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Yun Qiu

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Douglas E Linn; Alan Alfano; Hegang Chen; Mingyuan Chen; Dhanraj Deshmukh; Wei Li; Hermela Shimelis; Xin Wang; Yingqiu Xie; Kexin Xu; Xi Yang; Yun Qiu
Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.
Xi Yang; Alan Alfano; Angela Brodie; Hegang Chen; Mingyuan Chen; Zhiyong Guo; Wei Li; Hermela Shimelis; Feng Sun; Timothy D Veenstra; Zhen Xiao; Yun Qiu
Novel membrane-associated androgen receptor splice variant potentiates proliferative and survival responses in prostate cancer cells.
Anilchandra Attaluri; Wei Li; Ronghui Ma; Yun Qiu; Liang Zhu
Nanoparticle distribution and temperature elevations in prostatic tumours in mice during magnetic nanoparticle hyperthermia.

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All Publications

2012: Douglas E Linn; Alan Alfano; Hegang Chen; Mingyuan Chen; Dhanraj Deshmukh; Wei Li; Hermela Shimelis; Xin Wang; Yingqiu Xie; Kexin Xu; Xi Yang; Yun Qiu
Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.
The Journal of biological chemistry 2012;287(27):22959-68.
2011: Xi Yang; Alan Alfano; Angela Brodie; Hegang Chen; Mingyuan Chen; Zhiyong Guo; Wei Li; Hermela Shimelis; Feng Sun; Timothy D Veenstra; Zhen Xiao; Yun Qiu
Novel membrane-associated androgen receptor splice variant potentiates proliferative and survival responses in prostate cancer cells.
The Journal of biological chemistry 2011;286(41):36152-60.
2011: Anilchandra Attaluri; Wei Li; Ronghui Ma; Yun Qiu; Liang Zhu
Nanoparticle distribution and temperature elevations in prostatic tumours in mice during magnetic nanoparticle hyperthermia.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2011;27(5):491-502.
2011: Zhiyong Guo; Yun Qiu
A new trick of an old molecule: androgen receptor splice variants taking the stage?!
International journal of biological sciences 2011;7(6):815-22.
2011: Shengjie Guo; Feng Sun; Zhiyong Guo; Wei Li; Alan Alfano; Hegang Chen; Clara E Magyar; Jiaoti Huang; Toby C Chai; Shaopeng Qiu; Yun Qiu
Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy.
PloS one 2011;6(3):e17778.
2010: Douglas E Linn; Feng Sun; Yingqiu Xie; Xi Yang; Angelika Burger; Hege Chen; Hegang Chen; Saranya Chumsri; Richeng Jiang; Yun Qiu
A Role for OCT4 in Tumor Initiation of Drug-Resistant Prostate Cancer Cells.
Genes & cancer 2010;1(9):908-16.
2010: Yingqiu Xie; Mehmet Burcu; Douglas E Linn; Yun Qiu; Maria R Baer
Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression.
Molecular pharmacology 2010;78(2):310-8.
2010: Bojie Dai; Hege Chen; Shengjie Guo; Xi Yang; Douglas E Linn; Feng Sun; Wei Li; Zhiyong Guo; Kexin Xu; Oekyung Kim; Xiangtian Kong; Jonathan Melamed; Shaopeng Qiu; Hegang Chen; Yun Qiu
Compensatory upregulation of tyrosine kinase Etk/BMX in response to androgen deprivation promotes castration-resistant growth of prostate cancer cells.
Cancer research 2010;70(13):5587-96.
2010: Irit Cohen; Myriam Maoz; Hagit Turm; Sorina Grisaru-Granovsky; Bella Maly; Beatrice Uziely; Einat Weiss; Rinat Abramovitch; Eithan Gross; Oded Barzilay; Yun Qiu; Rachel Bar-Shavit
Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: signaling partners, hierarchy and physiological significance.
PloS one 2010;5(6):e11135.
2009: Jean-Ju Chung; Yukari Okamoto; Brian Coblitz; Min Li; Yun Qiu; Sojin Shikano
PI3K/Akt signalling-mediated protein surface expression sensed by 14-3-3 interacting motif.
The FEBS journal 2009;276(19):5547-58.
2009: Kexin Xu; Hermela Shimelis; Douglas E Linn; Richeng Jiang; Xi Yang; Feng Sun; Zhiyong Guo; Hegang Chen; Wei Li; He-Ge Chen; Xiangtian Kong; Jonathan Melamed; Shengyun Fang; Zhen Xiao; Timothy D Veenstra; Yun Qiu
Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination.
Cancer cell 2009;15(4):270-82.
2009: Zhiyong Guo; Xi Yang; Feng Sun; Richeng Jiang; Douglas E Linn; Hegang Chen; He-Ge Chen; Xiangtian Kong; Jonathan Melamed; Clifford G Tepper; Hsing-Jien Kung; Angela Brodie; Joanne Edwards; Yun Qiu
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.
Cancer research 2009;69(6):2305-13.
2009: Yung-Tuen Chiu; Hui-Ying Han; Steve C L Leung; Hiu-Fung Yuen; Chee-Wai Chau; Zhiyong Guo; Yun Qiu; Kwok Wah Chan; Xianghong Wang; Yong-Chuan Wong; Ming-Tat Ling
CDC25A functions as a novel Ar corepressor in prostate cancer cells.
Journal of molecular biology 2009;385(2):446-56.
2008: Yingqiu Xie; Kexin Xu; Douglas E Linn; Xi Yang; Zhiyong Guo; Hermela Shimelis; Takeo Nakanishi; Douglas Ross; Hegang Chen; Ladan Fazli; Martin E Gleave; Yun Qiu
The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.
The Journal of biological chemistry 2008;283(6):3349-56.
2007: Zhaomin Zhong; Bo Wan; Yun Qiu; Jun Ni; Wenwen Tang; Xinya Chen; Yun Yang; Suqin Shen; Ying Wang; Meirong Bai; Qingyu Lang; Long Yu
Identification of a novel human zinc finger gene, ZNF438, with transcription inhibition activity.
Journal of biochemistry and molecular biology 2007;40(4):517-24.
2007: Sujit S Nair; Zhiyong Guo; Judith M Mueller; Shahriar Koochekpour; Yun Qiu; Rajeshwar Tekmal; Roland Schüle; Hsing-Jien Kung; Rakesh Kumar; Ratna K Vadlamudi
Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2.
Molecular endocrinology (Baltimore, Md.) 2007;21(3):613-24.
2006: Zhiyong Guo; Bojie Dai; Tianyun Jiang; Kexin Xu; Yingqiu Xie; Oekyung Kim; Issa Nesheiwat; Xiangtian Kong; Jonathan Melamed; Venkatesh D Handratta; Vincent Njar; Angela Brodie; Li-Rong Yu; Timothy D Veenstra; Hegang Chen; Yun Qiu
Regulation of androgen receptor activity by tyrosine phosphorylation.
Cancer cell 2006;10(4):309-19.
2006: Bojie Dai; Oekyung Kim; Yingqiu Xie; Zhiyong Guo; Kexin Xu; Bin Wang; Xiangtian Kong; Jonathan Melamed; Hegang Chen; Charles J Bieberich; Alexander D Borowsky; Hsing-Jien Kung; Guo Wei; Michael C Ostrowski; Angela Brodie; Yun Qiu
Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse.
Cancer research 2006;66(16):8058-64.
2006: Luciana Macedo; Zhiyong Guo; Syreeta Latatia Tilghman; Gauri Sabnis; Yun Qiu; Angela Brodie
Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole.
Cancer research 2006;66(15):7775-82.
2006: Huiling Yang; Yu-Ye Wen; Ruiying Zhao; Yu-Li Lin; Keith Fournier; Heng-Yin Yang; Yun Qiu; Jose Diaz; Christine Laronga; Mong-Hong Lee
DNA damage-induced protein 14-3-3 sigma inhibits protein kinase B/Akt activation and suppresses Akt-activated cancer.
Cancer research 2006;66(6):3096-105.
2006: Yingqiu Xie; K Xu; Bojie Dai; Zhiyong Guo; Tianyun Jiang; Hegang Chen; Yun Qiu
The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs.
Oncogene 2006;25(1):70-8.
2005: Cindy H Chau; Carlos A Clavijo; Hong-Tao Deng; Qunzhou Zhang; Kwang-Jin Kim; Yun Qiu; Anh D Le; David K Ann
Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems.
American journal of physiology. Cell physiology 2005;289(2):C444-54.
2005: Venkatesh D Handratta; Tadas S Vasaitis; Vincent Njar; Lalji Gediya; Ritesh Kataria; Pankaj Chopra; Donnell Newman; Rena Farquhar; Zhiyong Guo; Yun Qiu; Angela Brodie
Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.
Journal of medicinal chemistry 2005;48(8):2972-84.
2004: Tianyun Jiang; Zhiyong Guo; Bojie Dai; Miyoung Kang; David K Ann; Hsing-Jien Kung; Yun Qiu
Bi-directional regulation between tyrosine kinase Etk/BMX and tumor suppressor p53 in response to DNA damage.
The Journal of biological chemistry 2004;279(48):50181-9.
2004: Oekyung Kim; Tianyun Jiang; Yingqiu Xie; Zhiyong Guo; Hegang Chen; Yun Qiu
Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells.
Oncogene 2004;23(10):1838-44.
2003: Tianyun Jiang; Yun Qiu
Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.
The Journal of biological chemistry 2003;278(18):15789-93.
2002: Liang Xia; Dan Robinson; Ai-Hong Ma; Hua-Chien Chen; Frederick Wu; Yun Qiu; Hsing-Jien Kung
Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells.
The Journal of biological chemistry 2002;277(38):35422-33.
2002: Oekyung Kim; Jianbo Yang; Yun Qiu
Selective activation of small GTPase RhoA by tyrosine kinase Etk through its pleckstrin homology domain.
The Journal of biological chemistry 2002;277(33):30066-71.
2002: Jianbo Yang; Oekyung Kim; Jie Wu; Yun Qiu
Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking.
The Journal of biological chemistry 2002;277(33):30219-26.
2001: L F Lee; Jun-Lin Guan; Yun Qiu; Hsing-Jien Kung
Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase.
Molecular and cellular biology 2001;21(24):8385-97.
2001: R Chen; Oekyung Kim; Jianbo Yang; K Sato; K M Eisenmann; J McCarthy; Hegang Chen; Yun Qiu
Regulation of Akt/PKB activation by tyrosine phosphorylation.
The Journal of biological chemistry 2001;276(34):31858-62.
2001: R Chen; O Kim; Min Li; X Xiong; Jun-Lin Guan; Hsing-Jien Kung; Hegang Chen; Y Shimizu; Yun Qiu
Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.
Nature cell biology 2001;3(5):439-44.
2001: Melody L Woods; WJ Kivens; M A Adelsman; Yun Qiu; A August; Yoji Shimizu
A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor.
The EMBO journal 2001;20(6):1232-44.
2000: Yun Qiu; Hsing-Jien Kung
Signaling network of the Btk family kinases.
Oncogene 2000;19(49):5651-61.
2000: Yuh-Tyng Tsai; Yueh-Hsing Su; S S Fang; T N Huang; Yun Qiu; Yuh-Shan Jou; Hsiu-Ming Shih; Hsing-Jien Kung; Ruey-Hwa Chen
Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.
Molecular and cellular biology 2000;20(6):2043-54.
1999: Liang-yan Xue; Yun Qiu; J He; Hsing-Jien Kung; Nancy L Oleinick
Etk/Bmx, a PH-domain containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by photodynamic therapy or thapsigargin.
Oncogene 1999;18(22):3391-8.
1998: Yun Qiu; D Robinson; T G Pretlow; Hsing-Jien Kung
Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3644-9.
1995: Yun Qiu; M Nemeroff; Robert M Krug
The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing.
RNA (New York, N.Y.) 1995;1(3):304-16.
1994: Yun Qiu; Robert M Krug
The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A).
Journal of virology 1994;68(4):2425-32.
1992: F V Alonso-Caplen; M E Nemeroff; Yun Qiu; Robert M Krug
Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA.
Genes & development 1992;6(2):255-67.