer drugs 2005;16(2):145-50.
2004: Samir Messaoudi; Martine Sancelme; Valérie Polard-Housset; Bettina Aboab; Pascale Moreau; Michelle Prudhomme
Synthesis and biological evaluation of oxindoles and benzimidazolinones derivatives.
European journal of medicinal chemistry 2004;39(5):453-8.
2004: Aline Voldoire; Pascale Moreau; Martine Sancelme; Mária Matulová; Stéphane Léonce; Alain Pierré; John Hickman; Bruno Pfeiffer; Pierre Renard; Nathalie Dias; Christian Bailly; Michelle Prudhomme
Analogues of antifungal tjipanazoles from rebeccamycin.
Bioorganic & medicinal chemistry 2004;12(8):1955-62.
2003: Pascale Moreau; Nathalie Gaillard; Christelle Marminon; Fabrice Anizon; Nathalie Dias; Brigitte Baldeyrou; Christian Bailly; Alain Pierré; John Hickman; Bruno Pfeiffer; Pierre Renard; Michelle Prudhomme
Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.
Bioorganic & medicinal chemistry 2003;11(23):4871-9.
2003: Fabrice Anizon; Pascale Moreau; Martine Sancelme; William Laine; Christian Bailly; Michelle Prudhomme
Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety.
Bioorganic & medicinal chemistry 2003;11(17):3709-22.
2003: Christelle Marminon; Alain Pierré; Bruno Pfeiffer; Valérie Pérez; Stéphane Léonce; Pierre Renard; Michelle Prudhomme
Syntheses and antiproliferative activities of rebeccamycin analogues bearing two 7-azaindole moieties.
Bioorganic & medicinal chemistry 2003;11(5):679-87.
2003: Christelle Marminon; Alain Pierré; Bruno Pfeiffer; Valérie Pérez; Stéphane Léonce; Alexandra Joubert; Christian Bailly; Pierre Renard; John Hickman; Michelle Prudhomme
Syntheses and antiproliferative activities of 7-azarebeccamycin analogues bearing one 7-azaindole moiety.
Journal of medicinal chemistry 2003;46(4):609-22.
2002: Michaël Facompré; Brigitte Baldeyrou; Christian Bailly; Fabrice Anizon; Christelle Marminon; Michelle Prudhomme; Pierre Colson; Claude Houssier
DNA targeting of two new antitumour rebeccamycin derivatives.
European journal of medicinal chemistry 2002;37(12):925-32.
2002: Christelle Marminon; Michaël Facompré; Christian Bailly; John Hickman; Alain Pierré; Bruno Pfeiffer; Pierre Renard; Michelle Prudhomme
Dimers from dechlorinated rebeccamycin: synthesis, interaction with DNA, and antiproliferative activities.
European journal of medicinal chemistry 2002;37(5):435-40.
2002: Christelle Marminon; Fabrice Anizon; Pascale Moreau; Stéphane Léonce; Alain Pierré; Bruno Pfeiffer; Pierre Renard; Michelle Prudhomme
Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens.
Journal of medicinal chemistry 2002;45(6):1330-9.
2001: Pascale Moreau; Martine Sancelme; Christian Bailly; Stéphane Léonce; Alain Pierré; John Hickman; Bruno Pfeiffer; Michelle Prudhomme
Synthesis and biological activities of indolocarbazoles bearing amino acid residues.
European journal of medicinal chemistry 2001;36(11-12):887-97.
2001: Aline Voldoire; Martine Sancelme; Michelle Prudhomme; P Colson; Claude Houssier; Christian Bailly; Stéphane Léonce; S Lambel
Rebeccamycin analogues from indolo[2,3-c]carbazole.
Bioorganic & medicinal chemistry 2001;9(2):357-65.
2000: Christian Bailly; Jean-François Goossens; William Laine; Fabrice Anizon; Michelle Prudhomme; J Ren; Jonathan B Chaires
Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA.
Journal of medicinal chemistry 2000;43(24):4711-20.
2000: Jean-François Goossens; Jean-Pierre Hénichart; Fabrice Anizon; Michelle Prudhomme; C Dugave; J Riou; Christian Bailly
Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.
European journal of pharmacology 2000;389(2-3):141-6.
1999: Christian Bailly; Carolina Carrasco; F Hamy; Hervé Vezin; Michelle Prudhomme; A Saleem; E Rubin
The camptothecin-resistant topoisomerase I mutant F361S is cross-resistant to antitumor rebeccamycin derivatives. A model for topoisomerase I inhibition by indolocarbazoles.
Biochemistry 1999;38(27):8605-11.
1999: Pascale Moreau; Fabrice Anizon; Martine Sancelme; Michelle Prudhomme; D Sevère; Jean-François Riou; Jean-François Goossens; Jean-Pierre Hénichart; Christian Bailly; E Labourier; J Tazzi; Doriano Fabbro; T Meyer; AM Aubertin
Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
Journal of medicinal chemistry 1999;42(10):1816-22.
1999: Pascale Moreau; Fabrice Anizon; Martine Sancelme; Michelle Prudhomme; Christian Bailly; D Sevère; Jean-François Riou; Doriano Fabbro; T Meyer; AM Aubertin
Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
Journal of medicinal chemistry 1999;42(4):584-92.
1999: Christian Bailly; Xiaogang Qu; Fabrice Anizon; Michelle Prudhomme; Jean-François Riou; Jonathan B Chaires
Enhanced binding to DNA and topoisomerase I inhibition by an analog of the antitumor antibiotic rebeccamycin containing an amino sugar residue.
Molecular pharmacology 1999;55(2):377-85.
1999: E Labourier; Jean-François Riou; Michelle Prudhomme; C Carrasco; Christian Bailly; Jamal Tazi
Poisoning of topoisomerase I by an antitumor indolocarbazole drug: stabilization of topoisomerase I-DNA covalent complexes and specific inhibition of the protein kinase activity.
Cancer research 1999;59(1):52-5.
1998: Fabrice Anizon; Pascale Moreau; Martine Sancelme; Aline Voldoire; Michelle Prudhomme; M Ollier; D Sevère; Jean-François Riou; Christian Bailly; Doriano Fabbro; T Meyer; AM Aubertin
Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin.
Bioorganic & medicinal chemistry 1998;6(9):1597-604.
1998: Pascale Moreau; Fabrice Anizon; Martine Sancelme; Michelle Prudhomme; Christian Bailly; C Carrasco; M Ollier; D Sevère; Jean-François Riou; Doriano Fabbro; T Meyer; AM Aubertin
Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
Journal of medicinal chemistry 1998;41(10):1631-40.
1997: Fabrice Anizon; L Belin; Pascale Moreau; Martine Sancelme; Aline Voldoire; Michelle Prudhomme; M Ollier; D Sevère; Jean-François Riou; Christian Bailly; Doriano Fabbro; T Meyer
Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
Journal of medicinal chemistry 1997;40(21):3456-65.
1997: E R Pereira; Michelle Prudhomme; Martine Sancelme; M Ollier; D Severe; Jean-François Riou; Huguette Crevel; Jean-Pierre Savineau; Doriano Fabbro; T Meyer
Synthesis and biological evaluation of monoindolyl and indolocarbazolyl oxazolones and imidazolones.
Chemical & pharmaceutical bulletin 1997;45(4):733-6.