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Bruce Beutler

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Eva Marie Y Moresco; Xiaohong Li; Bruce Beutler
Going forward with genetics: recent technological advances and forward genetics in mice.
Roberto Baccala; Bruce Beutler; Amanda L Blasius; Rosana Gonzalez-Quintial; Dwight H Kono; Keiko Ozato; Ivo Rimann; Argyrios N Theofilopoulos
Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus.
Katharina Brandl; Bruce Beutler
Creating diseases to understand what prevents them: genetic analysis of inflammation in the gastrointestinal tract.

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2013: Eva Marie Y Moresco; Xiaohong Li; Bruce Beutler
Going forward with genetics: recent technological advances and forward genetics in mice.
The American journal of pathology 2013;182(5):1462-73.
2013: Roberto Baccala; Bruce Beutler; Amanda L Blasius; Rosana Gonzalez-Quintial; Dwight H Kono; Keiko Ozato; Ivo Rimann; Argyrios N Theofilopoulos
Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):2940-5.
2012: Katharina Brandl; Bruce Beutler
Creating diseases to understand what prevents them: genetic analysis of inflammation in the gastrointestinal tract.
Current opinion in immunology 2012;24(6):678-85.
2012: Owen M Siggs; Bruce Beutler
The BTB-ZF transcription factors.
Cell cycle (Georgetown, Tex.) 2012;11(18):3358-69.
2012: Owen M Siggs; Sophie Rutschmann; Bruce Beutler; Justin T Cruite; Xin Du; Eliezer Masliah; Michael B A Oldstone
Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(34):13733-8.
2012: Katharina Brandl; Werner Falk; Xiaohong Li; Eva Marie Y Moresco; Christina Neppl; Elaine Pirie; Bernd Schnabl; Argyrios N Theofilopoulos; Wataru Tomisato; Yu Xia; Roberto Baccala; Bruce Beutler
Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(31):12650-5.
2012: Carrie N Arnold; Pia Dosenovic; Gunilla B Karlsson Hedestam; Xiaohong Li; Gerald McInerney; Elaine Pirie; Owen M Siggs; Nathaniel Wang; Yu Xia; Bruce Beutler
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(31):12286-93.
2012: Owen M Siggs; Wataru Tomisato; Ying Wang; Yu Xia; Nengming Xiao; Xiaohong Li; Hexin Shi; Bruce Beutler
iRhom2 is required for the secretion of mouse TNFα.
Blood 2012;119(24):5769-71.
2012: Sungyong Won; Carrie N Arnold; Katharina Brandl; Céline Eidenschenk; Eva Marie Y Moresco; Tina-Marie Mullen; Glen R Nemerow; Owen M Siggs; Lei Sun; Bruce Beutler
Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.
Journal of virology 2012;86(3):1802-8.
2012: Emilie Narni-Mancinelli; Frédéric Vely; Eric Vivier; Claire Bernat; Elodie Bertosio; Bruce Beutler; aude de gassart; Jordi Estellé; Aurore Fenis; Louis N Gastinel; Ivo G Gut; Marta Gut; Simon C Heath; Baptiste N Jaeger; Sam Kung; Sajid Mahmood; Bernard Malissen; Marie Malissen; Sophie Ugolini
Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses.
Science (New York, N.Y.) 2012;335(6066):344-8.
2012: Owen M Siggs; Yu Xia; Xiaohong Li; Bruce Beutler
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine 2012;209(1):19-27.
2011: Philippe Krebs; Xiaohong Li; Cecilia Wen Ya Lo; Eva Marie Y Moresco; Jason M Spaeth; Lei Sun; Kimimasa Tobita; Malcolm R Wood; Yu Xia; Jeffrey Yen; Thomas Boyer; Yen-Hui Chen; Ning Ding; Michael R Downes; Ronald M Evans; Weiwei Fan; Bruce Beutler
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(49):19678-82.
2011: Eva Marie Y Moresco; Bruce Beutler
Resisting viral infection: the gene by gene approach.
Current opinion in virology 2011;1(6):513-8.
2011: Eva Marie Y Moresco; Diantha La Vine; Bruce Beutler
Prion-like behavior of MAVS in RIG-I signaling.
Cell research 2011;21(12):1643-5.
2011: Amanda L Blasius; José R Criado; Adrienne E Dubin; Cindy Ehlers; Kirk U Knowlton; Byung-Kwan Lim; Eva Marie Y Moresco; Anna Narezkina; Ardem Patapoutian; Matt J Petrus; Derek N Wills; Yu Xia; Bruce Beutler
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(48):19413-8.
2011: Ioannis Eleftherianos; Jules A Hoffmann; Bruce Beutler; Rolf Bodmer; Stanislava Chtarbanova; Karen Ocorr; Barbara Squiban; Sungyong Won; Jean-Luc Imler
ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(29):12024-9.
2011: Eva Marie Y Moresco; Diantha LaVine; Bruce Beutler
Toll-like receptors.
Current biology : CB 2011;21(13):R488-93.
2011: Daniel E Zak; Bruce Beutler; Alan H Diercks; Shannon G Fallen; Elizabeth S Gold; M Kristina Hamilton; Carrie D Johnson; Kathleen A Kennedy; Antti Niemistö; Jacques J Peschon; Irina Podolsky; Frank Schmitz; Owen M Siggs; Tetyana Stolyar; Rosa Suen; Joe S Valvo; Alan Aderem
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(28):11536-41.
2011: Philippe Krebs; Michael B Oldstone; Daniel Popkin; Karine Crozat; Bruce Beutler
Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice.
Blood 2011;117(24):6582-8.
2011: Owen M Siggs; Bernd Schnabl; Bill Webb; Bruce Beutler
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7890-5.
2011: Owen M Siggs; Carrie N Arnold; Christoph Huber; Elaine Pirie; Yu Xia; Pei Lin; David Nemazee; Bruce Beutler
The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.
Nature immunology 2011;12(5):434-40.
2011: Eva Marie Y Moresco; Bruce Beutler
Special delivery: granulin brings CpG DNA to Toll-like receptor 9.
Immunity 2011;34(4):453-5.
2011: Carlo Iavarone; Katrin Ramsauer; Andriy V Kubarenko; Jason C Debasitis; Igor Leykin; Alexander N R Weber; Owen M Siggs; Bruce Beutler; Pu Zhang; Gillis Otten; Ugo D'Oro; Nicholas Mark Valiante; M Lamine Mbow; Alberto Visintin
A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4213-22.
2011: Daniel L Popkin; John R Teijaro; Brian M Sullivan; Shuzo Urata; Sophie Rutschmann; Juan Carlos de la Torre; Stefan Kunz; Bruce Beutler; Michael Oldstone
Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.
Cell host & microbe 2011;9(3):212-22.
2011: Karine Crozat; Céline Eidenschenk; Baptiste N Jaeger; Philippe Krebs; Sophie Guia; Bruce Beutler; Eric Vivier; Sophie Ugolini
Impact of β2 integrin deficiency on mouse natural killer cell development and function.
Blood 2011;117(10):2874-82.
2011: Steven Beutler; Bruce Beutler
Ernest Beutler: his life and contribution to medical science.
British journal of haematology 2011;152(5):543-50.
2011: Carrie N Arnold; Yu Xia; Pei Lin; Charles Ross; Martin Schwander; Nora G Smart; Ulrich Müller; Bruce Beutler
Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis.
Genetics 2011;187(3):633-41.
2011: Bruce Beutler; Christopher C Goodnow
How host defense is encoded in the mammalian genome.
Mammalian genome : official journal of the International Mammalian Genome Society 2011;22(1-2):1-5.
2010: Monica Guma; Jun-ichi Kashiwakura; Brian Crain; Yuko Kawakami; Bruce Beutler; Gary S Firestein; Toshiaki Kawakami; Michael Karin; Maripat Corr
JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(51):22122-7.
2010: Yu Xia; Sungyong Won; Xin Du; Pei Lin; Charles Ross; Diantha La Vine; Sean Wiltshire; Gabriel Leiva; Silvia M Vidal; Belinda Whittle; Christopher C Goodnow; James Koziol; Eva Marie Y Moresco; Bruce Beutler
Bulk segregation mapping of mutations in closely related strains of mice.
Genetics 2010;186(4):1139-46.
2010: Pamela C Ronald; Bruce Beutler
Plant and animal sensors of conserved microbial signatures.
Science (New York, N.Y.) 2010;330(6007):1061-4.
2010: Amanda L Blasius; Carrie N Arnold; Philippe Georgel; Sophie Rutschmann; Yu Xia; Pei Lin; Charles Ross; Xiaohong Li; Nora G Smart; Bruce Beutler
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):19973-8.
2010: Katharina Brandl; Lei Sun; Christina Neppl; Owen M Siggs; Sylvain M Le Gall; Wataru Tomisato; Xiaohong Li; Xin Du; Daniela N Maennel; Carl P Blobel; Bruce Beutler
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):19967-72.
2010: Zane Orinska; Niko Föger; Michael Huber; Julia Marschall; Farhad Mirghomizadeh; Xin Du; Marina Scheller; Philip Rosenstiel; Torsten Goldmann; Annalena Bollinger; Bruce Beutler; Silvia Bulfone-Paus
I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development.
Blood 2010;116(15):2665-75.
2010: Gerhard Wingender; Philippe Krebs; Bruce Beutler; Mitchell Kronenberg
Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):2721-9.
2010: Céline Eidenschenk; Karine Crozat; Philippe Krebs; Ramon Arens; Daniel Popkin; Carrie N Arnold; Amanda L Blasius; Chris A Benedict; Eva Marie Y Moresco; Yu Xia; Bruce Beutler
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9759-64.
2010: Michael Berger; Philippe Krebs; Karine Crozat; Xiaohong Li; Ben A Croker; Owen M Siggs; Daniel Popkin; Xin Du; Brian R Lawson; Argyrios N Theofilopoulos; Yu Xia; Kevin Khovananth; Eva Marie Moresco; Takashi Satoh; Osamu Takeuchi; Shizuo Akira; Bruce Beutler
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.
Nature immunology 2010;11(4):335-43.
2010: Michael J Barnes; Halil Aksoylar; Philippe Krebs; Tristan Bourdeau; Carrie N Arnold; Yu Xia; Kevin Khovananth; Isaac Engel; Sosathya Sovath; Kristin Lampe; Eleana Laws; Amy Saunders; Geoffrey W Butcher; Mitchell Kronenberg; Kris Steinbrecher; David Hildeman; H Leighton Grimes; Bruce Beutler; Kasper Hoebe
Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3743-54.
2010: Amanda L Blasius; Bruce Beutler
Intracellular toll-like receptors.
Immunity 2010;32(3):305-15.
2010: Argyrios N Theofilopoulos; Rosana Gonzalez-Quintial; Brian R Lawson; yi koh; Michael E Stern; Dwight H Kono; Bruce Beutler; Roberto Baccala
Sensors of the innate immune system: their link to rheumatic diseases.
Nature reviews. Rheumatology 2010;6(3):146-56.
2010: Owen M Siggs; Michael Berger; Philippe Krebs; Carrie N Arnold; Céline Eidenschenk; Christoph Huber; Elaine Pirie; Nora G Smart; Kevin Khovananth; Yu Xia; Gerald McInerney; Gunilla B Karlsson Hedestam; David Nemazee; Bruce Beutler
A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3046-51.
2010: Eva Marie Y Moresco; Bruce Beutler
LGP2: positive about viral sensing.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(4):1261-2.
2010: Mariane B Melo; Pia Kasperkovitz; Anna Cerny; Stephanie Könen-Waisman; Evelyn A Kurt-Jones; Egil Lien; Bruce Beutler; Jonathan C Howard; Douglas T Golenbock; Ricardo T Gazzinelli
UNC93B1 mediates host resistance to infection with Toxoplasma gondii.
PLoS pathogens 2010;6(8):e1001071.
2010: Olivia Osborn; Manuel Sanchez-Alavez; Sara E Brownell; Brendon Ross; Joe Klaus; Jeffrey Dubins; Bruce Beutler; Bruno Conti; Tamas Bartfai
Metabolic characterization of a mouse deficient in all known leptin receptor isoforms.
Cellular and molecular neurobiology 2010;30(1):23-33.
2009: Nengming Xiao; Céline Eidenschenk; Philippe Krebs; Katharina Brandl; Amanda L Blasius; Yu Xia; Kevin Khovananth; Nora G Smart; Bruce Beutler
The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7975-83.
2009: Katharina Flür; Ramanjaneyulu Allam; Daniel Zecher; Onkar P Kulkarni; Julia Lichtnekert; Martin Schwarz; Bruce Beutler; Volker Vielhauer; Hans-Joachim Anders
Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritis.
The American journal of pathology 2009;175(5):2014-22.
2009: Jaroslav Truksa; Terri Gelbart; Hongfan Peng; Ernest Beutler; Bruce Beutler; Pauline Lee
Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6.
British journal of haematology 2009;147(4):571-81.
2009: Roberto Baccala; Rosana Gonzalez-Quintial; Brian R Lawson; Michael E Stern; Dwight H Kono; Bruce Beutler; Argyrios N Theofilopoulos
Sensors of the innate immune system: their mode of action.
Nature reviews. Rheumatology 2009;5(8):448-56.
2009: Emma Slack; Siegfried Hapfelmeier; Bärbel Stecher; Yuliya Velykoredko; Maaike Stoel; Melissa A E Lawson; Markus B Geuking; Bruce Beutler; Thomas F Tedder; Wolf-Dietrich Hardt; Premysl Bercik; Elena F Verdu; Kathy D McCoy; Andrew J Macpherson
Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism.
Science (New York, N.Y.) 2009;325(5940):617-20.
2009: Dwight H Kono; M Katarina Haraldsson; Brian R Lawson; K Michael Pollard; yi koh; Xin Du; Carrie N Arnold; Roberto Baccala; Gregg J Silverman; Bruce Beutler; Argyrios N Theofilopoulos
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12061-6.
2009: Philippe Krebs; Michael J Barnes; Kristin Lampe; Karen Whitley; Keith S Bahjat; Bruce Beutler; Edith Janssen; Kasper Hoebe
NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses.
Blood 2009;113(26):6593-602.
2009: Ryutaro Fukui; Shin-ichiroh Saitoh; Fumi Matsumoto; Hiroko Kozuka-Hata; Masaaki Oyama; Koichi Tabeta; Bruce Beutler; Kensuke Miyake
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.
The Journal of experimental medicine 2009;206(6):1339-50.
2009: Julia Lichtnekert; Volker Vielhauer; Daniel Zecher; Onkar P Kulkarni; Sebastian Clauss; Stephan Segerer; Veit Hornung; Tanya N Mayadas; Bruce Beutler; Shizuo Akira; Hans-Joachim Anders
Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.
American journal of physiology. Renal physiology 2009;296(4):F867-74.
2009: Michael J Barnes; Philippe Krebs; Nathaniel Harris; Celine Eidenschenk; Rosana Gonzalez-Quintial; Carrie N Arnold; Karine Crozat; Sosathya Sovath; Eva Marie Moresco; Argyrios N Theofilopoulos; Bruce Beutler; Kasper Hoebe
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.
PLoS biology 2009;7(3):e51.
2009: Katharina Brandl; Sophie Rutschmann; Xiaohong Li; Xin Du; Nengming Xiao; Bernd Schnabl; David A Brenner; Bruce Beutler
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3300-5.
2009: Amanda L Blasius; Katharina Brandl; Karine Crozat; Yu Xia; Kevin Khovananth; Philippe Krebs; Nora G Smart; Antonella Zampolli; Zaverio M Ruggeri; Bruce Beutler
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2706-11.
2009: Bruce Beutler
TLRs and innate immunity.
Blood 2009;113(7):1399-407.
2009: Bruce Beutler; Jules Hoffmann
What infections actually are.
Journal of innate immunity 2009;1(1):2-3.
2009: Alexandra K Kiemer; Ryan Senaratne; Jessica Hoppstädter; Britta Diesel; Lee W Riley; Koichi Tabeta; Stefan Bauer; Bruce Beutler; Bruce L Zuraw
Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria.
Journal of innate immunity 2009;1(1):29-45.
2009: Maximiliano J Jimenez-Dalmaroni; Nengming Xiao; Adam L Corper; Petra Verdino; Gary D Ainge; Dave S Larsen; Gavin F Painter; Pauline M Rudd; Raymond A Dwek; Kasper Hoebe; Bruce Beutler; Ian A Wilson
Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2.
PloS one 2009;4(10):e7411.
2009: Bruce Beutler
Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases.
Immunological reviews 2009;227(1):248-63.
2009: Bruce Beutler
Obituary: Ernest Beutler (1928-2008).
Haematologica 2009;94(1):154-6.
2008: Agnieszka A Brzezinska; Jennifer L Johnson; Daniela B Munafo; Karine Crozat; Bruce Beutler; William B Kiosses; Beverly A Ellis; Sergio D Catz
The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules.
Traffic (Copenhagen, Denmark) 2008;9(12):2151-64.
2008: Ben A Croker; Brian R Lawson; Sophie Rutschmann; Michael Berger; Celine Eidenschenk; Amanda L Blasius; Eva Marie Y Moresco; Sosathya Sovath; Louise Cengia; Leonard D Shultz; Argyrios N Theofilopoulos; Sven Pettersson; Bruce Beutler
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):15028-33.
2008: Xin Du; Martin Schwander; Eva Marie Y Moresco; Pia Viviani; Claudia Haller; Michael Hildebrand; Kwang Pak; Lisa Tarantino; Amanda Roberts; Heather Richardson; George F Koob; Hossein Najmabadi; Allen F Ryan; Richard J H Smith; Ulrich Müller; Bruce Beutler
A catechol-O-methyltransferase that is essential for auditory function in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14609-14.
2008: Julie Chaix; Marlowe S Tessmer; Kasper Hoebe; Nicolas Fuséri; Bernhard RYFFEL; Marc Dalod; Lena Alexopoulou; Bruce Beutler; Laurent Brossay; Eric Vivier; Thierry Walzer
Cutting edge: Priming of NK cells by IL-18.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1627-31.
2008: Bruce Beutler; I W Milsark; A C Cerami
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science, 1985, 229(4716):869-871. Classical article.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):7-9.
2008: Xin Du; Ellen She; Terri Gelbart; Jaroslav Truksa; Pauline Lee; Yu Xia; Kevin Khovananth; Suzanne Mudd; Navjiwan Mann; Eva Marie Y Moresco; Ernest Beutler; Bruce Beutler
The serine protease TMPRSS6 is required to sense iron deficiency.
Science (New York, N.Y.) 2008;320(5879):1088-92.
2008: Kasper Hoebe; Bruce Beutler
Forward genetic analysis of TLR-signaling pathways: an evaluation.
Advanced drug delivery reviews 2008;60(7):824-9.
2008: Bruce Beutler; E M Y Moresco
The forward genetic dissection of afferent innate immunity.
Current topics in microbiology and immunology 2008;321():3-26.
2008: Bruce Beutler
Immunology, phenotype first. Preface.
Current topics in microbiology and immunology 2008;321():v-viii.
2008: Marina A Freudenberg; Sandrine Tchaptchet; Simone Keck; György Fejer; Michael Huber; Nicole Schütze; Bruce Beutler; Chris Galanos
Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity.
Immunobiology 2008;213(3-4):193-203.
2008: Philippe Georgel; Xin Du; Kasper Hoebe; Bruce Beutler
ENU mutagenesis in mice.
Methods in molecular biology (Clifton, N.J.) 2008;415():1-16.
2008: Bruce Beutler; Eva Marie Y Moresco
Akirins versus infection.
Nature immunology 2008;9(1):7-9.
2007: Ben A Croker; Karine Crozat; Michael Berger; Yu Xia; Sosathya Sovath; Lana Schaffer; Ioannis Eleftherianos; Jean-Luc Imler; Bruce Beutler
ATP-sensitive potassium channels mediate survival during infection in mammals and insects.
Nature genetics 2007;39(12):1453-60.
2007: Bruce Beutler
Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease.
Immunological reviews 2007;220():113-28.
2007: Jadranka Koehn; Dieter Huesken; Markus Jaritz; Antal Rot; Mauro Zurini; Anne Dwertmann; Bruce Beutler; Ulf Korthäuer
Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response.
Human immunology 2007;68(11):871-8.
2007: Bruce Beutler; Céline Eidenschenk; Karine Crozat; Jean-Luc Imler; Osamu Takeuchi; Jules A Hoffmann; Shizuo Akira
Genetic analysis of resistance to viral infection.
Nature reviews. Immunology 2007;7(10):753-66.
2007: Jin-Hwan Han; Shizuo Akira; Kathryn Calame; Bruce Beutler; Erik Selsing; Thereza Imanishi-Kari
Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors.
Immunity 2007;27(1):64-75.
2007: Motoyuki Otsuka; Qing Jing; Philippe Georgel; Liguo New; Jianming Chen; Johann Mols; Young Jun Kang; Zhengfan Jiang; Xin Du; Ryan Cook; Subash C Das; Asit K Pattnaik; Bruce Beutler; Jiahuai Han
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression.
Immunity 2007;27(1):123-34.
2007: Bruce Beutler; Xin Du; Yu Xia
Precis on forward genetics in mice.
Nature immunology 2007;8(7):659-64.
2007: Kristen R Taylor; Kenshi Yamasaki; Katherine A Radek; Anna Di Nardo; Heidi Goodarzi; Douglas T Golenbock; Bruce Beutler; Richard L Gallo
Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2.
The Journal of biological chemistry 2007;282(25):18265-75.
2007: Philippe Georgel; Zhengfan Jiang; Stefan Kunz; edith janssen; Johann Mols; Kasper Hoebe; Seiamak Bahram; Michael B A Oldstone; Bruce Beutler
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.
Virology 2007;362(2):304-13.
2007: Roberto Baccala; Kasper Hoebe; Dwight H Kono; Bruce Beutler; Argyrios N Theofilopoulos
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity.
Nature medicine 2007;13(5):543-51.
2007: Dieudonnée Togbe; Louis Schofield; Georges E Grau; Bruno Schnyder; Victorine Boissay; Sabine Charron; Stéphanie Rose; Bruce Beutler; Valerie QUESNIAUX; Bernhard RYFFEL
Murine cerebral malaria development is independent of toll-like receptor signaling.
The American journal of pathology 2007;170(5):1640-8.
2007: Melanie M Brinkmann; Eric Spooner; Kasper Hoebe; Bruce Beutler; Hidde L Ploegh; you-me kim
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.
The Journal of cell biology 2007;177(2):265-75.
2007: Karine Crozat; Kasper Hoebe; Sophie Ugolini; Nancy A Hong; edith janssen; Sophie Rutschmann; Suzanne Mudd; Sosathya Sovath; Eric Vivier; Bruce Beutler
Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis.
The Journal of experimental medicine 2007;204(4):853-63.
2007: Sung O Kim; Soon-Duck Ha; Sangun Lee; Sarah Stanton; Bruce Beutler; Jiahuai Han
Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells.
BioTechniques 2007;42(4):493-501.
2007: Daniela B Munafó; Jennifer L Johnson; Beverly A Ellis; Sophie Rutschmann; Bruce Beutler; Sergio D Catz
Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes.
The Biochemical journal 2007;402(2):229-39.
2006: Amanda Gavin; Kasper Hoebe; Bao Duong; Takayuki Ota; Christopher Martin; Bruce Beutler; David Nemazee
Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling.
Science (New York, N.Y.) 2006;314(5807):1936-8.
2006: Thomas P Meehan; Koichi Tabeta; Xin Du; Lanette S Woodward; Karen Firozi; Bruce Beutler; Monica J Justice
Point mutations in the melanocortin-4 receptor cause variable obesity in mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2006;17(12):1162-71.
2006: Dieudonnée Togbe; Gorse Aurore; Nicolas Noulin; Valerie QUESNIAUX; Silvia Schnyder-Candrian; Bruno Schnyder; Virginie Vasseur; Shizuo Akira; Kasper Hoebe; Bruce Beutler; Bernhard RYFFEL; Isabelle Couillin
Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways.
Laboratory investigation; a journal of technical methods and pathology 2006;86(11):1126-35.
2006: Armanda Casrouge; Shen-Ying Zhang; Céline Eidenschenk; Emmanuelle Jouanguy; Anne Puel; Kun Yang; Alexandre Alcais; Capucine Picard; Nora Mahfoufi; Nathalie Nicolas; Lazaro LORENZO; Sabine Plancoulaine; Brigitte Sénéchal; Frederic Geissmann; Koichi Tabeta; Kasper Hoebe; Xin Du; Richard L Miller; Bénédicte Héron; Cyril Mignot; Thierry Billette de Villemeur; Pierre Lebon; Olivier Dulac; Flore Rozenberg; Bruce Beutler; Marc Tardieu; Laurent Abel; Jean-Laurent Casanova
Herpes simplex virus encephalitis in human UNC-93B deficiency.
Science (New York, N.Y.) 2006;314(5797):308-12.
2006: Bruce Beutler
Fighting malaria: mosquitoes know how.
Immunity 2006;25(4):530-1.
2006: Yuki Kinjo; Emmanuel Tupin; Douglass Wu; Masakazu Fujio; Raquel Garcia-Navarro; Mohammed Rafii-El-Idrissi Benhnia; Dirk Zajonc; Gil Ben-Menachem; Gary D Ainge; Gavin F Painter; Archana Khurana; Kasper Hoebe; Samuel M Behar; Bruce Beutler; Ian A Wilson; Moriya Tsuji; Timothy J Sellati; Chi-Huey Wong; Mitchell Kronenberg
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
Nature immunology 2006;7(9):978-86.
2006: Zhengfan Jiang; Philippe Georgel; Chenglong Li; Jungwoo Choe; Karine Crozat; Sophie Rutschmann; Xin Du; Tim Bigby; Suzanne Mudd; Sosathya Sovath; Ian A Wilson; Arthur Olson; Bruce Beutler
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10961-6.
2006: Sophie Rutschmann; Kasper Hoebe; Jonathan Zalevsky; Xin Du; Navjiwan Mann; Bassil I Dahiyat; Paul Steed; Bruce Beutler
PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7525-32.
2006: edith janssen; Koichi Tabeta; Michael J Barnes; Sophie Rutschmann; Sara McBride; Keith Bahjat; Stephen P Schoenberger; Argyrios N Theofilopoulos; Bruce Beutler; Kasper Hoebe
Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway.
Immunity 2006;24(6):787-99.
2006: Leonid Gitlin; Winfried Barchet; Susan Gilfillan; Marina Cella; Bruce Beutler; Richard A Flavell; Michael S Diamond; Marco COLONna
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(22):8459-64.
2006: David Nemazee; Amanda Gavin; Kasper Hoebe; Bruce Beutler
Immunology: Toll-like receptors and antibody responses.
Nature 2006;441(7091):E4; discussion E4.
2006: Karine Crozat; Philippe Georgel; Sophie Rutschmann; Navjiwan Mann; Xin Du; Kasper Hoebe; Bruce Beutler
Analysis of the MCMV resistome by ENU mutagenesis.
Mammalian genome : official journal of the International Mammalian Genome Society 2006;17(5):398-406.
2006: Kasper Hoebe; Bruce Beutler
TRAF3: a new component of the TLR-signaling apparatus.
Trends in molecular medicine 2006;12(5):187-9.
2006: Michael Huber; Christoph Kalis; Simone Keck; Zhengfan Jiang; Philippe Georgel; Xin Du; Louis Shamel; Sosathya Sovath; Suzanne Mudd; Bruce Beutler; Chris Galanos; Marina A Freudenberg
R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells.
European journal of immunology 2006;36(3):701-11.
2006: Koichi Tabeta; Kasper Hoebe; edith janssen; Xin Du; Philippe Georgel; Karine Crozat; Suzanne Mudd; Navjiwan Mann; Sosathya Sovath; Jason Goode; Louis Shamel; Anat Herskovits; Daniel A Portnoy; Michael Cooke; Lisa Tarantino; Timothy Wiltshire; Benjamin E Steinberg; Sergio Grinstein; Bruce Beutler
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Nature immunology 2006;7(2):156-64.
2006: Hans Fischer; Masahiro Yamamoto; Shizuo Akira; Bruce Beutler; Catharina Svanborg
Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection.
European journal of immunology 2006;36(2):267-77.
2006: Kasper Hoebe; Zhengfan Jiang; Philippe Georgel; Koichi Tabeta; edith janssen; Xin Du; Bruce Beutler
TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy.
Current pharmaceutical design 2006;12(32):4123-34.
2006: Kasper Hoebe; Zhengfan Jiang; Koichi Tabeta; Xin Du; Philippe Georgel; Karine Crozat; Bruce Beutler
Genetic analysis of innate immunity.
Advances in immunology 2006;91():175-226.
2006: Bruce Beutler; Zhengfan Jiang; Philippe Georgel; Karine Crozat; Ben A Croker; Sophie Rutschmann; Xin Du; Kasper Hoebe
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.
Annual review of immunology 2006;24():353-89.
2005: Xin Du; Koichi Tabeta; Navjiwan Mann; Karine Crozat; Suzanne Mudd; Bruce Beutler
An essential role for Rxr alpha in the development of Th2 responses.
European journal of immunology 2005;35(12):3414-23.
2005: Bruce Beutler; Philippe Georgel; Sophie Rutschmann; Zhengfan Jiang; Ben A Croker; Karine Crozat
Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV).
Briefings in functional genomics & proteomics 2005;4(3):203-13.
2005: Catharina W Wieland; Sandrine Florquin; Nico A Maris; Kasper Hoebe; Bruce Beutler; Kiyoshi Takeda; Shizuo Akira; Tom van der Poll
The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):6042-9.
2005: Philippe Georgel; Karine Crozat; Xavier Lauth; Evgenia Makrantonaki; Holger Seltmann; Sosathya Sovath; Kasper Hoebe; Xin Du; Sophie Rutschmann; Zhengfan Jiang; Timothy Bigby; Victor Nizet; Christos Zouboulis; Bruce Beutler
A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria.
Infection and immunity 2005;73(8):4512-21.
2005: Keun Il Kim; Oxana A Malakhova; Kasper Hoebe; Ming Yan; Bruce Beutler; Dong-Er Zhang
Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):847-54.
2005: Bruce Beutler
The Toll-like receptors: analysis by forward genetic methods.
Immunogenetics 2005;57(6):385-92.
2005: Bruce Beutler; Jean-Laurent Casanova
New frontiers in immunology. Workshop on the road ahead: future directions in fundamental and clinical immunology.
EMBO reports 2005;6(7):620-3.
2005: Zhengfan Jiang; Philippe Georgel; Xin Du; Louis Shamel; Sosathya Sovath; Suzanne Mudd; Michael Huber; Christoph Kalis; Simone Keck; Chris Galanos; Marina A Freudenberg; Bruce Beutler
CD14 is required for MyD88-independent LPS signaling.
Nature immunology 2005;6(6):565-70.
2005: Zuping Zhou; Kasper Hoebe; Xin Du; Zhengfan Jiang; Louis Shamel; Bruce Beutler
Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation.
European journal of immunology 2005;35(6):1918-27.
2005: Kasper Hoebe; Bruce Beutler
Unraveling innate immunity using large scale N-ethyl-N-nitrosourea mutagenesis.
Tissue antigens 2005;65(5):395-401.
2005: Jochen Mattner; Kristin L DeBord; Nahed Ismail; Randal D Goff; Carlos Cantu; Dapeng Zhou; Pierre Saint-Mezard; Vivien Wang; Ying Gao; Ning Yin; Kasper Hoebe; Olaf Schneewind; David Walker; Bruce Beutler; Luc Teyton; Paul B Savage; Albert Bendelac
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections.
Nature 2005;434(7032):525-9.
2005: Thomas R Hawn; Annelies Verbon; Marta Janer; Lue Ping Zhao; Bruce Beutler; Alan Aderem
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2487-9.
2005: Kasper Hoebe; Philippe Georgel; Sophie Rutschmann; Xin Du; Suzanne Mudd; Karine Crozat; Sosathya Sovath; Louis Shamel; Thomas Hartung; Ulrich Zähringer; Bruce Beutler
CD36 is a sensor of diacylglycerides.
Nature 2005;433(7025):523-7.
2005: Bruce Beutler; Karine Crozat; James A Koziol; Philippe Georgel
Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model.
Current opinion in immunology 2005;17(1):36-43.
2005: Bruce Beutler; Kasper Hoebe; Philippe Georgel; Koichi Tabeta; Xin Du
Genetic analysis of innate immunity: identification and function of the TIR adapter proteins.
Advances in experimental medicine and biology 2005;560():29-39.
2005: Argyrios N Theofilopoulos; Roberto Baccala; Bruce Beutler; Dwight H Kono
Type I interferons (alpha/beta) in immunity and autoimmunity.
Annual review of immunology 2005;23():307-36.
2004: Bruce Beutler; Kasper Hoebe; Philippe Georgel; Koichi Tabeta; Xin Du
Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses.
Microbes and infection / Institut Pasteur 2004;6(15):1374-81.
2004: Kasper Hoebe; edith janssen; Bruce Beutler
The interface between innate and adaptive immunity.
Nature immunology 2004;5(10):971-4.
2004: Nicolas Anfossi; Scott H Robbins; Sophie Ugolini; Philippe Georgel; Kasper Hoebe; Cécile Bouneaud; Catherine Ronet; Arthur Kaser; Catherine B DiCioccio; Elena Tomasello; Richard S Blumberg; Bruce Beutler; Steven L Reiner; Lena Alexopoulou; Olivier Lantz; David H Raulet; Laurent Brossay; Eric Vivier
Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3773-82.
2004: Ian Smyth; Xin Du; Martin Taylor; Monica J Justice; Bruce Beutler; Ian J Jackson
The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(37):13560-5.
2004: Bruce Beutler
SHIP, TGF-beta, and endotoxin tolerance.
Immunity 2004;21(2):134-5.
2004: Bruce Beutler
Inferences, questions and possibilities in Toll-like receptor signalling.
Nature 2004;430(6996):257-63.
2004: Bruce Beutler
Toll-like receptors and their place in immunology. Where does the immune response to infection begin?
Nature reviews. Immunology 2004;4(7):498.
2004: Bruce Beutler; Kasper Hoebe; Louis Shamel
Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses.
Comptes rendus biologies 2004;327(6):571-80.
2004: Ernst Th Rietschel; Mireille Rietschel; Bruce Beutler
How the mighty have fallen: fatal infectious diseases of divine composers.
Infectious disease clinics of North America 2004;18(2):311-39, table of contents.
2004: Karine Crozat; Bruce Beutler
TLR7: A new sensor of viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):6835-6.
2004: Koichi Tabeta; Philippe Georgel; edith janssen; Xin Du; Kasper Hoebe; Karine Crozat; Suzanne Mudd; Louis Shamel; Sosathya Sovath; Jason Goode; Lena Alexopoulou; Richard A Flavell; Bruce Beutler
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3516-21.
2004: Heike Weighardt; Gabriela Jusek; Jörg Mages; Roland Lang; Kasper Hoebe; Bruce Beutler; Bernhard Holzmann
Identification of a TLR4- and TRIF-dependent activation program of dendritic cells.
European journal of immunology 2004;34(2):558-64.
2004: Bruce Beutler
Innate immunity: an overview.
Molecular immunology 2004;40(12):845-59.
2004: Kasper Hoebe; Bruce Beutler
LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins.
Journal of endotoxin research 2004;10(2):130-6.
2004: Xin Du; Koichi Tabeta; Kasper Hoebe; Haiquan Liu; Navjiwan Mann; Suzanne Mudd; Karine Crozat; Sosathya Sovath; Xiaohua Gong; Bruce Beutler
Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice.
Genetics 2004;166(1):331-40.
2003: Kasper Hoebe; edith janssen; Sung O Kim; Lena Alexopoulou; Richard A Flavell; Jiahuai Han; Bruce Beutler
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.
Nature immunology 2003;4(12):1223-9.
2003: Thomas R Hawn; Annelies Verbon; Kamilla D Lettinga; Lue Ping Zhao; Shuying Sue Li; Richard J Laws; Shawn J Skerrett; Bruce Beutler; Lea A Schroeder; Alex Nachman; Adrian Ozinsky; Kelly D Smith; Alan Aderem
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.
The Journal of experimental medicine 2003;198(10):1563-72.
2003: Bruce Beutler; Kasper Hoebe; Xin Du; Richard J Ulevitch
How we detect microbes and respond to them: the Toll-like receptors and their transducers.
Journal of leukocyte biology 2003;74(4):479-85.
2003: Kasper Hoebe; Xin Du; Philippe Georgel; edith janssen; Koichi Tabeta; Sung O Kim; Jason Goode; P Lin; Navjiwan Mann; Suzanne Mudd; Karine Crozat; Sosathya Sovath; Jiahuai Han; Bruce Beutler
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.
Nature 2003;424(6950):743-8.
2003: Bruce Beutler
Not "molecular patterns" but molecules.
Immunity 2003;19(2):155-6.
2003: Bruce Beutler; Xin Du; Kasper Hoebe
From phenomenon to phenotype and from phenotype to gene: forward genetics and the problem of sepsis.
The Journal of infectious diseases 2003;187 Suppl 2():S321-6.
2003: Brian J Stevenson; Christian Iseli; Bruce Beutler; Victor Jongeneel
Use of transcriptome data to unravel the fine structure of genes involved in sepsis.
The Journal of infectious diseases 2003;187 Suppl 2():S308-14.
2003: Irina Smirnova; Navjiwan Mann; Annemiek Dols; H H Derkx; Martin L Hibberd; Michael Levin; Bruce Beutler
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6075-80.
2003: Sung O Kim; Qing Jing; Kasper Hoebe; Bruce Beutler; Nicholas S Duesbery; Jiahuai Han
Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha.
The Journal of biological chemistry 2003;278(9):7413-21.
2003: Bruce Beutler
Science review: key inflammatory and stress pathways in critical illness - the central role of the Toll-like receptors.
Critical care (London, England) 2003;7(1):39-46.
2003: Bruce Beutler; Ernst Th Rietschel
Innate immune sensing and its roots: the story of endotoxin.
Nature reviews. Immunology 2003;3(2):169-76.
2003: Bruce Beutler; Kasper Hoebe; Xin Du; edith janssen; Philippe Georgel; Koichi Tabeta
Lps2 and signal transduction in sepsis: at the intersection of host responses to bacteria and viruses.
Scandinavian journal of infectious diseases 2003;35(9):563-7.
2003: Kasper Hoebe; Xin Du; Jason Goode; Navjiwan Mann; Bruce Beutler
Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.
Journal of endotoxin research 2003;9(4):250-5.
2003: Bruce Beutler
Innate immune responses to microbial poisons: discovery and function of the Toll-like receptors.
Annual review of pharmacology and toxicology 2003;43():609-28.
2002: Bruce Beutler; Ernest Beutler
Toll-like receptor 4 polymorphisms and atherogenesis.
The New England journal of medicine 2002;347(24):1978-80; author reply 1978-80.
2002: Bruce Beutler
Endotoxin antagonism: conceptual basis and therapeutic potential.
Expert opinion on therapeutic targets 2002;6(2):147-58.
2002: Bruce Beutler
LPS in microbial pathogenesis: promise and fulfilment.
Journal of endotoxin research 2002;8(5):329-35.
2002: Bruce Beutler
Innate immune sensing of microbial infection: the mechanism and the therapeutic challenge.
Wiener medizinische Wochenschrift (1946) 2002;152(21-22):547-51.
2002: Bruce Beutler
TLR4 as the mammalian endotoxin sensor.
Current topics in microbiology and immunology 2002;270():109-20.
2002: Bruce Beutler; M Rehli
Evolution of the TIR, tolls and TLRs: functional inferences from computational biology.
Current topics in microbiology and immunology 2002;270():1-21.
2002: Bruce Beutler
Toll-like receptors: how they work and what they do.
Current opinion in hematology 2002;9(1):2-10.
2001: Bruce Beutler
Sepsis begins at the interface of pathogen and host.
Biochemical Society transactions 2001;29(Pt 6):853-9.
2001: Irina Smirnova; Martha Hamblin; C McBride; Bruce Beutler; Anna Di Rienzo
Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans.
Genetics 2001;158(4):1657-64.
2001: Bruce Beutler
Autoimmunity and apoptosis: the Crohn's connection.
Immunity 2001;15(1):5-14.
2001: Heinz Redl; A Aderem; Bruce Beutler; T Calandra; J P Mira; Richard J Ulevitch
Clinical expert round table discussion (session 1) at the Margaux Conference on Critical Illness: innate immunity: host recognition of and sensitivity to bacterial components.
Critical care medicine 2001;29(7 Suppl):S19-20.
2001: Bruce Beutler; Alexander Poltorak
Sepsis and evolution of the innate immune response.
Critical care medicine 2001;29(7 Suppl):S2-6; discussion S6-7.
2001: Deborah A Kimbrell; Bruce Beutler
The evolution and genetics of innate immunity.
Nature reviews. Genetics 2001;2(4):256-67.
2001: Bruce Beutler; Alexander Poltorak
The sole gateway to endotoxin response: how LPS was identified as Tlr4, and its role in innate immunity.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(4 Pt 2):474-8.
2001: Bruce Beutler; Xin Du; Alexander Poltorak
Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies.
Journal of endotoxin research 2001;7(4):277-80.
2001: Bruce Beutler; A Poltorak
Toll we meet again....
Nature immunology 2001;2(1):9-10.
2000: X Du; A Poltorak; Y Wei; Bruce Beutler
Three novel mammalian toll-like receptors: gene structure, expression, and evolution.
European cytokine network 2000;11(3):362-71.
2000: Bruce Beutler; A Poltorak
Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response.
European cytokine network 2000;11(2):143-52.
2000: Michael Rehli; A Poltorak; Lucia Schwarzfischer; Stefan W Krause; Reinhard Andreesen; Bruce Beutler
PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene.
The Journal of biological chemistry 2000;275(13):9773-81.
2000: Alexander Poltorak; P Ricciardi-Castagnoli; S Citterio; Bruce Beutler
Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2163-7.
2000: Bruce Beutler
Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity.
Current opinion in microbiology 2000;3(1):23-8.
2000: Bruce Beutler
Tlr4: central component of the sole mammalian LPS sensor.
Current opinion in immunology 2000;12(1):20-6.
2000: Bruce Beutler; Alexander Poltorak
The search for Lps: 1993-1998.
Journal of endotoxin research 2000;6(4):269-93.
2000: Irina Smirnova; Alexander Poltorak; Edward Chan; C McBride; Bruce Beutler
Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4).
Genome biology 2000;1(1):RESEARCH002.
2000: Alexander Poltorak; Irina Smirnova; R Clisch; Bruce Beutler
Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice.
Journal of endotoxin research 2000;6(1):51-6.
2000: J Nattermann; X Du; Y Wei; D Shevchenko; Bruce Beutler
Endotoxin-mimetic effect of antibodies against Toll-like receptor 4.
Journal of endotoxin research 2000;6(3):257-64.
1999: Xin Du; Alexander Poltorak; M Silva; Bruce Beutler
Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor.
Blood cells, molecules & diseases 1999;25(5-6):328-38.
1999: Bruce Beutler
The role of tumor necrosis factor in health and disease.
The Journal of rheumatology. Supplement 1999;57():16-21.
1999: Geri R Brown; G Lindberg; J Meddings; M Silva; Bruce Beutler; D Thiele
Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease.
Gastroenterology 1999;116(3):593-601.
1998: Alexander Poltorak; X He; Irina Smirnova; M Y Liu; Christophe Henri Van Huffel; Xin Du; D Birdwell; E Alejos; M Silva; Chris Galanos; Marina A Freudenberg; P Ricciardi-Castagnoli; B Layton; Bruce Beutler
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.
Science (New York, N.Y.) 1998;282(5396):2085-8.
1998: Geri R Brown; M D Silva; P A Thompson; Bruce Beutler
Lymphoid hyperplasia, CD45RBhigh to CD45RBlow T-cell imbalance, and suppression of Type I diabetes mellitus result from TNF blockade in NOD-->NOD-scid adoptive T cell transfer.
Diabetologia 1998;41(12):1502-10.
1998: Alexander Poltorak; Irina Smirnova; X He; M Y Liu; Christophe Henri Van Huffel; O McNally; D Birdwell; E Alejos; M Silva; Xin Du; P Thompson; Edward Chan; J Ledesma; B Roe; S Clifton; Stefanie N Vogel; Bruce Beutler
Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region.
Blood cells, molecules & diseases 1998;24(3):340-55.
1998: Bruce Beutler; F Bazzoni
TNF, apoptosis and autoimmunity: a common thread?
Blood cells, molecules & diseases 1998;24(2):216-30.
1997: Geri R Brown; Dwain L Thiele; M Silva; Bruce Beutler
Adenoviral vectors given intravenously to immunocompromised mice yield stable transduction of the colonic epithelium.
Gastroenterology 1997;112(5):1586-94.
1996: Bruce Beutler; Robert Munford
Tumor necrosis factor and the Jarisch-Herxheimer reaction.
The New England journal of medicine 1996;335(5):347-8.
1996: F Bazzoni; Bruce Beutler
The tumor necrosis factor ligand and receptor families.
The New England journal of medicine 1996;334(26):1717-25.
1996: M Mohamadzadeh; Alexander Poltorak; P R Bergstressor; Bruce Beutler; Akira Takashima
Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(9):3102-6.
1995: F Bazzoni; E Alejos; Bruce Beutler
Chimeric tumor necrosis factor receptors with constitutive signaling activity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5376-80.
1995: Bruce Beutler
TNF, immunity and inflammatory disease: lessons of the past decade.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 1995;43(3):227-35.
1995: Jay K Kolls; D Lei; Steve Nelson; Warren R Summer; S Greenberg; Bruce Beutler
Adenovirus-mediated blockade of tumor necrosis factor in mice protects against endotoxic shock yet impairs pulmonary host defense.
The Journal of infectious diseases 1995;171(3):570-5.
1995: S de Kossodo; Ponciano D Cruz; I Dougherty; P Thompson; M Silva-Valdez; Bruce Beutler
Expression of the tumor necrosis factor gene by dermal fibroblasts in response to ultraviolet irradiation or lipopolysaccharide.
The Journal of investigative dermatology 1995;104(3):318-22.
1995: R Trüeb; G Brown; Christophe Henri Van Huffel; Alexander Poltorak; M Valdez-Silva; Bruce Beutler
Expression of an adenovirally encoded lymphotoxin-beta inhibitor prevents clearance of Listeria monocytogenes in mice.
Journal of inflammation 1995;45(4):239-47.
1995: F Bazzoni; Bruce Beutler
How do tumor necrosis factor receptors work?
Journal of inflammation 1995;45(4):221-38.
1995: Victor Jongeneel; Bruce Beutler
Genetic polymorphism in the human TNF region: correlation or causation?
Journal of inflammation 1995;46(1):iii-vi.
1995: Bruce Beutler; V Kruys
Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself.
Journal of cardiovascular pharmacology 1995;25 Suppl 2():S1-8.
1995: Alexander Poltorak; F Bazzoni; I I Smirnova; E Alejos; P Thompson; Giamal N Luheshi; N Rothwell; Bruce Beutler
MIP-1 gamma: molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo.
Journal of inflammation 1995;45(3):207-19.
1995: Bruce Beutler
Summary of the 5th International Congress on TNF and related cytokines: scientific advances and their medical applications.
Journal of leukocyte biology 1995;57(1):11-2.
1995: F Bazzoni; Bruce Beutler
Comparative expression of TNF-alpha alleles from normal and autoimmune-prone MHC haplotypes.
Journal of inflammation 1995;45(2):106-14.
1994: TD Geppert; C E Whitehurst; P Thompson; Bruce Beutler
Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway.
Molecular medicine (Cambridge, Mass.) 1994;1(1):93-103.
1994: Bruce Beutler; Christophe Henri Van Huffel
An evolutionary and functional approach to the TNF receptor/ligand family.
Annals of the New York Academy of Sciences 1994;730():118-33.
1994: Bruce Beutler; Christophe Henri Van Huffel
Unraveling function in the TNF ligand and receptor families.
Science (New York, N.Y.) 1994;264(5159):667-8.
1994: Alexander Poltorak; Karsten Peppel; Bruce Beutler
Receptor-mediated label-transfer assay (RELAY): a novel method for the detection of plasma tumor necrosis factor at attomolar concentrations.
Journal of immunological methods 1994;169(1):93-9.
1994: J Kolls; Karsten Peppel; M Silva; Bruce Beutler
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):215-9.
1994: F Bazzoni; Véronique Kruys; A Shakhov; Victor Jongeneel; Bruce Beutler
Analysis of tumor necrosis factor promoter responses to ultraviolet light.
The Journal of clinical investigation 1994;93(1):56-62.
1993: Karsten Peppel; Alexander Poltorak; I Melhado; F Jirik; Bruce Beutler
Expression of a TNF inhibitor in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5699-703.
1993: Y Harel; M Silva; Brett P Giroir; A Weinberg; T B Cleary; Bruce Beutler
A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome.
The Journal of clinical investigation 1993;92(5):2110-6.
1993: Bruce Beutler; G E Grau
Tumor necrosis factor in the pathogenesis of infectious diseases.
Critical care medicine 1993;21(10 Suppl):S423-35.
1993: Bruce Beutler; T Brown
Polymorphism of the mouse TNF-alpha locus: sequence studies of the 3'-untranslated region and first intron.
Gene 1993;129(2):279-83.
1993: Véronique Kruys; P Thompson; Bruce Beutler
Extinction of the tumor necrosis factor locus, and of genes encoding the lipopolysaccharide signaling pathway.
The Journal of experimental medicine 1993;177(5):1383-90.
1993: Bruce Beutler
Cytokines and cancer cachexia.
Hospital practice (Office ed.) 1993;28(4):45-52.
1993: Bruce Beutler
Endotoxin, tumor necrosis factor, and related mediators: new approaches to shock.
New horizons (Baltimore, Md.) 1993;1(1):3-12.
1992: B P Giroir; K Peppel; M Silva; Bruce Beutler
The biosynthesis of tumor necrosis factor during pregnancy: studies with a CAT reporter transgene and TNF inhibitors.
European cytokine network 1992;3(6):533-8.
1992: B P Giroir; J H Johnson; T Brown; G L Allen; Bruce Beutler
The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.
The Journal of clinical investigation 1992;90(3):693-8.
1992: B P Giroir; T Brown; Bruce Beutler
Constitutive synthesis of tumor necrosis factor in the thymus.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4864-8.
1992: B P Giroir; Bruce Beutler
Effect of amrinone on tumor necrosis factor production in endotoxic shock.
Circulatory shock 1992;36(3):200-7.
1992: Bruce Beutler
Application of transcriptional and posttranscriptional reporter constructs to the analysis of tumor necrosis factor gene regulation.
The American journal of the medical sciences 1992;303(2):129-33.
1992: Véronique Kruys; Kathleen A Kemmer; A Shakhov; Victor Jongeneel; Bruce Beutler
Constitutive activity of the tumor necrosis factor promoter is canceled by the 3' untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):673-7.
1991: Karsten Peppel; D Crawford; Bruce Beutler
A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity.
The Journal of experimental medicine 1991;174(6):1483-9.
1991: Justin D Radolf; Michael V Norgard; M E Brandt; R D Isaacs; P A Thompson; Bruce Beutler
Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(6):1968-74.
1991: J H Han; Bruce Beutler; G Huez
Complex regulation of tumor necrosis factor mRNA turnover in lipopolysaccharide-activated macrophages.
Biochimica et biophysica acta 1991;1090(1):22-8.
1991: William H Kutteh; William E Rainey; Bruce Beutler; Bruce R Carr
Tumor necrosis factor-alpha and interleukin-1 beta production by human fetal Kupffer cells.
American journal of obstetrics and gynecology 1991;165(1):112-20.
1991: L S Young; R A Proctor; Bruce Beutler; W R McCabe; J N Sheagren
University of California/Davis Interdepartmental Conference on gram-negative septicemia.
Reviews of infectious diseases 1991;13(4):666-87.
1991: Bruce Beutler; T Brown
A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines.
The Journal of clinical investigation 1991;87(4):1336-44.
1991: J Han; G Huez; Bruce Beutler
Interactive effects of the tumor necrosis factor promoter and 3'-untranslated regions.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1843-8.
1990: Bruce Beutler
TNF in pathophysiology: biosynthetic regulation.
The Journal of investigative dermatology 1990;95(6 Suppl):81S-84S.
1990: Bruce Beutler
A proinflammatory mediator with potential relevance in aging.
Journal of the American Geriatrics Society 1990;38(9):1027-36.
1990: S M Zneimer; D Crawford; Nancy R Schneider; Bruce Beutler
Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization.
Genomics 1990;8(1):175-8.
1990: J Han; P Thompson; Bruce Beutler
Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.
The Journal of experimental medicine 1990;172(1):391-4.
1990: J Han; Bruce Beutler
The essential role of the UA-rich sequence in endotoxin-induced cachectin/TNF synthesis.
European cytokine network 1990;1(2):71-5.
1990: Xavier Sáez-Llorens; Mahmoud M Mustafa; Octavio Ramilo; C Fink; Bruce Beutler; J D Nelson
Tumor necrosis factor alpha and interleukin 1 beta in synovial fluid of infants and children with suppurative arthritis.
American journal of diseases of children (1960) 1990;144(3):353-6.
1990: Octavio Ramilo; Mahmoud M Mustafa; J Porter; Xavier Sáez-Llorens; J Mertsola; K D Olsen; J P Luby; Bruce Beutler; George H McCracken
Detection of interleukin 1 beta but not tumor necrosis factor-alpha in cerebrospinal fluid of children with aseptic meningitis.
American journal of diseases of children (1960) 1990;144(3):349-52.
1990: Bruce Beutler; R J Flower
Consensus and confusion among the Contradas. Molecular and Cellular Biology of IL-1, TNF, and Lipocortins in Inflammation and Differentiation, sponsored by Sclavo Research Center, Siena, Italy, October 22-25, 1989.
The New biologist 1990;2(3):249-53.
1990: Bruce Beutler
The tumor necrosis factors: cachectin and lymphotoxin.
Hospital practice (Office ed.) 1990;25(2):45-56.
1990: J Han; T Brown; Bruce Beutler
Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.
The Journal of experimental medicine 1990;171(2):465-75.
1990: Bruce Beutler
Regulation of cachectin biosynthesis occurs at multiple levels.
Progress in clinical and biological research 1990;349():229-40.
1990: Véronique Kruys; Bruce Beutler; G Huez
Translational control mediated by UA-rich sequences.
Enzyme 1990;44(1-4):193-202.
1990: Bruce Beutler
The complex regulation and biology of TNF (cachectin).
Critical reviews in oncogenesis 1990;2(1):9-18.
1989: D Crawford; K Hagerty; Bruce Beutler
Multiple splice forms of ribonuclease-inhibitor mRNA differ in the 5'-untranslated region.
Gene 1989;85(2):525-31.
1989: Valeria Rettori; L Milenkovic; Bruce Beutler; S M McCann
Hypothalamic action of cachectin to alter pituitary hormone release.
Brain research bulletin 1989;23(6):471-5.
1989: Mahmoud M Mustafa; Octavio Ramilo; J Mertsola; RC Risser; Bruce Beutler; E J Hansen; G H McCracken
Modulation of inflammation and cachectin activity in relation to treatment of experimental Hemophilus influenzae type b meningitis.
The Journal of infectious diseases 1989;160(5):818-25.
1989: Mahmoud M Mustafa; Octavio Ramilo; K D Olsen; P S Franklin; E J Hansen; Bruce Beutler; George H McCracken
Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis.
The Journal of clinical investigation 1989;84(4):1253-9.
1989: Károly Cseh; Bruce Beutler
Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein.
The Journal of biological chemistry 1989;264(27):16256-60.
1989: U Pauli; Bruce Beutler; Ernst Peterhans
Porcine tumor necrosis factor alpha: cloning with the polymerase chain reaction and determination of the nucleotide sequence.
Gene 1989;81(1):185-91.
1989: Mahmoud M Mustafa; M H Lebel; Octavio Ramilo; K D Olsen; J S Reisch; Bruce Beutler; George H McCracken
Correlation of interleukin-1 beta and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis.
The Journal of pediatrics 1989;115(2):208-13.
1989: K Takayama; N Qureshi; Bruce Beutler; Theo N Kirkland
Diphosphoryl lipid A from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide.
Infection and immunity 1989;57(4):1336-8.
1989: Bruce Beutler
Cachectin in tissue injury, shock, and related states.
Critical care clinics 1989;5(2):353-67.
1989: L Milenkovic; Valeria Rettori; G D Snyder; Bruce Beutler; S M McCann
Cachectin alters anterior pituitary hormone release by a direct action in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2418-22.
1989: Bruce Beutler
Cachexia: a basic biochemical mechanism.
Nutrition (Burbank, Los Angeles County, Calif.) 1989;5(2):129-31.
1989: ML Casey; Susan M Cox; Bruce Beutler; L Milewich; PC MacDonald
Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor.
The Journal of clinical investigation 1989;83(2):430-6.
1989: Bruce Beutler
Orchestration of septic shock by cytokines: the role of cachectin (tumor necrosis factor).
Progress in clinical and biological research 1989;286():219-35.
1989: Bruce Beutler; A Cerami
The biology of cachectin/TNF--a primary mediator of the host response.
Annual review of immunology 1989;7():625-55.
1989: E Beutler; Terri Gelbart; J H Han; J A Koziol; Bruce Beutler
Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):192-6.
1988: M Huber; Bruce Beutler; Dietrich Keppler
Tumor necrosis factor alpha stimulates leukotriene production in vivo.
European journal of immunology 1988;18(12):2085-8.
1988: Bruce Beutler
Cachexia: a fundamental mechanism.
Nutrition reviews 1988;46(11):369-73.
1988: Bruce Beutler; A Cerami
The history, properties, and biological effects of cachectin.
Biochemistry 1988;27(20):7575-82.
1988: Michael J Eck; Bruce Beutler; G Kuo; J P Merryweather; Stephen R Sprang
Crystallization of trimeric recombinant human tumor necrosis factor (cachectin).
The Journal of biological chemistry 1988;263(26):12816-9.
1988: Bruce Beutler
The presence of cachectin/tumor necrosis factor in human disease states.
The American journal of medicine 1988;85(3):287-8.
1988: Bruce Beutler; P Thompson; J Keyes; K Hagerty; D Crawford
Assay of a ribonuclease that preferentially hydrolyses mRNAs containing cytokine-derived UA-rich instability sequences.
Biochemical and biophysical research communications 1988;152(3):973-80.
1988: Kevin Tracey; H Wei; K R Manogue; Yuman Fong; D G Hesse; H T Nguyen; G C Kuo; Bruce Beutler; R S Cotran; A Cerami
Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.
The Journal of experimental medicine 1988;167(3):1211-27.
1988: Bruce Beutler; A Cerami
Cachectin (tumor necrosis factor): a macrophage hormone governing cellular metabolism and inflammatory response.
Endocrine reviews 1988;9(1):57-66.
1988: S D Wolpe; G Davatelis; Barbara Sherry; Bruce Beutler; D G Hesse; H T Nguyen; L L Moldawer; C F Nathan; Stephen F Lowry; Anthony Cerami
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties.
The Journal of experimental medicine 1988;167(2):570-81.
1988: Steven H Zuckerman; Y M Surprenant; D G Carlson; Bruce Beutler
Restoration of the lipopolysaccharide-responsive phenotype in C3H/HeJ peritoneal macrophage-P388D1 cell hybrids.
Journal of leukocyte biology 1988;43(2):133-9.
1988: Bruce Beutler; A Cerami
Cachectin, cachexia, and shock.
Annual review of medicine 1988;39():75-83.
1988: A Cerami; Bruce Beutler
The role of cachectin/TNF in endotoxic shock and cachexia.
Immunology today 1988;9(1):28-31.
1988: Bruce Beutler; A Cerami
Tumor necrosis, cachexia, shock, and inflammation: a common mediator.
Annual review of biochemistry 1988;57():505-18.
1988: Bruce Beutler; A Cerami
The common mediator of shock, cachexia, and tumor necrosis.
Advances in immunology 1988;42():213-31.
1987: Bruce Beutler; A Cerami
Cachectin--Tumour necrosis factor: a cytokine that mediates injury initiated by invasive parasites.
Parasitology today (Personal ed.) 1987;3(11):345-6.
1987: Kevin Tracey; Stephen F Lowry; T J Fahey; J D Albert; Yuman Fong; D Hesse; Bruce Beutler; K R Manogue; S Calvano; H Wei
Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog.
Surgery, gynecology & obstetrics 1987;164(5):415-22.
1987: Bruce Beutler; A Cerami
The endogenous mediator of endotoxic shock.
Clinical research 1987;35(3):192-7.
1987: Bruce Beutler; A Cerami
Cachectin: more than a tumor necrosis factor.
The New England journal of medicine 1987;316(7):379-85.
1987: A Cerami; Kevin Tracey; S F Lowry; Bruce Beutler
Cachectin: a pluripotent hormone released during the host response to invasion.
Recent progress in hormone research 1987;43():99-112.
1986: Bruce Beutler; V Tkacenko; I Milsark; N Krochin; A Cerami
Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype.
The Journal of experimental medicine 1986;164(5):1791-6.
1986: Kevin Tracey; Bruce Beutler; Stephen F Lowry; J Merryweather; S Wolpe; I W Milsark; R J Hariri; T J Fahey; A Zentella; J D Albert
Shock and tissue injury induced by recombinant human cachectin.
Science (New York, N.Y.) 1986;234(4775):470-4.
1986: Kevin Tracey; S F Lowry; Bruce Beutler; A Cerami; J D Albert; G T Shires
Cachectin/tumor necrosis factor mediates changes of skeletal muscle plasma membrane potential.
The Journal of experimental medicine 1986;164(4):1368-73.
1986: C A Dinarello; Joseph Cannon; S M Wolff; H A Bernheim; Bruce Beutler; A Cerami; I S Figari; M A Palladino; J V O'Connor
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.
The Journal of experimental medicine 1986;163(6):1433-50.
1986: Bruce Beutler; N Krochin; I W Milsark; C Luedke; A Cerami
Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance.
Science (New York, N.Y.) 1986;232(4753):977-80.
1986: Bruce Beutler; A Cerami
Cachectin and tumour necrosis factor as two sides of the same biological coin.
Nature 1986;320(6063):584-8.
1986: D Caput; Bruce Beutler; K Hartog; R Thayer; S Brown-Shimer; A Cerami
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1670-4.
1986: A Cerami; Bruce Beutler
Cachectin: the dark side of tumor necrosis factor.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():625-9.
1986: Bruce Beutler; A Cerami
Cachectin/tumor necrosis factor: an endogenous mediator of shock and inflammation.
Immunologic research 1986;5(4):281-93.
1985: J M Dayer; Bruce Beutler; A Cerami
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.
The Journal of experimental medicine 1985;162(6):2163-8.
1985: Bruce Beutler; I W Milsark; A Cerami
Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(6):3972-7.
1985: Bruce Beutler; A Cerami
Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(6):3969-71.
1985: Bruce Beutler; I W Milsark; A C Cerami
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.
Science (New York, N.Y.) 1985;229(4716):869-71.
1985: F M Torti; B Dieckmann; Bruce Beutler; A Cerami; G M Ringold
A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia.
Science (New York, N.Y.) 1985;229(4716):867-9.
1985: Bruce Beutler; D Greenwald; J D Hulmes; M Chang; Y C Pan; John C Mathison; R Ulevitch; A Cerami
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin.
Nature 1985;316(6028):552-4.
1985: Bruce Beutler; J Mahoney; N Le Trang; P Pekala; A Cerami
Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.
The Journal of experimental medicine 1985;161(5):984-95.
1985: J R Mahoney; Bruce Beutler; N Le Trang; W Vine; Y Ikeda; M Kawakami; A Cerami
Lipopolysaccharide-treated RAW 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(3):1673-5.
1985: A Cerami; Y Ikeda; N Le Trang; P J Hotez; Bruce Beutler
Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: the role of cachectin (tumor necrosis factor).
Immunology letters 1985;11(3-4):173-7.
1982: Bruce Beutler; K Stefansson; B G Arnason
A biochemically distinct sub-population of neurons in the human substantia gelatinosa. Study with G-6-PD histochemistry.
Journal of the neurological sciences 1982;55(2):175-83.
1981: Bruce Beutler; A B Noronha; M M Poon; B G Arnason
The absence of unique kainic acid-like molecules in urine, serum, and CSF from Huntington's disease patients.
Journal of the neurological sciences 1981;51(3):355-60.
1978: Bruce Beutler; Y Nagai; S Ohno; G Klein; I M Shapiro
The HLA-dependent expression of testis- organizing H-Y antigen by human male cells.
Cell 1978;13(3):509-13.
1975: E Beutler; Bruce Beutler; J Matsumoto
Glutathione peroxidase activity of inorganic selenium and seleno-DL-cysteine.
Experientia 1975;31(7):769-70.
1974: E Beutler; C West; Bruce Beutler
Electrophoretic polymorphism of glutathione peroxidase.
Annals of human genetics 1974;38(2):163-9.