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Christoph Rader

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Publications

TOP 3
Joshua D Thomas; Huiting Cui; Thomas Hofer; Patrick J North; Christoph Rader; Terrence R Burke
Application of strain-promoted azide-alkyne cycloaddition and tetrazine ligation to targeted Fc-drug conjugates.
Huiting Cui; Terrence R Burke; Joshua D Thomas; Christoph Rader
Chemically programmed bispecific antibodies that recruit and activate T cells.
Sivasubramanian Baskar; Ira Pastan; Adrian Wiestner; Wyndham H Wilson; Christoph Rader
Targeting malignant B cells with an immunotoxin against ROR1.

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All Publications

2012: Joshua D Thomas; Huiting Cui; Thomas Hofer; Patrick J North; Christoph Rader; Terrence R Burke
Application of strain-promoted azide-alkyne cycloaddition and tetrazine ligation to targeted Fc-drug conjugates.
Bioconjugate chemistry 2012;23(10):2007-13.
2012: Huiting Cui; Terrence R Burke; Joshua D Thomas; Christoph Rader
Chemically programmed bispecific antibodies that recruit and activate T cells.
The Journal of biological chemistry 2012;287(34):28206-14.
2012: Sivasubramanian Baskar; Ira Pastan; Adrian Wiestner; Wyndham H Wilson; Christoph Rader
Targeting malignant B cells with an immunotoxin against ROR1.
mAbs 2012;4(3):349-61.
2012: Hema Dave; Javed Khan; ALAN WAYNE; Miriam R Anver; Sivasubramanian Baskar; Patrick Brown; Donna O Butcher; Christoph Rader
Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies.
PloS one 2012;7(12):e52655.
2012: Jiahui Yang; Christoph Rader
Cloning, expression, and purification of monoclonal antibodies in scFv-Fc format.
Methods in molecular biology (Clifton, N.J.) 2012;901():209-32.
2012: Christoph Rader
Selection of human Fab libraries by phage display.
Methods in molecular biology (Clifton, N.J.) 2012;901():81-99.
2012: Christoph Rader
Generation of human Fab libraries for phage display.
Methods in molecular biology (Clifton, N.J.) 2012;901():53-79.
2011: Davide Bagnara; Matthew Kaufman; Carlo Calissano; Sonia Marsilio; Piers E M Patten; Rita Simone; Philip Chum; Joy (Xiao-Jie) Yan; Steven Allen; Jonathan E Kolitz; Sivasubramanian Baskar; Christoph Rader; Hakan Mellstedt; Hodjattallah Rabbani; Annette Lee; Peter K Gregersen; Kanti R Rai; Nicholas Chiorazzi
A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease.
Blood 2011;117(20):5463-72.
2011: Mitchell Ho; Mingqian Feng; Robert J Fisher; Christoph Rader; Ira Pastan
A novel high-affinity human monoclonal antibody to mesothelin.
International journal of cancer. Journal international du cancer 2011;128(9):2020-30.
2011: Jiahui Yang; Adrian Wiestner; Sivasubramanian Baskar; Michael G Kennedy; Ka Yin Kwong; Christoph Rader
Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies.
PloS one 2011;6(6):e21018.
2010: Michael Hudecek; Thomas M Schmitt; Sivasubramanian Baskar; Maria Teresa Lupo-Stanghellini; Tetsuya Nishida; Tori N Yamamoto; Marie Bleakley; Cameron J Turtle; Wen-Chung Chang; Harvey A Greisman; Brent Wood; David G Maloney; Michael C Jensen; Christoph Rader; Stanley R Riddell
The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.
Blood 2010;116(22):4532-41.
2010: Erica Salerno; Yao Yuan; Brian J Scaglione; Gerald E Marti; Alexander Jankovic; Fermina Mazzella; Maria Fernanda Laurindo; Daryl Despres; Sivasubramanian Baskar; Christoph Rader; Elizabeth Raveche
The New Zealand black mouse as a model for the development and progression of chronic lymphocytic leukemia.
Cytometry. Part B, Clinical cytometry 2010;78 Suppl 1():S98-109.
2009: Thomas Hofer; Lauren R Skeffington; Colby M Chapman; Christoph Rader
Molecularly defined antibody conjugation through a selenocysteine interface.
Biochemistry 2009;48(50):12047-57.
2009: Sivasubramanian Baskar; Jessica M Suschak; Ivan Samija; Ramaprasad Srinivasan; Richard W Childs; Steven Z Pavletic; Michael Bishop; Christoph Rader
A human monoclonal antibody drug and target discovery platform for B-cell chronic lymphocytic leukemia based on allogeneic hematopoietic stem cell transplantation and phage display.
Blood 2009;114(20):4494-502.
2009: Christoph Rader
Overview on concepts and applications of Fab antibody fragments.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2009;Chapter 6():Unit 6.9.
2009: Ka Yin Kwong; Christoph Rader
E. coli expression and purification of Fab antibody fragments.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2009;Chapter 6():Unit 6.10.
2009: Christoph Rader
Generation and selection of rabbit antibody libraries by phage display.
Methods in molecular biology (Clifton, N.J.) 2009;525():101-28, xiv.
2008: Ka Yin Kwong; Sivasubramanian Baskar; Hua Zhang; CRYSTAL MACKALL; Christoph Rader
Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity.
Journal of molecular biology 2008;384(5):1143-56.
2008: Joshua D Thomas; Thomas Hofer; Christoph Rader; Terrence R Burke
Application of a trifunctional reactive linker for the construction of antibody-drug hybrid conjugates.
Bioorganic & medicinal chemistry letters 2008;18(21):5785-8.
2008: Thomas Hofer; Joshua D Thomas; Terrence R Burke; Christoph Rader
An engineered selenocysteine defines a unique class of antibody derivatives.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12451-6.
2008: Sivasubramanian Baskar; Ka Yin Kwong; Thomas Hofer; Jessica M Levy; Michael G Kennedy; Elinor Lee; Louis M Staudt; Wyndham H Wilson; Adrian Wiestner; Christoph Rader
Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):396-404.
2008: Roman J Giger; Karthik Venkatesh; Onanong Chivatakarn; Stephen J Raiker; Laurie Robak; Thomas Hofer; Hakjoo Lee; Christoph Rader
Mechanisms of CNS myelin inhibition: evidence for distinct and neuronal cell type specific receptor systems.
Restorative neurology and neuroscience 2008;26(2-3):97-115.
2007: Sunny Abraham; Fang Guo; Lian-Sheng Li; Christoph Rader; Cheng Liu; Carlos F Barbas; Richard A Lerner; Subhash C Sinha
Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5584-9.
2007: Thomas Hofer; Wisit Tangkeangsirisin; Michael G Kennedy; Rose G Mage; Stephen J Raiker; Karthik Venkatesh; Hakjoo Lee; Roman J Giger; Christoph Rader
Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector.
Journal of immunological methods 2007;318(1-2):75-87.
2006: Mikhail Popkov; Christoph Rader; Beatriz Gonzalez; Subhash C Sinha; Carlos F Barbas
Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector.
International journal of cancer. Journal international du cancer 2006;119(5):1194-207.
2006: Nina Jendreyko; Christoph Rader; C F Barbas; Gerhard Gaedicke
Simultaneous, phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody enhances antiangiogenic effects in vivo.
Klinische Pädiatrie 2006;218(3):143-51.
2005: Nina Jendreyko; Mikhail Popkov; Christoph Rader; Carlos F Barbas
Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8293-8.
2005: Mikhail Popkov; Nina Jendreyko; Dorian B McGavern; Christoph Rader; Carlos F Barbas
Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody.
Cancer research 2005;65(3):972-81.
2005: Karthik Venkatesh; Onanong Chivatakarn; Hakjoo Lee; Pushkar S Joshi; David B Kantor; Barbara A Newman; Rose G Mage; Christoph Rader; Roman J Giger
The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(4):808-22.
2004: Lian-Sheng Li; Christoph Rader; Masayuki Matsushita; Sanjib Das; Carlos F Barbas; Richard A Lerner; Subhash C Sinha
Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices.
Journal of medicinal chemistry 2004;47(23):5630-40.
2004: Subhash C Sinha; Lian-Sheng Li; Shin-Ichi Watanabe; Eiton Kaltgrad; Fujie Tanaka; Christoph Rader; Richard A Lerner; Carlos F Barbas
Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(21):5467-72.
2004: Mikhail Popkov; Christoph Rader; Carlos F Barbas
Isolation of human prostate cancer cell reactive antibodies using phage display technology.
Journal of immunological methods 2004;291(1-2):137-51.
2004: Mikhail Popkov; Nina Jendreyko; Gualberto Gonzalez-Sapienza; Rose G Mage; Christoph Rader; Carlos F Barbas
Human/mouse cross-reactive anti-VEGF receptor 2 recombinant antibodies selected from an immune b9 allotype rabbit antibody library.
Journal of immunological methods 2004;288(1-2):149-64.
2004: Anna Gopin; Christoph Rader; Doron Shabat
New chemical adaptor unit designed to release a drug from a tumor targeting device by enzymatic triggering.
Bioorganic & medicinal chemistry 2004;12(8):1853-8.
2004: Subhash C Sinha; Lian-Sheng Li; Gregory P Miller; Shantanu Dutta; Christoph Rader; Richard A Lerner
Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3095-9.
2004: Junho Chung; Christoph Rader; Mikhail Popkov; Young-Mi Hur; Hyun-Kyung Kim; Young-Joon Lee; Carlos F Barbas
Integrin alphaIIbbeta3-specific synthetic human monoclonal antibodies and HCDR3 peptides that potently inhibit platelet aggregation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):361-3.
2003: Nina Jendreyko; Mikhail Popkov; Roger R Beerli; Junho Chung; Dorian B McGavern; Christoph Rader; Carlos F Barbas
Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors.
The Journal of biological chemistry 2003;278(48):47812-9.
2003: Christoph Rader; James M Turner; Andreas Heine; Doron Shabat; Subhash C Sinha; Ian A Wilson; Richard A Lerner; Carlos F Barbas
A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy.
Journal of molecular biology 2003;332(4):889-99.
2003: Christoph Rader; Subhash C Sinha; Mikhail Popkov; Richard A Lerner; Carlos F Barbas
Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5396-400.
2003: Anna Gopin; Neta Pessah; Marina Shamis; Christoph Rader; Doron Shabat
A chemical adaptor system designed to link a tumor-targeting device with a prodrug and an enzymatic trigger.
Angewandte Chemie (International ed. in English) 2003;42(3):327-32.
2003: Mikhail Popkov; Rose G Mage; Cornelius B Alexander; Sujatha Thundivalappil; Carlos F Barbas; Christoph Rader
Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display.
Journal of molecular biology 2003;325(2):325-35.
2002: Christoph Rader; Mikhail Popkov; John A Neves; Carlos F Barbas
Integrin alpha(v)beta3 targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):2000-2.
2001: Doron Shabat; Holger N Lode; Ursula Pertl; Ralph A Reisfeld; Christoph Rader; Richard A Lerner; Carlos F Barbas
In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7528-33.
2000: P Steinberger; J K Sutton; Christoph Rader; M Elia; Carlos F Barbas
Generation and characterization of a recombinant human CCR5-specific antibody. A phage display approach for rabbit antibody humanization.
The Journal of biological chemistry 2000;275(46):36073-8.
2000: J Andris-Widhopf; Christoph Rader; P Steinberger; Roberta Fuller; Carlos F Barbas
Methods for the generation of chicken monoclonal antibody fragments by phage display.
Journal of immunological methods 2000;242(1-2):159-81.
2000: Christoph Rader; Benjamin List
Catalytic antibodies as magic bullets.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(12):2091-5.
2000: Christoph Rader; G Ritter; S Nathan; M Elia; Ivan T Gout; Achim A Jungbluth; L S Cohen; Sydney Welt; Lloyd J Old; Carlos F Barbas
The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies.
The Journal of biological chemistry 2000;275(18):13668-76.
2000: A Karlstrom; Guofu Zhong; Christoph Rader; Nicholas A Larsen; Andreas Heine; Roberta Fuller; Benjamin List; Fujie Tanaka; Ian A Wilson; Carlos F Barbas; Richard A Lerner
Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3878-83.
1999: Doron Shabat; Christoph Rader; Benjamin List; Richard A Lerner; Carlos F Barbas
Multiple event activation of a generic prodrug trigger by antibody catalysis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6925-30.
1998: Christoph Rader; David A Cheresh; Carlos F Barbas
A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8910-5.
1997: Christoph Rader; Carlos F Barbas
Phage display of combinatorial antibody libraries.
Current opinion in biotechnology 1997;8(4):503-8.