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Sheena Radford

Research Profile

Physiology

Protein Folding

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TOP 3
Claire J Sarell; Peter G Stockley; Yongchao Su; Lucy A Woods; Alison E Ashcroft; Galia T Debelouchina; Robert G Griffin; Sheena E Radford
Expanding the repertoire of amyloid polymorphs by co-polymerization of related protein precursors.
Oliver E Farrance; Eleanore Hann; Nicholas G Housden; Renata Kaminska; Colin Kleanthous; Sheena E Radford; Sasha R Derrington; David J Brockwell
A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein.
Jillian Madine; Matthew R Hicks; Maya J Pandya; Sheena E Radford; Alison Rodger; Edwin A Yates; David A Middleton
Site-specific identification of an aβ fibril-heparin interaction site by using solid-state NMR spectroscopy.

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All Publications

2013: Claire J Sarell; Peter G Stockley; Yongchao Su; Lucy A Woods; Alison E Ashcroft; Galia T Debelouchina; Robert G Griffin; Sheena E Radford
Expanding the repertoire of amyloid polymorphs by co-polymerization of related protein precursors.
The Journal of biological chemistry 2013;288(10):7327-37.
2013: Oliver E Farrance; Eleanore Hann; Nicholas G Housden; Renata Kaminska; Colin Kleanthous; Sheena E Radford; Sasha R Derrington; David J Brockwell
A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein.
PLoS biology 2013;11(2):e1001489.
2012: Jillian Madine; Matthew R Hicks; Maya J Pandya; Sheena E Radford; Alison Rodger; Edwin A Yates; David A Middleton
Site-specific identification of an aβ fibril-heparin interaction site by using solid-state NMR spectroscopy.
Angewandte Chemie (International ed. in English) 2012;51(52):13140-3.
2012: Lilia Milanesi; Elena V Orlova; Sheena E Radford; Andrew L Hellewell; Eric W Hewitt; Raz Jelinek; Tania Sheynis; Wei-Feng Xue; Helen R Saibil
Direct three-dimensional visualization of membrane disruption by amyloid fibrils.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(50):20455-60.
2012: Aneika C Leney; Lindsay M McMorran; Sheena E Radford; Alison E Ashcroft
Amphipathic polymers enable the study of functional membrane proteins in the gas phase.
Analytical chemistry 2012;84(22):9841-7.
2012: John P Hodkinson; Sheena E Radford; Alison E Ashcroft
The role of conformational flexibility in β2-microglobulin amyloid fibril formation at neutral pH.
Rapid communications in mass spectrometry : RCM 2012;26(16):1783-92.
2012: Sheena E Radford; Jonathan S Weissman
Special issue: the molecular and cellular mechanisms of amyloidosis.
Journal of molecular biology 2012;421(2-3):139-41.
2012: George W Preston; Sheena E Radford; Alison E Ashcroft; Andrew J Wilson
Covalent cross-linking within supramolecular peptide structures.
Analytical chemistry 2012;84(15):6790-7.
2012: Lijuan Kang; Gina M Moriarty; Sheena E Radford; Lucy A Woods; Alison E Ashcroft; Jean Baum
N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer.
Protein science : a publication of the Protein Society 2012;21(7):911-7.
2012: Bethny Morrissey; Gilles Phan; William J Allen; Alison E Ashcroft; Aneika C Leney; Ana Toste Rêgo; Denis Verger; Gabriel Waksman; Sheena E Radford
The role of chaperone-subunit usher domain interactions in the mechanism of bacterial pilus biogenesis revealed by ESI-MS.
Molecular & cellular proteomics : MCP 2012;11(7):M111.015289.
2012: Gerard H M Huysmans; Sheena E Radford; Stephen A Baldwin; David J Brockwell
Malleability of the folding mechanism of the outer membrane protein PagP: parallel pathways and the effect of membrane elasticity.
Journal of molecular biology 2012;416(3):453-64.
2012: Clare L Pashley; Arnout P Kalverda; Colin Kleanthous; Gareth J Morgan; Gary S Thompson; Sheena E Radford
Conformational properties of the unfolded state of Im7 in nondenaturing conditions.
Journal of molecular biology 2012;416(2):300-18.
2012: Hlengisizwe Ndlovu; Sheena E Radford; Alison E Ashcroft; Sarah A Harris
Effect of sequence variation on the mechanical response of amyloid fibrils probed by steered molecular dynamics simulation.
Biophysical journal 2012;102(3):587-96.
2012: Nathalie M Valette; Sarah A Harris; Sheena E Radford; Stuart L Warriner
Phosphorylation as a tool to modulate aggregation propensity and to predict fibril architecture.
Chembiochem : a European journal of chemical biology 2012;13(2):271-81.
2011: Lucy A Woods; Alison E Ashcroft; Andrew L Hellewell; Eric W Hewitt; Steve W Homans; Geoffrey W Platt; Sheena E Radford
Ligand binding to distinct states diverts aggregation of an amyloid-forming protein.
Nature chemical biology 2011;7(10):730-9.
2011: Timo Eichner; Sheena E Radford
Understanding the complex mechanisms of β2-microglobulin amyloid assembly.
The FEBS journal 2011;278(20):3868-83.
2011: David P Smith; Lucy A Woods; Sheena E Radford; Alison E Ashcroft
Structure and dynamics of oligomeric intermediates in β2-microglobulin self-assembly.
Biophysical journal 2011;101(5):1238-47.
2011: Timo Eichner; Sheena E Radford
A diversity of assembly mechanisms of a generic amyloid fold.
Molecular cell 2011;43(1):8-18.
2011: Aneika C Leney; Gilles Phan; Sheena E Radford; Denis Verger; Gabriel Waksman; William Allen; Alison E Ashcroft
Second order rate constants of donor-strand exchange reveal individual amino acid residues important in determining the subunit specificity of pilus biogenesis.
Journal of the American Society for Mass Spectrometry 2011;22(7):1214-23.
2011: Stuart Knowling; Alice I Bartlett; Sheena E Radford
Dissecting key residues in folding and stability of the bacterial immunity protein 7.
Protein engineering, design & selection : PEDS 2011;24(6):517-23.
2011: Joshua T Berryman; Sheena E Radford; Sarah A Harris
Systematic examination of polymorphism in amyloid fibrils by molecular-dynamics simulation.
Biophysical journal 2011;100(9):2234-42.
2011: Karine Deville; Vicki A M Gold; Alice Robson; Sarah Whitehouse; Richard B Sessions; Stephen A Baldwin; Sheena E Radford; Ian Collinson
The oligomeric state and arrangement of the active bacterial translocon.
The Journal of biological chemistry 2011;286(6):4659-69.
2011: Armin Hoffmann; Daniel Nettels; Jennifer Clark; Alessandro Borgia; Sheena E Radford; Jane Clarke; Benjamin Schuler
Quantifying heterogeneity and conformational dynamics from single molecule FRET of diffusing molecules: recurrence analysis of single particles (RASP).
Physical chemistry chemical physics : PCCP 2011;13(5):1857-71.
2011: Chai Lean Teoh; Chi L L Pham; Nevena Todorova; Andrew Hung; Craig N Lincoln; Emma Lees; Yuen-Han Lam; Katrina Binger; Neil H Thomson; Sheena E Radford; Trevor A Smith; Shirley A Müller; Andreas Engel; Michael D W Griffin; Irene Yarovsky; Paul R Gooley; Geoffrey J Howlett
A structural model for apolipoprotein C-II amyloid fibrils: experimental characterization and molecular dynamics simulations.
Journal of molecular biology 2011;405(5):1246-66.
2011: Michael K Gilson; Sheena E Radford
Protein folding and binding: from biology to physics and back again.
Current opinion in structural biology 2011;21(1):1-3.
2011: Timo Eichner; Arnout P Kalverda; Gary S Thompson; Steve W Homans; Sheena E Radford
Conformational conversion during amyloid formation at atomic resolution.
Molecular cell 2011;41(2):161-72.
2011: Morwenna Y Porter; Sheena E Radford; Katy E Routledge; Eric W Hewitt
Characterization of the response of primary cells relevant to dialysis-related amyloidosis to β2-microglobulin monomer and fibrils.
PloS one 2011;6(11):e27353.
2010: Mark M Chen; Alice I Bartlett; Paul S Nerenberg; Claire T Friel; Christian P R Hackenberger; Collin M Stultz; Sheena E Radford; Barbara Imperiali
Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(52):22528-33.
2010: Galia T Debelouchina; Geoffrey W Platt; Sheena E Radford; Marvin J Bayro; Robert G Griffin
Intermolecular alignment in β2-microglobulin amyloid fibrils.
Journal of the American Chemical Society 2010;132(48):17077-9.
2010: Galia T Debelouchina; Geoffrey W Platt; Marvin J Bayro; Sheena E Radford; Robert G Griffin
Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies.
Journal of the American Chemical Society 2010;132(30):10414-23.
2010: Carol L Ladner; Min Chen; David P Smith; Geoffrey W Platt; Sheena E Radford; Ralf Langen
Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling.
The Journal of biological chemistry 2010;285(22):17137-47.
2010: Sara D Pugh; Christopher Gell; D Alastair Smith; Sheena E Radford; David J Brockwell
Single-molecule studies of the Im7 folding landscape.
Journal of molecular biology 2010;398(1):132-45.
2010: David P Smith; Sheena E Radford; Alison E Ashcroft
Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(15):6794-8.
2010: Alice I Bartlett; Sheena E Radford
Desolvation and development of specific hydrophobic core packing during Im7 folding.
Journal of molecular biology 2010;396(5):1329-45.
2010: Gerard H M Huysmans; Stephen A Baldwin; David J Brockwell; Sheena E Radford
The transition state for folding of an outer membrane protein.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):4099-104.
2010: Wei-Feng Xue; Andrew L Hellewell; Eric W Hewitt; Sheena E Radford
Fibril fragmentation in amyloid assembly and cytotoxicity: when size matters.
Prion 2010;4(1):20-5.
2009: Linda Foit; Gareth J Morgan; Maximilian J Kern; Lenz R Steimer; Annekathrin A von Hacht; James Titchmarsh; Stuart L Warriner; Sheena E Radford; James C A Bardwell
Optimizing protein stability in vivo.
Molecular cell 2009;36(5):861-71.
2009: Wei-Feng Xue; Andrew L Hellewell; Walraj S Gosal; Steve W Homans; Eric W Hewitt; Sheena E Radford
Fibril fragmentation enhances amyloid cytotoxicity.
The Journal of biological chemistry 2009;284(49):34272-82.
2009: Colin A Grant; David J Brockwell; Sheena E Radford; Neil H Thomson
Tuning the elastic modulus of hydrated collagen fibrils.
Biophysical journal 2009;97(11):2985-92.
2009: David P Sadler; Eva Petrik; Yukinori Taniguchi; James R Pullen; Masaru Kawakami; Sheena E Radford; David J Brockwell
Identification of a mechanical rheostat in the hydrophobic core of protein L.
Journal of molecular biology 2009;393(1):237-48.
2009: Stuart E Knowling; Angelo Miguel Figueiredo; Sara B-M Whittaker; Geoffrey R Moore; Sheena E Radford
Amino acid insertion reveals a necessary three-helical intermediate in the folding pathway of the colicin E7 immunity protein Im7.
Journal of molecular biology 2009;392(4):1074-86.
2009: Geoffrey W Platt; Sheena E Radford
Glimpses of the molecular mechanisms of beta2-microglobulin fibril formation in vitro: aggregation on a complex energy landscape.
FEBS letters 2009;583(16):2623-9.
2009: Wei-Feng Xue; Steve W Homans; Sheena E Radford
Amyloid fibril length distribution quantified by atomic force microscopy single-particle image analysis.
Protein engineering, design & selection : PEDS 2009;22(8):489-96.
2009: Joshua T Berryman; Sheena E Radford; Sarah A Harris
Thermodynamic description of polymorphism in Q- and N-rich peptide aggregates revealed by atomistic simulation.
Biophysical journal 2009;97(1):1-11.
2009: Katy E Routledge; Gian Gaetano Tartaglia; Geoffrey W Platt; Michele Vendruscolo; Sheena E Radford
Competition between intramolecular and intermolecular interactions in an amyloid-forming protein.
Journal of molecular biology 2009;389(4):776-86.
2009: Alice I Bartlett; Sheena E Radford
An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms.
Nature structural & molecular biology 2009;16(6):582-8.
2009: Helen E White; Julie L Hodgkinson; Thomas R Jahn; Sara Cohen-Krausz; Walraj S Gosal; Shirley Müller; Elena V Orlova; Sheena E Radford; Helen R Saibil
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils.
Journal of molecular biology 2009;389(1):48-57.
2009: Timo Eichner; Sheena E Radford
A generic mechanism of beta2-microglobulin amyloid assembly at neutral pH involving a specific proline switch.
Journal of molecular biology 2009;386(5):1312-26.
2009: Claire T Friel; D Alastair Smith; Michele Vendruscolo; Joerg Gsponer; Sheena E Radford
The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints.
Nature structural & molecular biology 2009;16(3):318-24.
2009: John Hodkinson; Thomas R Jahn; Sheena E Radford; Alison E Ashcroft
HDX-ESI-MS reveals enhanced conformational dynamics of the amyloidogenic protein beta(2)-microglobulin upon release from the MHC-1.
Journal of the American Society for Mass Spectrometry 2009;20(2):278-86.
2009: Geoffrey W Platt; Wei-Feng Xue; Steve W Homans; Sheena E Radford
Probing dynamics within amyloid fibrils using a novel capping method.
Angewandte Chemie (International ed. in English) 2009;48(31):5705-7.
2008: David P Smith; Jon Anderson; Jeffrey Plante; Alison E Ashcroft; Sheena E Radford; Andrew J Wilson; Martin J Parker
Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation.
Chemical communications (Cambridge, England) 2008;(44):5728-30.
2008: Denis Verger; Rebecca J Rose; Emanuele Paci; Greg Costakes; Tina Daviter; Scott J Hultgren; Han Remaut; Alison E Ashcroft; Sheena E Radford; Gabriel Waksman
Structural determinants of polymerization reactivity of the P pilus adaptor subunit PapF.
Structure (London, England : 1993) 2008;16(11):1724-31.
2008: Jillian Madine; Edward R Jack; Peter G Stockley; Sheena E Radford; Louise C Serpell; David A Middleton
Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction.
Journal of the American Chemical Society 2008;130(45):14990-5001.
2008: Rebecca J Rose; Denis Verger; Tina Daviter; Han Remaut; Emanuele Paci; Gabriel Waksman; Alison E Ashcroft; Sheena E Radford
Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12873-8.
2008: Wei-Feng Xue; Steve W Homans; Sheena E Radford
Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):8926-31.
2008: Thomas R Jahn; Glenys A Tennent; Sheena E Radford
A common beta-sheet architecture underlies in vitro and in vivo beta2-microglobulin amyloid fibrils.
The Journal of biological chemistry 2008;283(25):17279-86.
2008: Geoffrey W Platt; Katy E Routledge; Steve W Homans; Sheena E Radford
Fibril growth kinetics reveal a region of beta2-microglobulin important for nucleation and elongation of aggregation.
Journal of molecular biology 2008;378(1):251-63.
2008: Rebecca J Rose; Thomas S Welsh; Gabriel Waksman; Alison E Ashcroft; Sheena E Radford; Emanuele Paci
Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics.
Journal of molecular biology 2008;375(4):908-19.
2008: Bhavin S Khatri; Katherine Byrne; Masaru Kawakami; David J Brockwell; D Alastair Smith; Sheena E Radford; Tom C B McLeish
Internal friction of single polypeptide chains at high stretch.
Faraday discussions 2008;139():35-51; discussion 105-28, 419-20.
2008: Thomas R Jahn; Sheena E Radford
Folding versus aggregation: polypeptide conformations on competing pathways.
Archives of biochemistry and biophysics 2008;469(1):100-17.
2007: David P Smith; Kevin Giles; Robert H Bateman; Sheena E Radford; Alison E Ashcroft
Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometry.
Journal of the American Society for Mass Spectrometry 2007;18(12):2180-90.
2007: David H J Bunka; Benjamin J Mantle; Isobel J Morten; Glenys A Tennent; Sheena E Radford; Peter G Stockley
Production and characterization of RNA aptamers specific for amyloid fibril epitopes.
The Journal of biological chemistry 2007;282(47):34500-9.
2007: Gerard H M Huysmans; Sheena E Radford; David J Brockwell; Stephen A Baldwin
The N-terminal helix is a post-assembly clamp in the bacterial outer membrane protein PagP.
Journal of molecular biology 2007;373(3):529-40.
2007: Isobel J Morten; Walraj S Gosal; Sheena E Radford; Eric W Hewitt
Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils.
The Journal of biological chemistry 2007;282(40):29691-700.
2007: Victoria L Morton; Claire T Friel; Lucy R Allen; Emanuele Paci; Sheena E Radford
The effect of increasing the stability of non-native interactions on the folding landscape of the bacterial immunity protein Im9.
Journal of molecular biology 2007;371(2):554-68.
2007: Antoni J H Borysik; Isobel J Morten; Sheena E Radford; Eric W Hewitt
Specific glycosaminoglycans promote unseeded amyloid formation from beta2-microglobulin under physiological conditions.
Kidney international 2007;72(2):174-81.
2007: Sara Linse; Celia Cabaleiro-Lago; Wei-Feng Xue; Iseult Lynch; Stina Lindman; Eva Thulin; Sheena E Radford; Kenneth A Dawson
Nucleation of protein fibrillation by nanoparticles.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8691-6.
2007: Eleanore Hann; Nadine Kirkpatrick; Colin Kleanthous; D Alastair Smith; Sheena E Radford; David J Brockwell
The effect of protein complexation on the mechanical stability of Im9.
Biophysical journal 2007;92(9):L79-81.
2007: Sara B-M Whittaker; Graham R Spence; J Günter Grossmann; Sheena E Radford; Geoffrey R Moore
NMR analysis of the conformational properties of the trapped on-pathway folding intermediate of the bacterial immunity protein Im7.
Journal of molecular biology 2007;366(3):1001-15.
2007: David J Brockwell; Sheena E Radford
Intermediates: ubiquitous species on folding energy landscapes?
Current opinion in structural biology 2007;17(1):30-7.
2006: Cécile S Le Duff; Sara B-M Whittaker; Sheena E Radford; Geoffrey R Moore
Characterisation of the conformational properties of urea-unfolded Im7: implications for the early stages of protein folding.
Journal of molecular biology 2006;364(4):824-35.
2006: Andrew M Smith; Thomas R Jahn; Alison E Ashcroft; Sheena E Radford
Direct observation of oligomeric species formed in the early stages of amyloid fibril formation using electrospray ionisation mass spectrometry.
Journal of molecular biology 2006;364(1):9-19.
2006: Tomoko Tezuka-Kawakami; Christopher Gell; David J Brockwell; Sheena E Radford; D Alastair Smith
Urea-induced unfolding of the immunity protein Im9 monitored by spFRET.
Biophysical journal 2006;91(5):L42-4.
2006: Masaru Kawakami; Katherine Byrne; David J Brockwell; Sheena E Radford; D Alastair Smith
Viscoelastic study of the mechanical unfolding of a protein by AFM.
Biophysical journal 2006;91(2):L16-8.
2006: Edward R Jack; Matthew Newsome; Peter G Stockley; Sheena E Radford; David A Middleton
The organization of aromatic side groups in an amyloid fibril probed by solid-state 2H and 19F NMR spectroscopy.
Journal of the American Chemical Society 2006;128(25):8098-9.
2006: Han Remaut; Rebecca J Rose; Thomas J Hannan; Scott J Hultgren; Sheena E Radford; Alison E Ashcroft; Gabriel Waksman
Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism.
Molecular cell 2006;22(6):831-42.
2006: Sheena E Radford
GroEL: More than Just a folding cage.
Cell 2006;125(5):831-3.
2006: Thomas R Jahn; Martin J Parker; Steve W Homans; Sheena E Radford
Amyloid formation under physiological conditions proceeds via a native-like folding intermediate.
Nature structural & molecular biology 2006;13(3):195-201.
2006: Sarah L Myers; Susan Jones; Thomas R Jahn; Isobel J Morten; Glenys A Tennent; Eric W Hewitt; Sheena E Radford
A systematic study of the effect of physiological factors on beta2-microglobulin amyloid formation at neutral pH.
Biochemistry 2006;45(7):2311-21.
2006: Eva S Cobos; Sheena E Radford
Sulfate-induced effects in the on-pathway intermediate of the bacterial immunity protein Im7.
Biochemistry 2006;45(7):2274-82.
2006: Joerg Gsponer; Harri Hopearuoho; Sara B-M Whittaker; Graham R Spence; Geoffrey R Moore; Emanuele Paci; Sheena E Radford; Michele Vendruscolo
Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(1):99-104.
2006: Sarah L Myers; Neil H Thomson; Sheena E Radford; Alison E Ashcroft
Investigating the structural properties of amyloid-like fibrils formed in vitro from beta2-microglobulin using limited proteolysis and electrospray ionisation mass spectrometry.
Rapid communications in mass spectrometry : RCM 2006;20(11):1628-36.
2006: Walraj S Gosal; Sarah L Myers; Sheena E Radford; Neil H Thomson
Amyloid under the atomic force microscope.
Protein and peptide letters 2006;13(3):261-70.
2006: Daniel K West; David J Brockwell; Peter D Olmsted; Sheena E Radford; Emanuele Paci
Mechanical resistance of proteins explained using simple molecular models.
Biophysical journal 2006;90(1):287-97.
2005: Thomas R Jahn; Sheena E Radford
The Yin and Yang of protein folding.
The FEBS journal 2005;272(23):5962-70.
2005: Sheena E Radford; Walraj S Gosal; Geoffrey W Platt
Towards an understanding of the structural molecular mechanism of beta(2)-microglobulin amyloid formation in vitro.
Biochimica et biophysica acta 2005;1753(1):51-63.
2005: Christian P R Hackenberger; Claire T Friel; Sheena E Radford; Barbara Imperiali
Semisynthesis of a glycosylated Im7 analogue for protein folding studies.
Journal of the American Chemical Society 2005;127(37):12882-9.
2005: Walraj S Gosal; Isobel J Morten; Eric W Hewitt; D Alastair Smith; Neil H Thomson; Sheena E Radford
Competing pathways determine fibril morphology in the self-assembly of beta2-microglobulin into amyloid.
Journal of molecular biology 2005;351(4):850-64.
2005: David J Brockwell; Godfrey S Beddard; Emanuele Paci; Daniel K West; Peter D Olmsted; D Alastair Smith; Sheena E Radford
Mechanically unfolding the small, topologically simple protein L.
Biophysical journal 2005;89(1):506-19.
2005: Masaru Kawakami; Katherine Byrne; Bhavin S Khatri; Tom C B McLeish; Sheena E Radford; D Alastair Smith
Viscoelastic measurements of single molecules on a millisecond time scale by magnetically driven oscillation of an atomic force microscope cantilever.
Langmuir : the ACS journal of surfaces and colloids 2005;21(10):4765-72.
2005: Iñigo R Rodriguez-Mendieta; Graham R Spence; Christopher Gell; Sheena E Radford; D Alastair Smith
Ultraviolet resonance Raman studies reveal the environment of tryptophan and tyrosine residues in the native and partially folded states of the E colicin-binding immunity protein Im7.
Biochemistry 2005;44(9):3306-15.
2005: Geoffrey W Platt; Victoria J McParland; Arnout P Kalverda; Steve W Homans; Sheena E Radford
Dynamics in the unfolded state of beta2-microglobulin studied by NMR.
Journal of molecular biology 2005;346(1):279-94.
2005: Susanne Cranz-Mileva; Claire T Friel; Sheena E Radford
Helix stability and hydrophobicity in the folding mechanism of the bacterial immunity protein Im9.
Protein engineering, design & selection : PEDS 2005;18(1):41-50.
2004: Masaru Kawakami; Katherine Byrne; Bhavin S Khatri; Tom C B McLeish; Sheena E Radford; D Alastair Smith
Viscoelastic properties of single polysaccharide molecules determined by analysis of thermally driven oscillations of an atomic force microscope cantilever.
Langmuir : the ACS journal of surfaces and colloids 2004;20(21):9299-303.
2004: Claire T Friel; Godfrey S Beddard; Sheena E Radford
Switching two-state to three-state kinetics in the helical protein Im9 via the optimisation of stabilising non-native interactions by design.
Journal of molecular biology 2004;342(1):261-73.
2004: Graham R Spence; Andrew P Capaldi; Sheena E Radford
Trapping the on-pathway folding intermediate of Im7 at equilibrium.
Journal of molecular biology 2004;341(1):215-26.
2004: Antoni J H Borysik; Sheena E Radford; Alison E Ashcroft
Co-populated conformational ensembles of beta2-microglobulin uncovered quantitatively by electrospray ionization mass spectrometry.
The Journal of biological chemistry 2004;279(26):27069-77.
2004: George Dimitriadis; Adam Drysdale; Jeffrey K Myers; Pooja Arora; Sheena E Radford; Terrence G Oas; D Alastair Smith
Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(11):3809-14.
2004: Stanislaw A Gorski; Cécile S Le Duff; Andrew P Capaldi; Arnout P Kalverda; Godfrey S Beddard; Geoffrey R Moore; Sheena E Radford
Equilibrium hydrogen exchange reveals extensive hydrogen bonded secondary structure in the on-pathway intermediate of Im7.
Journal of molecular biology 2004;337(1):183-93.
2004: Emanuele Paci; Claire T Friel; Kresten Lindorff-Larsen; Sheena E Radford; Martin Karplus; Michele Vendruscolo
Comparison of the transition state ensembles for folding of Im7 and Im9 determined using all-atom molecular dynamics simulations with phi value restraints.
Proteins 2004;54(3):513-25.
2004: Antoni J H Borysik; Paul Read; David R Little; Robert H Bateman; Sheena E Radford; Alison E Ashcroft
Separation of beta2-microglobulin conformers by high-field asymmetric waveform ion mobility spectrometry (FAIMS) coupled to electrospray ionisation mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(19):2229-34.
2003: Jennifer A Siepen; Sheena E Radford; David R Westhead
Beta edge strands in protein structure prediction and aggregation.
Protein science : a publication of the Protein Society 2003;12(10):2348-59.
2003: David J Brockwell; Emanuele Paci; Rebecca C Zinober; Godfrey S Beddard; Peter D Olmsted; D Alastair Smith; Richard N Perham; Sheena E Radford
Pulling geometry defines the mechanical resistance of a beta-sheet protein.
Nature structural biology 2003;10(9):731-7.
2003: Amalia Aggeli; Mark Bell; Lisa M Carrick; Colin W G Fishwick; Richard Harding; Peter J Mawer; Sheena E Radford; Andrew E Strong; Neville Boden
pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases.
Journal of the American Chemical Society 2003;125(32):9619-28.
2003: David P Smith; Susan Jones; Louise C Serpell; Margaret Sunde; Sheena E Radford
A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation.
Journal of molecular biology 2003;330(5):943-54.
2003: Susan Jones; David P Smith; Sheena E Radford
Role of the N and C-terminal strands of beta 2-microglobulin in amyloid formation at neutral pH.
Journal of molecular biology 2003;330(5):935-41.
2003: Neil M Kad; Sarah L Myers; David P Smith; D Alastair Smith; Sheena E Radford; Neil H Thomson
Hierarchical assembly of beta2-microglobulin amyloid in vitro revealed by atomic force microscopy.
Journal of molecular biology 2003;330(4):785-97.
2003: D Alastair Smith; David J Brockwell; Rebecca C Zinober; Anthony W Blake; Godfrey S Beddard; Peter D Olmsted; Sheena E Radford
Unfolding dynamics of proteins under applied force.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2003;361(1805):713-28; discussion 728-30.
2003: Sheena E Radford
Co-translocational misfolding in the ER of living cells.
Nature structural biology 2003;10(3):153-4.
2003: Claire T Friel; Andrew P Capaldi; Sheena E Radford
Structural analysis of the rate-limiting transition states in the folding of Im7 and Im9: similarities and differences in the folding of homologous proteins.
Journal of molecular biology 2003;326(1):293-305.
2003: Susan Jones; James Manning; Neil M Kad; Sheena E Radford
Amyloid-forming peptides from beta2-microglobulin-Insights into the mechanism of fibril formation in vitro.
Journal of molecular biology 2003;325(2):249-57.
2002: Rebecca C Zinober; David J Brockwell; Godfrey S Beddard; Anthony W Blake; Peter D Olmsted; Sheena E Radford; D Alastair Smith
Mechanically unfolding proteins: the effect of unfolding history and the supramolecular scaffold.
Protein science : a publication of the Protein Society 2002;11(12):2759-65.
2002: Alison E Ashcroft; Achim Brinker; Joseph E Coyle; Frank Weber; Markus Kaiser; Luis Moroder; Mark R Parsons; Joachim Jager; Ulrich F Hartl; Manajit Hayer-Hartl; Sheena E Radford
Structural plasticity and noncovalent substrate binding in the GroEL apical domain. A study using electrospay ionization mass spectrometry and fluorescence binding studies.
The Journal of biological chemistry 2002;277(36):33115-26.
2002: Chi H Trinh; David P Smith; Arnout P Kalverda; Simon E V Phillips; Sheena E Radford
Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9771-6.
2002: David J Brockwell; Godfrey S Beddard; John Clarkson; Rebecca C Zinober; Anthony W Blake; John Trinick; Peter D Olmsted; D Alastair Smith; Sheena E Radford
The effect of core destabilization on the mechanical resistance of I27.
Biophysical journal 2002;83(1):458-72.
2002: Luc Bousset; Neil H Thomson; Sheena E Radford; Ronald Melki
The yeast prion Ure2p retains its native alpha-helical conformation upon assembly into protein fibrils in vitro.
The EMBO journal 2002;21(12):2903-11.
2002: Victoria J McParland; Arnout P Kalverda; Steve W Homans; Sheena E Radford
Structural properties of an amyloid precursor of beta(2)-microglobulin.
Nature structural biology 2002;9(5):326-31.
2002: Andrew P Capaldi; Colin Kleanthous; Sheena E Radford
Im7 folding mechanism: misfolding on a path to the native state.
Nature structural biology 2002;9(3):209-16.
2001: Neil M Kad; Neil H Thomson; David P Smith; D Alastair Smith; Sheena E Radford
Beta(2)-microglobulin and its deamidated variant, N17D form amyloid fibrils with a range of morphologies in vitro.
Journal of molecular biology 2001;313(3):559-71.
2001: S A Gorski; Andrew P Capaldi; Colin Kleanthous; Sheena E Radford
Acidic conditions stabilise intermediates populated during the folding of Im7 and Im9.
Journal of molecular biology 2001;312(4):849-63.
2001: David P Smith; Sheena E Radford
Role of the single disulphide bond of beta(2)-microglobulin in amyloidosis in vitro.
Protein science : a publication of the Protein Society 2001;10(9):1775-84.
2001: John Reader; N A Van Nuland; Gary S Thompson; SJ Ferguson; C M Dobson; Sheena E Radford
A partially folded intermediate species of the beta-sheet protein apo-pseudoazurin is trapped during proline-limited folding.
Protein science : a publication of the Protein Society 2001;10(6):1216-24.
2001: N Ferguson; Wei Li; Andrew P Capaldi; Colin Kleanthous; Sheena E Radford
Using chimeric immunity proteins to explore the energy landscape for alpha-helical protein folding.
Journal of molecular biology 2001;307(1):393-405.
2001: Andrew P Capaldi; M C Ramachandra Shastry; Colin Kleanthous; Heinrich Roder; Sheena E Radford
Ultrarapid mixing experiments reveal that Im7 folds via an on-pathway intermediate.
Nature structural biology 2001;8(1):68-72.
2000: Victoria J McParland; Neil M Kad; Arnout P Kalverda; A Brown; P Kirwin-Jones; M G Hunter; Margaret Sunde; Sheena E Radford
Partially unfolded states of beta(2)-microglobulin and amyloid formation in vitro.
Biochemistry 2000;39(30):8735-46.
2000: Susan Jones; John Reader; M Healy; Andrew P Capaldi; Alison E Ashcroft; Arnout P Kalverda; D Alastair Smith; Sheena E Radford
Partially unfolded species populated during equilibrium denaturation of the beta-sheet protein Y74W apo-pseudoazurin.
Biochemistry 2000;39(19):5672-82.
2000: Gary S Thompson; Y C Leung; SJ Ferguson; Sheena E Radford; C Redfield
The structure and dynamics in solution of Cu(I) pseudoazurin from Paracoccus pantotrophus.
Protein science : a publication of the Protein Society 2000;9(5):846-58.
2000: R H Argent; AM Parrott; Philip J Day; Lynne M Roberts; Peter G Stockley; J Michael Lord; Sheena E Radford
Ribosome-mediated folding of partially unfolded ricin A-chain.
The Journal of biological chemistry 2000;275(13):9263-9.
2000: David J Brockwell; D Alastair Smith; Sheena E Radford
Protein folding mechanisms: new methods and emerging ideas.
Current opinion in structural biology 2000;10(1):16-25.
1999: Joseph E Coyle; F L Texter; Alison E Ashcroft; D Masselos; CV Robinson; Sheena E Radford
GroEL accelerates the refolding of hen lysozyme without changing its folding mechanism.
Nature structural biology 1999;6(7):683-90.
1999: Sheena E Radford; C M Dobson
From computer simulations to human disease: emerging themes in protein folding.
Cell 1999;97(3):291-8.
1999: Andrew P Capaldi; SJ Ferguson; Sheena E Radford
The Greek key protein apo-pseudoazurin folds through an obligate on-pathway intermediate.
Journal of molecular biology 1999;286(5):1621-32.
1999: N Ferguson; Andrew P Capaldi; Richard James; Colin Kleanthous; Sheena E Radford
Rapid folding with and without populated intermediates in the homologous four-helix proteins Im7 and Im9.
Journal of molecular biology 1999;286(5):1597-608.
1999: Colin Kleanthous; Ulrike C Kühlmann; Ansgar J Pommer; N Ferguson; Sheena E Radford; Geoffrey R Moore; Richard James; Andrew M Hemmings
Structural and mechanistic basis of immunity toward endonuclease colicins.
Nature structural biology 1999;6(3):243-52.
1999: S K Kulkarni; Alison E Ashcroft; M Carey; D Masselos; CV Robinson; Sheena E Radford
A near-native state on the slow refolding pathway of hen lysozyme.
Protein science : a publication of the Protein Society 1999;8(1):35-44.
1998: Andrew P Capaldi; Sheena E Radford
Kinetic studies of beta-sheet protein folding.
Current opinion in structural biology 1998;8(1):86-92.
1998: Sheena E Radford
What's new in protein folding? EMBO workshop: protein folding and misfolding inside and outside the cell.
Folding & design 1998;3(3):R59-63.
1997: Amalia Aggeli; Mark Bell; Neville Boden; Jeffrey N Keen; Peter F Knowles; Tom C B McLeish; M Pitkeathly; Sheena E Radford
Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes.
Nature 1997;386(6622):259-62.
1997: Joseph E Coyle; J Jaeger; M Gross; CV Robinson; Sheena E Radford
Structural and mechanistic consequences of polypeptide binding by GroEL.
Folding & design 1997;2(6):R93-104.