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Irfan Rahman

Research Profile

Disorders

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Publications

TOP 3
Isaac Kirubakaran Sundar; Hongwei Yao; Irfan Rahman
Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases.
Irfan Rahman
Retraction: cigarette smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid shear stress-mediated signaling in endothelial cells. Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, and Rahman I. Antioxid Redox Signal 12: 1355-1369, 2010.
S Biswas; J W Hwang; P A Kirkham; Irfan Rahman
Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease.

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All Publications

2013: Isaac Kirubakaran Sundar; Hongwei Yao; Irfan Rahman
Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases.
Antioxidants & redox signaling 2013;18(15):1956-71.
2013: Irfan Rahman
Retraction: cigarette smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid shear stress-mediated signaling in endothelial cells. Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, and Rahman I. Antioxid Redox Signal 12: 1355-1369, 2010.
Antioxidants & redox signaling 2013;18(12):1535.
2013: S Biswas; J W Hwang; P A Kirkham; Irfan Rahman
Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease.
Current medicinal chemistry 2013;20(12):1496-530.
2012: Hongwei Yao; Irfan Rahman
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
Biochemical pharmacology 2012;84(10):1332-9.
2012: Hongwei Yao; Irfan Rahman
Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD.
American journal of physiology. Lung cellular and molecular physiology 2012;303(7):L557-66.
2012: Irfan Rahman; William MacNee
Antioxidant pharmacological therapies for COPD.
Current opinion in pharmacology 2012;12(3):256-65.
2012: Irfan Rahman; Vuokko L Kinnula
Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease.
Expert review of clinical pharmacology 2012;5(3):293-309.
2012: Irfan Rahman; Vera Gorbunova; Vuokko L Kinnula; Hongwei Yao
SIRT1 as a therapeutic target in inflammaging of the pulmonary disease.
Preventive medicine 2012;54 Suppl():S20-8.
2012: Isaac Kirubakaran Sundar; Hongwei Yao; Michael Bulger; Sangwoon Chung; James R Davie; Alan E Friedman; Jae-Woong Hwang; John D Lapek; Irfan Rahman
Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes.
PloS one 2012;7(2):e31378.
2011: Sergiy M Nadtochiy; Irfan Rahman; Hongwei Yao; Wei Gu; Leonard Guarente; Michael W McBurney; Paul S Brookes
SIRT1-mediated acute cardioprotection.
American journal of physiology. Heart and circulatory physiology 2011;301(4):H1506-12.
2011: Jae-woong Hwang; Vuokko L Kinnula; Gloria Pryhuber; Sangwoon Chung; Heidie L Huyck; Saravanan Rajendrasozhan; Isaac Kirubakaran Sundar; Hongwei Yao; Irfan Rahman
FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(2):987-98.
2011: Isaac Kirubakaran Sundar; Jae-Woong Hwang; Shaoping Wu; Jun Sun; Irfan Rahman
Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation.
Biochemical and biophysical research communications 2011;406(1):127-33.
2011: Sergiy M Nadtochiy; Emily Redman; Irfan Rahman; Paul S Brookes
Lysine deacetylation in ischaemic preconditioning: the role of SIRT1.
Cardiovascular research 2011;89(3):643-9.
2011: Isaac Kirubakaran Sundar; Irfan Rahman
Vitamin d and susceptibility of chronic lung diseases: role of epigenetics.
Frontiers in pharmacology 2011;2():50.
2011: Sangwoon Chung; Jae-Woong Hwang; Vuokko L Kinnula; Timothy S Blackwell; Michael Bulger; Isaac Kirubakaran Sundar; Hongwei Yao; Fiona E Yull; Irfan Rahman
NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.
PloS one 2011;6(8):e23488.
2010: David Adenuga; Samuel Caito; Hongwei Yao; Isaac Kirubakaran Sundar; Jae-Woong Hwang; Sangwoon Chung; Irfan Rahman
Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction.
Biochemical and biophysical research communications 2010;403(3-4):452-6.
2010: Sangwoon Chung; Hongwei Yao; Samuel Caito; Jae-Woong Hwang; Gnanapragasam Arunachalam; Irfan Rahman
Regulation of SIRT1 in cellular functions: role of polyphenols.
Archives of biochemistry and biophysics 2010;501(1):79-90.
2010: Samuel Caito; Saravanan Rajendrasozhan; Suzanne Cook; Sangwoon Chung; Hongwei Yao; Alan E Friedman; Paul S Brookes; Irfan Rahman
SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(9):3145-59.
2010: Hongwei Yao; Gnanapragasam Arunachalam; Jae-Woong Hwang; Sangwoon Chung; Isaac Kirubakaran Sundar; Vuokko L Kinnula; James D Crapo; Irfan Rahman
Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(35):15571-6.
2010: Jae-woong Hwang; Sangwoon Chung; Isaac Kirubakaran Sundar; Hongwei Yao; Gnanapragasam Arunachalam; Michael W McBurney; Irfan Rahman
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD.
Archives of biochemistry and biophysics 2010;500(2):203-9.
2010: Sangwoon Chung; Isaac Kirubakaran Sundar; Hongwei Yao; Ye-Shih Ho; Irfan Rahman
Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation.
American journal of physiology. Lung cellular and molecular physiology 2010;299(2):L192-203.
2010: Indika Edirisinghe; Gnanapragasam Arunachalam; Chelsea Wong; Hongwei Yao; Arshad Rahman; Richard P Phipps; Zheng-Gen Jin; Irfan Rahman
Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells.
Antioxidants & redox signaling 2010;12(12):1355-69.
2010: David Adenuga; Irfan Rahman
Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes.
Archives of biochemistry and biophysics 2010;498(1):62-73.
2010: Saravanan Rajendrasozhan; Jae-Woong Hwang; Hongwei Yao; Nandini Kishore; Irfan Rahman
Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke.
Pulmonary pharmacology & therapeutics 2010;23(3):172-81.
2010: Gnanapragasam Arunachalam; Hongwei Yao; Isaac Kirubakaran Sundar; Samuel Caito; Irfan Rahman
SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol.
Biochemical and biophysical research communications 2010;393(1):66-72.
2010: Hongwei Yao; Jae-woong Hwang; Jorge Moscat; Maria T Diaz-Meco; Michael Leitges; Nandini Kishore; Xiong Li; Irfan Rahman
Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications.
The Journal of biological chemistry 2010;285(8):5405-16.
2010: Samuel Caito; Jae-Woong Hwang; Sangwoon Chung; Hongwei Yao; Isaac Kirubakaran Sundar; Irfan Rahman
PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity.
Biochemical and biophysical research communications 2010;392(3):264-70.
2010: Saravanan Rajendrasozhan; Sangwoon Chung; Isaac Kirubakaran Sundar; Hongwei Yao; Irfan Rahman
Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling.
American journal of physiology. Lung cellular and molecular physiology 2010;298(2):L197-209.
2010: Irfan Rahman; Sangwoon Chung
Dietary polyphenols, deacetylases and chromatin remodeling in inflammation.
Journal of nutrigenetics and nutrigenomics 2010;3(4-6):220-30.
2010: Gnanapragasam Arunachalam; Isaac Kirubakaran Sundar; Jae-Woong Hwang; Hongwei Yao; Irfan Rahman
Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD.
Journal of inflammation (London, England) 2010;7():34.
2010: Isaac Kirubakaran Sundar; Samuel Caito; Hongwei Yao; Irfan Rahman
Oxidative stress, thiol redox signaling methods in epigenetics.
Methods in enzymology 2010;474():213-44.
2010: Irfan Rahman; Sangwoon Chung
Dietary polyphenols, deacetylases and chromatin remodeling in inflammation.
World review of nutrition and dietetics 2010;101():84-94.
2010: Simona Bancos; Carolyn J Baglole; Irfan Rahman; Richard P Phipps
Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2.
Cellular immunology 2010;262(1):18-27.
2009: Saravanan Rajendrasozhan; Hongwei Yao; Irfan Rahman
Current perspectives on role of chromatin modifications and deacetylases in lung inflammation in COPD.
COPD 2009;6(4):291-7.
2009: Hongwei Yao; Irfan Rahman
Current concepts on the role of inflammation in COPD and lung cancer.
Current opinion in pharmacology 2009;9(4):375-83.
2009: David Adenuga; Hongwei Yao; Thomas H March; JeanClare Seagrave; Irfan Rahman
Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke.
American journal of respiratory cell and molecular biology 2009;40(4):464-73.
2009: Saibal K Biswas; Irfan Rahman
Environmental toxicity, redox signaling and lung inflammation: the role of glutathione.
Molecular aspects of medicine 2009;30(1-2):60-76.
2009: Se-Ran Yang; Hongwei Yao; Saravanan Rajendrasozhan; Sangwoon Chung; Indika Edirisinghe; Samantha Valvo; George Fromm; Michael J McCabe; Patricia J Sime; Richard P Phipps; Jian-Dong Li; Michael Bulger; Irfan Rahman
RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke.
American journal of respiratory cell and molecular biology 2009;40(2):147-58.
2008: Irfan Rahman
Antioxidant therapeutic advances in COPD.
Therapeutic advances in respiratory disease 2008;2(6):351-74.
2008: koremu meja; Saravanan Rajendrasozhan; David Adenuga; Saibal K Biswas; Isaac Kirubakaran Sundar; Gillian Spooner; John A Marwick; Probir Chakravarty; Danielle Fletcher; Paul Whittaker; Ian L Megson; Paul A Kirkham; Irfan Rahman
Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2.
American journal of respiratory cell and molecular biology 2008;39(3):312-23.
2008: Saibal Biswas; Irfan Rahman
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
Molecular nutrition & food research 2008;52(9):987-94.
2008: Indika Edirisinghe; Se-Ran Yang; Hongwei Yao; Saravanan Rajendrasozhan; Samuel Caito; David Adenuga; Chelsea Wong; Arshad Rahman; Richard P Phipps; Zheng-Gen Jin; Irfan Rahman
VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2297-310.
2008: Hongwei Yao; Se-Ran Yang; Indika Edirisinghe; Saravanan Rajendrasozhan; Samuel Caito; David Adenuga; Michael A O'Reilly; Irfan Rahman
Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice.
American journal of respiratory cell and molecular biology 2008;39(1):7-18.
2008: Hongwei Yao; Indika Edirisinghe; Saravanan Rajendrasozhan; Se-Ran Yang; Samuel Caito; David Adenuga; Irfan Rahman
Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice.
American journal of physiology. Lung cellular and molecular physiology 2008;294(6):L1174-86.
2008: Se-Ran Yang; Samantha Valvo; Hongwei Yao; Aruna Kode; Saravanan Rajendrasozhan; Indika Edirisinghe; Samuel Caito; David Adenuga; Ryan Henry; George Fromm; Sanjay B Maggirwar; Jian-Dong Li; Michael Bulger; Irfan Rahman
IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung.
American journal of respiratory cell and molecular biology 2008;38(6):689-98.
2008: Hongwei Yao; Indika Edirisinghe; Se-Ran Yang; Saravanan Rajendrasozhan; Aruna Kode; Samuel Caito; David Adenuga; Irfan Rahman
Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice.
The American journal of pathology 2008;172(5):1222-37.
2008: Saravanan Rajendrasozhan; Se-Ran Yang; Vuokko L Kinnula; Irfan Rahman
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2008;177(8):861-70.
2008: Saravanan Rajendrasozhan; Se-Ran Yang; Indika Edirisinghe; Hongwei Yao; David Adenuga; Irfan Rahman
Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD.
Antioxidants & redox signaling 2008;10(4):799-811.
2008: Aruna Kode; Saravanan Rajendrasozhan; Samuel Caito; Se-Ran Yang; Ian L Megson; Irfan Rahman
Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2008;294(3):L478-88.
2008: Elizabeth P Ryan; Timothy Bushnell; Alan E Friedman; Irfan Rahman; Richard P Phipps
Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells.
Cancer immunology, immunotherapy : CII 2008;57(3):347-58.
2008: Samuel Caito; Se-Ran Yang; Aruna Kode; Indika Edirisinghe; Saravanan Rajendrasozhan; Richard P Phipps; Irfan Rahman
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages.
Antioxidants & redox signaling 2008;10(2):253-60.
2007: H Yao; Se-Ran Yang; Aruna Kode; S Rajendrasozhan; S Caito; D Adenuga; R Henry; I Edirisinghe; Irfan Rahman
Redox regulation of lung inflammation: role of NADPH oxidase and NF-kappaB signalling.
Biochemical Society transactions 2007;35(Pt 5):1151-5.
2007: Christopher S Stevenson; Cerys Docx; Ruth Webster; Cliff Battram; Debra Hynx; June Giddings; Philip R Cooper; Probir Chakravarty; Irfan Rahman; John A Marwick; Paul A Kirkham; Christine Charman; Delwood L Richardson; N R Nirmala; Paul Whittaker; Keith Butler
Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation.
American journal of physiology. Lung cellular and molecular physiology 2007;293(5):L1183-93.
2007: Se-Ran Yang; Jessica Wright; Mark R Bauter; Kathryn Seweryniak; Aruna Kode; Irfan Rahman
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.
American journal of physiology. Lung cellular and molecular physiology 2007;292(2):L567-76.
2006: Douglas Morrison; Irfan Rahman; William MacNee
Permeability, inflammation and oxidant status in airspace epithelium exposed to ozone.
Respiratory medicine 2006;100(12):2227-34.
2006: Irfan Rahman; Saibal K Biswas; Paul A Kirkham
Regulation of inflammation and redox signaling by dietary polyphenols.
Biochemical pharmacology 2006;72(11):1439-52.
2006: Irfan Rahman; I M Adcock
Oxidative stress and redox regulation of lung inflammation in COPD.
The European respiratory journal 2006;28(1):219-42.
2006: Se-Ran Yang; Asiya S Chida; Mark R Bauter; Nusrat Shafiq; Kathryn Seweryniak; Sanjay B Maggirwar; Iain Kilty; Irfan Rahman
Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages.
American journal of physiology. Lung cellular and molecular physiology 2006;291(1):L46-57.
2006: Carolyn J Baglole; Seth M Bushinsky; Tatiana M Garcia; Aruna Kode; Irfan Rahman; Patricia J Sime; Richard P Phipps
Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema.
American journal of physiology. Lung cellular and molecular physiology 2006;291(1):L19-29.
2006: Irfan Rahman; Iain Kilty
Antioxidant therapeutic targets in COPD.
Current drug targets 2006;7(6):707-20.
2006: John A Marwick; Christopher S Stevenson; June Giddings; William MacNee; Keith Butler; Irfan Rahman; Paul A Kirkham
Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition.
American journal of physiology. Lung cellular and molecular physiology 2006;290(5):L897-908.
2006: Irfan Rahman; Saibal K Biswas; Aruna Kode
Oxidant and antioxidant balance in the airways and airway diseases.
European journal of pharmacology 2006;533(1-3):222-39.
2006: Irfan Rahman; Se-Ran Yang; Saibal K Biswas
Current concepts of redox signaling in the lungs.
Antioxidants & redox signaling 2006;8(3-4):681-9.
2006: Irfan Rahman
Antioxidant therapies in COPD.
International journal of chronic obstructive pulmonary disease 2006;1(1):15-29.
2006: Irfan Rahman; Aruna Kode; Saibal K Biswas
Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method.
Nature protocols 2006;1(6):3159-65.
2006: Aruna Kode; Se-Ran Yang; Irfan Rahman
Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells.
Respiratory research 2006;7():132.
2005: Saibal K Biswas; David E Newby; Irfan Rahman; Ian L Megson
Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice.
Biochemical and biophysical research communications 2005;338(3):1368-73.
2005: Irfan Rahman
Regulation of glutathione in inflammation and chronic lung diseases.
Mutation research 2005;579(1-2):58-80.
2005: Fabrizio Luppi; Jamil Aarbiou; Sandra van Wetering; Irfan Rahman; Willem I de Boer; Klaus F Rabe; Pieter S Hiemstra
Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione.
Respiratory research 2005;6():140.
2005: Irfan Rahman
Oxidative stress in pathogenesis of chronic obstructive pulmonary disease: cellular and molecular mechanisms.
Cell biochemistry and biophysics 2005;43(1):167-88.
2005: Irfan Rahman
The role of oxidative stress in the pathogenesis of COPD: implications for therapy.
Treatments in respiratory medicine 2005;4(3):175-200.
2005: Irfan Rahman; Saibal K Biswas; Luis A Jimenez; Martine Torres; H J Forman
Glutathione, stress responses, and redox signaling in lung inflammation.
Antioxidants & redox signaling 2005;7(1-2):42-59.
2005: Saibal K Biswas; Danny McClure; Luis A Jimenez; Ian L Megson; Irfan Rahman
Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity.
Antioxidants & redox signaling 2005;7(1-2):32-41.
2004: Fiona M Moodie; John A Marwick; Charlotte S Anderson; Patryk Szulakowski; Saibal K Biswas; Mark R Bauter; Iain Kilty; Irfan Rahman
Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(15):1897-9.
2004: John A Marwick; Paul A Kirkham; Christopher S Stevenson; Henry Danahay; June Giddings; Keith Butler; Ken Donaldson; William MacNee; Irfan Rahman
Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.
American journal of respiratory cell and molecular biology 2004;31(6):633-42.
2004: Irfan Rahman; John A Marwick; Paul A Kirkham
Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression.
Biochemical pharmacology 2004;68(6):1255-67.
2004: Frank Antonicelli; David Brown; Maryline Parmentier; Ellen M Drost; Nik Hirani; Irfan Rahman; Ken Donaldson; William MacNee
Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn.
American journal of physiology. Lung cellular and molecular physiology 2004;286(6):L1319-27.
2004: Paul A Kirkham; Gillian Spooner; Irfan Rahman; Adriano G Rossi
Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products.
Biochemical and biophysical research communications 2004;318(1):32-7.
2004: Irfan Rahman; Saibal K Biswas
Non-invasive biomarkers of oxidative stress: reproducibility and methodological issues.
Redox report : communications in free radical research 2004;9(3):125-43.
2003: Irfan Rahman; Frank Kelly
Biomarkers in breath condensate: a promising new non-invasive technique in free radical research.
Free radical research 2003;37(12):1253-66.
2003: Julie A Wickenden; Murray C H Clarke; Adriano G Rossi; Irfan Rahman; Stephen P Faux; Ken Donaldson; William MacNee
Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis.
American journal of respiratory cell and molecular biology 2003;29(5):562-70.
2003: Ken Donaldson; Vicki Stone; Paul J A Borm; Luis A Jimenez; Peter S Gilmour; Roel P F Schins; Ad M Knaapen; Irfan Rahman; Stephen P Faux; David M Brown; William MacNee
Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10).
Free radical biology & medicine 2003;34(11):1369-82.
2003: Irfan Rahman; Aldo Tomasi
2nd International Meeting on Free Radicals in Health and Disease. The role of oxidants and antioxidants in the regulation of chronic diseases, may 8-12, 2002, Istanbul, Turkey.
Free radical research 2003;37(4):349-54.
2003: Irfan Rahman; Peter S Gilmour; Luis A Jimenez; Saibal K Biswas; Frank Antonicelli; Okezie I Aruoma
Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells.
Biochemical and biophysical research communications 2003;302(4):860-4.
2003: Peter S Gilmour; Irfan Rahman; Ken Donaldson; William MacNee
Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles.
American journal of physiology. Lung cellular and molecular physiology 2003;284(3):L533-40.
2003: Irfan Rahman
Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases.
Journal of biochemistry and molecular biology 2003;36(1):95-109.
2002: John A Marwick; Paul A Kirkham; Peter S Gilmour; Ken Donaldson; William MacNee; Irfan Rahman
Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells.
Annals of the New York Academy of Sciences 2002;973():278-83.
2002: Monica Deiana; M Assunta Dessi; Bin Ke; Yun-Fei Liang; Teruo Higa; Peter S Gilmour; Ling-Sun Jen; Irfan Rahman; Okezie I Aruoma
The antioxidant cocktail effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro.
Biochemical and biophysical research communications 2002;296(5):1148-51.
2002: Irfan Rahman
Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets.
Current drug targets. Inflammation and allergy 2002;1(3):291-315.
2002: Irfan Rahman
Oxidative stress, transcription factors and chromatin remodelling in lung inflammation.
Biochemical pharmacology 2002;64(5-6):935-42.
2002: Irfan Rahman; Annemarie van Schadewijk; Ann J L Crowther; Pieter S Hiemstra; Jan Stolk; William MacNee; Willem I de Boer
4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2002;166(4):490-5.
2002: Hazel Jardine; William MacNee; Ken Donaldson; Irfan Rahman
Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1.
The Journal of biological chemistry 2002;277(24):21158-66.
2002: Irfan Rahman; Peter S Gilmour; Luis A Jimenez; William MacNee
Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation.
Molecular and cellular biochemistry 2002;234-235(1-2):239-48.
2002: Frank Antonicelli; Maryline Parmentier; Ellen M Drost; Nik Hirani; Irfan Rahman; Ken Donaldson; William MacNee
Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappaB nuclear binding in alveolar epithelial cells.
Free radical biology & medicine 2002;32(6):492-502.
2002: Luis A Jiménez; Ellen M Drost; Peter S Gilmour; Irfan Rahman; Frank Antonicelli; H Ritchie; William MacNee; Ken Donaldson
PM(10)-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-alpha.
American journal of physiology. Lung cellular and molecular physiology 2002;282(2):L237-48.
2002: Jonathan P Coe; Irfan Rahman; Nathalie Sphyris; Alan R Clarke; David J Harrison
Glutathione and p53 independently mediate responses against oxidative stress in ES cells.
Free radical biology & medicine 2002;32(2):187-96.
2001: Irfan Rahman; B Mulier; Peter S Gilmour; Tammy M Watchorn; Ken Donaldson; P K Jeffery; William MacNee
Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB.
Biochemical pharmacology 2001;62(6):787-94.
2001: Peter S Gilmour; Irfan Rahman; S Hayashi; J C Hogg; Ken Donaldson; William MacNee
Adenoviral E1A primes alveolar epithelial cells to PM(10)-induced transcription of interleukin-8.
American journal of physiology. Lung cellular and molecular physiology 2001;281(3):L598-606.
2000: Maryline Parmentier; Nik Hirani; Irfan Rahman; Ken Donaldson; William MacNee; Frank Antonicelli
Regulation of lipopolysaccharide-mediated interleukin-1beta release by N-acetylcysteine in THP-1 cells.
The European respiratory journal 2000;16(5):933-9.
2000: Irfan Rahman
Regulation of nuclear factor-kappa B, activator protein-1, and glutathione levels by tumor necrosis factor-alpha and dexamethasone in alveolar epithelial cells.
Biochemical pharmacology 2000;60(8):1041-9.
2000: Irfan Rahman; William MacNee
Oxidative stress and regulation of glutathione in lung inflammation.
The European respiratory journal 2000;16(3):534-54.
2000: Luis A Jiménez; J Thompson; D A Brown; Irfan Rahman; Frank Antonicelli; Rodger Duffin; Ellen M Drost; Ron Thomas Hay; Ken Donaldson; William MacNee
Activation of NF-kappaB by PM(10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation.
Toxicology and applied pharmacology 2000;166(2):101-10.
2000: Irfan Rahman; William MacNee
Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches.
Free radical biology & medicine 2000;28(9):1405-20.
2000: Irfan Rahman; Annemarie van Schadewijk; Pieter S Hiemstra; Jan Stolk; J H van Krieken; William MacNee; Willem I de Boer
Localization of gamma-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease.
Free radical biology & medicine 2000;28(6):920-5.
2000: C Ward; T H Wong; J Murray; Irfan Rahman; Christopher Haslett; Edwin R Chilvers; Adriano G Rossi
Induction of human neutrophil apoptosis by nitric oxide donors: evidence for a caspase-dependent, cyclic-GMP-independent, mechanism.
Biochemical pharmacology 2000;59(3):305-14.
1999: Irfan Rahman; William MacNee
Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease.
The American journal of physiology 1999;277(6 Pt 1):L1067-88.
1999: William MacNee; Irfan Rahman
Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 1999;160(5 Pt 2):S58-65.
1999: Irfan Rahman; E Skwarska; M Henry; M Davis; C M O'Connor; M X FitzGerald; Andrew P Greening; William MacNee
Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis.
Free radical biology & medicine 1999;27(1-2):60-8.
1999: Irfan Rahman; Frank Antonicelli; William MacNee
Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-alpha and dexamethasone in human alveolar epithelial cells.
The Journal of biological chemistry 1999;274(8):5088-96.
1999: D Morrison; Irfan Rahman; S Lannan; William MacNee
Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers.
American journal of respiratory and critical care medicine 1999;159(2):473-9.
1999: Thérèse S Lapperre; Luis A Jimenez; Frank Antonicelli; Ellen M Drost; Pieter S Hiemstra; Jan Stolk; William MacNee; Irfan Rahman
Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells.
FEBS letters 1999;443(2):235-9.
1999: Irfan Rahman
Inflammation and the regulation of glutathione level in lung epithelial cells.
Antioxidants & redox signaling 1999;1(4):425-47.
1998: Irfan Rahman; William MacNee
Role of transcription factors in inflammatory lung diseases.
Thorax 1998;53(7):601-12.
1998: Irfan Rahman; A Bel; B Mulier; Ken Donaldson; William MacNee
Differential regulation of glutathione by oxidants and dexamethasone in alveolar epithelial cells.
The American journal of physiology 1998;275(1 Pt 1):L80-6.
1998: A G Rossi; Christopher Haslett; Nik Hirani; Andrew P Greening; Irfan Rahman; CN Metz; R Bucala; Seamas C Donnelly
Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma.
The Journal of clinical investigation 1998;101(12):2869-74.
1998: Irfan Rahman; C A Smith; Frank Antonicelli; William MacNee
Characterisation of gamma-glutamylcysteine synthetase-heavy subunit promoter: a critical role for AP-1.
FEBS letters 1998;427(1):129-33.
1998: B Mulier; Irfan Rahman; Tammy M Watchorn; Ken Donaldson; William MacNee; P K Jeffery
Hydrogen peroxide-induced epithelial injury: the protective role of intracellular nonprotein thiols (NPSH).
The European respiratory journal 1998;11(2):384-91.
1997: Peter S Gilmour; David M Brown; PH Beswick; William MacNee; Irfan Rahman; Ken Donaldson
Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors.
Environmental health perspectives 1997;105 Suppl 5():1313-7.
1997: Irfan Rahman; E Skwarska; William MacNee
Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease.
Thorax 1997;52(6):565-8.
1996: Irfan Rahman; A Bel; B Mulier; M F Lawson; David J Harrison; William MacNee; C A Smith
Transcriptional regulation of gamma-glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells.
Biochemical and biophysical research communications 1996;229(3):832-7.
1996: Irfan Rahman; C A Smith; M F Lawson; David J Harrison; William MacNee
Induction of gamma-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells.
FEBS letters 1996;396(1):21-5.
1996: Irfan Rahman; D Morrison; Ken Donaldson; William MacNee
Systemic oxidative stress in asthma, COPD, and smokers.
American journal of respiratory and critical care medicine 1996;154(4 Pt 1):1055-60.
1996: X Y Li; Irfan Rahman; Ken Donaldson; William MacNee
Mechanisms of cigarette smoke induced increased airspace permeability.
Thorax 1996;51(5):465-71.
1996: William MacNee; D Morrison; Irfan Rahman; X Y Li; Ken Donaldson
Cigarette smoke and ozone-induced epithelial perturbation in vivo and in vitro. The role of glutathione.
Chest 1996;109(3 Suppl):39S.
1996: Irfan Rahman; William MacNee
Role of oxidants/antioxidants in smoking-induced lung diseases.
Free radical biology & medicine 1996;21(5):669-81.
1995: S Hannah; K Mecklenburgh; Irfan Rahman; G J Bellingan; A Greening; C Haslett; Edwin R Chilvers
Hypoxia prolongs neutrophil survival in vitro.
FEBS letters 1995;372(2-3):233-7.
1995: Irfan Rahman; X Y Li; Ken Donaldson; David J Harrison; William MacNee
Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress.
The American journal of physiology 1995;269(3 Pt 1):L285-92.
1995: William MacNee; Irfan Rahman
Oxidants/antioxidants in idiopathic pulmonary fibrosis.
Thorax 1995;50 Suppl 1():S53-8.
1995: Irfan Rahman; X Y Li; Ken Donaldson; William MacNee
Cigarette smoke, glutathione metabolism and epithelial permeability in rat lungs.
Biochemical Society transactions 1995;23(2):235S.