Atul Purohit

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Foster Paul A; Ho Yaik T; Newman Simon P; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul
STX140 and STX641 cause apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.
Day Joanna M; Tutill Helena J; Foster Paul A; Bailey Helen V; Heaton Wesley B; Sharland Christopher M; Vicker Nigel; Potter Barry V L; Purohit Atul; Reed Michael J
Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.
Vicker Nigel; Sharland Christopher M; Heaton Wesley B; Gonzalez Ana M Ramos; Bailey Helen V; Smith Andrew; Springall Jeremy S; Day Joanna M; Tutill Helena J; Reed Michael J; Purohit Atul; Potter Barry V L
The design of novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors.

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2009: Foster Paul A; Ho Yaik T; Newman Simon P; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul
STX140 and STX641 cause apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.
Anticancer research 2009;29(10):3751-7.
2009: Day Joanna M; Tutill Helena J; Foster Paul A; Bailey Helen V; Heaton Wesley B; Sharland Christopher M; Vicker Nigel; Potter Barry V L; Purohit Atul; Reed Michael J
Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.
Molecular and cellular endocrinology 2009;301(1-2):251-8.
2009: Vicker Nigel; Sharland Christopher M; Heaton Wesley B; Gonzalez Ana M Ramos; Bailey Helen V; Smith Andrew; Springall Jeremy S; Day Joanna M; Tutill Helena J; Reed Michael J; Purohit Atul; Potter Barry V L
The design of novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors.
Molecular and cellular endocrinology 2009;301(1-2):259-65.
2009: Day Joanna M; Purohit Atul; Tutill Helena J; Foster Paul A; Woo L W Lawrence; Potter Barry V L; Reed Michael J
The development of steroid sulfatase inhibitors for hormone-dependent cancer therapy.
Annals of the New York Academy of Sciences 2009;1155():80-7.
2009: Day J M; Foster P A; Tutill H J; Newman S P; Ho Y T; Leese M P; Potter B V L; Reed M J; Purohit A
BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure.
British journal of cancer 2009;100(3):476-86.
2008: Jourdan Fabrice; Bubert Christian; Leese Mathew P; Smith Andrew; Ferrandis Eric; Regis-Lydi Sandra; Newman Simon P; Purohit Atul; Reed Michael J; Potter Barry V L
Effects of C-17 heterocyclic substituents on the anticancer activity of 2-ethylestra-1,3,5(10)-triene-3-O-sulfamates: synthesis, in vitro evaluation and computational modelling.
Organic & biomolecular chemistry 2008;6(22):4108-19.
2008: Parsons M F C; Foster P A; Chander S K; Jhalli R; Newman S P; Leese M P; Potter B V L; Purohit A; Reed M J
The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer.
British journal of cancer 2008;99(9):1433-41.
2008: Bubert Christian; Woo L W Lawrence; Sutcliffe Oliver B; Mahon Mary F; Chander Surinder K; Purohit Atul; Reed Michael J; Potter Barry V L
Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino)benzonitrile: SAR, crystal structures, in vitro and in vivo activities.
ChemMedChem 2008;3(11):1708-30.
2008: Foster Paul A; Reed Michael J; Purohit Atul
Recent developments of steroid sulfatase inhibitors as anti-cancer agents.
Anti-cancer agents in medicinal chemistry 2008;8(7):732-8.
2008: Day Joanna M; Tutill Helena J; Purohit Atul; Reed Michael J
Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis.
Endocrine-related cancer 2008;15(3):665-92.
2008: Foster Paul A; Ho Yaik T; Newman Simon P; Kasprzyk Philip G; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul
2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique.
Breast cancer research and treatment 2008;111(2):251-60.
2008: Foster Paul A; Chander Surinder K; Parsons Michael F C; Newman Simon P; Woo L W Lawrence; Potter Barry V L; Reed Michael J; Purohit Atul
Efficacy of three potent steroid sulfatase inhibitors: pre-clinical investigations for their use in the treatment of hormone-dependent breast cancer.
Breast cancer research and treatment 2008;111(1):129-38.
2008: Woo L W Lawrence; Fischer Delphine S; Sharland Christopher M; Trusselle Melanie; Foster Paul A; Chander Surinder K; Di Fiore Anna; Supuran Claudiu T; De Simone Giuseppina; Purohit Atul; Reed Michael J; Potter Barry V L
Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography.
Molecular cancer therapeutics 2008;7(8):2435-44.
2008: Foster Paul A; Woo L W Lawrence; Potter Barry V L; Reed Michael J; Purohit Atul
The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer.
Endocrinology 2008;149(8):4035-42.
2008: Wood Paul M; Woo L W Lawrence; Labrosse Jean-Robert; Trusselle Melanie N; Abbate Sergio; Longhi Giovanna; Castiglioni Ettore; Lebon France; Purohit Atul; Reed Michael J; Potter Barry V L
Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.
Journal of medicinal chemistry 2008;51(14):4226-38.
2008: Purohit A; Chander S K; Woo L W L; Parsons M F C; Jhalli R; Potter B V L; Reed M J
Inhibition of steroid sulphatase activity via the percutaneous route: a new option for breast cancer therapy.
Anticancer research 2008;28(3A):1517-23.
2008: Foster Paul A; Stengel C; Ali Tauhid; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul; Newman Simon P
A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140.
Anticancer research 2008;28(3A):1483-91.
2008: Day Joanna M; Foster Paul A; Tutill Helena J; Parsons Michael F C; Newman Simon P; Chander Surinder K; Allan Gillian M; Lawrence Harshani R; Vicker Nigel; Potter Barry V L; Reed Michael J; Purohit Atul
17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer.
International journal of cancer. Journal international du cancer 2008;122(9):1931-40.
2008: Allan Gillian M; Vicker Nigel; Lawrence Harshani R; Tutill Helena J; Day Joanna M; Huchet Marion; Ferrandis Eric; Reed Michael J; Purohit Atul; Potter Barry V L
Novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1: templates for design.
Bioorganic & medicinal chemistry 2008;16(8):4438-56.
2008: Jackson Toby; Woo L W Lawrence; Trusselle Melanie N; Purohit Atul; Reed Michael J; Potter Barry V L
Non-steroidal aromatase inhibitors based on a biphenyl scaffold: synthesis, in vitro SAR, and molecular modelling.
ChemMedChem 2008;3(4):603-18.
2008: Foster Paul A; Newman Simon P; Leese Mathew P; Bernetiere Sonia; Diolez Christian; Camara Jose; Hacher Beatrice; Baronnet Marie-Madeleine; Ali Tauhid; Potter Barry V L; Reed Michael J; Purohit Atul
A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer.
Anticancer research 2008;28(2A):577-81.
2008: Leese Mathew P; Jourdan Fabrice L; Gaukroger Keira; Mahon Mary F; Newman Simon P; Foster Paul A; Stengel Chloe; Regis-Lydi Sandra; Ferrandis Eric; Di Fiore Anna; De Simone Giuseppina; Supuran Claudiu T; Purohit Atul; Reed Michael J; Potter Barry V L
Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.
Journal of medicinal chemistry 2008;51(5):1295-308.
2008: Stengel Chloe; Newman Simon P; Day Joanna M; Tutill Helena J; Reed Michael J; Purohit Atul
Effects of mutations and glycosylations on STS activity: a site-directed mutagenesis study.
Molecular and cellular endocrinology 2008;283(1-2):76-82.
2008: Newman Simon P; Foster Paul A; Stengel Chloe; Day Joanna M; Ho Yaik T; Judde Jean-Gabriel; Lassalle Myriam; Prevost Gregoire; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul
STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):597-606.
2007: Newman S P; Foster P A; Ho Y T; Day J M; Raobaikady B; Kasprzyk P G; Leese M P; Potter B V L; Reed M J; Purohit A
The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers.
British journal of cancer 2007;97(12):1673-82.
2007: Jackson Toby; Woo L W Lawrence; Trusselle Melanie N; Chander Surinder K; Purohit Atul; Reed Michael J; Potter Barry V L
Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity.
Organic & biomolecular chemistry 2007;5(20):2940-52.
2007: Jackson Toby; Woo L W Lawrence; Trusselle Melanie N; Chander Surinder K; Purohit Atul; Reed Michael J; Potter Barry V L
Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity.
Organic & biomolecular chemistry 2007;5(18):2940-52.
2007: Bubert Christian; Leese Mathew P; Mahon Mary F; Ferrandis Eric; Regis-Lydi Sandra; Kasprzyk Philip G; Newman Simon P; Ho Yaik T; Purohit Atul; Reed Michael J; Potter Barry V L
3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity.
Journal of medicinal chemistry 2007;50(18):4431-43.
2007: Stanway S J; Purohit A; Reed M J
Measurement of estrone sulfate in postmenopausal women: comparison of direct RIA and GC-MS/MS methods for monitoring response to endocrine therapy in women with breast cancer.
Anticancer research 2007;27(4C):2765-7.
2007: Woo L W Lawrence; Bubert Christian; Sutcliffe Oliver B; Smith Andrew; Chander Surinder K; Mahon Mary F; Purohit Atul; Reed Michael J; Potter Barry V L
Dual aromatase-steroid sulfatase inhibitors.
Journal of medicinal chemistry 2007;50(15):3540-60.
2007: Su Xiangdong; Vicker Nigel; Lawrence Harshani; Smith Andrew; Purohit Atul; Reed Michael J; Potter Barry V L
Inhibition of human and rat 11beta-hydroxysteroid dehydrogenase type 1 by 18beta-glycyrrhetinic acid derivatives.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):312-20.
2007: Vicker Nigel; Su Xiangdong; Ganeshapillai Dharshini; Smith Andrew; Purohit Atul; Reed Michael J; Potter Barry V L
Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):123-9.
2007: Parish David C; Ghilchik Margaret W; Day Joanna M; Eaton James; Purohit Atul; Reed Michael J
Cytokines in human breast cyst fluid.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):241-5.
2007: Raobaikady B; Parsons M F C; Reed M J; Purohit A
Tibolone and its delta-4, 7alpha-methyl norethisterone metabolite are reversible inhibitors of human aromatase.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):154-60.
2007: Chander S K; Foster P A; Leese M P; Newman S P; Potter B V L; Purohit A; Reed M J
In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol.
British journal of cancer 2007;96(9):1368-76.
2007: Stanway Susannah J; Delavault Patrick; Purohit Atul; Woo L W Lawrence; Thurieau Christophe; Potter Barry V L; Reed Michael J
Steroid sulfatase: a new target for the endocrine therapy of breast cancer.
The oncologist 2007;12(4):370-4.
2006: Leese Mathew P; Leblond Bertrand; Smith Andrew; Newman Simon P; Di Fiore Anna; De Simone Giuseppina; Supuran Claudiu T; Purohit Atul; Reed Michael J; Potter Barry V L
2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity.
Journal of medicinal chemistry 2006;49(26):7683-96.
2006: Foster Paul A; Newman Simon P; Chander Surinder K; Stengel Chloe; Jhalli Roma; Woo Lawrence L W; Potter Barry V L; Reed Michael J; Purohit Atul
In vivo efficacy of STX213, a second-generation steroid sulfatase inhibitor, for hormone-dependent breast cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5543-9.
2006: Raobaikady Bindumalini; Parsons Michael F C; Reed Michael J; Purohit Atul
Lack of aromatisation of the 3-keto-4-ene metabolite of tibolone to an estrogenic derivative.
Steroids 2006;71(7):639-46.
2006: Vicker Nigel; Lawrence Harshani R; Allan Gillian M; Bubert Christian; Smith Andrew; Tutill Helena J; Purohit Atul; Day Joanna M; Mahon Mary F; Reed Michael J; Potter Barry V L
Focused libraries of 16-substituted estrone derivatives and modified e-ring steroids: inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
ChemMedChem 2006;1(4):464-81.
2006: Stanway Susannah J; Purohit Atul; Woo L W Lawrence; Sufi Saulat; Vigushin David; Ward Rebecca; Wilson Richard H; Stanczyk Frank Z; Dobbs Nicola; Kulinskaya Elena; Elliott Moira; Potter Barry V L; Reed Michael J; Coombes R Charles
Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(5):1585-92.
2006: Day Joanna M; Tutill Helena J; Newman Simon P; Purohit Atul; Lawrence Harshani R; Vicker Nigel; Potter Barry V L; Reed Michael J
17Beta-hydroxysteroid dehydrogenase Type 1 and Type 2: association between mRNA expression and activity in cell lines.
Molecular and cellular endocrinology 2006;248(1-2):246-9.
2006: Purohit A; Tutill H J; Day J M; Chander S K; Lawrence H R; Allan G M; Fischer D S; Vicker N; Newman S P; Potter B V L; Reed M J
The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer.
Molecular and cellular endocrinology 2006;248(1-2):199-203.
2006: Allan Gillian M; Bubert Christian; Vicker Nigel; Smith Andrew; Tutill Helena J; Purohit Atul; Reed Michael J; Potter Barry V L
Novel, potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Molecular and cellular endocrinology 2006;248(1-2):204-7.
2006: Su Xiangdong; Vicker Nigel; Ganeshapillai Dharshini; Smith Andrew; Purohit Atul; Reed Michael J; Potter Barry V L
Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
Molecular and cellular endocrinology 2006;248(1-2):214-7.
2006: Allan Gillian M; Lawrence Harshani R; Cornet Josephine; Bubert Christian; Fischer Delphine S; Vicker Nigel; Smith Andrew; Tutill Helena J; Purohit Atul; Day Joanna M; Mahon Mary F; Reed Michael J; Potter Barry V L
Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Journal of medicinal chemistry 2006;49(4):1325-45.
2006: Newman Simon P; Ireson Christopher R; Tutill Helena J; Day Joanna M; Parsons Michael F C; Leese Mathew P; Potter Barry V L; Reed Michael J; Purohit Atul
The role of 17beta-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells.
Cancer research 2006;66(1):324-30.
2005: Raobaikady Bindumalini; Reed Michael J; Leese Mathew P; Potter Barry V L; Purohit Atul
Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono- and bis-3-O-sulphamates.
International journal of cancer. Journal international du cancer 2005;117(1):150-9.
2005: Fischer Delphine S; Allan Gillian M; Bubert Christian; Vicker Nigel; Smith Andrew; Tutill Helena J; Purohit Atul; Wood Lynn; Packham Graham; Mahon Mary F; Reed Michael J; Potter Barry V L
E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Journal of medicinal chemistry 2005;48(18):5749-70.
2005: Leese Mathew P; Hejaz Hatem A M; Mahon Mary F; Newman Simon P; Purohit Atul; Reed Michael J; Potter Barry V L
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
Journal of medicinal chemistry 2005;48(16):5243-56.
2005: Lloyd Matthew D; Thiyagarajan Nethaji; Ho Yaik T; Woo L W Lawrence; Sutcliffe Oliver B; Purohit Atul; Reed Michael J; Acharya K Ravi; Potter Barry V L
First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.
Biochemistry 2005;44(18):6858-66.
2005: Lawrence Harshani R; Vicker Nigel; Allan Gillian M; Smith Andrew; Mahon Mary F; Tutill Helena J; Purohit Atul; Reed Michael J; Potter Barry V L
Novel and potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Journal of medicinal chemistry 2005;48(8):2759-62.
2005: Reed M J; Purohit A; Woo L W L; Newman S P; Potter B V L
Steroid sulfatase: molecular biology, regulation, and inhibition.
Endocrine reviews 2005;26(2):171-202.
2005: Leese Mathew P; Leblond Bertrand; Newman Simon P; Purohit Atul; Reed Michael J; Potter Barry V L
Anti-cancer activities of novel D-ring modified 2-substituted estrogen-3-O-sulfamates.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):239-51.
2005: Raobaikady B; Day J M; Purohit A; Potter B V L; Reed M J
The nature of inhibition of steroid sulphatase activity by tibolone and its metabolites.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):229-37.
2005: Utsumi T; Leese M P; Chander S K; Gaukroger K; Purohit A; Newman S P; Potter B V L; Reed M J
The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):219-27.
2005: Purohit A; Ghilchik M W; Leese M P; Potter B V L; Reed M J
Regulation of aromatase activity by cytokines, PGE2 and 2-methoxyoestrone-3-O-sulphamate in fibroblasts derived from normal and malignant breast tissues.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):167-72.
2005: Wood Paul M; Woo L W Lawrence; Humphreys Anna; Chander Surinder K; Purohit Atul; Reed Michael J; Potter Barry V L
A letrozole-based dual aromatase-sulphatase inhibitor with in vivo activity.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):123-30.
2005: Lloyd Matthew D; Pederick Richard L; Natesh Ramanathan; Woo L W Lawrence; Purohit Atul; Reed Michael J; Acharya K Ravi; Potter Barry V L
Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent.
The Biochemical journal 2005;385(Pt 3):715-20.
2004: Ireson C R; Chander S K; Purohit A; Parish D C; Woo L W L; Potter B V L; Reed M J
Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats.
British journal of cancer 2004;91(7):1399-404.
2004: Chander Surinder K; Purohit Atul; Woo L W Lawrence; Potter Barry V L; Reed Michael J
The role of steroid sulphatase in regulating the oestrogenicity of oestrogen sulphamates.
Biochemical and biophysical research communications 2004;322(1):217-22.
2004: Su Xiangdong; Lawrence Harshani; Ganeshapillai Dharshini; Cruttenden Adrian; Purohit Atul; Reed Michael J; Vicker Nigel; Potter Barry V L
Novel 18beta-glycyrrhetinic acid analogues as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenases.
Bioorganic & medicinal chemistry 2004;12(16):4439-57.
2004: Vicker Nigel; Su Xiangdong; Lawrence Harshani; Cruttenden Adrian; Purohit Atul; Reed Michael J; Potter Barry V L
A novel 18 beta-glycyrrhetinic acid analogue as a potent and selective inhibitor of 11 beta-hydroxysteroid dehydrogenase 2.
Bioorganic & medicinal chemistry letters 2004;14(12):3263-7.
2004: Leese Mathew P; Newman Simon P; Purohit Atul; Reed Michael J; Potter Barry V L
2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents.
Bioorganic & medicinal chemistry letters 2004;14(12):3135-8.
2004: Hejaz Hatem A M; Woo L W Lawrence; Purohit Atul; Reed Michael J; Potter Barry V L
Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase.
Bioorganic & medicinal chemistry 2004;12(10):2759-72.
2004: Reed Julie E; Woo L W Lawrence; Robinson James J; Leblond Bertrand; Leese Mathew P; Purohit Atul; Reed Michael J; Potter Barry V L
2-difluoromethyloestrone 3-O-sulphamate, a highly potent steroid sulphatase inhibitor.
Biochemical and biophysical research communications 2004;317(1):169-75.
2004: Newman Simon P; Leese Mathew P; Purohit Atul; James David R C; Rennie Catherine E; Potter Barry V L; Reed Michael J
Inhibition of in vitro angiogenesis by 2-methoxy- and 2-ethyl-estrogen sulfamates.
International journal of cancer. Journal international du cancer 2004;109(4):533-40.
2004: Ireson C R; Chander S K; Purohit A; Perera S; Newman S P; Parish D; Leese M P; Smith A C; Potter B V L; Reed M J
Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents.
British journal of cancer 2004;90(4):932-7.
2003: Glennon Richard A; Daoud Maha Khalifa; Dukat Malgorzata; Teitler Milt; Herrick-Davis Katharine; Purohit Anil; Syed Hasan
Arylguanidine and arylbiguanide binding at 5-HT3 serotonin receptors: a QSAR study.
Bioorganic & medicinal chemistry 2003;11(20):4449-54.
2003: Purohit A; Woo L W L; Chander S K; Newman S P; Ireson C; Ho Y; Grasso A; Leese M P; Potter B V L; Reed M J
Steroid sulphatase inhibitors for breast cancer therapy.
The Journal of steroid biochemistry and molecular biology 2003;86(3-5):423-32.
2003: Ho Y T; Newman S P; Purohit A; Leese M P; Potter B V L; Reed M J
The effects of 2-methoxy oestrogens and their sulphamoylated derivatives in conjunction with TNF-alpha on endothelial and fibroblast cell growth, morphology and apoptosis.
The Journal of steroid biochemistry and molecular biology 2003;86(2):189-96.
2003: Khorana Nantaka; Smith Carol; Herrick-Davis Kathy; Purohit Anil; Teitler Milt; Grella Brian; Dukat Malgorzata; Glennon Richard A
Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.
Journal of medicinal chemistry 2003;46(18):3930-7.
2003: Woo L W Lawrence; Sutcliffe Oliver B; Bubert Christian; Grasso Anna; Chander Surinder K; Purohit Atul; Reed Michael J; Potter Barry V L
First dual aromatase-steroid sulfatase inhibitors.
Journal of medicinal chemistry 2003;46(15):3193-6.
2003: Ho Y T; Purohit A; Vicker N; Newman S P; Robinson J J; Leese M P; Ganeshapillai D; Woo L W L; Potter B V L; Reed M J
Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates.
Biochemical and biophysical research communications 2003;305(4):909-14.
2003: Fischer Delphine S; Woo L W Lawrence; Mahon Mary F; Purohit Atul; Reed Michael J; Potter Barry V L
D-ring modified estrone derivatives as novel potent inhibitors of steroid sulfatase.
Bioorganic & medicinal chemistry 2003;11(8):1685-700.
2003: Rahman Ashraf A; Daoud Maha Khalifa; Dukat Malgorzata; Herrick-Davis Katharine; Purohit Anil; Teitler Milt; do Amaral Antonia Taveres; Malvezzi Alberto; Glennon Richard A
Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG).
Bioorganic & medicinal chemistry letters 2003;13(6):1119-23.
2003: Vicker Nigel; Ho Yaikat; Robinson James; Woo Lawrence L W; Purohit Atul; Reed Michael J; Potter Barry V L
Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II.
Bioorganic & medicinal chemistry letters 2003;13(5):863-5.
2003: Khorana Nantaka; Purohit Anil; Herrick-Davis Katherine; Teitler Milt; Glennon Richard A
gamma-Carbolines: binding at 5-HT5A serotonin receptors.
Bioorganic & medicinal chemistry 2003;11(5):717-22.
2003: Raobaikady Bindumalini; Purohit Atul; Chander Surinder K; Woo L W Lawrence; Leese Mathew P; Potter Barry V L; Reed Michael J
Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):351-8.
2003: Fischer Delphine S; Chander Surinder K; Woo L W Lawrence; Fenton Janine C; Purohit Atul; Reed Michael J; Potter Barry V L
Novel D-ring modified steroid derivatives as potent, non-estrogenic, steroid sulfatase inhibitors with in vivo activity.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):343-9.
2003: Ireson Christopher R; Parish David; Purohit Atul; Woo Lawrence W L; Potter Barry V L; Chander Surinder K; Reed Michael J
Development of a sensitive high-performance liquid chromatography method for the detection of 667 COUMATE in vivo.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):337-42.
2003: Day Joanna M; Newman Simon P; Comninos Alexander; Solomon Claire; Purohit Atul; Leese Matthew P; Potter Barry V L; Reed Michael J
The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):317-25.
2003: Suzuki R N; Newman S P; Purohit A; Leese M P; Potter B V L; Reed M J
Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):269-78.
2003: Purohit A; Singh A; Ghilchik M W; Serlupi-Crescenzi O; Reed M J
Inhibition of IL-6+IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts.
British journal of cancer 2003;88(4):630-5.
2002: Howarth Nicola M; Purohit Atul; Robinson James J; Vicker Nigel; Reed Michael J; Potter Barry V L
Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity: homology model construction and docking studies.
Biochemistry 2002;41(50):14801-14.
2002: Purohit Atul; Reed Michael J
Regulation of estrogen synthesis in postmenopausal women.
Steroids 2002;67(12):979-83.
2002: Purohit A; Malini B; Hooymans C; Newman S P
Inhibition of oestrone sulphatase activity by tibolone and its metabolites.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(1):1-6.
2002: Purohit Atul; Newman Simon P; Reed Michael J
The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer.
Breast cancer research : BCR 2002;4(2):65-9.
2001: Parish D; Purohit A; Singh A; Rosankiewicz J; Ghilchik M W; Reed M J
Peptide inhibition of cytokine-stimulated aromatase activity in breast tissue fibroblasts.
The Journal of steroid biochemistry and molecular biology 2001;79(1-5):165-72.
2001: Reed M J; Purohit A
Aromatase regulation and breast cancer.
Clinical endocrinology 2001;54(5):563-71.
2001: Budai B; Számel I; Sulyok Z; Német M; Bak M; Ottó S; Reed M J; Purohit A; Parish D C; Kralovánszky J
Characteristics of cystic breast disease with special regard to breast cancer development.
Anticancer research 2001;21(1B):749-52.
2001: Purohit A; Woo L W; Barrow D; Hejaz H A; Nicholson R I; Potter B V; Reed M J
Non-steroidal and steroidal sulfamates: new drugs for cancer therapy.
Molecular and cellular endocrinology 2001;171(1-2):129-35.
2000: Newman S P; Purohit A; Ghilchik M W; Potter B V; Reed M J
Regulation of steroid sulphatase expression and activity in breast cancer.
The Journal of steroid biochemistry and molecular biology 2000;75(4-5):259-64.
2000: Malini B; Purohit A; Ganeshapillai D; Woo L W; Potter B V; Reed M J
Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates.
The Journal of steroid biochemistry and molecular biology 2000;75(4-5):253-8.
2000: Bonser J; Walker J; Purohit A; Reed M J; Potter B V; Willis D S; Franks S; Mason H D
Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production.
The Journal of endocrinology 2000;167(3):465-71.
2000: MacCarthy-Morrogh L; Townsend P A; Purohit A; Hejaz HAM; Potter BVL; Reed M J; Packham G
Differential effects of estrone and estrone-3-O-sulfamate derivatives on mitotic. Arrest, apoptosis, and microtubule assembly in human breast cancer cells.
Cancer research 2000;60(19):5441-50.
2000: Woo L L; Purohit A; Malini B; Reed M J; Potter B V
Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates.
Chemistry & biology 2000;7(10):773-91.
2000: Budai B; Számel I; Sulyok Z; Németh M; Bak M; Kralovánszky J; Ottó S; Besznyák I; Purohit A; Parish D C; Reed M J
Influence of hormonal status of patients with cystic disease on the composition of cyst fluid and breast cancer risk.
Anticancer research 2000;20(5C):3879-86.
2000: Purohit A; Woo L W; Potter B V; Reed M J
In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE.
Cancer research 2000;60(13):3394-6.
2000: Singh A; Purohit A; Hejaz H A; Potter B V; Reed M J
Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate.
Molecular and cellular endocrinology 2000;160(1-2):61-6.
2000: Purohit A; Hejaz H A; Walden L; MacCarthy-Morrogh L; Packham G; Potter B V; Reed M J
The effect of 2-methoxyoestrone-3-O-sulphamate on the growth of breast cancer cells and induced mammary tumours.
International journal of cancer. Journal international du cancer 2000;85(4):584-9.
2000: Purohit A; Budai B; Wang D Y; Willemsen E L; de Winkel A; Parish D; Ghilchik M W; Szamel I; Reed M J
Modulation of oestrone sulphate formation and hydrolysis in breast cancer cells by breast cyst fluid from British and Hungarian women.
British journal of cancer 2000;82(2):492-6.
1999: Hejaz H A; Purohit A; Mahon M F; Reed M J; Potter B V
Synthesis and biological activity of the superestrogen (E)-17-oximino-3-O-sulfamoyl-1,3,5(10)-estratriene: x-ray crystal structure of (E)-17-oximino-3-hydroxy-1,3,5(10)-estratriene.
Journal of medicinal chemistry 1999;42(16):3188-92.
1999: Purohit A; Singh A; Ghilchik M W; Reed M J
Inhibition of tumor necrosis factor alpha-stimulated aromatase activity by microtubule-stabilizing agents, paclitaxel and 2-methoxyestradiol.
Biochemical and biophysical research communications 1999;261(1):214-7.
1999: Singh A; Purohit A; Ghilchik M W; Reed M J
The regulation of aromatase activity in breast fibroblasts: the role of interleukin-6 and prostaglandin E2.
Endocrine-related cancer 1999;6(2):139-47.
1999: Purohit A; Hejaz H A; Woo L W; van Strien A E; Potter B V; Reed M J
Recent advances in the development of steroid sulphatase inhibitors.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):227-38.
1999: Purohit A; de Giovani C V; Reed M J
The regulation of oestrone sulphate formation in breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1999;68(3-4):129-35.
1999: Purohit A; Singh A; Reed M J
Regulation of steroid sulphatase and oestradiol 17 beta-hydroxysteroid dehydrogenase in breast cancer.
Biochemical Society transactions 1999;27(2):323-7.
1998: Purohit A; Vernon K A; Hummelinck A E; Woo L W; Hejaz H A; Potter B V; Reed M J
The development of A-ring modified analogues of oestrone-3-O-sulphamate as potent steroid sulphatase inhibitors with reduced oestrogenicity.
The Journal of steroid biochemistry and molecular biology 1998;64(5-6):269-75.
1998: Woo L W; Howarth N M; Purohit A; Hejaz H A; Reed M J; Potter B V
Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase.
Journal of medicinal chemistry 1998;41(7):1068-83.
1998: Purohit A; Potter B V; Parker M G; Reed M J
Steroid sulphatase: expression, isolation and inhibition for active-site identification studies.
Chemico-biological interactions 1998;109(1-3):183-93.
1998: Singh A; Purohit A; Coldham N G; Ghilchik M W; Reed M J
Biochemical control of breast aromatase.
Breast cancer research and treatment 1998;49 Suppl 1():S9-14; discussion S33-7.
1997: Reed M J; Purohit A
Breast cancer and the role of cytokines in regulating estrogen synthesis: an emerging hypothesis.
Endocrine reviews 1997;18(5):701-15.
1997: Purohit A; Froome V A; Wang D Y; Potter B V; Reed M J
Measurement of oestrone sulphatase activity in white blood cells to monitor in vivo inhibition of steroid sulphatase activity by oestrone-3-O-sulphamate.
The Journal of steroid biochemistry and molecular biology 1997;62(1):45-51.
1997: Singh A; Purohit A; Duncan L J; Mokbel K; Ghilchik M W; Reed M J
Control of aromatase activity in breast tumours: the role of the immune system.
The Journal of steroid biochemistry and molecular biology 1997;61(3-6):185-92.
1997: Howarth N M; Purohit A; Reed M J; Potter B V
Estrone sulfonates as inhibitors of estrone sulfatase.
Steroids 1997;62(4):346-50.
1996: Purohit A; Woo L W; Singh A; Winterborn C J; Potter B V; Reed M J
In vivo activity of 4-methylcoumarin-7-O-sulfamate, a nonsteroidal, nonestrogenic steroid sulfatase inhibitor.
Cancer research 1996;56(21):4950-5.
1996: Purohit A; Wang D Y; Ghilchik M W; Reed M J
Regulation of aromatase and sulphatase in breast tumour cells.
The Journal of endocrinology 1996;150 Suppl():S65-71.
1996: Hidalgo Aragones M I; Purohit A; Parish D; Sahm U G; Pouton C W; Potter B V; Reed M J
Pharmacokinetics of oestrone-3-O-sulphamate.
The Journal of steroid biochemistry and molecular biology 1996;58(5-6):611-7.
1996: Purohit A; Reed M J; Morris N C; Williams G J; Potter B V
Regulation and inhibition of steroid sulfatase activity in breast cancer.
Annals of the New York Academy of Sciences 1996;784():40-9.
1996: Woo L W; Purohit A; Reed M J; Potter B V
Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates.
Journal of medicinal chemistry 1996;39(7):1349-51.
1996: Woo L W; Lightowler M; Purohit A; Reed M J; Potter B V
Heteroatom-substituted analogues of the active-site directed inhibitor estra-1,3,5(10)-trien-17-one-3-sulphamate inhibit estrone sulphatase by a different mechanism.
The Journal of steroid biochemistry and molecular biology 1996;57(1-2):79-88.
1995: Singh A; Purohit A; Wang D Y; Duncan L J; Ghilchik M W; Reed M J
IL-6sR: release from MCF-7 breast cancer cells and role in regulating peripheral oestrogen synthesis.
The Journal of endocrinology 1995;147(2):R9-12.
1995: Purohit A; Ghilchik M W; Duncan L; Wang D Y; Singh A; Walker M M; Reed M J
Aromatase activity and interleukin-6 production by normal and malignant breast tissues.
The Journal of clinical endocrinology and metabolism 1995;80(10):3052-8.
1995: Purohit A; Williams G J; Roberts C J; Potter B V; Reed M J
In vivo inhibition of oestrone sulphatase and dehydroepiandrosterone sulphatase by oestrone-3-O-sulphamate.
International journal of cancer. Journal international du cancer 1995;63(1):106-11.
1995: Purohit A; Williams G J; Howarth N M; Potter B V; Reed M J
Inactivation of steroid sulfatase by an active site-directed inhibitor, estrone-3-O-sulfamate.
Biochemistry 1995;34(36):11508-14.
1995: Chapman O; Purohit A; Wang D Y; Ghilchik M W; Reed M J
Oestrone sulphatase activity in normal and malignant breast tissues: relationship with tumour location.
Anticancer research 1995;15(4):1467-71.
1995: Reed M J; Purohit A; Duncan L J; Singh A; Roberts C J; Williams G J; Potter B V
The role of cytokines and sulphatase inhibitors in regulating oestrogen synthesis in breast tumours.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):413-20.
1994: Macdiarmid F; Wang D; Duncan L J; Purohit A; Ghilchick M W; Reed M J
Stimulation of aromatase activity in breast fibroblasts by tumor necrosis factor alpha.
Molecular and cellular endocrinology 1994;106(1-2):17-21.
1994: Purohit A; Dauvois S; Parker M G; Potter B V; Williams G J; Reed M J
The hydrolysis of oestrone sulphate and dehydroepiandrosterone sulphate by human steroid sulphatase expressed in transfected COS-1 cells.
The Journal of steroid biochemistry and molecular biology 1994;50(1-2):101-4.
1994: Purohit A; Howarth N M; Potter B V; Reed M J
Inhibition of steroid sulphatase activity by steroidal methylthiophosphonates: potential therapeutic agents in breast cancer.
The Journal of steroid biochemistry and molecular biology 1994;48(5-6):523-7.
1994: Howarth N M; Purohit A; Reed M J; Potter B V
Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential.
Journal of medicinal chemistry 1994;37(2):219-21.
1993: Reed M J; Topping L; Coldham N G; Purohit A; Ghilchik M W; James V H
Control of aromatase activity in breast cancer cells: the role of cytokines and growth factors.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):589-96.
1993: Duncan L; Purohit A; Howarth N M; Potter B V; Reed M J
Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer.
Cancer research 1993;53(2):298-303.
1992: Purohit A; Riaz A A; Ghilchik M W; Reed M J
The origin of oestrone sulphate in normal and malignant breast tissues in postmenopausal women.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1992;24(11):532-6.
1992: Williams D A; Purohit A; Reed M J
Immunochemical specificity of placental NADPH cytochrome c (P-450) reductase in neoplastic and non-neoplastic human tissue.
The Journal of steroid biochemistry and molecular biology 1992;43(6):515-22.
1992: Purohit A; Flanagan A M; Reed M J
Estrogen synthesis by osteoblast cell lines.
Endocrinology 1992;131(4):2027-9.
1992: James V H; Reed M J; Purohit A
Inhibition of oestrogen synthesis in postmenopausal women with breast cancer.
The Journal of steroid biochemistry and molecular biology 1992;43(1-3):149-53.
1992: Purohit A; Reed M J
Oestrogen sulphatase activity in hormone-dependent and hormone-independent breast-cancer cells: modulation by steroidal and non-steroidal therapeutic agents.
International journal of cancer. Journal international du cancer 1992;50(6):901-5.
1992: Purohit A; Chapman O; Duncan L; Reed M J
Modulation of oestrone sulphatase activity in breast cancer cell lines by growth factors.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):563-6.
1991: Reed M J; Singh A; Ghilchik M W; Coldham N G; Purohit A
Regulation of oestradiol 17 beta hydroxysteroid dehydrogenase in breast tissues: the role of growth factors.
The Journal of steroid biochemistry and molecular biology 1991;39(5B):791-8.
1990: Reed M J; Lai L C; Owen A M; Singh A; Coldham N G; Purohit A; Ghilchik M W; Shaikh N A; James V H
Effect of treatment with 4-hydroxyandrostenedione on the peripheral conversion of androstenedione to estrone and in vitro tumor aromatase activity in postmenopausal women with breast cancer.
Cancer research 1990;50(1):193-6.
1989: Purohit A; Lai L C; Singh A; Coldham N G; Ghilchik M W; Reed M J; James V H
The effect of medroxyprogesterone acetate on aromatase and DNA polymerase alpha activities in breast tumours.
Journal of steroid biochemistry 1989;34(1-6):443-6.

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