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Hartmut Beug

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Physiology

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Neoplastic Cell Transformation

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Oncogenes

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Co-Publications
Name
21
Müllner, Ernst
21
von Lindern, Marieke
18
Steinlein, Peter
18
Deiner , Eva Maria
18
Mikulits, Wolfgang
17
Dolznig, Helmut
14
Vennström, Björn
13
Moriggl, Richard
13
Hayman, Michael
12
Graf, Thomas
12
Zenke, Martin
11
Wessely, O
10
Mikula, Mario
10
Kolbus, Andrea
8
Mellitzer, G

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Publications

TOP 3
van Zijl F; Mair M; Csiszar A; Schneller D; Zulehner G; Huber H; Eferl R; Beug H; Dolznig H; Mikulits W
Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge.
Beug Hartmut
Breast cancer stem cells: eradication by differentiation therapy?
Lahsnig C; Mikula M; Petz M; Zulehner G; Schneller D; van Zijl F; Huber H; Csiszar A; Beug H; Mikulits W
ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression.

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All Publications

2009: van Zijl F; Mair M; Csiszar A; Schneller D; Zulehner G; Huber H; Eferl R; Beug H; Dolznig H; Mikulits W
Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge.
Oncogene 2009;28(45):4022-33.
2009: Beug Hartmut
Breast cancer stem cells: eradication by differentiation therapy?
Cell 2009;138(4):623-5.
2009: Lahsnig C; Mikula M; Petz M; Zulehner G; Schneller D; van Zijl F; Huber H; Csiszar A; Beug H; Mikulits W
ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression.
Oncogene 2009;28(5):638-50.
2009: Ecker Andrea; Simma Olivia; Hoelbl Andrea; Kenner Lukas; Beug Hartmut; Moriggl Richard; Sexl Veronika
The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor.
Frontiers in bioscience : a journal and virtual library 2009;14():2944-58.
2008: Kerenyi Marc A; Grebien Florian; Gehart Helmuth; Schifrer Manfred; Artaker Matthias; Kovacic Boris; Beug Hartmut; Moriggl Richard; Müllner Ernst W
Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.
Blood 2008;112(9):3878-88.
2008: Grech Godfrey; Blázquez-Domingo Montserrat; Kolbus Andrea; Bakker Walbert J; Müllner Ernst W; Beug Hartmut; von Lindern Marieke
Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation.
Blood 2008;112(7):2750-60.
2008: Schähs Philipp; Weidinger Petra; Probst Olivia C; Svoboda Barbara; Stadlmann Johannes; Beug Hartmut; Waerner Thomas; Mach Lukas
Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis.
Experimental cell research 2008;314(16):3036-47.
2008: Grebien Florian; Kerenyi Marc A; Kovacic Boris; Kolbe Thomas; Becker Verena; Dolznig Helmut; Pfeffer Klaus; Klingmüller Ursula; Müller Mathias; Beug Hartmut; Müllner Ernst W; Moriggl Richard
Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2.
Blood 2008;111(9):4511-22.
2008: Kornfeld Jan-Wilhelm; Grebien Florian; Kerenyi Marc A; Friedbichler Katrin; Kovacic Boris; Zankl Barbara; Hoelbl Andrea; Nivarti Harini; Beug Hartmut; Sexl Veronika; Muller Mathias; Kenner Lukas; Mullner Ernst W; Gouilleux Fabrice; Moriggl Richard
The different functions of Stat5 and chromatin alteration through Stat5 proteins.
Frontiers in bioscience : a journal and virtual library 2008;13():6237-54.
2007: Aigner K; Dampier B; Descovich L; Mikula M; Sultan A; Schreiber M; Mikulits W; Brabletz T; Strand D; Obrist P; Sommergruber W; Schweifer N; Wernitznig A; Beug H; Foisner R; Eger A
The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.
Oncogene 2007;26(49):6979-88.
2007: Hui Lijian; Bakiri Latifa; Mairhorfer Andreas; Schweifer Norbert; Haslinger Christian; Kenner Lukas; Komnenovic Vukoslav; Scheuch Harald; Beug Hartmut; Wagner Erwin F
p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway.
Nature genetics 2007;39(6):741-9.
2007: Engblom David; Kornfeld Jan-Wilhelm; Schwake Lukas; Tronche Francois; Reimann Andreas; Beug Hartmut; Hennighausen Lothar; Moriggl Richard; Schütz Günther
Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression.
Genes & development 2007;21(10):1157-62.
2007: Rath Oliver; Himmler Adi; Baum Anke; Sommergruber Wolfgang; Beug Hartmut; Metz Thomas
c-Myc is required for transformation of FDC-P1 cells by EGFRvIII.
FEBS letters 2007;581(13):2549-56.
2007: Bakker Walbert J; van Dijk Thamar B; Parren-van Amelsvoort Martine; Kolbus Andrea; Yamamoto Kazuo; Steinlein Peter; Verhaak Roel G W; Mak Tak W; Beug Hartmut; Löwenberg Bob; von Lindern Marieke
Differential regulation of Foxo3a target genes in erythropoiesis.
Molecular and cellular biology 2007;27(10):3839-3854.
2007: Fischer A N M; Fuchs E; Mikula M; Huber H; Beug H; Mikulits W
PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression.
Oncogene 2007;26(23):3395-405.
2007: Aigner Kirsten; Descovich Luise; Mikula Mario; Sultan Aneesa; Dampier Brigitta; Bonné Stefan; van Roy Frans; Mikulits Wolfgang; Schreiber Martin; Brabletz Thomas; Sommergruber Wolfgang; Schweifer Norbert; Wernitznig Andreas; Beug Hartmut; Foisner Roland; Eger Andreas
The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression.
FEBS letters 2007;581(8):1617-24.
2007: Naetar Nana; Hutter Sabine; Dorner Daniela; Dechat Thomas; Korbei Barbara; Gotzmann Josef; Beug Hartmut; Foisner Roland
LAP2alpha-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit.
Journal of cell science 2007;120(Pt 5):737-47.
2007: Harir Noria; Pecquet Christian; Kerenyi Marc; Sonneck Karoline; Kovacic Boris; Nyga Remy; Brevet Marie; Dhennin Isabelle; Gouilleux-Gruart Valerie; Beug Hartmut; Valent Peter; Lassoued Kaiss; Moriggl Richard; Gouilleux Fabrice
Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias.
Blood 2007;109(4):1678-86.
2006: Janda E; Nevolo M; Lehmann K; Downward J; Beug H; Grieco M
Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin.
Oncogene 2006;25(54):7117-30.
2006: Waerner Thomas; Alacakaptan Memetcan; Tamir Ido; Oberauer Rupert; Gal Annamaria; Brabletz Thomas; Schreiber Martin; Jechlinger Martin; Beug Hartmut
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.
Cancer cell 2006;10(3):227-39.
2006: Hernandez-Hernandez Angel; Ray Pampa; Litos Gabi; Ciro Marco; Ottolenghi Sergio; Beug Hartmut; Boyes Joan
Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1.
The EMBO journal 2006;25(14):3264-74.
2006: Kovacic Boris; Stoiber Dagmar; Moriggl Richard; Weisz Eva; Ott René G; Kreibich Rita; Levy David E; Beug Hartmut; Freissmuth Michael; Sexl Veronika
STAT1 acts as a tumor promoter for leukemia development.
Cancer cell 2006;10(1):77-87.
2006: Rubiolo Cristina; Piazzolla Daniela; Meissl Katrin; Beug Hartmut; Huber Johannes C; Kolbus Andrea; Baccarini Manuela
A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation.
Blood 2006;108(1):152-9.
2006: Jechlinger Martin; Sommer Andreas; Moriggl Richard; Seither Peter; Kraut Norbert; Capodiecci Paola; Donovan Michael; Cordon-Cardo Carlos; Beug Hartmut; Grünert Stefan
Autocrine PDGFR signaling promotes mammary cancer metastasis.
The Journal of clinical investigation 2006;116(6):1561-70.
2006: Hoelbl Andrea; Kovacic Boris; Kerenyi Marc A; Simma Olivia; Warsch Wolfgang; Cui Yongzhi; Beug Hartmut; Hennighausen Lothar; Moriggl Richard; Sexl Veronika
Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.
Blood 2006;107(12):4898-906.
2006: Gotzmann J; Fischer A N M; Zojer M; Mikula M; Proell V; Huber H; Jechlinger M; Waerner T; Weith A; Beug H; Mikulits W
A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytes.
Oncogene 2006;25(22):3170-85.
2006: Schranzhofer Matthias; Schifrer Manfred; Cabrera Javier Antonio; Kopp Stephan; Chiba Peter; Beug Hartmut; Müllner Ernst W
Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis.
Blood 2006;107(10):4159-67.
2006: Dolznig H; Grebien F; Deiner E M; Stangl K; Kolbus A; Habermann B; Kerenyi M A; Kieslinger M; Moriggl R; Beug H; Müllner E W
Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR.
Oncogene 2006;25(20):2890-900.
2005: Huber Margit A; Kraut Norbert; Beug Hartmut
Molecular requirements for epithelial-mesenchymal transition during tumor progression.
Current opinion in cell biology 2005;17(5):548-58.
2005: Pilat Sandra; Carotta Sebastian; Schiedlmeier Bernhard; Kamino Kenji; Mairhofer Andreas; Will Elke; Modlich Ute; Steinlein Peter; Ostertag Wolfram; Baum Christopher; Beug Hartmut; Klump Hannes
HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12101-6.
2005: Corvinus Florian M; Orth Carina; Moriggl Richard; Tsareva Svetlana A; Wagner Stefan; Pfitzner Edith B; Baus Daniela; Kaufmann Roland; Huber Lukas A; Zatloukal Kurt; Beug Hartmut; Ohlschläger Peter; Schütz Alexander; Halbhuber Karl-Jürgen; Friedrich Karlheinz
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth.
Neoplasia (New York, N.Y.) 2005;7(6):545-55.
2005: Drissen Roy; von Lindern Marieke; Kolbus Andrea; Driegen Siska; Steinlein Peter; Beug Hartmut; Grosveld Frank; Philipsen Sjaak
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.
Molecular and cellular biology 2005;25(12):5205-14.
2005: Fischer Alexandra N M; Herrera Blanca; Mikula Mario; Proell Verena; Fuchs Eva; Gotzmann Josef; Schulte-Hermann Rolf; Beug Hartmut; Mikulits Wolfgang
Integration of Ras subeffector signaling in TGF-beta mediated late stage hepatocarcinogenesis.
Carcinogenesis 2005;26(5):931-42.
2005: Grebien Florian; Dolznig Helmut; Beug Hartmut; Mullner Ernst W
Cell size control: new evidence for a general mechanism.
Cell cycle (Georgetown, Tex.) 2005;4(3):418-21.
2005: Maschler Sabine; Wirl Gerhard; Spring Herbert; Bredow Dorothea V; Sordat Isabelle; Beug Hartmut; Reichmann Ernst
Tumor cell invasiveness correlates with changes in integrin expression and localization.
Oncogene 2005;24(12):2032-41.
2005: Eger Andreas; Aigner Kirsten; Sonderegger Stefan; Dampier Brigitta; Oehler Susanne; Schreiber Martin; Berx Geert; Cano Amparo; Beug Hartmut; Foisner Roland
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.
Oncogene 2005;24(14):2375-85.
2005: Angelin-Duclos Cristina; Domenget Chantal; Kolbus Andrea; Beug Hartmut; Jurdic Pierre; Samarut Jacques
Thyroid hormone T3 acting through the thyroid hormone alpha receptor is necessary for implementation of erythropoiesis in the neonatal spleen environment in the mouse.
Development (Cambridge, England) 2005;132(5):925-34.
2005: Moriggl Richard; Sexl Veronika; Kenner Lukas; Duntsch Christopher; Stangl Katharina; Gingras Sebastien; Hoffmeyer Angelika; Bauer Anton; Piekorz Roland; Wang Demin; Bunting Kevin D; Wagner Erwin F; Sonneck Karoline; Valent Peter; Ihle James N; Beug Hartmut
Stat5 tetramer formation is associated with leukemogenesis.
Cancer cell 2005;7(1):87-99.
2005: Leberbauer Cornelia; Boulmé Florence; Unfried Gertrud; Huber Johannes; Beug Hartmut; Müllner Ernst W
Different steroids co-regulate long-term expansion versus terminal differentiation in primary human erythroid progenitors.
Blood 2005;105(1):85-94.
2005: Dolznig Helmut; Kolbus Andrea; Leberbauer Cornelia; Schmidt Uwe; Deiner Eva-Maria; Müllner Ernst W; Beug Hartmut
Expansion and differentiation of immature mouse and human hematopoietic progenitors.
Methods in molecular medicine 2005;105():323-44.
2004: Huber Margit A; Beug Hartmut; Wirth Thomas
Epithelial-mesenchymal transition: NF-kappaB takes center stage.
Cell cycle (Georgetown, Tex.) 2004;3(12):1477-80.
2004: Dolznig Helmut; Grebien Florian; Sauer Thomas; Beug Hartmut; Müllner Ernst W
Evidence for a size-sensing mechanism in animal cells.
Nature cell biology 2004;6(9):899-905.
2004: Joosten Marieke; Blázquez-Domingo Montserrat; Lindeboom Fokke; Boulmé Florence; Van Hoven-Beijen Antoinette; Habermann Bianca; Löwenberg Bob; Beug Hartmut; Müllner Ernst W; Delwel Ruud; Von Lindern Marieke
Translational control of putative protooncogene Nm23-M2 by cytokines via phosphoinositide 3-kinase signaling.
The Journal of biological chemistry 2004;279(37):38169-76.
2004: Carotta Sebastian; Pilat Sandra; Mairhofer Andreas; Schmidt Uwe; Dolznig Helmut; Steinlein Peter; Beug Hartmut
Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells.
Blood 2004;104(6):1873-80.
2004: Huber Margit A; Azoitei Ninel; Baumann Bernd; Grünert Stefan; Sommer Andreas; Pehamberger Hubert; Kraut Norbert; Beug Hartmut; Wirth Thomas
NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression.
The Journal of clinical investigation 2004;114(4):569-81.
2004: von Lindern Marieke; Schmidt Uwe; Beug Hartmut
Control of erythropoiesis by erythropoietin and stem cell factor: a novel role for Bruton's tyrosine kinase.
Cell cycle (Georgetown, Tex.) 2004;3(7):876-9.
2004: van den Akker Emile; van Dijk Thamar B; Schmidt Uwe; Felida Lamberto; Beug Hartmut; Löwenberg Bob; von Lindern Marieke
The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity.
Biological chemistry 2004;385(5):409-13.
2004: Maschler Sabine; Grunert Stefan; Danielopol Adriana; Beug Hartmut; Wirl Gerhard
Enhanced tenascin-C expression and matrix deposition during Ras/TGF-beta-induced progression of mammary tumor cells.
Oncogene 2004;23(20):3622-33.
2004: Eger Andreas; Stockinger Andreas; Park John; Langkopf Elke; Mikula Mario; Gotzmann Josef; Mikulits Wolfgang; Beug Hartmut; Foisner Roland
beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition.
Oncogene 2004;23(15):2672-2680.
2004: Tronche François; Opherk Christian; Moriggl Richard; Kellendonk Christoph; Reimann Andreas; Schwake Lukas; Reichardt Holger M; Stangl Katharina; Gau Daniel; Hoeflich Andreas; Beug Hartmut; Schmid Wolfgang; Schütz Günther
Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth.
Genes & development 2004;18(5):492-7.
2004: Schmidt Uwe; van den Akker Emile; Parren-van Amelsvoort Martine; Litos Gabi; de Bruijn Marella; Gutiérrez Laura; Hendriks Rudi W; Ellmeier Wilfried; Löwenberg Bob; Beug Hartmut; von Lindern Marieke
Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.
The Journal of experimental medicine 2004;199(6):785-95.
2004: Mikula Mario; Fuchs Eva; Huber Heidemarie; Beug Hartmut; Schulte-Hermann Rolf; Mikulits Wolfgang
Immortalized p19ARF null hepatocytes restore liver injury and generate hepatic progenitors after transplantation.
Hepatology (Baltimore, Md.) 2004;39(3):628-34.
2004: Bakker Walbert J; Blázquez-Domingo Montserrat; Kolbus Andrea; Besooyen Janey; Steinlein Peter; Beug Hartmut; Coffer Paul J; Löwenberg Bob; von Lindern Marieke; van Dijk Thamar B
FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1.
The Journal of cell biology 2004;164(2):175-84.
2004: Gotzmann Josef; Mikula Mario; Eger Andreas; Schulte-Hermann Rolf; Foisner Roland; Beug Hartmut; Mikulits Wolfgang
Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis.
Mutation research 2004;566(1):9-20.
2003: Dazy Sébastien; Damiola Francesca; Parisey Nicolas; Beug Hartmut; Gandrillon Olivier
The MEK-1/ERKs signalling pathway is differentially involved in the self-renewal of early and late avian erythroid progenitor cells.
Oncogene 2003;22(58):9205-16.
2003: Lebigot Ingrid; Gardellin Paola; Lefebvre Laurent; Beug Hartmut; Ghysdael Jacques; Quang Christine Tran
Up-regulation of SLAP in FLI-1-transformed erythroblasts interferes with EpoR signaling.
Blood 2003;102(13):4555-62.
2003: Kolbus Andrea; Blázquez-Domingo Montserrat; Carotta Sebastian; Bakker Walbert; Luedemann Susanna; von Lindern Marieke; Steinlein Peter; Beug Hartmut
Cooperative signaling between cytokine receptors and the glucocorticoid receptor in the expansion of erythroid progenitors: molecular analysis by expression profiling.
Blood 2003;102(9):3136-46.
2003: Jechlinger Martin; Grunert Stefan; Tamir Ido H; Janda Elzbieta; Lüdemann Susanna; Waerner Thomas; Seither Peter; Weith Andreas; Beug Hartmut; Kraut Norbert
Expression profiling of epithelial plasticity in tumor progression.
Oncogene 2003;22(46):7155-69.
2003: Mikula Mario; Gotzmann Josef; Fischer Alexandra N M; Wolschek Markus F; Thallinger Christiane; Schulte-Hermann Rolf; Beug Hartmut; Mikulits Wolfgang
The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesis.
Oncogene 2003;22(43):6725-38.
2003: Grünert Stefan; Jechlinger Martin; Beug Hartmut
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.
Nature reviews. Molecular cell biology 2003;4(8):657-65.
2002: Kolbus Andrea; Pilat Sandra; Husak Zvenyslava; Deiner Eva Maria; Stengl Gabriele; Beug Hartmut; Baccarini Manuela
Raf-1 antagonizes erythroid differentiation by restraining caspase activation.
The Journal of experimental medicine 2002;196(10):1347-53.
2002: Jechlinger Martin; Grünert Stefan; Beug Hartmut
Mechanisms in epithelial plasticity and metastasis: insights from 3D cultures and expression profiling.
Journal of mammary gland biology and neoplasia 2002;7(4):415-32.
2002: Schulte Cathleen E; von Lindern Marieke; Steinlein Peter; Beug Hartmut; Wiedemann Leanne M
MLL-ENL cooperates with SCF to transform primary avian multipotent cells.
The EMBO journal 2002;21(16):4297-306.
2002: Stroissnigg Heike; Repitz Marion; Miloloza Angelina; Linhartova Irena; Beug Hartmut; Wiche Gerhard; Propst Friedrich
FIP-2, an IkappaB-kinase-gamma-related protein, is associated with the Golgi apparatus and translocates to the marginal band during chicken erythroblast differentiation.
Experimental cell research 2002;278(2):133-45.
2002: Janda Elzbieta; Litos Gabi; Grünert Stefan; Downward Julian; Beug Hartmut
Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway.
Oncogene 2002;21(33):5148-59.
2002: Dolznig Helmut; Habermann Bianca; Stangl Katharina; Deiner Eva Maria; Moriggl Richard; Beug Hartmut; Müllner Ernst W
Apoptosis protection by the Epo target Bcl-X(L) allows factor-independent differentiation of primary erythroblasts.
Current biology : CB 2002;12(13):1076-85.
2002: Vécsey-Semjén Beatrix; Becker Karl-Friedrich; Sinski Alexandra; Blennow Elizabeth; Vietor Ilja; Zatloukal Kurt; Beug Hartmut; Wagner Ernst; Huber Lukas A
Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers.
Oncogene 2002;21(30):4646-62.
2002: Lobmayr Lioba; Sauer Thomas; Killisch Iris; Schranzhofer Matthias; Wilson Robert B; Ponka Prem; Beug Hartmut; Müllner Ernst W
Transferrin receptor hyperexpression in primary erythroblasts is lost on transformation by avian erythroblastosis virus.
Blood 2002;100(1):289-98.
2002: González-Sancho José Manuel; Figueroa Angélica; López-Barahona Mónica; López Eva; Beug Hartmut; Muñoz Alberto
Inhibition of proliferation and expression of T1 and cyclin D1 genes by thyroid hormone in mammary epithelial cells.
Molecular carcinogenesis 2002;34(1):25-34.
2002: Gotzmann Josef; Huber Heidemarie; Thallinger Christiane; Wolschek Markus; Jansen Burkhard; Schulte-Hermann Rolf; Beug Hartmut; Mikulits Wolfgang
Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness.
Journal of cell science 2002;115(Pt 6):1189-202.
2002: Janda Elzbieta; Lehmann Kerstin; Killisch Iris; Jechlinger Martin; Herzig Michaela; Downward Julian; Beug Hartmut; Grünert Stefan
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.
The Journal of cell biology 2002;156(2):299-313.
2001: Stockinger A; Eger A; Wolf J; Beug H; Foisner R
E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity.
The Journal of cell biology 2001;154(6):1185-96.
2001: Czvitkovich S; Sauer S; Peters A H; Deiner E; Wolf A; Laible G; Opravil S; Beug H; Jenuwein T
Over-expression of the SUV39H1 histone methyltransferase induces altered proliferation and differentiation in transgenic mice.
Mechanisms of development 2001;107(1-2):141-53.
2001: Hofmann J F; Sykora M; Redemann N; Beug H
G1-Cdk activity is required for both proliferation and viability of cytokine-dependent myeloid and erythroid cells.
Oncogene 2001;20(31):4198-208.
2001: von Lindern M; Deiner E M; Dolznig H; Parren-Van Amelsvoort M; Hayman M J; Mullner E W; Beug H
Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis.
Oncogene 2001;20(28):3651-64.
2001: Dolznig H; Boulmé F; Stangl K; Deiner E M; Mikulits W; Beug H; Müllner E W
Establishment of normal, terminally differentiating mouse erythroid progenitors: molecular characterization by cDNA arrays.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(8):1442-4.
2001: Mikula M; Schreiber M; Husak Z; Kucerova L; Rüth J; Wieser R; Zatloukal K; Beug H; Wagner E F; Baccarini M
Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene.
The EMBO journal 2001;20(8):1952-62.
2001: Pradet-Balade B; Boulmé F; Beug H; Müllner E W; Garcia-Sanz J A
Translation control: bridging the gap between genomics and proteomics?
Trends in biochemical sciences 2001;26(4):225-9.
2000: Petritsch C; Beug H; Balmain A; Oft M
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest.
Genes & development 2000;14(24):3093-101.
2000: von Lindern M; Parren-van Amelsvoort M; van Dijk T; Deiner E; van den Akker E; van Emst-de Vries S; Willems P; Beug H; Löwenberg B
Protein kinase C alpha controls erythropoietin receptor signaling.
The Journal of biological chemistry 2000;275(44):34719-27.
2000: Lehmann K; Janda E; Pierreux C E; Rytömaa M; Schulze A; McMahon M; Hill C S; Beug H; Downward J
Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells.
Genes & development 2000;14(20):2610-22.
2000: Mikulits W; Schranzhofer M; Deiner E M; Beug H; Müllner E W
Regulation of ferritin mRNA translation in primary erythroblasts: exogenous c-Kit plus EpoR signaling mimics v-ErbA oncoprotein activity.
Biochemical and biophysical research communications 2000;275(2):292-4.
2000: Mikulits W; Pradet-Balade B; Habermann B; Beug H; Garcia-Sanz J A; Müllner E W
Isolation of translationally controlled mRNAs by differential screening.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(11):1641-52.
2000: Ghysdael J; Tran Quang C; Deiner E M; Dolznig H; Müllner E W; Beug H
Erythroid cell development and leukemic transformation: interplay between signal transduction, cell cycle control and oncogenes.
Pathologie-biologie 2000;48(3):211-26.
2000: Kieslinger M; Woldman I; Moriggl R; Hofmann J; Marine J C; Ihle J N; Beug H; Decker T
Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation.
Genes & development 2000;14(2):232-44.
2000: Eger A; Stockinger A; Schaffhauser B; Beug H; Foisner R
Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity.
The Journal of cell biology 2000;148(1):173-88.
1999: Mikulits W; Schranzhofer M; Bauer A; Dolznig H; Lobmayr L; Infante A A; Beug H; Müllner E W
Impaired ferritin mRNA translation in primary erythroid progenitors: shift to iron-dependent regulation by the v-ErbA oncoprotein.
Blood 1999;94(12):4321-32.
1999: Mikulits W; Schranzhofer M; Beug H; Müllner E W
Post-transcriptional control via iron-responsive elements: the impact of aberrations in hereditary disease.
Mutation research 1999;437(3):219-30.
1999: Bauer A; Tronche F; Wessely O; Kellendonk C; Reichardt H M; Steinlein P; Schütz G; Beug H
The glucocorticoid receptor is required for stress erythropoiesis.
Genes & development 1999;13(22):2996-3002.
1999: Oliferenko S; Paiha K; Harder T; Gerke V; Schwärzler C; Schwarz H; Beug H; Günthert U; Huber L A
Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton.
The Journal of cell biology 1999;146(4):843-54.
1999: von Lindern M; Zauner W; Mellitzer G; Steinlein P; Fritsch G; Huber K; Löwenberg B; Beug H
The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro.
Blood 1999;94(2):550-9.
1999: Gandrillon O; Schmidt U; Beug H; Samarut J
TGF-beta cooperates with TGF-alpha to induce the self-renewal of normal erythrocytic progenitors: evidence for an autocrine mechanism.
The EMBO journal 1999;18(10):2764-81.
1999: Jansen M W; von Lindern M; Beug H; Brandenburg H; Wildschut H I; Wladimiroff J W; In 't Veld P A
The use of in vitro expanded erythroid cells in a model system for the isolation of fetal cells from maternal blood.
Prenatal diagnosis 1999;19(4):323-9.
1999: Wessely O; Bauer A; Quang C T; Deiner E M; von Lindern M; Mellitzer G; Steinlein P; Ghysdael J; Beug H
A novel way to induce erythroid progenitor self renewal: cooperation of c-Kit with the erythropoietin receptor.
Biological chemistry 1999;380(2):187-202.
1999: Pereira R; Quang C T; Lesault I; Dolznig H; Beug H; Ghysdael J
FLI-1 inhibits differentiation and induces proliferation of primary erythroblasts.
Oncogene 1999;18(8):1597-608.
1998: Oft M; Heider K H; Beug H
TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis.
Current biology : CB 1998;8(23):1243-52.
1998: Dahl R; Kieslinger M; Beug H; Hayman M J
Transformation of hematopoietic cells by the Ski oncoprotein involves repression of retinoic acid receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11187-92.
1998: Wessely O; Deiner E M; Lim K C; Mellitzer G; Steinlein P; Beug H
Mammalian granulocyte-macrophage colony-stimulating factor receptor expressed in primary avian hematopoietic progenitors: lineage-specific regulation of proliferation and differentiation.
The Journal of cell biology 1998;141(4):1041-51.
1998: von Lindern M; Boer L; Wessely O; Parker M; Beug H
The transactivation domain AF-2 but not the DNA-binding domain of the estrogen receptor is required to inhibit differentiation of avian erythroid progenitors.
Molecular endocrinology (Baltimore, Md.) 1998;12(2):263-77.
1997: Quang C T; Wessely O; Pironin M; Beug H; Ghysdael J
Cooperation of Spi-1/PU.1 with an activated erythropoietin receptor inhibits apoptosis and Epo-dependent differentiation in primary erythroblasts and induces their Kit ligand-dependent proliferation.
The EMBO journal 1997;16(18):5639-53.
1997: Bauer A; Ulrich E; Andersson M; Beug H; von Lindern M
Mechanism of transformation by v-ErbA: substitution for steroid hormone receptor function in self renewal induction.
Oncogene 1997;15(6):701-15.
1997: Mikulits W; Dolznig H; Edelmann H; Sauer T; Deiner E M; Ballou L; Beug H; Müllner E W
Dynamics of cell cycle regulators: artifact-free analysis by recultivation of cells synchronized by centrifugal elutriation.
DNA and cell biology 1997;16(7):849-59.
1997: Woldman I; Mellitzer G; Kieslinger M; Buchhart D; Meinke A; Beug H; Decker T
STAT5 involvement in the differentiation response of primary chicken myeloid progenitor cells to chicken myelomonocytic growth factor.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):877-86.
1997: Wessely O; Mellitzer G; von Lindern M; Levitzki A; Gazit A; Ischenko I; Hayman M J; Beug H
Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(5):481-93.
1997: Wessely O; Deiner E M; Beug H; von Lindern M
The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors.
The EMBO journal 1997;16(2):267-80.
1996: Briegel K; Bartunek P; Stengl G; Lim K C; Beug H; Engel J D; Zenke M
Regulation and function of transcription factor GATA-1 during red blood cell differentiation.
Development (Cambridge, England) 1996;122(12):3839-50.
1996: Beug H; Bauer A; Dolznig H; von Lindern M; Lobmayer L; Mellitzer G; Steinlein P; Wessely O; Mullner E
Avian erythropoiesis and erythroleukemia: towards understanding the role of the biomolecules involved.
Biochimica et biophysica acta 1996;1288(3):M35-47.
1996: Mellitzer G; Wessely O; Decker T; Meinke A; Hayman M J; Beug H
Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9600-5.
1996: Bartunek P; Pichlíková L; Stengl G; Boehmelt G; Martin F H; Beug H; Dvorák M; Zenke M
Avian stem cell factor (SCF): production and characterization of the recombinant His-tagged SCF of chicken and its neutralizing antibody.
Cytokine 1996;8(1):14-20.
1996: Müllner E W; Dolznig H; Beug H
Cell cycle regulation and erythroid differentiation.
Current topics in microbiology and immunology 1996;212():175-94.
1995: Dolznig H; Bartunek P; Nasmyth K; Müllner E W; Beug H
Terminal differentiation of normal chicken erythroid progenitors: shortening of G1 correlates with loss of D-cyclin/cdk4 expression and altered cell size control.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1341-52.
1995: Quang C T; Pironin M; von Lindern M; Beug H; Ghysdael J
Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation control of primary erythroid progenitors.
Oncogene 1995;11(7):1229-39.
1995: Beug H; Schroeder C; Wessely O; Deiner E; Meyer S; Ischenko I D; Hayman M J
Transformation of erythroid progenitors by viral and cellular tyrosine kinases.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(8):999-1008.
1995: Beug H; Dahl R; Steinlein P; Meyer S; Deiner E M; Hayman M J
In vitro growth of factor-dependent multipotential hematopoietic cells is induced by the nuclear oncoprotein v-Ski.
Oncogene 1995;11(1):59-72.
1995: Steinlein P; Wessely O; Meyer S; Deiner E M; Hayman M J; Beug H
Primary, self-renewing erythroid progenitors develop through activation of both tyrosine kinase and steroid hormone receptors.
Current biology : CB 1995;5(2):191-204.
1995: Beug H; Steinlein P; Bartunek P; Hayman M J
Avian hematopoietic cell culture: in vitro model systems to study oncogenic transformation of hematopoietic cells.
Methods in enzymology 1995;254():41-76.
1994: Beug H; Müllner E W; Hayman M J
Insights into erythroid differentiation obtained from studies on avian erythroblastosis virus.
Current opinion in cell biology 1994;6(6):816-24.
1994: Vennström B; Raynoscheck C; Jansson L; Doederlein G; Lhotak V; Johnsson A; Beug H
Retroviral capture of c-erbB proto-oncogene sequences: rapid evolution of distinct viral genomes carrying mutant v-erbB genes with different transforming capacities.
Oncogene 1994;9(5):1307-20.
1994: Steinlein P; Deiner E; Leutz A; Beug H
Recombinant murine erythropoietin receptor expressed in avian erythroid progenitors mediates terminal erythroid differentiation in vitro.
Growth factors (Chur, Switzerland) 1994;10(1):1-16.
1993: Larsen J; Meyer S; Steinlein P; Beug H; Hayman M J
Transformation of chicken bone marrow cells by the v-ski oncogene.
Oncogene 1993;8(12):3221-8.
1993: Hayman M J; Meyer S; Martin F; Steinlein P; Beug H
Self-renewal and differentiation of normal avian erythroid progenitor cells: regulatory roles of the TGF alpha/c-ErbB and SCF/c-kit receptors.
Cell 1993;74(1):157-69.
1993: Briegel K; Lim K C; Plank C; Beug H; Engel J D; Zenke M
Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.
Genes & development 1993;7(6):1097-109.
1993: Lee E B; Beug H; Hayman M J
Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.
Oncogene 1993;8(5):1317-27.
1993: Barettino D; Bugge T H; Bartunek P; Vivanco Ruiz M D; Sonntag-Buck V; Beug H; Zenke M; Stunnenberg H G
Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.
The EMBO journal 1993;12(4):1343-54.
1992: Boehmelt G; Walker A; Kabrun N; Mellitzer G; Beug H; Zenke M; Enrietto P J
Hormone-regulated v-rel estrogen receptor fusion protein: reversible induction of cell transformation and cellular gene expression.
The EMBO journal 1992;11(12):4641-52.
1992: Larsen J; Beug H; Hayman M J
The v-ski oncogene cooperates with the v-sea oncogene in erythroid transformation by blocking erythroid differentiation.
Oncogene 1992;7(10):1903-11.
1992: Killisch I; Steinlein P; Römisch K; Hollinshead R; Beug H; Griffiths G
Characterization of early and late endocytic compartments of the transferrin cycle. Transferrin receptor antibody blocks erythroid differentiation by trapping the receptor in the early endosome.
Journal of cell science 1992;103 ( Pt 1)():211-32.
1992: Ulrich E; Boehmelt G; Bird A; Beug H
Immortalization of conditionally transformed chicken cells: loss of normal p53 expression is an early step that is independent of cell transformation.
Genes & development 1992;6(5):876-87.
1992: Schroeder C; Gibson L; Zenke M; Beug H
Modulation of normal erythroid differentiation by the endogenous thyroid hormone and retinoic acid receptors: a possible target for v-erbA oncogene action.
Oncogene 1992;7(2):217-27.
1992: Schroeder C; Gibson L; Beug H
The v-erbA oncogene requires cooperation with tyrosine kinases to arrest erythroid differentiation induced by ligand-activated endogenous c-erbA and retinoic acid receptor.
Oncogene 1992;7(2):203-16.
1991: Disela C; Glineur C; Bugge T; Sap J; Stengl G; Dodgson J; Stunnenberg H; Beug H; Zenke M
v-erbA overexpression is required to extinguish c-erbA function in erythroid cell differentiation and regulation of the erbA target gene CAII.
Genes & development 1991;5(11):2033-47.
1991: Morrison L E; Boehmelt G; Beug H; Enrietto P J
Expression of v-rel in a replication competent virus: transformation and biochemical characterization.
Oncogene 1991;6(9):1657-66.
1990: Fuerstenberg S; Beug H; Introna M; Khazaie K; Muñoz A; Ness S; Nordström K; Sap J; Stanley I; Zenke M
Ectopic expression of the erythrocyte band 3 anion exchange protein, using a new avian retrovirus vector.
Journal of virology 1990;64(12):5891-902.
1990: Schroeder C; Raynoschek C; Fuhrmann U; Damm K; Vennström B; Beug H
The v-erb A oncogene causes repression of erythrocyte-specific genes and an immature, aberrant differentiation phenotype in normal erythroid progenitors.
Oncogene 1990;5(10):1445-53.
1990: Glineur C; Zenke M; Beug H; Ghysdael J
Phosphorylation of the v-erbA protein is required for its function as an oncogene.
Genes & development 1990;4(10):1663-76.
1990: Zenke M; Muñoz A; Sap J; Vennström B; Beug H
v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA.
Cell 1990;61(6):1035-49.
1990: Forrest D; Muñoz A; Raynoschek C; Vennström B; Beug H
Requirement for the C-terminal domain of the v-erbA oncogene protein for biological function and transcriptional repression.
Oncogene 1990;5(3):309-16.
1989: Fuhrmann U; Vennström B; Beug H
The mutated, myeloid cell-specific growth factor receptor v-fms transforms avian erythroid but not myeloid cells.
Genes & development 1989;3(12B):2072-82.
1989: Beug H; Graf T
Co-operation between viral oncogenes in avian erythroid and myeloid leukaemia.
European journal of clinical investigation 1989;19(6):491-502.
1988: Khazaie K; Dull T J; Graf T; Schlessinger J; Ullrich A; Beug H; Vennström B
Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.
The EMBO journal 1988;7(10):3061-71.
1988: Leutz A; Beug H; Walter C; Graf T
Hematopoietic growth factor glycosylation. Multiple forms of chicken myelomonocytic growth factor.
The Journal of biological chemistry 1988;263(8):3905-11.
1988: Knight J; Zenke M; Disela C; Kowenz E; Vogt P; Engel J D; Hayman M J; Beug H
Temperature-sensitive v-sea transformed erythroblasts: a model system to study gene expression during erythroid differentiation.
Genes & development 1988;2(2):247-58.
1988: Muñoz A; Zenke M; Gehring U; Sap J; Beug H; Vennström B
Characterization of the hormone-binding domain of the chicken c-erbA/thyroid hormone receptor protein.
The EMBO journal 1988;7(1):155-9.
1988: Graf T; Kahn P; Leutz A; Beug H; Vennström B
Cooperativity of viral oncogenes in avian leukaemia.
IARC scientific publications 1988;(92):165-70.
1988: Frykberg L; Metz T; Brady G; Introna M; Beug H; Vennström B; Graf T
A point mutation in the DNA binding domain of the v-myb oncogene of E26 virus confers temperature sensitivity for transformation of myelomonocytic cells.
Oncogene research 1988;3(4):313-22.
1987: Ness S A; Beug H; Graf T
v-myb dominance over v-myc in doubly transformed chick myelomonocytic cells.
Cell 1987;51(1):41-50.
1987: Jansson M; Beug H; Gray C; Graf T; Vennström B
Defective v-erbB genes can be complemented by v-erbA in erythroblast and fibroblast transformation.
Oncogene 1987;1(2):167-73.
1987: Beug H; Blundell P A; Graf T
Reversibility of differentiation and proliferative capacity in avian myelomonocytic cells transformed by tsE26 leukemia virus.
Genes & development 1987;1(3):277-86.
1987: Damm K; Beug H; Graf T; Vennström B
A single point mutation in erbA restores the erythroid transforming potential of a mutant avian erythroblastosis virus (AEV) defective in both erbA and erbB oncogenes.
The EMBO journal 1987;6(2):375-82.
1987: Kowenz E; Leutz A; Döderlein G; Graf T; Beug H
ts-oncogene-transformed erythroleukemic cells: a novel test system for purifying and characterizing avian erythroid growth factors.
Haematology and blood transfusion 1987;31():199-209.
1986: Sap J; Muñoz A; Damm K; Goldberg Y; Ghysdael J; Leutz A; Beug H; Vennström B
The c-erb-A protein is a high-affinity receptor for thyroid hormone.
Nature 1986;324(6098):635-40.
1986: Kahn P; Frykberg L; Brady C; Stanley I; Beug H; Vennström B; Graf T
v-erbA cooperates with sarcoma oncogenes in leukemic cell transformation.
Cell 1986;45(3):349-56.
1984: Beug H; Leutz A; Kahn P; Graf T
Ts mutants of E26 leukemia virus allow transformed myeloblasts, but not erythroblasts or fibroblasts, to differentiate at the nonpermissive temperature.
Cell 1984;39(3 Pt 2):579-88.
1983: Frykberg L; Palmieri S; Beug H; Graf T; Hayman M J; Vennström B
Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes.
Cell 1983;32(1):227-38.

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