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Olof Rådmark

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Chemicals & Drugs

Anatomy

Physiology

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Ingela Loell; Ingrid E Lundberg; Jayesh Pandya; Olof Rådmark; Christina Ståhl Hallengren; Mei Zong; Li Alemo Munters; Helene Alexanderson; Andreas E Fasth; Per-Johan Jakobsson; Marina Korotkova
Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis.
P Torregrosa Paredes; Charlotte Admyre; Anders Eklund; Julia Esser; Reidar Grönneberg; Johan Grunewald; A Lukic; M Nord; Olof Rådmark; Q K Rahman; Annika Scheynius; Susanne Gabrielsson
Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma.
Carlo Pergola; Olof Rådmark; Anja Rogge; Lidia Sautebin; Christina Weinigel; Dagmar Barz; Gabriele Dodt; Hinnak Northoff; Oliver Werz
Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes.

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All Publications

2013: Ingela Loell; Ingrid E Lundberg; Jayesh Pandya; Olof Rådmark; Christina Ståhl Hallengren; Mei Zong; Li Alemo Munters; Helene Alexanderson; Andreas E Fasth; Per-Johan Jakobsson; Marina Korotkova
Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis.
Annals of the rheumatic diseases 2013;72(2):293-9.
2012: P Torregrosa Paredes; Charlotte Admyre; Anders Eklund; Julia Esser; Reidar Grönneberg; Johan Grunewald; A Lukic; M Nord; Olof Rådmark; Q K Rahman; Annika Scheynius; Susanne Gabrielsson
Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma.
Allergy 2012;67(7):911-9.
2011: Carlo Pergola; Olof Rådmark; Anja Rogge; Lidia Sautebin; Christina Weinigel; Dagmar Barz; Gabriele Dodt; Hinnak Northoff; Oliver Werz
Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(10):3377-87.
2011: Julia Esser; Ulf Gehrmann; M Dolores Salvado; Anders Wetterholm; Jesper Z Haeggström; Bengt Samuelsson; Susanne Gabrielsson; Annika Scheynius; Olof Rådmark
Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(4):1417-27.
2010: Julia Esser; Ulf Gehrmann; Fabio Luiz D'Alexandri; Alicia M Hidalgo-Estévez; Craig E Wheelock; Annika Scheynius; Susanne Gabrielsson; Olof Rådmark
Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration.
The Journal of allergy and clinical immunology 2010;126(5):1032-40, 1040.e1-4.
2010: Marcus Conrad; Asa Sandin; Heidi Förster; Alexander Seiler; Jeroen Frijhoff; Markus Dagnell; Georg W Bornkamm; Olof Rådmark; Rob Hooft van Huijsduijnen; Pontus Aspenström; Frank Böhmer; Arne Ostman
12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(36):15774-9.
2010: Olof Rådmark; Bengt Samuelsson
Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer.
Journal of internal medicine 2010;268(1):5-14.
2010: Olof Rådmark; Bengt Samuelsson
Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis.
Biochemical and biophysical research communications 2010;396(1):105-10.
2010: Kirsten L Stoffers; Bernd L Sorg; Sabine Seuter; Oliver Rau; Olof Rådmark; Dieter Steinhilber
Calcitriol upregulates open chromatin and elongation markers at functional vitamin D response elements in the distal part of the 5-lipoxygenase gene.
Journal of molecular biology 2010;395(4):884-96.
2010: Julia Esser; Marija Rakonjac Ryge; Bettina Hofmann; Lutz Fischer; Patrick Provost; Gisbert Schneider; Dieter Steinhilber; Bengt Samuelsson; Olof Rådmark
Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.
The Biochemical journal 2010;425(1):265-74.
2010: Careen Katryniok; Nicole Schnur; Ad Gillis; Andreas von Knethen; Bernd L Sorg; Leendert Looijenga; Olof Rådmark; Dieter Steinhilber
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity.
Biochimica et biophysica acta 2010;1801(1):49-57.
2009: Hiromi Hanaka; Sven-Christian Pawelzik; John Inge Johnsen; Marija Rakonjac Ryge; Kan Terawaki; Agnes Rasmuson; Baldur Sveinbjörnsson; Martin C Schumacher; Mats Hamberg; Bengt Samuelsson; Per-Johan Jakobsson; Per Kogner; Olof Rådmark
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(44):18757-62.
2009: Christian Feisst; Carlo Pergola; Marija Rakonjac Ryge; Antonietta Rossi; Andreas Koeberle; Gabriele Dodt; Marika Hoffmann; Christina Hoernig; Lutz Fischer; Dieter Steinhilber; Lutz Franke; Gisbert Schneider; Olof Rådmark; Lidia Sautebin; Oliver Werz
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.
Cellular and molecular life sciences : CMLS 2009;66(16):2759-71.
2009: Olof Rådmark; Bengt Samuelsson
5-Lipoxygenase: mechanisms of regulation.
Journal of lipid research 2009;50 Suppl():S40-5.
2009: Vildan Dincbas-Renqvist; Geneviève Pépin; Marija Rakonjac Ryge; Isabelle Plante; Dominique L Ouellet; Andreas Hermansson; Isabelle Goulet; Johanne Doucet; Bengt Samuelsson; Olof Rådmark; Patrick Provost
Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.
Biochimica et biophysica acta 2009;1789(2):99-108.
2009: Karina Roxana Gheorghe; Marina Korotkova; Anca Irinel Catrina; Linda Backman; Erik af Klint; Hans-Erik Claesson; Olof Rådmark; Per-Johan Jakobsson
Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.
Arthritis research & therapy 2009;11(3):R83.
2008: Alexander Seiler; Manuela Schneider; Heidi Förster; Stephan Roth; Eva K Wirth; Carsten Culmsee; Nikolaus Plesnila; Elisabeth Kremmer; Olof Rådmark; Wolfgang Wurst; Georg W Bornkamm; Ulrich Schweizer; Marcus Conrad
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.
Cell metabolism 2008;8(3):237-48.
2007: Nicole Schnur; Sabine Seuter; Careen Katryniok; Olof Rådmark; Dieter Steinhilber
The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes.
Biochimica et biophysica acta 2007;1771(10):1271-82.
2007: Olof Rådmark; Oliver Werz; Dieter Steinhilber; Bengt Samuelsson
5-Lipoxygenase: regulation of expression and enzyme activity.
Trends in biochemical sciences 2007;32(7):332-41.
2007: Sabine Seuter; Sami Väisänen; Olof Rådmark; Carsten Carlberg; Dieter Steinhilber
Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene.
Biochimica et biophysica acta 2007;1771(7):864-72.
2007: Olof Rådmark; Bengt Samuelsson
5-lipoxygenase: regulation and possible involvement in atherosclerosis.
Prostaglandins & other lipid mediators 2007;83(3):162-74.
2006: Marija Rakonjac Ryge; Lutz Fischer; Patrick Provost; Oliver Werz; Dieter Steinhilber; Bengt Samuelsson; Olof Rådmark
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):13150-5.
2006: Bernd L Sorg; Niko Klan; Sabine Seuter; David Dishart; Olof Rådmark; Andreas J R Habenicht; Carsten Carlberg; Oliver Werz; Dieter Steinhilber
Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site.
Biochimica et biophysica acta 2006;1761(7):686-97.
2006: Orison O Woolcott; Amanda Jabin Gustafsson; Mensur Dzabic; Cristina Pierro; Patrizia Tedeschi; Johanna Sandgren; M Rizuanul Bari; Hoa Nguyen; Marta Bianchi; Marija Rakonjac Ryge; Olof Rådmark; Claes-Göran Ostenson; Md Shahidul Islam
Arachidonic acid is a physiological activator of the ryanodine receptor in pancreatic beta-cells.
Cell calcium 2006;39(6):529-37.
2005: David Dishart; Nicole Schnur; Niko Klan; Oliver Werz; Dieter Steinhilber; Bengt Samuelsson; Olof Rådmark
GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site.
Biochimica et biophysica acta 2005;1738(1-3):37-47.
2005: Olof Rådmark; Bengt Samuelsson
Regulation of 5-lipoxygenase enzyme activity.
Biochemical and biophysical research communications 2005;338(1):102-10.
2005: Oliver Werz; Irina Tretiakova; Angela Michel; Annegret Ulke-Lemee; Michael Hörnig; Lutz Franke; Gisbert Schneider; Bengt Samuelsson; Olof Rådmark; Dieter Steinhilber
Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13164-9.
2005: Christina Hörnig; Dana Albert; Lutz Fischer; Michael Hörnig; Olof Rådmark; Dieter Steinhilber; Oliver Werz
1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain.
The Journal of biological chemistry 2005;280(29):26913-21.
2005: Hisayo Okamoto; Tove Hammarberg; Ying-Yi Zhang; Bengt Persson; Takashi Watanabe; Bengt Samuelsson; Olof Rådmark
Mutation analysis of the human 5-lipoxygenase C-terminus: support for a stabilizing C-terminal loop.
Biochimica et biophysica acta 2005;1749(1):123-31.
2005: Michiharu Tanabe; Hideki Kamitani; Takashi Watanabe; Olof Rådmark
C-terminus of p47(phox) is required for interaction with leukocyte type rat 12-lipoxygenase.
Protein and peptide letters 2005;12(3):295-7.
2005: Igor A Butovich; Mats Hamberg; Olof Rådmark
Novel oxylipins formed from docosahexaenoic acid by potato lipoxygenase--10(S)-hydroxydocosahexaenoic acid and 10,20-dihydroxydocosahexaenoic acid.
Lipids 2005;40(3):249-57.
2005: Michiharu Tanabe; Olof Rådmark; Takashi Watanabe; Akira Shiose; Hideki Sumimoto
Cloning of rat p47phox and comparison with human p47phox.
DNA sequence : the journal of DNA sequencing and mapping 2005;16(1):65-8.
2004: Edvards Liepinsh; Marija Rakonjac Ryge; Vincent Boissonneault; Patrick Provost; Bengt Samuelsson; Olof Rådmark; Gottfried Otting
NMR structure of human coactosin-like protein.
Journal of biomolecular NMR 2004;30(3):353-6.
2003: Eva Bürkert; Christina Arnold; Tove Hammarberg; Olof Rådmark; Dieter Steinhilber; Oliver Werz
The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1.
The Journal of biological chemistry 2003;278(44):42846-53.
2003: Yoontae Lee; Chiyoung Ahn; Jinju Han; Hyounjeong Choi; Jaekwang Kim; Jeongbin Yim; Junho Lee; Patrick Provost; Olof Rådmark; Sunyoung Kim; V Narry Kim
The nuclear RNase III Drosha initiates microRNA processing.
Nature 2003;425(6956):415-9.
2003: Olof Rådmark
5-lipoxygenase-derived leukotrienes: mediators also of atherosclerotic inflammation.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(7):1140-2.
2003: Lutz Fischer; Dagmar Szellas; Olof Rådmark; Dieter Steinhilber; Oliver Werz
Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(8):949-51.
2003: Hirschberg Daniel; Olof Rådmark; Hans Jörnvall; Tomas Bergman
Thr94 in bovine myelin basic protein is a second phosphorylation site for 42-kDa mitogen-activated protein kinase (ERK2).
Journal of protein chemistry 2003;22(2):177-81.
2003: Oliver Werz; Eva Bürkert; Lutz Fischer; Dagmar Szellas; David Dishart; Bengt Samuelsson; Olof Rådmark; Dieter Steinhilber
5-Lipoxygenase activation by MAPKAPK-2 and ERKs.
Advances in experimental medicine and biology 2003;525():129-32.
2003: Eva Bürkert; Dagmar Szellas; Olof Rådmark; Dieter Steinhilber; Oliver Werz
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid.
Journal of leukocyte biology 2003;73(1):191-200.
2002: Patrick Provost; David Dishart; Johanne Doucet; David Frendewey; Bengt Samuelsson; Olof Rådmark
Ribonuclease activity and RNA binding of recombinant human Dicer.
The EMBO journal 2002;21(21):5864-74.
2002: Oliver Werz; Eva Bürkert; Lutz Fischer; Dagmar Szellas; David Dishart; Bengt Samuelsson; Olof Rådmark; Dieter Steinhilber
Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(11):1441-3.
2002: Olof Rådmark
Arachidonate 5-lipoxygenase.
Prostaglandins & other lipid mediators 2002;68-69():211-34.
2002: Eva Bürkert; Olof Rådmark; Dieter Steinhilber; Oliver Werz
Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca2+-dependent.
Biochemical and biophysical research communications 2002;295(4):985-91.
2002: Oliver Werz; Dagmar Szellas; Dieter Steinhilber; Olof Rådmark
Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).
The Journal of biological chemistry 2002;277(17):14793-800.
2002: Eva Bürkert; Olof Rådmark; Bengt Samuelsson; Dieter Steinhilber; Oliver Werz
Hypertonicity suppresses ionophore-induced product formation and translocation of 5-lipoxygenase in human leukocytes.
Journal of leukocyte biology 2002;71(3):477-86.
2002: Oliver Werz; Eva Bürkert; Bengt Samuelsson; Olof Rådmark; Dieter Steinhilber
Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes.
Blood 2002;99(3):1044-52.
2002: Johanne Doucet; Patrick Provost; Bengt Samuelsson; Olof Rådmark
Molecular cloning and functional characterization of mouse coactosin-like protein.
Biochemical and biophysical research communications 2002;290(2):783-9.
2002: Tove Hammarberg; Konda Veera Reddy; Bengt Persson; Olof Rådmark
Calcium binding to 5-lipoxygenase.
Advances in experimental medicine and biology 2002;507():117-21.
2001: Oliver Werz; J Klemm; Olof Rådmark; Bengt Samuelsson
p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line.
Journal of leukocyte biology 2001;70(5):830-8.
2001: Patrick Provost; Johanne Doucet; A Stock; Günther Gerisch; Bengt Samuelsson; Olof Rådmark
Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75.
The Biochemical journal 2001;359(Pt 2):255-63.
2001: Tove Hammarberg; S Kuprin; Olof Rådmark; Arne Holmgren
EPR investigation of the active site of recombinant human 5-lipoxygenase: inhibition by selenide.
Biochemistry 2001;40(21):6371-8.
2001: Rainer Spanbroek; Markus Hildner; A Köhler; A Müller; F Zintl; H Kühn; Olof Rådmark; Bengt Samuelsson; Andreas J R Habenicht
IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5152-7.
2001: Oliver Werz; J Klemm; Bengt Samuelsson; Olof Rådmark
Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes.
Blood 2001;97(8):2487-95.
2000: Tove Hammarberg; Patrick Provost; Bengt Persson; Olof Rådmark
The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity.
The Journal of biological chemistry 2000;275(49):38787-93.
2000: Rainer Spanbroek; Markus Hildner; Dieter Steinhilber; Norbert E Fusenig; K Yoneda; Olof Rådmark; Bengt Samuelsson; Andreas J R Habenicht
5-lipoxygenase expression in dendritic cells generated from CD34(+) hematopoietic progenitors and in lymphoid organs.
Blood 2000;96(12):3857-65.
2000: Oliver Werz; J Klemm; Bengt Samuelsson; Olof Rådmark
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5261-6.
2000: K V Reddy; Tove Hammarberg; Olof Rådmark
Mg2+ activates 5-lipoxygenase in vitro: dependency on concentrations of phosphatidylcholine and arachidonic acid.
Biochemistry 2000;39(7):1840-8.
2000: Olof Rådmark
The molecular biology and regulation of 5-lipoxygenase.
American journal of respiratory and critical care medicine 2000;161(2 Pt 2):S11-5.
1999: Tove Hammarberg; Olof Rådmark
5-lipoxygenase binds calcium.
Biochemistry 1999;38(14):4441-7.
1999: Patrick Provost; Bengt Samuelsson; Olof Rådmark
Interaction of 5-lipoxygenase with cellular proteins.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):1881-5.
1999: D Härle; Olof Rådmark; Bengt Samuelsson; Dieter Steinhilber
Transcriptional and posttranscriptional regulation of 5-lipoxygenase mRNA expression in the human monocytic cell line Mono Mac 6 by transforming growth factor-beta and 1,25-dihydroxyvitamin D3.
Advances in experimental medicine and biology 1999;469():105-11.
1998: D Härle; Olof Rådmark; Bengt Samuelsson; Dieter Steinhilber
Calcitriol and transforming growth factor-beta upregulate 5-lipoxygenase mRNA expression by increasing gene transcription and mRNA maturation.
European journal of biochemistry / FEBS 1998;254(2):275-81.
1998: Pontus Forsell; Tove Hammarberg; T Johnsson; Jan Ake Lindgren; Olof Rådmark; Hans-Erik Claesson
Effects of 1-chloro-2,4,6-trinitrobenzene on 5-lipoxygenase activity and cellular leukotriene synthesis.
Biochemical pharmacology 1998;55(6):863-71.
1998: Rainer Spanbroek; H J Stark; U Janssen-Timmen; S Kraft; Markus Hildner; T Andl; F X Bosch; Norbert E Fusenig; T Bieber; Olof Rådmark; Bengt Samuelsson; Andreas J R Habenicht
5-Lipoxygenase expression in Langerhans cells of normal human epidermis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):663-8.
1995: Olof Rådmark
Arachidonate 5-lipoxygenase.
Journal of lipid mediators and cell signalling 1995;12(2-3):171-84.
1995: M Brungs; Olof Rådmark; Bengt Samuelsson; Dieter Steinhilber
Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1,25-dihydroxyvitamin D3.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(1):107-11.
1995: Dieter Steinhilber; M Brungs; Olof Rådmark; Bengt Samuelsson
Transforming growth factor-beta and 1,25-dihydroxyvitamin D3 induce 5-lipoxygenase activity during myeloid cell maturation.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():449-51.
1995: Olof Rådmark; Y Y Zhang; Tove Hammarberg; B Lind; Mats Hamberg; M Brungs; Dieter Steinhilber; Bengt Samuelsson
5-lipoxygenase: structure and stability of recombinant enzyme, regulation in Mono Mac 6 cells.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():1-9.
1994: M Brungs; Olof Rådmark; Bengt Samuelsson; Dieter Steinhilber
On the induction of 5-lipoxygenase expression and activity in HL-60 cells: effects of vitamin D3, retinoic acid, DMSO and TGF beta.
Biochemical and biophysical research communications 1994;205(3):1572-80.