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David Ragsdale

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TOP 3
David S Ragsdale
How do mutant Nav1.1 sodium channels cause epilepsy?
Daniela Merlo; Cristiana Mollinari; Yuji Inaba; A Cardinale; A M Rinaldi; Margherita D'Antuono; Giovanna D'Arcangelo; Virginia Tancredi; David S Ragsdale; Massimo Avoli
Reduced GABAB receptor subunit expression and paired-pulse depression in a genetic model of absence seizures.
Paul T Lucas; Laurence S Meadows; Jane Nicholls; David S Ragsdale
An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin.

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All Publications

2008: David S Ragsdale
How do mutant Nav1.1 sodium channels cause epilepsy?
Brain research reviews 2008;58(1):149-59.
2007: Daniela Merlo; Cristiana Mollinari; Yuji Inaba; A Cardinale; A M Rinaldi; Margherita D'Antuono; Giovanna D'Arcangelo; Virginia Tancredi; David S Ragsdale; Massimo Avoli
Reduced GABAB receptor subunit expression and paired-pulse depression in a genetic model of absence seizures.
Neurobiology of disease 2007;25(3):631-41.
2005: Paul T Lucas; Laurence S Meadows; Jane Nicholls; David S Ragsdale
An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin.
Epilepsy research 2005;64(3):77-84.
2003: Newton Agrawal; Angel Alonso; David S Ragsdale
Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy.
Epilepsia 2003;44(12):1601-4.
2003: Jacopo Magistretti; David S Ragsdale; Angel Alonso
Kinetic diversity of single-channel burst openings underlying persistent Na(+) current in entorhinal cortex neurons.
Biophysical journal 2003;85(5):3019-34.
2003: Lyn De Leon; David S Ragsdale
State-dependent access to the batrachotoxin receptor on the sodium channel.
Neuroreport 2003;14(10):1353-6.
2003: Patrick Cossette; Andrew Loukas; Ronald G Lafrenière; Daniel Rochefort; Erik Harvey-Girard; David S Ragsdale; Robert J Dunn; Guy Rouleau
Functional characterization of the D188V mutation in neuronal voltage-gated sodium channel causing generalized epilepsy with febrile seizures plus (GEFS).
Epilepsy research 2003;53(1-2):107-17.
2002: Laurence S Meadows; Jyoti D Malhotra; Andrew Loukas; Veena Thyagarajan; Kristin A Kazen-Gillespie; Matthew C Koopman; Steven Kriegler; Lori L Isom; David S Ragsdale
Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(24):10699-709.
2002: Hong-Ling Li; David Hadid; David S Ragsdale
The batrachotoxin receptor on the voltage-gated sodium channel is guarded by the channel activation gate.
Molecular pharmacology 2002;61(4):905-12.
2002: Laurence S Meadows; Y H Chen; A J Powell; Jeffrey J Clare; David S Ragsdale
Functional modulation of human brain Nav1.3 sodium channels, expressed in mammalian cells, by auxiliary beta 1, beta 2 and beta 3 subunits.
Neuroscience 2002;114(3):745-53.
2001: Laurence S Meadows; Jyoti D Malhotra; A Stetzer; Lori L Isom; David S Ragsdale
The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit.
Journal of neurochemistry 2001;76(6):1871-8.
2001: N Agrawal; Bassam N Hamam; Jacopo Magistretti; Angel A Alonso; David S Ragsdale
Persistent sodium channel activity mediates subthreshold membrane potential oscillations and low-threshold spikes in rat entorhinal cortex layer V neurons.
Neuroscience 2001;102(1):53-64.
2000: Kristin A Kazen-Gillespie; David S Ragsdale; M R D'Andrea; LN Mattei; K E Rogers; Lori L Isom
Cloning, localization, and functional expression of sodium channel beta1A subunits.
The Journal of biological chemistry 2000;275(2):1079-88.
1999: Jacopo Magistretti; David S Ragsdale; Angel A Alonso
Direct demonstration of persistent Na+ channel activity in dendritic processes of mammalian cortical neurones.
The Journal of physiology 1999;521 Pt 3():629-36.
1999: Zhi-Cheng Xiao; David S Ragsdale; Jyoti D Malhotra; LN Mattei; Peter E Braun; M Schachner; Lori L Isom
Tenascin-R is a functional modulator of sodium channel beta subunits.
The Journal of biological chemistry 1999;274(37):26511-7.
1999: Jacopo Magistretti; David S Ragsdale; Angel A Alonso
High conductance sustained single-channel activity responsible for the low-threshold persistent Na(+) current in entorhinal cortex neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(17):7334-41.
1999: H L Li; A Galue; Laurence S Meadows; David S Ragsdale
A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel.
Molecular pharmacology 1999;55(1):134-41.
1998: David S Ragsdale; Massimo Avoli
Sodium channels as molecular targets for antiepileptic drugs.
Brain research. Brain research reviews 1998;26(1):16-28.
1998: KA McCormick; Lori L Isom; David S Ragsdale; D Smith; Todd Scheuer; William A Catterall
Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit.
The Journal of biological chemistry 1998;273(7):3954-62.
1998: J C McPhee; David S Ragsdale; Todd Scheuer; William A Catterall
A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel alpha-subunit in fast inactivation.
The Journal of biological chemistry 1998;273(2):1121-9.
1996: David S Ragsdale; J C McPhee; Todd Scheuer; William A Catterall
Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9270-5.
1995: Lori L Isom; David S Ragsdale; K S De Jongh; Ruth E Westenbroek; B F Reber; Todd Scheuer; William A Catterall
Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif.
Cell 1995;83(3):433-42.
1995: J C McPhee; David S Ragsdale; Todd Scheuer; William A Catterall
A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation.
The Journal of biological chemistry 1995;270(20):12025-34.
1995: Lori L Isom; Todd Scheuer; A B Brownstein; David S Ragsdale; Brian J Murphy; William A Catterall
Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line.
The Journal of biological chemistry 1995;270(7):3306-12.
1994: J C McPhee; David S Ragsdale; Todd Scheuer; William A Catterall
A mutation in segment IVS6 disrupts fast inactivation of sodium channels.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12346-50.
1994: David S Ragsdale; J C McPhee; Todd Scheuer; William A Catterall
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
Science (New York, N.Y.) 1994;265(5179):1724-8.
1993: David S Ragsdale; R Numann; William A Catterall; Todd Scheuer
Inhibition of Na+ channels by the novel blocker PD85,639.
Molecular pharmacology 1993;43(6):949-54.
1991: David S Ragsdale; Todd Scheuer; William A Catterall
Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs.
Molecular pharmacology 1991;40(5):756-65.