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Sima Rafati

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Noushin Saljoughian; Tahere Taheri; Yasaman Taslimi; Mohammad Vasei; Farnaz Zahedifard; Hiva Azizi; Azam Bolhassani; delaram doroud; Fatemeh Doustdari; Kazem Heidari; Nabiollah Namvar Asl; Barbara Papadopoulou; Sima Rafati
Development of Novel Prime-Boost Strategies Based on a Tri-Gene Fusion Recombinant L. tarentolae Vaccine against Experimental Murine Visceral Leishmaniasis.
Azam Bolhassani; Sima Rafati
Mini-chaperones: potential immuno-stimulators in vaccine design.
Elham Mohit; Azam Bolhassani; Ali Eslamifar; Katayoun Samimi-Rad; Negar Seyed; Mohammad Taghikhani; Farnaz Zahedifard; Sima Rafati
Immunomodulatory effects of IP-10 chemokine along with PEI600-Tat delivery system in DNA vaccination against HPV infections.

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All Publications

2013: Noushin Saljoughian; Tahere Taheri; Yasaman Taslimi; Mohammad Vasei; Farnaz Zahedifard; Hiva Azizi; Azam Bolhassani; delaram doroud; Fatemeh Doustdari; Kazem Heidari; Nabiollah Namvar Asl; Barbara Papadopoulou; Sima Rafati
Development of Novel Prime-Boost Strategies Based on a Tri-Gene Fusion Recombinant L. tarentolae Vaccine against Experimental Murine Visceral Leishmaniasis.
PLoS neglected tropical diseases 2013;7(4):e2174.
2013: Azam Bolhassani; Sima Rafati
Mini-chaperones: potential immuno-stimulators in vaccine design.
Human vaccines & immunotherapeutics 2013;9(1):153-61.
2013: Elham Mohit; Azam Bolhassani; Ali Eslamifar; Katayoun Samimi-Rad; Negar Seyed; Mohammad Taghikhani; Farnaz Zahedifard; Sima Rafati
Immunomodulatory effects of IP-10 chemokine along with PEI600-Tat delivery system in DNA vaccination against HPV infections.
Molecular immunology 2013;53(1-2):149-60.
2012: Amin Daemi; Sahar Hosseinzadeh; Sima Rafati; Farnaz Zahedifard; Azam Bolhassani; Fatemeh Doustdari
Different domains of glycoprotein 96 influence HPV16 E7 DNA vaccine potency via electroporation mediated delivery in tumor mice model.
Immunology letters 2012;148(2):117-25.
2012: Maryam Salehi; Mandana Sattari; Negar Seyed; Tahereh Taheri; Yasaman Taslimi; Farnaz Zahedifard; Azam Bolhassani; Elham Mohit; Sima Rafati
Recombinant Leishmania tarentolae encoding the HPV type 16 E7 gene in tumor mice model.
Immunotherapy 2012;4(11):1107-20.
2012: Elham Mohit; Sima Rafati
Chemokine-based immunotherapy: delivery systems and combination therapies.
Immunotherapy 2012;4(8):807-40.
2011: Akram Abouie Mehrizi; Sima Rafati; Ali Hatef Salmanian; Sedigheh Zakeri; Navid Dinparast Djadid
Immune responses elicited by co-immunization of Plasmodium vivax and P. falciparum MSP-1 using prime-boost immunization strategies.
Parasite immunology 2011;33(11):594-608.
2011: S Safaiyan; Hannah Akuffo; A Bolhassani; S Nylen; Sima Rafati
Contribution of human neutrophils in the development of protective immune response during in vitro Leishmania major infection.
Parasite immunology 2011;33(11):609-20.
2011: Negar Seyed; Iraj Sharifi; Farnaz Zahedifard; Nasir Saeedi Eslami; Shima Safaiyan; Kayhan Azadmanesh; Fatemeh Doustdari; Ali Eslami Far; Elham Gholami; Akbar Khadem Sadegh; Maryam Mirzaei; Sima Rafati
In silico analysis of six known Leishmania major antigens and in vitro evaluation of specific epitopes eliciting HLA-A2 restricted CD8 T cell response.
PLoS neglected tropical diseases 2011;5(9):e1295.
2011: Amir Mizbani; Tahere Taheri; Yasaman Taslimi; Farnaz Zahedifard; Sima Rafati
Effect of A2 gene on infectivity of the nonpathogenic parasite Leishmania tarentolae.
Parasitology research 2011;109(3):793-9.
2011: delaram doroud; Abdolhossein Rouholamini Najafabadi; Yasaman Taslimi; Fatemeh Torkashvand; Rouholah Vahabpour; Alireza Vatanara; Behrooz Vaziri; Farnaz Zahedifard; Sima Rafati
Delivery of a cocktail DNA vaccine encoding cysteine proteinases type I, II and III with solid lipid nanoparticles potentiate protective immunity against Leishmania major infection.
Journal of controlled release : official journal of the Controlled Release Society 2011;153(2):154-62.
2011: Mary Ann McDowell; Sima Rafati; Marcelo Ramalho-Ortigao; Afif Ben Salah
Leishmaniasis: Middle East and North Africa research and development priorities.
PLoS neglected tropical diseases 2011;5(7):e1219.
2011: delaram doroud; Abdolhossein Rouholamini Najafabadi; Yasaman Taslimi; Fatemeh Torkashvand; Rouholah Vahabpour; Alireza Vatanara; Behrooz Vaziri; Farnaz Zahedifard; Sima Rafati
C-terminal domain deletion enhances the protective activity of cpa/cpb loaded solid lipid nanoparticles against Leishmania major in BALB/c mice.
PLoS neglected tropical diseases 2011;5(7):e1236.
2011: delaram doroud; Farnaz Zahedifard; A Vatanara; Abdolhossein Rouholamini Najafabadi; Sima Rafati
Cysteine proteinase type I, encapsulated in solid lipid nanoparticles induces substantial protection against Leishmania major infection in C57BL/6 mice.
Parasite immunology 2011;33(6):335-48.
2011: Azam Bolhassani; Elham Gholami; Farnaz Zahedifard; Neda Moradin; Parto Parsi; Fatemeh Doustdari; Negar Seyed; Barbara Papadopoulou; Sima Rafati
Leishmania major: Protective capacity of DNA vaccine using amastin fused to HSV-1 VP22 and EGFP in BALB/c mice model.
Experimental parasitology 2011;128(1):9-17.
2011: Jafar Amani; Seyed Latif Mousavi; Sima Rafati; Ali Hatef Salmanian
Immunogenicity of a plant-derived edible chimeric EspA, Intimin and Tir of Escherichia coli O157:H7 in mice.
Plant science : an international journal of experimental plant biology 2011;180(4):620-7.
2011: Narges Abdian; Elham Gholami; Farnaz Zahedifard; Nozhat Safaee; Sima Rafati
Evaluation of DNA/DNA and prime-boost vaccination using LPG3 against Leishmania major infection in susceptible BALB/c mice and its antigenic properties in human leishmaniasis.
Experimental parasitology 2011;127(3):627-36.
2011: Azam Bolhassani; Tahere Taheri; Yasaman Taslimi; Soheila Zamanilui; Farnaz Zahedifard; Negar Seyed; Fatemeh Torkashvand; Behrouz Vaziri; Sima Rafati
Fluorescent Leishmania species: development of stable GFP expression and its application for in vitro and in vivo studies.
Experimental parasitology 2011;127(3):637-45.
2011: Azam Bolhassani; Shima Safaiyan; Sima Rafati
Improvement of different vaccine delivery systems for cancer therapy.
Molecular cancer 2011;10():3.
2010: delaram doroud; Alireza Vatanara; Farnaz Zahedifard; Elham Gholami; Rouhollah Vahabpour; Abdolhossein Rouholamini Najafabadi; Sima Rafati
Cationic solid lipid nanoparticles loaded by cystein proteinase genes as a novel anti-leishmaniasis DNA vaccine delivery system: characterization and in vitro evaluations.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):e105-6.
2010: Jafar Amani; Ali Hatef Salmanian; Sima Rafati; Seyed Latif Mousavi
Immunogenic properties of chimeric protein from espA, eae and tir genes of Escherichia coli O157:H7.
Vaccine 2010;28(42):6923-9.
2010: Tahere Taheri; Ali Hatef Salmanian; Elham Gholami; Fatemeh Doustdari; Farnaz Zahedifard; Sima Rafati
Leishmania major: disruption of signal peptidase type I and its consequences on survival, growth and infectivity.
Experimental parasitology 2010;126(2):135-45.
2010: Arash Arashkia; Farzin Roohvand; Arash Memarnejadian; Mohammad Reza Aghasadeghi; Sima Rafati
Construction of HCV-polytope vaccine candidates harbouring immune-enhancer sequences and primary evaluation of their immunogenicity in BALB/c mice.
Virus genes 2010;40(1):44-52.
2010: delaram doroud; Alireza Vatanara; Farnaz Zahedifard; Elham Gholami; Rouhollah Vahabpour; Abdolhossein Rouholamini Najafabadi; Sima Rafati
Cationic solid lipid nanoparticles loaded by cysteine proteinase genes as a novel anti-leishmaniasis DNA vaccine delivery system: characterization and in vitro evaluations.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2010;13(3):320-35.
2009: Amir Mizbani; Tahere Taheri; Farnaz Zahedifard; Yasaman Taslimi; Hiva Azizi; Kayhan Azadmanesh; Barbara Papadopoulou; Sima Rafati
Recombinant Leishmania tarentolae expressing the A2 virulence gene as a novel candidate vaccine against visceral leishmaniasis.
Vaccine 2009;28(1):53-62.
2009: Azam Bolhassani; Farnaz Zahedifard; Yasaman Taslimi; Mohammad Taghikhani; Bijan Nahavandian; Sima Rafati
Antibody detection against HPV16 E7 & GP96 fragments as biomarkers in cervical cancer patients.
The Indian journal of medical research 2009;130(5):533-41.
2009: Azam Bolhassani; Elham Mohit; Sima Rafati
Different spectra of therapeutic vaccine development against HPV infections.
Human vaccines 2009;5(10):671-89.
2009: H Azizi; K Hassani; Yasaman Taslimi; H Shateri Najafabadi; Barbara Papadopoulou; Sima Rafati
Searching for virulence factors in the non-pathogenic parasite to humans Leishmania tarentolae.
Parasitology 2009;136(7):723-35.
2009: Azam Bolhassani; Nahid Ghasemi; Catherine Servis; Mohammad Taghikhani; Sima Rafati
The efficiency of a novel delivery system (PEI600-Tat) in development of potent DNA vaccine using HPV16 E7 as a model antigen.
Drug delivery 2009;16(4):196-204.
2009: Jafar Amani; S Latif Mousavi; Sima Rafati; Ali H Salmanian
In silico analysis of chimeric espA, eae and tir fragments of Escherichia coli O157:H7 for oral immunogenic applications.
Theoretical biology & medical modelling 2009;6():28.
2009: Arash Memarnejadian; Farzin Roohvand; Arash Arashkia; Sima Rafati; Mohammad Ali Shokrgozar
Polytope DNA vaccine development against hepatitis C virus: a streamlined approach from in silico design to in vitro and primary in vivo analyses in BALB/c mice.
Protein and peptide letters 2009;16(7):842-50.
2008: Naghmeh Khoshgoo; Farnaz Zahedifard; Hiva Azizi; Yasaman Taslimi; Maribel Jiménez Alonso; Sima Rafati
Cysteine proteinase type III is protective against Leishmania infantum infection in BALB/c mice and highly antigenic in visceral leishmaniasis individuals.
Vaccine 2008;26(46):5822-9.
2008: Azam Bolhassani; Sima Rafati
Heat-shock proteins as powerful weapons in vaccine development.
Expert review of vaccines 2008;7(8):1185-99.
2008: Azam Bolhassani; Farnaz Zahedifard; Mohammad Taghikhani; Sima Rafati
Enhanced immunogenicity of HPV16E7 accompanied by Gp96 as an adjuvant in two vaccination strategies.
Vaccine 2008;26(26):3362-70.
2008: Adnene Salhi; Virmondes Rodrigues; Ferrucio Santoro; Helia Dessein; Audrey Romano; Lucio Roberto Castellano; Mathieu Sertorio; Sima Rafati; Christophe Chevillard; Aluisio Prata; Alexandre Alcaïs; Laurent Argiro; Alain Dessein
Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6139-48.
2008: Sima Rafati; Farnaz Zahedifard; Mahnaz Kakeh Azari; Yasaman Taslimi; Tahere Taheri
Leishmania infantum: prime boost vaccination with C-terminal extension of cysteine proteinase type I displays both type 1 and 2 immune signatures in BALB/c mice.
Experimental parasitology 2008;118(3):393-401.
2007: majid golkar; Sima Rafati; Mohamed S Abdel-Latif; Marie-Pierre Brenier-Pinchart; Hélène Fricker-Hidalgo; Baharak Khoshkholgh Sima; Jalal Babaie; Hervé Pelloux; Marie-France Cesbron-Delauw; Corinne Mercier
The dense granule protein GRA2, a new marker for the serodiagnosis of acute Toxoplasma infection: comparison of sera collected in both France and Iran from pregnant women.
Diagnostic microbiology and infectious disease 2007;58(4):419-26.
2007: majid golkar; Mohammad Ali Shokrgozar; Sima Rafati; Karine Musset; Mehdi Assmar; Reza Sadaie; Marie-France Cesbron-Delauw; Corinne Mercier
Evaluation of protective effect of recombinant dense granule antigens GRA2 and GRA6 formulated in monophosphoryl lipid A (MPL) adjuvant against Toxoplasma chronic infection in mice.
Vaccine 2007;25(21):4301-11.
2007: Sima Rafati; Elham Gholami; Nafiseh Hassani; Fatemeh Ghaemimanesh; Yasaman Taslimi; Tahere Taheri; Lynn Soong
Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in cutaneous and visceral leishmaniasis patients.
Vaccine 2007;25(21):4159-69.
2007: Nariman Aghaei Bandbon Balenga; Sima Rafati
Innate immune system: specific or non-specific?
Medical hypotheses 2007;69(2):460-1.
2006: Sima Rafati; Nafiseh Hassani; Yasaman Taslimi; Hesam Movassagh; Annie Rochette; Barbara Papadopoulou
Amastin peptide-binding antibodies as biomarkers of active human visceral leishmaniasis.
Clinical and vaccine immunology : CVI 2006;13(10):1104-10.
2006: Nariman Aghaei Bandbon Balenga; Farnaz Zahedifard; Richard Weiss; Mohammad N Sarbolouki; Josef Thalhamer; Sima Rafati
Protective efficiency of dendrosomes as novel nano-sized adjuvants for DNA vaccination against birch pollen allergy.
Journal of biotechnology 2006;124(3):602-14.
2006: Sima Rafati; Fatemeh Ghaemimanesh; Farnaz Zahedifard
Comparison of potential protection induced by three vaccination strategies (DNA/DNA, Protein/Protein and DNA/Protein) against Leishmania major infection using Signal Peptidase type I in BALB/c mice.
Vaccine 2006;24(16):3290-7.
2006: Sima Rafati; Farnaz Zahedifard; Fereshteh Nazgouee
Prime-boost vaccination using cysteine proteinases type I and II of Leishmania infantum confers protective immunity in murine visceral leishmaniasis.
Vaccine 2006;24(12):2169-75.
2006: Ali Khamesipour; Sima Rafati; Noushin Davoudi; Fereidoun Maboudi; Farrokh Modabber
Leishmaniasis vaccine candidates for development: a global overview.
The Indian journal of medical research 2006;123(3):423-38.
2005: Sima Rafati; Alireza Nakhaee; Tahere Taheri; Yasaman Taslimi; Haiedeh Darabi; Davood Eravani; Stephanie L Sanos; Paul Kaye; Mohammad Taghikhani; Shahram Jamshidi; Mohammad Ali Rad
Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum.
Vaccine 2005;23(28):3716-25.
2004: Azita Zadeh-Vakili; Tahere Taheri; Yasaman Taslimi; Fatemeh Doustdari; Ali Hatef Salmanian; Sima Rafati
Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis.
Vaccine 2004;22(15-16):1930-40.
2004: Sima Rafati; Ali Hatef Salmanian; Tahere Taheri; Slavica Masina; Cédric Schaff; Yasaman Taslimi; Nicolas Fasel
Type I signal peptidase from Leishmania is a target of the immune response in human cutaneous and visceral leishmaniasis.
Molecular and biochemical parasitology 2004;135(1):13-20.
2004: Alireza Nakhaee; Tahere Taheri; Mohammad Taghikhani; Mehdi Mohebali; Ali Hatef Salmanian; Nicolas Fasel; Sima Rafati
Humoral and cellular immune responses against Type I cysteine proteinase of Leishmania infantum are higher in asymptomatic than symptomatic dogs selected from a naturally infected population.
Veterinary parasitology 2004;119(2-3):107-23.
2003: Mahmood Mahmoodi; Ali Khamesipour; Yahya Dowlati; Sima Rafati; Ali Z Momeni; M Emamjomeh; H Hejazi; Farrokh Modabber
Immune response measured in human volunteers vaccinated with autoclaved Leishmania major vaccine mixed with low dose of BCG.
Clinical and experimental immunology 2003;134(2):303-8.
2003: Parvarich Farzaneh; Massoumeh Ebtekar; Zuhair M Hassan; Sima Rafati
Murine cytokine patterns following rubella vaccination.
Iranian journal of allergy, asthma, and immunology 2003;2(2):89-93.
2003: Hervé Pascalis; Anne Lavergne; Eliane Bourreau; Ghislaine Prévot-Linguet; Amina Kariminia; Roger Pradinaud; Sima Rafati; Pascal Launois
Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis.
Infection and immunity 2003;71(5):2924-6.
2003: Sima Rafati; Alireza Nakhaee; Tahere Taheri; Andishe Ghashghaii; Ali Hatef Salmanian; Maribel Jimenez; Mehdi Mohebali; Slavica Masina; Nicolas Fasel
Expression of cysteine proteinase type I and II of Leishmania infantum and their recognition by sera during canine and human visceral leishmaniasis.
Experimental parasitology 2003;103(3-4):143-51.
2002: Sima Rafati; Amina Kariminia; Shiva Seyde-Eslami; Manijeh Narimani; Tahere Taheri; Mai Lebbatard
Recombinant cysteine proteinases-based vaccines against Leishmania major in BALB/c mice: the partial protection relies on interferon gamma producing CD8(+) T lymphocyte activation.
Vaccine 2002;20(19-20):2439-47.
2001: Sima Rafati; Ali Hatef Salmanian; Tahere Taheri; M Vafa; Nicolas Fasel
A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major.
Vaccine 2001;19(25-26):3369-75.
2001: Sima Rafati; Ali Hatef Salmanian; K Hashemi; Cédric Schaff; Sabina I Belli; Nicolas Fasel
Identification of Leishmania major cysteine proteinases as targets of the immune response in humans.
Molecular and biochemical parasitology 2001;113(1):35-43.
2000: Sima Rafati; A A Baba; M Bakhshayesh; M Vafa
Vaccination of BALB/c mice with Leishmania major amastigote-specific cysteine proteinase.
Clinical and experimental immunology 2000;120(1):134-8.
1999: N Solioz; U Blum-Tirouvanziam; R Jacquet; Sima Rafati; Giampietro Corradin; Jacques Mauël; Nicolas Fasel
The protective capacities of histone H1 against experimental murine cutaneous leishmaniasis.
Vaccine 1999;18(9-10):850-9.
1997: Sima Rafati; S Couty-Jouve; Mohammad Hossein Alimohammadian; J A Louis
Biochemical analysis and immunogenicity of Leishmania major amastigote fractions in cutaneous leishmaniasis.
Clinical and experimental immunology 1997;110(2):203-11.