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Christopher Pugh

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Johannes Schödel; Lina K Sciesielski; Ian P Tomlinson; Christopher W Pugh; Peter J Ratcliffe; Chiara Bardella; Jill M Brown; Veronica Buckle; David R Mole
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.
Jennifer A Hirst; Christopher W Pugh; Nia W Roberts; Richard J Stevens; Kathryn S Taylor; Claire L Blacklock; Andrew Farmer
The impact of renin-angiotensin-aldosterone system inhibitors on Type 1 and Type 2 diabetic patients with and without early diabetic nephropathy.
Julie Adam; Dilair Baban; Peter Carmeliet; Mona El-Bahrawy; Roman Fischer; Norma Frizzell; Emine Hatipoglu; Benedikt M Kessler; Helen Lockstone; Patrick H Maxwell; Emma Nye; Linda O'Flaherty; Christopher W Pugh; Peter J Ratcliffe; Natasha Sahgal; Tomoyoshi Soga; Gordon W Stamp; Marcus Stevens; Nicola Ternette; Kathryn Wolhuter; Patrick J Pollard
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.

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2012: Johannes Schödel; Lina K Sciesielski; Ian P Tomlinson; Christopher W Pugh; Peter J Ratcliffe; Chiara Bardella; Jill M Brown; Veronica Buckle; David R Mole
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.
Nature genetics 2012;44(4):420-5, S1-2.
2012: Jennifer A Hirst; Christopher W Pugh; Nia W Roberts; Richard J Stevens; Kathryn S Taylor; Claire L Blacklock; Andrew Farmer
The impact of renin-angiotensin-aldosterone system inhibitors on Type 1 and Type 2 diabetic patients with and without early diabetic nephropathy.
Kidney international 2012;81(7):674-83.
2011: Julie Adam; Dilair Baban; Peter Carmeliet; Mona El-Bahrawy; Roman Fischer; Norma Frizzell; Emine Hatipoglu; Benedikt M Kessler; Helen Lockstone; Patrick H Maxwell; Emma Nye; Linda O'Flaherty; Christopher W Pugh; Peter J Ratcliffe; Natasha Sahgal; Tomoyoshi Soga; Gordon W Stamp; Marcus Stevens; Nicola Ternette; Kathryn Wolhuter; Patrick J Pollard
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
Cancer cell 2011;20(4):524-37.
2011: Chiara Bardella; John W Baynes; Ashish Chandra; Mona El-Bahrawy; Norma Frizzell; Konstantinos Giaslakiotis; Adrian L Harris; Emine Hatipoglu; Kimberley Howarth; Benedikt Kessler; Virpi Launonen; Heli J Lehtonen; Valentine M Macaulay; Radu Mihai; Linda O'Flaherty; Christopher W Pugh; Peter J Ratcliffe; Ian Roberts; Jennifer Taylor; Nicola Ternette; Ian P M Tomlinson; David Trudgian; Gareth Turner; Lauri A Aaltonen; Julie Adam; Patrick J Pollard
Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.
The Journal of pathology 2011;225(1):4-11.
2011: Johannes Schödel; Spyros Oikonomopoulos; Christopher W Pugh; Jiannis Ragoussis; Peter J Ratcliffe; David R Mole
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.
Blood 2011;117(23):e207-17.
2011: Federico Formenti; Philip A Beer; Quentin P P Croft; Keith L Dorrington; Daniel P Gale; Terence R J Lappin; Guy S Lucas; Eamonn R Maher; Patrick H Maxwell; Mary F McMullin; David F O'Connor; Melanie J Percy; Christopher W Pugh; Peter J Ratcliffe; Thomas G Smith; Nick P Talbot; Peter A Robbins
Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(6):2001-11.
2011: Ya-Min Tian; Kar Kheng Yeoh; Myung Kyu Lee; Tuula Eriksson; Benedikt M Kessler; Holger B Kramer; Mariola J Edelmann; Carsten Willam; Christopher W Pugh; Christopher J Schofield; Peter J Ratcliffe
Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
The Journal of biological chemistry 2011;286(15):13041-51.
2011: Samira Lakhal; Johannes Schödel; Alain R M Townsend; Christopher W Pugh; Peter J Ratcliffe; David R Mole
Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.
The Journal of biological chemistry 2011;286(6):4090-7.
2009: James D Webb; Mathew L Coleman; Christopher W Pugh
Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
Cellular and molecular life sciences : CMLS 2009;66(22):3539-54.
2009: James D Webb; Andrea Murányi; Christopher W Pugh; Peter J Ratcliffe; Mathew L Coleman
MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
The Biochemical journal 2009;420(2):327-33.
2009: Samira Lakhal; Nick P Talbot; Alexi Crosby; Chantal Stoepker; Alain R M Townsend; Peter A Robbins; Christopher W Pugh; Peter J Ratcliffe; David R Mole
Regulation of growth differentiation factor 15 expression by intracellular iron.
Blood 2009;113(7):1555-63.
2008: Tammie Bishop; Denis Gallagher; Alberto Pascual; Craig A Lygate; Joseph P de Bono; Lynn G Nicholls; Patricia Ortega-Saenz; Henrik Oster; Bhathiya Wijeyekoon; Andrew I Sutherland; Alexandra Grosfeld; Julian Aragones; Martin Schneider; Katie van Geyte; Dania Teixeira; Antonio Diez-juan; Jose Lopez-Barneo; Keith M Channon; Patrick H Maxwell; Christopher W Pugh; Alun M Davies; Peter Carmeliet; Peter J Ratcliffe
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
Molecular and cellular biology 2008;28(10):3386-400.
2008: Thomas G Smith; J T Brooks; George M Balanos; Terence R J Lappin; D M Layton; D L Leedham; C Liu; Patrick H Maxwell; M F McMullin; C J McNamara; M J Percy; Christopher W Pugh; Peter J Ratcliffe; Nick P Talbot; Marilyn Treacy; Peter A Robbins
Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology.
Advances in experimental medicine and biology 2008;605():51-6.
2007: J S P Yuen; Matthew E Cockman; M Sullivan; Andrew Protheroe; Gareth D H Turner; Ian S D Roberts; Christopher W Pugh; H Werner; Valentine M Macaulay
The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma.
Oncogene 2007;26(45):6499-508.
2007: Alexandra Grosfeld; Ineke P Stolze; Matthew E Cockman; Christopher W Pugh; Mariola Edelmann; Benedikt Kessler; Alex N Bullock; Peter J Ratcliffe; Norma Masson
Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.
The Journal of biological chemistry 2007;282(18):13264-9.
2007: Kah Weng Lau; Ya-Min Tian; Raju R Raval; Peter J Ratcliffe; Christopher W Pugh
Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.
British journal of cancer 2007;96(8):1284-92.
2006: Matthew E Cockman; David E Lancaster; Ineke P Stolze; Kirsty S Hewitson; Michael McDonough; Mathew L Coleman; Charlotte H Coles; Xiaohong Yu; Ron Thomas Hay; Steven C Ley; Christopher W Pugh; Neil J Oldham; Norma Masson; Christopher J Schofield; Peter J Ratcliffe
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
Proceedings of the National Academy of Sciences of the United States of America 2006;103(40):14767-72.
2006: Dylan T Jones; Christopher W Pugh; Simon Wigfield; Malcolm F G Stevens; Adrian L Harris
Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5384-94.
2006: Thomas G Smith; Jerome T Brooks; George M Balanos; Terence R J Lappin; D Mark Layton; Dawn L Leedham; Chun Liu; Patrick H Maxwell; Mary Frances McMullin; Christopher J McNamara; Melanie J Percy; Christopher W Pugh; Peter J Ratcliffe; Nick P Talbot; Marilyn Treacy; Peter A Robbins
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.
PLoS medicine 2006;3(7):e290.
2006: Carsten Willam; Patrick H Maxwell; Lynn Nichols; Craig A Lygate; Ya-Min Tian; Wanja M Bernhardt; Michael S Wiesener; Peter J Ratcliffe; Kai-Uwe Eckardt; Christopher W Pugh
HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
Journal of molecular and cellular cardiology 2006;41(1):68-77.
2006: Jonathan Gleadle; David R Mole; Christopher W Pugh
Hypoxia-inducible factors: where, when and why?
Kidney international 2006;69(1):15-7.
2005: E J Soilleux; Helen Turley; Ya-Min Tian; Christopher W Pugh; Kevin C Gatter; Adrian L Harris
Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues.
Histopathology 2005;47(6):602-10.
2005: Raju R Raval; Kah Weng Lau; Maxine G B Tran; Heidi M Sowter; Stefano J Mandriota; Ji-Liang Li; Christopher W Pugh; Patrick H Maxwell; Adrian L Harris; Peter J Ratcliffe
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
Molecular and cellular biology 2005;25(13):5675-86.
2005: Matthew E Cockman; Christopher W Pugh
Oxygen sensing.
Haematologica 2005;90(1):8-12.
2004: David E Lancaster; Luke A McNeill; Michael McDonough; Robin T Aplin; Kirsty S Hewitson; Christopher W Pugh; Peter J Ratcliffe; Christopher J Schofield
Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.
The Biochemical journal 2004;383(Pt. 3):429-37.
2004: Jason R Tuckerman; Yuguang Zhao; Kirsty S Hewitson; Ya-Min Tian; Christopher W Pugh; Peter J Ratcliffe; David R Mole
Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
FEBS letters 2004;576(1-2):145-50.
2004: Tammie Bishop; Kah Weng Lau; Andrew C R Epstein; Stuart K Kim; Min Jiang; Delia O'Rourke; Christopher W Pugh; Jonathan Gleadle; Martin Taylor; Jonathan Hodgkin; Peter J Ratcliffe
Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.
PLoS biology 2004;2(10):e289.
2004: Rebecca J Appelhoff; Ya-Min Tian; Raju R Raval; Helen Turley; Adrian L Harris; Christopher W Pugh; Peter J Ratcliffe; Jonathan Gleadle
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
The Journal of biological chemistry 2004;279(37):38458-65.
2004: Norma Masson; Rebecca J Appelhoff; Jason R Tuckerman; Ya-Min Tian; Hans Demol; Magda Puype; Joël Vandekerckhove; Peter J Ratcliffe; Christopher W Pugh
The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
FEBS letters 2004;570(1-3):166-70.
2004: Carsten Willam; Lynn G Nicholls; Peter J Ratcliffe; Christopher W Pugh; Patrick H Maxwell
The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha.
Advances in enzyme regulation 2004;44():75-92.
2003: David R Mole; Imre Schlemminger; Luke A McNeill; Kirsty S Hewitson; Christopher W Pugh; Peter J Ratcliffe; Christopher J Schofield
2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
Bioorganic & medicinal chemistry letters 2003;13(16):2677-80.
2003: Christopher W Pugh; Peter J Ratcliffe
Regulation of angiogenesis by hypoxia: role of the HIF system.
Nature medicine 2003;9(6):677-84.
2003: Imre Schlemminger; David R Mole; Luke A McNeill; Anupma Dhanda; Kirsty S Hewitson; Ya-Min Tian; Peter J Ratcliffe; Christopher W Pugh; Christopher J Schofield
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
Bioorganic & medicinal chemistry letters 2003;13(8):1451-4.
2003: Christopher W Pugh; Peter John Ratcliffe
The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
Seminars in cancer biology 2003;13(1):83-9.
2003: Michael S Wiesener; Jan Steffen Jürgensen; Christian Rosenberger; Charlotte K Scholze; Jan H Hörstrup; Christina Warnecke; Stefano J Mandriota; Ingo Bechmann; Ulrich Frei; Christopher W Pugh; Peter J Ratcliffe; Sebastian Bachmann; Patrick H Maxwell; Kai-Uwe Eckardt
Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):271-3.
2003: Jonathan M Elkins; Kirsty S Hewitson; Luke A McNeill; Jurgen F Seibel; Imre Schlemminger; Christopher W Pugh; Peter J Ratcliffe; Christopher J Schofield
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
The Journal of biological chemistry 2003;278(3):1802-6.
2003: Christopher W Pugh
Oxygen sensing in cancer.
Annals of medicine 2003;35(6):380-90.
2002: Carsten Willam; Norma Masson; Ya-Min Tian; S Aleema Mahmood; Michael I Wilson; Roy Bicknell; Kai-Uwe Eckardt; Patrick H Maxwell; Peter J Ratcliffe; Christopher W Pugh
Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10423-8.
2002: Kirsty S Hewitson; Luke A McNeill; Madeline V Riordan; Ya-Min Tian; Alex N Bullock; Richard W D Welford; Jonathan M Elkins; Neil J Oldham; Shoumo Bhattacharya; Jonathan Gleadle; Peter J Ratcliffe; Christopher W Pugh; Christopher J Schofield
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
The Journal of biological chemistry 2002;277(29):26351-5.
2002: Wai-Ching Hon; Michael I Wilson; Karl Harlos; Timothy D W Claridge; Christopher J Schofield; Christopher W Pugh; Patrick H Maxwell; Peter J Ratcliffe; David I Stuart; E Yvonne Jones
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Nature 2002;417(6892):975-8.
2002: Luke A McNeill; Kirsty S Hewitson; Jonathan Gleadle; Louise E Horsfall; Neil J Oldham; Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe; Christopher J Schofield
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
Bioorganic & medicinal chemistry letters 2002;12(12):1547-50.
2002: David R Mole; Christopher W Pugh; Peter J Ratcliffe; Patrick H Maxwell
Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
Advances in enzyme regulation 2002;42():333-47.
2001: EC Vaux; SM Wood; Matthew E Cockman; Lynn G Nicholls; KM Yeates; Christopher W Pugh; Patrick H Maxwell; Peter J Ratcliffe
Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor.
The Journal of biological chemistry 2001;276(47):44323-30.
2001: Andrew C R Epstein; Jonathan Gleadle; Luke A McNeill; Kirsty S Hewitson; JF O'Rourke; David R Mole; Mridul Mukherji; Eric Metzen; Michael I Wilson; A Dhanda; Ya-Min Tian; Norma Masson; D L Hamilton; Panu M Jaakkola; R Barstead; Jonathan Hodgkin; Patrick H Maxwell; Christopher W Pugh; Christopher J Schofield; Peter J Ratcliffe
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Cell 2001;107(1):43-54.
2001: Norma Masson; Carsten Willam; Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.
The EMBO journal 2001;20(18):5197-206.
2001: David R Mole; Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe
Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
IUBMB life 2001;52(1-2):43-7.
2001: Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe
Activation of the HIF pathway in cancer.
Current opinion in genetics & development 2001;11(3):293-9.
2001: Panu M Jaakkola; David R Mole; Ya-Min Tian; Michael I Wilson; J Gielbert; S J Gaskell; Holger F Hebestreit; Mridul Mukherji; Christopher J Schofield; Patrick H Maxwell; Christopher W Pugh; A von Kriegsheim; Peter J Ratcliffe
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
Science (New York, N.Y.) 2001;292(5516):468-72.
2001: Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe
The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.
Advances in experimental medicine and biology 2001;502():365-76.
2001: Charles C Wykoff; Christopher W Pugh; Adrian L Harris; Patrick H Maxwell; Peter J Ratcliffe
The HIF pathway: implications for patterns of gene expression in cancer.
Novartis Foundation symposium 2001;240():212-25; discussion 225-31.
2001: Christopher W Pugh; Jonathan Gleadle; Patrick H Maxwell
Hypoxia and oxidative stress in breast cancer. Hypoxia signalling pathways.
Breast cancer research : BCR 2001;3(5):313-7.
2000: Charles C Wykoff; Nigel J P Beasley; Peter H Watson; Kevin J Turner; Jaromir Pastorek; Amen Sibtain; George D Wilson; Helen Turley; Kate L Talks; Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe; Adrian L Harris
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
Cancer research 2000;60(24):7075-83.
2000: Charles C Wykoff; Christopher W Pugh; Patrick H Maxwell; Adrian L Harris; Peter J Ratcliffe
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling.
Oncogene 2000;19(54):6297-305.
2000: Matthew E Cockman; Norma Masson; David R Mole; Panu M Jaakkola; GW Chang; Steven C Clifford; Eamonn R Maher; Christopher W Pugh; Peter J Ratcliffe; Patrick H Maxwell
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
The Journal of biological chemistry 2000;275(33):25733-41.
2000: Kate L Talks; Helen Turley; Kevin C Gatter; Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe; Adrian L Harris
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
The American journal of pathology 2000;157(2):411-21.
1999: Patrick H Maxwell; Michael S Wiesener; GW Chang; Steven C Clifford; EC Vaux; Matthew E Cockman; Charles C Wykoff; Christopher W Pugh; Eamonn R Maher; Peter J Ratcliffe
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
Nature 1999;399(6733):271-5.
1999: JF O'Rourke; Ya-Min Tian; Peter J Ratcliffe; Christopher W Pugh
Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.
The Journal of biological chemistry 1999;274(4):2060-71.
1999: Christopher W Pugh; GW Chang; Matthew E Cockman; Andrew C R Epstein; Jonathan Gleadle; Patrick H Maxwell; Lynn G Nicholls; JF O'Rourke; Peter J Ratcliffe; E C Raybould; Ya-Min Tian; Michael S Wiesener; M Wood; Charles C Wykoff; KM Yeates
Regulation of gene expression by oxygen levels in mammalian cells.
Advances in nephrology from the Necker Hospital 1999;29():191-206.
1998: Michael S Wiesener; Helen Turley; W E Allen; Carsten Willam; Kai-Uwe Eckardt; Kate L Talks; SM Wood; Kevin C Gatter; Adrian L Harris; Christopher W Pugh; Peter J Ratcliffe; Patrick H Maxwell
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
Blood 1998;92(7):2260-8.
1998: N C Bacon; Pablo Wappner; JF O'Rourke; S M Bartlett; Ben-Zion Shilo; Christopher W Pugh; Peter J Ratcliffe
Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha.
Biochemical and biophysical research communications 1998;249(3):811-6.
1998: SM Wood; Michael S Wiesener; KM Yeates; N Okada; Christopher W Pugh; Patrick H Maxwell; Peter J Ratcliffe
Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
The Journal of biological chemistry 1998;273(14):8360-8.
1998: Peter J Ratcliffe; JF O'Rourke; Patrick H Maxwell; Christopher W Pugh
Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.
The Journal of experimental biology 1998;201(Pt 8):1153-62.
1997: Peter J Ratcliffe; Patrick H Maxwell; Christopher W Pugh
Beyond erythropoietin: the oxygen sensor.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997;12(9):1842-8.
1997: Patrick H Maxwell; Gabi U Dachs; Jonathan Gleadle; Lynn G Nicholls; Adrian L Harris; Ian Stratford; O Hankinson; Christopher W Pugh; Peter J Ratcliffe
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8104-9.
1997: Christopher W Pugh; JF O'Rourke; M Nagao; Jonathan Gleadle; Peter J Ratcliffe
Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit.
The Journal of biological chemistry 1997;272(17):11205-14.
1997: Peter J Ratcliffe; B L Ebert; J D Firth; Jonathan Gleadle; Patrick H Maxwell; M Nagao; JF O'Rourke; Christopher W Pugh; SM Wood
Oxygen regulated gene expression: erythropoietin as a model system.
Kidney international 1997;51(2):514-26.
1997: Patrick H Maxwell; D J Ferguson; Lynn G Nicholls; J P Iredale; Christopher W Pugh; M H Johnson; Peter J Ratcliffe
Sites of erythropoietin production.
Kidney international 1997;51(2):393-401.
1997: JF O'Rourke; Gabi U Dachs; Jonathan Gleadle; Patrick H Maxwell; Christopher W Pugh; Ian Stratford; SM Wood; Peter J Ratcliffe
Hypoxia response elements.
Oncology research 1997;9(6-7):327-32.
1996: JF O'Rourke; Christopher W Pugh; S M Bartlett; Peter J Ratcliffe
Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1.
European journal of biochemistry / FEBS 1996;241(2):403-10.
1996: SM Wood; Jonathan Gleadle; Christopher W Pugh; O Hankinson; Peter J Ratcliffe
The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells.
The Journal of biological chemistry 1996;271(25):15117-23.
1996: M Nagao; B L Ebert; Peter J Ratcliffe; Christopher W Pugh
Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-binding sites.
FEBS letters 1996;387(2-3):161-6.
1995: Peter J Ratcliffe; B L Ebert; D J Ferguson; J D Firth; Jonathan Gleadle; Patrick H Maxwell; Christopher W Pugh
Regulation of the erythropoietin gene.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995;10 Suppl 2():18-27.
1994: Patrick H Maxwell; D J Ferguson; M K Osmond; Christopher W Pugh; A Heryet; B G Doe; M H Johnson; Peter J Ratcliffe
Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells.
Blood 1994;84(6):1823-30.
1994: J D Firth; B L Ebert; Christopher W Pugh; Peter J Ratcliffe
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6496-500.
1994: Kai-Uwe Eckardt; Christopher W Pugh; M Meier; C C Tan; P J Ratcliffe; A Kurtz
Production of erythropoietin by liver cells in vivo and in vitro.
Annals of the New York Academy of Sciences 1994;718():50-60; discussion 61-3.
1994: Patrick H Maxwell; M K Osmond; Christopher W Pugh; A Heryet; Lynn G Nicholls; C C Tan; B G Doe; D J Ferguson; M H Johnson; Peter J Ratcliffe
Erythropoietin-producing cells in transgenic mice expressing SV40 large T antigen directed by erythropoietin control sequences.
Annals of the New York Academy of Sciences 1994;718():356-8.
1994: Christopher W Pugh; B L Ebert; O Ebrahim; Patrick H Maxwell; Peter J Ratcliffe
Analysis of cis-acting sequences required for operation of the erythropoietin 3' enhancer in different cell lines.
Annals of the New York Academy of Sciences 1994;718():31-9; discussion 39-40.
1994: Christopher W Pugh; B L Ebert; O Ebrahim; P J Ratcliffe
Characterisation of functional domains within the mouse erythropoietin 3' enhancer conveying oxygen-regulated responses in different cell lines.
Biochimica et biophysica acta 1994;1217(3):297-306.
1993: Patrick H Maxwell; M K Osmond; Christopher W Pugh; A Heryet; Lynn G Nicholls; C C Tan; B G Doe; D J Ferguson; M H Johnson; Peter J Ratcliffe
Identification of the renal erythropoietin-producing cells using transgenic mice.
Kidney international 1993;44(5):1149-62.
1993: Kai-Uwe Eckardt; Christopher W Pugh; P J Ratcliffe; Armin Kurtz
Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro.
Pflügers Archiv : European journal of physiology 1993;423(5-6):356-64.
1993: Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe
Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2423-7.
1991: Christopher W Pugh; C C Tan; R W Jones; Peter J Ratcliffe
Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10553-7.