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Raj Puri

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Anatomy

Cultured Tumor Cells

Living Beings

Disorders

Procedures

Reverse Transcriptase Polymerase Chain Reaction

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Co-Publications
Name
35
Husain, Syed
35
Kawakami, Koji
28
Kawakami, Mariko
28
Leland, Pamela
25
Joshi, Bharat
24
Pastan, Ira
20
Obiri, NI
16
Kioi, Mitomu
14
Debinski, Waldemar
10
Kreitman, Robert
9
Hogaboam, Cory
8
Haas, Gabriel
8
Jakubzick, Claudia
8
Bhattacharya, Bhaskar
8
Murata, T

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Publications

TOP 3
Fujisawa Toshio; Joshi Bharat; Nakajima Atsushi; Puri Raj K
A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis.
Joshi Bharat H; Puri Raj K
Tumor immunology.
Bhattacharya Bhaskar; Puri Sachin; Puri Raj K
A review of gene expression profiling of human embryonic stem cell lines and their differentiated progeny.

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All Publications

2009: Fujisawa Toshio; Joshi Bharat; Nakajima Atsushi; Puri Raj K
A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis.
Cancer research 2009;69(22):8678-85.
2009: Joshi Bharat H; Puri Raj K
Tumor immunology.
Current molecular medicine 2009;9(6):665-6.
2009: Bhattacharya Bhaskar; Puri Sachin; Puri Raj K
A review of gene expression profiling of human embryonic stem cell lines and their differentiated progeny.
Current stem cell research & therapy 2009;4(2):98-106.
2009: Kioi Mitomu; Shimamura Takeshi; Nakashima Hideyuki; Hirota Makoto; Tohnai Iwai; Husain Syed R; Puri Raj K
IL-13 cytotoxin has potent antitumor activity and synergizes with paclitaxel in a mouse model of oral squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2009;124(6):1440-8.
2009: Han Jing; Kioi Mitomu; Chu Wei-Sing; Kasperbauer Jan L; Strome Scott E; Puri Raj K
Identification of potential therapeutic targets in human head & neck squamous cell carcinoma.
Head & neck oncology 2009;1(1):27.
2008: Joshi Bharat H; Leland Pamela; Calvo Alfonso; Green Jeffrey E; Puri Raj K
Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo: a novel approach to sensitize prostate cancer to anticancer therapy.
Cancer research 2008;68(22):9311-7.
2008: Shimamura Takeshi; Fujisawa Toshio; Husain Syed R; Kioi Mitomu; Nakajima Atsushi; Puri Raj K
Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4656-65.
2008: Lee Hin C; Kioi Mitomu; Han Jing; Puri Raj K; Goodman Jesse L
Anaplasma phagocytophilum-induced gene expression in both human neutrophils and HL-60 cells.
Genomics 2008;92(3):144-51.
2008: Kioi Mitomu; Seetharam Saraswathy; Puri Raj K
Targeting IL-13Ralpha2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin.
Molecular cancer therapeutics 2008;7(6):1579-87.
2008: Joshi Bharat H; Puri Rada A; Leland Pamela; Varricchio Frederick; Gupta Ghanshyam; Kocak Mehmet; Gilbertson Richard J; Puri Raj K;
Identification of interleukin-13 receptor alpha2 chain overexpression in situ in high-grade diffusely infiltrative pediatric brainstem glioma.
Neuro-oncology 2008;10(3):265-74.
2007: Vogelbaum Michael A; Sampson John H; Kunwar Sandeep; Chang Susan M; Shaffrey Mark; Asher Anthony L; Lang Frederick F; Croteau David; Parker Kristen; Grahn Amy Y; Sherman Jeffrey W; Husain S Rafat; Puri Raj K
Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety results.
Neurosurgery 2007;61(5):1031-7; discussion 1037-8.
2007: Shimamura Takeshi; Royal Richard E; Kioi Mitomu; Nakajima Atsushi; Husain Syed R; Puri Raj K
Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma.
Cancer research 2007;67(20):9903-12.
2007: Hsia Chu Chieh; Chizhikov Vladimir E; Yang Amy X; Selvapandiyan Angamuthu; Hewlett Indira; Duncan Robert; Puri Raj K; Nakhasi Hira L; Kaplan Gerardo G
Microarray multiplex assay for the simultaneous detection and discrimination of hepatitis B, hepatitis C, and human immunodeficiency type-1 viruses in human blood samples.
Biochemical and biophysical research communications 2007;356(4):1017-23.
2007: Kunwar Sandeep; Prados Michael D; Chang Susan M; Berger Mitchel S; Lang Frederick F; Piepmeier Joseph M; Sampson John H; Ram Zvi; Gutin Philip H; Gibbons Robert D; Aldape Kenneth D; Croteau David J; Sherman Jeffrey W; Puri Raj K;
Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(7):837-44.
2007: Sampson John H; Raghavan Raghu; Provenzale James M; Croteau David; Reardon David A; Coleman R Edward; Rodríguez Ponce Inmaculada; Pastan Ira; Puri Raj K; Pedain Christoph
Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin.
AJR. American journal of roentgenology 2007;188(3):703-9.
2007: Sampson John H; Brady Martin L; Petry Neil A; Croteau David; Friedman Allan H; Friedman Henry S; Wong Terence; Bigner Darell D; Pastan Ira; Puri Raj K; Pedain Christoph
Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.
Neurosurgery 2007;60(2 Suppl 1):ONS89-98; discussion ONS98-9.
2006: Yang Amy X; Mejido Josef; Bhattacharya Bhaskar; Petersen David; Han Jing; Kawasaki Ernest S; Puri Raj K
Analysis of the quality of contact-pin fabricated oligonucleotide microarrays.
Molecular biotechnology 2006;34(3):303-15.
2006: Kioi Mitomu; Seetharam Saraswathy; Puri Raj K
N-linked glycosylation of IL-13R alpha2 is essential for optimal IL-13 inhibitory activity.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(13):2378-80.
2006: Kioi Mitomu; Kawakami Mariko; Shimamura Takeshi; Husain Syed R; Puri Raj K
Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy.
Cancer 2006;107(6):1407-18.
2006: Kawakami Koji; Terabe Masaki; Kioi Mitomu; Berzofsky Jay A; Puri Raj K
Intratumoral therapy with IL13-PE38 results in effective CTL-mediated suppression of IL-13Ralpha2-expressing contralateral tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4678-86.
2006: Player Audrey; Wang Yonghong; Bhattacharya Bhaskar; Rao Mahendra; Puri Raj K; Kawasaki Ernest S
Comparisons between transcriptional regulation and RNA expression in human embryonic stem cell lines.
Stem cells and development 2006;15(3):315-23.
2006: Kioi Mitomu; Husain Syed R; Croteau David; Kunwar Sandeep; Puri Raj K
Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapy.
Technology in cancer research & treatment 2006;5(3):239-50.
2006: Kawakami Koji; Terabe Masaki; Kawakami Mariko; Berzofsky Jay A; Puri Raj K
Characterization of a novel human tumor antigen interleukin-13 receptor alpha2 chain.
Cancer research 2006;66(8):4434-42.
2006: Han Jing; Farnsworth Richard L; Tiwari Jawahar L; Tian Jie; Lee Hin; Ikonomi Pranvera; Byrnes Andrew P; Goodman Jesse L; Puri Raj K
Quality prediction of cell substrate using gene expression profiling.
Genomics 2006;87(4):552-9.
2006: Joshi Bharat H; Hogaboam Cory; Dover Pamela; Husain Syed R; Puri Raj K
Role of interleukin-13 in cancer, pulmonary fibrosis, and other T(H)2-type diseases.
Vitamins and hormones 2006;74():479-504.
2006: Luo Yongquan; Bhattacharya Bhaskar; Yang Amy X; Puri Raj K; Rao Mahendra S
Designing, testing, and validating a microarray for stem cell characterization.
Methods in molecular biology (Clifton, N.J.) 2006;331():241-66.
2006: Kunwar Sandeep; Chang Susan M; Prados Michael D; Berger Mitchel S; Sampson John H; Croteau David; Sherman Jeffrey W; Grahn Amy Y; Shu Vince S; Dul Jeanne L; Husain Syed R; Joshi Bharat H; Pedain Christoph; Puri Raj K
Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies.
Neurosurgical focus 2006;20(4):E15.
2006: Shimamura Takeshi; Husain Syed R; Puri Raj K
The IL-4 and IL-13 pseudomonas exotoxins: new hope for brain tumor therapy.
Neurosurgical focus 2006;20(4):E11.
2005: Kioi Mitomu; Takahashi Satoru; Kawakami Mariko; Kawakami Koji; Kreitman Robert J; Puri Raj K
Expression and targeting of interleukin-4 receptor for primary and advanced ovarian cancer therapy.
Cancer research 2005;65(18):8388-96.
2005: Kawakami Koji; Kawakami Mariko; Liu Qi; Puri Raj K
Combined effects of radiation and interleukin-13 receptor-targeted cytotoxin on glioblastoma cell lines.
International journal of radiation oncology, biology, physics 2005;63(1):230-7.
2005: Han Jing; Lee Hin; Nguyen Nga Yen; Beaucage Serge L; Puri Raj K
Novel multiple 5'-amino-modified primer for DNA microarrays.
Genomics 2005;86(2):252-8.
2005: Yang Amy X; Mejido Josef; Luo Yongquan; Zeng Xianmin; Schwartz Catherine; Wu Tianxia; Thies R Scott; Bhattacharya Bhaskar; Han Jing; Freed Bill; Rao Mahendra; Puri Raj K
Development of a focused microarray to assess human embryonic stem cell differentiation.
Stem cells and development 2005;14(3):270-84.
2005: Kawakami Koji; Kioi Mitomu; Liu Qi; Kawakami Mariko; Puri Raj K
Evidence that IL-13R alpha2 chain in human glioma cells is responsible for the antitumor activity mediated by receptor-directed cytotoxin therapy.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2005;28(3):193-202.
2005: Kawakami Mariko; Kawakami Koji; Kioi Mitomu; Leland Pamela; Puri Raj K
Hodgkin lymphoma therapy with interleukin-4 receptor-directed cytotoxin in an infiltrating animal model.
Blood 2005;105(9):3707-13.
2005: Gonzalez-Moreno Oscar; Calvo Alfonso; Joshi Bharat H; Abasolo Ibane; Leland Pamela; Wang Zhou; Montuenga Luis; Puri Raj K; Green Jeffrey E
Gene expression profiling identifies IL-13 receptor alpha 2 chain as a therapeutic target in prostate tumor cells overexpressing adrenomedullin.
International journal of cancer. Journal international du cancer 2005;114(6):870-8.
2005: Parney Ian F; Kunwar Sandeep; McDermott Michael; Berger Mitchel; Prados Michael; Cha Soonmee; Croteau David; Puri Raj K; Chang Susan M
Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma.
Journal of neurosurgery 2005;102(2):267-75.
2005: Joshi Bharat H; Puri Raj K
Optimization of expression and purification of two biologically active chimeric fusion proteins that consist of human interleukin-13 and Pseudomonas exotoxin in Escherichia coli.
Protein expression and purification 2005;39(2):189-98.
2005: Bhattacharya Bhaskar; Cai Jingli; Luo Youngquan; Miura Takumi; Mejido Josef; Brimble Sandii N; Zeng Xianmin; Schulz Thomas C; Rao Mahendra S; Puri Raj K
Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies.
BMC developmental biology 2005;5():22.
2004: Kawakami Koji; Kawakami Mariko; Kioi Mitomu; Husain Syed R; Puri Raj K
Distribution kinetics of targeted cytotoxin in glioma by bolus or convection-enhanced delivery in a murine model.
Journal of neurosurgery 2004;101(6):1004-11.
2004: Kioi Mitomu; Kawakami Koji; Puri Raj K
Analysis of antitumor activity of an interleukin-13 (IL-13) receptor-targeted cytotoxin composed of IL-13 antagonist and Pseudomonas exotoxin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 1):6231-8.
2004: Kawakami Mariko; Kawakami Koji; Takahashi Satoru; Abe Masato; Puri Raj K
Analysis of interleukin-13 receptor alpha2 expression in human pediatric brain tumors.
Cancer 2004;101(5):1036-42.
2004: Kawakami Koji; Kawakami Mariko; Puri Raj K
Nitric oxide accelerates interleukin-13 cytotoxin-mediated regression in head and neck cancer animal model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):5264-70.
2004: Beseth Bryce D; Cameron Robert B; Leland Pamela; You Liang; Varricchio Frederick; Kreitman Robert J; Maki Richard A; Jablons David M; Husain Syed R; Puri Raj K
Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts.
The Annals of thoracic surgery 2004;78(2):436-43; discussion 436-43.
2004: Jakubzick Claudia; Choi Esther S; Carpenter Kristin J; Kunkel Steven L; Evanoff Holly; Martinez Fernando J; Flaherty Kevin R; Toews Galen B; Colby Thomas V; Travis William D; Joshi Bharat H; Puri Raj K; Hogaboam Cory M
Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia.
The American journal of pathology 2004;164(6):1989-2001.
2004: Kioi Mitomu; Kawakami Koji; Puri Raj K
Mechanism of action of interleukin-13 antagonist (IL-13E13K) in cells expressing various types of IL-4R.
Cellular immunology 2004;229(1):41-51.
2004: Jakubzick C; Choi E S; Kunkel S L; Evanoff H; Martinez F J; Puri R K; Flaherty K R; Toews G B; Colby T V; Kazerooni E A; Gross B H; Travis W D; Hogaboam C M
Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia.
Journal of clinical pathology 2004;57(5):477-86.
2004: Bhattacharya Bhaskar; Miura Takumi; Brandenberger Ralph; Mejido Josef; Luo Yongquan; Yang Amy X; Joshi Bharat H; Ginis Irene; Thies R Scott; Amit Michal; Lyons Ian; Condie Brian G; Itskovitz-Eldor Joseph; Rao Mahendra S; Puri Raj K
Gene expression in human embryonic stem cell lines: unique molecular signature.
Blood 2004;103(8):2956-64.
2004: Kawakami Koji; Kawakami Mariko; Puri Raj K
Specifically targeted killing of interleukin-13 (IL-13) receptor-expressing breast cancer by IL-13 fusion cytotoxin in animal model of human disease.
Molecular cancer therapeutics 2004;3(2):137-47.
2004: Jakubzick Claudia; Kunkel Steven L; Puri Raj K; Hogaboam Cory M
Therapeutic targeting of IL-4- and IL-13-responsive cells in pulmonary fibrosis.
Immunologic research 2004;30(3):339-49.
2004: Zeng Xianmin; Miura Takumi; Luo Yongquan; Bhattacharya Bhaskar; Condie Brian; Chen Jia; Ginis Irene; Lyons Ian; Mejido Josef; Puri Raj K; Rao Mahendra S; Freed William J
Properties of pluripotent human embryonic stem cells BG01 and BG02.
Stem cells (Dayton, Ohio) 2004;22(3):292-312.
2003: Ishii Ken J; Kawakami Koji; Gursel Ihsan; Conover Jacqueline; Joshi Bharat H; Klinman Dennis M; Puri Raj K
Antitumor therapy with bacterial DNA and toxin: complete regression of established tumor induced by liposomal CpG oligodeoxynucleotides plus interleukin-13 cytotoxin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6516-22.
2003: Kawakami Mariko; Kawakami Koji; Kasperbauer Jan L; Hinkley Lucinda L; Tsukuda Mamoru; Strome Scott E; Puri Raj K
Interleukin-13 receptor alpha2 chain in human head and neck cancer serves as a unique diagnostic marker.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6381-8.
2003: Husain Syed R; Puri Raj K
Interleukin-13 receptor-directed cytotoxin for malignant glioma therapy: from bench to bedside.
Journal of neuro-oncology 2003;65(1):37-48.
2003: Kawakami Mariko; Kawakami Koji; Puri Raj K
Interleukin-4-Pseudomonas exotoxin chimeric fusion protein for malignant glioma therapy.
Journal of neuro-oncology 2003;65(1):15-25.
2003: de Jong Mariska C; Scheffer George L; Broxterman Henk J; Hooijberg Jan H; Slootstra Jerry W; Meloen Rob H; Kreitman Robert J; Husain Syed R; Joshi Bharat H; Puri Raj K; Scheper Rik J
Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):5009-17.
2003: Jakubzick Claudia; Choi Esther S; Joshi Bharat H; Keane Michael P; Kunkel Steven L; Puri Raj K; Hogaboam Cory M
Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4- and IL-13-responsive cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(5):2684-93.
2003: Joshi Bharat H; Leland Pamela; Puri Raj K
Identification and characterization of interleukin-13 receptor in human medulloblastoma and targeting these receptors with interleukin-13-pseudomonas exotoxin fusion protein.
Croatian medical journal 2003;44(4):455-62.
2003: Kawakami K; Kawakami M; Husain S R; Puri R K
Potent antitumor activity of IL-13 cytotoxin in human pancreatic tumors engineered to express IL-13 receptor alpha2 chain in vivo.
Gene therapy 2003;10(13):1116-28.
2003: Kawakami Koji; Kawakami Mariko; Husain Syed R; Puri Raj K
Effect of interleukin (IL)-4 cytotoxin on breast tumor growth after in vivo gene transfer of IL-4 receptor alpha chain.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1826-36.
2003: Jakubzick Claudia; Choi Esther S; Kunkel Steven L; Joshi Bharat H; Puri Raj K; Hogaboam Cory M
Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts.
The American journal of pathology 2003;162(5):1475-86.
2003: Husain Syed R; Kawakami Koji; Kawakami Mariko; Puri Raj K
Interleukin-4 receptor-targeted cytotoxin therapy of androgen-dependent and -independent prostate carcinoma in xenograft models.
Molecular cancer therapeutics 2003;2(3):245-54.
2003: Kawakami Mariko; Kawakami Koji; Puri Raj K
Tumor regression mechanisms by IL-13 receptor-targeted cancer therapy involve apoptotic pathways.
International journal of cancer. Journal international du cancer 2003;103(1):45-52.
2002: Kawakami Koji; Kawakami Mariko; Puri Raj K
IL-13 receptor-targeted cytotoxin cancer therapy leads to complete eradication of tumors with the aid of phagocytic cells in nude mice model of human cancer.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):7119-26.
2002: Petricoin Emanuel F; Hackett Joseph L; Lesko Lawrence J; Puri Raj K; Gutman Steven I; Chumakov Konstantin; Woodcock Janet; Feigal David W; Zoon Kathryn C; Sistare Frank D
Medical applications of microarray technologies: a regulatory science perspective.
Nature genetics 2002;32 Suppl():474-9.
2002: Kawakami Mariko; Kawakami Koji; Stepensky Vitaly A; Maki Richard A; Robin Howard; Muller Wayne; Husain Syed R; Puri Raj K
Interleukin 4 receptor on human lung cancer: a molecular target for cytotoxin therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3503-11.
2002: Kawakami Mariko; Kawakami Koji; Puri Raj K
Intratumor administration of interleukin 13 receptor-targeted cytotoxin induces apoptotic cell death in human malignant glioma tumor xenografts.
Molecular cancer therapeutics 2002;1(12):999-1007.
2002: Jakubzick Claudia; Kunkel Steven L; Joshi Bharat H; Puri Raj K; Hogaboam Cory M
Interleukin-13 fusion cytotoxin arrests Schistosoma mansoni egg-induced pulmonary granuloma formation in mice.
The American journal of pathology 2002;161(4):1283-97.
2002: Kawakami Koji; Husain Syed R; Kawakami Mariko; Puri Raj K
Improved anti-tumor activity and safety of interleukin-13 receptor targeted cytotoxin by systemic continuous administration in head and neck cancer xenograft model.
Molecular medicine (Cambridge, Mass.) 2002;8(8):487-94.
2002: Kawakami Koji; Kawakami Mariko; Puri Raj K
Cytokine receptor as a sensitizer for targeted cancer therapy.
Anti-cancer drugs 2002;13(7):693-9.
2002: Kawakami Koji; Kawakami Mariko; Husain Syed R; Puri Raj K
Targeting interleukin-4 receptors for effective pancreatic cancer therapy.
Cancer research 2002;62(13):3575-80.
2002: Joshi Bharat H; Kawakami Koji; Leland Pamela; Puri Raj K
Heterogeneity in interleukin-13 receptor expression and subunit structure in squamous cell carcinoma of head and neck: differential sensitivity to chimeric fusion proteins comprised of interleukin-13 and a mutated form of Pseudomonas exotoxin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(6):1948-56.
2002: Kawakami Mariko; Kawakami Koji; Puri Raj K
Apoptotic pathways of cell death induced by an interleukin-13 receptor-targeted recombinant cytotoxin in head and neck cancer cells.
Cancer immunology, immunotherapy : CII 2002;50(12):691-700.
2002: Blease Kate; Schuh Jane M; Jakubzick Claudia; Lukacs Nicholas W; Kunkel Steven L; Joshi Bharat H; Puri Raj K; Kaplan Mark H; Hogaboam Cory M
Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma.
The American journal of pathology 2002;160(2):481-90.
2002: Joshi B H; Leland P; Silber J; Kreitman R J; Pastan I; Berger M; Puri R K
IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein.
British journal of cancer 2002;86(2):285-91.
2002: Kawakami Koji; Kawakami Mariko; Leland Pamela; Puri Raj K
Internalization property of interleukin-4 receptor alpha chain increases cytotoxic effect of interleukin-4 receptor-targeted cytotoxin in cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):258-66.
2001: Kawakami K; Kawakami M; Snoy P J; Husain S R; Puri R K
In vivo overexpression of IL-13 receptor alpha2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice.
The Journal of experimental medicine 2001;194(12):1743-54.
2001: Blease K; Jakubzick C; Schuh J M; Joshi B H; Puri R K; Hogaboam C M
IL-13 fusion cytotoxin ameliorates chronic fungal-induced allergic airway disease in mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6583-92.
2001: Kawakami K; Husain S R; Bright R K; Puri R K
Gene transfer of interleukin 13 receptor alpha2 chain dramatically enhances the antitumor effect of IL-13 receptor-targeted cytotoxin in human prostate cancer xenografts.
Cancer gene therapy 2001;8(11):861-8.
2001: Joshi B H; Leland P; Asher A; Prayson R A; Varricchio F; Puri R K
In situ expression of interleukin-4 (IL-4) receptors in human brain tumors and cytotoxicity of a recombinant IL-4 cytotoxin in primary glioblastoma cell cultures.
Cancer research 2001;61(22):8058-61.
2001: Kawakami K; Kawakami M; Joshi B H; Puri R K
Interleukin-13 receptor-targeted cancer therapy in an immunodeficient animal model of human head and neck cancer.
Cancer research 2001;61(16):6194-200.
2001: Kawakami K; Takeshita F; Puri R K
Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain.
The Journal of biological chemistry 2001;276(27):25114-20.
2001: Oshima Y; Puri R K
A novel interleukin 13 (IL-13) antagonist that blocks the biological activity of human IL-13 in immune and nonimmune cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(8):1469-71.
2001: Kawakami K; Taguchi J; Murata T; Puri R K
The interleukin-13 receptor alpha2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway.
Blood 2001;97(9):2673-9.
2001: Oshima Y; Puri R K
Characterization of a powerful high affinity antagonist that inhibits biological activities of human interleukin-13.
The Journal of biological chemistry 2001;276(18):15185-91.
2001: Husain S R; Joshi B H; Puri R K
Interleukin-13 receptor as a unique target for anti-glioblastoma therapy.
International journal of cancer. Journal international du cancer 2001;92(2):168-75.
2001: Kawakami M; Leland P; Kawakami K; Puri R K
Mutation and functional analysis of IL-13 receptors in human malignant glioma cells.
Oncology research 2001;12(11-12):459-67.
2001: Kawakami K; Kawakami M; Puri R K
Overexpressed cell surface interleukin-4 receptor molecules can be successfully targeted for antitumor cytotoxin therapy.
Critical reviews in immunology 2001;21(1-3):299-310.
2001: Puri R K
Cytotoxins directed at interleukin-4 receptors as therapy for human brain tumors.
Methods in molecular biology (Clifton, N.J.) 2001;166():155-76.
2000: Joshi B H; Husain S R; Puri R K
Preclinical studies with IL-13PE38QQR for therapy of malignant glioma.
Drug news & perspectives 2000;13(10):599-605.
2000: Puri R K
IL-4 receptor-directed cytotoxin for therapy of AIDS-associated KS tumors.
Drug news & perspectives 2000;13(7):395-402.
2000: Kawakami K; Joshi B H; Puri R K
Sensitization of cancer cells to interleukin 13-pseudomonas exotoxin-induced cell death by gene transfer of interleukin 13 receptor alpha chain.
Human gene therapy 2000;11(13):1829-35.
2000: Kawakami K; Leland P; Puri R K
Structure, function, and targeting of interleukin 4 receptors on human head and neck cancer cells.
Cancer research 2000;60(11):2981-7.
2000: Husain S R; Puri R K
Interleukin-13 fusion cytotoxin as a potent targeted agent for AIDS-Kaposi's sarcoma xenograft.
Blood 2000;95(11):3506-13.
2000: Oshima Y; Joshi B H; Puri R K
Conversion of interleukin-13 into a high affinity agonist by a single amino acid substitution.
The Journal of biological chemistry 2000;275(19):14375-80.
2000: Leland P; Taguchi J; Husain S R; Kreitman R J; Pastan I; Puri R K
Human breast carcinoma cells express type II IL-4 receptors and are sensitive to antitumor activity of a chimeric IL-4-Pseudomonas exotoxin fusion protein in vitro and in vivo.
Molecular medicine (Cambridge, Mass.) 2000;6(3):165-78.
2000: Joshi B H; Plautz G E; Puri R K
Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas.
Cancer research 2000;60(5):1168-72.
1999: Husain S R; Kreitman R J; Pastan I; Puri R K
Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model.
Nature medicine 1999;5(7):817-22.
1999: Puri R K
Development of a recombinant interleukin-4-Pseudomonas exotoxin for therapy of glioblastoma.
Toxicologic pathology 1999;27(1):53-7.
1998: Murata T; Husain S R; Mohri H; Puri R K
Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathway.
International immunology 1998;10(8):1103-10.
1998: Husain S R; Behari N; Kreitman R J; Pastan I; Puri R K
Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy.
Cancer research 1998;58(16):3649-53.
1998: Debinski W; Gibo D M; Obiri N I; Kealiher A; Puri R K
Novel anti-brain tumor cytotoxins specific for cancer cells.
Nature biotechnology 1998;16(5):449-53.
1998: Debinski W; Gibo D M; Puri R K
Novel way to increase targeting specificity to a human glioblastoma-associated receptor for interleukin 13.
International journal of cancer. Journal international du cancer 1998;76(4):547-51.
1998: Murata T; Taguchi J; Puri R K
Interleukin-13 receptor alpha' but not alpha chain: a functional component of interleukin-4 receptors.
Blood 1998;91(10):3884-91.
1998: Mehrotra R; Varricchio F; Husain S R; Puri R K
Head and neck cancers, but not benign lesions, express interleukin-4 receptors in situ.
Oncology reports 1998;5(1):45-8.
1997: Hillman G G; Younes E; Visscher D; Hamzavi F; Kim S; Lam J S; Montecillo E J; Ali E; Pontes J E; Puri R K; Haas G P
Inhibition of murine renal carcinoma pulmonary metastases by systemic administration of interferon gamma: mechanism of action and potential for combination with interleukin 4.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(10):1799-806.
1997: Murata T; Obiri N I; Debinski W; Puri R K
Structure of IL-13 receptor: analysis of subunit composition in cancer and immune cells.
Biochemical and biophysical research communications 1997;238(1):90-4.
1997: Maini A; Hillman G; Haas G P; Wang C Y; Montecillo E; Hamzavi F; Pontes J E; Leland P; Pastan I; Debinski W; Puri R K
Interleukin-13 receptors on human prostate carcinoma cell lines represent a novel target for a chimeric protein composed of IL-13 and a mutated form of Pseudomonas exotoxin.
The Journal of urology 1997;158(3 Pt 1):948-53.
1997: Dhawan S; Puri R K; Kumar A; Duplan H; Masson J M; Aggarwal B B
Human immunodeficiency virus-1-tat protein induces the cell surface expression of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in human endothelial cells.
Blood 1997;90(4):1535-44.
1997: Obiri N I; Murata T; Debinski W; Puri R K
Modulation of interleukin (IL)-13 binding and signaling by the gammac chain of the IL-2 receptor.
The Journal of biological chemistry 1997;272(32):20251-8.
1997: Husain S R; Gill P; Kreitman R J; Pastan I; Puri R K
Interleukin-4 receptor expression on AIDS-associated Kaposi's sarcoma cells and their targeting by a chimeric protein comprised of circularly permuted interleukin-4 and Pseudomonas exotoxin.
Molecular medicine (Cambridge, Mass.) 1997;3(5):327-38.
1997: Husain S R; Obiri N I; Gill P; Zheng T; Pastan I; Debinski W; Puri R K
Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(2):151-6.
1997: Murata T; Puri R K
Comparison of IL-13- and IL-4-induced signaling in EBV-immortalized human B cells.
Cellular immunology 1997;175(1):33-40.
1997: Murata T; Obiri N I; Puri R K
Human ovarian-carcinoma cell lines express IL-4 and IL-13 receptors: comparison between IL-4- and IL-13-induced signal transduction.
International journal of cancer. Journal international du cancer 1997;70(2):230-40.
1997: Obiri N I; Leland P; Murata T; Debinski W; Puri R K
The IL-13 receptor structure differs on various cell types and may share more than one component with IL-4 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):756-64.
1997: Varricchio F; Husain S R; Leland P; Gill P; Puri R K
Interleukin-4 receptor expression in vivo on human AIDS-related Kaposi's sarcoma.
Oncology research 1997;9(9):495-503.
1996: Puri R K; Hoon D S; Leland P; Snoy P; Rand R W; Pastan I; Kreitman R J
Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma.
Cancer research 1996;56(24):5631-7.
1996: Obiri N I; Husain S R; Debinski W; Puri R K
Interleukin 13 inhibits growth of human renal cell carcinoma cells independently of the p140 interleukin 4 receptor chain.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(10):1743-9.
1996: Husain S R; Leland P; Aggarwal B B; Puri R K
Transcriptional up-regulation of interleukin 4 receptors by human immunodeficiency virus type 1 tat gene.
AIDS research and human retroviruses 1996;12(14):1349-59.
1996: Debinski W; Miner R; Leland P; Obiri N I; Puri R K
Receptor for interleukin (IL) 13 does not interact with IL4 but receptor for IL4 interacts with IL13 on human glioma cells.
The Journal of biological chemistry 1996;271(37):22428-33.
1996: Puri R K; Leland P; Obiri N I; Husain S R; Mule J; Pastan I; Kreitman R J
An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity.
Cellular immunology 1996;171(1):80-6.
1996: Puri R K; Leland P; Obiri N I; Husain S R; Kreitman R J; Haas G P; Pastan I; Debinski W
Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR).
Blood 1996;87(10):4333-9.
1996: Murata T; Noguchi P D; Puri R K
IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):2972-8.
1995: Murata T; Noguchi P D; Puri R K
Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells.
The Journal of biological chemistry 1995;270(51):30829-36.
1995: Debinski W; Obiri N I; Powers S K; Pastan I; Puri R K
Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(11):1253-8.
1995: Kreitman R J; Puri R K; Pastan I
Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma.
Cancer research 1995;55(15):3357-63.
1995: Debinski W; Obiri N I; Pastan I; Puri R K
A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4.
The Journal of biological chemistry 1995;270(28):16775-80.
1995: Obiri N I; Tandon N; Puri R K
Up-regulation of intercellular adhesion molecule 1 (ICAM-1) on human renal cell carcinoma cells by interleukin-4.
International journal of cancer. Journal international du cancer 1995;61(5):635-42.
1995: Obiri N I; Debinski W; Leonard W J; Puri R K
Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15.
The Journal of biological chemistry 1995;270(15):8797-804.
1995: Younes E; Haas G P; Visscher D; Pontes J E; Puri R K; Hillman G G
Intralesional treatment of established murine primary renal tumor with interleukin-4: localized effect on primary tumor with no impact on metastases.
The Journal of urology 1995;153(2):490-3.
1995: Hillman G G; Younes E; Visscher D; Ali E; Lam J S; Montecillo E; Pontes J E; Haas G P; Puri R K
Systemic treatment with interleukin-4 induces regression of pulmonary metastases in a murine renal cell carcinoma model.
Cellular immunology 1995;160(2):257-63.
1995: Puri R K; Leland P; Aggarwal B B
Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line.
AIDS research and human retroviruses 1995;11(1):31-40.
1995: Puri R K
Structure and function of interleukin-4 and its receptor.
Cancer treatment and research 1995;80():143-85.
1995: Leland P; Obiri N; Aggarwal B B; Puri R K
Suramin blocks binding of interleukin-4 to its receptors on human tumor cells and interleukin-4-induced mitogenic response.
Oncology research 1995;7(5):227-35.
1994: Kreitman R J; Puri R K; Leland P; Lee B; Pastan I
Site-specific conjugation to interleukin 4 containing mutated cysteine residues produces interleukin 4-toxin conjugates with improved binding and activity.
Biochemistry 1994;33(38):11637-44.
1994: Puri R K; Leland P; Kreitman R J; Pastan I
Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein.
International journal of cancer. Journal international du cancer 1994;58(4):574-81.
1994: Kreitman R J; Puri R K; Pastan I
A circularly permuted recombinant interleukin 4 toxin with increased activity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):6889-93.
1994: Hillman G G; Puri R K; Kukuruga M A; Pontes J E; Haas G P
Growth and major histocompatibility antigen expression regulation by IL-4, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) on human renal cell carcinoma.
Clinical and experimental immunology 1994;96(3):476-83.
1994: Puri R K; Mehrotra P T; Leland P; Kreitman R J; Siegel J P; Pastan I
A chimeric protein comprised of IL-4 and Pseudomonas exotoxin is cytotoxic for activated human lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3693-700.
1994: Puri R K; Debinski W; Obiri N; Kreitman R; Pastan I
Human renal cell carcinoma cells are sensitive to the cytotoxic effect of a chimeric protein composed of human interleukin-4 and Pseudomonas exotoxin.
Cellular immunology 1994;154(1):369-79.
1994: Obiri N I; Siegel J P; Varricchio F; Puri R K
Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells.
Clinical and experimental immunology 1994;95(1):148-55.
1994: Obiri N I; Puri R K
Characterization of interleukin-4 receptors expressed on human renal cell carcinoma cells.
Oncology research 1994;6(9):419-27.
1993: Puri R K; Leland P
Tumor necrosis factor upregulates interleukin-4 receptors on murine sarcoma cells.
Biochemical and biophysical research communications 1993;197(3):1424-30.
1993: Varricchio F; Obiri N I; Haas G P; Puri R K
Immunostaining of interleukin-4 receptor on human renal cell carcinoma.
Lymphokine and cytokine research 1993;12(6):465-9.
1993: Debinski W; Puri R K; Kreitman R J; Pastan I
A wide range of human cancers express interleukin 4 (IL4) receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin.
The Journal of biological chemistry 1993;268(19):14065-70.
1993: Obiri N I; Hillman G G; Haas G P; Sud S; Puri R K
Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin-4.
The Journal of clinical investigation 1993;91(1):88-93.
1993: Puri R K; Siegel J P
Interleukin-4 and cancer therapy.
Cancer investigation 1993;11(4):473-86.
1992: Puri R K; FitzGerald D; Leland P; Kozak R W; Pastan I
In vitro and in vivo suppression of interleukin-2-activated killer cell activity by chimeric proteins between interleukin-2 and Pseudomonas exotoxin.
Cellular immunology 1992;143(2):324-34.
1992: Puri R K; Aggarwal B B
Human immunodeficiency virus type 1 tat gene up-regulates interleukin 4 receptors on a human B-lymphoblastoid cell line.
Cancer research 1992;52(13):3787-90.
1992: Ansher S S; Puri R K; Thompson W C; Habig W H
The effects of interleukin 2 and alpha-interferon administration on hepatic drug metabolism in mice.
Cancer research 1992;52(2):262-6.
1991: Puri R K; Ogata M; Leland P; Feldman G M; FitzGerald D; Pastan I
Expression of high-affinity interleukin 4 receptors on murine sarcoma cells and receptor-mediated cytotoxicity of tumor cells to chimeric protein between interleukin 4 and Pseudomonas exotoxin.
Cancer research 1991;51(11):3011-7.
1991: Wong R A; Alexander R B; Puri R K; Rosenberg S A
In vivo proliferation of adoptively transferred tumor-infiltrating lymphocytes in mice.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1991;10(2):120-30.
1991: Puri R K; Leland P; Razzaque A
Antigen(s)-specific tumour-infiltrating lymphocytes from tumour induced by human herpes virus-6 (HHV-6) DNA transfected NIH 3T3 transformants.
Clinical and experimental immunology 1991;83(1):96-101.
1990: Kozak R W; Lorberboum-Galski H; Jones L; Puri R K; Willingham M C; Malek T; Fitzgerald D J; Waldmann T A; Pastan I
IL-2-PE40 prevents the development of tumors in mice injected with IL-2 receptor expressing EL4 transfectant tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(8):2766-71.
1990: Puri R K; Travis W D; Rosenberg S A
In vivo administration of interferon alpha and interleukin 2 induces proliferation of lymphoid cells in the organs of mice.
Cancer research 1990;50(17):5543-50.
1990: Puri R K; Finbloom D S; Leland P; Mostowski H; Siegel J P
Expression of high-affinity IL-4 receptors on murine tumour infiltrating lymphocytes and their up-regulation by IL-2.
Immunology 1990;70(4):492-7.
1989: Puri R K; Travis W D; Rosenberg S A
Decrease in interleukin 2-induced vascular leakage in the lungs of mice by administration of recombinant interleukin 1 alpha in vivo.
Cancer research 1989;49(4):969-76.
1989: Puri R K; Rosenberg S A
Combined effects of interferon alpha and interleukin 2 on the induction of a vascular leak syndrome in mice.
Cancer immunology, immunotherapy : CII 1989;28(4):267-74.

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