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Jens-Ulrich Rahfeld

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Procedures

Living Beings

Legionella pneumophila

Phenomena

Protein Binding

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Publications

TOP 3
Petr Kolenko; Jens-Ulrich Rahfeld; Stephan Schilling; Hans Ulrich Demuth; Birgit Koch; Milton T Stubbs
Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4.
Birgit Koch; Petr Kolenko; Christoph Parthier; Jens-Ulrich Rahfeld; Gunter Reuter; Stephan Schilling; Milton T Stubbs; Michael Wermann; David Ruiz Carrillo; Mirko Buchholz; Hans-Ulrich Demuth
Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs.
Holger Cynis; Margreet R De Vries; Sabine Berg; Rico Eichentopf; Ernst-Joachim Freyse; Daniel Friedrich; Kathrin Gans; Sigrid Graubner; Monique Haegele; Ulrich Heiser; Isabel Hesse; Torsten Hoffmann; Wolfgang Jagla; Astrid Kehlen; Martin Kleinschmidt; Anke Müller; Paul H A Quax; Jens-Ulrich Rahfeld; Stephan Schilling; Reinhard Sedlmeier; Franziska Seifert; Anett Stephan; Daniela Trautwein; Michael Wermann; Raik Wolf; Ulrich Wollert; Hans-Ulrich Demuth
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.

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All Publications

2013: Petr Kolenko; Jens-Ulrich Rahfeld; Stephan Schilling; Hans Ulrich Demuth; Birgit Koch; Milton T Stubbs
Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4.
Acta crystallographica. Section F, Structural biology and crystallization communications 2013;69(Pt 4):358-61.
2012: Birgit Koch; Petr Kolenko; Christoph Parthier; Jens-Ulrich Rahfeld; Gunter Reuter; Stephan Schilling; Milton T Stubbs; Michael Wermann; David Ruiz Carrillo; Mirko Buchholz; Hans-Ulrich Demuth
Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs.
Biochemistry 2012;51(37):7383-92.
2011: Holger Cynis; Margreet R De Vries; Sabine Berg; Rico Eichentopf; Ernst-Joachim Freyse; Daniel Friedrich; Kathrin Gans; Sigrid Graubner; Monique Haegele; Ulrich Heiser; Isabel Hesse; Torsten Hoffmann; Wolfgang Jagla; Astrid Kehlen; Martin Kleinschmidt; Anke Müller; Paul H A Quax; Jens-Ulrich Rahfeld; Stephan Schilling; Reinhard Sedlmeier; Franziska Seifert; Anett Stephan; Daniela Trautwein; Michael Wermann; Raik Wolf; Ulrich Wollert; Hans-Ulrich Demuth
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
EMBO molecular medicine 2011;3(9):545-58.
2011: David Ruiz-Carrillo; Stephan Schilling; Milton T Stubbs; Michael Wermann; Ulrich Heiser; Birgit Koch; Hans-Henning Ludwig; Christoph Parthier; Jens-Ulrich Rahfeld; Mirko Buchholz; Tresfore Dambe; Hans-Ulrich Demuth
Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.
Biochemistry 2011;50(28):6280-8.
2011: Leona Wagner; Michael Wermann; Torsten Hoffmann; Jens-Ulrich Rahfeld; Fred Rosche; Hans-Ulrich Demuth
Isolation of dipeptidyl peptidase IV (DP 4) isoforms from porcine kidney by preparative isoelectric focusing to improve crystallization.
Biological chemistry 2011;392(7):665-77.
2011: Kerstin Kühn-Wache; Joachim W Bär; Torsten Hoffmann; Raik Wolf; Jens-Ulrich Rahfeld; Hans-Ulrich Demuth
Selective inhibition of dipeptidyl peptidase 4 by targeting a substrate-specific secondary binding site.
Biological chemistry 2011;392(3):223-31.
2010: David Ruiz Carrillo; Christoph Parthier; Nadine Jänckel; Julia Grandke; Marco Stelter; Stephan Schilling; Mathias Boehme; Piotr Neumann; Raik Wolf; Hans-Ulrich Demuth; Milton T Stubbs; Jens-Ulrich Rahfeld
Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus.
Biological chemistry 2010;391(12):1419-28.
2008: Holger Cynis; Jens-Ulrich Rahfeld; Anett Stephan; Astrid Kehlen; Birgit Koch; Michael Wermann; Hans-Ulrich Demuth; Stephan Schilling
Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.
Journal of molecular biology 2008;379(5):966-80.
2007: Stephan Schilling; Christiane Lindner; Birgit Koch; Michael Wermann; Jens-Ulrich Rahfeld; Alex von Bohlen; Thomas Rudolph; Gunter Reuter; Hans-Ulrich Demuth
Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.
Biochemistry 2007;46(38):10921-30.
2007: Christoph Parthier; Martin Kleinschmidt; Piotr Neumann; Rainer Rudolph; Susanne Manhart; Dagmar Schlenzig; Jörg Fanghänel; Jens-Ulrich Rahfeld; Hans-Ulrich Demuth; Milton T Stubbs
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):13942-7.
2007: Nadine Frerker; Leona Wagner; Raik Wolf; Ulrich Heiser; Torsten Hoffmann; Jens-Ulrich Rahfeld; Jutta Schade; Tim Karl; Hassan Y Naim; Marwan Alfalah; Hans-Ulrich Demuth; Stephan von Hörsten
Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4.
Peptides 2007;28(2):257-68.
2006: Leona Wagner; Torsten Hoffmann; Jens-Ulrich Rahfeld; Hans-Ulrich Demuth
Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR.
Advances in experimental medicine and biology 2006;575():109-16.
2006: Joachim Bär; Jens-Ulrich Rahfeld; Ingo Schulz; Kathrin Gans; David Ruiz-Carrillo; Susanne Manhart; Fred Rosche; Hans-Ulrich Demuth
Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits an unknown post-cysteine cleavage specificity.
Advances in experimental medicine and biology 2006;575():103-8.
2005: Ingo Schulz; Ulrike Zeitschel; Thomas Rudolph; David Ruiz-Carrillo; Jens-Ulrich Rahfeld; Bernd Gerhartz; Volker Bigl; Hans-Ulrich Demuth; Steffen Rossner
Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion.
Journal of neurochemistry 2005;94(4):970-9.
2005: Frank Edlich; Matthias Weiwad; Frank Erdmann; Jörg Fanghänel; Franziska Jarczowski; Jens-Ulrich Rahfeld; Gunter Fischer
Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin.
The EMBO journal 2005;24(14):2688-99.
2004: Angelika Kühlewein; Georg Voll; Birte Hernandez Alvarez; Horst Kessler; Gunter Fischer; Jens-Ulrich Rahfeld; Gerd Gemmecker
Solution structure of Escherichia coli Par10: The prototypic member of the Parvulin family of peptidyl-prolyl cis/trans isomerases.
Protein science : a publication of the Protein Society 2004;13(9):2378-87.
2003: Stephan Schilling; André J Niestroj; Jens-Ulrich Rahfeld; Torsten Hoffmann; Michael Wermann; Katrin Zunkel; Claus Wasternack; Hans-Ulrich Demuth
Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators.
The Journal of biological chemistry 2003;278(50):49773-9.
2003: Rolf Köhler; Jörg Fanghänel; Bettina König; Edeltraud Lüneberg; Matthias Frosch; Jens-Ulrich Rahfeld; Rolf Hilgenfeld; Gunter Fischer; Jörg Hacker; Michael Steinert
Biochemical and functional analyses of the Mip protein: influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella pneumophila.
Infection and immunity 2003;71(8):4389-97.
2003: Tatiana Reimer; Matthias Weiwad; Angelika Schierhorn; Peter-Karl Ruecknagel; Jens-Ulrich Rahfeld; Peter Bayer; Gunter Fischer
Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14.
Journal of molecular biology 2003;330(5):955-66.
2002: Thilo Kamphausen; Jörg Fanghänel; Dieter Neumann; Burkhard Schulz; Jens-Ulrich Rahfeld
Characterization of Arabidopsis thaliana AtFKBP42 that is membrane-bound and interacts with Hsp90.
The Plant journal : for cell and molecular biology 2002;32(3):263-76.
2002: Tatiana Anna Surmacz; Elena Bayer; Jens-Ulrich Rahfeld; Gunter Fischer; Peter Bayer
The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding.
Journal of molecular biology 2002;321(2):235-47.
2001: Alan Riboldi-Tunnicliffe; Bettina König; S Jessen; Manfred S Weiss; Jens-Ulrich Rahfeld; Jörg Hacker; G Fischer; Rolf Hilgenfeld
Crystal structure of Mip, a prolylisomerase from Legionella pneumophila.
Nature structural biology 2001;8(9):779-83.
2000: E Sekerina; Jens-Ulrich Rahfeld; J Müller; Jörg Fanghänel; C Rascher; Gunter Fischer; Peter Bayer
NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein.
Journal of molecular biology 2000;301(4):1003-17.
1999: T Uchida; F Fujimori; T Tradler; Gunter Fischer; Jens-Ulrich Rahfeld
Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase.
FEBS letters 1999;446(2-3):278-82.
1997: T Tradler; Gerlind Stoller; Karl Peter Rücknagel; Angelika Schierhorn; Jens-Ulrich Rahfeld; Gunter Fischer
Comparative mutational analysis of peptidyl prolyl cis/trans isomerases: active sites of Escherichia coli trigger factor and human FKBP12.
FEBS letters 1997;407(2):184-90.
1996: Jens-Ulrich Rahfeld; Karl Peter Rücknagel; Gerlind Stoller; Shelley M Horne; Angelika Schierhorn; Kevin D Young; Gunter Fischer
Isolation and amino acid sequence of a new 22-kDa FKBP-like peptidyl-prolyl cis/trans-isomerase of Escherichia coli. Similarity to Mip-like proteins of pathogenic bacteria.
The Journal of biological chemistry 1996;271(36):22130-8.
1996: B Schmidt; T Tradler; Jens-Ulrich Rahfeld; B Ludwig; B Jain; K Mann; Karl Peter Rücknagel; B Janowski; Angelika Schierhorn; Gerd Küllertz; J Hacker; Gunter Fischer
A cyclophilin-like peptidyl-prolyl cis/trans isomerase from Legionella pneumophila--characterization, molecular cloning and overexpression.
Molecular microbiology 1996;21(6):1147-60.
1995: Wolfgang Brandt; T Lehmann; I Thondorf; I Born; Mike Schutkowski; Jens-Ulrich Rahfeld; Klaus Neubert; A Barth
A model of the active site of dipeptidyl peptidase IV predicted by comparative molecular field analysis and molecular modelling simulations.
International journal of peptide and protein research 1995;46(6):494-507.
1995: Gerlind Stoller; Karl Peter Rücknagel; K H Nierhaus; Franz X Schmid; Gunter Fischer; Jens-Ulrich Rahfeld
A ribosome-associated peptidyl-prolyl cis/trans isomerase identified as the trigger factor.
The EMBO journal 1995;14(20):4939-48.
1994: Jens-Ulrich Rahfeld; Karl Peter Rücknagel; B Schelbert; B Ludwig; J Hacker; K Mann; Gunter Fischer
Confirmation of the existence of a third family among peptidyl-prolyl cis/trans isomerases. Amino acid sequence and recombinant production of parvulin.
FEBS letters 1994;352(2):180-4.
1994: B Schmidt; Jens-Ulrich Rahfeld; Angelika Schierhorn; B Ludwig; J Hacker; Gunter Fischer
A homodimer represents an active species of the peptidyl-prolyl cis/trans isomerase FKBP25mem from Legionella pneumophila.
FEBS letters 1994;352(2):185-90.
1994: Jens-Ulrich Rahfeld; Angelika Schierhorn; K Mann; Gunter Fischer
A novel peptidyl-prolyl cis/trans isomerase from Escherichia coli.
FEBS letters 1994;343(1):65-9.
1991: Jens-Ulrich Rahfeld; Mike Schutkowski; J Faust; Klaus Neubert; A Barth; J Heins
Extended investigation of the substrate specificity of dipeptidyl peptidase IV from pig kidney.
Biological chemistry Hoppe-Seyler 1991;372(5):313-8.
1991: Jens-Ulrich Rahfeld; M Schierhorn; Bianka Hartrodt; Klaus Neubert; J Heins
Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV?
Biochimica et biophysica acta 1991;1076(2):314-6.