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Ger Pruijn

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Chemicals & Drugs

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Rheumatoid Arthritis

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Sanne M M Hensen; Ger J M Pruijn; Chrissy M W van Enckevort; Siebe T van Genesen; Lonneke Heldens; Nicolette H Lubsen
Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels.
Katherine E Sloan; David Tollervey; Simon Lebaron; Sandy Mattijssen; Ger J M Pruijn; Nicholas J Watkins
Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing.
H Pluk; Snjolaug Arnardottir; Umesh A Badrising; Wilbert C Boelens; Karina Gheorghe; Ingrid E Lundberg; H Jurgen Schelhaas; Judith Stammen-Vogelzangs; Annemarie van der Heijden; Sander H J van Dooren; Baziel G van Engelen; Bas J A van Hoeve; Marcel M Verbeek; Ger J M Pruijn
Autoantibodies to cytosolic 5'-nucleotidase 1A in inclusion body myositis.

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2013: Sanne M M Hensen; Ger J M Pruijn; Chrissy M W van Enckevort; Siebe T van Genesen; Lonneke Heldens; Nicolette H Lubsen
Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels.
Biochimie 2013;95(6):1245-51.
2013: Katherine E Sloan; David Tollervey; Simon Lebaron; Sandy Mattijssen; Ger J M Pruijn; Nicholas J Watkins
Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing.
The Journal of cell biology 2013;200(5):577-88.
2013: H Pluk; Snjolaug Arnardottir; Umesh A Badrising; Wilbert C Boelens; Karina Gheorghe; Ingrid E Lundberg; H Jurgen Schelhaas; Judith Stammen-Vogelzangs; Annemarie van der Heijden; Sander H J van Dooren; Baziel G van Engelen; Bas J A van Hoeve; Marcel M Verbeek; Ger J M Pruijn
Autoantibodies to cytosolic 5'-nucleotidase 1A in inclusion body myositis.
Annals of neurology 2013;73(3):397-407.
2013: Joyce J B C van Beers; Albert J W Zendman; Reinout Raijmakers; Judith Stammen-Vogelzangs; Ger J M Pruijn
Peptidylarginine deiminase expression and activity in PAD2 knock-out and PAD4-low mice.
Biochimie 2013;95(2):299-308.
2013: Joyce J B C van Beers; Borut Bozic; Els Oosterink; Carla M Schwarte; Judith Stammen-Vogelzangs; Ger J M Pruijn
The rheumatoid arthritis synovial fluid citrullinome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and β-actin.
Arthritis and rheumatism 2013;65(1):69-80.
2012: Sanne M M Hensen; Ger J M Pruijn; Chrissy M W van Enckevort; Siebe T van Genesen; Lonneke Heldens; Nicolette H Lubsen
Heat shock factor 1 is inactivated by amino acid deprivation.
Cell stress & chaperones 2012;17(6):743-55.
2012: Remon van Geel; Marjoke F Debets; Dennis W P M Löwik; Ger J M Pruijn; Wilbert C Boelens
Detection of transglutaminase activity using click chemistry.
Amino acids 2012;43(3):1251-63.
2012: Sandy Mattijssen; Ger J M Pruijn
Viperin, a key player in the antiviral response.
Microbes and infection / Institut Pasteur 2012;14(5):419-26.
2012: Remon van Geel; Ger J M Pruijn; Floris L van Delft; Wilbert C Boelens
Preventing thiol-yne addition improves the specificity of strain-promoted azide-alkyne cycloaddition.
Bioconjugate chemistry 2012;23(3):392-8.
2012: Dewi Astuti; Trevor Cole; Wendy N Cooper; Graham A Fews; Dean Gentle; Harmeet Gill; Farida Latif; Mark Morris; Ferenc Müller; Giovanni Neri; John M Opitz; Ger J M Pruijn; Christopher J Ricketts; Patrick Rump; Salwati Shuib; Raymond H J Staals; Irene Stolte-Dijkstra; Anthonie J van Essen; Richard A van Lingen; Naomi C Wake; Eamonn R Maher
Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility.
Nature genetics 2012;44(3):277-84.
2012: Reinout Raijmakers; Joyce J B C van Beers; Natasja F C Visser; Borut Bozic; Mahmoud El-Azzouny; Ger J M Pruijn; Albert J R Heck
Elevated levels of fibrinogen-derived endogenous citrullinated peptides in synovial fluid of rheumatoid arthritis patients.
Arthritis research & therapy 2012;14(3):R114.
2011: Sander H J van Dooren; Walther J van Venrooij; Reinout Raijmakers; Richelle E C Spanjers; Wilbert C Boelens; Albert J R Heck; Tom S Koemans; Angelique M C Lokate; H Pluk; Ger J M Pruijn
Oxidative stress-induced modifications of histidyl-tRNA synthetase affect its tRNA aminoacylation activity but not its immunoreactivity.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2011;89(6):545-53.
2011: Anja P M Verhagen; Ger J M Pruijn
Are the Ro RNP-associated Y RNAs concealing microRNAs? Y RNA-derived miRNAs may be involved in autoimmunity.
BioEssays : news and reviews in molecular, cellular and developmental biology 2011;33(9):674-82.
2011: Walther J van Venrooij; Joyce J B C van Beers; Ger J M Pruijn
Anti-CCP antibodies: the past, the present and the future.
Nature reviews. Rheumatology 2011;7(7):391-8.
2011: Sandy Mattijssen; Carla Onnekink; Peter Cresswell; Pia Hermanns; Ella R Hinson; Bernhard Zabel; Ger J M Pruijn
Viperin mRNA is a novel target for the human RNase MRP/RNase P endoribonuclease.
Cellular and molecular life sciences : CMLS 2011;68(14):2469-80.
2011: Raymond H J Staals; Ger J M Pruijn
The human exosome and disease.
Advances in experimental medicine and biology 2011;702():132-42.
2011: Lotte A van de Stadt; Ann R van der Horst; M H M T de Koning; Wouter H Bos; Gertjan Wolbink; Rob J van de Stadt; Ger J M Pruijn; Ben A C Dijkmans; Dirkjan van Schaardenburg; Dörte Hamann
The extent of the anti-citrullinated protein antibody repertoire is associated with arthritis development in patients with seropositive arthralgia.
Annals of the rheumatic diseases 2011;70(1):128-33.
2010: Allan S Wiik; Walther J van Venrooij; Ger J M Pruijn
All you wanted to know about anti-CCP but were afraid to ask.
Autoimmunity reviews 2010;10(2):90-3.
2010: Diane van der Woude; Solbritt Rantapää-Dahlqvist; Andreea Ioan-Facsinay; Carla Onnekink; Carla M Schwarte; Kirsten N Verpoort; Jan Wouter Drijfhout; Tom W J Huizinga; René E M Toes; Ger J M Pruijn
Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis.
Annals of the rheumatic diseases 2010;69(8):1554-61.
2010: Raymond H J Staals; Alfred W Bronkhorst; Geurt Schilders; Shimyn Slomovic; Gadi Schuster; Albert J R Heck; Reinout Raijmakers; Ger J M Pruijn
Dis3-like 1: a novel exoribonuclease associated with the human exosome.
The EMBO journal 2010;29(14):2358-67.
2010: Sandy Mattijssen; Tim J M Welting; Ger J M Pruijn
RNase MRP and disease.
Wiley interdisciplinary reviews. RNA 2010;1(1):102-16.
2010: Katherine L D Hands-Taylor; Luigi Martino; Renée Tata; Jeffrey J Babon; Tam T. T. Bui; Alex F Drake; Rebecca L Beavil; Ger J M Pruijn; Paul R Brown; Maria R Conte
Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA.
Nucleic acids research 2010;38(12):4052-66.
2010: Raymond H J Staals; Ger J M Pruijn
The human exosome and disease.
Advances in experimental medicine and biology 2010;702():132-42.
2010: Joyce J B C van Beers; Reinout Raijmakers; Lou-Ella Alexander; Judith Stammen-Vogelzangs; Angelique M C Lokate; Albert J R Heck; Richard B M Schasfoort; Ger J M Pruijn
Mapping of citrullinated fibrinogen B-cell epitopes in rheumatoid arthritis by imaging surface plasmon resonance.
Arthritis research & therapy 2010;12(6):R219.
2008: Tim J M Welting; Sandy Mattijssen; Florence M A Peters; Nienke L van Doorn; Lianne Dekkers; Walther J van Venrooij; Hans A Heus; Luisa Bonafé; Ger J M Pruijn
Cartilage-hair hypoplasia-associated mutations in the RNase MRP P3 domain affect RNA folding and ribonucleoprotein assembly.
Biochimica et biophysica acta 2008;1783(3):455-66.
2008: J Bianca Beusink; Angelique M C Lokate; Geert A J Besselink; Ger J M Pruijn; Richard B M Schasfoort
Angle-scanning SPR imaging for detection of biomolecular interactions on microarrays.
Biosensors & bioelectronics 2008;23(6):839-44.
2008: Geurt Schilders; Ger J M Pruijn
Biochemical studies of the mammalian exosome with intact cells.
Methods in enzymology 2008;448():211-26.
2007: Kirsten N Verpoort; K Cheung; Andreea Ioan-Facsinay; Annette H M Van Der Helm-Van Mil; Jeska K de Vries-Bouwstra; Cornelia F Allaart; Jan Wouter Drijfhout; René R P De Vries; Ferdinand C Breedveld; Tom W J Huizinga; Ger J M Pruijn; René E M Toes
Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles.
Arthritis and rheumatism 2007;56(12):3949-52.
2007: Eiji Nakashima; Joseph R Tran; Tim J M Welting; Ger J M Pruijn; Yuichiro Hirose; Gen Nishimura; Hirofumi Ohashi; Shepherd H Schurman; Jun Cheng; Fabio Candotti; Ramaiah Nagaraja; Shiro Ikegawa; David Schlessinger
Cartilage hair hypoplasia mutations that lead to RMRP promoter inefficiency or RNA transcript instability.
American journal of medical genetics. Part A 2007;143A(22):2675-81.
2007: Angelique M C Lokate; J Bianca Beusink; Geert A J Besselink; Ger J M Pruijn; Richard B M Schasfoort
Biomolecular interaction monitoring of autoantibodies by scanning surface plasmon resonance microarray imaging.
Journal of the American Chemical Society 2007;129(45):14013-8.
2007: Albert J W Zendman; Reinout Raijmakers; Suzanne Nijenhuis; Erik R Vossenaar; Marloes van den Tillaart; Renato G S Chirivi; Jos M H Raats; Walther J van Venrooij; Jan Wouter Drijfhout; Ger J M Pruijn
ABAP: antibody-based assay for peptidylarginine deiminase activity.
Analytical biochemistry 2007;369(2):232-40.
2007: Geurt Schilders; Wilma Vree Egberts; Reinout Raijmakers; Ger J M Pruijn
C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome.
Arthritis and rheumatism 2007;56(7):2449-54.
2007: Erwin van Dijk; Geurt Schilders; Ger J M Pruijn
Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.
RNA (New York, N.Y.) 2007;13(7):1027-35.
2007: Reinout Raijmakers; Albert J W Zendman; Wilma Vree Egberts; Erik R Vossenaar; Jos M H Raats; Claudia Soede-Huijbregts; Floris P J T Rutjes; Peter A van Veelen; Jan Wouter Drijfhout; Ger J M Pruijn
Methylation of arginine residues interferes with citrullination by peptidylarginine deiminases in vitro.
Journal of molecular biology 2007;367(4):1118-29.
2007: Antonio Vannini; K Cheung; Marco Fusconi; J Stammen-Vogelzangs; Joost P H Drenth; Anna Chiara Dall'aglio; Francesco B Bianchi; L E Bakker-Jonges; Walther J van Venrooij; Ger J M Pruijn; Albert J W Zendman
Anti-cyclic citrullinated peptide positivity in non-rheumatoid arthritis disease samples: citrulline-dependent or not?
Annals of the rheumatic diseases 2007;66(4):511-6.
2007: Geurt Schilders; Erwin van Dijk; Ger J M Pruijn
C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing.
Nucleic acids research 2007;35(8):2564-72.
2007: Geurt Schilders; Reinout Raijmakers; Kelen C R Malmegrim; Lieselotte Vande Walle; Xavier Saelens; W T M Vree Egberts; Walther J van Venrooij; Peter Vandenabeele; Ger J M Pruijn
Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis.
Arthritis research & therapy 2007;9(1):R12.
2007: Tim J M Welting; Florence M A Peters; Sanne M M Hensen; Nienke L van Doorn; Bastiaan J Kikkert; Jos M H Raats; Walther J van Venrooij; Ger J M Pruijn
Heterodimerization regulates RNase MRP/RNase P association, localization, and expression of Rpp20 and Rpp25.
RNA (New York, N.Y.) 2007;13(1):65-75.
2006: Walther J van Venrooij; Albert J W Zendman; Ger J M Pruijn
Autoantibodies to citrullinated antigens in (early) rheumatoid arthritis.
Autoimmunity reviews 2006;6(1):37-41.
2006: Reinout Raijmakers; Judith Vogelzangs; Jos M H Raats; Maret Panzenbeck; Maureen Corby; Huiping Jiang; Michael Thibodeau; Nancy Haynes; Walther J van Venrooij; Ger J M Pruijn; Brian Werneburg
Experimental autoimmune encephalomyelitis induction in peptidylarginine deiminase 2 knockout mice.
The Journal of comparative neurology 2006;498(2):217-26.
2006: Tim J M Welting; Bastiaan J Kikkert; Walther J van Venrooij; Ger J M Pruijn
Differential association of protein subunits with the human RNase MRP and RNase P complexes.
RNA (New York, N.Y.) 2006;12(7):1373-82.
2006: Daniëlle Hof; Kalok Cheung; Hilde E Roossien; Ger J M Pruijn; Jos M H Raats
A novel subtractive antibody phage display method to discover disease markers.
Molecular & cellular proteomics : MCP 2006;5(2):245-55.
2006: Geurt Schilders; Erwin van Dijk; Reinout Raijmakers; Ger J M Pruijn
Cell and molecular biology of the exosome: how to make or break an RNA.
International review of cytology 2006;251():159-208.
2006: Ger J M Pruijn
The RNA interference pathway: a new target for autoimmunity.
Arthritis research & therapy 2006;8(4):110.
2006: Albert J W Zendman; Walther J van Venrooij; Ger J M Pruijn
Use and significance of anti-CCP autoantibodies in rheumatoid arthritis.
Rheumatology (Oxford, England) 2006;45(1):20-5.
2005: Daniëlle Hof; Jos M H Raats; Ger J M Pruijn
Apoptotic modifications affect the autoreactivity of the U1 snRNP autoantigen.
Autoimmunity reviews 2005;4(6):380-8.
2005: Ger J M Pruijn
Doughnuts dealing with RNA.
Nature structural & molecular biology 2005;12(7):562-4.
2005: Reinout Raijmakers; Judith Vogelzangs; J. Ludovic Croxford; Pieter Wesseling; Walther J van Venrooij; Ger J M Pruijn
Citrullination of central nervous system proteins during the development of experimental autoimmune encephalomyelitis.
The Journal of comparative neurology 2005;486(3):243-53.
2005: Geurt Schilders; Reinout Raijmakers; Jos M H Raats; Ger J M Pruijn
MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation.
Nucleic acids research 2005;33(21):6795-804.
2005: Daniëlle Hof; Kalok Cheung; Dirk-Jan R A M de Rooij; F H J van den Hoogen; Ger J M Pruijn; Walther J van Venrooij; Jos M H Raats
Autoantibodies specific for apoptotic U1-70K are superior serological markers for mixed connective tissue disease.
Arthritis research & therapy 2005;7(2):R302-9.
2004: Suzanne Nijenhuis; Albert J W Zendman; Erik R Vossenaar; Ger J M Pruijn; Walther J vanVenrooij
Autoantibodies to citrullinated proteins in rheumatoid arthritis: clinical performance and biochemical aspects of an RA-specific marker.
Clinica chimica acta; international journal of clinical chemistry 2004;350(1-2):17-34.
2004: Sander Granneman; Judith Vogelzangs; Reinhard Lührmann; Walther J van Venrooij; Ger J M Pruijn; Nicholas J Watkins
Role of pre-rRNA base pairing and 80S complex formation in subnucleolar localization of the U3 snoRNP.
Molecular and cellular biology 2004;24(19):8600-10.
2004: Reinout Raijmakers; Geurt Schilders; Ger J M Pruijn
The exosome, a molecular machine for controlled RNA degradation in both nucleus and cytoplasm.
European journal of cell biology 2004;83(5):175-83.
2004: Reinout Raijmakers; Manfred Renz; Claudia Wiemann; Wilma Vree Egberts; Hans Peter Seelig; Walther J van Venrooij; Ger J M Pruijn
PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome.
Arthritis and rheumatism 2004;50(2):565-9.
2004: Michael A Fouraux; Magdalena Deneka; Viorica Ivan; Annemarie van der Heijden; Jos Raymackers; Denise van Suylekom; Walther J van Venrooij; Peter van Der Sluijs; Ger J M Pruijn
Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes.
Molecular biology of the cell 2004;15(2):611-24.
2004: Tim J M Welting; Walther J van Venrooij; Ger J M Pruijn
Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.
Nucleic acids research 2004;32(7):2138-46.
2003: Erik R Vossenaar; Albert J W Zendman; Walther J van Venrooij; Ger J M Pruijn
PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease.
BioEssays : news and reviews in molecular, cellular and developmental biology 2003;25(11):1106-18.
2003: Tim J M Welting; Reinout Raijmakers; Ger J M Pruijn
Autoantigenicity of nucleolar complexes.
Autoimmunity reviews 2003;2(6):313-21.
2003: Reinout Raijmakers; Wilma Vree Egberts; Walther J van Venrooij; Ger J M Pruijn
The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus.
The Journal of biological chemistry 2003;278(33):30698-704.
2003: Jos M H Raats; Eveline M Wijnen; Ger J M Pruijn; F H J van den Hoogen; Walther J van Venrooij
Recombinant human monoclonal autoantibodies specific for citrulline-containing peptides from phage display libraries derived from patients with rheumatoid arthritis.
The Journal of rheumatology 2003;30(8):1696-711.
2003: K C R Malmegrim de Farias; Xavier Saelens; Ger J M Pruijn; Peter Vandenabeele; Walther J van Venrooij
Caspase-mediated cleavage of the U snRNP-associated Sm-F protein during apoptosis.
Cell death and differentiation 2003;10(5):570-9.
2003: Sander Granneman; Jennifer E G Gallagher; Judith Vogelzangs; Wendy Horstman; Walther J van Venrooij; Susan J. Baserga; Ger J M Pruijn
The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes.
Nucleic acids research 2003;31(7):1877-87.
2003: Jos M H Raats; Will Roeffen; Sandy Litjens; Ibrahim Bulduk; Gijs Mans; Walther J van Venrooij; Ger J M Pruijn
Human recombinant anti-La (SS-B) autoantibodies demonstrate the accumulation of phosphoserine-366-containing la isoforms in nucleoplasmic speckles.
European journal of cell biology 2003;82(3):131-41.
2003: Jos M H Raats; Nicole van Bree; Jochem van Woezik; Ger J M Pruijn
Generating recombinant anti-idiotypic antibodies for the detection of haptens in solution.
Journal of immunoassay & immunochemistry 2003;24(2):115-46.
2002: Sander Granneman; Ger J M Pruijn; Wendy Horstman; Walther J van Venrooij; Reinhard Luhrmann; Nicholas J Watkins
The hU3-55K protein requires 15.5K binding to the box B/C motif as well as flanking RNA elements for its association with the U3 small nucleolar RNA in Vitro.
The Journal of biological chemistry 2002;277(50):48490-500.
2002: Hans Van Eenennaam; Judith Vogelzangs; Dorien Lugtenberg; F H J van den Hoogen; Walther J van Venrooij; Ger J M Pruijn
Identity of the RNase MRP- and RNase P-associated Th/To autoantigen.
Arthritis and rheumatism 2002;46(12):3266-72.
2002: Hans Van Eenennaam; Judith Vogelzangs; L Bisschops; L C J Te Boome; Hans Peter Seelig; Manfred Renz; D-J De Rooij; Rick Brouwer; H Pluk; Ger J M Pruijn; Walther J van Venrooij; F H J van den Hoogen
Autoantibodies against small nucleolar ribonucleoprotein complexes and their clinical associations.
Clinical and experimental immunology 2002;130(3):532-40.
2002: Michael A Fouraux; Marloes J M Kolkman; Annemarie van der Heijden; Arjan S de Jong; Walther J van Venrooij; Ger J M Pruijn
The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase.
RNA (New York, N.Y.) 2002;8(11):1428-43.
2002: Reinout Raijmakers; Wilma Vree Egberts; Walther J van Venrooij; Ger J M Pruijn
Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
Journal of molecular biology 2002;323(4):653-63.
2002: Kelen C R Malmegrim; Ger J M Pruijn; Walther J van Venrooij
The fate of the U1 snRNP autoantigen during apoptosis: implications for systemic autoimmunity.
The Israel Medical Association journal : IMAJ 2002;4(9):706-12.
2002: Michael A Fouraux; Philippe Bouvet; Sjoerd Verkaart; Walther J van Venrooij; Ger J M Pruijn
Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes.
Journal of molecular biology 2002;320(3):475-88.
2002: Michael A Fouraux; Annemarie van der Heijden; Walther J van Venrooij; Ger J M Pruijn
Cross-reactivity of the anti-La monoclonal antibody SW5 with early endosome antigen 2.
Immunology 2002;106(3):336-42.
2002: Reinout Raijmakers; Yvet E Noordman; Walther J van Venrooij; Ger J M Pruijn
Protein-protein interactions of hCsl4p with other human exosome subunits.
Journal of molecular biology 2002;315(4):809-18.
2002: Devi Mukherjee; Min Gao; J Patrick O'Connor; Reinout Raijmakers; Ger J M Pruijn; Carol S Lutz; Jeffrey Wilusz
The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements.
The EMBO journal 2002;21(1-2):165-74.
2002: Rick Brouwer; W T M Vree Egberts; Gerald J D Hengstman; Reinout Raijmakers; B G M van Engelen; Hans Peter Seelig; Manfred Renz; Rudolf Mierau; Ekkehard Genth; Ger J M Pruijn; Walther J van Venrooij
Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.
Arthritis research 2002;4(2):134-8.
2001: Hans Van Eenennaam; Annemarie van der Heijden; R J Janssen; Walther J van Venrooij; Ger J M Pruijn
Basic domains target protein subunits of the RNase MRP complex to the nucleolus independently of complex association.
Molecular biology of the cell 2001;12(11):3680-9.
2001: Hans Van Eenennaam; D Lugtenberg; Judith Vogelzangs; Walther J van Venrooij; Ger J M Pruijn
hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases.
The Journal of biological chemistry 2001;276(34):31635-41.
2001: G Fabini; Reinout Raijmakers; Silvia Hayer; Michael A Fouraux; Ger J M Pruijn; Günter Steiner
The heterogeneous nuclear ribonucleoproteins I and K interact with a subset of the ro ribonucleoprotein-associated Y RNAs in vitro and in vivo.
The Journal of biological chemistry 2001;276(23):20711-8.
2001: SA Rutjes; E Lund; Annemarie van der Heijden; Christian grimm, Prof Dr. Phil. Nat.; Walther J van Venrooij; Ger J M Pruijn
Identification of a novel cis-acting RNA element involved in nuclear export of hY RNAs.
RNA (New York, N.Y.) 2001;7(5):741-52.
2001: Rick Brouwer; Christine Allmang; Reinout Raijmakers; Yvonne Van Aarssen; Wilma Vree Egberts; Elisabeth Petfalski; Walther J van Venrooij; David Tollervey; Ger J M Pruijn
Three novel components of the human exosome.
The Journal of biological chemistry 2001;276(9):6177-84.
2001: Rainer Seidl; O Labudova; Kurt Krapfenbauer; E W Henriksson; J Craft; D Turhani-Schatzmann; T Achsel; Bettina Bidmon; Ger J M Pruijn; Nigel J Cairns; Gert Lubec
Deficient brain snRNP70K in patients with Down syndrome.
Electrophoresis 2001;22(1):43-8.
2001: Rick Brouwer; Ger J M Pruijn; Walther J van Venrooij
The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma.
Arthritis research 2001;3(2):102-6.
2000: WG Degen; Ger J M Pruijn; Jos M H Raats; Walther J van Venrooij
Caspase-dependent cleavage of nucleic acids.
Cell death and differentiation 2000;7(7):616-27.
2000: R J Rodenburg; Jos M H Raats; Ger J M Pruijn; Walther J van Venrooij
Cell death: a trigger of autoimmunity?
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(7):627-36.
2000: G Fabini; SA Rutjes; C Zimmermann; Ger J M Pruijn; Günter Steiner
Analysis of the molecular composition of Ro ribonucleoprotein complexes. Identification of novel Y RNA-binding proteins.
European journal of biochemistry / FEBS 2000;267(9):2778-89.
2000: Hans Van Eenennaam; N Jarrous; Walther J van Venrooij; Ger J M Pruijn
Architecture and function of the human endonucleases RNase P and RNase MRP.
IUBMB life 2000;49(4):265-72.
2000: C H Broekhuis; G Neubauer; Annemarie van der Heijden; M Mann; C G Proud; Walther J van Venrooij; Ger J M Pruijn
Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution.
Biochemistry 2000;39(11):3023-33.
2000: SW Teunissen; M J Kruithof; A Darise Farris; John B Harley; W J Venrooij; Ger J M Pruijn
Conserved features of Y RNAs: a comparison of experimentally derived secondary structures.
Nucleic acids research 2000;28(2):610-9.
2000: Walther J van Venrooij; Ger J M Pruijn
Citrullination: a small change for a protein with great consequences for rheumatoid arthritis.
Arthritis research 2000;2(4):249-51.
2000: WG Degen; Y Aarssen; Ger J M Pruijn; PJ Utz; Walther J van Venrooij
The fate of U1 snRNP during anti-Fas induced apoptosis: specific cleavage of the U1 snRNA molecule.
Cell death and differentiation 2000;7(1):70-9.
1999: M C James; Ian W Jeffrey; Ger J M Pruijn; JP Thijssen; Michael J Clemens
Translational control by the La antigen. Structure requirements for rescue of the double-stranded RNA-mediated inhibition of protein synthesis.
European journal of biochemistry / FEBS 1999;266(1):151-62.
1999: SA Rutjes; PJ Utz; Annemarie van der Heijden; C Broekhuis; Walther J van Venrooij; Ger J M Pruijn
The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis.
Cell death and differentiation 1999;6(10):976-86.
1999: René M A Hoet; Martijn Pieffers; M H Stassen; Jos M H Raats; Ruud M T de Wildt; Ger J M Pruijn; F Van Den Hoogen; Walther J van Venrooij
The importance of the light chain for the epitope specificity of human anti-U1 small nuclear RNA autoantibodies present in systemic lupus erythematosus patients.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3304-12.
1999: SA Rutjes; Annemarie van der Heijden; PJ Utz; Walther J van Venrooij; Ger J M Pruijn
Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis.
The Journal of biological chemistry 1999;274(35):24799-807.
1999: Hans Van Eenennaam; Ger J M Pruijn; Walther J van Venrooij
hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes.
Nucleic acids research 1999;27(12):2465-72.
1999: H Pluk; Hans Van Eenennaam; SA Rutjes; Ger J M Pruijn; Walther J van Venrooij
RNA-protein interactions in the human RNase MRP ribonucleoprotein complex.
RNA (New York, N.Y.) 1999;5(4):512-24.
1999: A Darise Farris; G Koelsch; Ger J M Pruijn; Walther J van Venrooij; John B Harley
Conserved features of Y RNAs revealed by automated phylogenetic secondary structure analysis.
Nucleic acids research 1999;27(4):1070-8.
1998: SW Teunissen; M H Stassen; Ger J M Pruijn; Walther J van Venrooij; René M A Hoet
Characterization of an anti-RNA recombinant autoantibody fragment (scFv) isolated from a phage display library and detailed analysis of its binding site on U1 snRNA.
RNA (New York, N.Y.) 1998;4(9):1124-33.
1997: M Schmitz; Michael Bachmann; J Laübinger; JP Thijssen; Ger J M Pruijn
Characterization of murine monoclonal antibodies against the Ro52 autoantigen.
Clinical and experimental immunology 1997;110(1):53-62.
1997: Ger J M Pruijn; F H Simons; Walther J van Venrooij
Intracellular localization and nucleocytoplasmic transport of Ro RNP components.
European journal of cell biology 1997;74(2):123-32.
1997: JM Klein Gunnewiek; Yvonne Van Aarssen; Annemiete W C M van der Kemp; R Nelissen; Ger J M Pruijn; Walther J van Venrooij
Nuclear accumulation of the U1 snRNP-specific protein C is due to diffusion and retention in the nucleus.
Experimental cell research 1997;235(1):265-73.
1997: SA Rutjes; W T M Vree Egberts; P J H Jongen; F Van Den Hoogen; Ger J M Pruijn; Walther J van Venrooij
Anti-Ro52 antibodies frequently co-occur with anti-Jo-1 antibodies in sera from patients with idiopathic inflammatory myopathy.
Clinical and experimental immunology 1997;109(1):32-40.
1997: V Ricchiuti; Ger J M Pruijn; JP Thijssen; Walther J van Venrooij; Sylviane Muller
Accessibility of epitopes on the 52-kD Ro/SSA protein (Ro52) and on the RoRNP associated Ro52 protein as determined by anti-peptide antibodies.
Journal of autoimmunity 1997;10(2):181-91.
1997: Ger J M Pruijn; F Schoute; JP Thijssen; R J Smeenk; Walther J van Venrooij
Mapping of SLE-specific Sm B cell epitopes using murine monoclonal antibodies.
Journal of autoimmunity 1997;10(2):127-36.
1997: P Hühn; Ger J M Pruijn; W J van Venrooij; Michael Bachmann
Characterization of the autoantigen La (SS-B) as a dsRNA unwinding enzyme.
Nucleic acids research 1997;25(2):410-6.
1996: F H Simons; F J Broers; Walther J van Venrooij; Ger J M Pruijn
Characterization of cis-acting signals for nuclear import and retention of the La (SS-B) autoantigen.
Experimental cell research 1996;224(2):224-36.
1996: R Peek; Ger J M Pruijn; Walther J van Venrooij
Interaction of the La (SS-B) autoantigen with small ribosomal subunits.
European journal of biochemistry / FEBS 1996;236(2):649-55.
1996: F H Simons; SA Rutjes; Walther J van Venrooij; Ger J M Pruijn
The interactions with Ro60 and La differentially affect nuclear export of hY1 RNA.
RNA (New York, N.Y.) 1996;2(3):264-73.
1995: H Tröster; Holger Bartsch; R Klein; T E Metzger; G Pollak; Imre Semsei; Martin Schwemmle; Ger J M Pruijn; W J van Venrooij; Michael Bachmann
Activation of a murine autoreactive B cell by immunization with human recombinant autoantigen La/SS-B: characterization of the autoepitope.
Journal of autoimmunity 1995;8(6):825-42.
1995: Walther J van Venrooij; Ger J M Pruijn
Ribonucleoprotein complexes as autoantigens.
Current opinion in immunology 1995;7(6):819-24.
1995: Ger J M Pruijn; JP Thijssen; P R Smith; david williams; Walther J van Venrooij
Anti-La monoclonal antibodies recognizing epitopes within the RNA-binding domain of the La protein show differential capacities to immunoprecipitate RNA-associated La protein.
European journal of biochemistry / FEBS 1995;232(2):611-9.
1995: C H Veldhoven; Ger J M Pruijn; J F Meilof; JP Thijssen; Annemiete W C M van der Kemp; Walther J van Venrooij; RJ Smeenk
Characterization of murine monoclonal antibodies against 60-kD Ro/SS-A and La/SS-B autoantigens.
Clinical and experimental immunology 1995;101(1):45-54.
1995: M C James; Ger J M Pruijn; W J van Venrooij; Michael J Clemens
Analysis of the double-stranded RNA binding properties of the La antigen.
Biochemical Society transactions 1995;23(2):312S.
1995: Y Misaki; Walther J van Venrooij; Ger J M Pruijn
Prevalence and characteristics of anti-56K/annexin XI autoantibodies in systemic autoimmune diseases.
The Journal of rheumatology 1995;22(1):97-102.
1994: R Peek; Walther J van Venrooij; F Simons; Ger J M Pruijn
The SS-A/SS-B autoantigenic complex: localization and assembly.
Clinical and experimental rheumatology 1994;12 Suppl 11():S15-8.
1994: R Peek; Ger J M Pruijn; Walther J van Venrooij
Epitope specificity determines the ability of anti-Ro52 autoantibodies to precipitate Ro ribonucleoprotein particles.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(9):4321-9.
1994: C W van Gelder; JP Thijssen; E C Klaassen; C Sturchler; Alain Krol; Walther J van Venrooij; Ger J M Pruijn
Common structural features of the Ro RNP associated hY1 and hY5 RNAs.
Nucleic acids research 1994;22(13):2498-506.
1994: Q Xiao; T V Sharp; I W Jeffrey; M C James; Ger J M Pruijn; W J van Venrooij; Michael J Clemens
The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA.
Nucleic acids research 1994;22(13):2512-8.
1994: F H Simons; Ger J M Pruijn; Walther J van Venrooij
Analysis of the intracellular localization and assembly of Ro ribonucleoprotein particles by microinjection into Xenopus laevis oocytes.
The Journal of cell biology 1994;125(5):981-8.
1994: R Peek; J R Westphal; Ger J M Pruijn; A J Van der Kemp; Walther J van Venrooij
Adenovirus infection induces loss of HLA class I and CD3 antigens, but does not induce cell surface presentation of the La (SS-B) autoantigen.
Clinical and experimental immunology 1994;96(3):395-402.
1994: V Ricchiuti; Jean-Paul Briand; O Meyer; D A Isenberg; Ger J M Pruijn; S Muller
Epitope mapping with synthetic peptides of 52-kD SSA/Ro protein reveals heterogeneous antibody profiles in human autoimmune sera.
Clinical and experimental immunology 1994;95(3):397-407.
1994: Y Misaki; Ger J M Pruijn; Annemiete W C M van der Kemp; Walther J van Venrooij
The 56K autoantigen is identical to human annexin XI.
The Journal of biological chemistry 1994;269(6):4240-6.
1993: Ger J M Pruijn; P A Wingens; S L Peters; JP Thijssen; Walther J van Venrooij
Ro RNP associated Y RNAs are highly conserved among mammals.
Biochimica et biophysica acta 1993;1216(3):395-401.
1993: Borut Bozic; Ger J M Pruijn; Blaz Rozman; Walther J van Venrooij
Sera from patients with rheumatic diseases recognize different epitope regions on the 52-kD Ro/SS-A protein.
Clinical and experimental immunology 1993;94(2):227-35.
1993: R Peek; Ger J M Pruijn; A J van der Kemp; Walther J van Venrooij
Subcellular distribution of Ro ribonucleoprotein complexes and their constituents.
Journal of cell science 1993;106 ( Pt 3)():929-35.
1993: Walther J van Venrooij; R L Slobbe; Ger J M Pruijn
Structure and function of La and Ro RNPs.
Molecular biology reports 1993;18(2):113-9.
1992: R L Slobbe; W Pluk; Walther J van Venrooij; Ger J M Pruijn
Ro ribonucleoprotein assembly in vitro. Identification of RNA-protein and protein-protein interactions.
Journal of molecular biology 1992;227(2):361-6.
1992: Ger J M Pruijn; Borut Bozic; F Schoute; L A Rokeach; Walther J van Venrooij
Refined definition of the 56K and other autoantigens in the 50-60 kDa region.
Molecular biology reports 1992;16(4):267-76.
1991: Ger J M Pruijn; R L Slobbe; Walther J van Venrooij
Analysis of protein--RNA interactions within Ro ribonucleoprotein complexes.
Nucleic acids research 1991;19(19):5173-80.
1991: R L Slobbe; Ger J M Pruijn; W G Damen; J W van der Kemp; Walther J van Venrooij
Detection and occurrence of the 60- and 52-kD Ro (SS-A) antigens and of autoantibodies against these proteins.
Clinical and experimental immunology 1991;86(1):99-105.
1991: R L Slobbe; Ger J M Pruijn; Walther J van Venrooij
Ro (SS-A) and La (SS-B) ribonucleoprotein complexes: structure, function and antigenicity.
Annales de médecine interne 1991;142(8):592-600.
1990: Ger J M Pruijn; R L Slobbe; Walther J van Venrooij
Structure and function of La and Ro RNPs.
Molecular biology reports 1990;14(2-3):43-8.
1990: R L Slobbe; Ger J M Pruijn; Walther J van Venrooij
Analysis of the molecular composition of Ro ribonucleoprotein particles.
Molecular biology reports 1990;14(2-3):55.