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Nigel Pyne

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David G Watson; Leon Williamson; Francesca Tonelli; Manal Alossaimi; Evgeny Berdyshev; Robert Bittman; Edmond Chan; Irina Gorshkova; Nigel J Pyne; Susan Pyne
The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.
Francesca Tonelli; David G Watson; Leon Williamson; Rothwelle J Tate; Manal Alossaimi; Robert Bittman; Edmond Chan; Nigel J Pyne; Susan Pyne
The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.
Abdullah A Y Gibriel; Harold M Hammer; Nigel J Pyne; Emma Rawson-Lax; Rothwelle J Tate; Justice N A Tettey; Yongbin Yu; Carolyn A Converse
The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism.

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2013: David G Watson; Leon Williamson; Francesca Tonelli; Manal Alossaimi; Evgeny Berdyshev; Robert Bittman; Edmond Chan; Irina Gorshkova; Nigel J Pyne; Susan Pyne
The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.
Cellular signalling 2013;25(4):1011-7.
2013: Francesca Tonelli; David G Watson; Leon Williamson; Rothwelle J Tate; Manal Alossaimi; Robert Bittman; Edmond Chan; Nigel J Pyne; Susan Pyne
The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.
British journal of pharmacology 2013;168(6):1497-505.
2013: Abdullah A Y Gibriel; Harold M Hammer; Nigel J Pyne; Emma Rawson-Lax; Rothwelle J Tate; Justice N A Tettey; Yongbin Yu; Carolyn A Converse
The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism.
Gene 2013;515(1):155-8.
2013: Jan Ohotski; Clare Orange; Joanne Edwards; Beatrix Elsberger; Elizabeth Mallon; Susan Pyne; Carol Watson; Nigel J Pyne
Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer.
International journal of cancer. Journal international du cancer 2013;132(3):605-16.
2013: Nigel J Pyne; Susan Pyne
Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer.
Cancer cell 2013;23(1):5-7.
2013: Susan Pyne; Nigel J Pyne
New perspectives on the role of sphingosine 1-phosphate in cancer.
Handbook of experimental pharmacology 2013;216():55-71.
2013: Nigel J Pyne; Gerald Dubois; Susan Pyne
Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis.
Biochimica et biophysica acta 2013;1831(1):228-38.
2012: Keng Gat Lim; Stuart M Pitson; Susan Pyne; Francesca Tonelli; Evgeny Berdyshev; Robert Bittman; Irina Gorshkova; Tamara Leclercq; Nigel J Pyne
Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.
The international journal of biochemistry & cell biology 2012;44(9):1457-64.
2012: Keng Gat Lim; Alexander I Gray; Susan Pyne; Nigel J Pyne
Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival.
British journal of pharmacology 2012;166(5):1605-16.
2012: J Ohotski; C Orange; Nigel J Pyne; Susan Pyne; J Doughty; B Elsberger; Jaclyn S Long; E Mallon; J Edwards
Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.
British journal of cancer 2012;106(8):1453-9.
2012: Nigel J Pyne; Joanne Edwards; Keng Gat Lim; Jaclyn S Long; Francesca Tonelli; Susan Pyne
Sphingosine 1-phosphate signalling in cancer.
Biochemical Society transactions 2012;40(1):94-100.
2012: Susan Pyne; Joanne Edwards; Jan Ohotski; Nigel J Pyne
Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers.
Frontiers in oncology 2012;2():168.
2012: Nigel J Pyne; Joanne Edwards; Keng Gat Lim; Jaclyn Long; Francesca Tonelli; Susan Pyne
Targeting sphingosine kinase 1 in cancer.
Advances in biological regulation 2012;52(1):31-8.
2011: Susan Pyne; Nigel J Pyne
Translational aspects of sphingosine 1-phosphate biology.
Trends in molecular medicine 2011;17(8):463-72.
2011: Keng G Lim; Francesca Tonelli; Zaiguo Li; Xuequan Lu; Robert Bittman; Susan Pyne; Nigel J Pyne
FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.
The Journal of biological chemistry 2011;286(21):18633-40.
2011: Nigel J Pyne; Susan Pyne
Selectivity and specificity of sphingosine 1-phosphate receptor ligands: "off-targets" or complex pharmacology?
Frontiers in pharmacology 2011;2():26.
2010: Carolyn Loveridge; Francesca Tonelli; Tamara Leclercq; Keng Gat Lim; Jaclyn S Long; Evgeny Berdyshev; Rothwelle J Tate; Viswanathan Natarajan; Stuart M Pitson; Nigel J Pyne; Susan Pyne
The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.
The Journal of biological chemistry 2010;285(50):38841-52.
2010: Jaclyn S Long; Yuko Fujiwara; Joanne Edwards; Claire L Tannahill; Gabor Tigyi; Susan Pyne; Nigel J Pyne
Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.
The Journal of biological chemistry 2010;285(46):35957-66.
2010: Carol Watson; Jaclyn S Long; Clare Orange; Claire L Tannahill; Elizabeth Mallon; Liane M McGlynn; Susan Pyne; Nigel J Pyne; Joanne Edwards
High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients.
The American journal of pathology 2010;177(5):2205-15.
2010: Francesca Tonelli; Keng Gat Lim; Carolyn Loveridge; Jaclyn Long; Stuart M Pitson; Gabor Tigyi; Robert Bittman; Susan Pyne; Nigel J Pyne
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Cellular signalling 2010;22(10):1536-42.
2010: Jaclyn S Long; Joanne Edwards; Carol Watson; Sian Tovey; Kirsty M Mair; Rachel Schiff; Viswanathan Natarajan; Nigel J Pyne; Susan Pyne
Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells.
Molecular and cellular biology 2010;30(15):3827-41.
2010: Nigel J Pyne; Susan Pyne
Sphingosine 1-phosphate and cancer.
Nature reviews. Cancer 2010;10(7):489-503.
2010: Robert A McDonald; Susan Pyne; Nigel J Pyne; Anne Grant; Cherry Wainwright; Roger M Wadsworth
The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia.
British journal of pharmacology 2010;159(3):543-53.
2010: Brian Furman; Wee Kiat Ong; Nigel J Pyne
Cyclic AMP signaling in pancreatic islets.
Advances in experimental medicine and biology 2010;654():281-304.
2009: Alayna Rodgers; David Mormeneo; Jaclyn S Long; Antonio Delgado; Nigel J Pyne; Susan Pyne
Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells.
Stem cells and development 2009;18(9):1319-30.
2009: Wee Kiat Ong; F M Gribble; F Reimann; M J Lynch; Miles D Houslay; G S Baillie; Brian L Furman; Nigel J Pyne
The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release.
British journal of pharmacology 2009;157(4):633-44.
2009: Laura Gillies; Sue Chin Lee; Jaclyn S Long; Nicholas T Ktistakis; Nigel J Pyne; Susan Pyne
The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division.
Cellular signalling 2009;21(5):675-84.
2009: Nigel J Pyne; Jaclyn S Long; Sue Chin Lee; Carolyn Loveridge; Laura Gillies; Susan Pyne
New aspects of sphingosine 1-phosphate signaling in mammalian cells.
Advances in enzyme regulation 2009;49(1):214-21.
2009: Susan Pyne; Sue Chin Lee; Jaclyn Long; Nigel J Pyne
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease.
Cellular signalling 2009;21(1):14-21.
2008: Nigel J Pyne; Susan Pyne
Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination.
Biochimica et biophysica acta 2008;1781(9):467-76.
2008: Irina A Gorshkova; Donghong He; Evgeny Berdyshev; Peter Usatuyk; Michael Burns; Satish Kalari; Yutong Zhao; Srikanth Pendyala; Joe G. N. Garcia; Nigel J Pyne; David N Brindley; Viswanathan Natarajan
Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1.
The Journal of biological chemistry 2008;283(17):11794-806.
2008: Jaclyn S Long; Nigel J Pyne; Susan Pyne
Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.
The Biochemical journal 2008;411(2):371-7.
2007: Nigel J Pyne; Catherine M Waters; Jaclyn S Long; Noreen A Moughal; Gabor Tigyi; Susan Pyne
Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells.
Advances in enzyme regulation 2007;47():271-80.
2006: Brian L Furman; Nigel J Pyne
Modulation of cyclic nucleotides and cyclic nucleotide phosphodiesterases in pancreatic islet beta-cells and intestinal L-cells as targets for treating diabetes mellitus.
Current opinion in investigational drugs (London, England : 2000) 2006;7(10):898-905.
2006: Noreen A Moughal; Catherine M Waters; William J Valentine; Michelle Connell; Jill C Richardson; Gabor Tigyi; Susan Pyne; Nigel J Pyne
Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells.
Journal of neurochemistry 2006;98(6):1920-9.
2006: Catherine M Waters; Bahman Saatian; Noreen A Moughal; Yutong Zhao; Gabor Tigyi; Viswanathan Natarajan; Susan Pyne; Nigel J Pyne
Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells.
The Biochemical journal 2006;398(1):55-62.
2006: Yutong Zhao; Donghong He; Bahman Saatian; Tonya Watkins; Ernst Wm Spannhake; Nigel J Pyne; Viswanathan Natarajan
Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases.
The Journal of biological chemistry 2006;281(28):19501-11.
2006: Jaclyn S Long; Viswanathan Natarajan; Gabor Tigyi; Susan Pyne; Nigel J Pyne
The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor.
Prostaglandins & other lipid mediators 2006;80(1-2):74-80.
2006: Balwinder Sambi; Melinda D Hains; Catherine M Waters; Michelle Connell; Francis S Willard; Adam Jordan Kimple; Susan Pyne; David Siderovski; Nigel J Pyne
The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells.
Cellular signalling 2006;18(7):971-81.
2006: Maqsood Ahmad; Jaclyn S Long; Nigel J Pyne; Susan Pyne
The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells.
Prostaglandins & other lipid mediators 2006;79(3-4):278-86.
2006: Jaclyn S Long; Kazuaki Yokoyama; Gabor Tigyi; Nigel J Pyne; Susan Pyne
Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration.
The Biochemical journal 2006;394(Pt 2):495-500.
2006: Catherine M Waters; Jaclyn Long; Irina A Gorshkova; Yuko Fujiwara; Michelle Connell; Kristen E Belmonte; Gabor Tigyi; Viswanathan Natarajan; Susan Pyne; Nigel J Pyne
Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):509-11.
2005: Susan Pyne; Jaclyn S Long; Nicholas T Ktistakis; Nigel J Pyne
Lipid phosphate phosphatases and lipid phosphate signalling.
Biochemical Society transactions 2005;33(Pt 6):1370-4.
2005: Jaclyn Long; Peter I Darroch; Kah Fei Wan; Kok-Choi Kong; Nicholas T Ktistakis; Nigel J Pyne; Susan Pyne
Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools.
The Biochemical journal 2005;391(Pt 1):25-32.
2005: Catherine M Waters; Michelle Connell; Susan Pyne; Nigel J Pyne
c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells.
Cellular signalling 2005;17(2):263-77.
2004: Brian L Furman; Nigel J Pyne; Peter Flatt; Finbarr O'Harte
Targeting beta-cell cyclic 3'5' adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review.
The Journal of pharmacy and pharmacology 2004;56(12):1477-92.
2004: Catherine Waters; Susan Pyne; Nigel J Pyne
The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction.
Seminars in cell & developmental biology 2004;15(3):309-23.
2004: Nigel J Pyne; Catherine Waters; Noreen A Moughal; Balwinder Sambi; Michelle Connell; Susan Pyne
Experimental systems for studying the role of G-protein-coupled receptors in receptor tyrosine kinase signal transduction.
Methods in enzymology 2004;390():451-75.
2004: Noreen A Moughal; Catherine Waters; Balwinder Sambi; Susan Pyne; Nigel J Pyne
Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells.
Cellular signalling 2004;16(1):127-36.
2003: Nigel J Pyne; Catherine Waters; Noreen A Moughal; Balwinder Sambi; Susan Pyne
Receptor tyrosine kinase-GPCR signal complexes.
Biochemical Society transactions 2003;31(Pt 6):1220-5.
2003: Nigel J Pyne; Brian L Furman
Cyclic nucleotide phosphodiesterases in pancreatic islets.
Diabetologia 2003;46(9):1179-89.
2003: Kah Fei Wan; Balwinder Sambi; Rothwelle Tate; Catherine Waters; Nigel J Pyne
The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor.
The Journal of biological chemistry 2003;278(20):18658-63.
2003: Fiona Murray; Margaret R MacLean; Nigel J Pyne
An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen-activated protein kinase pathway in animal and cellular models of pulmonary hypertension.
British journal of pharmacology 2003;138(7):1313-9.
2003: Mhairi J Frame; Rothwelle Tate; David R Adams; Keith M Morgan; Miles D Houslay; Peter Vandenabeele; Nigel J Pyne
Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1).
European journal of biochemistry / FEBS 2003;270(5):962-70.
2003: Catherine Waters; Balwinder Sambi; Kok-Choi Kong; Dawn Thompson; Stuart M Pitson; Susan Pyne; Nigel J Pyne
Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells.
The Journal of biological chemistry 2003;278(8):6282-90.
2003: Joseph D Bruton; Raf Lemmens; Chun-Liang Shi; Solveig Persson-Sjögren; Håkan Westerblad; Masroor Ahmed; Nigel J Pyne; Mhairi Frame; Brian L Furman; Md Shahidul Islam
Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):301-3.
2002: Fiona Murray; Margaret R MacLean; Nigel J Pyne
Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension.
British journal of pharmacology 2002;137(8):1187-94.
2002: Susan Pyne; Nigel J Pyne
Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors.
Biochimica et biophysica acta 2002;1582(1-3):121-31.
2002: Rothwelle J Tate; Vadim Y Arshavsky; Nigel J Pyne
The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcripts.
Genomics 2002;79(4):582-6.
2002: Liqun Zhang; James R Parratt; Graham H Beastall; Nigel J Pyne; Brian L Furman
Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism.
European journal of pharmacology 2002;435(2-3):269-76.
2001: Kah Fei Wan; Balwinder Sambi; Mhairi J Frame; Rothwelle Tate; Nigel J Pyne
The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells.
The Journal of biological chemistry 2001;276(41):37802-8.
2001: Mhairi J Frame; Kah Fei Wan; Rothwelle Tate; Peter Vandenabeele; Nigel J Pyne
The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3.
Cellular signalling 2001;13(10):735-41.
2001: Lorraine M Work; Allan R McPhaden; Nigel J Pyne; Susan Pyne; Roger M Wadsworth; Cherry Wainwright
Short-term local delivery of an inhibitor of Ras farnesyltransferase prevents neointima formation in vivo after porcine coronary balloon angioplasty.
Circulation 2001;104(13):1538-43.
2001: F Alderton; Balwinder Sambi; Rothwelle Tate; Nigel J Pyne; Susan Pyne
Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells.
British journal of pharmacology 2001;134(1):6-9.
2001: F Alderton; S Rakhit; Kok-Choi Kong; T Palmer; Balwinder Sambi; Susan Pyne; Nigel J Pyne
Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.
The Journal of biological chemistry 2001;276(30):28578-85.
2001: S Rakhit; Susan Pyne; Nigel J Pyne
Nerve growth factor stimulation of p42/p44 mitogen-activated protein kinase in PC12 cells: role of G(i/o), G protein-coupled receptor kinase 2, beta-arrestin I, and endocytic processing.
Molecular pharmacology 2001;60(1):63-70.
2001: F Alderton; Peter I Darroch; Balwinder Sambi; A McKie; I S Ahmed; Nigel J Pyne; Susan Pyne
G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells.
The Journal of biological chemistry 2001;276(16):13452-60.
2000: Ann-Marie Conway; Nigel J Pyne; Susan Pyne
Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells.
Cellular signalling 2000;12(11-12):737-43.
2000: Susan Pyne; Nigel J Pyne
Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.
Pharmacology & therapeutics 2000;88(2):115-31.
2000: M Ahmad; Peter Flatt; Brian L Furman; Nigel J Pyne
The role of the cyclic GMP-inhibited cyclic AMP-specific phosphodiesterase (PDE3) in regulating clonal BRIN-BD11 insulin secreting cell survival.
Cellular signalling 2000;12(8):541-8.
2000: S Rakhit; Susan Pyne; Nigel J Pyne
The platelet-derived growth factor receptor stimulation of p42/p44 mitogen-activated protein kinase in airway smooth muscle involves a G-protein-mediated tyrosine phosphorylation of Gab1.
Molecular pharmacology 2000;58(2):413-20.
2000: Susan Pyne; Nigel J Pyne
Sphingosine 1-phosphate signalling in mammalian cells.
The Biochemical journal 2000;349(Pt 2):385-402.
2000: M Ahmad; Y H Abdel-Wahab; Rothwelle Tate; Peter Flatt; Nigel J Pyne; Brian L Furman
Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN-BD11.
British journal of pharmacology 2000;129(6):1228-34.
1999: Susan Pyne; S Rakhit; Ann-Marie Conway; A McKie; Peter I Darroch; Rothwelle Tate; Nigel J Pyne
Extracellular actions of sphingosine I-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis.
Biochemical Society transactions 1999;27(4):404-9.
1999: DG Tolan; Ann-Marie Conway; S Rakhit; Nigel J Pyne; Susan Pyne
Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model.
Cellular signalling 1999;11(5):349-54.
1999: S Rakhit; Ann-Marie Conway; Rothwelle Tate; T Bower; Nigel J Pyne; Susan Pyne
Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase.
The Biochemical journal 1999;338 ( Pt 3)():643-9.
1999: Ann-Marie Conway; S Rakhit; Susan Pyne; Nigel J Pyne
Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase.
The Biochemical journal 1999;337 ( Pt 2)():171-7.
1998: Nigel J Pyne; Susan Pyne
PDGF-stimulated cyclic AMP formation in airway smooth muscle: assessment of the roles of MAP kinase, cytosolic phospholipase A2, and arachidonate metabolites.
Cellular signalling 1998;10(5):363-9.
1998: Rothwelle J Tate; A Lochhead; H Brzeski; Vadim Y Arshavsky; Nigel J Pyne
The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung.
Cell biochemistry and biophysics 1998;29(1-2):133-44.
1997: Nigel J Pyne; DG Tolan; Susan Pyne
Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle.
The Biochemical journal 1997;328 ( Pt 2)():689-94.
1997: Ann-Marie Conway; Nigel J Pyne; Susan Pyne
Sphingosine 1-phosphate activation of MAP kinase--involvement of PI 3-kinase and protein kinase C.
Biochemical Society transactions 1997;25(4):S585.
1997: DG Tolan; Ann-Marie Conway; Nigel J Pyne; Susan Pyne
Sphingosine prevents diacylglycerol signaling to mitogen-activated protein kinase in airway smooth muscle.
The American journal of physiology 1997;273(3 Pt 1):C928-36.
1997: A Lochhead; E Nekrasova; Vadim Y Arshavsky; Nigel J Pyne
The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase.
The Journal of biological chemistry 1997;272(29):18397-403.
1997: Nigel J Pyne; Susan Pyne
Platelet-derived growth factor activates a mammalian Ste20 coupled mitogen-activated protein kinase in airway smooth muscle.
Cellular signalling 1997;9(3-4):311-7.
1997: Susan Pyne; DG Tolan; Ann-Marie Conway; Nigel J Pyne
Sphingolipids as differential regulators of cellular signalling processes.
Biochemical Society transactions 1997;25(2):549-56.
1997: M El-Metwally; R Shafiee-Nick; Nigel J Pyne; Brian L Furman
The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat.
European journal of pharmacology 1997;324(2-3):227-32.
1996: Nigel J Pyne; V Arshavsky; A Lochhead
cGMP signal termination.
Biochemical Society transactions 1996;24(4):1019-22.
1996: DG Tolan; Ann-Marie Conway; L Steele; Susan Pyne; Nigel J Pyne
The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle.
British journal of pharmacology 1996;119(2):185-6.
1996: S Wilson; W Song; K Karoly; Tanya Ravingerova; A Vegh; J Papp; S Tomisawa; James R Parratt; Nigel J Pyne
Delayed cardioprotection is associated with the sub-cellular relocalisation of ventricular protein kinase C epsilon, but not p42/44MAPK.
Molecular and cellular biochemistry 1996;160-161():225-30.
1996: Susan Pyne; J Chapman; L Steele; Nigel J Pyne
Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle.
European journal of biochemistry / FEBS 1996;237(3):819-26.
1996: Susan Pyne; Nigel J Pyne
The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle.
The Biochemical journal 1996;315 ( Pt 3)():917-23.
1995: Susan Pyne; Nigel J Pyne
Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C.
The Biochemical journal 1995;311 ( Pt 2)():637-42.
1995: R Shafiee-Nick; Nigel J Pyne; Brian L Furman
Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity.
British journal of pharmacology 1995;115(8):1486-92.
1995: T Ravingerová; Nigel J Pyne; James R Parratt
Ischaemic preconditioning in the rat heart: the role of G-proteins and adrenergic stimulation.
Molecular and cellular biochemistry 1995;147(1-2):123-8.
1995: Nigel J Pyne; P Stevens; N Moughal; Susan Pyne
PKC-dependent activation of the type II adenylate cyclase in airway smooth muscle limits the bradykinin-stimulated ERK-2 pathway.
Biochemical Society transactions 1995;23(2):200S.
1995: Susan Pyne; Nigel J Pyne
Phospholipase D regulation involves extracellular calcium as a conditional requirement for subsequent stimulation by protein kinase C.
Biochemical Society transactions 1995;23(2):199S.
1995: DG Tolan; Nigel J Pyne; Susan Pyne
Phosphatidic acid phosphohydrolase in guinea-pig airway smooth muscle.
Biochemical Society transactions 1995;23(2):198S.
1995: N Moughal; P A Stevens; D Kong; Susan Pyne; Nigel J Pyne
Adenylate cyclase, cyclic AMP and extracellular-signal-regulated kinase-2 in airway smooth muscle: modulation by protein kinase C and growth serum.
The Biochemical journal 1995;306 ( Pt 3)():723-6.
1995: P A Stevens; Nigel J Pyne
The inhibition of adenylyl cyclase activity in isolated lung membranes by muscarinic and alpha-adrenoceptor agonists: role of G-protein alpha and beta gamma sub-units.
Cellular signalling 1995;7(2):157-63.
1994: Nigel J Pyne; N Moughal; P A Stevens; DG Tolan; Susan Pyne
Protein kinase C-dependent cyclic AMP formation in airway smooth muscle: the role of type II adenylate cyclase and the blockade of extracellular-signal-regulated kinase-2 (ERK-2) activation.
The Biochemical journal 1994;304 ( Pt 2)():611-6.
1994: F Burns; P A Stevens; Nigel J Pyne
The identification of apparently novel cyclic AMP and cyclic GMP phosphodiesterase activities in guinea-pig tracheal smooth muscle.
British journal of pharmacology 1994;113(1):3-4.
1994: Susan Pyne; Nigel J Pyne
Bradykinin-stimulated phosphatidate and 1,2-diacylglycerol accumulation in guinea-pig airway smooth muscle: evidence for regulation 'down-stream' of phospholipases.
Cellular signalling 1994;6(3):269-77.
1994: P A Stevens; Susan Pyne; M Grady; Nigel J Pyne
Bradykinin-dependent activation of adenylate cyclase activity and cyclic AMP accumulation in tracheal smooth muscle occurs via protein kinase C-dependent and -independent pathways.
The Biochemical journal 1994;297 ( Pt 1)():233-9.
1993: Susan Pyne; Nigel J Pyne
Differential effects of B2 receptor antagonists upon bradykinin-stimulated phospholipase C and D in guinea-pig cultured tracheal smooth muscle.
British journal of pharmacology 1993;110(1):477-81.
1993: Nigel J Pyne; Susan Pyne
Cellular signal pathways in tracheal smooth muscle.
Cellular signalling 1993;5(4):401-9.
1993: M Grady; P A Stevens; Susan Pyne; Nigel J Pyne
Adenylyl cyclase in lung from hypersensitive guinea pig displays increased responsiveness to guanine nucleotides and isoprenaline: the role of the G proteins Gs and Gi.
Biochimica et biophysica acta 1993;1176(3):313-20.
1993: Susan Pyne; Nigel J Pyne
Bradykinin stimulates phospholipase D in primary cultures of guinea-pig tracheal smooth muscle.
Biochemical pharmacology 1993;45(3):593-603.
1993: Nigel J Pyne; F Burns
Lung phosphodiesterase isoenzymes.
Agents and actions. Supplements 1993;43():35-49.
1992: F Burns; Nigel J Pyne
Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase: modulation of non-catalytic binding sites.
Biochemical and biophysical research communications 1992;189(3):1389-96.
1992: Nigel J Pyne; M W Grady; D Shehnaz; P A Stevens; Susan Pyne; I W Rodger
Muscarinic blockade of beta-adrenoceptor-stimulated adenylyl cyclase: the role of stimulatory and inhibitory guanine-nucleotide binding regulatory proteins (Gs and Gi).
British journal of pharmacology 1992;107(3):881-7.
1992: Nigel J Pyne; M Freissmuth; Susan Pyne
Phosphorylation of the recombinant spliced variants of the alpha-sub-unit of the stimulatory guanine-nucleotide binding regulatory protein (Gs) by the catalytic sub-unit of protein kinase A.
Biochemical and biophysical research communications 1992;186(2):1081-6.
1992: Nigel J Pyne; M Freissmuth; S Palmer
Phosphorylation of the spliced variant forms of the recombinant stimulatory guanine-nucleotide-binding regulatory protein (Gs alpha) by protein kinase C.
The Biochemical journal 1992;285 ( Pt 1)():333-8.
1992: F Burns; I W Rodger; Nigel J Pyne
The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung.
The Biochemical journal 1992;283 ( Pt 2)():487-91.
1991: Nigel J Pyne; D Shehnaz; I W Rodger
Phorbol esters trigger the inactivation of the inhibitory quanine-nucleotide binding regulatory protein (Gi) in airway smooth muscle.
Biochemical Society transactions 1991;19(2):75S.