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Pamela Puttfarcken

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Regina M Reilly; Robert G Schmidt; Jason A Segreti; Teresa M Turner; Eric A Voight; LaGeisha Lewis; Patrick W Mantyh; Heath A McDonald; Torben R Neelands; Madhavi Pai; Pamela S Puttfarcken; Jun Chen; Jerome F Daanen; Connie R Faltynek; Pamela H Franklin; Joseph R Ghilardi; Arthur Gomtsyan; Ping Han; Shailen K Joshi; Michael E Kort; Philip R Kym
Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature.
John Malysz; David J Anderson; Jens H Grønlien; Jianguo Ji; William H Bunnelle; Monika Håkerud; Kirten Thorin-Hagene; Hilde Ween; Rosalind Helfrich; Min Hu; Earl Gubbins; Sujatha M Gopalakrishnan; Pamela S Puttfarcken; Clark A Briggs; Jinhe Li; Michael D Meyer; Tino Dyhring; Philip K Ahring; Elsebet Ø Nielsen; Dan Peters; Daniel B Timmermann; Murali Gopalakrishnan
In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.
Pamela S Puttfarcken; Ping Han; Shailen K Joshi; Torben R Neelands; Donna M Gauvin; Scott J Baker; La Geisha R Lewis; Bruce R Bianchi; Joe Mikusa; John R Koenig; Richard J Perner; Michael E Kort; Prisca Honore; Connie R Faltynek; Philip R Kym; Regina M Reilly
A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model.

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All Publications

2012: Regina M Reilly; Robert G Schmidt; Jason A Segreti; Teresa M Turner; Eric A Voight; LaGeisha Lewis; Patrick W Mantyh; Heath A McDonald; Torben R Neelands; Madhavi Pai; Pamela S Puttfarcken; Jun Chen; Jerome F Daanen; Connie R Faltynek; Pamela H Franklin; Joseph R Ghilardi; Arthur Gomtsyan; Ping Han; Shailen K Joshi; Michael E Kort; Philip R Kym
Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature.
The Journal of pharmacology and experimental therapeutics 2012;342(2):416-28.
2010: John Malysz; David J Anderson; Jens H Grønlien; Jianguo Ji; William H Bunnelle; Monika Håkerud; Kirten Thorin-Hagene; Hilde Ween; Rosalind Helfrich; Min Hu; Earl Gubbins; Sujatha M Gopalakrishnan; Pamela S Puttfarcken; Clark A Briggs; Jinhe Li; Michael D Meyer; Tino Dyhring; Philip K Ahring; Elsebet Ø Nielsen; Dan Peters; Daniel B Timmermann; Murali Gopalakrishnan
In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.
The Journal of pharmacology and experimental therapeutics 2010;334(3):863-74.
2010: Pamela S Puttfarcken; Ping Han; Shailen K Joshi; Torben R Neelands; Donna M Gauvin; Scott J Baker; La Geisha R Lewis; Bruce R Bianchi; Joe Mikusa; John R Koenig; Richard J Perner; Michael E Kort; Prisca Honore; Connie R Faltynek; Philip R Kym; Regina M Reilly
A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model.
Pain 2010;150(2):319-26.
2010: Brian S Brown; Ryan G Keddy; Richard J Perner; Stanley Didomenico; John R Koenig; Tammie K Jinkerson; Steven M Hannick; Heath A McDonald; Bruce R Bianchi; Prisca Honore; Pamela S Puttfarcken; Robert B Moreland; Kennan Marsh; Connie R Faltynek; Abel Lee
Discovery of TRPV1 antagonist ABT-116.
Bioorganic & medicinal chemistry letters 2010;20(11):3291-4.
2010: Bruce R Bianchi; Rachid El Kouhen; Jun Chen; Pamela S Puttfarcken
Binding of [(3)H]A-778317 to native transient receptor potential vanilloid-1 (TRPV1) channels in rat dorsal root ganglia and spinal cord.
European journal of pharmacology 2010;633(1-3):15-23.
2010: Torben R Neelands; Xu-Feng Zhang; Heath McDonald; Pamela S Puttfarcken
Differential effects of temperature on acid-activated currents mediated by TRPV1 and ASIC channels in rat dorsal root ganglion neurons.
Brain research 2010;1329():55-66.
2009: Robert S Bitner; Arthur L Nikkel; Stella Markosyan; Stephani Otte; Pamela S Puttfarcken; Murali Gopalakrishnan
Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.
Brain research 2009;1265():65-74.
2008: Heath A McDonald; Torben R Neelands; Michael Kort; Ping Han; Melissa H Vos; Connie R Faltynek; Robert B Moreland; Pamela S Puttfarcken
Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia.
European journal of pharmacology 2008;596(1-3):62-9.
2007: Bruce R Bianchi; Rachid El Kouhen; Torben R Neelands; Abel Lee; Arthur Gomtsyan; Shirish N Raja; Sriajan N Vaidyanathan; Bruce W Surber; Heath A McDonald; Carol S Surowy; Connie R Faltynek; Robert B Moreland; Michael F Jarvis; Pamela S Puttfarcken
[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor.
The Journal of pharmacology and experimental therapeutics 2007;323(1):285-93.
2007: William H Bunnelle; Jerome F Daanen; Keith B Ryther; Michael R Schrimpf; Michael J Dart; Arianna Gelain; Michael D Meyer; Jennifer M Frost; David J Anderson; Michael Buckley; Peter Curzon; YING-JUN CAO; Pamela S Puttfarcken; Xenia Searle; Jianguo Ji; C Brent Putman; Carol S Surowy; Lucio Toma; Daniela Barlocco
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.
Journal of medicinal chemistry 2007;50(15):3627-44.
2007: Min Hu; Mark E Schurdak; Pamela S Puttfarcken; Rachid El Kouhen; Murali Gopalakrishnan; Jinhe Li
High content screen microscopy analysis of A beta 1-42-induced neurite outgrowth reduction in rat primary cortical neurons: neuroprotective effects of alpha 7 neuronal nicotinic acetylcholine receptor ligands.
Brain research 2007;1151():227-35.
2006: Melissa H Vos; Torben R Neelands; Heath A McDonald; Won Choi; Paul Kroeger; Pamela S Puttfarcken; Connie R Faltynek; Robert B Moreland; Ping Han
TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells.
Journal of neurochemistry 2006;99(4):1088-102.
2006: Bruce R Bianchi; Abel Lee; Michael F Jarvis; Rachid El Kouhen; Robert B Moreland; Connie R Faltynek; Pamela S Puttfarcken
Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system.
European journal of pharmacology 2006;537(1-3):20-30.
2005: YING-JUN CAO; Carol S Surowy; Pamela S Puttfarcken
Nicotinic acetylcholine receptor-mediated [3H]dopamine release from hippocampus.
The Journal of pharmacology and experimental therapeutics 2005;312(3):1298-304.
2005: YING-JUN CAO; Carol S Surowy; Pamela S Puttfarcken
Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release.
Neuropharmacology 2005;48(1):72-9.
2002: Iris Jacobs; David J Anderson; Carol S Surowy; Pamela S Puttfarcken
Differential regulation of nicotinic receptor-mediated neurotransmitter release following chronic (-)-nicotine administration.
Neuropharmacology 2002;43(5):847-56.
2000: Pamela S Puttfarcken; Iris Jacobs; Connie R Faltynek
Characterization of nicotinic acetylcholine receptor-mediated [(3)H]-dopamine release from rat cortex and striatum.
Neuropharmacology 2000;39(13):2673-80.
2000: David J Anderson; Pamela S Puttfarcken; Iris Jacobs; Connie R Faltynek
Assessment of nicotinic acetylcholine receptor-mediated release of [(3)H]-norepinephrine from rat brain slices using a new 96-well format assay.
Neuropharmacology 2000;39(13):2663-72.
2000: Robert S Bitner; Arthur L Nikkel; Peter Curzon; Diana L Donnelly-Roberts; Pamela S Puttfarcken; Marian T Namovic; I C Jacobs; Michael D Meyer; Michael W Decker
Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat.
Brain research 2000;871(1):66-74.
1998: Michael W Decker; Peter Curzon; Mark W Holladay; Arthur L Nikkel; Robert S Bitner; AW Bannon; Diana L Donnelly-Roberts; Pamela S Puttfarcken; TA Kuntzweiler; Clark A Briggs; Michael Williams; Stephen P Arneric
The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594.
Journal of physiology, Paris 1998;92(3-4):221-4.
1998: Diana L Donnelly-Roberts; Pamela S Puttfarcken; TA Kuntzweiler; Clark A Briggs; David J Anderson; Jeffrey Campbell; M Piattoni-Kaplan; David G McKenna; JT Wasicak; Mark W Holladay; Michael Williams; Stephen P Arneric
ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.
The Journal of pharmacology and experimental therapeutics 1998;285(2):777-86.
1998: AW Bannon; Michael W Decker; Mark W Holladay; Peter Curzon; Diana L Donnelly-Roberts; Pamela S Puttfarcken; Robert S Bitner; A Diaz; A H Dickenson; Roger D Porsolt; Michael Williams; Stephen P Arneric
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
Science (New York, N.Y.) 1998;279(5347):77-81.
1997: Pamela S Puttfarcken; Arlene M Manelli; Stephen P Arneric; Diana L Donnelly-Roberts
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
Journal of neurochemistry 1997;69(3):930-8.
1997: Evelyn Cadman; Pamela S Puttfarcken
Beta-amyloid peptides initiate the complement cascade without producing a comparable effect on the terminal pathway in vitro.
Experimental neurology 1997;146(2):388-94.
1997: Pamela S Puttfarcken; Arlene M Manelli; M T Falduto; Godfrey S Getz; Mary Jo Ladu
Effect of apolipoprotein E on neurite outgrowth and beta-amyloid-induced toxicity in developing rat primary hippocampal cultures.
Journal of neurochemistry 1997;68(2):760-9.
1997: Arlene M Manelli; Evelyn Cadman; K Shiosaki; Pamela S Puttfarcken
The presence of the complement cascade does not lead to neuronal cell death in primary hippocampal cultures.
Brain research bulletin 1997;42(3):187-93.
1996: Pamela S Puttfarcken; Arlene M Manelli; J Neilly; D E Frail
Inhibition of age-induced beta-amyloid neurotoxicity in rat hippocampal cells.
Experimental neurology 1996;138(1):73-81.
1995: Arlene M Manelli; Pamela S Puttfarcken
beta-Amyloid-induced toxicity in rat hippocampal cells: in vitro evidence for the involvement of free radicals.
Brain research bulletin 1995;38(6):569-76.