Bruce Beutler

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Truksa Jaroslav; Gelbart Terri; Peng Hongfan; Beutler Ernest; Beutler Bruce; Lee Pauline
Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6.
Baccala Roberto; Gonzalez-Quintial Rosana; Lawson Brian R; Stern Michael E; Kono Dwight H; Beutler Bruce; Theofilopoulos Argyrios N
Sensors of the innate immune system: their mode of action.
Kono Dwight H; Haraldsson M Katarina; Lawson Brian R; Pollard K Michael; Koh Yi Ting; Du Xin; Arnold Carrie N; Baccala Roberto; Silverman Gregg J; Beutler Bruce A; Theofilopoulos Argyrios N
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus.

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All Publications

2009: Truksa Jaroslav; Gelbart Terri; Peng Hongfan; Beutler Ernest; Beutler Bruce; Lee Pauline
Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6.
British journal of haematology 2009;147(4):571-81.
2009: Baccala Roberto; Gonzalez-Quintial Rosana; Lawson Brian R; Stern Michael E; Kono Dwight H; Beutler Bruce; Theofilopoulos Argyrios N
Sensors of the innate immune system: their mode of action.
Nature reviews. Rheumatology 2009;5(8):448-56.
2009: Kono Dwight H; Haraldsson M Katarina; Lawson Brian R; Pollard K Michael; Koh Yi Ting; Du Xin; Arnold Carrie N; Baccala Roberto; Silverman Gregg J; Beutler Bruce A; Theofilopoulos Argyrios N
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12061-6.
2009: Krebs Philippe; Barnes Michael J; Lampe Kristin; Whitley Karen; Bahjat Keith S; Beutler Bruce; Janssen Edith; Hoebe Kasper
NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses.
Blood 2009;113(26):6593-602.
2009: Barnes Michael J; Krebs Philippe; Harris Nathaniel; Eidenschenk Celine; Gonzalez-Quintial Rosana; Arnold Carrie N; Crozat Karine; Sovath Sosathya; Moresco Eva Marie; Theofilopoulos Argyrios N; Beutler Bruce; Hoebe Kasper
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.
PLoS biology 2009;7(3):e51.
2009: Brandl Katharina; Rutschmann Sophie; Li Xiaohong; Du Xin; Xiao Nengming; Schnabl Bernd; Brenner David A; Beutler Bruce
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3300-5.
2009: Beutler Bruce
Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases.
Immunological reviews 2009;227(1):248-63.
2009: Beutler Bruce
Obituary: Ernest Beutler (1928-2008).
Haematologica 2009;94(1):154-6.
2008: Brzezinska Agnieszka A; Johnson Jennifer L; Munafo Daniela B; Crozat Karine; Beutler Bruce; Kiosses William B; Ellis Beverly A; Catz Sergio D
The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules.
Traffic (Copenhagen, Denmark) 2008;9(12):2151-64.
2008: Croker Ben A; Lawson Brian R; Rutschmann Sophie; Berger Michael; Eidenschenk Celine; Blasius Amanda L; Moresco Eva Marie Y; Sovath Sosathya; Cengia Louise; Shultz Leonard D; Theofilopoulos Argyrios N; Pettersson Sven; Beutler Bruce Alan
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):15028-33.
2008: Du Xin; Schwander Martin; Moresco Eva Marie Y; Viviani Pia; Haller Claudia; Hildebrand Michael S; Pak Kwang; Tarantino Lisa; Roberts Amanda; Richardson Heather; Koob George; Najmabadi Hossein; Ryan Allen F; Smith Richard J H; Müller Ulrich; Beutler Bruce
A catechol-O-methyltransferase that is essential for auditory function in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14609-14.
2008: Chaix Julie; Tessmer Marlowe S; Hoebe Kasper; Fuséri Nicolas; Ryffel Bernhard; Dalod Marc; Alexopoulou Lena; Beutler Bruce; Brossay Laurent; Vivier Eric; Walzer Thierry
Cutting edge: Priming of NK cells by IL-18.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1627-31.
2008: Du Xin; She Ellen; Gelbart Terri; Truksa Jaroslav; Lee Pauline; Xia Yu; Khovananth Kevin; Mudd Suzanne; Mann Navjiwan; Moresco Eva Marie Y; Beutler Ernest; Beutler Bruce
The serine protease TMPRSS6 is required to sense iron deficiency.
Science (New York, N.Y.) 2008;320(5879):1088-92.
2008: Beutler Bruce; Moresco Eva Marie Y
Akirins versus infection.
Nature immunology 2008;9(1):7-9.
2008: Beutler B; Moresco E M Y
The forward genetic dissection of afferent innate immunity.
Current topics in microbiology and immunology 2008;321():3-26.
2007: Croker Ben; Crozat Karine; Berger Michael; Xia Yu; Sovath Sosathya; Schaffer Lana; Eleftherianos Ioannis; Imler Jean-Luc; Beutler Bruce
ATP-sensitive potassium channels mediate survival during infection in mammals and insects.
Nature genetics 2007;39(12):1453-60.
2007: Beutler Bruce
Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease.
Immunological reviews 2007;220():113-28.
2007: Beutler Bruce; Eidenschenk Celine; Crozat Karine; Imler Jean-Luc; Takeuchi Osamu; Hoffmann Jules A; Akira Shizuo
Genetic analysis of resistance to viral infection.
Nature reviews. Immunology 2007;7(10):753-66.
2007: Otsuka Motoyuki; Jing Qing; Georgel Philippe; New Liguo; Chen Jianming; Mols Johann; Kang Young Jun; Jiang Zhengfan; Du Xin; Cook Ryan; Das Subash C; Pattnaik Asit K; Beutler Bruce; Han Jiahuai
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression.
Immunity 2007;27(1):123-34.
2007: Beutler Bruce; Du Xin; Xia Yu
Precis on forward genetics in mice.
Nature immunology 2007;8(7):659-64.
2007: Georgel Philippe; Jiang Zhengfan; Kunz Stefan; Janssen Edith; Mols Johann; Hoebe Kasper; Bahram Siamak; Oldstone Michael B A; Beutler Bruce
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.
Virology 2007;362(2):304-13.
2007: Baccala Roberto; Hoebe Kasper; Kono Dwight H; Beutler Bruce; Theofilopoulos Argyrios N
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity.
Nature medicine 2007;13(5):543-51.
2007: Crozat Karine; Hoebe Kasper; Ugolini Sophie; Hong Nancy A; Janssen Edith; Rutschmann Sophie; Mudd Suzanne; Sovath Sosathya; Vivier Eric; Beutler Bruce
Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis.
The Journal of experimental medicine 2007;204(4):853-63.
2007: Munafó Daniela B; Johnson Jennifer L; Ellis Beverly A; Rutschmann Sophie; Beutler Bruce; Catz Sergio D
Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes.
The Biochemical journal 2007;402(2):229-39.
2006: Gavin Amanda L; Hoebe Kasper; Duong Bao; Ota Takayuki; Martin Christopher; Beutler Bruce; Nemazee David
Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling.
Science (New York, N.Y.) 2006;314(5807):1936-8.
2006: Meehan Thomas P; Tabeta Koichi; Du Xin; Woodward Lanette S; Firozi Karen; Beutler Bruce; Justice Monica J
Point mutations in the melanocortin-4 receptor cause variable obesity in mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2006;17(12):1162-71.
2006: Beutler Bruce
Fighting malaria: mosquitoes know how.
Immunity 2006;25(4):530-1.
2006: Casrouge Armanda; Zhang Shen-Ying; Eidenschenk Céline; Jouanguy Emmanuelle; Puel Anne; Yang Kun; Alcais Alexandre; Picard Capucine; Mahfoufi Nora; Nicolas Nathalie; Lorenzo Lazaro; Plancoulaine Sabine; Sénéchal Brigitte; Geissmann Frédéric; Tabeta Koichi; Hoebe Kasper; Du Xin; Miller Richard L; Héron Bénédicte; Mignot Cyril; de Villemeur Thierry Billette; Lebon Pierre; Dulac Olivier; Rozenberg Flore; Beutler Bruce; Tardieu Marc; Abel Laurent; Casanova Jean-Laurent
Herpes simplex virus encephalitis in human UNC-93B deficiency.
Science (New York, N.Y.) 2006;314(5797):308-12.
2006: Jiang Zhengfan; Georgel Philippe; Li Chenglong; Choe Jungwoo; Crozat Karine; Rutschmann Sophie; Du Xin; Bigby Tim; Mudd Suzanne; Sovath Sosathya; Wilson Ian A; Olson Arthur; Beutler Bruce
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10961-6.
2006: Janssen Edith; Tabeta Koichi; Barnes Michael J; Rutschmann Sophie; McBride Sara; Bahjat Keith S; Schoenberger Stephen P; Theofilopoulos Argyrios N; Beutler Bruce; Hoebe Kasper
Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway.
Immunity 2006;24(6):787-99.
2006: Rutschmann Sophie; Hoebe Kasper; Zalevsky Jonathan; Du Xin; Mann Navjiwan; Dahiyat Bassil I; Steed Paul; Beutler Bruce
PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7525-32.
2006: Nemazee D; Gavin A; Hoebe K; Beutler B
Immunology: Toll-like receptors and antibody responses.
Nature 2006;441(7091):E4; discussion E4.
2006: Crozat Karine; Georgel Philippe; Rutschmann Sophie; Mann Navjiwan; Du Xin; Hoebe Kasper; Beutler Bruce
Analysis of the MCMV resistome by ENU mutagenesis.
Mammalian genome : official journal of the International Mammalian Genome Society 2006;17(5):398-406.
2006: Hoebe Kasper; Beutler Bruce
TRAF3: a new component of the TLR-signaling apparatus.
Trends in molecular medicine 2006;12(5):187-9.
2006: Huber Michael; Kalis Christoph; Keck Simone; Jiang Zhengfan; Georgel Philippe; Du Xin; Shamel Louis; Sovath Sosathya; Mudd Suzanne; Beutler Bruce; Galanos Chris; Freudenberg Marina A
R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells.
European journal of immunology 2006;36(3):701-11.
2006: Tabeta Koichi; Hoebe Kasper; Janssen Edith M; Du Xin; Georgel Philippe; Crozat Karine; Mudd Suzanne; Mann Navjiwan; Sovath Sosathya; Goode Jason; Shamel Louis; Herskovits Anat A; Portnoy Daniel A; Cooke Michael; Tarantino Lisa M; Wiltshire Tim; Steinberg Benjamin E; Grinstein Sergio; Beutler Bruce
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Nature immunology 2006;7(2):156-64.
2006: Hoebe K; Jiang Z; Georgel P; Tabeta K; Janssen E; Du X; Beutler B
TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy.
Current pharmaceutical design 2006;12(32):4123-34.
2006: Hoebe Kasper; Jiang Zhengfan; Tabeta Koichi; Du Xin; Georgel Philippe; Crozat Karine; Beutler Bruce
Genetic analysis of innate immunity.
Advances in immunology 2006;91():175-226.
2006: Beutler Bruce; Jiang Zhengfan; Georgel Philippe; Crozat Karine; Croker Ben; Rutschmann Sophie; Du Xin; Hoebe Kasper
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.
Annual review of immunology 2006;24():353-89.
2005: Du Xin; Tabeta Koichi; Mann Navjiwan; Crozat Karine; Mudd Suzanne; Beutler Bruce
An essential role for Rxr alpha in the development of Th2 responses.
European journal of immunology 2005;35(12):3414-23.
2005: Beutler Bruce; Georgel Philippe; Rutschmann Sophie; Jiang Zhengfan; Croker Ben; Crozat Karine
Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV).
Briefings in functional genomics & proteomics 2005;4(3):203-13.
2005: Georgel Philippe; Crozat Karine; Lauth Xavier; Makrantonaki Evgenia; Seltmann Holger; Sovath Sosathya; Hoebe Kasper; Du Xin; Rutschmann Sophie; Jiang Zhengfan; Bigby Timothy; Nizet Victor; Zouboulis Christos C; Beutler Bruce
A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria.
Infection and immunity 2005;73(8):4512-21.
2005: Kim Keun Il; Malakhova Oxana A; Hoebe Kasper; Yan Ming; Beutler Bruce; Zhang Dong-Er
Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):847-54.
2005: Beutler Bruce
The Toll-like receptors: analysis by forward genetic methods.
Immunogenetics 2005;57(6):385-92.
2005: Beutler Bruce; Casanova Jean-Laurent
New frontiers in immunology. Workshop on the road ahead: future directions in fundamental and clinical immunology.
EMBO reports 2005;6(7):620-3.
2005: Jiang Zhengfan; Georgel Philippe; Du Xin; Shamel Louis; Sovath Sosathya; Mudd Suzanne; Huber Michael; Kalis Christoph; Keck Simone; Galanos Chris; Freudenberg Marina; Beutler Bruce
CD14 is required for MyD88-independent LPS signaling.
Nature immunology 2005;6(6):565-70.
2005: Zhou Zuping; Hoebe Kasper; Du Xin; Jiang Zhengfan; Shamel Louis; Beutler Bruce
Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation.
European journal of immunology 2005;35(6):1918-27.
2005: Hoebe K; Beutler B
Unraveling innate immunity using large scale N-ethyl-N-nitrosourea mutagenesis.
Tissue antigens 2005;65(5):395-401.
2005: Hoebe Kasper; Georgel Philippe; Rutschmann Sophie; Du Xin; Mudd Suzanne; Crozat Karine; Sovath Sosathya; Shamel Louis; Hartung Thomas; Zähringer Ulrich; Beutler Bruce
CD36 is a sensor of diacylglycerides.
Nature 2005;433(7025):523-7.
2005: Beutler Bruce; Crozat Karine; Koziol James A; Georgel Philippe
Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model.
Current opinion in immunology 2005;17(1):36-43.
2005: Beutler Bruce; Hoebe Kasper; Georgel Philippe; Tabeta Koichi; Du Xin
Genetic analysis of innate immunity: identification and function of the TIR adapter proteins.
Advances in experimental medicine and biology 2005;560():29-39.
2005: Theofilopoulos Argyrios N; Baccala Roberto; Beutler Bruce; Kono Dwight H
Type I interferons (alpha/beta) in immunity and autoimmunity.
Annual review of immunology 2005;23():307-36.
2004: Beutler Bruce; Hoebe Kasper; Georgel Philippe; Tabeta Koichi; Du Xin
Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses.
Microbes and infection / Institut Pasteur 2004;6(15):1374-81.
2004: Hoebe Kasper; Janssen Edith; Beutler Bruce
The interface between innate and adaptive immunity.
Nature immunology 2004;5(10):971-4.
2004: Anfossi Nicolas; Robbins Scott H; Ugolini Sophie; Georgel Philippe; Hoebe Kasper; Bouneaud Cécile; Ronet Catherine; Kaser Arthur; DiCioccio Catherine B; Tomasello Elena; Blumberg Richard S; Beutler Bruce; Reiner Steven L; Alexopoulou Lena; Lantz Olivier; Raulet David H; Brossay Laurent; Vivier Eric
Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3773-82.
2004: Beutler Bruce
SHIP, TGF-beta, and endotoxin tolerance.
Immunity 2004;21(2):134-5.
2004: Beutler Bruce
Toll-like receptors and their place in immunology. Where does the immune response to infection begin?
Nature reviews. Immunology 2004;4(7):498.
2004: Beutler Bruce
Inferences, questions and possibilities in Toll-like receptor signalling.
Nature 2004;430(6996):257-63.
2004: Beutler Bruce; Hoebe Kasper; Shamel Louis
Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses.
Comptes rendus biologies 2004;327(6):571-80.
2004: Crozat K; Beutler B
TLR7: A new sensor of viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):6835-6.
2004: Tabeta Koichi; Georgel Philippe; Janssen Edith; Du Xin; Hoebe Kasper; Crozat Karine; Mudd Suzanne; Shamel Louis; Sovath Sosathya; Goode Jason; Alexopoulou Lena; Flavell Richard A; Beutler Bruce
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3516-21.
2004: Beutler Bruce
Innate immunity: an overview.
Molecular immunology 2004;40(12):845-59.
2004: Du Xin; Tabeta Koichi; Hoebe Kasper; Liu Haiquan; Mann Navjiwan; Mudd Suzanne; Crozat Karine; Sovath Sosathya; Gong Xiaohua; Beutler Bruce
Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice.
Genetics 2004;166(1):331-40.
2004: Hoebe Kasper; Beutler Bruce
LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins.
Journal of endotoxin research 2004;10(2):130-6.
2003: Hoebe Kasper; Janssen Edith M; Kim Sung O; Alexopoulou Lena; Flavell Richard A; Han Jiahuai; Beutler Bruce
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.
Nature immunology 2003;4(12):1223-9.
2003: Beutler B; Hoebe K; Du X; Ulevitch R J
How we detect microbes and respond to them: the Toll-like receptors and their transducers.
Journal of leukocyte biology 2003;74(4):479-85.
2003: Beutler Bruce
Not "molecular patterns" but molecules.
Immunity 2003;19(2):155-6.
2003: Hoebe K; Du X; Georgel P; Janssen E; Tabeta K; Kim S O; Goode J; Lin P; Mann N; Mudd S; Crozat K; Sovath S; Han J; Beutler B
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.
Nature 2003;424(6950):743-8.
2003: Beutler Bruce; Du Xin; Hoebe Kasper
From phenomenon to phenotype and from phenotype to gene: forward genetics and the problem of sepsis.
The Journal of infectious diseases 2003;187 Suppl 2():S321-6.
2003: Smirnova Irina; Mann Navjiwan; Dols Annemiek; Derkx H H; Hibberd Martin L; Levin Michael; Beutler Bruce
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6075-80.
2003: Beutler Bruce
Science review: key inflammatory and stress pathways in critical illness - the central role of the Toll-like receptors.
Critical care (London, England) 2003;7(1):39-46.
2003: Beutler Bruce; Rietschel Ernst Th
Innate immune sensing and its roots: the story of endotoxin.
Nature reviews. Immunology 2003;3(2):169-76.
2003: Kim Sung O; Jing Qing; Hoebe Kasper; Beutler Bruce; Duesbery Nicholas S; Han Jiahuai
Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha.
The Journal of biological chemistry 2003;278(9):7413-21.
2003: Beutler Bruce; Hoebe Kasper; Du Xin; Janssen Edith; Georgel Philippe; Tabeta Koichi
Lps2 and signal transduction in sepsis: at the intersection of host responses to bacteria and viruses.
Scandinavian journal of infectious diseases 2003;35(9):563-7.
2003: Hoebe Kasper; Du Xin; Goode Jason; Mann Navjiwan; Beutler Bruce
Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.
Journal of endotoxin research 2003;9(4):250-5.
2003: Beutler Bruce
Innate immune responses to microbial poisons: discovery and function of the Toll-like receptors.
Annual review of pharmacology and toxicology 2003;43():609-28.
2002: Beutler Bruce
Endotoxin antagonism: conceptual basis and therapeutic potential.
Expert opinion on therapeutic targets 2002;6(2):147-58.
2002: Beutler Bruce
LPS in microbial pathogenesis: promise and fulfilment.
Journal of endotoxin research 2002;8(5):329-35.
2002: Beutler B
TLR4 as the mammalian endotoxin sensor.
Current topics in microbiology and immunology 2002;270():109-20.
2002: Beutler B; Rehli M
Evolution of the TIR, tolls and TLRs: functional inferences from computational biology.
Current topics in microbiology and immunology 2002;270():1-21.
2001: Beutler B
Sepsis begins at the interface of pathogen and host.
Biochemical Society transactions 2001;29(Pt 6):853-9.
2001: Smirnova I; Hamblin M T; McBride C; Beutler B; Di Rienzo A
Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans.
Genetics 2001;158(4):1657-64.
2001: Beutler B
Autoimmunity and apoptosis: the Crohn's connection.
Immunity 2001;15(1):5-14.
2001: Beutler B; Poltorak A
Sepsis and evolution of the innate immune response.
Critical care medicine 2001;29(7 Suppl):S2-6; discussion S6-7.
2001: Beutler B; Poltorak A
The sole gateway to endotoxin response: how LPS was identified as Tlr4, and its role in innate immunity.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(4 Pt 2):474-8.
2001: Beutler B; Du X; Poltorak A
Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies.
Journal of endotoxin research 2001;7(4):277-80.
2000: Poltorak A; Ricciardi-Castagnoli P; Citterio S; Beutler B
Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2163-7.
2000: Beutler B
Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity.
Current opinion in microbiology 2000;3(1):23-8.
2000: Beutler B
Tlr4: central component of the sole mammalian LPS sensor.
Current opinion in immunology 2000;12(1):20-6.
2000: Beutler B; Poltorak A
The search for Lps: 1993-1998.
Journal of endotoxin research 2000;6(4):269-93.
2000: Smirnova I; Poltorak A; Chan E K; McBride C; Beutler B
Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4).
Genome biology 2000;1(1):RESEARCH002.
2000: Poltorak A; Smirnova I; Clisch R; Beutler B
Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice.
Journal of endotoxin research 2000;6(1):51-6.
1999: Du X; Poltorak A; Silva M; Beutler B
Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor.
Blood cells, molecules & diseases 1999;25(5-6):328-38.
1998: Poltorak A; He X; Smirnova I; Liu M Y; Van Huffel C; Du X; Birdwell D; Alejos E; Silva M; Galanos C; Freudenberg M; Ricciardi-Castagnoli P; Layton B; Beutler B
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.
Science (New York, N.Y.) 1998;282(5396):2085-8.
1998: Poltorak A; Smirnova I; He X; Liu M Y; Van Huffel C; McNally O; Birdwell D; Alejos E; Silva M; Du X; Thompson P; Chan E K; Ledesma J; Roe B; Clifton S; Vogel S N; Beutler B
Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region.
Blood cells, molecules & diseases 1998;24(3):340-55.
1998: Beutler B; Bazzoni F
TNF, apoptosis and autoimmunity: a common thread?
Blood cells, molecules & diseases 1998;24(2):216-30.
1996: Bazzoni F; Beutler B
The tumor necrosis factor ligand and receptor families.
The New England journal of medicine 1996;334(26):1717-25.
1996: Mohamadzadeh M; Poltorak A N; Bergstressor P R; Beutler B; Takashima A
Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(9):3102-6.
1995: Bazzoni F; Alejos E; Beutler B
Chimeric tumor necrosis factor receptors with constitutive signaling activity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5376-80.
1995: de Kossodo S; Cruz P D; Dougherty I; Thompson P; Silva-Valdez M; Beutler B
Expression of the tumor necrosis factor gene by dermal fibroblasts in response to ultraviolet irradiation or lipopolysaccharide.
The Journal of investigative dermatology 1995;104(3):318-22.
1995: Trüeb R; Brown G; Van Huffel C; Poltorak A; Valdez-Silva M; Beutler B
Expression of an adenovirally encoded lymphotoxin-beta inhibitor prevents clearance of Listeria monocytogenes in mice.
Journal of inflammation 1995;45(4):239-47.
1995: Poltorak A N; Bazzoni F; Smirnova I I; Alejos E; Thompson P; Luheshi G; Rothwell N; Beutler B
MIP-1 gamma: molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo.
Journal of inflammation 1995;45(3):207-19.
1995: Bazzoni F; Beutler B
Comparative expression of TNF-alpha alleles from normal and autoimmune-prone MHC haplotypes.
Journal of inflammation 1995;45(2):106-14.
1994: Geppert T D; Whitehurst C E; Thompson P; Beutler B
Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway.
Molecular medicine (Cambridge, Mass.) 1994;1(1):93-103.
1994: Beutler B; Van Huffel C
An evolutionary and functional approach to the TNF receptor/ligand family.
Annals of the New York Academy of Sciences 1994;730():118-33.
1994: Beutler B; van Huffel C
Unraveling function in the TNF ligand and receptor families.
Science (New York, N.Y.) 1994;264(5159):667-8.
1994: Poltorak A; Peppel K; Beutler B
Receptor-mediated label-transfer assay (RELAY): a novel method for the detection of plasma tumor necrosis factor at attomolar concentrations.
Journal of immunological methods 1994;169(1):93-9.
1994: Bazzoni F; Kruys V; Shakhov A; Jongeneel C V; Beutler B
Analysis of tumor necrosis factor promoter responses to ultraviolet light.
The Journal of clinical investigation 1994;93(1):56-62.
1994: Kolls J; Peppel K; Silva M; Beutler B
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):215-9.
1993: Harel Y; Silva M; Giroir B; Weinberg A; Cleary T B; Beutler B
A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome.
The Journal of clinical investigation 1993;92(5):2110-6.
1993: Peppel K; Poltorak A; Melhado I; Jirik F; Beutler B
Expression of a TNF inhibitor in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5699-703.
1993: Kruys V; Thompson P; Beutler B
Extinction of the tumor necrosis factor locus, and of genes encoding the lipopolysaccharide signaling pathway.
The Journal of experimental medicine 1993;177(5):1383-90.
1992: Beutler B
Application of transcriptional and posttranscriptional reporter constructs to the analysis of tumor necrosis factor gene regulation.
The American journal of the medical sciences 1992;303(2):129-33.
1992: Kruys V; Kemmer K; Shakhov A; Jongeneel V; Beutler B
Constitutive activity of the tumor necrosis factor promoter is canceled by the 3' untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):673-7.
1991: Peppel K; Crawford D; Beutler B
A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity.
The Journal of experimental medicine 1991;174(6):1483-9.
1991: Radolf J D; Norgard M V; Brandt M E; Isaacs R D; Thompson P A; Beutler B
Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(6):1968-74.
1991: Beutler B; Brown T
A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines.
The Journal of clinical investigation 1991;87(4):1336-44.
1991: Han J; Huez G; Beutler B
Interactive effects of the tumor necrosis factor promoter and 3'-untranslated regions.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1843-8.
1990: Beutler B
TNF in pathophysiology: biosynthetic regulation.
The Journal of investigative dermatology 1990;95(6 Suppl):81S-84S.
1990: Han J; Thompson P; Beutler B
Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.
The Journal of experimental medicine 1990;172(1):391-4.
1990: Han J; Brown T; Beutler B
Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.
The Journal of experimental medicine 1990;171(2):465-75.
1990: Kruys V; Beutler B; Huez G
Translational control mediated by UA-rich sequences.
Enzyme 1990;44(1-4):193-202.
1990: Beutler B
The complex regulation and biology of TNF (cachectin).
Critical reviews in oncogenesis 1990;2(1):9-18.
1989: Rettori V; Milenkovic L; Beutler B A; McCann S M
Hypothalamic action of cachectin to alter pituitary hormone release.
Brain research bulletin 1989;23(6):471-5.
1989: Mustafa M M; Ramilo O; Olsen K D; Franklin P S; Hansen E J; Beutler B; McCracken G H
Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis.
The Journal of clinical investigation 1989;84(4):1253-9.
1989: Cseh K; Beutler B
Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein.
The Journal of biological chemistry 1989;264(27):16256-60.
1989: Beutler B
Cachectin in tissue injury, shock, and related states.
Critical care clinics 1989;5(2):353-67.
1989: Milenkovic L; Rettori V; Snyder G D; Beutler B; McCann S M
Cachectin alters anterior pituitary hormone release by a direct action in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2418-22.
1989: Beutler B; Cerami A
The biology of cachectin/TNF--a primary mediator of the host response.
Annual review of immunology 1989;7():625-55.
1988: Beutler B; Cerami A
The history, properties, and biological effects of cachectin.
Biochemistry 1988;27(20):7575-82.
1988: Eck M J; Beutler B; Kuo G; Merryweather J P; Sprang S R
Crystallization of trimeric recombinant human tumor necrosis factor (cachectin).
The Journal of biological chemistry 1988;263(26):12816-9.

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