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Wilma Quaglia
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37
Pigini, Maria
32
Giannella, Mario
31
Piergentili, Alessandro
20
Brasili, Livio
19
Melchiorre, Carlo
14
Gentili, Francesco
13
Marucci, Gabriella
12
Giardinà, Dario
9
Carrieri, Antonio
9
Tayebati, Seyed Khosrow
8
Dontenwill, Monique
7
Bousquet, Pascal
7
Angeli, Piero
6
Ghelfi, Francesca
6
Leonardi, Amedeo
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All Publications
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2009: Piergentili Alessandro; Quaglia Wilma; Del Bello Fabio; Giannella Mario; Pigini Maria; Barocelli Elisabetta; Bertoni Simona; Matucci Rosanna; Nesi Marta; Bruni Bruno; Di Vaira Massimo
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.
Bioorganic & medicinal chemistry 2009;17(24):8174-85.
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2008: Gentili Francesco; Cardinaletti Claudia; Vesprini Cristian; Ghelfi Francesca; Farande Aniket; Giannella Mario; Piergentili Alessandro; Quaglia Wilma; Mattioli Laura; Perfumi Marina; Hudson Alan; Pigini Maria
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions.
Journal of medicinal chemistry 2008;51(16):5130-4.
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2008: Gentili Francesco; Cardinaletti Claudia; Vesprini Cristian; Carrieri Antonio; Ghelfi Francesca; Farande Aniket; Giannella Mario; Piergentili Alessandro; Quaglia Wilma; Laurila Jonne M; Huhtinen Anna; Scheinin Mika; Pigini Maria
Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior.
Journal of medicinal chemistry 2008;51(14):4289-99.
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2008: Piergentili Alessandro; Quaglia Wilma; Giannella Mario; Del Bello Fabio; Buccioni Michela; Nesi Marta; Matucci Rosanna
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide.
Bioorganic & medicinal chemistry letters 2008;18(2):614-8.
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2007: Crassous Pierre-Antoine; Cardinaletti Claudia; Carrieri Antonio; Bruni Bruno; Di Vaira Massimo; Gentili Francesco; Ghelfi Francesca; Giannella Mario; Paris Hervé; Piergentili Alessandro; Quaglia Wilma; Schaak Stéphane; Vesprini Cristian; Pigini Maria
Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist.
Journal of medicinal chemistry 2007;50(16):3964-8.
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2007: Piergentili Alessandro; Quaglia Wilma; Giannella Mario; Del Bello Fabio; Bruni Bruno; Buccioni Michela; Carrieri Antonio; Ciattini Samuele
Dioxane and oxathiane nuclei: suitable substructures for muscarinic agonists.
Bioorganic & medicinal chemistry 2007;15(2):886-96.
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2005: Quaglia Wilma; Santoni Giorgio; Pigini Maria; Piergentili Alessandro; Gentili Francesco; Buccioni Michela; Mosca Michela; Lucciarini Roberta; Amantini Consuelo; Nabissi Massimo Ivan; Ballarini Patrizia; Poggesi Elena; Leonardi Amedeo; Giannella Mario
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4-chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation.
Journal of medicinal chemistry 2005;48(24):7750-63.
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2004: Gentili Francesco; Ghelfi Francesca; Giannella Mario; Piergentili Alessandro; Pigini Maria; Quaglia Wilma; Vesprini Cristian; Crassous Pierre-Antoine; Paris Hervé; Carrieri Antonio
alpha 2-adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha 2C-subtype.
Journal of medicinal chemistry 2004;47(25):6160-73.
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2004: Dupuy L; Urosevic D; Greney H; Quaglia W; Pigini M; Brasili L; Dontenwill M; Bousquet P
I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells.
Cell death and differentiation 2004;11(9):1049-52.
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2003: Piergentili Alessandro; Gentili Francesco; Ghelfi Francesca; Marucci Gabriella; Pigini Maria; Quaglia Wilma; Giannella Mario
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine.
Bioorganic & medicinal chemistry 2003;11(18):3901-11.
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2003: Gentili Francesco; Bousquet Pascal; Brasili Livio; Dontenwill Monique; Feldman Josiane; Ghelfi Francesca; Giannella Mario; Piergentili Alessandro; Quaglia Wilma; Pigini Maria
Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues.
Journal of medicinal chemistry 2003;46(11):2169-76.
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2003: Ferretti G; Dukat M; Giannella M; Piergentili A; Pigini M; Quaglia W; Damaj M I; Martin B R; Glennon R A
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors.
Bioorganic & medicinal chemistry letters 2003;13(4):733-5.
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2002: Ferretti G; Dukat M; Giannella M; Piergentili A; Pigini M; Quaglia W; Damaj M I; Martin B R; Glennon R A
Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding.
Journal of medicinal chemistry 2002;45(21):4724-31.
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2002: Quaglia Wilma; Pigini Maria; Piergentili Alessandro; Giannella Mario; Gentili Francesco; Marucci Gabriella; Carrieri Antonio; Carotti Angelo; Poggesi Elena; Leonardi Amedeo; Melchiorre Carlo
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.
Journal of medicinal chemistry 2002;45(8):1633-43.
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2002: Angeli Piero; Marucci Gabriella; Buccioni Michela; Piergentili Alessandro; Giannella Mario; Quaglia Wilma; Pigini Maria; Cantalamessa Franco; Nasuti Cinzia; Novi Francesca; Maggio Roberto; Qasem Ahmed R; Spampinato Santi
Deoxamuscaroneoxime derivatives as useful muscarinic agonists to explore the muscarinic subsite: demox, a modulator of orthosteric and allosteric sites at cardiac muscarinic M2 receptors.
Life sciences 2002;70(12):1427-46.
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2002: Gentili Francesco; Bousquet Pascal; Brasili Livio; Caretto Mariangela; Carrieri Antonio; Dontenwill Monique; Giannella Mario; Marucci Gabriella; Perfumi Marina; Piergentili Alessandro; Quaglia Wilma; Rascente Carla; Pigini Maria
Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.
Journal of medicinal chemistry 2002;45(1):32-40.
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2000: Ferretti G; Dukat M; Giannella M; Piergentili A; Pigini M; Quaglia W; Damaj M I; Martin B R; Glennon R A
Chain-lengthened and imidazoline analogues of nicotine.
Bioorganic & medicinal chemistry letters 2000;10(23):2665-8.
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2000: Greney H; Ronde P; Magnier C; Maranca F; Rascente C; Quaglia W; Giannella M; Pigini M; Brasili L; Lugnier C; Bousquet P; Dontenwill M
Coupling of I(1) imidazoline receptors to the cAMP pathway: studies with a highly selective ligand, benazoline.
Molecular pharmacology 2000;57(6):1142-51.
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2000: Pigini M; Quaglia W; Gentili F; Marucci G; Cantalamessa F; Franchini S; Sorbi C; Brasili L
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline.
Bioorganic & medicinal chemistry 2000;8(5):883-8.
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2000: Melchiorre C; Angeli P; Bolognesi M L; Chiarini A; Giardinà D; Gulini U; Leonardi A; Marucci G; Minarini A; Pigini M; Quaglia W; Rosini M; Tumiatti V
Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety.
Pharmaceutica acta Helvetiae 2000;74(2-3):181-90.
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2000: Polidori C; Gentili F; Pigini M; Quaglia W; Panocka I; Massi M
Hyperphagic effect of novel compounds with high affinity for imidazoline I(2) binding sites.
European journal of pharmacology 2000;392(1-2):41-9.
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1999: Quaglia W; Pigini M; Piergentili A; Giannella M; Marucci G; Poggesi E; Leonardi A; Melchiorre C
Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes.
Journal of medicinal chemistry 1999;42(15):2961-8.
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1999: Quaglia W; Bousquet P; Pigini M; Carotti A; Carrieri A; Dontenwill M; Gentili F; Giannella M; Maranca F; Piergentili A; Brasili L
2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors.
Journal of medicinal chemistry 1999;42(15):2737-40.
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1999: Pigini M; Bousquet P; Brasili L; Carrieri A; Dontenwill M; Gentili F; Giannella M; Leonetti F; Piergentili A; Quaglia W; Carotti A
Binding of tracizolines to the imidazoline receptor. Role of lipophilicity in quantitative structure-activity relationship models.
Annals of the New York Academy of Sciences 1999;881():118-22.
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1998: Pigini M; Bousquet P; Brasili L; Carrieri A; Cavagna R; Dontenwill M; Gentili F; Giannella M; Leonetti F; Piergentili A; Quaglia W; Carotti A
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models.
Bioorganic & medicinal chemistry 1998;6(12):2245-60.
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1998: Quaglia W; Giannella M; Piergentili A; Pigini M; Brasili L; Di Toro R; Rossetti L; Spampinato S; Melchiorre C
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.
Journal of medicinal chemistry 1998;41(10):1557-60.
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1998: Melchiorre C; Bolognesi M L; Budriesi R; Chiarini A; Giardinà D; Minarini A; Quaglia W; Leonardi A
Search for selective antagonists at alpha 1-adrenoreceptors: neutral or negative antagonism?
Farmaco (Società chimica italiana : 1989) 1998;53(4):278-86.
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1997: Tayebati S K; Giannella M; Piergentili A; Pigini M; Quaglia W; Sabbatini M; Amenta F
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1997;19(7):1023-46.
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1997: Pigini M; Bousquet P; Carotti A; Dontenwill M; Giannella M; Moriconi R; Piergentili A; Quaglia W; Tayebati S K; Brasili L
Imidazoline receptors: qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity.
Bioorganic & medicinal chemistry 1997;5(5):833-41.
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1997: Angeli P; Brasili L; Cingolani M L; Marucci G; Piergentili A; Pigini M; Quaglia W
Synthesis and structure-activity relationship studies in a series of 2-substituted 1,3-dioxolanes modified at the cationic head.
Bioorganic & medicinal chemistry 1997;5(4):731-7.
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1996: Piergentili A; Pigini M; Quaglia W; Tayebati S K; Amenta F; Sabbatini M; Giannella M
Muscarinic thioligands with cyclopentane nucleus.
Bioorganic & medicinal chemistry 1996;4(12):2193-9.
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1996: Quaglia W; Pigini M; Tayebati S K; Piergentili A; Giannella M; Leonardi A; Taddei C; Melchiorre C
Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist.
Journal of medicinal chemistry 1996;39(11):2253-8.
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1996: Piergentili A; Angeli P; Giannella M; Pigini M; Quaglia W; Tayebati S K
Bicyclic dioxolanes as potential antimuscarinic agents.
Arzneimittel-Forschung 1996;46(2):99-105.
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1996: Quaglia W; Giannella M; Marucci G; Piergentili A; Pigini M; Tayebati S K; Melchiorre C
Structure-activity relationships in 1,4-benzodioxan-related compounds. 5. Effects of modification of the side chain on alpha-adrenoreceptor blocking activity.
Farmaco (Società chimica italiana : 1989) 1996;51(1):27-32.
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1995: Brasili L; Pigini M; Marucci G; Quaglia W; Malmusi L; Lanier S M; Lanier B
Separation of alpha-adrenergic and imidazoline/guanidinium receptive sites (IGRS) activity in a series of imidazoline analogues of cirazoline.
Bioorganic & medicinal chemistry 1995;3(11):1503-9.
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1994: Giannella M; Piergentili A; Pigini M; Quaglia W; Rafaiani G; Tayebati S K
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide.
Chemical & pharmaceutical bulletin 1994;42(6):1286-90.
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1994: Piergentili A; Quaglia W; Tayebati S K; Paparelli F; Malmusi L; Brasili L
Synthesis and muscarinic receptors affinity of a series of antagonist bivalent ligands.
Farmaco (Società chimica italiana : 1989) 1994;49(2):83-7.
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1993: Quaglia W; Pigini M; Tayebati S K; Piergentili A; Giannella M; Marucci G; Melchiorre C
Structure-activity relationships in 1,4-benzodioxan-related compounds. 4. Effect of aryl and alkyl substituents at position 3 on alpha-adrenoreceptor blocking activity.
Journal of medicinal chemistry 1993;36(11):1520-8.
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1991: Giardinà D; Marrazzo A; Marucci G; Piloni M G; Quaglia W
Methoctramine-related polymethylene tetraamines. 4. Chirality effect on M2 muscarinic receptor blocking activity.
Farmaco (Società chimica italiana : 1989) 1991;46(7-8):861-72.
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1991: Quaglia W; Giardinà D; Marucci G; Melchiorre C; Minarini A; Tumiatti V
Structure-activity relationships among methoctramine-related polymethylene tetraamines. 3. Effect of the four nitrogens on M2 muscarinic blocking activity as revealed by symmetrical and unsymmetrical polyamines.
Farmaco (Società chimica italiana : 1989) 1991;46(3):417-34.
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1990: Quaglia W; Pigini M; Giannella M; Melchiorre C
3-Phenyl analogues of 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]-methyl]-1,4-benzodioxan (WB 4101) as highly selective alpha 1-adrenoceptor antagonists.
Journal of medicinal chemistry 1990;33(11):2946-8.
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1989: Melchiorre C; Minarini A; Angeli P; Giardinà D; Gulini U; Quaglia W
Polymethylene tetraamines as muscarinic receptor probes.
Trends in pharmacological sciences 1989;Suppl():55-9.
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1989: Melchiorre C; Quaglia W; Picchio M T; Giardinà D; Brasili L; Angeli P
Structure-activity relationships among methoctramine-related polymethylene tetraamines. Chain-length and substituent effects on M-2 muscarinic receptor blocking activity.
Journal of medicinal chemistry 1989;32(1):79-84.
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1989: Giardinà D; Brasili L; Gregori M; Massi M; Picchio M T; Quaglia W; Melchiorre C
Structure-activity relationships in prazosin-related compounds. Effect of replacing a piperazine ring with an alkanediamine moiety on alpha 1-adrenoreceptor blocking activity.
Journal of medicinal chemistry 1989;32(1):50-5.
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1988: Melchiorre C; Giardinà D; Gulini U; Pigini M; Quaglia W
Benzodioxanes and quinazolines: probes for characterizing alpha-adrenoreceptors.
Il Farmaco; edizione scientifica 1988;43(12 Suppl):1141-52.
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1988: Pigini M; Brasili L; Giannella M; Giardinà D; Gulini U; Quaglia W; Melchiorre C
Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha 1-adrenoreceptor blocking activity.
Journal of medicinal chemistry 1988;31(12):2300-4.
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1988: Quaglia W; Brasili L; Cristalli G; Giardinà D; Picchio M T; Melchiorre C
Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity.
Journal of medicinal chemistry 1988;31(9):1861-6.
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1988: Melchiorre C; Cassinelli A; Brasili L; Giardinà D; Gulini U; Quaglia W
Alpha-adrenoceptor occupancy by N,N-dimethyl-2-bromo-2-phenethylamine hydrobromide (DMPEA) in rat vas deferens.
European journal of pharmacology 1988;153(2-3):255-61.
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1987: Brasili L; Cantalamessa F; Picchio M T; Quaglia W
Fluoronorepinephrines: further pharmacological evaluation in vitro and in pithed rats.
European journal of pharmacology 1987;144(2):141-6.
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1987: Melchiorre C; Cassinelli A; Quaglia W
Differential blockade of muscarinic receptor subtypes by polymethylene tetraamines. Novel class of selective antagonists of cardiac M-2 muscarinic receptors.
Journal of medicinal chemistry 1987;30(1):201-4.
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1985: Angeli P; Brasili L; Brancia E; Giardinà D; Quaglia W; Melchiorre C
Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors.
Journal of medicinal chemistry 1985;28(11):1643-7.
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