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Mark Ptashne

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TOP 3
Mark Ptashne
Epigenetics: Core misconcept.
Mark Ptashne
Faddish stuff: epigenetics and the inheritance of acquired characteristics.
Fella Hammachi; Keisuke Kaji; Minoru S H Ko; Alessandra Livigni; Gillian M Morrison; Santosh Narayan; James O'Malley; Eirini P Papapetrou; Mark Ptashne; Alexei A Sharov; Joshua M Brickman
Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency.

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All Publications

2013: Mark Ptashne
Epigenetics: Core misconcept.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(18):7101-3.
2013: Mark Ptashne
Faddish stuff: epigenetics and the inheritance of acquired characteristics.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(1):1-2.
2012: Fella Hammachi; Keisuke Kaji; Minoru S H Ko; Alessandra Livigni; Gillian M Morrison; Santosh Narayan; James O'Malley; Eirini P Papapetrou; Mark Ptashne; Alexei A Sharov; Joshua M Brickman
Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency.
Cell reports 2012;1(2):99-109.
2011: Xin Wang; Lu Bai; Gene O Bryant; Mark Ptashne
Nucleosomes and the accessibility problem.
Trends in genetics : TIG 2011;27(12):487-92.
2011: Mark Ptashne
Principles of a switch.
Nature chemical biology 2011;7(8):484-7.
2011: Xin Wang; Gene O Bryant; Monique Floer; Dan Spagna; Mark Ptashne
An effect of DNA sequence on nucleosome occupancy and removal.
Nature structural & molecular biology 2011;18(4):507-9.
2010: Xin Wang; Masafumi Muratani; William P Tansey; Mark Ptashne
Proteolytic instability and the action of nonclassical transcriptional activators.
Current biology : CB 2010;20(9):868-71.
2010: Monique Floer; Xin Wang; Vidya Prabhu; Georgina Berrozpe; Santosh Narayan; Dan Spagna; David Alvarez; Jude Kendall; Alexander Krasnitz; Asya Stepansky; James Hicks; Gene O Bryant; Mark Ptashne
A RSC/nucleosome complex determines chromatin architecture and facilitates activator binding.
Cell 2010;141(3):407-18.
2010: Mark Ptashne; Oliver Hobert; Eric Davidson
Questions over the scientific basis of epigenome project.
Nature 2010;464(7288):487.
2009: Mark Ptashne
Binding reactions: epigenetic switches, signal transduction and cancer.
Current biology : CB 2009;19(6):R234-41.
2008: Gene O Bryant; Vidya Prabhu; Monique Floer; Xin Wang; Dan Spagna; David Schreiber; Mark Ptashne
Activator control of nucleosome occupancy in activation and repression of transcription.
PLoS biology 2008;6(12):2928-39.
2008: Monique Floer; Gene O Bryant; Mark Ptashne
HSP90/70 chaperones are required for rapid nucleosome removal upon induction of the GAL genes of yeast.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2975-80.
2008: Mark Ptashne
Transcription: a mechanism for short-term memory.
Current biology : CB 2008;18(1):R25-7.
2007: Mark Ptashne
Repressors.
Current biology : CB 2007;17(17):R740-1.
2007: Mark Ptashne
Words.
Current biology : CB 2007;17(14):R533-5.
2007: Mark Ptashne
On learning to write.
Current biology : CB 2007;17(11):R394-5.
2007: Mark Ptashne
On speaking, writing and inspiration.
Current biology : CB 2007;17(10):R348-9.
2007: Mark Ptashne
On the use of the word 'epigenetic'.
Current biology : CB 2007;17(7):R233-6.
2006: Mark Ptashne
Lambda's switch: lessons from a module swap.
Current biology : CB 2006;16(12):R459-62.
2005: Mark Ptashne
Regulation of transcription: from lambda to eukaryotes.
Trends in biochemical sciences 2005;30(6):275-9.
2005: Sidney Altman; Bonnie L Bassler; Jon Beckwith; Marlene Belfort; Howard C Berg; Barry Bloom; Jean E Brenchley; Allan Campbell; R. John Collier; Nancy Connell; Nicholas R Cozzarelli; Nancy Craig; Seth Darst; Richard H. Ebright; Stephen J Elledge; Stanley Falkow; Jorge E Galan; Max Gottesman; Richard Gourse; Nigel D F Grindley; Carol A Gross; Alan Grossman; Ann Hochschild; Martha Howe; Jerard Hurwitz; Ralph R Isberg; Samuel Kaplan; Arthur Kornberg; Sydney G Kustu; Robert C Landick; Arthur Landy; Stuart B Levy; Richard Losick; Sharon R Long; Stanley R Maloy; John J Mekalanos; Frederick C Neidhardt; Norman R Pace; Mark Ptashne; Jeffrey W Roberts; John R Roth; Lucia B Rothman-Denes; Abigail A Salyers; Moselio Schaechter; Lucy Shapiro; Thomas J Silhavy; Melvin I Simon; Graham C Walker; Charles Yanofsky; Norton Zinder
An open letter to Elias Zerhouni.
Science (New York, N.Y.) 2005;307(5714):1409-10.
2005: Aseem Z Ansari; Anuja Ogirala; Mark Ptashne
Transcriptional activating regions target attached substrates to a cyclin-dependent kinase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2346-9.
2004: Jason Cheng; Michele Gandolfi; Mark Ptashne
Activation of the Gal1 gene of yeast by pairs of 'non-classical' activators.
Current biology : CB 2004;14(18):1675-9.
2004: Henri-Marc Bourbon; Andres Aguilera; Aseem Z Ansari; Francisco J Asturias; Arnold J Berk; Stefan Bjorklund; T Keith Blackwell; Tilman Borggrefe; Michael Carey; Marian Carlson; Joan W Conaway; Ronald C Conaway; Scott W Emmons; Joseph D Fondell; Leonard P Freedman; Toshio Fukasawa; Claes M Gustafsson; Min Han; Xi He; Paul K Herman; Alan G Hinnebusch; Steen Holmberg; Frank C Holstege; Judith A Jaehning; Young-Joon Kim; Laurent Kuras; Achim Leutz; John T Lis; Michael Meisterernest; Anders M Naar; Kim Nasmyth; Jeffrey D Parvin; Mark Ptashne; Danny Reinberg; Hans Ronne; Ivan Sadowski; Hiroshi Sakurai; Matthias Sipiczki; Paul W Sternberg; David J Stillman; Randy Strich; Kevin Struhl; Jasper Q Svejstrup; Simon Tuck; Fred Winston; Robert G Roeder; Roger D Kornberg
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
Molecular cell 2004;14(5):553-7.
2004: Mark Ptashne
Two "what if" experiments.
Cell 2004;116(2 Suppl):S71-2, 2 p following S76.
2003: Mark Ptashne
Regulated recruitment and cooperativity in the design of biological regulatory systems.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2003;361(1807):1223-34.
2003: Gene O Bryant; Mark Ptashne
Independent recruitment in vivo by Gal4 of two complexes required for transcription.
Molecular cell 2003;11(5):1301-9.
2003: Shamol Saha; Aseem Z Ansari; Kevin A Jarrell; Mark Ptashne; Kevin A Jarell
RNA sequences that work as transcriptional activating regions.
Nucleic acids research 2003;31(5):1565-70.
2003: Mark Ptashne; Alexander Gann
Signal transduction. Imposing specificity on kinases.
Science (New York, N.Y.) 2003;299(5609):1025-7.
2002: Aseem Z Ansari; Sang Seok Koh; Zafar Zaman; Christine Bongards; Norbert Lehming; Richard A Young; Mark Ptashne
Transcriptional activating regions target a cyclin-dependent kinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):14706-9.
2002: Paramjit S Arora; Aseem Z Ansari; Timothy P Best; Mark Ptashne; Peter B Dervan
Design of artificial transcriptional activators with rigid poly-L-proline linkers.
Journal of the American Chemical Society 2002;124(44):13067-71.
2002: Jason Cheng; Monique Floer; Paul Ononaji; Gene Bryant; Mark Ptashne
Responses of four yeast genes to changes in the transcriptional machinery are determined by their promoters.
Current biology : CB 2002;12(21):1828-32.
2002: Zhen Lu; Aseem Z Ansari; Xiangyang Lu; Anuja Ogirala; Mark Ptashne
A target essential for the activity of a nonacidic yeast transcriptional activator.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8591-6.
2002: Jason Cheng; Julian Nevado; Zhen Lu; Mark Ptashne
The TBP-inhibitory domain of TAF145 limits the effects of nonclassical transcriptional activators.
Current biology : CB 2002;12(11):934-7.
2002: Zafar Zaman; Christopher Heid; Mark Ptashne
Telomere looping permits repression "at a distance" in yeast.
Current biology : CB 2002;12(11):930-3.
2001: Aseem Z Ansari; Anna K Mapp; D H Nguyen; Peter B Dervan; Mark Ptashne
Towards a minimal motif for artificial transcriptional activators.
Chemistry & biology 2001;8(6):583-92.
2001: P Hidalgo; Aseem Z Ansari; P Schmidt; BJ Hare; N Simkovich; S Farrell; E J Shin; Mark Ptashne; Gerhard Wagner
Recruitment of the transcriptional machinery through GAL11P: structure and interactions of the GAL4 dimerization domain.
Genes & development 2001;15(8):1007-20.
2001: Zafar Zaman; Aseem Z Ansari; Sang Seok Koh; R Young; Mark Ptashne
Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2550-4.
2001: D de Bruin; Zafar Zaman; R A Liberatore; Mark Ptashne
Telomere looping permits gene activation by a downstream UAS in yeast.
Nature 2001;409(6816):109-13.
2001: Mark Ptashne; Alexander Gann
Transcription initiation: imposing specificity by localization.
Essays in biochemistry 2001;37():1-15.
2000: Anna K Mapp; Aseem Z Ansari; Mark Ptashne; Peter B Dervan
Activation of gene expression by small molecule transcription factors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3930-5.
2000: E Torigoi; idriss bennani-baiti; C Rosen; K Gonzalez; Patrick Morcillo; Mark Ptashne; Dale Dorsett
Chip interacts with diverse homeodomain proteins and potentiates bicoid activity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2686-91.
2000: X Lu; Aseem Z Ansari; Mark Ptashne
An artificial transcriptional activating region with unusual properties.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):1988-92.
1999: J M Brickman; M Adam; Mark Ptashne
Interactions between an HMG-1 protein and members of the Rel family.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10679-83.
1999: Julian Nevado; L Gaudreau; M Adam; Mark Ptashne
Transcriptional activation by artificial recruitment in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2674-7.
1999: L Gaudreau; M Keaveney; Julian Nevado; Zafar Zaman; G O Bryant; Kevin Struhl; Mark Ptashne
Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2668-73.
1998: Aseem Z Ansari; R J Reece; Mark Ptashne
A transcriptional activating region with two contrasting modes of protein interaction.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13543-8.
1998: Mark Ptashne; Alexander Gann
Imposing specificity by localization: mechanism and evolvability.
Current biology : CB 1998;8(22):R812-22.
1998: Norbert Lehming; Agnès Le Saux; Jutta Schüller; Mark Ptashne
Chromatin components as part of a putative transcriptional repressing complex.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7322-6.
1998: L Gaudreau; M Adam; Mark Ptashne
Activation of transcription in vitro by recruitment of the yeast RNA polymerase II holoenzyme.
Molecular cell 1998;1(6):913-6.
1998: Sang Seok Koh; Aseem Z Ansari; Mark Ptashne; Richard A Young
An activator target in the RNA polymerase II holoenzyme.
Molecular cell 1998;1(6):895-904.
1998: Zafar Zaman; Aseem Z Ansari; L Gaudreau; Julian Nevado; Mark Ptashne
Gene transcription by recruitment.
Cold Spring Harbor symposia on quantitative biology 1998;63():167-71.
1997: Mark Ptashne
1997 Albert Lasker Award for Basic Medical Research. Control of gene transcription: an outline.
Nature medicine 1997;3(10):1069-72.
1997: Kylie J Walters; Theodore Kwaku Dayie; R J Reece; Mark Ptashne; Gerhard Wagner
Structure and mobility of the PUT3 dimer.
Nature structural biology 1997;4(9):744-50.
1997: Mark Ptashne; Alexander Gann
Transcriptional activation by recruitment.
Nature 1997;386(6625):569-77.
1997: L Gaudreau; A Schmid; Dorothea Blaschke; Mark Ptashne; Wolfram Hörz
RNA polymerase II holoenzyme recruitment is sufficient to remodel chromatin at the yeast PHO5 promoter.
Cell 1997;89(1):55-62.
1997: FW Whipple; Mark Ptashne; Ann Hochschild
The activation defect of a lambda cI positive control mutant.
Journal of molecular biology 1997;265(3):261-5.
1996: S Farrell; N Simkovich; Y Wu; Alcide Barberis; Mark Ptashne
Gene activation by recruitment of the RNA polymerase II holoenzyme.
Genes & development 1996;10(18):2359-67.
1996: Y Wu; R J Reece; Mark Ptashne
Quantitation of putative activator-target affinities predicts transcriptional activating potentials.
The EMBO journal 1996;15(15):3951-63.
1996: S D Liang; R Marmorstein; S C Harrison; Mark Ptashne
DNA sequence preferences of GAL4 and PPR1: how a subset of Zn2 Cys6 binuclear cluster proteins recognizes DNA.
Molecular and cellular biology 1996;16(7):3773-80.
1995: N Lehming; S McGuire; J M Brickman; Mark Ptashne
Interactions of a Rel protein with its inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10242-6.
1995: A Astromoff; Mark Ptashne
A variant of lambda repressor with an altered pattern of cooperative binding to DNA sites.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8110-4.
1995: Alcide Barberis; J Pearlberg; N Simkovich; S Farrell; P Reinagel; C Bamdad; G Sigal; Mark Ptashne
Contact with a component of the polymerase II holoenzyme suffices for gene activation.
Cell 1995;81(3):359-68.
1994: N Lehming; D Thanos; J M Brickman; Jianfei Ma; T Maniatis; Mark Ptashne
An HMG-like protein that can switch a transcriptional activator to a repressor.
Nature 1994;371(6493):175-9.
1993: R J Reece; Mark Ptashne
Determinants of binding-site specificity among yeast C6 zinc cluster proteins.
Science (New York, N.Y.) 1993;261(5123):909-11.
1993: S Saha; J M Brickman; N Lehming; Mark Ptashne
New eukaryotic transcriptional repressors.
Nature 1993;363(6430):648-52.
1993: Alcide Barberis; C W Müller; S C Harrison; Mark Ptashne
Delineation of two functional regions of transcription factor TFIIB.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5628-32.
1993: R Baumann; E Grogan; Mark Ptashne; I G Miller
Changing Epstein-Barr viral ZEBRA protein into a more powerful activator enhances its capacity to disrupt latency.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4436-40.
1993: R J Reece; R J Rickles; Mark Ptashne
Overproduction and single-step purification of GAL4 fusion proteins from Escherichia coli.
Gene 1993;126(1):105-7.
1992: M S Lamphier; Mark Ptashne
Multiple mechanisms mediate glucose repression of the yeast GAL1 gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):5922-6.
1992: R Marmorstein; M Carey; Mark Ptashne; S C Harrison
DNA recognition by GAL4: structure of a protein-DNA complex.
Nature 1992;356(6368):408-14.
1992: L Guarante; Thomas M Roberts; Mark Ptashne
A technique for expressing eukaryotic genes in bacteria. 1980.
Biotechnology (Reading, Mass.) 1992;24():261-3.
1991: Ivan Sadowski; D Niedbala; K Wood; Mark Ptashne
GAL4 is phosphorylated as a consequence of transcriptional activation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10510-4.
1991: Mark Ptashne
Alfred P. Sloan, Jr. Prize. Gene regulation.
Cancer 1991;67(10):2422-7.
1991: Douglas M Ruden; Jianfei Ma; Y Li; K Wood; Mark Ptashne
Generating yeast transcriptional activators containing no yeast protein sequences.
Nature 1991;350(6315):250-2.
1990: H J Himmelfarb; J Pearlberg; D H Last; Mark Ptashne
GAL11P: a yeast mutation that potentiates the effect of weak GAL4-derived activators.
Cell 1990;63(6):1299-309.
1990: Mark Ptashne; A A Gann
Activators and targets.
Nature 1990;346(6282):329-31.
1990: Y S Lin; M Carey; Mark Ptashne; M R Green
How different eukaryotic transcriptional activators can cooperate promiscuously.
Nature 1990;345(6273):359-61.
1990: M Carey; Y S Lin; M R Green; Mark Ptashne
A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives.
Nature 1990;345(6273):361-4.
1990: G Gill; Ivan Sadowski; Mark Ptashne
Mutations that increase the activity of a transcriptional activator in yeast and mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2127-31.
1990: M Carey; J Leatherwood; Mark Ptashne
A potent GAL4 derivative activates transcription at a distance in vitro.
Science (New York, N.Y.) 1990;247(4943):710-2.
1989: D Valenzuela; Mark Ptashne
P22 repressor mutants deficient in co-operative binding and DNA loop formation.
The EMBO journal 1989;8(13):4345-50.
1989: W Driever; J Ma; Christiane Nüsslein-Volhard; Mark Ptashne
Rescue of bicoid mutant Drosophila embryos by bicoid fusion proteins containing heterologous activating sequences.
Nature 1989;342(6246):149-54.
1989: D I Chasman; J Leatherwood; M Carey; Mark Ptashne; Roger D Kornberg
Activation of yeast polymerase II transcription by herpesvirus VP16 and GAL4 derivatives in vitro.
Molecular and cellular biology 1989;9(11):4746-9.
1989: M Carey; H Kakidani; J Leatherwood; F Mostashari; Mark Ptashne
An amino-terminal fragment of GAL4 binds DNA as a dimer.
Journal of molecular biology 1989;209(3):423-32.
1989: Ivan Sadowski; Mark Ptashne
A vector for expressing GAL4(1-147) fusions in mammalian cells.
Nucleic acids research 1989;17(18):7539.
1989: F D Bushman; Charles Shang; Mark Ptashne
A single glutamic acid residue plays a key role in the transcriptional activation function of lambda repressor.
Cell 1989;58(6):1163-71.
1989: Mark Ptashne
How gene activators work.
Scientific American 1989;260(1):40-7.
1988: A Hochschild; Mark Ptashne
Interaction at a distance between lambda repressors disrupts gene activation.
Nature 1988;336(6197):353-7.
1988: A K Aggarwal; D W Rodgers; M Drottar; Mark Ptashne; S C Harrison
Recognition of a DNA operator by the repressor of phage 434: a view at high resolution.
Science (New York, N.Y.) 1988;242(4880):899-907.
1988: Jianfei Ma; Mark Ptashne
Converting a eukaryotic transcriptional inhibitor into an activator.
Cell 1988;55(3):443-6.
1988: Cynthia Wolberger; Y C Dong; Mark Ptashne; S C Harrison
Structure of a phage 434 Cro/DNA complex.
Nature 1988;335(6193):789-95.
1988: Mark Ptashne
How eukaryotic transcriptional activators work.
Nature 1988;335(6192):683-9.
1988: Ivan Sadowski; Jianfei Ma; Steven J Triezenberg; Mark Ptashne
GAL4-VP16 is an unusually potent transcriptional activator.
Nature 1988;335(6190):563-4.
1988: Y S Lin; M F Carey; Mark Ptashne; M R Green
GAL4 derivatives function alone and synergistically with mammalian activators in vitro.
Cell 1988;54(5):659-64.
1988: G Gill; Mark Ptashne
Negative effect of the transcriptional activator GAL4.
Nature 1988;334(6184):721-4.
1988: Jianfei Ma; E Przibilla; J Hu; lawrence Bogorad; Mark Ptashne
Yeast activators stimulate plant gene expression.
Nature 1988;334(6183):631-3.
1988: M Hollis; D Valenzuela; D Pioli; R Wharton; Mark Ptashne
A repressor heterodimer binds to a chimeric operator.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5834-8.
1988: F D Bushman; Mark Ptashne
Turning lambda Cro into a transcriptional activator.
Cell 1988;54(2):191-7.
1988: G B Koudelka; P Harbury; S C Harrison; Mark Ptashne
DNA twisting and the affinity of bacteriophage 434 operator for bacteriophage 434 repressor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4633-7.
1988: Douglas M Ruden; Jianfei Ma; Mark Ptashne
No strict alignment is required between a transcriptional activator binding site and the "TATA box" of a yeast gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4262-6.
1988: J A Fischer; E Giniger; T Maniatis; Mark Ptashne
GAL4 activates transcription in Drosophila.
Nature 1988;332(6167):853-6.
1988: S C Harrison; J E Anderson; G B Koudelka; A Mondragon; S Subbiah; R P Wharton; Cynthia Wolberger; Mark Ptashne
Recognition of DNA sequences by the repressor of bacteriophage 434.
Biophysical chemistry 1988;29(1-2):31-7.
1988: H Kakidani; Mark Ptashne
GAL4 activates gene expression in mammalian cells.
Cell 1988;52(2):161-7.
1988: E Giniger; Mark Ptashne
Cooperative DNA binding of the yeast transcriptional activator GAL4.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):382-6.
1987: E Giniger; Mark Ptashne
Transcription in yeast activated by a putative amphipathic alpha helix linked to a DNA binding unit.
Nature 1987;330(6149):670-2.
1987: N Irwin; Mark Ptashne
Mutants of the catabolite activator protein of Escherichia coli that are specifically deficient in the gene-activation function.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8315-9.
1987: G Gill; Mark Ptashne
Mutants of GAL4 protein altered in an activation function.
Cell 1987;51(1):121-6.
1987: Jianfei Ma; Mark Ptashne
A new class of yeast transcriptional activators.
Cell 1987;51(1):113-9.
1987: J Ma; Mark Ptashne
The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80.
Cell 1987;50(1):137-42.
1987: R P Wharton; Mark Ptashne
A new-specificity mutant of 434 repressor that defines an amino acid-base pair contact.
Nature 1987;326(6116):888-91.
1987: G B Koudelka; S C Harrison; Mark Ptashne
Effect of non-contacted bases on the affinity of 434 operator for 434 repressor and Cro.
Nature 1987;326(6116):886-8.
1987: J E Anderson; Mark Ptashne; S C Harrison
Structure of the repressor-operator complex of bacteriophage 434.
Nature 1987;326(6116):846-52.
1987: J Ma; Mark Ptashne
Deletion analysis of GAL4 defines two transcriptional activating segments.
Cell 1987;48(5):847-53.
1986: A Hochschild; J Douhan; Mark Ptashne
How lambda repressor and lambda Cro distinguish between OR1 and OR3.
Cell 1986;47(5):807-16.
1986: F D Bushman; Mark Ptashne
Activation of transcription by the bacteriophage 434 repressor.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9353-7.
1986: P A Silver; R Brent; Mark Ptashne
DNA binding is not sufficient for nuclear localization of regulatory proteins in Saccharomyces cerevisiae.
Molecular and cellular biology 1986;6(12):4763-6.
1986: Jack D Griffith; A Hochschild; Mark Ptashne
DNA loops induced by cooperative binding of lambda repressor.
Nature 1986;322(6081):750-2.
1986: Mark Ptashne
Gene regulation by proteins acting nearby and at a distance.
Nature 1986;322(6081):697-701.
1986: Jacqueline Sharon; M L Gefter; Tim Manser; Mark Ptashne
Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibody.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2628-31.
1986: A Hochschild; Mark Ptashne
Homologous interactions of lambda repressor and lambda Cro with the lambda operator.
Cell 1986;44(6):925-33.
1986: A Hochschild; Mark Ptashne
Cooperative binding of lambda repressors to sites separated by integral turns of the DNA helix.
Cell 1986;44(5):681-7.
1986: L Keegan; G Gill; Mark Ptashne
Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein.
Science (New York, N.Y.) 1986;231(4739):699-704.
1985: R Brent; Mark Ptashne
A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor.
Cell 1985;43(3 Pt 2):729-36.
1985: F D Bushman; J E Anderson; S C Harrison; Mark Ptashne
Ethylation interference and X-ray crystallography identify similar interactions between 434 repressor and operator.
Nature 1985;316(6029):651-3.
1985: R P Wharton; Mark Ptashne
Changing the binding specificity of a repressor by redesigning an alpha-helix.
Nature 1985;316(6029):601-5.
1985: J E Anderson; Mark Ptashne; S C Harrison
A phage repressor-operator complex at 7 A resolution.
Nature 1985;316(6029):596-601.
1985: E Giniger; S M Varnum; Mark Ptashne
Specific DNA binding of GAL4, a positive regulatory protein of yeast.
Cell 1985;40(4):767-74.
1985: J L Eliason; M A Weiss; Mark Ptashne
NH2-terminal arm of phage lambda repressor contributes energy and specificity to repressor binding and determines the effects of operator mutations.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(8):2339-43.
1985: R Brent; Mark Ptashne
A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene.
Nature 1985;314(6007):198.
1984: R Brent; Mark Ptashne
A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene.
Nature 1984;312(5995):612-5.
1984: R W West; R R Yocum; Mark Ptashne
Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASG.
Molecular and cellular biology 1984;4(11):2467-78.
1984: R R Yocum; S Hanley; R West; Mark Ptashne
Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.
Molecular and cellular biology 1984;4(10):1985-98.
1984: D Kimelman; L A Lucher; K H Brackmann; J S Symington; Mark Ptashne; M Green
Synthesis in Escherichia coli of human adenovirus type 12 transforming proteins encoded by early region 1A 13S mRNA and 12S mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(20):6300-4.
1984: P A Silver; L P Keegan; Mark Ptashne
Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(19):5951-5.
1984: R P Wharton; E L Brown; Mark Ptashne
Substituting an alpha-helix switches the sequence-specific DNA interactions of a repressor.
Cell 1984;38(2):361-9.
1984: Jacqueline Sharon; M L Gefter; Tim Manser; S L Morrison; V T Oi; Mark Ptashne
Expression of a VHC kappa chimaeric protein in mouse myeloma cells.
Nature 1984;309(5966):364-7.
1984: Mark Ptashne
DNA-binding proteins.
Nature 1984;308(5961):753-4.
1984: J Anderson; Mark Ptashne; S C Harrison
Cocrystals of the DNA-binding domain of phage 434 repressor and a synthetic phage 434 operator.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(5):1307-11.
1983: E Amann; J Brosius; Mark Ptashne
Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli.
Gene 1983;25(2-3):167-78.
1983: A Hochschild; N Irwin; Mark Ptashne
Repressor structure and the mechanism of positive control.
Cell 1983;32(2):319-25.
1983: M Lewis; A Jeffrey; J Wang; R Ladner; Mark Ptashne; C O Pabo
Structure of the operator-binding domain of bacteriophage lambda repressor: implications for DNA recognition and gene regulation.
Cold Spring Harbor symposia on quantitative biology 1983;47 Pt 1():435-40.
1982: Mark Ptashne; A D Johnson; C O Pabo
A genetic switch in a bacterial virus.
Scientific American 1982;247(5):128-30, 132, 134-40.
1982: Cynthia Kenyon; R Brent; Mark Ptashne; Graham C Walker
Regulation of damage-inducible genes in Escherichia coli.
Journal of molecular biology 1982;160(3):445-57.
1982: K Zinn; P Mellon; Mark Ptashne; T Maniatis
Regulated expression of an extrachromosomal human beta-interferon gene in mouse cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(16):4897-901.
1982: A R Poteete; Mark Ptashne
Control of transcription by the bacteriophage P22 repressor.
Journal of molecular biology 1982;157(1):21-48.
1982: R T Sauer; M J Ross; Mark Ptashne
Cleavage of the lambda and P22 repressors by recA protein.
The Journal of biological chemistry 1982;257(8):4458-62.
1982: L Guarente; J S Nye; A Hochschild; Mark Ptashne
Mutant lambda phage repressor with a specific defect in its positive control function.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(7):2236-9.
1981: A D Johnson; A R Poteete; G Lauer; R T Sauer; G K Ackers; Mark Ptashne
lambda Repressor and cro--components of an efficient molecular switch.
Nature 1981;294(5838):217-23.
1981: R Brent; Mark Ptashne
Mechanism of action of the lexA gene product.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4204-8.
1981: L Guarente; Mark Ptashne
Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(4):2199-203.
1981: G Lauer; R Pastrana; J Sherley; Mark Ptashne
Construction of overproducers of the bacteriophage 434 repressor and cro proteins.
Journal of molecular and applied genetics 1981;1(2):139-47.
1980: L Guarente; Thomas M Roberts; Mark Ptashne
A technique for expressing eukaryotic genes in bacteria.
Science (New York, N.Y.) 1980;209(4463):1428-30.
1980: T Taniguchi; L Guarente; Thomas M Roberts; D Kimelman; J Douhan; Mark Ptashne
Expression of the human fibroblast interferon gene in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(9):5230-3.
1980: L Guarente; G Lauer; Thomas M Roberts; Mark Ptashne
Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit beta-globin.
Cell 1980;20(2):543-53.
1980: B J Meyer; Mark Ptashne
Gene regulation at the right operator (OR) of bacteriophage lambda. III. lambda repressor directly activates gene transcription.
Journal of molecular biology 1980;139(2):195-205.
1980: B J Meyer; R Maurer; Mark Ptashne
Gene regulation at the right operator (OR) of bacteriophage lambda. II. OR1, OR2, and OR3: their roles in mediating the effects of repressor and cro.
Journal of molecular biology 1980;139(2):163-94.
1980: R Maurer; B Meyer; Mark Ptashne
Gene regulation at the right operator (OR) bacteriophage lambda. I. OR3 and autogenous negative control by repressor.
Journal of molecular biology 1980;139(2):147-61.
1980: R Brent; Mark Ptashne
The lexA gene product represses its own promoter.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(4):1932-6.
1980: A R Poteete; Mark Ptashne; M Ballivet; H Eisen
Operator sequences of bacteriophages P22 and 21.
Journal of molecular biology 1980;137(1):81-91.
1980: Mark Ptashne; A Jeffrey; A D Johnson; R Maurer; B J Meyer; C O Pabo; Thomas M Roberts; R T Sauer
How the lambda repressor and cro work.
Cell 1980;19(1):1-11.
1979: T M Roberts; I Bikel; R R Yocum; D M Livingston; Mark Ptashne
Synthesis of simian virus 40 t antigen in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(11):5596-600.
1979: A D Johnson; B J Meyer; Mark Ptashne
Interactions between DNA-bound repressors govern regulation by the lambda phage repressor.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(10):5061-5.
1979: R T Sauer; C O Pabo; B J Meyer; Mark Ptashne; K C Backman
Regulatory functions of the lambda repressor reside in the amino-terminal domain.
Nature 1979;279(5712):396-400.
1979: C O Pabo; R T Sauer; Julian M Sturtevant; Mark Ptashne
The lambda repressor contains two domains.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(4):1608-12.
1979: T M Roberts; R Kacich; Mark Ptashne
A general method for maximizing the expression of a cloned gene.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(2):760-4.
1978: A Johnson; B J Meyer; Mark Ptashne
Mechanism of action of the cro protein of bacteriophage lambda.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(4):1783-7.
1978: K Backman; Mark Ptashne
Maximizing gene expression on a plasmid using recombination in vitro.
Cell 1978;13(1):65-71.
1977: Z Humayun; A Jeffrey; Mark Ptashne
Completed DNA sequences and organization of repressor-binding sites in the operators of phage lambda.
Journal of molecular biology 1977;112(2):265-77.
1977: Z Humayun; D Kleid; Mark Ptashne
Sites of contact between lambda operators and lambda repressor.
Nucleic acids research 1977;4(5):1595-607.
1976: K Backman; Mark Ptashne; Walter Gilbert
Construction of plasmids carrying the cI gene of bacteriophage lambda.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(11):4174-8.
1976: Mark Ptashne; K Backman; M Z Humayun; A Jeffrey; R Maurer; B Meyer; R T Sauer
Autoregulation and function of a repressor in bacteriophage lambda.
Science (New York, N.Y.) 1976;194(4261):156-61.
1976: D Kleid; Z Humayun; A Jeffrey; Mark Ptashne
Novel properties of a restriction endonuclease isolated from Haemophilus parahaemolyticus.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(2):293-7.
1976: T Maniatis; Mark Ptashne
A DNA operator-repressor system.
Scientific American 1976;234(1):64-6, 71-6.
1975: B J Meyer; D G Kleid; Mark Ptashne
Lambda repressor turns off transcription of its own gene.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(12):4785-89.
1975: T Maniatis; Mark Ptashne; K Backman; D Kield; S Flashman; A Jeffrey; R Maurer
Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda.
Cell 1975;5(2):109-13.
1974: T Maniatis; Mark Ptashne; B G Barrell; J Donelson
Sequence of a repressor-binding site in the DNA of bacteriophage lamda.
Nature 1974;250(465):394-7.
1974: R Maurer; T Maniatis; Mark Ptashne
Promoters are in the operators in phage lambda.
Nature 1974;249(454):221-3.
1974: T Maniatis; Mark Ptashne; R Maurer
Control elements in the DNA of bacteriophage lambda.
Cold Spring Harbor symposia on quantitative biology 1974;38():857-68.
1973: T Maniatis; Mark Ptashne
Structure of the lambda operators.
Nature 1973;246(5429):133-6.
1973: T Maniatis; Mark Ptashne
Multiple repressor binding at the operators in bacteriophage lambda.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(5):1531-5.
1973: Mark Ptashne
Repressor, operators, and promoters in bacteriophage lambda.
Harvey lectures 1973;(69):143-71.
1971: R A Steinberg; Mark Ptashne
In vitro repression of RNA synthesis by purified lambda phage repressor.
Nature: New biology 1971;230(11):76-80.
1971: Mark Ptashne
Phage repressors. In: strategy of the viral genome.
Ciba Foundation symposium 1971;():155-68.
1970: V Pirrotta; P Chadwick; Mark Ptashne
Active form of two coliphage repressors.
Nature 1970;227(5253):41-4.
1970: Mark Ptashne; Walter Gilbert
Genetic repressors.
Scientific American 1970;222(6):36-44.
1969: V Pirrotta; Mark Ptashne
Isolation of the 434 phage repressor.
Nature 1969;222(5193):541-4.
1968: Mark Ptashne; N Hopkins
The operators controlled by the lambda phage repressor.
Proceedings of the National Academy of Sciences of the United States of America 1968;60(4):1282-7.
1967: Mark Ptashne
Specific binding of the lambda phage repressor to lambda DNA.
Nature 1967;214(5085):232-4.
1965: Mark Ptashne
REPLICATION AND HOST MODIFICATION OF DNA TRANSFERRED DURING BACTERIAL MATING.
Journal of molecular biology 1965;11():829-38.
1965: Mark Ptashne
THE DETACHMENT AND MATURATION OF CONSERVED LAMBDA PROPHAGE DNA.
Journal of molecular biology 1965;11():90-6.
1960: Mark Ptashne
The Behavior of Strong and Weak Centromeres at Second Anaphase of Drosophila Melanogaster.
Genetics 1960;45(4):499-506.