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Mark Ptashne

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Physiology

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Protein Binding

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Co-Publications
Name
13
Ansari, Aseem
7
Ma, Jianfei
6
Zaman, Zafar
5
Roberts, Thomas
5
Gaudreau, L
4
Sadowski, Ivan
4
Nevado, Julian
4
Gann, Alexander
3
Cheng, Jason
3
Koh, Sang Seok
3
Dervan, Peter
3
Barberis, Alcide
3
Floer, Monique
2
Wagner, Gerhard
2
Ruden, Douglas

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Publications

TOP 3
Ptashne Mark
Binding reactions: epigenetic switches, signal transduction and cancer.
Bryant Gene O; Prabhu Vidya; Floer Monique; Wang Xin; Spagna Dan; Schreiber David; Ptashne Mark
Activator control of nucleosome occupancy in activation and repression of transcription.
Floer Monique; Bryant Gene O; Ptashne Mark
HSP90/70 chaperones are required for rapid nucleosome removal upon induction of the GAL genes of yeast.

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All Publications

2009: Ptashne Mark
Binding reactions: epigenetic switches, signal transduction and cancer.
Current biology : CB 2009;19(6):R234-41.
2008: Bryant Gene O; Prabhu Vidya; Floer Monique; Wang Xin; Spagna Dan; Schreiber David; Ptashne Mark
Activator control of nucleosome occupancy in activation and repression of transcription.
PLoS biology 2008;6(12):2928-39.
2008: Floer Monique; Bryant Gene O; Ptashne Mark
HSP90/70 chaperones are required for rapid nucleosome removal upon induction of the GAL genes of yeast.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2975-80.
2008: Ptashne Mark
Transcription: a mechanism for short-term memory.
Current biology : CB 2008;18(1):R25-7.
2007: Ptashne Mark
Repressors.
Current biology : CB 2007;17(17):R740-1.
2007: Ptashne Mark
Words.
Current biology : CB 2007;17(14):R533-5.
2007: Ptashne Mark
On learning to write.
Current biology : CB 2007;17(11):R394-5.
2007: Ptashne Mark
On speaking, writing and inspiration.
Current biology : CB 2007;17(10):R348-9.
2007: Ptashne Mark
On the use of the word 'epigenetic'.
Current biology : CB 2007;17(7):R233-6.
2006: Ptashne Mark
Lambda's switch: lessons from a module swap.
Current biology : CB 2006;16(12):R459-62.
2005: Ptashne Mark
Regulation of transcription: from lambda to eukaryotes.
Trends in biochemical sciences 2005;30(6):275-9.
2005: Altman Sidney; Bassler Bonnie L; Beckwith Jon; Belfort Marlene; Berg Howard C; Bloom Barry; Brenchley Jean E; Campbell Allan; Collier R John; Connell Nancy; Cozzarelli Nicholas R; Craig Nancy L; Darst Seth; Ebright Richard H; Elledge Stephen J; Falkow Stanley; Galan Jorge E; Gottesman Max; Gourse Richard; Grindley Nigel D F; Gross Carol A; Grossman Alan; Hochschild Ann; Howe Martha; Hurwitz Jerard; Isberg Ralph R; Kaplan Samuel; Kornberg Arthur; Kustu Sydney G; Landick Robert C; Landy Arthur; Levy Stuart B; Losick Richard; Long Sharon R; Maloy Stanley R; Mekalanos John J; Neidhardt Frederick C; Pace Norman R; Ptashne Mark; Roberts Jeffrey W; Roth John R; Rothman-Denes Lucia B; Salyers Abigail; Schaechter Moselio; Shapiro Lucy; Silhavy Thomas J; Simon Melvin I; Walker Graham; Yanofsky Charles; Zinder Norton
An open letter to Elias Zerhouni.
Science (New York, N.Y.) 2005;307(5714):1409-10.
2005: Ansari Aseem Z; Ogirala Anuja; Ptashne Mark
Transcriptional activating regions target attached substrates to a cyclin-dependent kinase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2346-9.
2004: Cheng Jason X; Gandolfi Michele; Ptashne Mark
Activation of the Gal1 gene of yeast by pairs of 'non-classical' activators.
Current biology : CB 2004;14(18):1675-9.
2004: Bourbon Henri-Marc; Aguilera Andres; Ansari Aseem Z; Asturias Francisco J; Berk Arnold J; Bjorklund Stefan; Blackwell T Keith; Borggrefe Tilman; Carey Michael; Carlson Marian; Conaway Joan W; Conaway Ronald C; Emmons Scott W; Fondell Joseph D; Freedman Leonard P; Fukasawa Toshio; Gustafsson Claes M; Han Min; He Xi; Herman Paul K; Hinnebusch Alan G; Holmberg Steen; Holstege Frank C; Jaehning Judith A; Kim Young-Joon; Kuras Laurent; Leutz Achim; Lis John T; Meisterernest Michael; Naar Anders M; Nasmyth Kim; Parvin Jeffrey D; Ptashne Mark; Reinberg Danny; Ronne Hans; Sadowski Ivan; Sakurai Hiroshi; Sipiczki Matthias; Sternberg Paul W; Stillman David J; Strich Randy; Struhl Kevin; Svejstrup Jasper Q; Tuck Simon; Winston Fred; Roeder Robert G; Kornberg Roger D
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
Molecular cell 2004;14(5):553-7.
2004: Ptashne Mark
Two "what if" experiments.
Cell 2004;116(2 Suppl):S71-2, 2 p following S76.
2003: Ptashne Mark
Regulated recruitment and cooperativity in the design of biological regulatory systems.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2003;361(1807):1223-34.
2003: Bryant Gene O; Ptashne Mark
Independent recruitment in vivo by Gal4 of two complexes required for transcription.
Molecular cell 2003;11(5):1301-9.
2003: Saha Shamol; Ansari Aseem Z; Jarrell Kevin A; Ptashne Mark;
RNA sequences that work as transcriptional activating regions.
Nucleic acids research 2003;31(5):1565-70.
2003: Ptashne Mark; Gann Alexander
Signal transduction. Imposing specificity on kinases.
Science (New York, N.Y.) 2003;299(5609):1025-7.
2002: Ansari Aseem Z; Koh Sang Seok; Zaman Zafar; Bongards Christine; Lehming Norbert; Young Richard A; Ptashne Mark
Transcriptional activating regions target a cyclin-dependent kinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):14706-9.
2002: Arora Paramjit S; Ansari Aseem Z; Best Timothy P; Ptashne Mark; Dervan Peter B
Design of artificial transcriptional activators with rigid poly-L-proline linkers.
Journal of the American Chemical Society 2002;124(44):13067-71.
2002: Cheng Jason X; Floer Monique; Ononaji Paul; Bryant Gene; Ptashne Mark
Responses of four yeast genes to changes in the transcriptional machinery are determined by their promoters.
Current biology : CB 2002;12(21):1828-32.
2002: Lu Zhen; Ansari Aseem Z; Lu Xiangyang; Ogirala Anuja; Ptashne Mark
A target essential for the activity of a nonacidic yeast transcriptional activator.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8591-6.
2002: Cheng Jason X; Nevado Julian; Lu Zhen; Ptashne Mark
The TBP-inhibitory domain of TAF145 limits the effects of nonclassical transcriptional activators.
Current biology : CB 2002;12(11):934-7.
2002: Zaman Zafar; Heid Christopher; Ptashne Mark
Telomere looping permits repression "at a distance" in yeast.
Current biology : CB 2002;12(11):930-3.
2001: Ansari A Z; Mapp A K; Nguyen D H; Dervan P B; Ptashne M
Towards a minimal motif for artificial transcriptional activators.
Chemistry & biology 2001;8(6):583-92.
2001: Hidalgo P; Ansari A Z; Schmidt P; Hare B; Simkovich N; Farrell S; Shin E J; Ptashne M; Wagner G
Recruitment of the transcriptional machinery through GAL11P: structure and interactions of the GAL4 dimerization domain.
Genes & development 2001;15(8):1007-20.
2001: Zaman Z; Ansari A Z; Koh S S; Young R; Ptashne M
Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2550-4.
2001: de Bruin D; Zaman Z; Liberatore R A; Ptashne M
Telomere looping permits gene activation by a downstream UAS in yeast.
Nature 2001;409(6816):109-13.
2001: Ptashne M; Gann A
Transcription initiation: imposing specificity by localization.
Essays in biochemistry 2001;37():1-15.
2000: Mapp A K; Ansari A Z; Ptashne M; Dervan P B
Activation of gene expression by small molecule transcription factors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3930-5.
2000: Torigoi E; Bennani-Baiti I M; Rosen C; Gonzalez K; Morcillo P; Ptashne M; Dorsett D
Chip interacts with diverse homeodomain proteins and potentiates bicoid activity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2686-91.
2000: Lu X; Ansari A Z; Ptashne M
An artificial transcriptional activating region with unusual properties.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):1988-92.
1999: Brickman J M; Adam M; Ptashne M
Interactions between an HMG-1 protein and members of the Rel family.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10679-83.
1999: Nevado J; Gaudreau L; Adam M; Ptashne M
Transcriptional activation by artificial recruitment in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2674-7.
1999: Gaudreau L; Keaveney M; Nevado J; Zaman Z; Bryant G O; Struhl K; Ptashne M
Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2668-73.
1998: Ptashne M; Gann A
Imposing specificity by localization: mechanism and evolvability.
Current biology : CB 1998;8(22):R812-22.
1998: Ansari A Z; Reece R J; Ptashne M
A transcriptional activating region with two contrasting modes of protein interaction.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13543-8.
1998: Lehming N; Le Saux A; Schüller J; Ptashne M
Chromatin components as part of a putative transcriptional repressing complex.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7322-6.
1998: Gaudreau L; Adam M; Ptashne M
Activation of transcription in vitro by recruitment of the yeast RNA polymerase II holoenzyme.
Molecular cell 1998;1(6):913-6.
1998: Koh S S; Ansari A Z; Ptashne M; Young R A
An activator target in the RNA polymerase II holoenzyme.
Molecular cell 1998;1(6):895-904.
1998: Zaman Z; Ansari A Z; Gaudreau L; Nevado J; Ptashne M
Gene transcription by recruitment.
Cold Spring Harbor symposia on quantitative biology 1998;63():167-71.
1997: Ptashne M
1997 Albert Lasker Award for Basic Medical Research. Control of gene transcription: an outline.
Nature medicine 1997;3(10):1069-72.
1997: Walters K J; Dayie K T; Reece R J; Ptashne M; Wagner G
Structure and mobility of the PUT3 dimer.
Nature structural biology 1997;4(9):744-50.
1997: Ptashne M; Gann A
Transcriptional activation by recruitment.
Nature 1997;386(6625):569-77.
1997: Gaudreau L; Schmid A; Blaschke D; Ptashne M; Hörz W
RNA polymerase II holoenzyme recruitment is sufficient to remodel chromatin at the yeast PHO5 promoter.
Cell 1997;89(1):55-62.
1997: Whipple F W; Ptashne M; Hochschild A
The activation defect of a lambda cI positive control mutant.
Journal of molecular biology 1997;265(3):261-5.
1996: Farrell S; Simkovich N; Wu Y; Barberis A; Ptashne M
Gene activation by recruitment of the RNA polymerase II holoenzyme.
Genes & development 1996;10(18):2359-67.
1996: Wu Y; Reece R J; Ptashne M
Quantitation of putative activator-target affinities predicts transcriptional activating potentials.
The EMBO journal 1996;15(15):3951-63.
1996: Liang S D; Marmorstein R; Harrison S C; Ptashne M
DNA sequence preferences of GAL4 and PPR1: how a subset of Zn2 Cys6 binuclear cluster proteins recognizes DNA.
Molecular and cellular biology 1996;16(7):3773-80.
1995: Lehming N; McGuire S; Brickman J M; Ptashne M
Interactions of a Rel protein with its inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10242-6.
1995: Astromoff A; Ptashne M
A variant of lambda repressor with an altered pattern of cooperative binding to DNA sites.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8110-4.
1995: Barberis A; Pearlberg J; Simkovich N; Farrell S; Reinagel P; Bamdad C; Sigal G; Ptashne M
Contact with a component of the polymerase II holoenzyme suffices for gene activation.
Cell 1995;81(3):359-68.
1994: Lehming N; Thanos D; Brickman J M; Ma J; Maniatis T; Ptashne M
An HMG-like protein that can switch a transcriptional activator to a repressor.
Nature 1994;371(6493):175-9.
1993: Reece R J; Ptashne M
Determinants of binding-site specificity among yeast C6 zinc cluster proteins.
Science (New York, N.Y.) 1993;261(5123):909-11.
1993: Barberis A; Müller C W; Harrison S C; Ptashne M
Delineation of two functional regions of transcription factor TFIIB.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5628-32.
1993: Saha S; Brickman J M; Lehming N; Ptashne M
New eukaryotic transcriptional repressors.
Nature 1993;363(6430):648-52.
1993: Baumann R; Grogan E; Ptashne M; Miller G
Changing Epstein-Barr viral ZEBRA protein into a more powerful activator enhances its capacity to disrupt latency.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4436-40.
1993: Reece R J; Rickles R J; Ptashne M
Overproduction and single-step purification of GAL4 fusion proteins from Escherichia coli.
Gene 1993;126(1):105-7.
1992: Lamphier M S; Ptashne M
Multiple mechanisms mediate glucose repression of the yeast GAL1 gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):5922-6.
1992: Marmorstein R; Carey M; Ptashne M; Harrison S C
DNA recognition by GAL4: structure of a protein-DNA complex.
Nature 1992;356(6368):408-14.
1992: Guarante L; Roberts T M; Ptashne M
A technique for expressing eukaryotic genes in bacteria. 1980.
Biotechnology (Reading, Mass.) 1992;24():261-3.
1991: Sadowski I; Niedbala D; Wood K; Ptashne M
GAL4 is phosphorylated as a consequence of transcriptional activation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10510-4.
1991: Ptashne M S
Alfred P. Sloan, Jr. Prize. Gene regulation.
Cancer 1991;67(10):2422-7.
1991: Ruden D M; Ma J; Li Y; Wood K; Ptashne M
Generating yeast transcriptional activators containing no yeast protein sequences.
Nature 1991;350(6315):250-2.
1990: Himmelfarb H J; Pearlberg J; Last D H; Ptashne M
GAL11P: a yeast mutation that potentiates the effect of weak GAL4-derived activators.
Cell 1990;63(6):1299-309.
1990: Ptashne M; Gann A A
Activators and targets.
Nature 1990;346(6282):329-31.
1990: Lin Y S; Carey M; Ptashne M; Green M R
How different eukaryotic transcriptional activators can cooperate promiscuously.
Nature 1990;345(6273):359-61.
1990: Carey M; Lin Y S; Green M R; Ptashne M
A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives.
Nature 1990;345(6273):361-4.
1990: Gill G; Sadowski I; Ptashne M
Mutations that increase the activity of a transcriptional activator in yeast and mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2127-31.
1990: Carey M; Leatherwood J; Ptashne M
A potent GAL4 derivative activates transcription at a distance in vitro.
Science (New York, N.Y.) 1990;247(4943):710-2.
1989: Valenzuela D; Ptashne M
P22 repressor mutants deficient in co-operative binding and DNA loop formation.
The EMBO journal 1989;8(13):4345-50.
1989: Chasman D I; Leatherwood J; Carey M; Ptashne M; Kornberg R D
Activation of yeast polymerase II transcription by herpesvirus VP16 and GAL4 derivatives in vitro.
Molecular and cellular biology 1989;9(11):4746-9.
1989: Driever W; Ma J; Nüsslein-Volhard C; Ptashne M
Rescue of bicoid mutant Drosophila embryos by bicoid fusion proteins containing heterologous activating sequences.
Nature 1989;342(6246):149-54.
1989: Carey M; Kakidani H; Leatherwood J; Mostashari F; Ptashne M
An amino-terminal fragment of GAL4 binds DNA as a dimer.
Journal of molecular biology 1989;209(3):423-32.
1989: Sadowski I; Ptashne M
A vector for expressing GAL4(1-147) fusions in mammalian cells.
Nucleic acids research 1989;17(18):7539.
1989: Bushman F D; Shang C; Ptashne M
A single glutamic acid residue plays a key role in the transcriptional activation function of lambda repressor.
Cell 1989;58(6):1163-71.
1989: Ptashne M
How gene activators work.
Scientific American 1989;260(1):40-7.
1988: Aggarwal A K; Rodgers D W; Drottar M; Ptashne M; Harrison S C
Recognition of a DNA operator by the repressor of phage 434: a view at high resolution.
Science (New York, N.Y.) 1988;242(4880):899-907.
1988: Ma J; Ptashne M
Converting a eukaryotic transcriptional inhibitor into an activator.
Cell 1988;55(3):443-6.
1988: Hochschild A; Ptashne M
Interaction at a distance between lambda repressors disrupts gene activation.
Nature 1988;336(6197):353-7.
1988: Wolberger C; Dong Y C; Ptashne M; Harrison S C
Structure of a phage 434 Cro/DNA complex.
Nature 1988;335(6193):789-95.
1988: Ptashne M
How eukaryotic transcriptional activators work.
Nature 1988;335(6192):683-9.
1988: Sadowski I; Ma J; Triezenberg S; Ptashne M
GAL4-VP16 is an unusually potent transcriptional activator.
Nature 1988;335(6190):563-4.
1988: Hollis M; Valenzuela D; Pioli D; Wharton R; Ptashne M
A repressor heterodimer binds to a chimeric operator.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5834-8.
1988: Gill G; Ptashne M
Negative effect of the transcriptional activator GAL4.
Nature 1988;334(6184):721-4.
1988: Ma J; Przibilla E; Hu J; Bogorad L; Ptashne M
Yeast activators stimulate plant gene expression.
Nature 1988;334(6183):631-3.
1988: Lin Y S; Carey M F; Ptashne M; Green M R
GAL4 derivatives function alone and synergistically with mammalian activators in vitro.
Cell 1988;54(5):659-64.
1988: Koudelka G B; Harbury P; Harrison S C; Ptashne M
DNA twisting and the affinity of bacteriophage 434 operator for bacteriophage 434 repressor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4633-7.
1988: Bushman F D; Ptashne M
Turning lambda Cro into a transcriptional activator.
Cell 1988;54(2):191-7.
1988: Ruden D M; Ma J; Ptashne M
No strict alignment is required between a transcriptional activator binding site and the "TATA box" of a yeast gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4262-6.
1988: Fischer J A; Giniger E; Maniatis T; Ptashne M
GAL4 activates transcription in Drosophila.
Nature 1988;332(6167):853-6.
1988: Harrison S C; Anderson J E; Koudelka G B; Mondragon A; Subbiah S; Wharton R P; Wolberger C; Ptashne M
Recognition of DNA sequences by the repressor of bacteriophage 434.
Biophysical chemistry 1988;29(1-2):31-7.
1988: Giniger E; Ptashne M
Cooperative DNA binding of the yeast transcriptional activator GAL4.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):382-6.
1988: Kakidani H; Ptashne M
GAL4 activates gene expression in mammalian cells.
Cell 1988;52(2):161-7.
1987: Giniger E; Ptashne M
Transcription in yeast activated by a putative amphipathic alpha helix linked to a DNA binding unit.
Nature 1987;330(6149):670-2.
1987: Irwin N; Ptashne M
Mutants of the catabolite activator protein of Escherichia coli that are specifically deficient in the gene-activation function.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8315-9.
1987: Gill G; Ptashne M
Mutants of GAL4 protein altered in an activation function.
Cell 1987;51(1):121-6.
1987: Ma J; Ptashne M
A new class of yeast transcriptional activators.
Cell 1987;51(1):113-9.
1987: Ma J; Ptashne M
The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80.
Cell 1987;50(1):137-42.
1987: Wharton R P; Ptashne M
A new-specificity mutant of 434 repressor that defines an amino acid-base pair contact.
Nature 1987;326(6116):888-91.
1987: Koudelka G B; Harrison S C; Ptashne M
Effect of non-contacted bases on the affinity of 434 operator for 434 repressor and Cro.
Nature 1987;326(6116):886-8.
1987: Anderson J E; Ptashne M; Harrison S C
Structure of the repressor-operator complex of bacteriophage 434.
Nature 1987;326(6116):846-52.
1987: Ma J; Ptashne M
Deletion analysis of GAL4 defines two transcriptional activating segments.
Cell 1987;48(5):847-53.
1986: Bushman F D; Ptashne M
Activation of transcription by the bacteriophage 434 repressor.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9353-7.
1986: Silver P A; Brent R; Ptashne M
DNA binding is not sufficient for nuclear localization of regulatory proteins in Saccharomyces cerevisiae.
Molecular and cellular biology 1986;6(12):4763-6.
1986: Hochschild A; Douhan J; Ptashne M
How lambda repressor and lambda Cro distinguish between OR1 and OR3.
Cell 1986;47(5):807-16.
1986: Griffith J; Hochschild A; Ptashne M
DNA loops induced by cooperative binding of lambda repressor.
Nature 1986;322(6081):750-2.
1986: Ptashne M
Gene regulation by proteins acting nearby and at a distance.
Nature 1986;322(6081):697-701.
1986: Sharon J; Gefter M L; Manser T; Ptashne M
Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibody.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2628-31.
1986: Hochschild A; Ptashne M
Homologous interactions of lambda repressor and lambda Cro with the lambda operator.
Cell 1986;44(6):925-33.
1986: Hochschild A; Ptashne M
Cooperative binding of lambda repressors to sites separated by integral turns of the DNA helix.
Cell 1986;44(5):681-7.
1986: Keegan L; Gill G; Ptashne M
Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein.
Science (New York, N.Y.) 1986;231(4739):699-704.
1985: Brent R; Ptashne M
A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor.
Cell 1985;43(3 Pt 2):729-36.
1985: Bushman F D; Anderson J E; Harrison S C; Ptashne M
Ethylation interference and X-ray crystallography identify similar interactions between 434 repressor and operator.
Nature 1985;316(6029):651-3.
1985: Wharton R P; Ptashne M
Changing the binding specificity of a repressor by redesigning an alpha-helix.
Nature 1985;316(6029):601-5.
1985: Anderson J E; Ptashne M; Harrison S C
A phage repressor-operator complex at 7 A resolution.
Nature 1985;316(6029):596-601.
1985: Giniger E; Varnum S M; Ptashne M
Specific DNA binding of GAL4, a positive regulatory protein of yeast.
Cell 1985;40(4):767-74.
1985: Eliason J L; Weiss M A; Ptashne M
NH2-terminal arm of phage lambda repressor contributes energy and specificity to repressor binding and determines the effects of operator mutations.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(8):2339-43.
1985: Brent R; Ptashne M
A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene.
Nature 1985;314(6007):198.
1984: Brent R; Ptashne M
A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene.
Nature 1984;312(5995):612-5.
1984: West R W; Yocum R R; Ptashne M
Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASG.
Molecular and cellular biology 1984;4(11):2467-78.
1984: Yocum R R; Hanley S; West R; Ptashne M
Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.
Molecular and cellular biology 1984;4(10):1985-98.
1984: Kimelman D; Lucher L A; Brackmann K H; Symington J S; Ptashne M; Green M
Synthesis in Escherichia coli of human adenovirus type 12 transforming proteins encoded by early region 1A 13S mRNA and 12S mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(20):6300-4.
1984: Silver P A; Keegan L P; Ptashne M
Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(19):5951-5.
1984: Wharton R P; Brown E L; Ptashne M
Substituting an alpha-helix switches the sequence-specific DNA interactions of a repressor.
Cell 1984;38(2):361-9.
1984: Sharon J; Gefter M L; Manser T; Morrison S L; Oi V T; Ptashne M
Expression of a VHC kappa chimaeric protein in mouse myeloma cells.
Nature 1984;309(5966):364-7.
1984: Ptashne M
DNA-binding proteins.
Nature 1984;308(5961):753-4.
1984: Anderson J; Ptashne M; Harrison S C
Cocrystals of the DNA-binding domain of phage 434 repressor and a synthetic phage 434 operator.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(5):1307-11.
1983: Amann E; Brosius J; Ptashne M
Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli.
Gene 1983;25(2-3):167-78.
1983: Hochschild A; Irwin N; Ptashne M
Repressor structure and the mechanism of positive control.
Cell 1983;32(2):319-25.
1983: Lewis M; Jeffrey A; Wang J; Ladner R; Ptashne M; Pabo C O
Structure of the operator-binding domain of bacteriophage lambda repressor: implications for DNA recognition and gene regulation.
Cold Spring Harbor symposia on quantitative biology 1983;47 Pt 1():435-40.
1982: Ptashne M; Johnson A D; Pabo C O
A genetic switch in a bacterial virus.
Scientific American 1982;247(5):128-30, 132, 134-40.
1982: Kenyon C J; Brent R; Ptashne M; Walker G C
Regulation of damage-inducible genes in Escherichia coli.
Journal of molecular biology 1982;160(3):445-57.
1982: Zinn K; Mellon P; Ptashne M; Maniatis T
Regulated expression of an extrachromosomal human beta-interferon gene in mouse cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(16):4897-901.
1982: Poteete A R; Ptashne M
Control of transcription by the bacteriophage P22 repressor.
Journal of molecular biology 1982;157(1):21-48.
1982: Sauer R T; Ross M J; Ptashne M
Cleavage of the lambda and P22 repressors by recA protein.
The Journal of biological chemistry 1982;257(8):4458-62.
1982: Guarente L; Nye J S; Hochschild A; Ptashne M
Mutant lambda phage repressor with a specific defect in its positive control function.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(7):2236-9.
1981: Johnson A D; Poteete A R; Lauer G; Sauer R T; Ackers G K; Ptashne M
lambda Repressor and cro--components of an efficient molecular switch.
Nature 1981;294(5838):217-23.
1981: Brent R; Ptashne M
Mechanism of action of the lexA gene product.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4204-8.
1981: Guarente L; Ptashne M
Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(4):2199-203.
1981: Lauer G; Pastrana R; Sherley J; Ptashne M
Construction of overproducers of the bacteriophage 434 repressor and cro proteins.
Journal of molecular and applied genetics 1981;1(2):139-47.
1980: Taniguchi T; Guarente L; Roberts T M; Kimelman D; Douhan J; Ptashne M
Expression of the human fibroblast interferon gene in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(9):5230-3.
1980: Guarente L; Roberts T M; Ptashne M
A technique for expressing eukaryotic genes in bacteria.
Science (New York, N.Y.) 1980;209(4463):1428-30.
1980: Guarente L; Lauer G; Roberts T M; Ptashne M
Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit beta-globin.
Cell 1980;20(2):543-53.
1980: Meyer B J; Ptashne M
Gene regulation at the right operator (OR) of bacteriophage lambda. III. lambda repressor directly activates gene transcription.
Journal of molecular biology 1980;139(2):195-205.
1980: Meyer B J; Maurer R; Ptashne M
Gene regulation at the right operator (OR) of bacteriophage lambda. II. OR1, OR2, and OR3: their roles in mediating the effects of repressor and cro.
Journal of molecular biology 1980;139(2):163-94.
1980: Maurer R; Meyer B; Ptashne M
Gene regulation at the right operator (OR) bacteriophage lambda. I. OR3 and autogenous negative control by repressor.
Journal of molecular biology 1980;139(2):147-61.
1980: Brent R; Ptashne M
The lexA gene product represses its own promoter.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(4):1932-6.
1980: Poteete A R; Ptashne M; Ballivet M; Eisen H
Operator sequences of bacteriophages P22 and 21.
Journal of molecular biology 1980;137(1):81-91.
1980: Ptashne M; Jeffrey A; Johnson A D; Maurer R; Meyer B J; Pabo C O; Roberts T M; Sauer R T
How the lambda repressor and cro work.
Cell 1980;19(1):1-11.
1979: Roberts T M; Bikel I; Yocum R R; Livingston D M; Ptashne M
Synthesis of simian virus 40 t antigen in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(11):5596-600.
1979: Johnson A D; Meyer B J; Ptashne M
Interactions between DNA-bound repressors govern regulation by the lambda phage repressor.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(10):5061-5.
1979: Sauer R T; Pabo C O; Meyer B J; Ptashne M; Backman K C
Regulatory functions of the lambda repressor reside in the amino-terminal domain.
Nature 1979;279(5712):396-400.
1979: Pabo C O; Sauer R T; Sturtevant J M; Ptashne M
The lambda repressor contains two domains.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(4):1608-12.
1979: Roberts T M; Kacich R; Ptashne M
A general method for maximizing the expression of a cloned gene.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(2):760-4.
1978: Johnson A; Meyer B J; Ptashne M
Mechanism of action of the cro protein of bacteriophage lambda.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(4):1783-7.
1978: Backman K; Ptashne M
Maximizing gene expression on a plasmid using recombination in vitro.
Cell 1978;13(1):65-71.
1977: Humayun Z; Jeffrey A; Ptashne M
Completed DNA sequences and organization of repressor-binding sites in the operators of phage lambda.
Journal of molecular biology 1977;112(2):265-77.
1977: Humayun Z; Kleid D; Ptashne M
Sites of contact between lambda operators and lambda repressor.
Nucleic acids research 1977;4(5):1595-607.
1976: Backman K; Ptashne M; Gilbert W
Construction of plasmids carrying the cI gene of bacteriophage lambda.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(11):4174-8.
1976: Ptashne M; Backman K; Humayun M Z; Jeffrey A; Maurer R; Meyer B; Sauer R T
Autoregulation and function of a repressor in bacteriophage lambda.
Science (New York, N.Y.) 1976;194(4261):156-61.
1976: Kleid D; Humayun Z; Jeffrey A; Ptashne M
Novel properties of a restriction endonuclease isolated from Haemophilus parahaemolyticus.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(2):293-7.
1976: Maniatis T; Ptashne M
A DNA operator-repressor system.
Scientific American 1976;234(1):64-6, 71-6.
1975: Meyer B J; Kleid D G; Ptashne M
Lambda repressor turns off transcription of its own gene.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(12):4785-89.
1975: Maniatis T; Ptashne M; Backman K; Kield D; Flashman S; Jeffrey A; Maurer R
Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda.
Cell 1975;5(2):109-13.
1974: Maniatis T; Ptashne M; Barrell B G; Donelson J
Sequence of a repressor-binding site in the DNA of bacteriophage lamda.
Nature 1974;250(465):394-7.
1974: Maurer R; Maniatis T; Ptashne M
Promoters are in the operators in phage lambda.
Nature 1974;249(454):221-3.
1974: Maniatis T; Ptashne M; Maurer R
Control elements in the DNA of bacteriophage lambda.
Cold Spring Harbor symposia on quantitative biology 1974;38():857-68.
1973: Maniatis T; Ptashne M
Structure of the lambda operators.
Nature 1973;246(5429):133-6.
1973: Maniatis T; Ptashne M
Multiple repressor binding at the operators in bacteriophage lambda.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(5):1531-5.
1973: Ptashne M
Repressor, operators, and promoters in bacteriophage lambda.
Harvey lectures 1973;(69):143-71.
1971: Steinberg R A; Ptashne M
In vitro repression of RNA synthesis by purified lambda phage repressor.
Nature: New biology 1971;230(11):76-80.
1971: Ptashne M
Phage repressors. In: strategy of the viral genome.
Ciba Foundation symposium 1971;():155-68.
1970: Pirrotta V; Chadwick P; Ptashne M
Active form of two coliphage repressors.
Nature 1970;227(5253):41-4.
1970: Ptashne M; Gilbert W
Genetic repressors.
Scientific American 1970;222(6):36-44.
1969: Pirrotta V; Ptashne M
Isolation of the 434 phage repressor.
Nature 1969;222(5193):541-4.
1968: Ptashne M; Hopkins N
The operators controlled by the lambda phage repressor.
Proceedings of the National Academy of Sciences of the United States of America 1968;60(4):1282-7.
1967: Ptashne M
Specific binding of the lambda phage repressor to lambda DNA.
Nature 1967;214(5085):232-4.
1965: PTASHNE M
REPLICATION AND HOST MODIFICATION OF DNA TRANSFERRED DURING BACTERIAL MATING.
Journal of molecular biology 1965;11():829-38.
1965: PTASHNE M
THE DETACHMENT AND MATURATION OF CONSERVED LAMBDA PROPHAGE DNA.
Journal of molecular biology 1965;11():90-6.
1960: Ptashne M
The Behavior of Strong and Weak Centromeres at Second Anaphase of Drosophila Melanogaster.
Genetics 1960;45(4):499-506.

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