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Atul Purohit

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L W Lawrence Woo; Paul M Wood; Christian Bubert; Atul Purohit; Mark P Thomas; Barry V L Potter
Synthesis and Structure-Activity Relationship Studies of Derivatives of the Dual Aromatase-Sulfatase Inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate.
Joanna M Day; Paul A Foster; Jonathan D Hargrave; Barry V L Potter; Michael J Reed; Fabien Schmidlin; christopher sharland; Helena Tutill; Nigel Vicker; Atul Purohit
STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model.
L W Lawrence Woo; Bertrand Leblond; Atul Purohit; Barry V L Potter
Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors.

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2013: L W Lawrence Woo; Paul M Wood; Christian Bubert; Atul Purohit; Mark P Thomas; Barry V L Potter
Synthesis and Structure-Activity Relationship Studies of Derivatives of the Dual Aromatase-Sulfatase Inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate.
ChemMedChem 2013;8(5):779-99.
2013: Joanna M Day; Paul A Foster; Jonathan D Hargrave; Barry V L Potter; Michael J Reed; Fabien Schmidlin; christopher sharland; Helena Tutill; Nigel Vicker; Atul Purohit
STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model.
Endocrine-related cancer 2013;20(1):53-64.
2012: L W Lawrence Woo; Bertrand Leblond; Atul Purohit; Barry V L Potter
Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors.
Bioorganic & medicinal chemistry 2012;20(8):2506-19.
2011: L W Lawrence Woo; Atul Purohit; Oliver B Sutcliffe; Mark P Thomas; Dharshini Ganeshapillai; Mary F Mahon; Bindu Malini; Barry V L Potter
Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495).
ChemMedChem 2011;6(11):2019-34.
2011: Paul M Wood; Mary F Mahon; Atul Purohit; Mark P Thomas; L W Lawrence Woo; Barry V L Potter
Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates.
ChemMedChem 2011;6(8):1423-38.
2011: Fabrice Jourdan; Mathew P Leese; Simon P Newman; Surinder Chander; Wolfgang Dohle; Eric Ferrandis; Atul Purohit; Barry V L Potter
Structure-activity relationships of C-17-substituted estratriene-3-O-sulfamates as anticancer agents.
Journal of medicinal chemistry 2011;54(13):4863-79.
2011: L W Lawrence Woo; Atul Purohit; Barry V L Potter
Development of steroid sulfatase inhibitors.
Molecular and cellular endocrinology 2011;340(2):175-85.
2010: Paul M Wood; L W Lawrence Woo; Jean-Robert Labrosse; Mark P Thomas; Mary F Mahon; Surinder K Chander; Atul Purohit; Michael J Reed; Barry V L Potter
Bicyclic derivatives of the potent dual aromatase-steroid sulfatase inhibitor 2-bromo-4-{[(4-cyanophenyl)(4h-1,2,4-triazol-4-yl)amino]methyl}phenylsulfamate: synthesis, SAR, crystal structure, and in vitro and in vivo activities.
ChemMedChem 2010;5(9):1577-93.
2010: J M Day; Helena Tutill; Atul Purohit
17ß-hydroxysteroid dehydrogenase inhibitors.
Minerva endocrinologica 2010;35(2):87-108.
2010: Mathew P Leese; Fabrice Jourdan; Meriel R Kimberley; Gyles E Cozier; Nethaji Thiyagarajan; Chloe Stengel; Sandra Regis-Lydi; Paul A Foster; Simon P Newman; K Ravi Acharya; Eric Ferrandis; Atul Purohit; Michael J Reed; Barry V L Potter
Chimeric microtubule disruptors.
Chemical communications (Cambridge, England) 2010;46(17):2907-9.
2010: Fabrice Jourdan; Mathew P Leese; Wolfgang Dohle; Ernest Hamel; Eric Ferrandis; Simon P Newman; Atul Purohit; Michael J Reed; Barry V L Potter
Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.
Journal of medicinal chemistry 2010;53(7):2942-51.
2010: L W Lawrence Woo; Toby Jackson; Aurélien Putey; Gyles Cozier; Philip Leonard; K Ravi Acharya; Surinder K Chander; Atul Purohit; Michael J Reed; Barry V L Potter
Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.
Journal of medicinal chemistry 2010;53(5):2155-70.
2010: C Stengel; Simon P Newman; M P Leese; B V L Potter; Michael J Reed; Atul Purohit
Class III beta-tubulin expression and in vitro resistance to microtubule targeting agents.
British journal of cancer 2010;102(2):316-24.
2009: Paul A Foster; Yaik T Ho; Simon P Newman; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit
STX140 and STX641 cause apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.
Anticancer research 2009;29(10):3751-7.
2009: Joanna M Day; Helena Tutill; Paul A Foster; Helen V Bailey; Wesley B Heaton; christopher sharland; Nigel Vicker; Barry V L Potter; Atul Purohit; Michael J Reed
Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.
Molecular and cellular endocrinology 2009;301(1-2):251-8.
2009: Nigel Vicker; christopher sharland; Wesley B Heaton; Ana M Ramos Gonzalez; Helen V Bailey; Andrew Smith; Jeremy S Springall; Joanna M Day; Helena Tutill; Michael J Reed; Atul Purohit; Barry V L Potter
The design of novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors.
Molecular and cellular endocrinology 2009;301(1-2):259-65.
2009: J M Day; Paul A Foster; Helena Tutill; Simon P Newman; Y T Ho; M P Leese; Barry V L Potter; Michael J Reed; Atul Purohit
BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure.
British journal of cancer 2009;100(3):476-86.
2009: Joanna M Day; Atul Purohit; Helena Tutill; Paul A Foster; L W Lawrence Woo; Barry V L Potter; Michael J Reed
The development of steroid sulfatase inhibitors for hormone-dependent cancer therapy.
Annals of the New York Academy of Sciences 2009;1155():80-7.
2008: Fabrice Jourdan; Christian Bubert; Mathew P Leese; Andrew Smith; Eric Ferrandis; Sandra Regis-Lydi; Simon P Newman; Atul Purohit; Michael J Reed; Barry V L Potter
Effects of C-17 heterocyclic substituents on the anticancer activity of 2-ethylestra-1,3,5(10)-triene-3-O-sulfamates: synthesis, in vitro evaluation and computational modelling.
Organic & biomolecular chemistry 2008;6(22):4108-19.
2008: M F C Parsons; Paul A Foster; Surinder K Chander; R Jhalli; Simon P Newman; Mathew P Leese; Barry V L Potter; Atul Purohit; Michael J Reed
The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer.
British journal of cancer 2008;99(9):1433-41.
2008: Christian Bubert; L W Lawrence Woo; Oliver B Sutcliffe; Mary F Mahon; Surinder K Chander; Atul Purohit; Michael J Reed; Barry V L Potter
Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino)benzonitrile: SAR, crystal structures, in vitro and in vivo activities.
ChemMedChem 2008;3(11):1708-30.
2008: Paul A Foster; Michael J Reed; Atul Purohit
Recent developments of steroid sulfatase inhibitors as anti-cancer agents.
Anti-cancer agents in medicinal chemistry 2008;8(7):732-8.
2008: Joanna M Day; Helena Tutill; Atul Purohit; Michael J Reed
Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis.
Endocrine-related cancer 2008;15(3):665-92.
2008: Paul A Foster; Yaik T Ho; Simon P Newman; Philip G Kasprzyk; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit
2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique.
Breast cancer research and treatment 2008;111(2):251-60.
2008: Paul A Foster; Surinder K Chander; Michael F C Parsons; Simon P Newman; L W Lawrence Woo; Barry V L Potter; Michael J Reed; Atul Purohit
Efficacy of three potent steroid sulfatase inhibitors: pre-clinical investigations for their use in the treatment of hormone-dependent breast cancer.
Breast cancer research and treatment 2008;111(1):129-38.
2008: L W Lawrence Woo; Delphine S Fischer; christopher sharland; Melanie N Trusselle; Paul A Foster; Surinder K Chander; Anna Di Fiore; Claudiu T Supuran; Giuseppina De simone; Atul Purohit; Michael J Reed; Barry V L Potter
Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography.
Molecular cancer therapeutics 2008;7(8):2435-44.
2008: Paul A Foster; L W Lawrence Woo; Barry V L Potter; Michael J Reed; Atul Purohit
The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer.
Endocrinology 2008;149(8):4035-42.
2008: Paul M Wood; L W Lawrence Woo; Jean-Robert Labrosse; Melanie N Trusselle; Sergio Abbate; Giovanna Longhi; Ettore Castiglioni; France Lebon; Atul Purohit; Michael J Reed; Barry V L Potter
Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.
Journal of medicinal chemistry 2008;51(14):4226-38.
2008: Atul Purohit; Surinder K Chander; L W Lawrence Woo; M F C Parsons; R Jhalli; Barry V L Potter; Michael J Reed
Inhibition of steroid sulphatase activity via the percutaneous route: a new option for breast cancer therapy.
Anticancer research 2008;28(3A):1517-23.
2008: Paul A Foster; C Stengel; Tauhid Ali; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit; Simon P Newman
A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140.
Anticancer research 2008;28(3A):1483-91.
2008: Joanna M Day; Paul A Foster; Helena Tutill; Michael F C Parsons; Simon P Newman; Surinder K Chander; Gillian M Allan; Harshani R Lawrence; Nigel Vicker; Barry V L Potter; Michael J Reed; Atul Purohit
17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer.
International journal of cancer. Journal international du cancer 2008;122(9):1931-40.
2008: Gillian M Allan; Nigel Vicker; Harshani R Lawrence; Helena Tutill; Joanna M Day; Marion Huchet; Eric Ferrandis; Michael J Reed; Atul Purohit; Barry V L Potter
Novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1: templates for design.
Bioorganic & medicinal chemistry 2008;16(8):4438-56.
2008: Toby Jackson; L W Lawrence Woo; Melanie N Trusselle; Atul Purohit; Michael J Reed; Barry V L Potter
Non-steroidal aromatase inhibitors based on a biphenyl scaffold: synthesis, in vitro SAR, and molecular modelling.
ChemMedChem 2008;3(4):603-18.
2008: Mathew P Leese; Fabrice L Jourdan; Keira Gaukroger; Mary F Mahon; Simon P Newman; Paul A Foster; Chloe Stengel; Sandra Regis-Lydi; Eric Ferrandis; Anna Di Fiore; Giuseppina De simone; Claudiu T Supuran; Atul Purohit; Michael J Reed; Barry V L Potter
Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.
Journal of medicinal chemistry 2008;51(5):1295-308.
2008: Paul A Foster; Simon P Newman; Mathew P Leese; Sonia Bernetiere; Christian Diolez; Jose CAMARA; Beatrice Hacher; Marie-Madeleine Baronnet; Tauhid Ali; Barry V L Potter; Michael J Reed; Atul Purohit
A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer.
Anticancer research 2008;28(2A):577-81.
2008: Chloe Stengel; Simon P Newman; Joanna M Day; Helena Tutill; Michael J Reed; Atul Purohit
Effects of mutations and glycosylations on STS activity: a site-directed mutagenesis study.
Molecular and cellular endocrinology 2008;283(1-2):76-82.
2008: Simon P Newman; Paul A Foster; Chloe Stengel; Joanna M Day; Yaik T Ho; Jean-Gabriel Judde; Myriam Lassalle; Gregoire Prevost; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit
STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):597-606.
2007: Simon P Newman; Paul A Foster; Yaik T Ho; Joanna M Day; Bindumalini Raobaikady; Philip G Kasprzyk; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit
The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers.
British journal of cancer 2007;97(12):1673-82.
2007: Toby Jackson; L W Lawrence Woo; Melanie N Trusselle; Surinder K Chander; Atul Purohit; Michael J Reed; Barry V L Potter
Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity.
Organic & biomolecular chemistry 2007;5(20):2940-52.
2007: Toby Jackson; L W Lawrence Woo; Melanie N Trusselle; Surinder K Chander; Atul Purohit; Michael J Reed; Barry V L Potter
Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity.
Organic & biomolecular chemistry 2007;5(18):2940-52.
2007: Christian Bubert; Mathew P Leese; Mary F Mahon; Eric Ferrandis; Sandra Regis-Lydi; Philip G Kasprzyk; Simon P Newman; Yaik T Ho; Atul Purohit; Michael J Reed; Barry V L Potter
3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity.
Journal of medicinal chemistry 2007;50(18):4431-43.
2007: L W Lawrence Woo; Christian Bubert; Oliver B Sutcliffe; Andrew Smith; Surinder K Chander; Mary F Mahon; Atul Purohit; Michael J Reed; Barry V L Potter
Dual aromatase-steroid sulfatase inhibitors.
Journal of medicinal chemistry 2007;50(15):3540-60.
2007: Susannah J Stanway; Atul Purohit; Michael J Reed
Measurement of estrone sulfate in postmenopausal women: comparison of direct RIA and GC-MS/MS methods for monitoring response to endocrine therapy in women with breast cancer.
Anticancer research 2007;27(4C):2765-7.
2007: Surinder K Chander; Paul A Foster; Mathew P Leese; Simon P Newman; Barry V L Potter; Atul Purohit; Michael J Reed
In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol.
British journal of cancer 2007;96(9):1368-76.
2007: Xiangdong SU; Nigel Vicker; Harshani R Lawrence; Andrew Smith; Atul Purohit; Michael J Reed; Barry V L Potter
Inhibition of human and rat 11beta-hydroxysteroid dehydrogenase type 1 by 18beta-glycyrrhetinic acid derivatives.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):312-20.
2007: Nigel Vicker; Xiangdong SU; Dharshini Ganeshapillai; Andrew Smith; Atul Purohit; Michael J Reed; Barry V L Potter
Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):123-9.
2007: David C Parish; Margaret W Ghilchik; Joanna M Day; James Eaton; Atul Purohit; Michael J Reed
Cytokines in human breast cyst fluid.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):241-5.
2007: Bindumalini Raobaikady; Michael F C Parsons; Michael J Reed; Atul Purohit
Tibolone and its delta-4, 7alpha-methyl norethisterone metabolite are reversible inhibitors of human aromatase.
The Journal of steroid biochemistry and molecular biology 2007;104(3-5):154-60.
2007: Susannah J Stanway; Patrick Delavault; Atul Purohit; L W Lawrence Woo; Christophe Thurieau; Barry V L Potter; Michael J Reed
Steroid sulfatase: a new target for the endocrine therapy of breast cancer.
The oncologist 2007;12(4):370-4.
2006: Mathew P Leese; Bertrand Leblond; Andrew Smith; Simon P Newman; Anna Di Fiore; Giuseppina De simone; Claudiu T Supuran; Atul Purohit; Michael J Reed; Barry V L Potter
2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity.
Journal of medicinal chemistry 2006;49(26):7683-96.
2006: Paul A Foster; Simon P Newman; Surinder K Chander; Chloe Stengel; Roma Jhalli; Lawrence L W Woo; Barry V L Potter; Michael J Reed; Atul Purohit
In vivo efficacy of STX213, a second-generation steroid sulfatase inhibitor, for hormone-dependent breast cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5543-9.
2006: Bindumalini Raobaikady; Michael F C Parsons; Michael J Reed; Atul Purohit
Lack of aromatisation of the 3-keto-4-ene metabolite of tibolone to an estrogenic derivative.
Steroids 2006;71(7):639-46.
2006: Nigel Vicker; Harshani R Lawrence; Gillian M Allan; Christian Bubert; Andrew Smith; Helena Tutill; Atul Purohit; Joanna M Day; Mary F Mahon; Michael J Reed; Barry V L Potter
Focused libraries of 16-substituted estrone derivatives and modified e-ring steroids: inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
ChemMedChem 2006;1(4):464-81.
2006: Joanna M Day; Helena Tutill; Simon P Newman; Atul Purohit; Harshani R Lawrence; Nigel Vicker; Barry V L Potter; Michael J Reed
17Beta-hydroxysteroid dehydrogenase Type 1 and Type 2: association between mRNA expression and activity in cell lines.
Molecular and cellular endocrinology 2006;248(1-2):246-9.
2006: Atul Purohit; Helena Tutill; Joanna M Day; Surinder K Chander; Harshani R Lawrence; Gillian M Allan; Delphine S Fischer; Nigel Vicker; Simon P Newman; Barry V L Potter; Michael J Reed
The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer.
Molecular and cellular endocrinology 2006;248(1-2):199-203.
2006: Gillian M Allan; Christian Bubert; Nigel Vicker; Andrew Smith; Helena Tutill; Atul Purohit; Michael J Reed; Barry V L Potter
Novel, potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Molecular and cellular endocrinology 2006;248(1-2):204-7.
2006: Xiangdong SU; Nigel Vicker; Dharshini Ganeshapillai; Andrew Smith; Atul Purohit; Michael J Reed; Barry V L Potter
Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
Molecular and cellular endocrinology 2006;248(1-2):214-7.
2006: Susannah J Stanway; Atul Purohit; L W Lawrence Woo; Saulat Sufi; David M Vigushin; Rebecca Ward; Richard H Wilson; Frank Z Stanczyk; Nicola Dobbs; Elena Kulinskaya; Moira Elliott; Barry V L Potter; Michael J Reed; R Charles Coombes
Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(5):1585-92.
2006: Gillian M Allan; Harshani R Lawrence; Josephine Cornet; Christian Bubert; Delphine S Fischer; Nigel Vicker; Andrew Smith; Helena Tutill; Atul Purohit; Joanna M Day; Mary F Mahon; Michael J Reed; Barry V L Potter
Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Journal of medicinal chemistry 2006;49(4):1325-45.
2006: Simon P Newman; Christopher R Ireson; Helena Tutill; Joanna M Day; Michael F C Parsons; Mathew P Leese; Barry V L Potter; Michael J Reed; Atul Purohit
The role of 17beta-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells.
Cancer research 2006;66(1):324-30.
2005: Bindumalini Raobaikady; Michael J Reed; Mathew P Leese; Barry V L Potter; Atul Purohit
Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono- and bis-3-O-sulphamates.
International journal of cancer. Journal international du cancer 2005;117(1):150-9.
2005: Delphine S Fischer; Gillian M Allan; Christian Bubert; Nigel Vicker; Andrew Smith; Helena Tutill; Atul Purohit; Lynn Wood; Graham Packham; Mary F Mahon; Michael J Reed; Barry V L Potter
E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Journal of medicinal chemistry 2005;48(18):5749-70.
2005: Mathew P Leese; Hatem A M Hejaz; Mary F Mahon; Simon P Newman; Atul Purohit; Michael J Reed; Barry V L Potter
A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
Journal of medicinal chemistry 2005;48(16):5243-56.
2005: Matthew D Lloyd; Nethaji Thiyagarajan; Yaik T Ho; L W Lawrence Woo; Oliver B Sutcliffe; Atul Purohit; Michael J Reed; K Ravi Acharya; Barry V L Potter
First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.
Biochemistry 2005;44(18):6858-66.
2005: Harshani R Lawrence; Nigel Vicker; Gillian M Allan; Andrew Smith; Mary F Mahon; Helena Tutill; Atul Purohit; Michael J Reed; Barry V L Potter
Novel and potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Journal of medicinal chemistry 2005;48(8):2759-62.
2005: Michael J Reed; Atul Purohit; L W Lawrence Woo; Simon P Newman; Barry V L Potter
Steroid sulfatase: molecular biology, regulation, and inhibition.
Endocrine reviews 2005;26(2):171-202.
2005: Mathew P Leese; Bertrand Leblond; Simon P Newman; Atul Purohit; Michael J Reed; Barry V L Potter
Anti-cancer activities of novel D-ring modified 2-substituted estrogen-3-O-sulfamates.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):239-51.
2005: Bindumalini Raobaikady; Joanna M Day; Atul Purohit; Barry V L Potter; Michael J Reed
The nature of inhibition of steroid sulphatase activity by tibolone and its metabolites.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):229-37.
2005: T Utsumi; Mathew P Leese; Surinder K Chander; K Gaukroger; Atul Purohit; Simon P Newman; Barry V L Potter; Michael J Reed
The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):219-27.
2005: Atul Purohit; Margaret W Ghilchik; Mathew P Leese; Barry V L Potter; Michael J Reed
Regulation of aromatase activity by cytokines, PGE2 and 2-methoxyoestrone-3-O-sulphamate in fibroblasts derived from normal and malignant breast tissues.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):167-72.
2005: Paul M Wood; L W Lawrence Woo; Anna Humphreys; Surinder K Chander; Atul Purohit; Michael J Reed; Barry V L Potter
A letrozole-based dual aromatase-sulphatase inhibitor with in vivo activity.
The Journal of steroid biochemistry and molecular biology 2005;94(1-3):123-30.
2005: Matthew D Lloyd; Richard L Pederick; Ramanathan Natesh; L W Lawrence Woo; Atul Purohit; Michael J Reed; K Ravi Acharya; Barry V L Potter
Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent.
The Biochemical journal 2005;385(Pt 3):715-20.
2004: Christopher R Ireson; Surinder K Chander; Atul Purohit; David C Parish; L W Lawrence Woo; Barry V L Potter; Michael J Reed
Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats.
British journal of cancer 2004;91(7):1399-404.
2004: Surinder K Chander; Atul Purohit; L W Lawrence Woo; Barry V L Potter; Michael J Reed
The role of steroid sulphatase in regulating the oestrogenicity of oestrogen sulphamates.
Biochemical and biophysical research communications 2004;322(1):217-22.
2004: Xiangdong SU; Harshani R Lawrence; Dharshini Ganeshapillai; Adrian Cruttenden; Atul Purohit; Michael J Reed; Nigel Vicker; Barry V L Potter
Novel 18beta-glycyrrhetinic acid analogues as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenases.
Bioorganic & medicinal chemistry 2004;12(16):4439-57.
2004: Nigel Vicker; Xiangdong SU; Harshani R Lawrence; Adrian Cruttenden; Atul Purohit; Michael J Reed; Barry V L Potter
A novel 18 beta-glycyrrhetinic acid analogue as a potent and selective inhibitor of 11 beta-hydroxysteroid dehydrogenase 2.
Bioorganic & medicinal chemistry letters 2004;14(12):3263-7.
2004: Mathew P Leese; Simon P Newman; Atul Purohit; Michael J Reed; Barry V L Potter
2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents.
Bioorganic & medicinal chemistry letters 2004;14(12):3135-8.
2004: Hatem A M Hejaz; L W Lawrence Woo; Atul Purohit; Michael J Reed; Barry V L Potter
Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase.
Bioorganic & medicinal chemistry 2004;12(10):2759-72.
2004: Julie E Reed; L W Lawrence Woo; James J Robinson; Bertrand Leblond; Mathew P Leese; Atul Purohit; Michael J Reed; Barry V L Potter
2-difluoromethyloestrone 3-O-sulphamate, a highly potent steroid sulphatase inhibitor.
Biochemical and biophysical research communications 2004;317(1):169-75.
2004: Simon P Newman; Mathew P Leese; Atul Purohit; David R C James; Catherine E Rennie; Barry V L Potter; Michael J Reed
Inhibition of in vitro angiogenesis by 2-methoxy- and 2-ethyl-estrogen sulfamates.
International journal of cancer. Journal international du cancer 2004;109(4):533-40.
2004: Christopher R Ireson; Surinder K Chander; Atul Purohit; S Perera; Simon P Newman; David C Parish; Mathew P Leese; A C Smith; Barry V L Potter; Michael J Reed
Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents.
British journal of cancer 2004;90(4):932-7.
2003: Richard A Glennon; Maha Khalifa Daoud; Malgorzata Dukat; Milt Teitler; Katharine Herrick-Davis; Atul Purohit; Hasan Syed
Arylguanidine and arylbiguanide binding at 5-HT3 serotonin receptors: a QSAR study.
Bioorganic & medicinal chemistry 2003;11(20):4449-54.
2003: Atul Purohit; L W Lawrence Woo; Surinder K Chander; Simon P Newman; Christopher R Ireson; Y Ho; A Grasso; Mathew P Leese; Barry V L Potter; Michael J Reed
Steroid sulphatase inhibitors for breast cancer therapy.
The Journal of steroid biochemistry and molecular biology 2003;86(3-5):423-32.
2003: Nantaka Khorana; Carol Smith; Katharine Herrick-Davis; Atul Purohit; Milt Teitler; Brian Grella; Malgorzata Dukat; Richard A Glennon
Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.
Journal of medicinal chemistry 2003;46(18):3930-7.
2003: Yaik T Ho; Simon P Newman; Atul Purohit; Mathew P Leese; Barry V L Potter; Michael J Reed
The effects of 2-methoxy oestrogens and their sulphamoylated derivatives in conjunction with TNF-alpha on endothelial and fibroblast cell growth, morphology and apoptosis.
The Journal of steroid biochemistry and molecular biology 2003;86(2):189-96.
2003: L W Lawrence Woo; Oliver B Sutcliffe; Christian Bubert; Anna Grasso; Surinder K Chander; Atul Purohit; Michael J Reed; Barry V L Potter
First dual aromatase-steroid sulfatase inhibitors.
Journal of medicinal chemistry 2003;46(15):3193-6.
2003: Yaik T Ho; Atul Purohit; Nigel Vicker; Simon P Newman; James J Robinson; Mathew P Leese; Dharshini Ganeshapillai; L W Lawrence Woo; Barry V L Potter; Michael J Reed
Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates.
Biochemical and biophysical research communications 2003;305(4):909-14.
2003: Delphine S Fischer; L W Lawrence Woo; Mary F Mahon; Atul Purohit; Michael J Reed; Barry V L Potter
D-ring modified estrone derivatives as novel potent inhibitors of steroid sulfatase.
Bioorganic & medicinal chemistry 2003;11(8):1685-700.
2003: Ashraf A Rahman; Maha Khalifa Daoud; Malgorzata Dukat; Katharine Herrick-Davis; Atul Purohit; Milt Teitler; Antonia Taveres do Amaral; Alberto Malvezzi; Richard A Glennon
Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG).
Bioorganic & medicinal chemistry letters 2003;13(6):1119-23.
2003: Nigel Vicker; Yaikat Ho; James Robinson; Lawrence L W Woo; Atul Purohit; Michael J Reed; Barry V L Potter
Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II.
Bioorganic & medicinal chemistry letters 2003;13(5):863-5.
2003: Nantaka Khorana; Atul Purohit; Katharine Herrick-Davis; Milt Teitler; Richard A Glennon
gamma-Carbolines: binding at 5-HT5A serotonin receptors.
Bioorganic & medicinal chemistry 2003;11(5):717-22.
2003: Atul Purohit; A Singh; Margaret W Ghilchik; O Serlupi-Crescenzi; Michael J Reed
Inhibition of IL-6+IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts.
British journal of cancer 2003;88(4):630-5.
2003: Bindumalini Raobaikady; Atul Purohit; Surinder K Chander; L W Lawrence Woo; Mathew P Leese; Barry V L Potter; Michael J Reed
Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):351-8.
2003: Delphine S Fischer; Surinder K Chander; L W Lawrence Woo; Janine C Fenton; Atul Purohit; Michael J Reed; Barry V L Potter
Novel D-ring modified steroid derivatives as potent, non-estrogenic, steroid sulfatase inhibitors with in vivo activity.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):343-9.
2003: Christopher R Ireson; David C Parish; Atul Purohit; L W Lawrence Woo; Barry V L Potter; Surinder K Chander; Michael J Reed
Development of a sensitive high-performance liquid chromatography method for the detection of 667 COUMATE in vivo.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):337-42.
2003: Joanna M Day; Simon P Newman; Alexander Comninos; Claire Solomon; Atul Purohit; Mathew P Leese; Barry V L Potter; Michael J Reed
The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):317-25.
2003: R N Suzuki; Simon P Newman; Atul Purohit; Mathew P Leese; Barry V L Potter; Michael J Reed
Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):269-78.
2002: Nicola M Howarth; Atul Purohit; James J Robinson; Nigel Vicker; Michael J Reed; Barry V L Potter
Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity: homology model construction and docking studies.
Biochemistry 2002;41(50):14801-14.
2002: Atul Purohit; Michael J Reed
Regulation of estrogen synthesis in postmenopausal women.
Steroids 2002;67(12):979-83.
2002: Atul Purohit; Simon P Newman; Michael J Reed
The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer.
Breast cancer research : BCR 2002;4(2):65-9.
2002: Atul Purohit; B Malini; C Hooymans; Simon P Newman
Inhibition of oestrone sulphatase activity by tibolone and its metabolites.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(1):1-6.
2001: David C Parish; Atul Purohit; A Singh; J Rosankiewicz; Margaret W Ghilchik; Michael J Reed
Peptide inhibition of cytokine-stimulated aromatase activity in breast tissue fibroblasts.
The Journal of steroid biochemistry and molecular biology 2001;79(1-5):165-72.
2001: Michael J Reed; Atul Purohit
Aromatase regulation and breast cancer.
Clinical endocrinology 2001;54(5):563-71.
2001: Atul Purohit; L W Lawrence Woo; D Barrow; Hatem A M Hejaz; R I Nicholson; Barry V L Potter; Michael J Reed
Non-steroidal and steroidal sulfamates: new drugs for cancer therapy.
Molecular and cellular endocrinology 2001;171(1-2):129-35.
2001: Barna Budai; Irén Számel; Zoltán Sulyok; M Német; M Bak; Szabolcs Ottó; Michael J Reed; Atul Purohit; David C Parish; Judit Kralovánszky
Characteristics of cystic breast disease with special regard to breast cancer development.
Anticancer research 2001;21(1B):749-52.
2000: Simon P Newman; Atul Purohit; Margaret W Ghilchik; Barry V L Potter; Michael J Reed
Regulation of steroid sulphatase expression and activity in breast cancer.
The Journal of steroid biochemistry and molecular biology 2000;75(4-5):259-64.
2000: B Malini; Atul Purohit; Dharshini Ganeshapillai; L W Lawrence Woo; Barry V L Potter; Michael J Reed
Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates.
The Journal of steroid biochemistry and molecular biology 2000;75(4-5):253-8.
2000: J Bonser; J Walker; Atul Purohit; Michael J Reed; Barry V L Potter; DS Willis; Stephen Franks; Helen D Mason
Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production.
The Journal of endocrinology 2000;167(3):465-71.
2000: L MacCarthy-Morrogh; Paul A Townsend; Atul Purohit; Michael J Reed; Graham Packham
Differential effects of estrone and estrone-3-O-sulfamate derivatives on mitotic. Arrest, apoptosis, and microtubule assembly in human breast cancer cells.
Cancer research 2000;60(19):5441-50.
2000: Lawrence L W Woo; Atul Purohit; B Malini; Michael J Reed; Barry V L Potter
Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates.
Chemistry & biology 2000;7(10):773-91.
2000: Barna Budai; Irén Számel; Zoltán Sulyok; M Németh; M Bak; Judit Kralovánszky; Szabolcs Ottó; István Besznyák; Atul Purohit; David C Parish; Michael J Reed
Influence of hormonal status of patients with cystic disease on the composition of cyst fluid and breast cancer risk.
Anticancer research 2000;20(5C):3879-86.
2000: Atul Purohit; L W Lawrence Woo; Barry V L Potter; Michael J Reed
In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE.
Cancer research 2000;60(13):3394-6.
2000: A Singh; Atul Purohit; Hatem A M Hejaz; Barry V L Potter; Michael J Reed
Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate.
Molecular and cellular endocrinology 2000;160(1-2):61-6.
2000: Atul Purohit; Hatem A M Hejaz; L Walden; L MacCarthy-Morrogh; Graham Packham; Barry V L Potter; Michael J Reed
The effect of 2-methoxyoestrone-3-O-sulphamate on the growth of breast cancer cells and induced mammary tumours.
International journal of cancer. Journal international du cancer 2000;85(4):584-9.
2000: Atul Purohit; B Budai; D Y Wang; E L Willemsen; A de Winkel; David C Parish; Margaret W Ghilchik; I Szamel; Michael J Reed
Modulation of oestrone sulphate formation and hydrolysis in breast cancer cells by breast cyst fluid from British and Hungarian women.
British journal of cancer 2000;82(2):492-6.
1999: Hatem A M Hejaz; Atul Purohit; Mary F Mahon; Michael J Reed; Barry V L Potter
Synthesis and biological activity of the superestrogen (E)-17-oximino-3-O-sulfamoyl-1,3,5(10)-estratriene: x-ray crystal structure of (E)-17-oximino-3-hydroxy-1,3,5(10)-estratriene.
Journal of medicinal chemistry 1999;42(16):3188-92.
1999: Atul Purohit; A Singh; Margaret W Ghilchik; Michael J Reed
Inhibition of tumor necrosis factor alpha-stimulated aromatase activity by microtubule-stabilizing agents, paclitaxel and 2-methoxyestradiol.
Biochemical and biophysical research communications 1999;261(1):214-7.
1999: A Singh; Atul Purohit; Margaret W Ghilchik; Michael J Reed
The regulation of aromatase activity in breast fibroblasts: the role of interleukin-6 and prostaglandin E2.
Endocrine-related cancer 1999;6(2):139-47.
1999: Atul Purohit; Hatem A M Hejaz; L W Lawrence Woo; A E van Strien; Barry V L Potter; Michael J Reed
Recent advances in the development of steroid sulphatase inhibitors.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):227-38.
1999: Atul Purohit; C V de Giovani; Michael J Reed
The regulation of oestrone sulphate formation in breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1999;68(3-4):129-35.
1999: Atul Purohit; A Singh; Michael J Reed
Regulation of steroid sulphatase and oestradiol 17 beta-hydroxysteroid dehydrogenase in breast cancer.
Biochemical Society transactions 1999;27(2):323-7.
1998: L W Lawrence Woo; Nicola M Howarth; Atul Purohit; Hatem A M Hejaz; Michael J Reed; Barry V L Potter
Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase.
Journal of medicinal chemistry 1998;41(7):1068-83.
1998: Atul Purohit; K A Vernon; A E Hummelinck; L W Lawrence Woo; Hatem A M Hejaz; Barry V L Potter; Michael J Reed
The development of A-ring modified analogues of oestrone-3-O-sulphamate as potent steroid sulphatase inhibitors with reduced oestrogenicity.
The Journal of steroid biochemistry and molecular biology 1998;64(5-6):269-75.
1998: Atul Purohit; Barry V L Potter; M G Parker; Michael J Reed
Steroid sulphatase: expression, isolation and inhibition for active-site identification studies.
Chemico-biological interactions 1998;109(1-3):183-93.
1998: A Singh; Atul Purohit; N G Coldham; Margaret W Ghilchik; Michael J Reed
Biochemical control of breast aromatase.
Breast cancer research and treatment 1998;49 Suppl 1():S9-14; discussion S33-7.
1997: Michael J Reed; Atul Purohit
Breast cancer and the role of cytokines in regulating estrogen synthesis: an emerging hypothesis.
Endocrine reviews 1997;18(5):701-15.
1997: Atul Purohit; V A Froome; D Y Wang; Barry V L Potter; Michael J Reed
Measurement of oestrone sulphatase activity in white blood cells to monitor in vivo inhibition of steroid sulphatase activity by oestrone-3-O-sulphamate.
The Journal of steroid biochemistry and molecular biology 1997;62(1):45-51.
1997: A Singh; Atul Purohit; L J Duncan; Kefah Mokbel; Margaret W Ghilchik; Michael J Reed
Control of aromatase activity in breast tumours: the role of the immune system.
The Journal of steroid biochemistry and molecular biology 1997;61(3-6):185-92.
1997: Nicola M Howarth; Atul Purohit; Michael J Reed; Barry V L Potter
Estrone sulfonates as inhibitors of estrone sulfatase.
Steroids 1997;62(4):346-50.
1996: Atul Purohit; L W Lawrence Woo; A Singh; C J Winterborn; B V Potter; Michael J Reed
In vivo activity of 4-methylcoumarin-7-O-sulfamate, a nonsteroidal, nonestrogenic steroid sulfatase inhibitor.
Cancer research 1996;56(21):4950-5.
1996: Atul Purohit; DY Wang; Margaret W Ghilchik; Michael J Reed
Regulation of aromatase and sulphatase in breast tumour cells.
The Journal of endocrinology 1996;150 Suppl():S65-71.
1996: M I Hidalgo Aragones; Atul Purohit; D Parish; U G Sahm; CW Pouton; B V Potter; Michael J Reed
Pharmacokinetics of oestrone-3-O-sulphamate.
The Journal of steroid biochemistry and molecular biology 1996;58(5-6):611-7.
1996: Atul Purohit; Michael J Reed; N C Morris; G J Williams; B V Potter
Regulation and inhibition of steroid sulfatase activity in breast cancer.
Annals of the New York Academy of Sciences 1996;784():40-9.
1996: L W Lawrence Woo; Atul Purohit; Michael J Reed; B V Potter
Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates.
Journal of medicinal chemistry 1996;39(7):1349-51.
1996: L W Lawrence Woo; Mark Lightowler; Atul Purohit; Michael J Reed; B V Potter
Heteroatom-substituted analogues of the active-site directed inhibitor estra-1,3,5(10)-trien-17-one-3-sulphamate inhibit estrone sulphatase by a different mechanism.
The Journal of steroid biochemistry and molecular biology 1996;57(1-2):79-88.
1995: A Singh; Atul Purohit; DY Wang; L J Duncan; Margaret W Ghilchik; Michael J Reed
IL-6sR: release from MCF-7 breast cancer cells and role in regulating peripheral oestrogen synthesis.
The Journal of endocrinology 1995;147(2):R9-12.
1995: Atul Purohit; Margaret W Ghilchik; L Duncan; DY Wang; A Singh; M M Walker; Michael J Reed
Aromatase activity and interleukin-6 production by normal and malignant breast tissues.
The Journal of clinical endocrinology and metabolism 1995;80(10):3052-8.
1995: Atul Purohit; G J Williams; C J Roberts; B V Potter; Michael J Reed
In vivo inhibition of oestrone sulphatase and dehydroepiandrosterone sulphatase by oestrone-3-O-sulphamate.
International journal of cancer. Journal international du cancer 1995;63(1):106-11.
1995: Atul Purohit; G J Williams; N M Howarth; B V Potter; Michael J Reed
Inactivation of steroid sulfatase by an active site-directed inhibitor, estrone-3-O-sulfamate.
Biochemistry 1995;34(36):11508-14.
1995: O Chapman; Atul Purohit; DY Wang; Margaret W Ghilchik; Michael J Reed
Oestrone sulphatase activity in normal and malignant breast tissues: relationship with tumour location.
Anticancer research 1995;15(4):1467-71.
1995: Michael J Reed; Atul Purohit; L J Duncan; A Singh; C J Roberts; G J Williams; B V Potter
The role of cytokines and sulphatase inhibitors in regulating oestrogen synthesis in breast tumours.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):413-20.
1994: F Macdiarmid; D Wang; L J Duncan; Atul Purohit; M W Ghilchick; Michael J Reed
Stimulation of aromatase activity in breast fibroblasts by tumor necrosis factor alpha.
Molecular and cellular endocrinology 1994;106(1-2):17-21.
1994: Atul Purohit; S Dauvois; M G Parker; B V Potter; G J Williams; Michael J Reed
The hydrolysis of oestrone sulphate and dehydroepiandrosterone sulphate by human steroid sulphatase expressed in transfected COS-1 cells.
The Journal of steroid biochemistry and molecular biology 1994;50(1-2):101-4.
1994: Atul Purohit; N M Howarth; B V Potter; Michael J Reed
Inhibition of steroid sulphatase activity by steroidal methylthiophosphonates: potential therapeutic agents in breast cancer.
The Journal of steroid biochemistry and molecular biology 1994;48(5-6):523-7.
1994: N M Howarth; Atul Purohit; Michael J Reed; B V Potter
Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential.
Journal of medicinal chemistry 1994;37(2):219-21.
1993: Michael J Reed; L Topping; N G Coldham; Atul Purohit; Margaret W Ghilchik; V H James
Control of aromatase activity in breast cancer cells: the role of cytokines and growth factors.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):589-96.
1993: L Duncan; Atul Purohit; N M Howarth; B V Potter; Michael J Reed
Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer.
Cancer research 1993;53(2):298-303.
1992: Atul Purohit; A A Riaz; Margaret W Ghilchik; Michael J Reed
The origin of oestrone sulphate in normal and malignant breast tissues in postmenopausal women.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1992;24(11):532-6.
1992: D A Williams; Atul Purohit; Michael J Reed
Immunochemical specificity of placental NADPH cytochrome c (P-450) reductase in neoplastic and non-neoplastic human tissue.
The Journal of steroid biochemistry and molecular biology 1992;43(6):515-22.
1992: Atul Purohit; Adrienne M Flanagan; Michael J Reed
Estrogen synthesis by osteoblast cell lines.
Endocrinology 1992;131(4):2027-9.
1992: V H James; Michael J Reed; Atul Purohit
Inhibition of oestrogen synthesis in postmenopausal women with breast cancer.
The Journal of steroid biochemistry and molecular biology 1992;43(1-3):149-53.
1992: Atul Purohit; Michael J Reed
Oestrogen sulphatase activity in hormone-dependent and hormone-independent breast-cancer cells: modulation by steroidal and non-steroidal therapeutic agents.
International journal of cancer. Journal international du cancer 1992;50(6):901-5.
1992: Atul Purohit; O Chapman; L Duncan; Michael J Reed
Modulation of oestrone sulphatase activity in breast cancer cell lines by growth factors.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):563-6.
1991: Michael J Reed; A Singh; Margaret W Ghilchik; N G Coldham; Atul Purohit
Regulation of oestradiol 17 beta hydroxysteroid dehydrogenase in breast tissues: the role of growth factors.
The Journal of steroid biochemistry and molecular biology 1991;39(5B):791-8.
1990: Michael J Reed; L C Lai; A M Owen; A Singh; N G Coldham; Atul Purohit; Margaret W Ghilchik; N A Shaikh; V H James
Effect of treatment with 4-hydroxyandrostenedione on the peripheral conversion of androstenedione to estrone and in vitro tumor aromatase activity in postmenopausal women with breast cancer.
Cancer research 1990;50(1):193-6.
1989: Atul Purohit; L C Lai; A Singh; N G Coldham; Margaret W Ghilchik; Michael J Reed; V H James
The effect of medroxyprogesterone acetate on aromatase and DNA polymerase alpha activities in breast tumours.
Journal of steroid biochemistry 1989;34(1-6):443-6.