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Daniel Rader

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Marina Cuchel; Daniel J Rader
Microsomal transfer protein inhibition in humans.
Stephen R Master; Daniel J Rader
Beyond LDL Cholesterol in Assessing Cardiovascular Risk: apo B or LDL-P?
Hui Li; Eric T Alexander; Padmaja Dhanasekaran; Michael C Phillips; Daniel J Rader; Sissel Lund-Katz
Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels.

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All Publications

2013: Marina Cuchel; Daniel J Rader
Microsomal transfer protein inhibition in humans.
Current opinion in lipidology 2013;24(3):246-50.
2013: Stephen R Master; Daniel J Rader
Beyond LDL Cholesterol in Assessing Cardiovascular Risk: apo B or LDL-P?
Clinical chemistry 2013;59(5):723-5.
2013: Hui Li; Eric T Alexander; Padmaja Dhanasekaran; Michael C Phillips; Daniel J Rader; Sissel Lund-Katz
Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(4):687-93.
2013: Devashish Kothapalli; Sissel Lund-Katz; Michael C Phillips; Daniel J Rader; Paola Castagnino; Richard K Assoian
Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2-dependent repression of miR221/222.
Atherosclerosis 2013;227(1):65-71.
2013: Marina Cuchel; Anna M E Du Plessis; Hendrik du Toit Theron; Daniel Gaudet; Robert A Hegele; A David Marais; Emma A Meagher; Kathleen J Propert; Daniel J Rader; Bill Sasiela; Prediman K Shah; Cesare R Sirtori; Claudia Stefanutti; Giovanni B Vigna; Maurizio R Averna; LeAnne T Bloedon; Dirk J Blom
Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study.
Lancet 2013;381(9860):40-6.
2013: Anandita Agarwala; Jeffrey Billheimer; Daniel J Rader
Mighty minipig in fight against cardiovascular disease.
Science translational medicine 2013;5(166):166fs1.
2013: Subhasish Bose; Seth Braunstein; Nayyar Iqbal; Parasuram Krishnamoorthy; Stephen R Master; Jayamohan Nair; Daniel J Rader; Muredach P Reilly; Mark H Schutta; Stanley Schwartz; Ajay Varanasi; Caitlin St Clair; Nehal N Mehta
Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines.
Obesity (Silver Spring, Md.) 2013;21(1):E118-23.
2013: Sadik H Kassim; William Lagor; Hui Li; Peter Bell; Jeffrey Billheimer; Frank Jacobs; Suryanarayan Somanathan; James M Wilson; Daniel J Rader
Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia.
Human gene therapy 2013;24(1):19-26.
2012: Arman Qamar; Daniel J Rader
Effect of interleukin 1β inhibition in cardiovascular disease.
Current opinion in lipidology 2012;23(6):548-53.
2012: Daniel B Larach; Emil M deGoma; Daniel J Rader
Targeting high density lipoproteins in the prevention of cardiovascular disease?
Current cardiology reports 2012;14(6):684-91.
2012: Devashish Kothapalli; Shu-Lin Liu; Sissel Lund-Katz; James Monslow; Michael C Phillips; Ellen Puré; Daniel J Rader; Shilpa Rao; Tina Xu; Yong Ho Bae; Fitzroy J Byfield; Paola Castagnino; Elizabeth A Hawthorne; Paul A Janmey; Richard K Assoian
Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening.
Cell reports 2012;2(5):1259-71.
2012: Sheela N Magge; Emile R Mohler; Divya Prasad; Paul R Gallagher; Dorit Koren; Lorraine E Levitt Katz; Nicolas Stettler; Daniel J Rader
Prediabetic obese adolescents have a more atherogenic lipoprotein profile compared with normoglycemic obese peers.
The Journal of pediatrics 2012;161(5):881-6.
2012: Daniel J Rader; Emil M deGoma
Approach to the patient with extremely low HDL-cholesterol.
The Journal of clinical endocrinology and metabolism 2012;97(10):3399-407.
2012: M Haris U Usman; Ramprasad Gadi; Harsh Goel; Jaison Hampson; Scott Lilly; Megan L Mucksavage; Grace A Nathanson; Arman Qamar; Daniel J Rader; Richard L Dunbar
Extended-release niacin acutely suppresses postprandial triglyceridemia.
The American journal of medicine 2012;125(10):1026-35.
2012: Daniel J Rader; Alan R Tall
The not-so-simple HDL story: Is it time to revise the HDL cholesterol hypothesis?
Nature medicine 2012;18(9):1344-6.
2012: Nehal N Mehta; Daniel J Rader; Anna Raper; Muredach P Reilly; Amrith Rodrigues; Abby VanVoorhees; Mackenzie Wilcox; Megan Wolfe; YiDing Yu; Amanda Baer; Stephanie DerOhannesian; William Farver; Parasuram Krishnamoorthy; Ron Li; Joel M Gelfand
Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis.
Atherosclerosis 2012;224(1):218-21.
2012: Emil M deGoma; Daniel J Rader
High-density lipoprotein particle number: a better measure to quantify high-density lipoprotein?
Journal of the American College of Cardiology 2012;60(6):517-20.
2012: Sheng-Yu Jin; Daniel J Rader; Junichiro Tohyama; Robert C Bauer; Na Nora Cao; X Long Zheng
Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(8):1817-23.
2012: Jing He; Hongzhe Li; Andrew C Edmondson; Daniel J Rader; Mingyao Li
A Gaussian copula approach for the analysis of secondary phenotypes in case-control genetic association studies.
Biostatistics (Oxford, England) 2012;13(3):497-508.
2012: Alanna Strong; Daniel J Rader
Sortilin as a regulator of lipoprotein metabolism.
Current atherosclerosis reports 2012;14(3):211-8.
2012: Margaret R Diffenderfer; Gregory G Dolnikowski; John S Millar; Chorthip Nartsupha; Daniel J Rader; P Hugh R Barrett; Margaret E Brousseau; Peter M Schaefer; Megan L Wolfe; Ernst J Schaefer
Effects of CETP inhibition on triglyceride-rich lipoprotein composition and apoB-48 metabolism.
Journal of lipid research 2012;53(6):1190-9.
2012: Wijtske Annema; Arne Dikkers; Jan Freark de Boer; Thomas Gautier; Daniel J Rader; Patrick C N Rensen; Uwe J F Tietge
ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma.
Journal of lipid research 2012;53(5):929-40.
2012: Emil M deGoma; Joshua W Knowles; Fabio Angeli; Matthew J Budoff; Daniel J Rader
The evolution and refinement of traditional risk factors for cardiovascular disease.
Cardiology in review 2012;20(3):118-29.
2012: Daniel J Rader; Michael S Parmacek
Secreted miRNAs suppress atherogenesis.
Nature cell biology 2012;14(3):233-5.
2012: Jane Francisca Ferguson; Hakon Hakonarson; Christine C Hinkle; Mingyao Li; Stephen R Master; Nehal N Mehta; Megan I Mucksavage; Daniel J Rader; Roshanak Bagheri; Jonathan P Bradfield; Stephanie L Derohannessian; Rhia Shah; Xuexia Wang; Muredach P Reilly
Translational studies of lipoprotein-associated phospholipase A₂ in inflammation and atherosclerosis.
Journal of the American College of Cardiology 2012;59(8):764-72.
2012: Daniel P O'Connell; Daniel J Rader; Jeffrey Billheimer; Debra Cromley; Daniel F LeBlanc; William W Bachovchin
Design and synthesis of boronic acid inhibitors of endothelial lipase.
Bioorganic & medicinal chemistry letters 2012;22(3):1397-401.
2012: Ioannis M Stylianou; Muredach P Reilly; Robert C Bauer; Daniel J Rader
Genetic basis of atherosclerosis: insights from mice and humans.
Circulation research 2012;110(2):337-55.
2012: William R Lagor; Wen Lin; George H Rothblat; Nathaniel Weintraub; Kaijin Wu; Margarita de la Llera-Moya; Denise Drazul-Schrader; David W Fields; Sarah F Hamm-Alvarez; Sumeet A Khetarpal; Arthi Kumaravel; Daniel J Rader
The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.
PloS one 2012;7(2):e31616.
2011: Ginny L Weibel; Aisha Wilson; Jeffrey Billheimer; Sara Hayes; Michael C Phillips; Daniel J Rader; George H Rothblat
Novel in vivo method for measuring cholesterol mass flux in peripheral macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(12):2865-71.
2011: Parin J Patel; Kashif Jafri; Amit V Khera; Robert L Wilensky; Daniel J Rader
The anti-oxidative capacity of high-density lipoprotein is reduced in acute coronary syndrome but not in stable coronary artery disease.
Journal of the American College of Cardiology 2011;58(20):2068-75.
2011: Fiona C McGillicuddy; Muredach P Reilly; Daniel J Rader
Adipose modulation of high-density lipoprotein cholesterol: implications for obesity, high-density lipoprotein metabolism, and cardiovascular disease.
Circulation 2011;124(15):1602-5.
2011: Shigenori Yamamoto; Hiroyuki Tanigawa; Jeffrey T Billheimer; Yohei Komaru; Xiaoyu Li; Daniel J Rader
Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport.
Circulation 2011;124(12):1382-90.
2011: Sadik H Kassim; Luk Vandenberghe; James M Wilson; Ruben Hovhannisyan; Daniel J Rader
Identification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaques.
Physiological genomics 2011;43(15):911-6.
2011: Nehal N Mehta; Daniel J Rader
Fluorescent green plaques: light at the end of the catheter?
Cell metabolism 2011;14(1):7-8.
2011: Kazuhiro Nakaya; Junichiro Tohyama; Snehal U Naik; Hiroyuki Tanigawa; Colin H Macphee; Jeffrey T Billheimer; Daniel J Rader
Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(6):1276-82.
2011: Sheela N Magge; Nicolas Stettler; Dorit Koren; Lorraine E Levitt Katz; Paul R Gallagher; Emile R Mohler; Daniel J Rader
Adiponectin is associated with favorable lipoprotein profile, independent of BMI and insulin resistance, in adolescents.
The Journal of clinical endocrinology and metabolism 2011;96(5):1549-54.
2011: Emil M deGoma; Daniel J Rader
Novel HDL-directed pharmacotherapeutic strategies.
Nature reviews. Cardiology 2011;8(5):266-77.
2011: Nehal N Mehta; Mingyao Li; Dilusha William; Amit V Khera; Stephanie DerOhannessian; Liming Qu; Jane Francisca Ferguson; Catherine McLaughlin; Lalarukh Haris Shaikh; Rhia Shah; Parth N Patel; Jonathan P Bradfield; Jing He; Ioannis M Stylianou; Hakon Hakonarson; Daniel J Rader; Muredach P Reilly
The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels.
European heart journal 2011;32(8):963-71.
2011: Robert C Bauer; Ioannis M Stylianou; Daniel J Rader
Functional validation of new pathways in lipoprotein metabolism identified by human genetics.
Current opinion in lipidology 2011;22(2):123-8.
2011: Andrew C Edmondson; Peter S Braund; Ioannis M Stylianou; Amit V Khera; Christopher P Nelson; Megan L Wolfe; Stephanie L Derohannessian; Brendan J Keating; Liming Qu; Jing He; Martin D Tobin; Maciej Tomaszewski; Jens Baumert; Norman Klopp; Angela Döring; Barbara Thorand; Mingyao Li; Muredach P Reilly; Wolfgang Koenig; Nilesh J Samani; Daniel J Rader
Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol.
Circulation. Cardiovascular genetics 2011;4(2):145-55.
2011: Niels Nijstad; Jan Freark de Boer; William R Lagor; Markus Toelle; David Usher; Wijtske Annema; Markus van der Giet; Daniel J Rader; Uwe J F Tietge
Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice.
Biochimica et biophysica acta 2011;1811(4):294-9.
2011: Sue-Anne Toh; John S Millar; Jeffrey T Billheimer; Ilia V Fuki; Snehal U Naik; Colin H Macphee; Max Walker; Daniel J Rader
PPARγ activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI.
Biochemical pharmacology 2011;81(7):934-41.
2011: Niels Nijstad; Thomas Gautier; François Briand; Daniel J Rader; Uwe J F Tietge
Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice.
Gastroenterology 2011;140(3):1043-51.
2011: Nehal N Mehta; Parasuram Krishnamoorthy; Seth S Martin; Caitlin St Clair; Stanley Schwartz; Nayyar Iqbal; Seth Braunstein; Mark H Schutta; Daniel J Rader; Muredach P Reilly
Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus.
The American journal of cardiology 2011;107(3):406-11.
2011: Eric T Alexander; Charulatha Vedhachalam; Sandhya Sankaranarayanan; Margarita de la Llera-Moya; George H Rothblat; Daniel J Rader; Michael C Phillips
Influence of apolipoprotein A-I domain structure on macrophage reverse cholesterol transport in mice.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(2):320-7.
2011: Jing He; Kai Wang; Andrew C Edmondson; Daniel J Rader; Chun Li; Mingyao Li
Gene-based interaction analysis by incorporating external linkage disequilibrium information.
European journal of human genetics : EJHG 2011;19(2):164-72.
2011: Amit V Khera; Marina Cuchel; Margarita de la Llera-Moya; Amrith Rodrigues; Megan F Burke; Kashif Jafri; Benjamin C French; Julie A Phillips; Megan L Mucksavage; Robert L Wilensky; Emile R Mohler; George H Rothblat; Daniel J Rader
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.
The New England journal of medicine 2011;364(2):127-35.
2011: Kai Wang; Dawn M Waterworth; Muredach P Reilly; Mary Susan Burnett; Joseph M Devaney; Andrew C Edmondson; Stephen E Epstein; Fan Gao; Struan F A Grant; Hakon Hakonarson; Mingyao Li; Vincent Mooser; Atif N Qasim; Daniel J Rader
Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation.
Frontiers in genetics 2011;2():41.
2011: Raymond R Townsend; Jackson T Wright; Amanda H Anderson; Jing Chen; Harold I Feldman; Jeffrey C Fink; Crystal A Gadebegku; Alan S Go; Marshall Joffe; Lisa A Nessel; Akinlolu O Ojo; Daniel J Rader; Muredach P Reilly; Valerie Teal; Karen Teff; Dawei Xie
Metabolic syndrome, components, and cardiovascular disease prevalence in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.
American journal of nephrology 2011;33(6):477-84.
2011: William R Lagor; Daniel J Rader
Phospholipidation of HDL--how much is too much?
Clinical chemistry 2011;57(1):4-6.
2011: John S Millar; Katsunori Ikewaki; LeAnne T Bloedon; Megan L Wolfe; Philippe Szapary; Daniel J Rader
Effect of rosiglitazone on HDL metabolism in subjects with metabolic syndrome and low HDL.
Journal of lipid research 2011;52(1):136-42.
2011: Atif N Qasim; Venkata Budharaju; Nehal N Mehta; Caitlin St Clair; Samira Farouk; Seth Braunstein; Mark H Schutta; Nayyar Iqbal; Daniel J Rader; Muredach P Reilly
Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes.
Clinical endocrinology 2011;74(1):44-50.
2010: Ralph Burkhardt; Sue-Anne Toh; William R Lagor; Andrew Birkeland; Michael Levin; Xiaoyu Li; Megan Robblee; Victor D Fedorov; Masahiro Yamamoto; Takashi Satoh; Shizuo Akira; Sekar Kathiresan; Jan L Breslow; Daniel J Rader
Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice.
The Journal of clinical investigation 2010;120(12):4410-4.
2010: Tomoyuki Yasuda; Tatsuro Ishida; Daniel J Rader
Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(11):2263-70.
2010: Xiaoyu Li; John S Millar; Nicholas Brownell; Francois BRIAND; Daniel J Rader
Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.
Biochemical pharmacology 2010;80(9):1450-7.
2010: Fumin Tong; Jeffrey Billheimer; Caryn F Shechtman; Ying Liu; Rosanne M Crooke; Mark Graham; David E Cohen; Stephen L Sturley; Daniel J Rader
Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism.
The Journal of biological chemistry 2010;285(44):33632-41.
2010: Jun Liu; Huq Afroza; Daniel J Rader; Weijun Jin
Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases.
The Journal of biological chemistry 2010;285(36):27561-70.
2010: Amit V Khera; Megan L Wolfe; Christopher P Cannon; Jie Qin; Daniel J Rader
On-statin cholesteryl ester transfer protein mass and risk of recurrent coronary events (from the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 [PROVE IT-TIMI 22] study).
The American journal of cardiology 2010;106(4):451-6.
2010: Robert J Brown; William R Lagor; Sandhya Sankaranaravanan; Tomoyuki Yasuda; Thomas Quertermous; George H Rothblat; Daniel J Rader
Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins.
Circulation research 2010;107(3):357-64.
2010: Samira S Farouk; Daniel J Rader; Muredach P Reilly; Nehal N Mehta
CXCL12: a new player in coronary disease identified through human genetics.
Trends in cardiovascular medicine 2010;20(6):204-9.
2010: John S Millar; Bonnie Ky; Megan L Wolfe; Leticia Pruscino; Amanda Baer; Daniel J Rader
Short-term treatment with high-dose atorvastatin reduces LDL cholesterol but shows no anti-inflammatory effects in normolipidemic subjects with normal CRP levels.
Clinical and translational science 2010;3(4):140-6.
2010: Sebastian Zeissig; Stephanie K Dougan; Duarte C Barral; Yvonne Junker; Zhangguo Chen; Arthur Kaser; Madelyn Ho; Hannah Mandel; Adam McIntyre; Susan M Kennedy; Gavin F Painter; Natacha Veerapen; Gurdyal S Besra; Vincenzo Cerundolo; Simon Yue; Sarah Beladi; Samuel M Behar; Xiuxu Chen; Jenny E Gumperz; Karine Breckpot; Anna Raper; Amanda Baer; Mark A Exley; Robert A Hegele; Marina Cuchel; Daniel J Rader; Nicholas O Davidson; Richard S Blumberg
Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.
The Journal of clinical investigation 2010;120(8):2889-99.
2010: Megan F Burke; Richard L Dunbar; Daniel J Rader
Could exercise metabolomics pave the way for gymnomimetics?
Science translational medicine 2010;2(41):41ps35.
2010: Prabhjot S Nijjar; Frances M Burke; Annette Bloesch; Daniel J Rader
Role of dietary supplements in lowering low-density lipoprotein cholesterol: a review.
Journal of clinical lipidology 2010;4(4):248-58.
2010: Joseph T Glessner; Muredach P Reilly; Cecilia E Kim; Nagahide Takahashi; Anthony Albano; Cuiping Hou; Jonathan P Bradfield; Haitao Zhang; Patrick M A Sleiman; James H Flory; Marcin Imielinski; Edward C Frackelton; Rosetta M Chiavacci; Kelly A Thomas; Maria Garris; Frederick G Otieno; Michael Davidson; Mark Weiser; Abraham Reichenberg; Kenneth L Davis; Joseph I Friedman; Thomas P Cappola; Kenneth B Margulies; Daniel J Rader; Struan F A Grant; Joseph Buxbaum; Raquel E Gur; Hakon Hakonarson
Strong synaptic transmission impact by copy number variations in schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(23):10584-9.
2010: Ashish S Shah; Daniel J Rader; John S Millar
The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans.
Atherosclerosis 2010;210(1):35-40.
2010: Tomoyuki Yasuda; Didier Grillot; Jeffery T Billheimer; Francois BRIAND; Philippe Delerive; Stephane Huet; Daniel J Rader
Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(4):781-6.
2010: Margarita de la Llera-Moya; Denise Drazul-Schrader; Bela F Asztalos; Marina Cuchel; Daniel J Rader; George H Rothblat
The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(4):796-801.
2010: Mingyao Li; Muredach P Reilly; Daniel J Rader; Li-San Wang
Correcting population stratification in genetic association studies using a phylogenetic approach.
Bioinformatics (Oxford, England) 2010;26(6):798-806.
2010: Megan F Burke; Amit V Khera; Daniel J Rader
Polyphenols and cholesterol efflux: is coffee the next red wine?
Circulation research 2010;106(4):627-9.
2010: Marina Cuchel; Sissel Lund-Katz; Margarita de la Llera-Moya; John S Millar; David Chang; Ilia V Fuki; George H Rothblat; Michael C Phillips; Daniel J Rader
Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(3):526-32.
2010: Steven C Halbert; Benjamin French; Ram Y Gordon; John T Farrar; Kathryn Schmitz; Patti B Morris; Paul D Thompson; Daniel J Rader; David J Becker
Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance.
The American journal of cardiology 2010;105(2):198-204.
2010: sadik kassim; Hui Li; Luk Vandenberghe; Christian Hinderer; Peter Bell; Dawn Marchadier; Aisha Wilson; Debra Cromley; Valeska Redon; Hongwei Yu; James M Wilson; Daniel J Rader
Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis.
PloS one 2010;5(10):e13424.
2010: Amit V Khera; Daniel J Rader
Future therapeutic directions in reverse cholesterol transport.
Current atherosclerosis reports 2010;12(1):73-81.
2009: Sean P Heffron; Ioannis Parastatidis; Marina Cuchel; Megan L Wolfe; Mahlet G Tadesse; Emille R Mohler; Harry Ischiropoulos; Daniel J Rader; Muredach P Reilly
Inflammation induces fibrinogen nitration in experimental human endotoxemia.
Free radical biology & medicine 2009;47(8):1140-6.
2009: Eric T Alexander; Ginny L Weibel; Michelle R Joshi; Charulatha Vedhachalam; Margarita de la Llera-Moya; George H Rothblat; Michael C Phillips; Daniel J Rader
Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(10):1496-501.
2009: Tomoyuki Nishimoto; Michael Pellizzon; Masakazu Aihara; Ioannis M Stylianou; Jeffery T Billheimer; George H Rothblat; Daniel J Rader
Fish oil promotes macrophage reverse cholesterol transport in mice.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(10):1502-8.
2009: Robert J Brown; Andrew C Edmondson; Nathalie Griffon; Theophelus B Hill; Ilia V Fuki; Karen O Badellino; Mingyao Li; Megan L Wolfe; Muredach P Reilly; Daniel J Rader
A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis.
Journal of lipid research 2009;50(9):1910-6.
2009: Amit V Khera; Daniel J Rader
Discovery and validation of new molecular targets in treating dyslipidemia: the role of human genetics.
Trends in cardiovascular medicine 2009;19(6):195-201.
2009: Hiroyuki Tanigawa; Jeffrey T Billheimer; Jun-ichiro Tohyama; Ilia V Fuki; Dominic S Ng; George H Rothblat; Daniel J Rader
Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo.
Circulation 2009;120(2):160-9.
2009: Peter Kanetsky; Nandita Mitra; Saran Vardhanabhuti; Mingyao Li; David J Vaughn; Richard Letrero; Stephanie L Ciosek; David R Doody; Lauren M Smith; Joellen Weaver; Anthony Albano; Chu Chen; Jacqueline R Starr; Daniel J Rader; Andrew K Godwin; Muredach P Reilly; Hakon Hakonarson; Stephen M Schwartz; Katherine L Nathanson
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.
Nature genetics 2009;41(7):811-5.
2009: Eric T Alexander; Masafumi Tanaka; Momoe Kono; Hiroyuki Saito; Daniel J Rader; Michael C Phillips
Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I.
Journal of lipid research 2009;50(7):1409-19.
2009: Margaret E Brousseau; John S Millar; Margaret R Diffenderfer; Chorthip Nartsupha; Bela F Asztalos; Megan L Wolfe; James P Mancuso; Andres G Digenio; Daniel J Rader; Ernst J Schaefer
Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apolipoprotein A-II metabolism.
Journal of lipid research 2009;50(7):1456-62.
2009: David J Becker; Ram Y Gordon; Steven C Halbert; Benjamin French; Patti B Morris; Daniel J Rader
Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial.
Annals of internal medicine 2009;150(12):830-9, W147-9.
2009: Junichiro Tohyama; Jeffrey T Billheimer; Ilia V Fuki; George H Rothblat; Daniel J Rader; John S Millar
Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice.
Atherosclerosis 2009;204(2):418-23.
2009: Guipeng An; Takashi Miwa; Wen-Liang Song; John A Lawson; Daniel J Rader; Yun Zhang; Wen-Chao Song
CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice.
Molecular immunology 2009;46(8-9):1702-9.
2009: Atif N Qasim; Thomas S Metkus; Mahlet G Tadesse; Michael Lehrke; Stephanie Restine; Megan L Wolfe; Sridhar Hannenhalli; Thomas Cappola; Daniel J Rader; Muredach P Reilly
Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians.
Clinical endocrinology 2009;70(5):698-705.
2009: Francois BRIAND; Snehal U Naik; Ilia Fuki; John S Millar; Colin H Macphee; Max Walker; Jeffrey Billheimer; George Rothblat; Daniel J Rader
Both the peroxisome proliferator-activated receptor delta agonist, GW0742, and ezetimibe promote reverse cholesterol transport in mice by reducing intestinal reabsorption of HDL-derived cholesterol.
Clinical and translational science 2009;2(2):127-33.
2009: Daniel J Rader; Eric T Alexander; Ginny L Weibel; Jeffrey T Billheimer; George H Rothblat
The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis.
Journal of lipid research 2009;50 Suppl():S189-94.
2009: Hemanth Neeli; Ram Gadi; Daniel J Rader
Managing diabetic dyslipidemia: beyond statin therapy.
Current diabetes reports 2009;9(1):11-7.
2009: Ram Y Gordon; David J Becker; Daniel J Rader
Reduced efficacy of rosuvastatin by St. John's Wort.
The American journal of medicine 2009;122(2):e1-2.
2009: Ioannis M Stylianou; Karen L Svenson; Sara K VanOrman; Yanina Langle; John S Millar; Beverly Paigen; Daniel J Rader
Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein.
PloS one 2009;4(8):e6521.
2009: Wengen Chen; Gonca Bural; Drew A Torigian; Daniel J Rader; Abass Alavi
Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries.
European journal of nuclear medicine and molecular imaging 2009;36(1):144-51.
2008: Daniel M Kolansky; Marina Cuchel; Bernard J Clark; Stephen M Paridon; Brian W McCrindle; Susan E Wiegers; Luis Araujo; Yogesh Vohra; Joep C Defesche; James M Wilson; Daniel J Rader
Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia.
The American journal of cardiology 2008;102(11):1438-43.
2008: Sue-Anne Toh; Daniel J Rader
Dyslipidemia in insulin resistance: clinical challenges and adipocentric therapeutic frontiers.
Expert review of cardiovascular therapy 2008;6(7):1007-22.
2008: Frederick F Samaha; James McKenney; LeAnne T Bloedon; Bill Sasiela; Daniel J Rader
Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia.
Nature clinical practice. Cardiovascular medicine 2008;5(8):497-505.
2008: LeAnne T Bloedon; Richard Dunbar; Danielle Duffy; Paula Pinell-Salles; Robert Norris; Bruce J DeGroot; Rajesh Movva; Mohamad Navab; Alan M Fogelman; Daniel J Rader
Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients.
Journal of lipid research 2008;49(6):1344-52.
2008: Rajesh Movva; Daniel J Rader
Laboratory assessment of HDL heterogeneity and function.
Clinical chemistry 2008;54(5):788-800.
2008: Bonnie Ky; Anne Burke; Sotirios Tsimikas; Megan L Wolfe; Mahlet G Tadesse; Philippe Szapary; Joseph L Witztum; garret fitzgerald; Daniel J Rader
The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans.
Journal of the American College of Cardiology 2008;51(17):1653-62.
2008: Miao Wang; Eric Lee; Wenliang Song; Emanuela Ricciotti; Daniel J Rader; John A Lawson; Ellen Puré; garret fitzgerald
Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation.
Circulation 2008;117(10):1302-9.
2008: Ying Liu; John S Millar; Debra Cromley; Mark Graham; Rosanne Crooke; Jeffrey T Billheimer; Daniel J Rader
Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice.
Biochimica et biophysica acta 2008;1781(3):97-104.
2008: John S Millar; Margaret E Brousseau; Margaret R Diffenderfer; Hugh Barrett; Francine K Welty; Jeffrey S Cohn; Aisha Wilson; Megan L Wolfe; Chorthip Nartsupha; Peter M Schaefer; Andres G Digenio; James P Mancuso; Gregory G Dolnikowski; Ernst Schaefer; Daniel J Rader
Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on VLDL apolipoprotein E metabolism.
Journal of lipid research 2008;49(3):543-9.
2008: Daniel J Rader; Alan Daugherty
Translating molecular discoveries into new therapies for atherosclerosis.
Nature 2008;451(7181):904-13.
2008: Karen O Badellino; Megan L Wolfe; Muredach P Reilly; Daniel J Rader
Endothelial lipase is increased in vivo by inflammation in humans.
Circulation 2008;117(5):678-85.
2008: LeAnne T Bloedon; Shilpa Balikai; Jesse Chittams; Stephen C Cunnane; Jesse A Berlin; Daniel J Rader; Philippe Szapary
Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial.
Journal of the American College of Nutrition 2008;27(1):65-74.
2008: Sylvia E Rosas; Marshall Joffe; Megan Wolfe; Kenneth L Brayman; Daniel J Rader
Effects of renal replacement therapy on plasma lipoprotein(a) levels.
American journal of nephrology 2008;28(3):361-5.
2008: Helene Glassberg; Daniel J Rader
Management of lipids in the prevention of cardiovascular events.
Annual review of medicine 2008;59():79-94.
2008: Kamilah Ali; Sissel Lund-Katz; John Lawson; Michael C Phillips; Daniel J Rader
Structure-function properties of the apoE-dependent COX-2 pathway in vascular smooth muscle cells.
Atherosclerosis 2008;196(1):201-9.
2007: Daniel J Rader
Liver X receptor and farnesoid X receptor as therapeutic targets.
The American journal of cardiology 2007;100(11 A):n15-9.
2007: Robert J Brown; Daniel J Rader
Lipases as modulators of atherosclerosis in murine models.
Current drug targets 2007;8(12):1307-19.
2007: Scott M Lilly; Daniel J Rader
New targets and emerging therapies for reducing LDL cholesterol.
Current opinion in lipidology 2007;18(6):650-5.
2007: Marina Cuchel; Daniel J Rader
Is the cholesteryl ester transfer protein proatherogenic or antiatherogenic in humans?
Journal of the American College of Cardiology 2007;50(20):1956-8.
2007: Bruce S Sachais; Tiffany Turrentine; Jennine M Dawicki McKenna; Ann H Rux; Daniel J Rader; M Anna Kowalska
Elimination of platelet factor 4 (PF4) from platelets reduces atherosclerosis in C57Bl/6 and apoE-/- mice.
Thrombosis and haemostasis 2007;98(5):1108-13.
2007: Maria Pia Adorni; Francesca Zimetti; Jeffrey T Billheimer; Nan Wang; Daniel J Rader; Michael C Phillips; George H Rothblat
The roles of different pathways in the release of cholesterol from macrophages.
Journal of lipid research 2007;48(11):2453-62.
2007: Hiroyuki Tanigawa; Jeffrey T Billheimer; Jun-ichiro Tohyama; YuZhen Zhang; George H Rothblat; Daniel J Rader
Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport.
Circulation 2007;116(11):1267-73.
2007: K Schankel; J Robinson; Roy D Bloom; C Guerra; Daniel J Rader; Marshall Joffe; Sylvia E Rosas
Determinants of coronary artery calcification progression in renal transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(9):2158-64.
2007: Ginny L Weibel; Eric T Alexander; Michelle R Joshi; Daniel J Rader; Sissel Lund-Katz; Michael C Phillips; George H Rothblat
Wild-type ApoA-I and the Milano variant have similar abilities to stimulate cellular lipid mobilization and efflux.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(9):2022-9.
2007: Danielle Skropeta; Chatri Settasatian; Monica R McMahon; Kate Shearston; Daniela Caiazza; Kristine C McGrath; Weijun Jin; Daniel J Rader; Philip J Barter; Kerry-Anne Rye
N-Glycosylation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins.
Journal of lipid research 2007;48(9):2047-57.
2007: Weijun Jin; Xun Wang; John S Millar; Thomas Quertermous; George H Rothblat; Jane M Glick; Daniel J Rader
Hepatic proprotein convertases modulate HDL metabolism.
Cell metabolism 2007;6(2):129-36.
2007: Xun Wang; Heidi L Collins; Mollie Ranalletta; Ilia V Fuki; Jeffrey T Billheimer; George H Rothblat; Alan R Tall; Daniel J Rader
Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo.
The Journal of clinical investigation 2007;117(8):2216-24.
2007: Xun Wang; Daniel J Rader
Molecular regulation of macrophage reverse cholesterol transport.
Current opinion in cardiology 2007;22(4):368-72.
2007: Vaneeta Bamba; Daniel J Rader
Obesity and atherogenic dyslipidemia.
Gastroenterology 2007;132(6):2181-90.
2007: Robert J Brown; Gwen C Miller; Nathalie Griffon; Christopher J Long; Daniel J Rader
Glycosylation of endothelial lipase at asparagine-116 reduces activity and the hydrolysis of native lipoproteins in vitro and in vivo.
Journal of lipid research 2007;48(5):1132-9.
2007: Xun Wang; Weijun Jin; Daniel J Rader
Upregulation of macrophage endothelial lipase by toll-like receptors 4 and 3 modulates macrophage interleukin-10 and -12 production.
Circulation research 2007;100(7):1008-15.
2007: Daniel J Rader
Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus.
The American journal of medicine 2007;120(3 Suppl 1):S12-8.
2007: Michael Pellizzon; Jeffrey T Billheimer; LeAnne T Bloedon; Philippe Szapary; Daniel J Rader
Flaxseed reduces plasma cholesterol levels in hypercholesterolemic mouse models.
Journal of the American College of Nutrition 2007;26(1):66-75.
2007: Daniel J Rader
Mechanisms of disease: HDL metabolism as a target for novel therapies.
Nature clinical practice. Cardiovascular medicine 2007;4(2):102-9.
2007: Michael Lehrke; Segan C Millington; Martina Lefterova; Reshmaal Gomes Cumaranatunge; Philippe Szapary; Robert L Wilensky; Daniel J Rader; Mitchell Lazar; Muredach P Reilly
CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans.
Journal of the American College of Cardiology 2007;49(4):442-9.
2007: Marina Cuchel; LeAnne T Bloedon; Philippe Szapary; Daniel M Kolansky; Megan L Wolfe; Antoine Sarkis; John S Millar; Katsunori Ikewaki; Evan S Siegelman; Richard E Gregg; Daniel J Rader
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia.
The New England journal of medicine 2007;356(2):148-56.
2007: Corinna Lebherz; Julio Sanmiguel; James M Wilson; Daniel J Rader
Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent.
Cardiovascular diabetology 2007;6():15.
2007: Muredach P Reilly; Anand Rohatgi; Kimberly McMahon; Megan L Wolfe; Shailesh C Pinto; Thomas Rhodes; Cynthia Girman; Daniel J Rader
Plasma cytokines, metabolic syndrome, and atherosclerosis in humans.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2007;55(1):26-35.
2006: Daniel J Rader
Molecular regulation of HDL metabolism and function: implications for novel therapies.
The Journal of clinical investigation 2006;116(12):3090-100.
2006: Uli C Broedl; Weijun Jin; Ilia V Fuki; John S Millar; Daniel J Rader
Endothelial lipase is less effective at influencing HDL metabolism in vivo in mice expressing apoA-II.
Journal of lipid research 2006;47(10):2191-7.
2006: John S Millar; Scot J Stone; Uwe J F Tietge; Bryan Tow; Jeffrey T Billheimer; Jinny S Wong; Robert L Hamilton; Robert V Farese; Daniel J Rader
Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production.
Journal of lipid research 2006;47(10):2297-305.
2006: Ken Kitajima; Dawn Marchadier; Gwen C Miller; Guang-Ping Gao; James M Wilson; Daniel J Rader
Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1852-7.
2006: Nathalie Griffon; Elaine C Budreck; Christopher J Long; Uli C Broedl; Dawn Marchadier; Jane M Glick; Daniel J Rader
Substrate specificity of lipoprotein lipase and endothelial lipase: studies of lid chimeras.
Journal of lipid research 2006;47(8):1803-11.
2006: Muredach Reilly; Daniel J Rader
Apolipoprotein E and coronary disease: a puzzling paradox.
PLoS medicine 2006;3(6):e258.
2006: John S Millar; Margaret E Brousseau; Margaret R Diffenderfer; Hugh Barrett; Francine K Welty; Aisha Faruqi; Megan L Wolfe; Chorthip Nartsupha; Andres G Digenio; James P Mancuso; Gregory G Dolnikowski; Ernst Schaefer; Daniel J Rader
Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism in humans.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(6):1350-6.
2006: Marina Cuchel; Daniel J Rader
Macrophage reverse cholesterol transport: key to the regression of atherosclerosis?
Circulation 2006;113(21):2548-55.
2006: Atif Qasim; Daniel J Rader
Human genetics of variation in high-density lipoprotein cholesterol.
Current atherosclerosis reports 2006;8(3):198-205.
2006: Ken Kitajima; Dawn Marchadier; Haim Burstein; Daniel J Rader
Persistent liver expression of murine apoA-l using vectors based on adeno-associated viral vectors serotypes 5 and 1.
Atherosclerosis 2006;186(1):65-73.
2006: Frederick F Samaha; Philippe Szapary; Nayyar Iqbal; Monica M Williams; LeAnne T Bloedon; Arshneel Kochar; Megan L Wolfe; Daniel J Rader
Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(3):624-30.
2006: Danielle Duffy; Daniel J Rader
Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol transport.
Circulation 2006;113(8):1140-50.
2006: Amin Majdalawieh; Lei Zhang; Ilia V Fuki; Daniel J Rader; Hyo-Sung Ro
Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2346-51.
2006: Karen O Badellino; Megan L Wolfe; Muredach P Reilly; Daniel J Rader
Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis.
PLoS medicine 2006;3(2):e22.
2006: Snehal U Naik; Xun Wang; Jaqueline S Da Silva; Michael Jaye; Colin H Macphee; Muredach P Reilly; Jeffrey T Billheimer; George H Rothblat; Daniel J Rader
Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo.
Circulation 2006;113(1):90-7.
2006: Danielle Duffy; Daniel J Rader
High-density lipoprotein cholesterol therapies: the next frontier in lipid management.
Journal of cardiopulmonary rehabilitation 2006;26(1):1-8.
2006: Philippe Szapary; LeAnne T Bloedon; Frederick F Samaha; Danielle Duffy; Megan L Wolfe; Daniel Soffer; Muredach P Reilly; Jesse Chittams; Daniel J Rader
Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(1):182-8.
2005: Zijun Li; Hui Qiao; Corinna Lebherz; Seok-Rye Choi; Xiangyang Zhou; Guangping Gao; Hank F Kung; Daniel J Rader; James M Wilson; Jerry D Glickson; Rong Zhou
Creatine kinase, a magnetic resonance-detectable marker gene for quantification of liver-directed gene transfer.
Human gene therapy 2005;16(12):1429-38.
2005: Lei Zhao; Domenico Pratico'; Daniel J Rader; Colin D Funk
12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway.
Prostaglandins & other lipid mediators 2005;78(1-4):185-93.
2005: William Cain; John S Millar; Adam S Himebauch; Uwe J F Tietge; Cyrille Maugeais; David Usher; Daniel J Rader
Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a].
Journal of lipid research 2005;46(12):2681-91.
2005: Bruce S Sachais; Julie Katz; Joyce Ross; Daniel J Rader
Long-term effects of LDL apheresis in patients with severe hypercholesterolemia.
Journal of clinical apheresis 2005;20(4):252-5.
2005: Weijun Jin; Ilia V Fuki; Nabil G Seidah; Suzanne Benjannet; Jane M Glick; Daniel J Rader
Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase.
The Journal of biological chemistry 2005;280(44):36551-9.
2005: Michael P. Madaio; Rexford S Ahima; Ray Meade; Daniel J Rader; Alberto Mendoza; Min Peng; John E Tomaszewski; Wayne W Hancock; David L Gasser
Glomerular and tubular epithelial defects in kd/kd mice lead to progressive renal failure.
American journal of nephrology 2005;25(6):604-10.
2005: Kamilah Ali; Melissa Middleton; Ellen Puré; Daniel J Rader
Apolipoprotein E suppresses the type I inflammatory response in vivo.
Circulation research 2005;97(9):922-7.
2005: Ryan E Moore; Mohamad Navab; John S Millar; Francesca Zimetti; Susan Hama; George H Rothblat; Daniel J Rader
Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation.
Circulation research 2005;97(8):763-71.
2005: YuZhen Zhang; Jaqueline R Da Silva; Muredach Reilly; Jeffrey T Billheimer; George H Rothblat; Daniel J Rader
Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo.
The Journal of clinical investigation 2005;115(10):2870-4.
2005: John S Millar; Debra Cromley; Mary G McCoy; Daniel J Rader; Jeffrey T Billheimer
Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339.
Journal of lipid research 2005;46(9):2023-8.
2005: Muredach P Reilly; Andrea S Foulkes; Megan L Wolfe; Daniel J Rader
Higher order lipase gene association with plasma triglycerides.
Journal of lipid research 2005;46(9):1914-22.
2005: Richard L Dunbar; Daniel J Rader
Demystifying triglycerides: a practical approach for the clinician.
Cleveland Clinic journal of medicine 2005;72(8):661-6, 670-2, 674-5 passim.
2005: Uli C Broedl; Daniel J Rader
Gene therapy for lipoprotein disorders.
Expert opinion on biological therapy 2005;5(8):1029-38.
2005: Uli C Broedl; Weijun Jin; Dawn Marchadier; Anthony Secreto; Daniel J Rader
Tissue-specific expression pattern of human endothelial lipase in transgenic mice.
Atherosclerosis 2005;181(2):271-4.
2005: Sylvia E Rosas; Korlei Mensah; Rachel B Weinstein; Scarlett Bellamy; Daniel J Rader
Coronary artery calcification in renal transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(8):1942-7.
2005: Danielle Duffy; Daniel J Rader
Drugs in development: targeting high-density lipoprotein metabolism and reverse cholesterol transport.
Current opinion in cardiology 2005;20(4):301-6.
2005: Michael Lehrke; Corinna Lebherz; Segan C Millington; Hong-Ping Guan; John Millar; Daniel J Rader; James M Wilson; Mitchell Lazar
Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha.
Cell metabolism 2005;1(5):297-308.
2005: Margaret E Brousseau; Margaret R Diffenderfer; John S Millar; Chorthip Nartsupha; Bela F Asztalos; Francine K Welty; Megan L Wolfe; Mats Rudling; Ingemar Björkhem; Bo Angelin; James P Mancuso; Andres G Digenio; Daniel J Rader; Ernst Schaefer
Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(5):1057-64.
2005: A Jahangiri; Daniel J Rader; Dawn Marchadier; Linda K Curtiss; D J Bonnet; Kerry-Anne Rye
Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I.
Journal of lipid research 2005;46(5):896-903.
2005: Daniel J Rader; Ellen Puré
Lipoproteins, macrophage function, and atherosclerosis: beyond the foam cell?
Cell metabolism 2005;1(4):223-30.
2005: Daniel J Rader
Novel approaches to the treatment of dyslipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(3):480-1.
2005: John S Millar; Cyrille Maugeais; Katsunori Ikewaki; Daniel M Kolansky; Hugh Barrett; Elaine C Budreck; Raymond C Boston; Norio Tada; Seibu Mochizuki; Joep C Defesche; James M Wilson; Daniel J Rader
Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(3):560-5.
2005: Muredach P Reilly; Michael Lehrke; Megan L Wolfe; Anand Rohatgi; Mitchell Lazar; Daniel J Rader
Resistin is an inflammatory marker of atherosclerosis in humans.
Circulation 2005;111(7):932-9.
2005: Bonnie Ky; Daniel J Rader
The effects of statin therapy on plasma markers of inflammation in patients without vascular disease.
Clinical cardiology 2005;28(2):67-70.
2004: Karine M Egan; John A Lawson; Susanne Fries; Beverly H Koller; Daniel J Rader; Emer M Smyth; garret fitzgerald
COX-2-derived prostacyclin confers atheroprotection on female mice.
Science (New York, N.Y.) 2004;306(5703):1954-7.
2004: Muredach P Reilly; Megan L Wolfe; Jennifer Dykhouse; Karthik Reddy; A Russell Localio; Daniel J Rader
Intercellular adhesion molecule 1 (ICAM-1) gene variant is associated with coronary artery calcification independent of soluble ICAM-1 levels.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2004;52(8):515-22.
2004: Uli C Broedl; Weijun Jin; Ilia V Fuki; Jane M Glick; Daniel J Rader
Structural basis of endothelial lipase tropism for HDL.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(15):1891-3.
2004: Michael Lehrke; Muredach P Reilly; Segan C Millington; Nayyar Iqbal; Daniel J Rader; Mitchell Lazar
An inflammatory cascade leading to hyperresistinemia in humans.
PLoS medicine 2004;1(2):e45.
2004: Gwen C Miller; Christopher J Long; Ekaterina D Bojilova; Dawn Marchadier; Karen O Badellino; Nadine Blanchard; Ilia V Fuki; Jane M Glick; Daniel J Rader
Role of N-linked glycosylation in the secretion and activity of endothelial lipase.
Journal of lipid research 2004;45(11):2080-7.
2004: Daniela Caiazza; Anisa Jahangiri; Daniel J Rader; Dawn Marchadier; Kerry-Anne Rye
Apolipoproteins regulate the kinetics of endothelial lipase-mediated hydrolysis of phospholipids in reconstituted high-density lipoproteins.
Biochemistry 2004;43(37):11898-905.
2004: Prakash Seshadri; Nayyar Iqbal; Linda Stern; Monica Williams; Kathryn L Chicano; Denise A Daily; Joyce McGrory; Edward J Gracely; Daniel J Rader; Frederick F Samaha
A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity.
The American journal of medicine 2004;117(6):398-405.
2004: Lei Zhao; Michael P W Moos; Rolf Gräbner; Frédérique Pédrono; Jinjin Fan; Brigitte Kaiser; Nicole John; Sandra Schmidt; Rainer Spanbroek; Katharina Lötzer; Li Huang; Jisong Cui; Daniel J Rader; Jilly F Evans; Andreas J R Habenicht; Colin D Funk
The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.
Nature medicine 2004;10(9):966-73.
2004: Daniel J Rader
Inhibition of cholesteryl ester transfer protein activity: a new therapeutic approach to raising high-density lipoprotein.
Current atherosclerosis reports 2004;6(5):398-405.
2004: Muredach P Reilly; Megan L Wolfe; Thomas Rhodes; Cynthia Girman; Nehal Mehta; Daniel J Rader
Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis.
Circulation 2004;110(7):803-9.
2004: Philippe Szapary; Daniel J Rader
The triglyceride-high-density lipoprotein axis: an important target of therapy?
American heart journal 2004;148(2):211-21.
2004: Muredach P Reilly; Nayyar Iqbal; Mark H Schutta; Megan L Wolfe; Monique Scally; A Russell Localio; Daniel J Rader; Stephen E Kimmel
Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2004;89(8):3872-8.
2004: Uli C Broedl; Weijun Jin; Daniel J Rader
Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation.
Trends in cardiovascular medicine 2004;14(5):202-6.
2004: Karen O Badellino; Daniel J Rader
The role of endothelial lipase in high-density lipoprotein metabolism.
Current opinion in cardiology 2004;19(4):392-5.
2004: Katsunori Ikewaki; William Cain; Fairwell Thomas; Robert D Shamburek; Loren A Zech; David Usher; H Bryan Brewer; Daniel J Rader
Abnormal in vivo metabolism of apoB-containing lipoproteins in human apoE deficiency.
Journal of lipid research 2004;45(7):1302-11.
2004: Uli C Broedl; Cyrille Maugeais; John S Millar; Weijun Jin; Ryan E Moore; Ilia V Fuki; Dawn Marchadier; Jane M Glick; Daniel J Rader
Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins.
Circulation research 2004;94(12):1554-61.
2004: Karen L Teff; Sharon S Elliott; Matthias H Tschöp; Timothy J Kieffer; Daniel J Rader; Mark L Heiman; Raymond R Townsend; Nancy L Keim; David A D'Alessio; Peter J Havel
Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.
The Journal of clinical endocrinology and metabolism 2004;89(6):2963-72.
2004: Corinna Lebherz; Guangping Gao; Jean-Pierre Louboutin; John Millar; Daniel J Rader; James M Wilson
Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia.
The journal of gene medicine 2004;6(6):663-72.
2004: Andrew M Tershakovec; Ian Frank; Daniel J Rader
HIV-related lipodystrophy and related factors.
Atherosclerosis 2004;174(1):1-10.
2004: Margaret E Brousseau; Ernst Schaefer; Megan L Wolfe; LeAnne T Bloedon; Andres G Digenio; Ronald W Clark; James P Mancuso; Daniel J Rader
Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol.
The New England journal of medicine 2004;350(15):1505-15.
2004: Muredach P Reilly; Megan L Wolfe; A Russell Localio; Daniel J Rader
Coronary artery calcification and cardiovascular risk factors: impact of the analytic approach.
Atherosclerosis 2004;173(1):69-78.
2004: Devashish Kothapalli; Ilia V Fuki; Kamilah Ali; Sheryl A Stewart; Liang Zhao; Ron Yahil; David Kwiatkowski; Elizabeth A Hawthorne; garret fitzgerald; Michael C Phillips; Sissel Lund-Katz; Ellen Puré; Daniel J Rader; Richard K Assoian
Antimitogenic effects of HDL and APOE mediated by Cox-2-dependent IP activation.
The Journal of clinical investigation 2004;113(4):609-18.
2004: Patricia G Yancey; Masa-aki Kawashiri; Ryan Moore; Jane M Glick; David L Williams; Margery A Connelly; Daniel J Rader; George H Rothblat
In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux.
Journal of lipid research 2004;45(2):337-46.
2004: L Bastone; M Reilly; Daniel J Rader; Andrea S Foulkes
MDR and PRP: a comparison of methods for high-order genotype-phenotype associations.
Human heredity 2004;58(2):82-92.
2004: Douglas S Jacoby; Emile R Mohler III; Daniel J Rader
Noninvasive atherosclerosis imaging for predicting cardiovascular events and assessing therapeutic interventions.
Current atherosclerosis reports 2004;6(1):20-6.
2003: MyNgan Duong; Maria Psaltis; Daniel J Rader; Dawn Marchadier; Philip J Barter; Kerry-Anne Rye
Evidence that hepatic lipase and endothelial lipase have different substrate specificities for high-density lipoprotein phospholipids.
Biochemistry 2003;42(46):13778-85.
2003: Cyrille Maugeais; Uwe J F Tietge; Uli C Broedl; Dawn Marchadier; William Cain; Mary G McCoy; Sissel Lund-Katz; Jane M Glick; Daniel J Rader
Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase.
Circulation 2003;108(17):2121-6.
2003: Uli C Broedl; Cyrille Maugeais; Dawn Marchadier; Jane M Glick; Daniel J Rader
Effects of nonlipolytic ligand function of endothelial lipase on high density lipoprotein metabolism in vivo.
The Journal of biological chemistry 2003;278(42):40688-93.
2003: Marina Cuchel; Daniel J Rader
Genetics of increased HDL cholesterol levels: insights into the relationship between HDL metabolism and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(10):1710-2.
2003: Ryan E Moore; Masa-aki Kawashiri; Ken Kitajima; Anthony Secreto; John S Millar; Domenico Pratico'; Daniel J Rader
Apolipoprotein A-I deficiency results in markedly increased atherosclerosis in mice lacking the LDL receptor.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(10):1914-20.
2003: Muredach P Reilly; Megan L Wolfe; A Russell Localio; Daniel J Rader
C-reactive protein and coronary artery calcification: The Study of Inherited Risk of Coronary Atherosclerosis (SIRCA).
Arteriosclerosis, thrombosis, and vascular biology 2003;23(10):1851-6.
2003: Muredach P Reilly; Daniel J Rader
The metabolic syndrome: more than the sum of its parts?
Circulation 2003;108(13):1546-51.
2003: Ilia V Fuki; Nadine Blanchard; Weijun Jin; Dawn Marchadier; John S Millar; Jane M Glick; Daniel J Rader
Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway.
The Journal of biological chemistry 2003;278(36):34331-8.
2003: Daniel J Rader
Regulation of reverse cholesterol transport and clinical implications.
The American journal of cardiology 2003;92(4A):42J-49J.
2003: Philippe Szapary; Megan L Wolfe; LeAnne T Bloedon; Andrew J Cucchiara; Ara H DerMarderosian; Michael D Cirigliano; Daniel J Rader
Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial.
JAMA : the journal of the American Medical Association 2003;290(6):765-72.
2003: YuZhen Zhang; Ilaria Zanotti; Muredach P Reilly; Jane M Glick; George H Rothblat; Daniel J Rader
Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo.
Circulation 2003;108(6):661-3.
2003: Sylvia E Rosas; Philippe Szapary; Daniel J Rader
Management of selected lipid abnormalities: hypertriglyceridemia, isolated low HDL-cholesterol, lipoprotein(a), and lipid abnormalities in renal diseases and following solid organ transplantation.
Cardiology clinics 2003;21(3):377-92.
2003: Uwe J F Tietge; Cyrille Maugeais; William Cain; Daniel J Rader
Acute inflammation increases selective uptake of HDL cholesteryl esters into adrenals of mice overexpressing human sPLA2.
American journal of physiology. Endocrinology and metabolism 2003;285(2):E403-11.
2003: Uwe J F Tietge; Karen F Kozarsky; Mary Donahee; Daniel J Rader
A tetracycline-regulated adenoviral expression system for in vivo delivery of transgenes to lung and liver.
The journal of gene medicine 2003;5(7):567-75.
2003: Daniel J Rader; Jonathan Cohen; Helen H Hobbs
Monogenic hypercholesterolemia: new insights in pathogenesis and treatment.
The Journal of clinical investigation 2003;111(12):1795-803.
2003: Douglas S Jacoby; Daniel J Rader
Renin-angiotensin system and atherothrombotic disease: from genes to treatment.
Archives of internal medicine 2003;163(10):1155-64.
2003: Gary D Foster; Holly R Wyatt; James O Hill; Brian G McGuckin; Carrie Brill; B Selma Mohammed; Philippe Szapary; Daniel J Rader; Joel S Edman; Samuel Klein
A randomized trial of a low-carbohydrate diet for obesity.
The New England journal of medicine 2003;348(21):2082-90.
2003: Weijun Jin; Gwo-Shing Sun; Dawn Marchadier; Edelyn Octtaviani; Jane M Glick; Daniel J Rader
Endothelial cells secrete triglyceride lipase and phospholipase activities in response to cytokines as a result of endothelial lipase.
Circulation research 2003;92(6):644-50.
2003: Daniel J Rader
Effects of nonstatin lipid drug therapy on high-density lipoprotein metabolism.
The American journal of cardiology 2003;91(7A):18E-23E.
2003: Daniel J Rader; Michael H Davidson; Richard J Caplan; John S Pears
Lipid and apolipoprotein ratios: association with coronary artery disease and effects of rosuvastatin compared with atorvastatin, pravastatin, and simvastatin.
The American journal of cardiology 2003;91(5A):20C-23C; discussion 23C-24C.
2003: Weijun Jin; John S Millar; Uli C Broedl; Jane M Glick; Daniel J Rader
Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo.
The Journal of clinical investigation 2003;111(3):357-62.
2003: Daniel J Rader
Therapy to reduce risk of coronary heart disease.
Clinical cardiology 2003;26(1):2-8.
2002: Megan L Wolfe; Nayyar Iqbal; Warren B Gefter; Emile R Mohler; Daniel J Rader; Muredach P Reilly
Coronary artery calcification at electron beam computed tomography is increased in asymptomatic type 2 diabetics independent of traditional risk factors.
Journal of cardiovascular risk 2002;9(6):369-76.
2002: Katsunori Ikewaki; Loren A Zech; H Bryan Brewer; Daniel J Rader
Comparative in vivo metabolism of apolipoproteins E2 and E4 in heterozygous apoE2/4 subjects.
The Journal of laboratory and clinical medicine 2002;140(5):369-74.
2002: Masa-aki Kawashiri; YuZhen Zhang; Ellen Puré; Daniel J Rader
Combined effects of cholesterol reduction and apolipoprotein A-I expression on atherosclerosis in LDL receptor deficient mice.
Atherosclerosis 2002;165(1):15-22.
2002: Daniel J Rader
High-density lipoproteins and atherosclerosis.
The American journal of cardiology 2002;90(8A):62i-70i.
2002: Lei Zhao; Carolyn A Cuff; Erin Moss; Ulrike Wille; Tillmann Cyrus; Eric A Klein; Domenico Pratico'; Daniel J Rader; Christopher A Hunter; Ellen Puré; Colin D Funk
Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.
The Journal of biological chemistry 2002;277(38):35350-6.
2002: Andrew S deLemos; Megan L Wolfe; Christopher J Long; Rasheeta Sivapackianathan; Daniel J Rader
Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol.
Circulation 2002;106(11):1321-6.
2002: Weijun Jin; Uli C Broedl; Houshang Monajemi; Jane M Glick; Daniel J Rader
Lipase H, a new member of the triglyceride lipase family synthesized by the intestine.
Genomics 2002;80(3):268-73.
2002: Uwe J F Tietge; Cyrille Maugeais; Sissel Lund-Katz; David Grass; Frederick C deBeer; Daniel J Rader
Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(7):1213-8.
2002: Marina Cuchel; Megan L Wolfe; Andrew S deLemos; Daniel J Rader
The frequency of the cholesteryl ester transfer protein-TaqI B2 allele is lower in African Americans than in Caucasians.
Atherosclerosis 2002;163(1):169-74.
2002: John S Millar; Cyrille Maugeais; Ilia V Fuki; Daniel J Rader
Normal production rate of apolipoprotein B in LDL receptor-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(6):989-94.
2002: Mary G McCoy; Gwo-Shing Sun; Dawn Marchadier; Cyrille Maugeais; Jane M Glick; Daniel J Rader
Characterization of the lipolytic activity of endothelial lipase.
Journal of lipid research 2002;43(6):921-9.
2002: Jonathan A Epstein; Daniel J Rader; Michael S Parmacek
Perspective: cardiovascular disease in the postgenomic era--lessons learned and challenges ahead.
Endocrinology 2002;143(6):2045-50.
2002: Weijun Jin; Dawn Marchadier; Daniel J Rader
Lipases and HDL metabolism.
Trends in endocrinology and metabolism: TEM 2002;13(4):174-8.
2002: Daniel J Rader
Future outlook: changing perspectives on best practice.
The American journal of managed care 2002;8(2 Suppl):S40-4; discussion S45-7.
2002: Marina Cuchel; Daniel J Rader
The role of high density lipoproteins in thrombosis.
TheScientificWorldJournal 2002;2():89-95.
2001: Daniel J Rader
Gene therapy for familial hypercholesterolemia.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2001;11 Suppl 5():40-4.
2001: Carolyn A Cuff; Devashish Kothapalli; Ijeoma Azonobi; S Chun; Y Zhang; R Belkin; C Yeh; A Secreto; Richard K Assoian; Daniel J Rader; Ellen Puré
The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation.
The Journal of clinical investigation 2001;108(7):1031-40.
2001: Peter J Snyder; H Peachey; Jesse A Berlin; Daniel J Rader; David Usher; L Loh; P Hannoush; A Dlewati; JH Holmes; Jill Santanna; Brian L Strom
Effect of transdermal testosterone treatment on serum lipid and apolipoprotein levels in men more than 65 years of age.
The American journal of medicine 2001;111(4):255-60.
2001: Masa-aki Kawashiri; YuZhen Zhang; David Usher; M Reilly; Ellen Puré; Daniel J Rader
Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice.
Journal of lipid research 2001;42(6):943-50.
2001: Tillmann Cyrus; Domenico Pratico'; Lei Zhao; Joseph L Witztum; Daniel J Rader; Joshua Rokach; garret fitzgerald; Colin D Funk
Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice.
Circulation 2001;103(18):2277-82.
2001: Philippe Szapary; Daniel J Rader
Pharmacological management of high triglycerides and low high-density lipoprotein cholesterol.
Current opinion in pharmacology 2001;1(2):113-20.
2001: emma meagher; Daniel J Rader
Antioxidant therapy and atherosclerosis: animal and human studies.
Trends in cardiovascular medicine 2001;11(3-4):162-5.
2001: Megan L Wolfe; S F Vartanian; J L Ross; L L Bansavich; Emile R Mohler; emma meagher; CA Friedrich; Daniel J Rader
Safety and effectiveness of Niaspan when added sequentially to a statin for treatment of dyslipidemia.
The American journal of cardiology 2001;87(4):476-9, A7.
2001: Uwe J F Tietge; Gwo-Shing Sun; S Czarnecki; Q Yu; P Lohse; H Du; G A Grabowski; J M Glick; Daniel J Rader
Phenotypic correction of lipid storage and growth arrest in wolman disease fibroblasts by gene transfer of lysosomal acid lipase.
Human gene therapy 2001;12(3):279-89.
2001: Rajendra K Tangirala; D Praticó; garret fitzgerald; S Chun; K Tsukamoto; Cyrille Maugeais; David Usher; Ellen Puré; Daniel J Rader
Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E.
The Journal of biological chemistry 2001;276(1):261-6.
2000: Cyrille Maugeais; Uwe J F Tietge; K Tsukamoto; Jane M Glick; Daniel J Rader
Hepatic apolipoprotein E expression promotes very low density lipoprotein-apolipoprotein B production in vivo in mice.
Journal of lipid research 2000;41(10):1673-9.
2000: Masa-aki Kawashiri; Cyrille Maugeais; Daniel J Rader
High-density lipoprotein metabolism: molecular targets for new therapies for atherosclerosis.
Current atherosclerosis reports 2000;2(5):363-72.
2000: SJ Chen; Daniel J Rader; John Tazelaar; Masa-aki Kawashiri; Guangping Gao; James M Wilson
Prolonged correction of hyperlipidemia in mice with familial hypercholesterolemia using an adeno-associated viral vector expressing very-low-density lipoprotein receptor.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(3):256-61.
2000: Uwe J F Tietge; Cyrille Maugeais; William Cain; David Grass; Jane M Glick; Frederick C de Beer; Daniel J Rader
Overexpression of secretory phospholipase A(2) causes rapid catabolism and altered tissue uptake of high density lipoprotein cholesteryl ester and apolipoprotein A-I.
The Journal of biological chemistry 2000;275(14):10077-84.
2000: Daniel J Rader
Role of coronary calcification scanning in risk factor assessment.
Journal of cardiovascular risk 2000;7(2):89-91.
2000: Daniel J Rader; Michael Jaye
Endothelial lipase: a new member of the triglyceride lipase gene family.
Current opinion in lipidology 2000;11(2):141-7.
2000: Daniel J Rader; Cyrille Maugeais
Genes influencing HDL metabolism: new perspectives and implications for atherosclerosis prevention.
Molecular medicine today 2000;6(4):170-5.
2000: David DeNofrio; S Desai; Daniel J Rader; G Chang; Michael P Kelley; Michael A Acker; Evan Loh
Changes in lipoprotein(a) concentration after orthotopic heart transplantation.
American heart journal 2000;139(4):729-33.
2000: Karen F Kozarsky; Mary Donahee; Jane M Glick; Monty Krieger; Daniel J Rader
Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(3):721-7.
2000: K Tsukamoto; Rajendra K Tangirala; S Chun; David Usher; Ellen Puré; Daniel J Rader
Hepatic expression of apolipoprotein E inhibits progression of atherosclerosis without reducing cholesterol levels in LDL receptor-deficient mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(2):189-94.
2000: K Tsukamoto; Cyrille Maugeais; Jane M Glick; Daniel J Rader
Markedly increased secretion of VLDL triglycerides induced by gene transfer of apolipoprotein E isoforms in apoE-deficient mice.
Journal of lipid research 2000;41(2):253-9.
2000: Daniel J Rader; K A Dugi
The endothelium and lipoproteins: insights from recent cell biology and animal studies.
Seminars in thrombosis and hemostasis 2000;26(5):521-8.
2000: Daniel J Rader; Sylvia E Rosas
Management of selected lipid abnormalities. Hypertriglyceridemia, low HDL cholesterol, lipoprotein(a), in thyroid and renal diseases, and post-transplantation.
The Medical clinics of North America 2000;84(1):43-61.
1999: Kurt T Barnhart; E Freeman; Jeane Ann Grisso; Daniel J Rader; Mary D Sammel; Shiv Kapoor; J E Nestler
The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life.
The Journal of clinical endocrinology and metabolism 1999;84(11):3896-902.
1999: Uwe J F Tietge; Ahmed Bakillah; Cyrille Maugeais; K Tsukamoto; M Hussain; Daniel J Rader
Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B.
Journal of lipid research 1999;40(11):2134-9.
1999: Rajendra K Tangirala; K Tsukamoto; S H Chun; David Usher; Ellen Puré; Daniel J Rader
Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice.
Circulation 1999;100(17):1816-22.
1999: K Tsukamoto; Rajendra K Tangirala; S H Chun; Ellen Puré; Daniel J Rader
Rapid regression of atherosclerosis induced by liver-directed gene transfer of ApoE in ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2162-70.
1999: Daniel J Rader
Noninvasive procedures for subclinical atherosclerosis risk assessment.
The American journal of medicine 1999;107(2A):25S-27S.
1999: CA Friedrich; Daniel J Rader
Management of lipid disorders.
Rheumatic diseases clinics of North America 1999;25(3):507-20.
1999: Daniel J Rader; Uwe J F Tietge
Gene therapy for dyslipidemia: clinical prospects.
Current atherosclerosis reports 1999;1(1):58-69.
1999: Tillmann Cyrus; Joseph L Witztum; Daniel J Rader; Rajendra K Tangirala; S Fazio; M F Linton; Colin D Funk
Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice.
The Journal of clinical investigation 1999;103(11):1597-604.
1999: Daniel J Rader; Steven M Haffner
Role of fibrates in the management of hypertriglyceridemia.
The American journal of cardiology 1999;83(9B):30F-35F.
1999: Daniel J Rader
Pathophysiology and management of low high-density lipoprotein cholesterol.
The American journal of cardiology 1999;83(9B):22F-24F.
1999: Michael Jaye; K J Lynch; John A Krawiec; Dawn Marchadier; Cyrille Maugeais; K Doan; V South; Dilip Amin; Mark H Perrone; Daniel J Rader
A novel endothelial-derived lipase that modulates HDL metabolism.
Nature genetics 1999;21(4):424-8.
1999: H Hosoai; Nancy R Webb; Jane M Glick; Uwe J F Tietge; M S Purdom; Frederick C de Beer; Daniel J Rader
Expression of serum amyloid A protein in the absence of the acute phase response does not reduce HDL cholesterol or apoA-I levels in human apoA-I transgenic mice.
Journal of lipid research 1999;40(4):648-53.
1999: Emile R Mohler; Norman Delanty; Daniel J Rader; EC Raps
Statins and cerebrovascular disease: plaque attack to prevent brain attack.
Vascular medicine (London, England) 1999;4(4):269-72.
1998: Muredach P Reilly; Domenico Pratico'; N Delanty; G DiMinno; E Tremoli; Daniel J Rader; S Kapoor; Joshua Rokach; J Lawson; garret fitzgerald
Increased formation of distinct F2 isoprostanes in hypercholesterolemia.
Circulation 1998;98(25):2822-8.
1998: Domenico Pratico'; Rajendra K Tangirala; Daniel J Rader; Joshua Rokach; garret fitzgerald
Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice.
Nature medicine 1998;4(10):1189-92.
1998: G Chang; David DeNofrio; S Desai; Michael P Kelley; Daniel J Rader; Michael A Acker; Evan Loh
Lipoprotein(a) levels and heart transplantation atherosclerosis.
American heart journal 1998;136(2):329-34.
1997: K Tsukamoto; K G Hiester; P Smith; David Usher; Jane M Glick; Daniel J Rader
Comparison of human apoA-I expression in mouse models of atherosclerosis after gene transfer using a second generation adenovirus.
Journal of lipid research 1997;38(9):1869-76.
1997: K Tsukamoto; P Smith; Jane M Glick; Daniel J Rader
Liver-directed gene transfer and prolonged expression of three major human ApoE isoforms in ApoE-deficient mice.
The Journal of clinical investigation 1997;100(1):107-14.
1997: Abd Al-Roof Higazi; Ehud Lavi; Khalil Bdeir; AM Ulrich; Dara G Jamieson; Daniel J Rader; David Usher; W Kane; T Ganz; Douglas B Cines
Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells.
Blood 1997;89(12):4290-8.
1996: Daniel J Rader; Katsunori Ikewaki
Unravelling high density lipoprotein-apolipoprotein metabolism in human mutants and animal models.
Current opinion in lipidology 1996;7(3):117-23.
1996: Katsunori Ikewaki; Loren A Zech; H Bryan Brewer; Daniel J Rader
ApoA-II kinetics in humans using endogenous labeling with stable isotopes: slower turnover of apoA-II compared with the exogenous radiotracer method.
Journal of lipid research 1996;37(2):399-407.
1996: Steven E Raper; M Grossman; Daniel J Rader; Jess G Thoene; B J Clark; Daniel M Kolansky; D W Muller; James M Wilson
Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial hypercholesterolemia.
Annals of surgery 1996;223(2):116-26.
1995: G A Aguie; Daniel J Rader; Véronique Clavey; M G Traber; G Torpier; H J Kayden; Jean-Charles Fruchart; H B Brewer; Graciela Castro
Lipoproteins containing apolipoprotein B isolated from patients with abetalipoproteinemia and homozygous hypobetalipoproteinemia: identification and characterization.
Atherosclerosis 1995;118(2):183-91.
1995: D G Jamieson; David Usher; Daniel J Rader; Ehud Lavi
Apolipoprotein(a) deposition in atherosclerotic plaques of cerebral vessels. A potential role for endothelial cells in lesion formation.
The American journal of pathology 1995;147(6):1567-74.
1995: M Grossman; Daniel J Rader; D W Muller; Daniel M Kolansky; Karen F Kozarsky; B J Clark; E A Stein; P J Lupien; H B Brewer; Steven E Raper
A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia.
Nature medicine 1995;1(11):1148-54.
1995: Katsunori Ikewaki; Masato Nishiwaki; T Sakamoto; T Ishikawa; T Fairwell; Loren A Zech; M Nagano; H Nakamura; H Bryan Brewer; Daniel J Rader
Increased catabolic rate of low density lipoproteins in humans with cholesteryl ester transfer protein deficiency.
The Journal of clinical investigation 1995;96(3):1573-81.
1995: W Bartens; Daniel J Rader; GD Talley; H Bryan Brewer
Lipoprotein (a) in patients with hyperlipidaemia.
European journal of clinical investigation 1995;25(9):647-53.
1995: Daniel J Rader; W A Mann; W Cain; Hans Georg Kraft; David Usher; Loren A Zech; Jeffrey M Hoeg; J Davignon; P Lupien; M Grossman
The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans.
The Journal of clinical investigation 1995;95(3):1403-8.
1995: Katsunori Ikewaki; Loren A Zech; M Kindt; H Bryan Brewer; Daniel J Rader
Apolipoprotein A-II production rate is a major factor regulating the distribution of apolipoprotein A-I among HDL subclasses LpA-I and LpA-I:A-II in normolipidemic humans.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(3):306-12.
1995: S I Skarlatos; Nicolas Duverger; Daniel J Rader; Howard S Kruth
Cholesterol efflux from human monocyte-derived macrophages in the presence of LpA-I:A-II.
Biochimica et biophysica acta 1995;1270(1):19-25.
1995: Nicolas Duverger; Daniel J Rader; Katsunori Ikewaki; Masato Nishiwaki; T Sakamoto; T Ishikawa; M Nagano; H Nakamura; H Bryan Brewer
Characterization of high-density apolipoprotein particles A-I and A-I:A-II isolated from humans with cholesteryl ester transfer protein deficiency.
European journal of biochemistry / FEBS 1995;227(1-2):123-9.
1994: Bruno Vergès; Daniel J Rader; J Schaefer; L Zech; M Kindt; T Fairwell; Philippe Gambert; H Bryan Brewer
In vivo metabolism of apolipoprotein A-IV in severe hypertriglyceridemia: a combined radiotracer and stable isotope kinetic study.
Journal of lipid research 1994;35(12):2280-91.
1994: Nicolas Duverger; Daniel J Rader; H Bryan Brewer
Distribution of subclasses of HDL containing apoA-I without apoA-II (LpA-I) in normolipidemic men and women.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(10):1594-9.
1994: Katsunori Ikewaki; Daniel J Rader; Loren A Zech; H Bryan Brewer
In vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: implications for the roles of apolipoproteins B and E in HDL metabolism.
Journal of lipid research 1994;35(10):1809-19.
1994: W Bartens; Daniel J Rader; GD Talley; H Bryan Brewer
Decreased plasma levels of lipoprotein(a) in patients with hypertriglyceridemia.
Atherosclerosis 1994;108(2):149-7.
1994: Daniel J Rader; Jeffrey M Hoeg; H Bryan Brewer
Quantitation of plasma apolipoproteins in the primary and secondary prevention of coronary artery disease.
Annals of internal medicine 1994;120(12):1012-25.
1994: Daniel J Rader; W Cain; Katsunori Ikewaki; GD Talley; Loren A Zech; David Usher; H Bryan Brewer
The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate.
The Journal of clinical investigation 1994;93(6):2758-63.
1994: Daniel J Rader; Katsunori Ikewaki; Nicolas Duverger; H Schmidt; Peter Pritchard; Jiri Frohlich; M Clerc; M F Dumon; T Fairwell; L Zech
Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease.
The Journal of clinical investigation 1994;93(1):321-30.
1994: David Usher; C Swanson; Daniel J Rader; J Krämer; H Bryan Brewer
A comparison of Lp(a) levels in fresh and frozen plasma using ELISAs with either anti-apo(a) or anti-apoB reporting antibodies.
Chemistry and physics of lipids 1994;67-68():243-8.
1994: Salvatore Benvenga; H J Cahnmann; Daniel J Rader; M Kindt; A Facchiano; Jacob Robbins
Thyroid hormone binding to isolated human apolipoproteins A-II, C-I, C-II, and C-III: homology in thyroxine binding sites.
Thyroid : official journal of the American Thyroid Association 1994;4(3):261-7.
1994: Salvatore Benvenga; H J Cahnmann; Daniel J Rader; M Kindt; A Facchiano; Jacob Robbins
Thyroid hormone binding to isolated human apolipoproteins A-II, C-I, C-II, and C-III: homology in thyroxine binding sites.
Thyroid : official journal of the American Thyroid Association 1994;4(4):511.
1993: Daniel J Rader; Katsunori Ikewaki; Nicolas Duverger; IM Feuerstein; L Zech; William E Connor; H Bryan Brewer
Very low high-density lipoproteins without coronary atherosclerosis.
Lancet 1993;342(8885):1455-8.
1993: Katsunori Ikewaki; Daniel J Rader; Juergen R Schaefer; T Fairwell; Loren A Zech; H Bryan Brewer
Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods.
Journal of lipid research 1993;34(12):2207-15.
1993: Nicolas Duverger; Daniel J Rader; P Duchateau; Jean-Charles Fruchart; Graciela Castro; H Bryan Brewer
Biochemical characterization of the three major subclasses of lipoprotein A-I preparatively isolated from human plasma.
Biochemistry 1993;32(46):12372-9.
1993: Daniel J Rader; Juergen R Schaefer; P Lohse; Katsunori Ikewaki; F Thomas; W A Harris; Loren A Zech; C A Dujovne; H Bryan Brewer
Increased production of apolipoprotein A-I associated with elevated plasma levels of high-density lipoproteins, apolipoprotein A-I, and lipoprotein A-I in a patient with familial hyperalphalipoproteinemia.
Metabolism: clinical and experimental 1993;42(11):1429-34.
1993: Katsunori Ikewaki; Daniel J Rader; T Sakamoto; Masato Nishiwaki; N Wakimoto; Juergen R Schaefer; T Ishikawa; T Fairwell; Loren A Zech; H Nakamura
Delayed catabolism of high density lipoprotein apolipoproteins A-I and A-II in human cholesteryl ester transfer protein deficiency.
The Journal of clinical investigation 1993;92(4):1650-8.
1993: J Emmerich; Bruno Vergès; Igor Tauveron; Daniel J Rader; Silvia Santamarina-Fojo; J Shaefer; M Ayrault-Jarrier; P Thiéblot; H Bryan Brewer
Familial HDL deficiency due to marked hypercatabolism of normal apoA-I.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(9):1299-306.
1993: Daniel J Rader; H Bryan Brewer
Abetalipoproteinemia. New insights into lipoprotein assembly and vitamin E metabolism from a rare genetic disease.
JAMA : the journal of the American Medical Association 1993;270(7):865-9.
1993: P Duchateau; Daniel J Rader; Nicolas Duverger; N Theret; C De Geitere; H Bryan Brewer; Jean-Charles Fruchart; Graciela Rosa Castro
Tangier disease: isolation and characterization of LpA-I, LpA-II, LpA-I: A-II and LpA-IV particles from plasma.
Biochimica et biophysica acta 1993;1182(1):30-6.
1993: Daniel J Rader; J Schäfer; P Lohse; B Verges; M Kindt; Loren A Zech; A Steinmetz; H Bryan Brewer
Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein.
The Journal of clinical investigation 1993;92(2):1009-17.
1993: Daniel J Rader; W Cain; Loren A Zech; David Usher; H Bryan Brewer
Variation in lipoprotein(a) concentrations among individuals with the same apolipoprotein (a) isoform is determined by the rate of lipoprotein(a) production.
The Journal of clinical investigation 1993;91(2):443-7.
1993: HARVEY KLEIN; P Lohse; Nicolas Duverger; J J Albers; Daniel J Rader; Loren A Zech; Silvia Santamarina-Fojo; H Bryan Brewer
Two different allelic mutations in the lecithin:cholesterol acyltransferase (LCAT) gene resulting in classic LCAT deficiency: LCAT (tyr83-->stop) and LCAT (tyr156-->asn).
Journal of lipid research 1993;34(1):49-58.
1992: Salvatore Benvenga; H J Cahnmann; Daniel J Rader; M Kindt; Jacob Robbins
Thyroxine binding to the apolipoproteins of high density lipoproteins HDL2 and HDL3.
Endocrinology 1992;131(6):2805-11.
1992: S L Mautner; J A Sanchez; Daniel J Rader; G C Mautner; V J Ferrans; D S Fredrickson; H Bryan Brewer; W C Roberts
The heart in Tangier disease. Severe coronary atherosclerosis with near absence of high-density lipoprotein cholesterol.
American journal of clinical pathology 1992;98(2):191-8.
1992: P Lohse; Daniel J Rader; H Bryan Brewer
Heterozygosity for apolipoprotein E-4Philadelphia(Glu13----Lys, Arg145----Cys) is associated with incomplete dominance of type III hyperlipoproteinemia.
The Journal of biological chemistry 1992;267(19):13642-6.
1992: Juergen R Schaefer; Daniel J Rader; Katsunori Ikewaki; T Fairwell; Loren A Zech; M R Kindt; J Davignon; R E Gregg; H Bryan Brewer
In vivo metabolism of apolipoprotein A-I in a patient with homozygous familial hypercholesterolemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(7):843-8.
1992: Daniel J Rader; R E Gregg; M S Meng; Juergen R Schaefer; Loren A Zech; M D Benson; H Bryan Brewer
In vivo metabolism of a mutant apolipoprotein, apoA-IIowa, associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis.
Journal of lipid research 1992;33(5):755-63.
1992: Y Shibusawa; Yoichiro Ito; Katsunori Ikewaki; Daniel J Rader; H Bryan Brewer
Counter-current chromatography of lipoproteins with a polymer phase system using the cross-axis synchronous coil planet centrifuge.
Journal of chromatography 1992;596(1):118-22.
1991: Daniel J Rader; Graciela Castro; Loren A Zech; Jean-Charles Fruchart; H Bryan Brewer
In vivo metabolism of apolipoprotein A-I on high density lipoprotein particles LpA-I and LpA-I,A-II.
Journal of lipid research 1991;32(11):1849-59.
1991: P Lohse; M R Kindt; Daniel J Rader; H Bryan Brewer
Three genetic variants of human plasma apolipoprotein A-IV. apoA-IV-1(Thr347----Ser), apoA-IV-0(Lys167----Glu,Gln360----His), and apoA-IV-3(Glu165----Lys).
The Journal of biological chemistry 1991;266(21):13513-8.
1991: H Bryan Brewer; Daniel J Rader; Jeffrey M Hoeg; A Mann; G Tennyson
Recent advances in lipoprotein metabolism and the genetic dyslipoproteinemias.
Advances in experimental medicine and biology 1991;285():237-44.
1991: H Bryan Brewer; Daniel J Rader
HDL: structure, function and metabolism.
Progress in lipid research 1991;30(2-3):139-44.
1990: P Lohse; M R Kindt; Daniel J Rader; H Bryan Brewer
Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1.
The Journal of biological chemistry 1990;265(21):12734-9.
1990: P Lohse; M R Kindt; Daniel J Rader; H Bryan Brewer
Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene.
The Journal of biological chemistry 1990;265(17):10061-4.
1990: J R Schaeffer; Daniel J Rader; R E Gregg; T Fairwell; Loren A Zech; M R Kindt; M D Benson; H Bryan Brewer
In vivo protein metabolism utilizing stable isotopes and mass spectrometry: a new approach to the study of mutant proteins in humans.
Transactions of the Association of American Physicians 1990;103():187-94.