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Hartmut Beug

Research Profile

Physiology

Living Beings

Anatomy

Disorders

Cell Transformation, Neoplastic

Chemicals & Drugs

Genes & Molecular Sequences

Oncogenes

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Publications

TOP 3
Maryline Allegra; Hartmut Beug; Marina Ioannou; Gabriele Litos; Elena Vorgia; Andreas Zaragkoulias; George Mavrothalassitis
Semaphorin-7a reverses the ERF-induced inhibition of EMT in Ras-dependent mouse mammary epithelial cells.
Boris Kovacic; Gabriele Litos; Richard Moriggl; Christian Schuster; Veronika Sexl; Gabriele Stengl; Memetcan Alacakaptan; Katrin M Fischhuber; Andrea Hoelbl; Marc Kerenyi; Hartmut Beug
Diverging fates of cells of origin in acute and chronic leukaemia.
Simon M Schultze; Erwin F Wagner; Hartmut Beug; Jin Cen; Dan Li; Andreas Mairhofer; Lijian Hui
p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis.

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2012: Maryline Allegra; Hartmut Beug; Marina Ioannou; Gabriele Litos; Elena Vorgia; Andreas Zaragkoulias; George Mavrothalassitis
Semaphorin-7a reverses the ERF-induced inhibition of EMT in Ras-dependent mouse mammary epithelial cells.
Molecular biology of the cell 2012;23(19):3873-81.
2012: Boris Kovacic; Gabriele Litos; Richard Moriggl; Christian Schuster; Veronika Sexl; Gabriele Stengl; Memetcan Alacakaptan; Katrin M Fischhuber; Andrea Hoelbl; Marc Kerenyi; Hartmut Beug
Diverging fates of cells of origin in acute and chronic leukaemia.
EMBO molecular medicine 2012;4(4):283-97.
2012: Simon M Schultze; Erwin F Wagner; Hartmut Beug; Jin Cen; Dan Li; Andreas Mairhofer; Lijian Hui
p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis.
Cell research 2012;22(3):539-50.
2011: Florian Grebien; Oliver Hantschel; Ines Kaupe; Akiko Koide; Shohei Koide; Boris Kovacic; Tony Pawson; Hartmut Beug; Sabine Cerny-Reiterer; Gerald D Gish; Peter Valent; John Wojcik; Arkadiusz M Wyrzucki; Giulio Superti-Furga
Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.
Cell 2011;147(2):306-19.
2011: Julio L Sampaio; Mathias J Gerl; Christian Klose; Christer S Ejsing; Hartmut Beug; Kai Simons; Andrej Shevchenko
Membrane lipidome of an epithelial cell line.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(5):1903-7.
2010: Sabine Maschler; Christoph A Gebeshuber; Eva-Maria Wiedemann; Memetcan Alacakaptan; Martin Schreiber; Ivana Custic; Hartmut Beug
Annexin A1 attenuates EMT and metastatic potential in breast cancer.
EMBO molecular medicine 2010;2(10):401-14.
2010: Harald J Maier; Uta Schmidt-Strassburger; Margit A Huber; Eva M Wiedemann; Hartmut Beug; Thomas Wirth
NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells.
Cancer letters 2010;295(2):214-28.
2010: Katrin Friedbichler; Marc A Kerenyi; Boris Kovacic; Geqiang Li; Andrea Hoelbl; Saliha Yahiaoui; Veronika Sexl; Ernst W Müllner; Sabine Fajmann; Sabine Cerny-Reiterer; Peter Valent; Hartmut Beug; Fabrice Gouilleux; Kevin D Bunting; Richard Moriggl
Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation.
Blood 2010;116(9):1548-58.
2010: Agnes Csiszar; Elisabeth Vogelsang; Hartmut Beug; Maria Leptin
A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission.
Molecular and cellular biology 2010;30(8):2017-27.
2010: Andrea Hoelbl; Christian Schuster; Boris Kovacic; Bingmei Zhu; Mark Wickre; Maria A Hoelzl; Sabine Fajmann; Florian Grebien; Wolfgang Warsch; Gabriele Stengl; Lothar Hennighausen; Valeria Poli; Hartmut Beug; Richard Moriggl; Veronika Sexl
Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia.
EMBO molecular medicine 2010;2(3):98-110.
2010: Margit A Huber; Norbert Kraut; Jeffrey B Madwed; Harald J Maier; Daniel R Marshall; Hubert Pehamberger; Eva Wiedemann; Thomas Wirth; Erick R R Young; Memetcan Alacakaptan; Guido Boehmelt; Jürgen Braunger; Hartmut Beug
BI 5700, a Selective Chemical Inhibitor of IκB Kinase 2, Specifically Suppresses Epithelial-Mesenchymal Transition and Metastasis in Mouse Models of Tumor Progression.
Genes & cancer 2010;1(2):101-14.
2010: Gudrun Zulehner; Mario Mikula; Doris Schneller; Franziska van Zijl; Heidemarie Huber; Wolfgang Sieghart; Bettina Grasl-Kraupp; Thomas Waldhör; Markus Peck-Radosavljevic; Hartmut Beug; Wolfgang Mikulits
Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence.
The American journal of pathology 2010;176(1):472-81.
2009: F van Zijl; M Mair; Agnes Csiszar; D Schneller; G Zulehner; Heidemarie Huber; R Eferl; Hartmut Beug; Helmut Dolznig; Wolfgang Mikulits
Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge.
Oncogene 2009;28(45):4022-33.
2009: Hartmut Beug
Breast cancer stem cells: eradication by differentiation therapy?
Cell 2009;138(4):623-5.
2009: C Lahsnig; Mario Mikula; M Petz; G Zulehner; D Schneller; F van Zijl; Heidemarie Huber; Agnes Csiszar; Hartmut Beug; Wolfgang Mikulits
ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression.
Oncogene 2009;28(5):638-50.
2009: Andrea Ecker; Olivia Simma; Andrea Hoelbl; Lukas Kenner; Hartmut Beug; Richard Moriggl; Veronika Sexl
The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor.
Frontiers in bioscience : a journal and virtual library 2009;14():2944-58.
2008: Marc Kerenyi; Florian Grebien; Helmuth Gehart; Manfred Schifrer; Matthias Artaker; Boris Kovacic; Hartmut Beug; Richard Moriggl; Ernst W Müllner
Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.
Blood 2008;112(9):3878-88.
2008: Godfrey Grech; Montserrat Blázquez-Domingo; Andrea Kolbus; Walbert J Bakker; Ernst W Müllner; Hartmut Beug; Marieke von Lindern
Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation.
Blood 2008;112(7):2750-60.
2008: Philipp Schähs; Petra Weidinger; Olivia C Probst; Barbara Svoboda; Johannes Stadlmann; Hartmut Beug; Thomas Waerner; Lukas Mach
Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis.
Experimental cell research 2008;314(16):3036-47.
2008: Florian Grebien; Marc Kerenyi; Boris Kovacic; Thomas Kolbe; Verena Becker; Helmut Dolznig; Klaus Pfeffer; Ursula Klingmüller; Mathias Müller; Hartmut Beug; Ernst W Müllner; Richard Moriggl
Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2.
Blood 2008;111(9):4511-22.
2008: Jan-Wilhelm Kornfeld; Florian Grebien; Marc A Kerenyi; Katrin Friedbichler; Boris Kovacic; Barbara Zankl; Andrea Hoelbl; Harini Nivarti; Hartmut Beug; Veronika Sexl; Mathias Muller; Lukas Kenner; Ernst W Mullner; Fabrice Gouilleux; Richard Moriggl
The different functions of Stat5 and chromatin alteration through Stat5 proteins.
Frontiers in bioscience : a journal and virtual library 2008;13():6237-54.
2007: Kurt Aigner; Brigitta Dampier; L Descovich; Mario Mikula; A Sultan; Martin Schreiber; Wolfgang Mikulits; Thomas Brabletz; D Strand; P Obrist; Wolfgang Sommergruber; Norbert Schweifer; A Wernitznig; Hartmut Beug; Roland Foisner; Andreas Eger
The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.
Oncogene 2007;26(49):6979-88.
2007: Lijian Hui; Latifa Bakiri; Andreas Mairhorfer; Norbert Schweifer; Christian Haslinger; Lukas Kenner; Vukoslav Komnenovic; Harald Scheuch; Hartmut Beug; Erwin F Wagner
p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway.
Nature genetics 2007;39(6):741-9.
2007: Oliver Rath; Adi Himmler; Anke Baum; Wolfgang Sommergruber; Hartmut Beug; Thomas Metz
c-Myc is required for transformation of FDC-P1 cells by EGFRvIII.
FEBS letters 2007;581(13):2549-56.
2007: A N M Fischer; Eva Fuchs; Mario Mikula; Heidemarie Huber; Hartmut Beug; Wolfgang Mikulits
PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression.
Oncogene 2007;26(23):3395-405.
2007: David Engblom; Jan-Wilhelm Kornfeld; Lukas Schwake; François Tronche; Andreas Reimann; Hartmut Beug; Lothar Hennighausen; Richard Moriggl; Günther Schütz
Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression.
Genes & development 2007;21(10):1157-62.
2007: Walbert J Bakker; Thamar B van Dijk; Martine Parren-van Amelsvoort; Andrea Kolbus; Kazuo Yamamoto; Peter Steinlein; Roel G W Verhaak; Tak W Mak; Hartmut Beug; Bob Löwenberg; Marieke von Lindern
Differential regulation of Foxo3a target genes in erythropoiesis.
Molecular and cellular biology 2007;27(10):3839-3854.
2007: Kurt Aigner; Luise Descovich; Mario Mikula; Aneesa Sultan; Brigitta Dampier; Stefan Bonné; Frans van Roy; Wolfgang Mikulits; Martin Schreiber; Thomas Brabletz; Wolfgang Sommergruber; Norbert Schweifer; Andreas Wernitznig; Hartmut Beug; Roland Foisner; Andreas Eger
The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression.
FEBS letters 2007;581(8):1617-24.
2007: Nana Naetar; Sabine Hutter; Daniela Dorner; Thomas Dechat; Barbara Korbei; Josef Gotzmann; Hartmut Beug; Roland Foisner
LAP2alpha-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit.
Journal of cell science 2007;120(Pt 5):737-47.
2007: Noria Harir; Christian Pecquet; Marc Kerenyi; Karoline Sonneck; Boris Kovacic; Rémy Nyga; Marie Brevet; Isabelle Dhennin; Valérie Gouilleux-Gruart; Hartmut Beug; Peter Valent; Kaiss Lassoued; Richard Moriggl; Fabrice Gouilleux
Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias.
Blood 2007;109(4):1678-86.
2006: Elzbieta Janda; M Nevolo; K Lehmann; Julian Downward; Hartmut Beug; Michele Grieco
Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin.
Oncogene 2006;25(54):7117-30.
2006: Thomas Waerner; Memetcan Alacakaptan; Ido Tamir; Rupert Oberauer; Annamaria Gal; Thomas Brabletz; Martin Schreiber; Martin Jechlinger; Hartmut Beug
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.
Cancer cell 2006;10(3):227-39.
2006: Angel Hernandez-Hernandez; Pampa Ray; Gabi Litos; Marco Ciro; Sergio Ottolenghi; Hartmut Beug; Joan Boyes
Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1.
The EMBO journal 2006;25(14):3264-74.
2006: Boris Kovacic; Dagmar Stoiber; Richard Moriggl; Eva Weisz; René G Ott; Rita Kreibich; David E Levy; Hartmut Beug; Michael Freissmuth; Veronika Sexl
STAT1 acts as a tumor promoter for leukemia development.
Cancer cell 2006;10(1):77-87.
2006: Cristina Rubiolo; Daniela Piazzolla; Katrin Meissl; Hartmut Beug; Johannes C Huber; Andrea Kolbus; Manuela Baccarini
A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation.
Blood 2006;108(1):152-9.
2006: Andrea Hoelbl; Boris Kovacic; Marc Kerenyi; Olivia Simma; Wolfgang Warsch; Yongzhi Cui; Hartmut Beug; Lothar Hennighausen; Richard Moriggl; Veronika Sexl
Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.
Blood 2006;107(12):4898-906.
2006: Martin Jechlinger; Andreas Sommer; Richard Moriggl; Peter Seither; Norbert Kraut; Paola Capodiecci; Michael Donovan; Carlos Cordon-Cardo; Hartmut Beug; stefan gruenert
Autocrine PDGFR signaling promotes mammary cancer metastasis.
The Journal of clinical investigation 2006;116(6):1561-70.
2006: Josef Gotzmann; A N M Fischer; M Zojer; Mario Mikula; Verena Proell; Heidemarie Huber; Martin Jechlinger; Thomas Waerner; Andreas Weith; Hartmut Beug; Wolfgang Mikulits
A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytes.
Oncogene 2006;25(22):3170-85.
2006: Matthias Schranzhofer; Manfred Schifrer; Javier Antonio Cabrera; Stephan Kopp; Peter Chiba; Hartmut Beug; Ernst W Müllner
Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis.
Blood 2006;107(10):4159-67.
2006: Helmut Dolznig; Florian Grebien; Eva Maria Deiner ; Katharina Stangl; Andrea Kolbus; Bianca Habermann; Marc Kerenyi; M Kieslinger; Richard Moriggl; Hartmut Beug; Ernst W Müllner
Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR.
Oncogene 2006;25(20):2890-900.
2005: Margit A Huber; Norbert Kraut; Hartmut Beug
Molecular requirements for epithelial-mesenchymal transition during tumor progression.
Current opinion in cell biology 2005;17(5):548-58.
2005: Sandra Pilat; Sebastian Carotta; Bernhard Schiedlmeier; Kenji Kamino; Andreas Mairhofer; Elke Will; Ute Modlich; Peter Steinlein; Wolfram Ostertag; Christopher Baum; Hartmut Beug; Hannes Klump
HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12101-6.
2005: Florian M Corvinus; Carina Orth; Richard Moriggl; Svetlana A Tsareva; Stefan Wagner; Edith Pfitzner; Daniela Baus; Roland Kaufmann; Lukas A Huber; Kurt Zatloukal; Hartmut Beug; Peter Ohlschläger; Alexander Schütz; Karl-Jürgen Halbhuber; Karlheinz Friedrich
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth.
Neoplasia (New York, N.Y.) 2005;7(6):545-55.
2005: Roy Drissen; Marieke von Lindern; Andrea Kolbus; Siska Driegen; Peter Steinlein; Hartmut Beug; Frank Grosveld; Sjaak Philipsen
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.
Molecular and cellular biology 2005;25(12):5205-14.
2005: A N M Fischer; Blanca Herrera; Mario Mikula; Verena Proell; Eva Fuchs; Josef Gotzmann; Rolf Schulte-Hermann; Hartmut Beug; Wolfgang Mikulits
Integration of Ras subeffector signaling in TGF-beta mediated late stage hepatocarcinogenesis.
Carcinogenesis 2005;26(5):931-42.
2005: Andreas Eger; Kurt Aigner; Stefan Sonderegger; Brigitta Dampier; Susanne Oehler; Martin Schreiber; Geert Berx; Amparo Cano; Hartmut Beug; Roland Foisner
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.
Oncogene 2005;24(14):2375-85.
2005: Sabine Maschler; Gerhard Wirl; Herbert Spring; Dorothea V Bredow; Isabelle Sordat; Hartmut Beug; Ernst Reichmann
Tumor cell invasiveness correlates with changes in integrin expression and localization.
Oncogene 2005;24(12):2032-41.
2005: Florian Grebien; Helmut Dolznig; Hartmut Beug; Ernst W Mullner
Cell size control: new evidence for a general mechanism.
Cell cycle (Georgetown, Tex.) 2005;4(3):418-21.
2005: Cristina Angelin-Duclos; Chantal Domenget; Andrea Kolbus; Hartmut Beug; Pierre Jurdic; Jacques Samarut
Thyroid hormone T3 acting through the thyroid hormone alpha receptor is necessary for implementation of erythropoiesis in the neonatal spleen environment in the mouse.
Development (Cambridge, England) 2005;132(5):925-34.
2005: Richard Moriggl; Veronika Sexl; Lukas Kenner; Christopher D Duntsch; Katharina Stangl; Suzanne Gingras; Angelika Hoffmeyer; anton bauer; Roland P Piekorz; Demin Wang; Kevin D Bunting; Erwin F Wagner; Karoline Sonneck; Peter Valent; James N Ihle; Hartmut Beug
Stat5 tetramer formation is associated with leukemogenesis.
Cancer cell 2005;7(1):87-99.
2005: Helmut Dolznig; Andrea Kolbus; Cornelia Leberbauer; Uwe Schmidt; Eva Maria Deiner ; Ernst W Müllner; Hartmut Beug
Expansion and differentiation of immature mouse and human hematopoietic progenitors.
Methods in molecular medicine 2005;105():323-44.
2005: Cornelia Leberbauer; Florence Boulmé; Gertrud Unfried; Johannes Huber; Hartmut Beug; Ernst W Müllner
Different steroids co-regulate long-term expansion versus terminal differentiation in primary human erythroid progenitors.
Blood 2005;105(1):85-94.
2004: Margit A Huber; Hartmut Beug; Thomas Wirth
Epithelial-mesenchymal transition: NF-kappaB takes center stage.
Cell cycle (Georgetown, Tex.) 2004;3(12):1477-80.
2004: Sebastian Carotta; Sandra Pilat; Andreas Mairhofer; Uwe Schmidt; Helmut Dolznig; Peter Steinlein; Hartmut Beug
Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells.
Blood 2004;104(6):1873-80.
2004: Marieke Joosten; Montserrat Blázquez-Domingo; Fokke Lindeboom; Florence Boulmé; Antoinette Van Hoven-Beijen; Bianca Habermann; Bob Löwenberg; Hartmut Beug; Ernst W Müllner; Ruud Delwel; Marieke von Lindern
Translational control of putative protooncogene Nm23-M2 by cytokines via phosphoinositide 3-kinase signaling.
The Journal of biological chemistry 2004;279(37):38169-76.
2004: Helmut Dolznig; Florian Grebien; Thomas Sauer; Hartmut Beug; Ernst W Müllner
Evidence for a size-sensing mechanism in animal cells.
Nature cell biology 2004;6(9):899-905.
2004: Margit A Huber; Ninel Azoitei; Bernd Baumann; stefan gruenert; Andreas Sommer; Hubert Pehamberger; Norbert Kraut; Hartmut Beug; Thomas Wirth
NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression.
The Journal of clinical investigation 2004;114(4):569-81.
2004: Marieke von Lindern; Uwe Schmidt; Hartmut Beug
Control of erythropoiesis by erythropoietin and stem cell factor: a novel role for Bruton's tyrosine kinase.
Cell cycle (Georgetown, Tex.) 2004;3(7):876-9.
2004: emile van den akker; Thamar B van Dijk; Uwe Schmidt; Lamberto Felida; Hartmut Beug; Bob Löwenberg; Marieke von Lindern
The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity.
Biological chemistry 2004;385(5):409-13.
2004: Sabine Maschler; stefan gruenert; Adriana Danielopol; Hartmut Beug; Gerhard Wirl
Enhanced tenascin-C expression and matrix deposition during Ras/TGF-beta-induced progression of mammary tumor cells.
Oncogene 2004;23(20):3622-33.
2004: Andreas Eger; Andreas Stockinger; John Park; Elke Langkopf; Mario Mikula; Josef Gotzmann; Wolfgang Mikulits; Hartmut Beug; Roland Foisner
beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition.
Oncogene 2004;23(15):2672-2680.
2004: Uwe Schmidt; emile van den akker; Martine Parren-van Amelsvoort; Gabi Litos; Marella de Bruijn; Laura Gutiérrez; Rudolf W Hendriks; Wilfried Ellmeier; Bob Löwenberg; Hartmut Beug; Marieke von Lindern
Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.
The Journal of experimental medicine 2004;199(6):785-95.
2004: François Tronche; Christian Opherk; Richard Moriggl; Christoph Kellendonk; Andreas Reimann; Lukas Schwake; Holger M Reichardt; Katharina Stangl; Daniel Gau; Andreas Hoeflich; Hartmut Beug; Wolfgang Schmid; Günther Schütz
Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth.
Genes & development 2004;18(5):492-7.
2004: Mario Mikula; Eva Fuchs; Heidemarie Huber; Hartmut Beug; Rolf Schulte-Hermann; Wolfgang Mikulits
Immortalized p19ARF null hepatocytes restore liver injury and generate hepatic progenitors after transplantation.
Hepatology (Baltimore, Md.) 2004;39(3):628-34.
2004: Walbert J Bakker; Montserrat Blázquez-Domingo; Andrea Kolbus; Janey Besooyen; Peter Steinlein; Hartmut Beug; Paul J Coffer; Bob Löwenberg; Marieke von Lindern; Thamar B van Dijk
FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1.
The Journal of cell biology 2004;164(2):175-84.
2004: Josef Gotzmann; Mario Mikula; Andreas Eger; Rolf Schulte-Hermann; Roland Foisner; Hartmut Beug; Wolfgang Mikulits
Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis.
Mutation research 2004;566(1):9-20.
2003: Sébastien Dazy; Francesca Damiola; Nicolas Parisey; Hartmut Beug; Olivier Gandrillon
The MEK-1/ERKs signalling pathway is differentially involved in the self-renewal of early and late avian erythroid progenitor cells.
Oncogene 2003;22(58):9205-16.
2003: Ingrid Lebigot; Paola Gardellin; Laurent Lefebvre; Hartmut Beug; Jacques Ghysdael; Christine Tran Quang
Up-regulation of SLAP in FLI-1-transformed erythroblasts interferes with EpoR signaling.
Blood 2003;102(13):4555-62.
2003: Andrea Kolbus; Montserrat Blázquez-Domingo; Sebastian Carotta; Walbert J Bakker; Susanna Luedemann; Marieke von Lindern; Peter Steinlein; Hartmut Beug
Cooperative signaling between cytokine receptors and the glucocorticoid receptor in the expansion of erythroid progenitors: molecular analysis by expression profiling.
Blood 2003;102(9):3136-46.
2003: Martin Jechlinger; stefan gruenert; Ido H Tamir; Elzbieta Janda; Susanna Lüdemann; Thomas Waerner; Peter Seither; Andreas Weith; Hartmut Beug; Norbert Kraut
Expression profiling of epithelial plasticity in tumor progression.
Oncogene 2003;22(46):7155-69.
2003: Mario Mikula; Josef Gotzmann; A N M Fischer; Markus F Wolschek; Christiane Thallinger; Rolf Schulte-Hermann; Hartmut Beug; Wolfgang Mikulits
The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesis.
Oncogene 2003;22(43):6725-38.
2003: stefan gruenert; Martin Jechlinger; Hartmut Beug
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.
Nature reviews. Molecular cell biology 2003;4(8):657-65.
2002: Andrea Kolbus; Sandra Pilat; Zvenyslava Husak; Eva Maria Deiner ; Gabriele Stengl; Hartmut Beug; Manuela Baccarini
Raf-1 antagonizes erythroid differentiation by restraining caspase activation.
The Journal of experimental medicine 2002;196(10):1347-53.
2002: Martin Jechlinger; stefan gruenert; Hartmut Beug
Mechanisms in epithelial plasticity and metastasis: insights from 3D cultures and expression profiling.
Journal of mammary gland biology and neoplasia 2002;7(4):415-32.
2002: Cathleen E Schulte; Marieke von Lindern; Peter Steinlein; Hartmut Beug; Leanne M Wiedemann
MLL-ENL cooperates with SCF to transform primary avian multipotent cells.
The EMBO journal 2002;21(16):4297-306.
2002: Heike Stroissnigg; Marion Repitz; Angelina Miloloza; Irena Linhartova; Hartmut Beug; Gerhard Wiche; Friedrich Propst
FIP-2, an IkappaB-kinase-gamma-related protein, is associated with the Golgi apparatus and translocates to the marginal band during chicken erythroblast differentiation.
Experimental cell research 2002;278(2):133-45.
2002: Elzbieta Janda; Gabi Litos; stefan gruenert; Julian Downward; Hartmut Beug
Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway.
Oncogene 2002;21(33):5148-59.
2002: Beatrix Vécsey-Semjén; Karl-Friedrich Becker; Alexandra Sinski; Elizabeth Blennow; Ilja Vietor; Kurt Zatloukal; Hartmut Beug; Ernst Wagner; Lukas A Huber
Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers.
Oncogene 2002;21(30):4646-62.
2002: Helmut Dolznig; Bianca Habermann; Katharina Stangl; Eva Maria Deiner ; Richard Moriggl; Hartmut Beug; Ernst W Müllner
Apoptosis protection by the Epo target Bcl-X(L) allows factor-independent differentiation of primary erythroblasts.
Current biology : CB 2002;12(13):1076-85.
2002: Lioba Lobmayr; Thomas Sauer; Iris Killisch; Matthias Schranzhofer; Robert B Wilson; Prem Ponka; Hartmut Beug; Ernst W Müllner
Transferrin receptor hyperexpression in primary erythroblasts is lost on transformation by avian erythroblastosis virus.
Blood 2002;100(1):289-98.
2002: José Manuel González-Sancho; Angélica Figueroa; Mónica López-Barahona; Eva López; Hartmut Beug; Alberto Muñoz
Inhibition of proliferation and expression of T1 and cyclin D1 genes by thyroid hormone in mammary epithelial cells.
Molecular carcinogenesis 2002;34(1):25-34.
2002: Josef Gotzmann; Heidemarie Huber; Christiane Thallinger; Markus F Wolschek; Burkhard Jansen; Rolf Schulte-Hermann; Hartmut Beug; Wolfgang Mikulits
Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness.
Journal of cell science 2002;115(Pt 6):1189-202.
2002: Elzbieta Janda; Kerstin Lehmann; Iris Killisch; Martin Jechlinger; Michaela Herzig; Julian Downward; Hartmut Beug; stefan gruenert
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.
The Journal of cell biology 2002;156(2):299-313.
2001: Andreas Stockinger; Andreas Eger; J Wolf; Hartmut Beug; Roland Foisner
E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity.
The Journal of cell biology 2001;154(6):1185-96.
2001: S Czvitkovich; S Sauer; Antoine H F M Peters; Eva Maria Deiner ; A Wolf; G Laible; Susanne Opravil; Hartmut Beug; Thomas Jenuwein
Over-expression of the SUV39H1 histone methyltransferase induces altered proliferation and differentiation in transgenic mice.
Mechanisms of development 2001;107(1-2):141-53.
2001: J F Hofmann; M Sykora; N Redemann; Hartmut Beug
G1-Cdk activity is required for both proliferation and viability of cytokine-dependent myeloid and erythroid cells.
Oncogene 2001;20(31):4198-208.
2001: Marieke von Lindern; Eva Maria Deiner ; Helmut Dolznig; Martine Parren-van Amelsvoort; Michael J Hayman; E W Mullner; Hartmut Beug
Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis.
Oncogene 2001;20(28):3651-64.
2001: Helmut Dolznig; Florence Boulmé; Katharina Stangl; Eva Maria Deiner ; Wolfgang Mikulits; Hartmut Beug; Ernst W Müllner
Establishment of normal, terminally differentiating mouse erythroid progenitors: molecular characterization by cDNA arrays.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(8):1442-4.
2001: M Mikula; M Schreiber; Zvenyslava Husak; Lucia Kucerova; J Rüth; R Wieser; K Zatloukal; Hartmut Beug; E F Wagner; Manuela Baccarini
Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene.
The EMBO journal 2001;20(8):1952-62.
2001: Bérengère Pradet-Balade; Florence Boulmé; Hartmut Beug; Ernst W Müllner; Jose A. Garcia-Sanz
Translation control: bridging the gap between genomics and proteomics?
Trends in biochemical sciences 2001;26(4):225-9.
2000: C Petritsch; Hartmut Beug; Allan Balmain; Martin Oft
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest.
Genes & development 2000;14(24):3093-101.
2000: Marieke von Lindern; Martine Parren-van Amelsvoort; Thamar B van Dijk; Eva Maria Deiner ; emile van den akker; Sjenet E van Emst-De Vries; Peter Willems; Hartmut Beug; Bob Löwenberg
Protein kinase C alpha controls erythropoietin receptor signaling.
The Journal of biological chemistry 2000;275(44):34719-27.
2000: K Lehmann; Elzbieta Janda; CE Pierreux; M Rytömaa; A Schulze; M McMahon; Caroline S Hill; Hartmut Beug; Julian Downward
Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells.
Genes & development 2000;14(20):2610-22.
2000: Wolfgang Mikulits; Matthias Schranzhofer; Eva Maria Deiner ; Hartmut Beug; Ernst W Müllner
Regulation of ferritin mRNA translation in primary erythroblasts: exogenous c-Kit plus EpoR signaling mimics v-ErbA oncoprotein activity.
Biochemical and biophysical research communications 2000;275(2):292-4.
2000: Wolfgang Mikulits; Bérengère Pradet-Balade; Bianca Habermann; Hartmut Beug; Jose A. Garcia-Sanz; Ernst W Müllner
Isolation of translationally controlled mRNAs by differential screening.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(11):1641-52.
2000: Jacques Ghysdael; C Tran Quang; Eva Maria Deiner ; Helmut Dolznig; Ernst W Müllner; Hartmut Beug
Erythroid cell development and leukemic transformation: interplay between signal transduction, cell cycle control and oncogenes.
Pathologie-biologie 2000;48(3):211-26.
2000: M Kieslinger; I Woldman; Richard Moriggl; J Hofmann; Jean-Christophe Marine; James N Ihle; Hartmut Beug; Thomas Decker
Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation.
Genes & development 2000;14(2):232-44.
2000: Andreas Eger; Andreas Stockinger; B Schaffhauser; Hartmut Beug; Roland Foisner
Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity.
The Journal of cell biology 2000;148(1):173-88.
1999: Wolfgang Mikulits; Matthias Schranzhofer; anton bauer; Helmut Dolznig; Lioba Lobmayr; Anthony A Infante; Hartmut Beug; Ernst W Müllner
Impaired ferritin mRNA translation in primary erythroid progenitors: shift to iron-dependent regulation by the v-ErbA oncoprotein.
Blood 1999;94(12):4321-32.
1999: anton bauer; François Tronche; O Wessely; Christoph Kellendonk; Holger M Reichardt; Peter Steinlein; Günther Schütz; Hartmut Beug
The glucocorticoid receptor is required for stress erythropoiesis.
Genes & development 1999;13(22):2996-3002.
1999: Wolfgang Mikulits; Matthias Schranzhofer; Hartmut Beug; Ernst W Müllner
Post-transcriptional control via iron-responsive elements: the impact of aberrations in hereditary disease.
Mutation research 1999;437(3):219-30.
1999: S Oliferenko; Karin Paiha; T Harder; V Gerke; Christoph Schwärzler; H Schwarz; Hartmut Beug; Ursula Günthert; Lukas A Huber
Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton.
The Journal of cell biology 1999;146(4):843-54.
1999: Marieke von Lindern; W Zauner; G Mellitzer; Peter Steinlein; G Fritsch; K Huber; Bob Löwenberg; Hartmut Beug
The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro.
Blood 1999;94(2):550-9.
1999: Olivier Gandrillon; U Schmidt; Hartmut Beug; Jacques Samarut
TGF-beta cooperates with TGF-alpha to induce the self-renewal of normal erythrocytic progenitors: evidence for an autocrine mechanism.
The EMBO journal 1999;18(10):2764-81.
1999: M W J C Jansen; Marieke von Lindern; Hartmut Beug; Helen Brandenburg; Hajo I J Wildschut; Juriy W Wladimiroff; PA in 't Veld
The use of in vitro expanded erythroid cells in a model system for the isolation of fetal cells from maternal blood.
Prenatal diagnosis 1999;19(4):323-9.
1999: Rui Pereira; Christine Tran Quang; Isabelle Lesault; Helmut Dolznig; Hartmut Beug; Jacques Ghysdael
FLI-1 inhibits differentiation and induces proliferation of primary erythroblasts.
Oncogene 1999;18(8):1597-608.
1999: O Wessely; anton bauer; Christine Tran Quang; Eva Maria Deiner ; Marieke von Lindern; G Mellitzer; Peter Steinlein; Jacques Ghysdael; Hartmut Beug
A novel way to induce erythroid progenitor self renewal: cooperation of c-Kit with the erythropoietin receptor.
Biological chemistry 1999;380(2):187-202.
1998: Martin Oft; K H Heider; Hartmut Beug
TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis.
Current biology : CB 1998;8(23):1243-52.
1998: Richard Dahl; M Kieslinger; Hartmut Beug; Michael J Hayman
Transformation of hematopoietic cells by the Ski oncoprotein involves repression of retinoic acid receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11187-92.
1998: O Wessely; Eva Maria Deiner ; Kim-Chew Lim; G Mellitzer; Peter Steinlein; Hartmut Beug
Mammalian granulocyte-macrophage colony-stimulating factor receptor expressed in primary avian hematopoietic progenitors: lineage-specific regulation of proliferation and differentiation.
The Journal of cell biology 1998;141(4):1041-51.
1998: Marieke von Lindern; L Boer; O Wessely; M Parker; Hartmut Beug
The transactivation domain AF-2 but not the DNA-binding domain of the estrogen receptor is required to inhibit differentiation of avian erythroid progenitors.
Molecular endocrinology (Baltimore, Md.) 1998;12(2):263-77.
1997: Christine Tran Quang; O Wessely; Martine Pironin; Hartmut Beug; Jacques Ghysdael
Cooperation of Spi-1/PU.1 with an activated erythropoietin receptor inhibits apoptosis and Epo-dependent differentiation in primary erythroblasts and induces their Kit ligand-dependent proliferation.
The EMBO journal 1997;16(18):5639-53.
1997: anton bauer; E Ulrich; M Andersson; Hartmut Beug; Marieke von Lindern
Mechanism of transformation by v-ErbA: substitution for steroid hormone receptor function in self renewal induction.
Oncogene 1997;15(6):701-15.
1997: I Woldman; G Mellitzer; M Kieslinger; D Buchhart; A Meinke; Hartmut Beug; Thomas Decker
STAT5 involvement in the differentiation response of primary chicken myeloid progenitor cells to chicken myelomonocytic growth factor.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):877-86.
1997: Wolfgang Mikulits; Helmut Dolznig; H Edelmann; Thomas Sauer; Eva Maria Deiner ; L Ballou; Hartmut Beug; Ernst W Müllner
Dynamics of cell cycle regulators: artifact-free analysis by recultivation of cells synchronized by centrifugal elutriation.
DNA and cell biology 1997;16(7):849-59.
1997: O Wessely; G Mellitzer; Marieke von Lindern; A Levitzki; A Gazit; Irene Ischenko; Michael J Hayman; Hartmut Beug
Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(5):481-93.
1997: O Wessely; Eva Maria Deiner ; Hartmut Beug; Marieke von Lindern
The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors.
The EMBO journal 1997;16(2):267-80.
1996: Hartmut Beug; anton bauer; Helmut Dolznig; Marieke von Lindern; L Lobmayer; G Mellitzer; Peter Steinlein; O Wessely; E Mullner
Avian erythropoiesis and erythroleukemia: towards understanding the role of the biomolecules involved.
Biochimica et biophysica acta 1996;1288(3):M35-47.
1996: Karoline J Briegel; Petr Bartunek; G Stengl; Kim-Chew Lim; Hartmut Beug; James Douglas Engel; Martin Zenke
Regulation and function of transcription factor GATA-1 during red blood cell differentiation.
Development (Cambridge, England) 1996;122(12):3839-50.
1996: G Mellitzer; O Wessely; Thomas Decker; A Meinke; Michael J Hayman; Hartmut Beug
Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9600-5.
1996: Ernst W Müllner; Helmut Dolznig; Hartmut Beug
Cell cycle regulation and erythroid differentiation.
Current topics in microbiology and immunology 1996;212():175-94.
1996: P Bartůnĕk; L Pichlíková; G Stengl; G Boehmelt; F H Martin; Hartmut Beug; M Dvorák; Martin Zenke
Avian stem cell factor (SCF): production and characterization of the recombinant His-tagged SCF of chicken and its neutralizing antibody.
Cytokine 1996;8(1):14-20.
1995: Helmut Dolznig; P Bartunek; K Nasmyth; Ernst W Müllner; Hartmut Beug
Terminal differentiation of normal chicken erythroid progenitors: shortening of G1 correlates with loss of D-cyclin/cdk4 expression and altered cell size control.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1341-52.
1995: Christine Tran Quang; M Pironin; Marieke von Lindern; Hartmut Beug; Jacques Ghysdael
Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation control of primary erythroid progenitors.
Oncogene 1995;11(7):1229-39.
1995: Hartmut Beug; C Schroeder; O Wessely; Eva Maria Deiner ; S Meyer; Irene Ischenko; Michael J Hayman
Transformation of erythroid progenitors by viral and cellular tyrosine kinases.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(8):999-1008.
1995: Hartmut Beug; Richard Dahl; Peter Steinlein; S Meyer; Eva Maria Deiner ; Michael J Hayman
In vitro growth of factor-dependent multipotential hematopoietic cells is induced by the nuclear oncoprotein v-Ski.
Oncogene 1995;11(1):59-72.
1995: Peter Steinlein; O Wessely; S Meyer; Eva Maria Deiner ; Michael J Hayman; Hartmut Beug
Primary, self-renewing erythroid progenitors develop through activation of both tyrosine kinase and steroid hormone receptors.
Current biology : CB 1995;5(2):191-204.
1995: Hartmut Beug; Peter Steinlein; Petr Bartunek; Michael J Hayman
Avian hematopoietic cell culture: in vitro model systems to study oncogenic transformation of hematopoietic cells.
Methods in enzymology 1995;254():41-76.
1994: Hartmut Beug; E W Müllner; Michael J Hayman
Insights into erythroid differentiation obtained from studies on avian erythroblastosis virus.
Current opinion in cell biology 1994;6(6):816-24.
1994: Björn Vennström; C Raynoscheck; L Jansson; G Doederlein; V Lhotak; A Johnsson; Hartmut Beug
Retroviral capture of c-erbB proto-oncogene sequences: rapid evolution of distinct viral genomes carrying mutant v-erbB genes with different transforming capacities.
Oncogene 1994;9(5):1307-20.
1994: Peter Steinlein; Eva Maria Deiner ; Achim Leutz; Hartmut Beug
Recombinant murine erythropoietin receptor expressed in avian erythroid progenitors mediates terminal erythroid differentiation in vitro.
Growth factors (Chur, Switzerland) 1994;10(1):1-16.
1993: J Larsen; S Meyer; Peter Steinlein; Hartmut Beug; Michael J Hayman
Transformation of chicken bone marrow cells by the v-ski oncogene.
Oncogene 1993;8(12):3221-8.
1993: Michael J Hayman; S Meyer; F Martin; Peter Steinlein; Hartmut Beug
Self-renewal and differentiation of normal avian erythroid progenitor cells: regulatory roles of the TGF alpha/c-ErbB and SCF/c-kit receptors.
Cell 1993;74(1):157-69.
1993: Karoline J Briegel; Kim-Chew Lim; C Plank; Hartmut Beug; James Douglas Engel; Martin Zenke
Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.
Genes & development 1993;7(6):1097-109.
1993: E B Lee; Hartmut Beug; Michael J Hayman
Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.
Oncogene 1993;8(5):1317-27.
1993: D Barettino; T H Bugge; Petr Bartunek; M D Vivanco Ruiz; V Sonntag-Buck; Hartmut Beug; Martin Zenke; Hendrik G Stunnenberg
Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.
The EMBO journal 1993;12(4):1343-54.
1992: G Boehmelt; A Walker; N Kabrun; G Mellitzer; Hartmut Beug; Martin Zenke; P J Enrietto
Hormone-regulated v-rel estrogen receptor fusion protein: reversible induction of cell transformation and cellular gene expression.
The EMBO journal 1992;11(12):4641-52.
1992: J Larsen; Hartmut Beug; Michael J Hayman
The v-ski oncogene cooperates with the v-sea oncogene in erythroid transformation by blocking erythroid differentiation.
Oncogene 1992;7(10):1903-11.
1992: I Killisch; P Steinlein; K Römisch; R Hollinshead; Hartmut Beug; Gareth Griffiths
Characterization of early and late endocytic compartments of the transferrin cycle. Transferrin receptor antibody blocks erythroid differentiation by trapping the receptor in the early endosome.
Journal of cell science 1992;103 ( Pt 1)():211-32.
1992: E Ulrich; G Boehmelt; Adrian Bird; Hartmut Beug
Immortalization of conditionally transformed chicken cells: loss of normal p53 expression is an early step that is independent of cell transformation.
Genes & development 1992;6(5):876-87.
1992: C Schroeder; L Gibson; Martin Zenke; Hartmut Beug
Modulation of normal erythroid differentiation by the endogenous thyroid hormone and retinoic acid receptors: a possible target for v-erbA oncogene action.
Oncogene 1992;7(2):217-27.
1992: C Schroeder; L Gibson; Hartmut Beug
The v-erbA oncogene requires cooperation with tyrosine kinases to arrest erythroid differentiation induced by ligand-activated endogenous c-erbA and retinoic acid receptor.
Oncogene 1992;7(2):203-16.
1991: C Disela; C Glineur; T Bugge; J Sap; G Stengl; J Dodgson; Hendrik G Stunnenberg; Hartmut Beug; Martin Zenke
v-erbA overexpression is required to extinguish c-erbA function in erythroid cell differentiation and regulation of the erbA target gene CAII.
Genes & development 1991;5(11):2033-47.
1991: L E Morrison; G Boehmelt; Hartmut Beug; P J Enrietto
Expression of v-rel in a replication competent virus: transformation and biochemical characterization.
Oncogene 1991;6(9):1657-66.
1990: S Fuerstenberg; Hartmut Beug; M Introna; Khashayarsha Khazaie; A Muñoz; S Ness; K Nordström; J Sap; I Stanley; Martin Zenke
Ectopic expression of the erythrocyte band 3 anion exchange protein, using a new avian retrovirus vector.
Journal of virology 1990;64(12):5891-902.
1990: C Schroeder; C Raynoschek; U Fuhrmann; K Damm; Björn Vennström; Hartmut Beug
The v-erb A oncogene causes repression of erythrocyte-specific genes and an immature, aberrant differentiation phenotype in normal erythroid progenitors.
Oncogene 1990;5(10):1445-53.
1990: C Glineur; Martin Zenke; Hartmut Beug; Jacques Ghysdael
Phosphorylation of the v-erbA protein is required for its function as an oncogene.
Genes & development 1990;4(10):1663-76.
1990: Martin Zenke; A Muñoz; J Sap; Björn Vennström; Hartmut Beug
v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA.
Cell 1990;61(6):1035-49.
1990: D Forrest; A Muñoz; C Raynoschek; Björn Vennström; Hartmut Beug
Requirement for the C-terminal domain of the v-erbA oncogene protein for biological function and transcriptional repression.
Oncogene 1990;5(3):309-16.
1989: U Fuhrmann; Björn Vennström; Hartmut Beug
The mutated, myeloid cell-specific growth factor receptor v-fms transforms avian erythroid but not myeloid cells.
Genes & development 1989;3(12B):2072-82.
1989: Hartmut Beug; T Graf
Co-operation between viral oncogenes in avian erythroid and myeloid leukaemia.
European journal of clinical investigation 1989;19(6):491-502.
1988: Khashayarsha Khazaie; T J Dull; Thomas Graf; J Schlessinger; A Ullrich; Hartmut Beug; Björn Vennström
Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.
The EMBO journal 1988;7(10):3061-71.
1988: Achim Leutz; Hartmut Beug; C Walter; Thomas Graf
Hematopoietic growth factor glycosylation. Multiple forms of chicken myelomonocytic growth factor.
The Journal of biological chemistry 1988;263(8):3905-11.
1988: J Knight; Martin Zenke; C Disela; E Kowenz; P Vogt; James Douglas Engel; M J Hayman; Hartmut Beug
Temperature-sensitive v-sea transformed erythroblasts: a model system to study gene expression during erythroid differentiation.
Genes & development 1988;2(2):247-58.
1988: A Muñoz; Martin Zenke; U Gehring; J Sap; Hartmut Beug; Björn Vennström
Characterization of the hormone-binding domain of the chicken c-erbA/thyroid hormone receptor protein.
The EMBO journal 1988;7(1):155-9.
1988: Thomas Graf; P Kahn; Achim Leutz; Hartmut Beug; Björn Vennström
Cooperativity of viral oncogenes in avian leukaemia.
IARC scientific publications 1988;(92):165-70.
1988: L Frykberg; T Metz; G Brady; M Introna; Hartmut Beug; Björn Vennström; Thomas Graf
A point mutation in the DNA binding domain of the v-myb oncogene of E26 virus confers temperature sensitivity for transformation of myelomonocytic cells.
Oncogene research 1988;3(4):313-22.
1987: S A Ness; Hartmut Beug; Thomas Graf
v-myb dominance over v-myc in doubly transformed chick myelomonocytic cells.
Cell 1987;51(1):41-50.
1987: M Jansson; Hartmut Beug; C Gray; Thomas Graf; Björn Vennström
Defective v-erbB genes can be complemented by v-erbA in erythroblast and fibroblast transformation.
Oncogene 1987;1(2):167-73.
1987: Hartmut Beug; P A Blundell; Thomas Graf
Reversibility of differentiation and proliferative capacity in avian myelomonocytic cells transformed by tsE26 leukemia virus.
Genes & development 1987;1(3):277-86.
1987: K Damm; Hartmut Beug; Thomas Graf; Björn Vennström
A single point mutation in erbA restores the erythroid transforming potential of a mutant avian erythroblastosis virus (AEV) defective in both erbA and erbB oncogenes.
The EMBO journal 1987;6(2):375-82.
1987: E Kowenz; Achim Leutz; G Döderlein; Thomas Graf; Hartmut Beug
ts-oncogene-transformed erythroleukemic cells: a novel test system for purifying and characterizing avian erythroid growth factors.
Haematology and blood transfusion 1987;31():199-209.
1986: J Sap; A Muñoz; K Damm; Y Goldberg; Jacques Ghysdael; Achim Leutz; Hartmut Beug; Björn Vennström
The c-erb-A protein is a high-affinity receptor for thyroid hormone.
Nature 1986;324(6098):635-40.
1986: P Kahn; L Frykberg; C Brady; I Stanley; Hartmut Beug; Björn Vennström; Thomas Graf
v-erbA cooperates with sarcoma oncogenes in leukemic cell transformation.
Cell 1986;45(3):349-56.
1984: Hartmut Beug; Achim Leutz; P Kahn; Thomas Graf
Ts mutants of E26 leukemia virus allow transformed myeloblasts, but not erythroblasts or fibroblasts, to differentiate at the nonpermissive temperature.
Cell 1984;39(3 Pt 2):579-88.
1983: L Frykberg; S Palmieri; Hartmut Beug; Thomas Graf; M J Hayman; Björn Vennström
Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes.
Cell 1983;32(1):227-38.