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Christian Raetz

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Reynolds C Michael; Raetz Christian R H
Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars.
Bartling Craig M; Raetz Christian R H
Crystal structure and acyl chain selectivity of Escherichia coli LpxD, the N-acyltransferase of lipid A biosynthesis.
Garrett Teresa A; Raetz Christian R H; Richardson Travis; Kordestani Reza; Son Jennifer D; Rose Rebecca L
Identification of phosphatidylserylglutamate: a novel minor lipid in Escherichia coli.

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All Publications

2009: Reynolds C Michael; Raetz Christian R H
Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars.
Biochemistry 2009;48(40):9627-40.
2009: Bartling Craig M; Raetz Christian R H
Crystal structure and acyl chain selectivity of Escherichia coli LpxD, the N-acyltransferase of lipid A biosynthesis.
Biochemistry 2009;48(36):8672-83.
2009: Garrett Teresa A; Raetz Christian R H; Richardson Travis; Kordestani Reza; Son Jennifer D; Rose Rebecca L
Identification of phosphatidylserylglutamate: a novel minor lipid in Escherichia coli.
Journal of lipid research 2009;50(8):1589-99.
2009: Robins Lori I; Williams Allison H; Raetz Christian R H
Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA.
Biochemistry 2009;48(26):6191-201.
2009: Barb Adam W; Leavy Tanya M; Robins Lori I; Guan Ziqiang; Six David A; Zhou Pei; Hangauer Matthew J; Bertozzi Carolyn R; Raetz Christian R H
Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC.
Biochemistry 2009;48(14):3068-77.
2009: Fahy Eoin; Subramaniam Shankar; Murphy Robert C; Nishijima Masahiro; Raetz Christian R H; Shimizu Takao; Spener Friedrich; van Meer Gerrit; Wakelam Michael J O; Dennis Edward A
Update of the LIPID MAPS comprehensive classification system for lipids.
Journal of lipid research 2009;50 Suppl():S9-14.
2009: Raetz Christian R H; Guan Ziqiang; Ingram Brian O; Six David A; Song Feng; Wang Xiaoyuan; Zhao Jinshi
Discovery of new biosynthetic pathways: the lipid A story.
Journal of lipid research 2009;50 Suppl():S103-8.
2009: Rutten Lucy; Mannie Jean-Paul B A; Stead Christopher M; Raetz Christian R H; Reynolds C Michael; Bonvin Alexandre M J J; Tommassen Jan P; Egmond Maarten R; Trent M Stephen; Gros Piet
Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1960-4.
2009: Wang Xiaoyuan; Ribeiro Anthony A; Guan Ziqiang; Raetz Christian R H
Identification of undecaprenyl phosphate-beta-D-galactosamine in Francisella novicida and its function in lipid A modification.
Biochemistry 2009;48(6):1162-72.
2009: Song Feng; Guan Ziqiang; Raetz Christian R H
Biosynthesis of undecaprenyl phosphate-galactosamine and undecaprenyl phosphate-glucose in Francisella novicida.
Biochemistry 2009;48(6):1173-82.
2009: Karbarz Mark J; Six David A; Raetz Christian R H
Purification and characterization of the lipid A 1-phosphatase LpxE of Rhizobium leguminosarum.
The Journal of biological chemistry 2009;284(1):414-25.
2008: Ma Bing; Reynolds C Michael; Raetz Christian R H
Periplasmic orientation of nascent lipid A in the inner membrane of an Escherichia coli LptA mutant.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):13823-8.
2008: Six David A; Carty Sherry M; Guan Ziqiang; Raetz Christian R H
Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis.
Biochemistry 2008;47(33):8623-37.
2008: Grabinska Kariona A; Ghosh Sudip K; Guan Ziqiang; Cui Jike; Raetz Christian R H; Robbins Phillips W; Samuelson John
Dolichyl-phosphate-glucose is used to make O-glycans on glycoproteins of Trichomonas vaginalis.
Eukaryotic cell 2008;7(8):1344-51.
2008: Bartling Craig M; Raetz Christian R H
Steady-state kinetics and mechanism of LpxD, the N-acyltransferase of lipid A biosynthesis.
Biochemistry 2008;47(19):5290-302.
2008: Gibbons Henry S; Reynolds C Michael; Guan Ziqiang; Raetz Christian R H
An inner membrane dioxygenase that generates the 2-hydroxymyristate moiety of Salmonella lipid A.
Biochemistry 2008;47(9):2814-25.
2008: Schaaf Gabriel; Ortlund Eric A; Tyeryar Kimberly R; Mousley Carl J; Ile Kristina E; Garrett Teresa A; Ren Jihui; Woolls Melissa J; Raetz Christian R H; Redinbo Matthew R; Bankaitis Vytas A
Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily.
Molecular cell 2008;29(2):191-206.
2007: Guan Ziqiang; Li Shengrong; Smith Dale C; Shaw Walter A; Raetz Christian R H
Identification of N-acylphosphatidylserine molecules in eukaryotic cells.
Biochemistry 2007;46(50):14500-13.
2007: Yan Aixin; Guan Ziqiang; Raetz Christian R H
An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli.
The Journal of biological chemistry 2007;282(49):36077-89.
2007: Barb Adam W; Jiang Ling; Raetz Christian R H; Zhou Pei
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18433-8.
2007: Sohlenkamp Christian; Galindo-Lagunas Kanaan A; Guan Ziqiang; Vinuesa Pablo; Robinson Sally; Thomas-Oates Jane; Raetz Christian R H; Geiger Otto
The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions.
Molecular plant-microbe interactions : MPMI 2007;20(11):1421-30.
2007: Williams Allison H; Raetz Christian R H
Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13543-50.
2007: Ward Weslyn C; Guan Ziqiang; Zucca Fabio A; Fariello Ruggero G; Kordestani Reza; Zecca Luigi; Raetz Christian R H; Simon John D
Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain.
Journal of lipid research 2007;48(7):1457-62.
2007: Wang Xiaoyuan; Ribeiro Anthony A; Guan Ziqiang; Abraham Soman N; Raetz Christian R H
Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4136-41.
2007: Barb Adam W; McClerren Amanda L; Snehelatha Karnem; Reynolds C Michael; Zhou Pei; Raetz Christian R H
Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli.
Biochemistry 2007;46(12):3793-802.
2007: Sud Manish; Fahy Eoin; Cotter Dawn; Brown Alex; Dennis Edward A; Glass Christopher K; Merrill Alfred H; Murphy Robert C; Raetz Christian R H; Russell David W; Subramaniam Shankar
LMSD: LIPID MAPS structure database.
Nucleic acids research 2007;35(Database issue):D527-32.
2007: Garrett Teresa A; Kordestani Reza; Raetz Christian R H
Quantification of cardiolipin by liquid chromatography-electrospray ionization mass spectrometry.
Methods in enzymology 2007;433():213-30.
2007: Garrett Teresa A; Guan Ziqiang; Raetz Christian R H
Analysis of ubiquinones, dolichols, and dolichol diphosphate-oligosaccharides by liquid chromatography-electrospray ionization-mass spectrometry.
Methods in enzymology 2007;432():117-43.
2007: Raetz Christian R H; Reynolds C Michael; Trent M Stephen; Bishop Russell E
Lipid A modification systems in gram-negative bacteria.
Annual review of biochemistry 2007;76():295-329.
2006: Wang Xiaoyuan; Ribeiro Anthony A; Guan Ziqiang; McGrath Sara C; Cotter Robert J; Raetz Christian R H
Structure and biosynthesis of free lipid A molecules that replace lipopolysaccharide in Francisella tularensis subsp. novicida.
Biochemistry 2006;45(48):14427-40.
2006: Schaaf Gabriel; Betts Laurie; Garrett Teresa A; Raetz Christian R H; Bankaitis Vytas A
Crystallization and preliminary X-ray diffraction analysis of phospholipid-bound Sfh1p, a member of the Saccharomyces cerevisiae Sec14p-like phosphatidylinositol transfer protein family.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 11):1156-60.
2006: Reynolds C Michael; Ribeiro Anthony A; McGrath Sara C; Cotter Robert J; Raetz Christian R H; Trent M Stephen
An outer membrane enzyme encoded by Salmonella typhimurium lpxR that removes the 3'-acyloxyacyl moiety of lipid A.
The Journal of biological chemistry 2006;281(31):21974-87.
2006: Williams Allison H; Immormino Robert M; Gewirth Daniel T; Raetz Christian R H
Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10877-82.
2006: Mdluli Khisimuzi E; Witte Pamela R; Kline Toni; Barb Adam W; Erwin Alice L; Mansfield Bryce E; McClerren Amanda L; Pirrung Michael C; Tumey L Nathan; Warrener Paul; Raetz Christian R H; Stover C Kendall
Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy 2006;50(6):2178-84.
2006: Kanjilal-Kolar Suparna; Basu Shib Sankar; Kanipes Margaret I; Guan Ziqiang; Garrett Teresa A; Raetz Christian R H
Expression cloning of three Rhizobium leguminosarum lipopolysaccharide core galacturonosyltransferases.
The Journal of biological chemistry 2006;281(18):12865-78.
2006: Kanjilal-Kolar Suparna; Raetz Christian R H
Dodecaprenyl phosphate-galacturonic acid as a donor substrate for lipopolysaccharide core glycosylation in Rhizobium leguminosarum.
The Journal of biological chemistry 2006;281(18):12879-87.
2006: Raetz Christian R H; Garrett Teresa A; Reynolds C Michael; Shaw Walter A; Moore Jeff D; Smith Dale C; Ribeiro Anthony A; Murphy Robert C; Ulevitch Richard J; Fearns Colleen; Reichart Donna; Glass Christopher K; Benner Chris; Subramaniam Shankar; Harkewicz Richard; Bowers-Gentry Rebecca C; Buczynski Matthew W; Cooper Jennifer A; Deems Raymond A; Dennis Edward A
Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4.
Journal of lipid research 2006;47(5):1097-111.
2006: Wang Xiaoyuan; McGrath Sara C; Cotter Robert J; Raetz Christian R H
Expression cloning and periplasmic orientation of the Francisella novicida lipid A 4'-phosphatase LpxF.
The Journal of biological chemistry 2006;281(14):9321-30.
2005: McClerren Amanda L; Endsley Stephanie; Bowman Jason L; Andersen Niels H; Guan Ziqiang; Rudolph Johannes; Raetz Christian R H
A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin.
Biochemistry 2005;44(50):16574-83.
2005: Nahori Marie-Anne; Fournié-Amazouz Edith; Que-Gewirth Nanette S; Balloy Viviane; Chignard Michel; Raetz Christian R H; Saint Girons Isabelle; Werts Catherine
Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):6022-31.
2005: Guan Ziqiang; Breazeale Steven D; Raetz Christian R H
Extraction and identification by mass spectrometry of undecaprenyl diphosphate-MurNAc-pentapeptide-GlcNAc from Escherichia coli.
Analytical biochemistry 2005;345(2):336-9.
2005: Boon Hinckley Middleton; Reynolds C Michael; Ribeiro Anthony A; McGrath Sara C; Cotter Robert J; Lauw Fanny N; Golenbock Douglas T; Raetz Christian R H
A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A.
The Journal of biological chemistry 2005;280(34):30214-24.
2005: Tran An X; Lester Melissa E; Stead Christopher M; Raetz Christian R H; Maskell Duncan J; McGrath Sara C; Cotter Robert J; Trent M Stephen
Resistance to the antimicrobial peptide polymyxin requires myristoylation of Escherichia coli and Salmonella typhimurium lipid A.
The Journal of biological chemistry 2005;280(31):28186-94.
2005: Doerrler William T; Raetz Christian R H
Loss of outer membrane proteins without inhibition of lipid export in an Escherichia coli YaeT mutant.
The Journal of biological chemistry 2005;280(30):27679-87.
2005: Williams Gareth J; Breazeale Steven D; Raetz Christian R H; Naismith James H
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
The Journal of biological chemistry 2005;280(24):23000-8.
2005: Reynolds C Michael; Kalb Suzanne R; Cotter Robert J; Raetz Christian R H
A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant.
The Journal of biological chemistry 2005;280(22):21202-11.
2005: Fahy Eoin; Subramaniam Shankar; Brown H Alex; Glass Christopher K; Merrill Alfred H; Murphy Robert C; Raetz Christian R H; Russell David W; Seyama Yousuke; Shaw Walter; Shimizu Takao; Spener Friedrich; van Meer Gerrit; VanNieuwenhze Michael S; White Stephen H; Witztum Joseph L; Dennis Edward A
A comprehensive classification system for lipids.
Journal of lipid research 2005;46(5):839-61.
2005: Ortlund Eric A; Lee Yoonkwang; Solomon Isaac H; Hager Janet M; Safi Rachid; Choi Yunhee; Guan Ziqiang; Tripathy Ashutosh; Raetz Christian R H; McDonnell Donald P; Moore David D; Redinbo Matthew R
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.
Nature structural & molecular biology 2005;12(4):357-63.
2005: Breazeale Steven D; Ribeiro Anthony A; McClerren Amanda L; Raetz Christian R H
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
The Journal of biological chemistry 2005;280(14):14154-67.
2005: Coggins Brian E; McClerren Amanda L; Jiang Ling; Li Xuechen; Rudolph Johannes; Hindsgaul Ole; Raetz Christian R H; Zhou Pei
Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.
Biochemistry 2005;44(4):1114-26.
2005: McClerren Amanda L; Zhou Pei; Guan Ziqiang; Raetz Christian R H; Rudolph Johannes
Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.
Biochemistry 2005;44(4):1106-13.
2005: Gibbons Henry S; Kalb Suzanne R; Cotter Robert J; Raetz Christian R H
Role of Mg2+ and pH in the modification of Salmonella lipid A after endocytosis by macrophage tumour cells.
Molecular microbiology 2005;55(2):425-40.
2004: Tran An X; Karbarz Mark J; Wang Xiaoyuan; Raetz Christian R H; McGrath Sara C; Cotter Robert J; Trent M Stephen
Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A.
The Journal of biological chemistry 2004;279(53):55780-91.
2004: Jain Nitin U; Wyckoff Timna J O; Raetz Christian R H; Prestegard James H
Rapid analysis of large protein-protein complexes using NMR-derived orientational constraints: the 95 kDa complex of LpxA with acyl carrier protein.
Journal of molecular biology 2004;343(5):1379-89.
2004: Wang Xiaoyuan; Karbarz Mark J; McGrath Sara C; Cotter Robert J; Raetz Christian R H
MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of francisella novicida LpxE expressed in Escherichia coli.
The Journal of biological chemistry 2004;279(47):49470-8.
2004: Doerrler William T; Gibbons Henry S; Raetz Christian R H
MsbA-dependent translocation of lipids across the inner membrane of Escherichia coli.
The Journal of biological chemistry 2004;279(43):45102-9.
2004: Sweet Charles R; Ribeiro Anthony A; Raetz Christian R H
Oxidation and transamination of the 3"-position of UDP-N-acetylglucosamine by enzymes from Acidithiobacillus ferrooxidans. Role in the formation of lipid a molecules with four amide-linked acyl chains.
The Journal of biological chemistry 2004;279(24):25400-10.
2004: Sweet Charles R; Williams Allison H; Karbarz Mark J; Werts Catherine; Kalb Suzanne R; Cotter Robert J; Raetz Christian R H
Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group.
The Journal of biological chemistry 2004;279(24):25411-9.
2004: Que-Gewirth Nanette L S; Ribeiro Anthony A; Kalb Suzanne R; Cotter Robert J; Bulach Dieter M; Adler Ben; Girons Isabelle Saint; Werts Catherine; Raetz Christian R H
A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2.
The Journal of biological chemistry 2004;279(24):25420-9.
2004: Coggins Brian E; Li Xuechen; Hindsgaul Ole; Raetz Christian R H; Zhou Pei
Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514.
Journal of biomolecular NMR 2004;28(2):201-2.
2003: Karbarz Mark J; Kalb Suzanne R; Cotter Robert J; Raetz Christian R H
Expression cloning and biochemical characterization of a Rhizobium leguminosarum lipid A 1-phosphatase.
The Journal of biological chemistry 2003;278(41):39269-79.
2003: Coggins Brian E; Li Xuechen; McClerren Amanda L; Hindsgaul Ole; Raetz Christian R H; Zhou Pei
Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.
Nature structural biology 2003;10(8):645-51.
2003: Breazeale Steven D; Ribeiro Anthony A; Raetz Christian R H
Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose.
The Journal of biological chemistry 2003;278(27):24731-9.
2003: Kanipes Margaret I; Ribeiro Anthony A; Lin Shanhua; Cotter Robert J; Raetz Christian R H
A mannosyl transferase required for lipopolysaccharide inner core assembly in Rhizobium leguminosarum. Purification, substrate specificity, and expression in Salmonella waaC mutants.
The Journal of biological chemistry 2003;278(18):16356-64.
2003: Kanipes Margaret I; Kalb Suzanne R; Cotter Robert J; Hozbor Daniela F; Lagares Antonio; Raetz Christian R H
Relaxed sugar donor selectivity of a Sinorhizobium meliloti ortholog of the Rhizobium leguminosarum mannosyl transferase LpcC. Role of the lipopolysaccharide core in symbiosis of Rhizobiaceae with plants.
The Journal of biological chemistry 2003;278(18):16365-71.
2003: Que-Gewirth Nanette L S; Karbarz Mark J; Kalb Suzanne R; Cotter Robert J; Raetz Christian R H
Origin of the 2-amino-2-deoxy-gluconate unit in Rhizobium leguminosarum lipid A. Expression cloning of the outer membrane oxidase LpxQ.
The Journal of biological chemistry 2003;278(14):12120-9.
2003: Que-Gewirth Nanette L S; Lin Shanhua; Cotter Robert J; Raetz Christian R H
An outer membrane enzyme that generates the 2-amino-2-deoxy-gluconate moiety of Rhizobium leguminosarum lipid A.
The Journal of biological chemistry 2003;278(14):12109-19.
2003: Li Xuechen; Uchiyama Taketo; Raetz Christian R H; Hindsgaul Ole
Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis.
Organic letters 2003;5(4):539-41.
2003: Pirrung Michael C; Tumey L Nathan; McClerren Amanda L; Raetz Christian R H
High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: in vitro enzyme inhibition and antibacterial properties.
Journal of the American Chemical Society 2003;125(6):1575-86.
2002: Hwang Peter M; Choy Wing-Yiu; Lo Eileen I; Chen Lu; Forman-Kay Julie D; Raetz Christian R H; Privé Gilbert G; Bishop Russell E; Kay Lewis E
Solution structure and dynamics of the outer membrane enzyme PagP by NMR.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13560-5.
2002: Pirrung Michael C; Tumey L Nathan; Raetz Christian R H; Jackman Jane E; Snehalatha Karnem; McClerren Amanda L; Fierke Carol A; Gantt Stephanie L; Rusche Kristin M
Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups.
Journal of medicinal chemistry 2002;45(19):4359-70.
2002: Doerrler William T; Raetz Christian R H
ATPase activity of the MsbA lipid flippase of Escherichia coli.
The Journal of biological chemistry 2002;277(39):36697-705.
2002: Basu Shib Sankar; Karbarz Mark J; Raetz Christian R H
Expression cloning and characterization of the C28 acyltransferase of lipid A biosynthesis in Rhizobium leguminosarum.
The Journal of biological chemistry 2002;277(32):28959-71.
2002: Kline Toni; Andersen Niels H; Harwood Eric A; Bowman Jason; Malanda Andre; Endsley Stephanie; Erwin Alice L; Doyle Michael; Fong Susan; Harris Alex L; Mendelsohn Brian; Mdluli Khisimuzi; Raetz Christian R H; Stover C Kendall; Witte Pamela R; Yabannavar Asha; Zhu Shuguang
Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC.
Journal of medicinal chemistry 2002;45(14):3112-29.
2002: Babinski Kristen J; Kanjilal Suparna J; Raetz Christian R H
Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene.
The Journal of biological chemistry 2002;277(29):25947-56.
2002: Babinski Kristen J; Ribeiro Anthony A; Raetz Christian R H
The Escherichia coli gene encoding the UDP-2,3-diacylglucosamine pyrophosphatase of lipid A biosynthesis.
The Journal of biological chemistry 2002;277(29):25937-46.
2002: Sweet Charles R; Preston Andrew; Toland Elinor; Ramirez Suzanne M; Cotter Robert J; Maskell Duncan J; Raetz Christian R H
Relaxed acyl chain specificity of Bordetella UDP-N-acetylglucosamine acyltransferases.
The Journal of biological chemistry 2002;277(21):18281-90.
2002: Raetz Christian R H
Remembering Konrad Bloch.
Biochemical and biophysical research communications 2002;292(5):1167-70.
2002: Vorachek-Warren Mara K; Ramirez Suzanne; Cotter Robert J; Raetz Christian R H
A triple mutant of Escherichia coli lacking secondary acyl chains on lipid A.
The Journal of biological chemistry 2002;277(16):14194-205.
2002: Vorachek-Warren Mara K; Carty Sherry M; Lin Shanhua; Cotter Robert J; Raetz Christian R H
An Escherichia coli mutant lacking the cold shock-induced palmitoleoyltransferase of lipid A biosynthesis: absence of unsaturated acyl chains and antibiotic hypersensitivity at 12 degrees C.
The Journal of biological chemistry 2002;277(16):14186-93.
2002: Breazeale Steven D; Ribeiro Anthony A; Raetz Christian R H
Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose.
The Journal of biological chemistry 2002;277(4):2886-96.
2002: Raetz Christian R H; Whitfield Chris
Lipopolysaccharide endotoxins.
Annual review of biochemistry 2002;71():635-700.
2001: Trent M S; Ribeiro A A; Doerrler W T; Lin S; Cotter R J; Raetz C R
Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm.
The Journal of biological chemistry 2001;276(46):43132-44.
2001: Trent M S; Ribeiro A A; Lin S; Cotter R J; Raetz C R
An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor.
The Journal of biological chemistry 2001;276(46):43122-31.
2001: Zhou Z; Ribeiro A A; Lin S; Cotter R J; Miller S I; Raetz C R
Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PMRA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation.
The Journal of biological chemistry 2001;276(46):43111-21.
2001: Sweet C R; Lin S; Cotter R J; Raetz C R
A Chlamydia trachomatis UDP-N-acetylglucosamine acyltransferase selective for myristoyl-acyl carrier protein. Expression in Escherichia coli and formation of hybrid lipid A species.
The Journal of biological chemistry 2001;276(22):19565-74.
2001: Doerrler W T; Reedy M C; Raetz C R
An Escherichia coli mutant defective in lipid export.
The Journal of biological chemistry 2001;276(15):11461-4.
2001: Trent M S; Pabich W; Raetz C R; Miller S I
A PhoP/PhoQ-induced Lipase (PagL) that catalyzes 3-O-deacylation of lipid A precursors in membranes of Salmonella typhimurium.
The Journal of biological chemistry 2001;276(12):9083-92.
2001: Jackman J E; Raetz C R; Fierke C A
Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site.
Biochemistry 2001;40(2):514-23.
2001: Kanipes M I; Lin S; Cotter R J; Raetz C R
Ca2+-induced phosphoethanolamine transfer to the outer 3-deoxy-D-manno-octulosonic acid moiety of Escherichia coli lipopolysaccharide. A novel membrane enzyme dependent upon phosphatidylethanolamine.
The Journal of biological chemistry 2001;276(2):1156-63.
2001: Raetz C R
Regulated covalent modifications of lipid A.
Journal of endotoxin research 2001;7(1):73-8.
2000: Bishop R E; Gibbons H S; Guina T; Trent M S; Miller S I; Raetz C R
Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria.
The EMBO journal 2000;19(19):5071-80.
2000: Gibbons H S; Lin S; Cotter R J; Raetz C R
Oxygen requirement for the biosynthesis of the S-2-hydroxymyristate moiety in Salmonella typhimurium lipid A. Function of LpxO, A new Fe2+/alpha-ketoglutarate-dependent dioxygenase homologue.
The Journal of biological chemistry 2000;275(42):32940-9.
2000: Que N L; Ribeiro A A; Raetz C R
Two-dimensional NMR spectroscopy and structures of six lipid A species from Rhizobium etli CE3. Detection of an acyloxyacyl residue in each component and origin of the aminogluconate moiety.
The Journal of biological chemistry 2000;275(36):28017-27.
2000: Que N L; Lin S; Cotter R J; Raetz C R
Purification and mass spectrometry of six lipid A species from the bacterial endosymbiont Rhizobium etli. Demonstration of a conserved distal unit and a variable proximal portion.
The Journal of biological chemistry 2000;275(36):28006-16.
2000: Zhou Z; Ribeiro A A; Raetz C R
High-resolution NMR spectroscopy of lipid A molecules containing 4-amino-4-deoxy-L-arabinose and phosphoethanolamine substituents. Different attachment sites on lipid A molecules from NH4VO3-treated Escherichia coli versus kdsA mutants of Salmonella typhimurium.
The Journal of biological chemistry 2000;275(18):13542-51.
2000: Basu S S; Dotson G D; Raetz C R
A facile enzymatic synthesis of uridine diphospho-[14C]galacturonic acid.
Analytical biochemistry 2000;280(1):173-7.
2000: Jackman J E; Fierke C A; Tumey L N; Pirrung M; Uchiyama T; Tahir S H; Hindsgaul O; Raetz C R
Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs.
The Journal of biological chemistry 2000;275(15):11002-9.
1999: White K A; Lin S; Cotter R J; Raetz C R
A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence.
The Journal of biological chemistry 1999;274(44):31391-400.
1999: Wyckoff T J; Raetz C R
The active site of Escherichia coli UDP-N-acetylglucosamine acyltransferase. Chemical modification and site-directed mutagenesis.
The Journal of biological chemistry 1999;274(38):27047-55.
1999: Zhou Z; Lin S; Cotter R J; Raetz C R
Lipid A modifications characteristic of Salmonella typhimurium are induced by NH4VO3 in Escherichia coli K12. Detection of 4-amino-4-deoxy-L-arabinose, phosphoethanolamine and palmitate.
The Journal of biological chemistry 1999;274(26):18503-14.
1999: Basu S S; White K A; Que N L; Raetz C R
A deacylase in Rhizobium leguminosarum membranes that cleaves the 3-O-linked beta-hydroxymyristoyl moiety of lipid A precursors.
The Journal of biological chemistry 1999;274(16):11150-8.
1999: Basu S S; York J D; Raetz C R
A phosphotransferase that generates phosphatidylinositol 4-phosphate (PtdIns-4-P) from phosphatidylinositol and lipid A in Rhizobium leguminosarum. A membrane-bound enzyme linking lipid a and ptdins-4-p biosynthesis.
The Journal of biological chemistry 1999;274(16):11139-49.
1999: Carty S M; Sreekumar K R; Raetz C R
Effect of cold shock on lipid A biosynthesis in Escherichia coli. Induction At 12 degrees C of an acyltransferase specific for palmitoleoyl-acyl carrier protein.
The Journal of biological chemistry 1999;274(14):9677-85.
1999: Garrett T A; Rosser M F; Raetz C R
Signal transduction triggered by lipid A-like molecules in 70Z/3 pre-B lymphocyte tumor cells.
Biochimica et biophysica acta 1999;1437(2):246-56.
1999: Jackman J E; Raetz C R; Fierke C A
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme.
Biochemistry 1999;38(6):1902-11.
1998: Wyckoff T J; Lin S; Cotter R J; Dotson G D; Raetz C R
Hydrocarbon rulers in UDP-N-acetylglucosamine acyltransferases.
The Journal of biological chemistry 1998;273(49):32369-72.
1998: Kadrmas J L; Allaway D; Studholme R E; Sullivan J T; Ronson C W; Poole P S; Raetz C R
Cloning and overexpression of glycosyltransferases that generate the lipopolysaccharide core of Rhizobium leguminosarum.
The Journal of biological chemistry 1998;273(41):26432-40.
1998: Zhou Z; White K A; Polissi A; Georgopoulos C; Raetz C R
Function of Escherichia coli MsbA, an essential ABC family transporter, in lipid A and phospholipid biosynthesis.
The Journal of biological chemistry 1998;273(20):12466-75.
1998: Garrett T A; Que N L; Raetz C R
Accumulation of a lipid A precursor lacking the 4'-phosphate following inactivation of the Escherichia coli lpxK gene.
The Journal of biological chemistry 1998;273(20):12457-65.
1998: Wyckoff T J; Raetz C R; Jackman J E
Antibacterial and anti-inflammatory agents that target endotoxin.
Trends in microbiology 1998;6(4):154-9.
1998: Kadrmas J L; Raetz C R
Enzymatic synthesis of lipopolysaccharide in Escherichia coli. Purification and properties of heptosyltransferase i.
The Journal of biological chemistry 1998;273(5):2799-807.
1998: Dotson G D; Kaltashov I A; Cotter R J; Raetz C R
Expression cloning of a Pseudomonas gene encoding a hydroxydecanoyl-acyl carrier protein-dependent UDP-GlcNAc acyltransferase.
Journal of bacteriology 1998;180(2):330-7.
1998: Raetz C R
Enzymes of lipid A biosynthesis: targets for the design of new antibiotics.
Progress in clinical and biological research 1998;397():1-14.
1997: Garrett T A; Kadrmas J L; Raetz C R
Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK.
The Journal of biological chemistry 1997;272(35):21855-64.
1997: Odegaard T J; Kaltashov I A; Cotter R J; Steeghs L; van der Ley P; Khan S; Maskell D J; Raetz C R
Shortened hydroxyacyl chains on lipid A of Escherichia coli cells expressing a foreign UDP-N-acetylglucosamine O-acyltransferase.
The Journal of biological chemistry 1997;272(32):19688-96.
1997: White K A; Kaltashov I A; Cotter R J; Raetz C R
A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae.
The Journal of biological chemistry 1997;272(26):16555-63.
1997: Clementz T; Zhou Z; Raetz C R
Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. Acylation by MsbB follows laurate incorporation by HtrB.
The Journal of biological chemistry 1997;272(16):10353-60.
1996: Milla M E; Raetz C R
Association of lipid A disaccharide synthase with aerobic glycerol-3-phosphate dehydrogenase in extracts of Escherichia coli.
Biochimica et biophysica acta 1996;1304(3):245-53.
1996: Brozek K A; Carlson R W; Raetz C R
A special acyl carrier protein for transferring long hydroxylated fatty acids to lipid A in Rhizobium.
The Journal of biological chemistry 1996;271(50):32126-36.
1996: Kadrmas J L; Brozek K A; Raetz C R
Lipopolysaccharide core glycosylation in Rhizobium leguminosarum. An unusual mannosyl transferase resembling the heptosyl transferase I of Escherichia coli.
The Journal of biological chemistry 1996;271(50):32119-25.
1996: Brozek K A; Kadrmas J L; Raetz C R
Lipopolysaccharide biosynthesis in Rhizobium leguminosarum. Novel enzymes that process precursors containing 3-deoxy-D-manno-octulosonic acid.
The Journal of biological chemistry 1996;271(50):32112-8.
1996: Onishi H R; Pelak B A; Gerckens L S; Silver L L; Kahan F M; Chen M H; Patchett A A; Galloway S M; Hyland S A; Anderson M S; Raetz C R
Antibacterial agents that inhibit lipid A biosynthesis.
Science (New York, N.Y.) 1996;274(5289):980-2.
1996: Sorensen P G; Lutkenhaus J; Young K; Eveland S S; Anderson M S; Raetz C R
Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymatic step of lipid a biosynthesis.
The Journal of biological chemistry 1996;271(42):25898-905.
1996: Clementz T; Bednarski J J; Raetz C R
Function of the htrB high temperature requirement gene of Escherchia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate.
The Journal of biological chemistry 1996;271(20):12095-102.
1995: Young K; Silver L L; Bramhill D; Cameron P; Eveland S S; Raetz C R; Hyland S A; Anderson M S
The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase.
The Journal of biological chemistry 1995;270(51):30384-91.
1995: Belunis C J; Clementz T; Carty S M; Raetz C R
Inhibition of lipopolysaccharide biosynthesis and cell growth following inactivation of the kdtA gene in Escherichia coli.
The Journal of biological chemistry 1995;270(46):27646-52.
1995: Raetz C R; Roderick S L
A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase.
Science (New York, N.Y.) 1995;270(5238):997-1000.
1995: Price N P; Jeyaretnam B; Carlson R W; Kadrmas J L; Raetz C R; Brozek K A
Lipid A biosynthesis in Rhizobium leguminosarum: role of a 2-keto-3-deoxyoctulosonate-activated 4' phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7352-6.
1995: Carlson R W; Forsberg L S; Price N P; Bhat U R; Kelly T M; Raetz C R
The structure and biosynthesis of Rhizobium leguminosarum lipid A.
Progress in clinical and biological research 1995;392():25-31.
1994: Mohan S; Kelly T M; Eveland S S; Raetz C R; Anderson M S
An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis.
The Journal of biological chemistry 1994;269(52):32896-903.
1994: Mohan S; Raetz C R
Endotoxin biosynthesis in Pseudomonas aeruginosa: enzymatic incorporation of laurate before 3-deoxy-D-manno-octulosonate.
Journal of bacteriology 1994;176(22):6944-51.
1994: Price N P; Kelly T M; Raetz C R; Carlson R W
Biosynthesis of a structurally novel lipid A in Rhizobium leguminosarum: identification and characterization of six metabolic steps leading from UDP-GlcNAc to 3-deoxy-D-manno-2-octulosonic acid2-lipid IVA.
Journal of bacteriology 1994;176(15):4646-55.
1993: Raetz C R
Bacterial endotoxins: extraordinary lipids that activate eucaryotic signal transduction.
Journal of bacteriology 1993;175(18):5745-53.
1993: Kelly T M; Stachula S A; Raetz C R; Anderson M S
The firA gene of Escherichia coli encodes UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase. The third step of endotoxin biosynthesis.
The Journal of biological chemistry 1993;268(26):19866-74.
1993: Anderson M S; Bull H G; Galloway S M; Kelly T M; Mohan S; Radika K; Raetz C R
UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorable.
The Journal of biological chemistry 1993;268(26):19858-65.
1992: Belunis C J; Mdluli K E; Raetz C R; Nano F E
A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope.
The Journal of biological chemistry 1992;267(26):18702-7.

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