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Shahin Rafii

Research Profile

Living Beings

Mouse

Anatomy

Chemicals & Drugs

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Neovascularization, Pathologic

Physiology

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TOP 3
S Jain; N Kornhauser; C Lam; M E Lane; C Mathijsen Greenwood; V Mittal; A Moore; Shahin Rafii; S Schneider; S Benkert; E Chuang; Tessa Cigler; M V Cobham; J Cohen; D Donovan; S M Hurtado Rúa; M M Ward; J D Warren; R Zelkowitz; Linda Vahdat
Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse.
Raphael Lis; Shahin Rafii; Daylon James
Wading through the waves of human embryonic hemogenesis.
Fabienne Brenet; Pouneh Kermani; Shahin Rafii; Roman Spektor; Joseph Michael Scandura
TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy.

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All Publications

2013: S Jain; N Kornhauser; C Lam; M E Lane; C Mathijsen Greenwood; V Mittal; A Moore; Shahin Rafii; S Schneider; S Benkert; E Chuang; Tessa Cigler; M V Cobham; J Cohen; D Donovan; S M Hurtado Rúa; M M Ward; J D Warren; R Zelkowitz; Linda Vahdat
Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2013;24(6):1491-8.
2013: Raphael Lis; Shahin Rafii; Daylon James
Wading through the waves of human embryonic hemogenesis.
Cell cycle (Georgetown, Tex.) 2013;12(6):859-60.
2013: Fabienne Brenet; Pouneh Kermani; Shahin Rafii; Roman Spektor; Joseph Michael Scandura
TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy.
The Journal of experimental medicine 2013;210(3):623-39.
2013: Shahin Rafii; Zev Rosenwaks; Michel Sadelain; Jenny Xiang; Nikica Zaninovic; Qiansheng Zhan; Jason M Butler; Bi-Sen Ding; Olivier Elemento; Eric Gars; Michael Ginsberg; Pavle Josipovic; Christopher C Kloss; Raphael Lis; Jeremie A Rafii; Daylon James
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition.
Blood 2013;121(5):770-80.
2013: Peter E Westerweel; Ian A White; Pieter A Doevendans; Andrea T Hooper; Janneke E Jaspers; Shahin Rafii; Martin Teraa; Marianne C Verhaar
Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus.
PloS one 2013;8(3):e60357.
2012: timothy hla; Sylvain Galvani; Shahin Rafii; Ralph Nachman
S1P and the birth of platelets.
The Journal of experimental medicine 2012;209(12):2137-40.
2012: Michael Ginsberg; Daylon James; Susan Mathew; Daniel Nolan; Venkat R Pulijaal; Sina Y Rabbany; Jason M Butler; Stephen T Chasen; Bi-Sen Ding; Olivier Elemento; Fuqiang Geng; Zev Rosenwaks; William Schachterle; Koji Shido; Jenny Xiang; Shahin Rafii
Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression.
Cell 2012;151(3):559-75.
2012: Eric Gars; Shahin Rafii
It takes 2 to thrombopoies in the vascular niche.
Blood 2012;120(14):2775-6.
2012: Bongnam Jung; Bernd Kinzel; Karen Mendelson; Hideru Obinata; Shahin Rafii; Athanasia Skoura; Volker Brinkmann; Bi-Sen Ding; Todd Evans; Sylvain Galvani; Timothy Hla
Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.
Developmental cell 2012;23(3):600-10.
2012: Giacomo Curradi; Bi-Sen Ding; Neil R Hackett; Shahin Rafii; Matthew S Walters; Ronald G Crystal
Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells.
Cellular and molecular life sciences : CMLS 2012;69(13):2217-31.
2012: Sarika Jain; Christina Lam; Maureen E Lane; Vivek Mittal; Anne Moore; Jennifer O'Loughlin; Shahin Rafii; Sarah Schneider; Alexander Swistel; Rebecca N Baergen; Marissa Boeck; Paul Christos; Ellen Chuang; Tessa Cigler; Marta V Cobham; Diana Donovan; Maureen M Ward; Naomi Wiener; Linda Vahdat
Incremental increase in VEGFR1⁺ hematopoietic progenitor cells and VEGFR2⁺ endothelial progenitor cells predicts relapse and lack of tumor response in breast cancer patients.
Breast cancer research and treatment 2012;132(1):235-42.
2012: Jason M Butler; Shahin Rafii
Generation of a vascular niche for studying stem cell homeostasis.
Methods in molecular biology (Clifton, N.J.) 2012;904():221-33.
2011: Bi-Sen Ding; Peipei Guo; Daniel J Nolan; Sina Y Rabbany; Zev Rosenwaks; Thomas N Sato; Koji Shido; Michael Simons; Stefan Worgall; Alexander O Babazadeh; Zhongwei Cao; Ronald G Crystal; Shahin Rafii
Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization.
Cell 2011;147(3):539-53.
2011: Peter W Henderson; Sunil P Singh; David D Krijgh; Masaya Yamamoto; Daniel C Rafii; Josephine J Sung; Shahin Rafii; Sina Y Rabbany; Jason A Spector
Stromal-derived factor-1 delivered via hydrogel drug-delivery vehicle accelerates wound healing in vivo.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2011;19(3):420-5.
2011: Daylon James; Qiansheng Zhan; Christopher Kloss; Nikica Zaninovic; Zev Rosenwaks; Shahin Rafii
Lentiviral transduction and clonal selection of hESCs with endothelial-specific transgenic reporters.
Current protocols in stem cell biology 2011;Chapter 1():Unit1F.12.
2011: Seandel Marco; Shahin Rafii
Reproductive biology: In vitro sperm maturation.
Nature 2011;471(7339):453-5.
2011: Adília Hormigo; Bi-Sen Ding; Shahin Rafii
A target for antiangiogenic therapy: vascular endothelium derived from glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(11):4271-2.
2011: Catia C Proenca; Kate P Gao; Sergey V Shmelkov; Shahin Rafii; Francis S Lee
Slitrks as emerging candidate genes involved in neuropsychiatric disorders.
Trends in neurosciences 2011;34(3):143-53.
2011: Yuki Kimura; Daniel J Nolan; Jason M Butler; Bisen Ding; Norikazu Imai; Shahin Rafii
c-Kit-mediated functional positioning of stem cells to their niches is essential for maintenance and regeneration of adult hematopoiesis.
PloS one 2011;6(10):e26918.
2010: Bi-Sen Ding; Daniel J Nolan; Jason M Butler; Daylon James; Alexander O Babazadeh; Zev Rosenwaks; Vivek Mittal; Hideki Kobayashi; Koji Shido; David Lyden; Thomas N Sato; Sina Y Rabbany; Shahin Rafii
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration.
Nature 2010;468(7321):310-5.
2010: Hideki Kobayashi; Jason M Butler; Rebekah O'Donnell; Mariko Kobayashi; Bi-Sen Ding; Bryant Bonner; Vi K Chiu; Daniel J Nolan; Koji Shido; Laura Benjamin; Shahin Rafii
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells.
Nature cell biology 2010;12(11):1046-56.
2010: María García-Fernández; Holger Kissel; Samara Brown; Travis Gorenc; Andrew J Schile; Shahin Rafii; Sarit Larisch; Hermann Steller
Sept4/ARTS is required for stem cell apoptosis and tumor suppression.
Genes & development 2010;24(20):2282-93.
2010: Udit Agarwal; Wael Ghalayini; Feng Dong; Kristal Weber; Yong-Rui Zou; Sina Y Rabbany; Shahin Rafii; Marc S Penn
Role of cardiac myocyte CXCR4 expression in development and left ventricular remodeling after acute myocardial infarction.
Circulation research 2010;107(5):667-76.
2010: Robin M Hobbs; Seandel Marco; Ilaria Falciatori; Shahin Rafii; Pier Paolo Pandolfi
Plzf regulates germline progenitor self-renewal by opposing mTORC1.
Cell 2010;142(3):468-79.
2010: Sina Y Rabbany; Daylon James; Shahin Rafii
New dimensions in vascular engineering: opportunities for cancer biology.
Tissue engineering. Part A 2010;16(7):2157-9.
2010: Shahin Rafii; Daniel Nolan
Cholesterol activates vascular niche and hematopoiesis.
Blood 2010;115(19):3857-8.
2010: Sergey V Shmelkov; Adília Hormigo; Deqiang Jing; Catia C Proenca; Kevin G Bath; Till Milde; Evgeny Shmelkov; Jared S Kushner; Muhamed Baljevic; Iva Dincheva; Andrew J Murphy; David M Valenzuela; Nicholas W Gale; George D Yancopoulos; Ipe Ninan; Francis S Lee; Shahin Rafii
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice.
Nature medicine 2010;16(5):598-602, 1p following 602.
2010: Aaron D Goldberg; Laura A Banaszynski; Kyung-Min Noh; Peter Lewis; Simon J Elsaesser; Sonja Stadler; Scott Dewell; Martin Law; Xingyi Guo; Xuan Li; Duancheng Wen; Ariane Chapgier; Russell C DeKelver; Jeffrey C Miller; Ya-Li Lee; Elizabeth A Boydston; Michael C Holmes; Philip D Gregory; John M Greally; Shahin Rafii; Chingwen Yang; Peter J Scambler; David Garrick; Richard J Gibbons; Douglas R Higgs; Ileana M Cristea; Fyodor D Urnov; Deyou Zheng; C David Allis
Distinct factors control histone variant H3.3 localization at specific genomic regions.
Cell 2010;140(5):678-91.
2010: Jason M Butler; Daniel J Nolan; Eva L Vertes; Barbara Varnum-Finney; Hideki Kobayashi; Andrea T Hooper; Seandel Marco; Koji Shido; Ian A White; Mariko Kobayashi; Larry Witte; Chad May; Carrie Shawber; Yuki Kimura; Jan Kitajewski; Zev Rosenwaks; Irwin D Bernstein; Shahin Rafii
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.
Cell stem cell 2010;6(3):251-64.
2010: Jason M Butler; Hideki Kobayashi; Shahin Rafii
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors.
Nature reviews. Cancer 2010;10(2):138-46.
2010: Daylon James; Hyung-song Nam; Seandel Marco; Daniel Nolan; Tyler Janovitz; Mark J Tomishima; Studer Lorenz; Gabsang Lee; David Lyden; Robert Benezra; Nikica Zaninovic; Zev Rosenwaks; Sina Y Rabbany; Shahin Rafii
Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent.
Nature biotechnology 2010;28(2):161-6.
2010: Sina Y Rabbany; Joseph Pastore; Masaya Yamamoto; Tim Miller; Shahin Rafii; Rahul Aras; Marc Penn
Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing.
Cell transplantation 2010;19(4):399-408.
2010: Masaya Yamamoto; Daylon James; Hui Li; Jason Butler; Shahin Rafii; Sina Rabbany
Generation of stable co-cultures of vascular cells in a honeycomb alginate scaffold.
Tissue engineering. Part A 2010;16(1):299-308.
2009: Lin Chen; J. Jue Zhang; Shahin Rafii; Xin-Yun Huang
Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency.
The Journal of biological chemistry 2009;284(40):27409-15.
2009: Hans-Georg Kopp; Andrea T Hooper; Scott T Avecilla; Shahin Rafii
Functional heterogeneity of the bone marrow vascular niche.
Annals of the New York Academy of Sciences 2009;1176():47-54.
2009: Andrea T Hooper; Sergey V Shmelkov; Sunny Gupta; Till Milde; Kathryn Bambino; Kelly Gillen; Mollie Goetz; Sai Chavala; Muhamed Baljevic; Andrew J Murphy; David M Valenzuela; Nicholas W Gale; Gavin Thurston; George D Yancopoulos; Linda Vahdat; Todd Evans; Shahin Rafii
Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.
Circulation research 2009;105(2):201-8.
2009: Fan Zhang; Shirling Tsai; Kaori Kato; Dai Yamanouchi; Chunjie Wang; Shahin Rafii; Bo Liu; K Craig Kent
Transforming growth factor-beta promotes recruitment of bone marrow cells and bone marrow-derived mesenchymal stem cells through stimulation of MCP-1 production in vascular smooth muscle cells.
The Journal of biological chemistry 2009;284(26):17564-74.
2009: Jeffrey P Greenfield; David K Jin; Lauren M Young; Paul J Christos; Lauren E Abrey; Shahin Rafii; Philip H Gutin
Surrogate markers predict angiogenic potential and survival in patients with glioblastoma multiforme.
Neurosurgery 2009;64(5):819-26; discussion 826-7.
2009: Ben A Gyan; Bamenla Q Goka; George O Adjei; John K A Tetteh; Kwadwo Asamoah Kusi; Anastasia Aikins; Daniel Dodoo; Martin L Lesser; Cristina P Sison; Sanchita Das; Marion E Howard; Elizabeth Milbank; Kimberly Fischer; Shahin Rafii; David Jin; Linnie M Golightly
Cerebral malaria is associated with low levels of circulating endothelial progenitor cells in African children.
The American journal of tropical medicine and hygiene 2009;80(4):541-6.
2009: Andrea T Hooper; Jason M Butler; Daniel J Nolan; Andrea Kranz; Kaoruko Iida; Mariko Kobayashi; Hans-Georg Kopp; Koji Shido; Isabelle Petit; Kilangsungla Yanger; Daylon James; Larry Witte; Zhenping Zhu; Yan Wu; Bronislaw Pytowski; Zev Rosenwaks; Vivek Mittal; Thomas N Sato; Shahin Rafii
Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells.
Cell stem cell 2009;4(3):263-74.
2009: J Ruan; K Hajjar; Shahin Rafii; J P Leonard
Angiogenesis and antiangiogenic therapy in non-Hodgkin's lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2009;20(3):413-24.
2009: Shirling Tsai; Jason Butler; Shahin Rafii; Bo Liu; K Kent
The role of progenitor cells in the development of intimal hyperplasia.
Journal of vascular surgery 2009;49(2):502-10.
2009: April S Chan; Kristian K Jensen; Dimitris Skokos; Stephen Doty; Hannah K Lederman; Rosandra N Kaplan; Shahin Rafii; Stefano Rivella; David Lyden
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.
PloS one 2009;4(11):e7955.
2009: Emmanuelle Passegué; Shahin Rafii; Meenhard Herlyn
Cancer stem cells are everywhere.
Nature medicine 2009;15(1):23.
2008: Seandel Marco; Jason M Butler; Hideki Kobayashi; Andrea T Hooper; Ian A White; Fan Zhang; Eva L Vertes; Mariko Kobayashi; Yan Zhang; Sergey V Shmelkov; Neil R Hackett; Sina Rabbany; Julie L Boyer; Shahin Rafii
Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19288-93.
2008: Héctor Peinado; Shahin Rafii; David Lyden
Inflammation joins the "niche".
Cancer cell 2008;14(5):347-9.
2008: Peter E Westerweel; Frank L J Visseren; Gideon R Hajer; Jobien K Olijhoek; Imo E Hoefer; Petra de Bree; Shahin Rafii; Pieter A Doevendans; Marianne C Verhaar
Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy.
European heart journal 2008;29(22):2808-17.
2008: Steven Swendeman; Karen Mendelson; Gisela Weskamp; Keisuke Horiuchi; Urban Deutsch; Peggy Scherle; Andrea Hooper; Shahin Rafii; Carl P Blobel
VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling.
Circulation research 2008;103(9):916-8.
2008: Jiyeon Kim; Seandel Marco; Ilaria Falciatori; Duancheng Wen; Shahin Rafii
CD34+ testicular stromal cells support long-term expansion of embryonic and adult stem and progenitor cells.
Stem cells (Dayton, Ohio) 2008;26(10):2516-22.
2008: Ralph L Nachman; Shahin Rafii
Platelets, petechiae, and preservation of the vascular wall.
The New England journal of medicine 2008;359(12):1261-70.
2008: Robert S Kerbel; Robert Benezra; David C Lyden; Koichi Hattori; Beate Heissig; Daniel J Nolan; Vivek Mittal; Yuval Shaked; Sergio Dias; Francesco Bertolini; Shahin Rafii
Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):E54; author reply E55.
2008: Daylon James; Sina Rabbany; Shahin Rafii
Hitting the mother lode of tumor angiogenesis.
Nature biotechnology 2008;26(7):769-70.
2008: Abby B Siegel; Emil I Cohen; Allyson Ocean; Deborah Lehrer; Alec Goldenberg; Jennifer J Knox; Helen Chen; Sean Clark-Garvey; Alan Weinberg; John Mandeli; Paul Christos; Madhu Mazumdar; Elizabeta Popa; Robert S Brown; Shahin Rafii; Jonathan D Schwartz
Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(18):2992-8.
2008: Sergey V Shmelkov; Jason M Butler; Andrea T Hooper; Adília Hormigo; Jared Kushner; Till Milde; Ryan St Clair; Muhamed Baljevic; Ian White; David K Jin; Amy Chadburn; Andrew J Murphy; David M Valenzuela; nicholas gale; Gavin Thurston; George D Yancopoulos; Michael D'Angelica; Nancy Kemeny; David Lyden; Shahin Rafii
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.
The Journal of clinical investigation 2008;118(6):2111-20.
2008: Seandel Marco; Jason Butler; David Lyden; Shahin Rafii
A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization.
Cancer cell 2008;13(3):181-3.
2008: Jared Wels; Rosandra N Kaplan; Shahin Rafii; David Lyden
Migratory neighbors and distant invaders: tumor-associated niche cells.
Genes & development 2008;22(5):559-74.
2008: Isabelle Petit; Matthias A Karajannis; Loic Vincent; Lauren Young; Jason Butler; Andrea T Hooper; Koji Shido; Hermann Steller; David J Chaplin; Eric Feldman; Shahin Rafii
The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death.
Blood 2008;111(4):1951-61.
2008: Seandel Marco; Ilaria Falciatori; Sergey V Shmelkov; Jiyeon Kim; Daylon James; Shahin Rafii
Niche players: spermatogonial progenitors marked by GPR125.
Cell cycle (Georgetown, Tex.) 2008;7(2):135-40.
2008: Shahin Rafii; David Lyden
Cancer. A few to flip the angiogenic switch.
Science (New York, N.Y.) 2008;319(5860):163-4.
2008: Rakhi P Naik; David Jin; Ellen Chuang; Ellen G Gold; Eleni Tousimis; Anne L Moore; Paul J Christos; Tatiana de Dalmas; Diana Donovan; Shahin Rafii; Linda Vahdat
Circulating endothelial progenitor cells correlate to stage in patients with invasive breast cancer.
Breast cancer research and treatment 2008;107(1):133-8.
2007: Seandel Marco; Daylon James; Sergey V Shmelkov; Ilaria Falciatori; Jiyeon Kim; Sai Chavala; Douglas Scherr; Fan Zhang; Richard Torres; nicholas gale; George D Yancopoulos; Andrew Murphy; David M Valenzuela; Robin M Hobbs; Pier Paolo Pandolfi; Shahin Rafii
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Nature 2007;449(7160):346-50.
2007: Hans-Georg Kopp; A T Hooper; Sergey V Shmelkov; Shahin Rafii
Beta-galactosidase staining on bone marrow. The osteoclast pitfall.
Histology and histopathology 2007;22(9):971-6.
2007: Andrea T Hooper; Jason Butler; Isabelle Petit; Shahin Rafii
Does N-cadherin regulate interaction of hematopoietic stem cells with their niches?
Cell stem cell 2007;1(2):127-9.
2007: Isabelle Petit; David Jin; Shahin Rafii
The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis.
Trends in immunology 2007;28(7):299-307.
2007: H G Kopp; Shahin Rafii
Thrombopoietic cells and the bone marrow vascular niche.
Annals of the New York Academy of Sciences 2007;1106():175-9.
2007: Mahmoud Kiaei; Khatuna Kipiani; Noel Y Calingasan; Elizabeth Wille; Junyu Chen; Beate Heissig; Shahin Rafii; Stefan Lorenzl; M Flint Beal
Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis.
Experimental neurology 2007;205(1):74-81.
2007: T Milde; Sergey V Shmelkov; Kristian K Jensen; G Zlotchenko; Isabelle Petit; Shahin Rafii
A novel family of slitrk genes is expressed on hematopoietic stem cells and leukemias.
Leukemia 2007;21(4):824-7.
2007: Agata D'Agostino Mutlu; Lucas E Cavallin; Loïc Vincent; Chiara Chiozzini; Pilar Eroles; Elda M Duran; Zahra Asgari; Andrea T Hooper; Krista M D La Perle; Chelsey Hilsher; Shou-Jiang Gao; Dirk P Dittmer; Shahin Rafii; Enrique Mesri
In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma.
Cancer cell 2007;11(3):245-58.
2007: Adília Hormigo; Philip H Gutin; Shahin Rafii
Tracking normalization of brain tumor vasculature by magnetic imaging and proangiogenic biomarkers.
Cancer cell 2007;11(1):6-8.
2006: Rosandra N Kaplan; Shahin Rafii; David Lyden
Preparing the "soil": the premetastatic niche.
Cancer research 2006;66(23):11089-93.
2006: Hans-Georg Kopp; Andrea T Hooper; M Johan Broekman; Scott T Avecilla; Isabelle Petit; Min Luo; Till Milde; Carlos A Ramos; Fan Zhang; Tabitha Kopp; Paul Bornstein; David K Jin; Aaron J Marcus; Shahin Rafii
Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.
The Journal of clinical investigation 2006;116(12):3277-91.
2006: Shahin Rafii; David Lyden
S100 chemokines mediate bookmarking of premetastatic niches.
Nature cell biology 2006;8(12):1321-3.
2006: Jia Ruan; Elizabeth Hyjek; Pouneh Kermani; Paul J Christos; Andrea T Hooper; Morton Coleman; Barbara L Hempstead; John P Leonard; Amy Chadburn; Shahin Rafii
Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5622-31.
2006: Yan Wu; Andrea T Hooper; Zhaojing Zhong; Larry Witte; Peter Bohlen; Shahin Rafii; Daniel J Hicklin
The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma.
International journal of cancer. Journal international du cancer 2006;119(7):1519-29.
2006: Rosa Bernardi; Ilhem Guernah; David Jin; Silvia Grisendi; Andrea Alimonti; Julie T Feldstein; Carlos Cordon-Cardo; M Celeste Simon; Shahin Rafii; Pier Paolo Pandolfi
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.
Nature 2006;442(7104):779-85.
2006: Matthias A Karajannis; L Vincent; R Direnzo; Sergey V Shmelkov; Fan Zhang; E J Feldman; Peter Bohlen; Z Zhu; H Sun; Paul Kussie; Shahin Rafii
Activation of FGFR1beta signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells.
Leukemia 2006;20(6):979-86.
2006: Michael L Cher; Dwight A Towler; Shahin Rafii; David Rowley; Henry J Donahue; Evan T Keller; Meenhard Herlyn; Eun Ah Cho; Leland W K Chung
Cancer interaction with the bone microenvironment: a workshop of the National Institutes of Health Tumor Microenvironment Study Section.
The American journal of pathology 2006;168(5):1405-12.
2006: David K Jin; Koji Shido; Hans-Georg Kopp; Isabelle Petit; Sergey V Shmelkov; Lauren M Young; Andrea T Hooper; Hideki Amano; Scott T Avecilla; Beate Heissig; Koichi Hattori; Fan Zhang; Daniel J Hicklin; Yan Wu; Zhenping Zhu; Ashley Dunn; Hassan Salari; Zena Werb; Neil R Hackett; Helen-Ann Brown Epstein; David Lyden; Shahin Rafii
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes.
Nature medicine 2006;12(5):557-67.
2006: Hans-Georg Kopp; Carlos A Ramos; Shahin Rafii
Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue.
Current opinion in hematology 2006;13(3):175-81.
2005: Rosandra N Kaplan; Rebecca D Riba; Stergios Zacharoulis; Anna H Bramley; Loïc Vincent; Carla Costa; Daniel D MacDonald; David K Jin; Koji Shido; Scott Kerns; Zhenping Zhu; Daniel J Hicklin; Yan Wu; Jeffrey L Port; Nasser K Altorki; Elisa Rush Port; Davide Ruggero; Sergey V Shmelkov; Kristian K Jensen; Shahin Rafii; David Lyden
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.
Nature 2005;438(7069):820-7.
2005: Loïc Vincent; Pouneh Kermani; Lauren M Young; Joseph Cheng; Fan Zhang; Koji Shido; George Lam; Heidi Bompais-Vincent; Zhenping Zhu; Daniel J Hicklin; Peter Bohlen; David J Chaplin; Chad May; Shahin Rafii
Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling.
The Journal of clinical investigation 2005;115(11):2992-3006.
2005: Pierre Feugier; Na Li; Deog-Yeon Jo; Jae-Hung Shieh; Karen L MacKenzie; J F Lesesve; Véronique Latger-Cannard; Danièle Bensoussan; Helen-Ann Brown Epstein; Shahin Rafii; J F Stoltz; Malcolm A S Moore
Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro.
Stem cells and development 2005;14(5):505-16.
2005: Loïc Vincent; Patricia Avancena; Joseph Cheng; Shahin Rafii; Sina Y Rabbany
Simulated microgravity impairs leukemic cell survival through altering VEGFR-2/VEGF-A signaling pathway.
Annals of biomedical engineering 2005;33(10):1405-10.
2005: Hans-Georg Kopp; Scott T Avecilla; Andrea T Hooper; Shahin Rafii
The bone marrow vascular niche: home of HSC differentiation and mobilization.
Physiology (Bethesda, Md.) 2005;20():349-56.
2005: Beate Heissig; Shahin Rafii; Haruyo Akiyama; Yuichi Ohki; Yayoi Sato; Tejada Rafael; Zhenping Zhu; Daniel J Hicklin; Ko Okumura; Hideoki Ogawa; Zena Werb; Koichi Hattori
Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization.
The Journal of experimental medicine 2005;202(6):739-50.
2005: Hideki Amano; Neil R Hackett; Shahin Rafii; Helen-Ann Brown Epstein
Thrombopoietin gene transfer-mediated enhancement of angiogenic responses to acute ischemia.
Circulation research 2005;97(4):337-45.
2005: Hans-Georg Kopp; Scott T Avecilla; Andrea T Hooper; Sergey V Shmelkov; Carlos A Ramos; Fan Zhang; Shahin Rafii
Tie2 activation contributes to hemangiogenic regeneration after myelosuppression.
Blood 2005;106(2):505-13.
2005: Beate Heissig; Yuichi Ohki; Yayoi Sato; Shahin Rafii; Zena Werb; Koichi Hattori
A role for niches in hematopoietic cell development.
Hematology (Amsterdam, Netherlands) 2005;10(3):247-53.
2005: Fan Zhang; Joseph Cheng; George Lam; David K Jin; Loïc Vincent; Neil R Hackett; Shiyang Wang; Lauren M Young; Barbara L Hempstead; Helen-Ann Brown Epstein; Shahin Rafii
Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways.
Circulation research 2005;96(9):950-7.
2005: Anxo Vidal; Stergios Zacharoulis; Wenjun Guo; David Shaffer; Filippo G Giancotti; Anna H Bramley; Carmen de la Hoz; Kristian K Jensen; Daniel Kato; Daniel D MacDonald; Joseph Knowles; Nancy Yeh; Lawrence A Frohman; Shahin Rafii; David Lyden; Andrew Koff
p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6890-5.
2005: Loïc Vincent; David K Jin; Matthias A Karajannis; Koji Shido; Andrea T Hooper; William K Rashbaum; Bronislaw Pytowski; Yan Wu; Daniel J Hicklin; Zhenping Zhu; Peter Bohlen; Ruben Niesvizky; Shahin Rafii
Fetal stromal-dependent paracrine and intracrine vascular endothelial growth factor-a/vascular endothelial growth factor receptor-1 signaling promotes proliferation and motility of human primary myeloma cells.
Cancer research 2005;65(8):3185-92.
2005: Sergey V Shmelkov; Ryan St Clair; David Lyden; Shahin Rafii
AC133/CD133/Prominin-1.
The international journal of biochemistry & cell biology 2005;37(4):715-9.
2005: Sergey V Shmelkov; Sarah Meeus; Nelson Moussazadeh; Pouneh Kermani; William K Rashbaum; Sina Y Rabbany; Marilee A Hanson; William J Lane; Ryan St Clair; Kathryn A Walsh; Sergio Dias; Jason T Jacobson; Barbara L Hempstead; Jay M Edelberg; Shahin Rafii
Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissue.
Circulation 2005;111(9):1175-83.
2005: Pouneh Kermani; Dahlia Rafii; David K Jin; Paul Whitlock; Wendy Lynn Schaffer; Anne Chiang; Loïc Vincent; Matthias Friedrich; Koji Shido; Neil R Hackett; Helen-Ann Brown Epstein; Shahin Rafii; Barbara L Hempstead
Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors.
The Journal of clinical investigation 2005;115(3):653-63.
2004: Loïc Vincent; Shahin Rafii
Vascular frontiers without borders: multifaceted roles of platelet-derived growth factor (PDGF) in supporting postnatal angiogenesis and lymphangiogenesis.
Cancer cell 2004;6(4):307-9.
2004: Richard T Silver; john bennett; Michael W N Deininger; Eric Feldman; Shahin Rafii; R L Silverstein; Lawrence Solberg; Jerry L Spivak
The second international congress on myeloproliferative and myelodysplastic syndromes.
Leukemia research 2004;28(9):979-85.
2004: Munira Xaymardan; Lilong Tang; Leze Zagreda; Benedetta A Pallante; Jingang Zheng; Joseph L Chazen; Andrew Chin; Inga Duignan; Patrick C Nahirney; Shahin Rafii; Takashi Mikawa; Jay M Edelberg
Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes.
Circulation research 2004;94(5):E39-45.
2004: Fan Zhang; Joseph Cheng; Neil R Hackett; George Lam; Koji Shido; Robert Pergolizzi; David K Jin; Helen-Ann Brown Epstein; Shahin Rafii
Adenovirus E4 gene promotes selective endothelial cell survival and angiogenesis via activation of the vascular endothelial-cadherin/Akt signaling pathway.
The Journal of biological chemistry 2004;279(12):11760-6.
2004: Sergey V Shmelkov; Lin Jun; Ryan St Clair; Deirdre McGarrigle; Christopher A Derderian; Jaroslav K Usenko; Carla Costa; Fan Zhang; Xinzheng Guo; Shahin Rafii
Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133.
Blood 2004;103(6):2055-61.
2004: Robert Benezra; Shahin Rafii
Endostatin's endpoints-Deciphering the endostatin antiangiogenic pathway.
Cancer cell 2004;5(3):205-6.
2004: Anja Moldenhauer; Marcelo Nociari; George Lam; Abdulgabar Salama; Shahin Rafii; Malcolm A S Moore
Tumor necrosis factor alpha-stimulated endothelium: an inducer of dendritic cell development from hematopoietic progenitors and myeloid leukemic cells.
Stem cells (Dayton, Ohio) 2004;22(2):144-57.
2004: Scott T Avecilla; Koichi Hattori; Beate Heissig; Rafael Tejada; Fang Liao; Koji Shido; David K Jin; Sergio Dias; Fan Zhang; Travis E Hartman; Neil R Hackett; Helen-Ann Brown Epstein; Larry Witte; Daniel J Hicklin; Peter Bohlen; Dan Eaton; David Lyden; Frederic J de Sauvage; Shahin Rafii
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.
Nature medicine 2004;10(1):64-71.
2003: Shahin Rafii; Scott T Avecilla; David K Jin
Tumor vasculature address book: identification of stage-specific tumor vessel zip codes by phage display.
Cancer cell 2003;4(5):331-3.
2003: Marianna B Ruzinova; Rebecca A Schoer; William Gerald; James Egan; Pier Paolo Pandolfi; Shahin Rafii; Katia Manova-Todorova; Vivek Mittal; Robert Benezra
Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors.
Cancer cell 2003;4(4):277-89.
2003: Beate Heissig; Zena Werb; Shahin Rafii; Koichi Hattori
Role of c-kit/Kit ligand signaling in regulating vasculogenesis.
Thrombosis and haemostasis 2003;90(4):570-6.
2003: Fan Zhang; Neil R Hackett; George Lam; Joseph Cheng; Robert Pergolizzi; Lan Luo; Sergey V Shmelkov; Jay M Edelberg; Helen-Ann Brown Epstein; Shahin Rafii
Green fluorescent protein selectively induces HSP70-mediated up-regulation of COX-2 expression in endothelial cells.
Blood 2003;102(6):2115-21.
2003: Jay M Edelberg; Munira Xaymardan; Shahin Rafii; Mun K Hong
Adult cardiac stem cells--where do we go from here?
Science of aging knowledge environment : SAGE KE 2003;2003(26):PE17.
2003: Shahin Rafii; David Lyden
Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration.
Nature medicine 2003;9(6):702-12.
2003: Monica Garcia-Barros; François Paris; Carlos Cordon-Cardo; David Lyden; Shahin Rafii; Adriana Haimovitz-Friedman; Zvi Fuks; Richard Kolesnick
Tumor response to radiotherapy regulated by endothelial cell apoptosis.
Science (New York, N.Y.) 2003;300(5622):1155-9.
2003: Shahin Rafii; Scott T Avecilla; Sergey V Shmelkov; Koji Shido; Rafael Tejada; Malcolm A S Moore; Beate Heissig; Koichi Hattori
Angiogenic factors reconstitute hematopoiesis by recruiting stem cells from bone marrow microenvironment.
Annals of the New York Academy of Sciences 2003;996():49-60.
2003: Koichi Hattori; Beate Heissig; Shahin Rafii
The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1.
Leukemia & lymphoma 2003;44(4):575-82.
2003: Sina Y Rabbany; Beate Heissig; Koichi Hattori; Shahin Rafii
Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization.
Trends in molecular medicine 2003;9(3):109-17.
2003: Zhenping Zhu; Koichi Hattori; Haifan Zhang; Xenia Jimenez; Dale L Ludwig; Sergio Dias; Paul Kussie; Henry Koo; H J Kim; Dan Lu; Meilin Liu; Rafael Tejada; M Friedrich; Peter Bohlen; Larry Witte; Shahin Rafii
Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity.
Leukemia 2003;17(3):604-11.
2003: Beate Heissig; Koichi Hattori; Matthias Friedrich; Shahin Rafii; Zena Werb
Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases.
Current opinion in hematology 2003;10(2):136-41.
2003: Carlos Bais; Albert Van Geelen; Pilar Eroles; Agata Mutlu; Chiara Chiozzini; Sergio Dias; Roy L Silverstein; Shahin Rafii; Enrique Mesri
Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR.
Cancer cell 2003;3(2):131-43.
2003: Shahin Rafii; Mihaela Skobe
Splitting vessels: keeping lymph apart from blood.
Nature medicine 2003;9(2):166-8.
2003: Petri Salven; Satu Mustjoki; Riitta Alitalo; Kari Alitalo; Shahin Rafii
VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells.
Blood 2003;101(1):168-72.
2002: Shahin Rafii
Vaccination against tumor neovascularization: Promise and reality.
Cancer cell 2002;2(6):429-31.
2002: GIUSEPPE PINTUCCI; Scott Froum; Jared Pinnell; Paolo Mignatti; Shahin Rafii; David Green
Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF).
Thrombosis and haemostasis 2002;88(5):834-42.
2002: Shahin Rafii; David Lyden; Robert Benezra; Koichi Hattori; Beate Heissig
Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
Nature reviews. Cancer 2002;2(11):826-35.
2002: Petri Salven; Koichi Hattori; Beate Heissig; Shahin Rafii
Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(11):1471-3.
2002: Koichi Hattori; Beate Heissig; Yan Wu; Sergio Dias; Rafael Tejada; Barbara Ferris; Daniel J Hicklin; Zhenping Zhu; Peter Bohlen; Larry Witte; Jan Hendrikx; Neil R Hackett; Helen-Ann Brown Epstein; Malcolm A S Moore; Zena Werb; David Lyden; Shahin Rafii
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment.
Nature medicine 2002;8(8):841-9.
2002: Errol S Wijelath; Jacqueline Murray; Salman Rahman; Yatin Patel; Atsushi Ishida; Kurt Strand; Salim Aziz; Carlos Cardona; William P Hammond; Geoffrey F Savidge; Shahin Rafii; Michael Sobel
Novel vascular endothelial growth factor binding domains of fibronectin enhance vascular endothelial growth factor biological activity.
Circulation research 2002;91(1):25-31.
2002: Karen L MacKenzie; Sonia Franco; Afzal J Naiyer; Chad May; Michel Sadelain; Shahin Rafii; Malcolm A S Moore
Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras.
Oncogene 2002;21(27):4200-11.
2002: Beate Heissig; Koichi Hattori; Sergio Dias; Matthias Friedrich; Barbara Ferris; Neil R Hackett; Helen-Ann Brown Epstein; Peter Besmer; David Lyden; Malcolm A S Moore; Zena Werb; Shahin Rafii
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.
Cell 2002;109(5):625-37.
2002: Jay M Edelberg; Lilong Tang; Koichi Hattori; David Lyden; Shahin Rafii
Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function.
Circulation research 2002;90(10):E89-93.
2002: Shahin Rafii; B Heissig; K Hattori
Efficient mobilization and recruitment of marrow-derived endothelial and hematopoietic stem cells by adenoviral vectors expressing angiogenic factors.
Gene therapy 2002;9(10):631-41.
2002: Sergio Dias; Sergey V Shmelkov; George Lam; Shahin Rafii
VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition.
Blood 2002;99(7):2532-40.
2002: Sergio Dias; Margaret Choy; Kari Alitalo; Shahin Rafii
Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy.
Blood 2002;99(6):2179-84.
2002: Shahin Rafii; Sarah Meeus; Sergio Dias; Koichi Hattori; Beate Heissig; Sergey V Shmelkov; Daniel Rafii; David Lyden
Contribution of marrow-derived progenitors to vascular and cardiac regeneration.
Seminars in cell & developmental biology 2002;13(1):61-7.
2002: Pierre Feugier; Deog-Yeon Jo; Jae-Hung Shieh; Karen L MacKenzie; Shahin Rafii; Helen-Ann Brown Epstein; Malcolm A S Moore
Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand.
Journal of hematotherapy & stem cell research 2002;11(1):127-38.
2002: Robert Benezra; Paola de-Candia; H Li; E Romero; David Lyden; Shahin Rafii; Marianna B Ruzinova
A genetic approach to understanding tumor angiogenesis.
Cold Spring Harbor symposia on quantitative biology 2002;67():249-54.
2001: Robert Benezra; Shahin Rafii; David Lyden
The Id proteins and angiogenesis.
Oncogene 2001;20(58):8334-41.
2001: William J Lane; K Hattori; Sergio Dias; E I Peerschke; Malcolm A S Moore; D L Blanset; P C Lang; M Petrone; Shahin Rafii
Anagrelide metabolite induces thrombocytopenia in mice by inhibiting megakaryocyte maturation without inducing platelet aggregation.
Experimental hematology 2001;29(12):1417-24.
2001: David Lyden; K Hattori; Sergio Dias; C Costa; Pamela Blaikie; Linda J Butros; Amy Chadburn; Beate Heissig; W Marks; Larry Witte; Y Wu; Daniel J Hicklin; Z Zhu; Neil R Hackett; Helen-Ann Brown Epstein; Malcolm A S Moore; K A Hajjar; Katia Manova-Todorova; Robert Benezra; Shahin Rafii
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth.
Nature medicine 2001;7(11):1194-201.
2001: Sergio Dias; Koichi Hattori; Beate Heissig; Z Zhu; Y Wu; Larry Witte; Daniel J Hicklin; M Tateno; Peter Bohlen; Malcolm A S Moore; Shahin Rafii
Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10857-62.
2001: J Kim; H Wu; L Hawthorne; Shahin Rafii; J Laurence
Endothelial cell apoptotic genes associated with the pathogenesis of thrombotic microangiopathies: an application of oligonucleotide genechip technology.
Microvascular research 2001;62(2):83-93.
2001: Sonia Franco; Karen L MacKenzie; Sergio Dias; S Alvarez; Shahin Rafii; Malcolm A S Moore
Clonal variation in phenotype and life span of human embryonic fibroblasts (MRC-5) transduced with the catalytic component of telomerase (hTERT).
Experimental cell research 2001;268(1):14-25.
2001: Charles J Dimitroff; JY Lee; Shahin Rafii; Robert C Fuhlbrigge; Robert Sackstein
CD44 is a major E-selectin ligand on human hematopoietic progenitor cells.
The Journal of cell biology 2001;153(6):1277-86.
2001: Malcolm A S Moore; K Hattori; Beate Heissig; Jae-Hung Shieh; Sergio Dias; Helen-Ann Brown Epstein; Shahin Rafii
Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-1, VEGF, and angiopoietin-1.
Annals of the New York Academy of Sciences 2001;938():36-45; discussion 45-7.
2001: K Hattori; Beate Heissig; K Tashiro; T Honjo; M Tateno; Jae-Hung Shieh; Neil R Hackett; M S Quitoriano; Helen-Ann Brown Epstein; Shahin Rafii; Malcolm A S Moore
Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells.
Blood 2001;97(11):3354-60.
2001: Shahin Rafii; S Dias; Sarah Meeus; K Hattori; R Ramachandran; F Feuerback; Stefan Worgall; Neil R Hackett; R G Crystal
Infection of endothelium with E1(-)E4(+), but not E1(-)E4(-), adenovirus gene transfer vectors enhances leukocyte adhesion and migration by modulation of ICAM-1, VCAM-1, CD34, and chemokine expression.
Circulation research 2001;88(9):903-10.
2001: K Hattori; Sergio Dias; Beate Heissig; Neil R Hackett; David Lyden; M Tateno; Daniel J Hicklin; Z Zhu; Larry Witte; R G Crystal; Malcolm A S Moore; Shahin Rafii
Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells.
The Journal of experimental medicine 2001;193(9):1005-14.
2001: M Gill; S Dias; K Hattori; M L Rivera; D Hicklin; L Witte; L Girardi; Roger W Yurt; H Himel; Shahin Rafii
Vascular trauma induces rapid but transient mobilization of VEGFR2(+)AC133(+) endothelial precursor cells.
Circulation research 2001;88(2):167-74.
2001: Sergio Dias; Margaret Choy; Shahin Rafii
The role of CXC chemokines in the regulation of tumor angiogenesis.
Cancer investigation 2001;19(7):732-8.
2001: M Choy; Shahin Rafii
Role of angiogenesis in the progression and treatment of prostate cancer.
Cancer investigation 2001;19(2):181-91.
2000: William J Lane; Sergio Dias; K Hattori; Beate Heissig; Margaret Choy; Sina Y Rabbany; J Wood; Malcolm A S Moore; Shahin Rafii
Stromal-derived factor 1-induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases.
Blood 2000;96(13):4152-9.
2000: MJ Donovan; MI Lin; P Wiegn; T Ringstedt; R Kraemer; R Hahn; S Wang; C F Ibañez; Shahin Rafii; Barbara L Hempstead
Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization.
Development (Cambridge, England) 2000;127(21):4531-40.
2000: R Ramalingam; Stefan Worgall; Shahin Rafii; Helen-Ann Brown Epstein
Downregulation of CXCR4 gene expression in primary human endothelial cells following infection with E1(-)E4(+) adenovirus gene transfer vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(4):381-6.
2000: Gail J Roboz; Sergio Dias; G Lam; William J Lane; Steven L Soignet; RP Warrell; Shahin Rafii
Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis.
Blood 2000;96(4):1525-30.
2000: Sergio Dias; K Hattori; Z Zhu; Beate Heissig; Margaret Choy; William Stratton Lane; Y Wu; Amy Chadburn; Elizabeth Hyjek; M Gill; Daniel J Hicklin; Larry Witte; Malcolm A S Moore; Shahin Rafii
Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration.
The Journal of clinical investigation 2000;106(4):511-21.
2000: F Bautz; Shahin Rafii; Lothar Kanz; Robert Möhle
Expression and secretion of vascular endothelial growth factor-A by cytokine-stimulated hematopoietic progenitor cells. Possible role in the hematopoietic microenvironment.
Experimental hematology 2000;28(6):700-6.
2000: M Peichev; A J Naiyer; D Pereira; Z Zhu; William J Lane; M Williams; Mehmet C Oz; Daniel J Hicklin; Larry Witte; Malcolm A S Moore; Shahin Rafii
Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors.
Blood 2000;95(3):952-8.
2000: D Y Jo; Shahin Rafii; T Hamada; Malcolm A S Moore
Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1.
The Journal of clinical investigation 2000;105(1):101-11.
2000: Shahin Rafii
Circulating endothelial precursors: mystery, reality, and promise.
The Journal of clinical investigation 2000;105(1):17-9.
1999: A J Naiyer; D Y Jo; J Ahn; R Mohle; M Peichev; G Lam; R L Silverstein; Malcolm A S Moore; Shahin Rafii
Stromal derived factor-1-induced chemokinesis of cord blood CD34(+) cells (long-term culture-initiating cells) through endothelial cells is mediated by E-selectin.
Blood 1999;94(12):4011-9.
1999: R Ramalingam; Shahin Rafii; Stefan Worgall; Neil R Hackett; Helen-Ann Brown Epstein
Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer vector.
Journal of virology 1999;73(12):10183-90.
1999: Caroline Leventhal; Shahin Rafii; D Rafii; A Shahar; Steven Goldman
Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma.
Molecular and cellular neurosciences 1999;13(6):450-64.
1999: G J Roboz; Shahin Rafii
Interleukin-5 and the regulation of eosinophil production.
Current opinion in hematology 1999;6(3):164-8.
1999: R Ramalingam; Shahin Rafii; Stefan Worgall; D E Brough; Helen-Ann Brown Epstein
E1(-)E4(+) adenoviral gene transfer vectors function as a "pro-life" signal to promote survival of primary human endothelial cells.
Blood 1999;93(9):2936-44.
1999: Robert Möhle; F Bautz; Shahin Rafii; Malcolm A S Moore; Wolfram Brugger; Lothar Kanz
Regulation of transendothelial migration of hematopoietic progenitor cells.
Annals of the New York Academy of Sciences 1999;872():176-85; discussion 185-6.
1999: Edward L Hannan; M van Ryn; J Burke; D Stone; D Kumar; DT Arani; W Pierce; Shahin Rafii; T A Sanborn; S Sharma; J Slater; BA DeBuono
Access to coronary artery bypass surgery by race/ethnicity and gender among patients who are appropriate for surgery.
Medical care 1999;37(1):68-77.
1998: B M Frey; Shahin Rafii; Helen-Ann Brown Epstein; Malcolm A S Moore
[Adenovirus long-term expression of thrombopoietin in vivo: a new model for myeloproliferative syndrome and osteomyelofibrosis].
Schweizerische medizinische Wochenschrift 1998;128(42):1587-92.
1998: Ornella Flore; Shahin Rafii; Scott Ely; John J O'Leary; Elizabeth Hyjek; Ethel Cesarman
Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus.
Nature 1998;394(6693):588-92.
1998: T Hamada; R Möhle; Joseph Hesselgesser; James A Hoxie; RL Nachman; Malcolm A S Moore; Shahin Rafii
Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation.
The Journal of experimental medicine 1998;188(3):539-48.
1998: Qun Shi; Shahin Rafii; MH Wu; Errol S Wijelath; C Yu; Atsushi Ishida; Y Fujita; S Kothari; R Mohle; Lester R Sauvage; Malcolm A S Moore; R F Storb; William P Hammond
Evidence for circulating bone marrow-derived endothelial cells.
Blood 1998;92(2):362-7.
1998: Robert Möhle; F Bautz; Shahin Rafii; Malcolm A S Moore; Wolfram Brugger; Lothar Kanz
The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1.
Blood 1998;91(12):4523-30.
1998: B M Frey; Neil R Hackett; J M Bergelson; R Finberg; Helen-Ann Brown Epstein; Malcolm A S Moore; Shahin Rafii
High-efficiency gene transfer into ex vivo expanded human hematopoietic progenitors and precursor cells by adenovirus vectors.
Blood 1998;91(8):2781-92.
1998: B M Frey; Shahin Rafii; M Teterson; D Eaton; Helen-Ann Brown Epstein; Malcolm A S Moore
Adenovector-mediated expression of human thrombopoietin cDNA in immune-compromised mice: insights into the pathophysiology of osteomyelofibrosis.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):691-9.
1998: R Möhle; Shahin Rafii; Malcolm A S Moore
The role of endothelium in the regulation of hematopoietic stem cell migration.
Stem cells (Dayton, Ohio) 1998;16 Suppl 1():159-65.
1997: R Möhle; P Salemi; Malcolm A S Moore; Shahin Rafii
Expression of interleukin-5 by human bone marrow microvascular endothelial cells: implications for the regulation of eosinophilopoiesis in vivo.
British journal of haematology 1997;99(4):732-8.
1997: Shahin Rafii; R Mohle; F Shapiro; B M Frey; Malcolm A S Moore
Regulation of hematopoiesis by microvascular endothelium.
Leukemia & lymphoma 1997;27(5-6):375-86.
1997: W Song; HL Kong; H Carpenter; H Torii; Richard D Granstein; Shahin Rafii; Malcolm A S Moore; Helen-Ann Brown Epstein
Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity.
The Journal of experimental medicine 1997;186(8):1247-56.
1997: R Möhle; D Green; Malcolm A S Moore; RL Nachman; Shahin Rafii
Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):663-8.
1997: R Möhle; Malcolm A S Moore; RL Nachman; Shahin Rafii
Transendothelial migration of CD34+ and mature hematopoietic cells: an in vitro study using a human bone marrow endothelial cell line.
Blood 1997;89(1):72-80.
1996: F Shapiro; Bronislaw Pytowski; Shahin Rafii; Larry Witte; D J Hicklin; Tzy-Jyun Yao; Malcolm A S Moore
The effects of Flk-2/flt3 ligand as compared with c-kit ligand on short-term and long-term proliferation of CD34+ hematopoietic progenitors elicited from human fetal liver, umbilical cord blood, bone marrow, and mobilized peripheral blood.
Journal of hematotherapy 1996;5(6):655-62.
1996: F J Candal; Shahin Rafii; J T Parker; Edwin W Ades; B Ferris; R L Nachman; K L Kellar
BMEC-1: a human bone marrow microvascular endothelial cell line with primary cell characteristics.
Microvascular research 1996;52(3):221-34.
1996: A Ohwada; Shahin Rafii; Malcolm A S Moore; Helen-Ann Brown Epstein
In vivo adenovirus vector-mediated transfer of the human thrombopoietin cDNA maintains platelet levels during radiation-and chemotherapy-induced bone marrow suppression.
Blood 1996;88(3):778-84.
1996: Enrique Mesri; Ethel Cesarman; L Arvanitakis; Shahin Rafii; Malcolm A S Moore; David N Posnett; Daniel M Knowles; A S Asch
Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells.
The Journal of experimental medicine 1996;183(5):2385-90.
1996: S V Yurasov; M Flasshove; Shahin Rafii; Malcolm A S Moore
Density enrichment and characterization of hematopoietic progenitors and stem cells from umbilical cord blood.
Bone marrow transplantation 1996;17(4):517-25.
1995: Shahin Rafii; Mehmet C Oz; JA Seldomridge; B Ferris; A S Asch; R L Nachman; F Shapiro; Eric A Rose; HR Levin
Characterization of hematopoietic cells arising on the textured surface of left ventricular assist devices.
The Annals of thoracic surgery 1995;60(6):1627-32.
1995: Shahin Rafii; F Shapiro; R Pettengell; B Ferris; R L Nachman; Malcolm A S Moore; A S Asch
Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors.
Blood 1995;86(9):3353-63.
1994: Shahin Rafii; F Shapiro; J Rimarachin; R L Nachman; B Ferris; B Weksler; Malcolm A S Moore; A S Asch
Isolation and characterization of human bone marrow microvascular endothelial cells: hematopoietic progenitor cell adhesion.
Blood 1994;84(1):10-9.
1992: C C Liu; Shahin Rafii; H Koizumi; Angela Granelli-Piperno; J D Young
Perforin gene expression in stimulated human peripheral blood T cells studied by in situ hybridization and northern blotting analysis.
Immunology letters 1992;33(1):79-85.
1990: L H Young; C C Liu; S Joag; Shahin Rafii; J D Young
How lymphocytes kill.
Annual review of medicine 1990;41():45-54.
1989: C C Liu; Shahin Rafii; Angela Granelli-Piperno; J A Trapani; J D Young
Perforin and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A.
The Journal of experimental medicine 1989;170(6):2105-18.
1989: S Wadler; K Tai; L R Chervu; Shahin Rafii; L Landau; M Donald Blaufox; P H Wiernik
Iodine-131 MIBG scintigraphy in small cell lung cancer.
European journal of nuclear medicine 1989;15(2):108-10.