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Ronald Raines

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TOP 3
Michael N Levine; Trish T Hoang; Ronald T Raines
Fluorogenic probe for constitutive cellular endocytosis.
Kevin K Desai; George N Phillips; Craig A Bingman; Ronald T Raines
Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation.
Tzu-Yuan Chao; Ronald T Raines
Fluorogenic label to quantify the cytosolic delivery of macromolecules.

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All Publications

2013: Michael N Levine; Trish T Hoang; Ronald T Raines
Fluorogenic probe for constitutive cellular endocytosis.
Chemistry & biology 2013;20(4):614-8.
2013: Kevin K Desai; George N Phillips; Craig A Bingman; Ronald T Raines
Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation.
Biochemistry 2013;52(15):2518-25.
2013: Tzu-Yuan Chao; Ronald T Raines
Fluorogenic label to quantify the cytosolic delivery of macromolecules.
Molecular bioSystems 2013;9(3):339-42.
2013: Ulrich Arnold; Samuel H Gellman; Bayard R Huck; Ronald T Raines
Protein prosthesis: β-peptides as reverse-turn surrogates.
Protein science : a publication of the Protein Society 2013;22(3):274-9.
2013: Kimberli J Kamer; Amit Choudhary; Ronald T Raines
Intimate interactions with carbonyl groups: dipole-dipole or n→π*?
The Journal of organic chemistry 2013;78(5):2099-103.
2012: Sayani Chattopadhyay; Jonathan F McAnulty; Christopher J Murphy; Ronald T Raines
Peptides that anneal to natural collagen in vitro and ex vivo.
Organic & biomolecular chemistry 2012;10(30):5892-7.
2012: Michael J Palte; Amy K F Davis; Nicholas A McGrath; Carol A Spiegel; Ronald T Raines
Ribonucleoside 3'-phosphates as pro-moieties for an orally administered drug.
ChemMedChem 2012;7(8):1361-4.
2012: Grant R Krow; Patrick Carroll; Amit Choudhary; Charles DeBrosse; Ramakrishna Edupuganti; Deepa Gandla; Charles W Ross; Matthew Sender; Matthew D Shoulders; Philip E Sonnet; Fang Yu; Ronald T Raines
Synthesis of 5-fluoro- and 5-hydroxymethanoprolines via lithiation of N-BOC-methanopyrrolidines. Constrained Cγ-exo and Cγ-endo Flp and Hyp conformer mimics.
The Journal of organic chemistry 2012;77(12):5331-44.
2012: Michael J Palte; Ronald T Raines
Interaction of nucleic acids with the glycocalyx.
Journal of the American Chemical Society 2012;134(14):6218-23.
2012: John C Lukesh; Michael J Palte; Ronald T Raines
A potent, versatile disulfide-reducing agent from aspartic acid.
Journal of the American Chemical Society 2012;134(9):4057-9.
2012: Gregory A Ellis; Michael J Palte; Ronald T Raines
Boronate-mediated biologic delivery.
Journal of the American Chemical Society 2012;134(8):3631-4.
2012: Kevin K Desai; Ronald T Raines
tRNA ligase catalyzes the GTP-dependent ligation of RNA with 3'-phosphate and 5'-hydroxyl termini.
Biochemistry 2012;51(7):1333-5.
2012: Amit Choudhary; Kimberli J Kamer; Ronald T Raines
A conserved interaction with the chromophore of fluorescent proteins.
Protein science : a publication of the Protein Society 2012;21(2):171-7.
2011: Nadia K Sundlass; Ronald T Raines
Arginine residues are more effective than lysine residues in eliciting the cellular uptake of onconase.
Biochemistry 2011;50(47):10293-9.
2011: Michael N Levine; Ronald T Raines
Sensitive fluorogenic substrate for alkaline phosphatase.
Analytical biochemistry 2011;418(2):247-52.
2011: Amit Choudhary; Kimberli J Kamer; Ronald T Raines
An n→π* interaction in aspirin: implications for structure and reactivity.
The Journal of organic chemistry 2011;76(19):7933-7.
2011: Tzu-Yuan Chao; Ronald T Raines
Mechanism of ribonuclease A endocytosis: analogies to cell-penetrating peptides.
Biochemistry 2011;50(39):8374-82.
2011: Nicholas A McGrath; Ronald T Raines
Chemoselectivity in chemical biology: acyl transfer reactions with sulfur and selenium.
Accounts of chemical research 2011;44(9):752-61.
2011: Bryan D Smith; Joshua J Higgin; Ronald T Raines
Site-specific folate conjugation to a cytotoxic protein.
Bioorganic & medicinal chemistry letters 2011;21(17):5029-32.
2011: Amit Choudhary; Ronald T Raines
An evaluation of peptide-bond isosteres.
Chembiochem : a European journal of chemical biology 2011;12(12):1801-7.
2011: Amit Choudhary; Ronald T Raines
Signature of n→π* interactions in α-helices.
Protein science : a publication of the Protein Society 2011;20(6):1077-81.
2011: Amit Choudhary; Khian Hong Pua; Ronald T Raines
Quantum mechanical origin of the conformational preferences of 4-thiaproline and its S-oxides.
Amino acids 2011;41(1):181-6.
2011: Grant R Krow; Ram Edupuganti; Deepa Gandla; Fang Yu; Matthew Sender; Philip E Sonnet; Michael J Zdilla; Charles DeBrosse; Kevin C Cannon; Charles W Ross; Amit Choudhary; Matthew D Shoulders; Ronald T Raines
Synthesis of conformationally constrained 5-fluoro- and 5-hydroxymethanopyrrolidines. Ring-puckered mimics of gauche- and anti-3-fluoro- and 3-hydroxypyrrolidines.
The Journal of organic chemistry 2011;76(10):3626-34.
2011: Gregory A Ellis; Megan L Hornung; Ronald T Raines
Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer.
Bioorganic & medicinal chemistry letters 2011;21(9):2756-8.
2011: Benjamin R Caes; Ronald T Raines
Conversion of fructose into 5-(hydroxymethyl)furfural in sulfolane.
ChemSusChem 2011;4(3):353-6.
2011: Nethaji Thiyagarajan; Bryan D Smith; Ronald T Raines; K Ravi Acharya
Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A.
The FEBS journal 2011;278(3):541-9.
2011: Rex W Watkins; Ulrich Arnold; Ronald T Raines
Ribonuclease S redux.
Chemical communications (Cambridge, England) 2011;47(3):973-5.
2010: Tzu-Yuan Chao; Luke D Lavis; Ronald T Raines
Cellular uptake of ribonuclease A relies on anionic glycans.
Biochemistry 2010;49(50):10666-73.
2010: Grant R Krow; Nian Liu; Matthew Sender; Guoliang Lin; Ryan Centafont; Philip E Sonnet; Charles DeBrosse; Charles W Ross; Patrick J Carroll; Matthew D Shoulders; Ronald T Raines
Oligomers of a 5-carboxy-methanopyrrolidine β-amino acid. A search for order.
Organic letters 2010;12(23):5438-41.
2010: Langdon J Martin; Ronald T Raines
Carpe diubiquitin.
Angewandte Chemie (International ed. in English) 2010;49(48):9042-4.
2010: Joseph B Binder; Jacqueline J Blank; Anthony V Cefali; Ronald T Raines
Synthesis of furfural from xylose and xylan.
ChemSusChem 2010;3(11):1268-72.
2010: Thomas J Rutkoski; John A Kink; Laura E Strong; Christine I Schilling; Ronald T Raines
Antitumor activity of ribonuclease multimers created by site-specific covalent tethering.
Bioconjugate chemistry 2010;21(9):1691-702.
2010: Matthew D Shoulders; Frank W Kotch; Amit Choudhary; Ilia A Guzei; Ronald T Raines
The aberrance of the 4S diastereomer of 4-hydroxyproline.
Journal of the American Chemical Society 2010;132(31):10857-65.
2010: Kelly L Gorres; Ronald T Raines
Prolyl 4-hydroxylase.
Critical reviews in biochemistry and molecular biology 2010;45(2):106-24.
2010: Joseph B Binder; Ronald T Raines
Fermentable sugars by chemical hydrolysis of biomass.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(10):4516-21.
2010: Matthew D Shoulders; Kenneth A Satyshur; Katrina T Forest; Ronald T Raines
Stereoelectronic and steric effects in side chains preorganize a protein main chain.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):559-64.
2009: Grant R Krow; Ram Edupuganti; Deepa Gandla; Amit Choudhary; Guoliang Lin; Philip E Sonnet; Charles DeBrosse; Charles W Ross; Kevin C Cannon; Ronald T Raines
5(6)-anti-Substituted-2-azabicyclo[2.1.1]hexanes: a nucleophilic displacement route.
The Journal of organic chemistry 2009;74(21):8232-42.
2009: Rex W Watkins; Luke D Lavis; Vanessa M Kung; Georgyi V Los; Ronald T Raines
Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells.
Organic & biomolecular chemistry 2009;7(19):3969-75.
2009: Matthew D Shoulders; Kimberli J Kamer; Ronald T Raines
Origin of the stability conferred upon collagen by fluorination.
Bioorganic & medicinal chemistry letters 2009;19(14):3859-62.
2009: Rebecca F Turcotte; Luke D Lavis; Ronald T Raines
Onconase cytotoxicity relies on the distribution of its positive charge.
The FEBS journal 2009;276(14):3846-57.
2009: Kimberly A Dickson; Ronald T Raines
Silencing an inhibitor unleashes a cytotoxic enzyme.
Biochemistry 2009;48(23):5051-3.
2009: Amit Choudhary; Deepa Gandla; Grant R Krow; Ronald T Raines
Nature of amide carbonyl--carbonyl interactions in proteins.
Journal of the American Chemical Society 2009;131(21):7244-6.
2009: Kimberly A Dickson; Dong-Ku Kang; Young Sam Kwon; Jae Chan Kim; Peter A Leland; BM Kim; Soo-Ik Chang; Ronald T Raines
Ribonuclease inhibitor regulates neovascularization by human angiogenin.
Biochemistry 2009;48(18):3804-6.
2009: Kelly L Gorres; Ronald T Raines
Direct and continuous assay for prolyl 4-hydroxylase.
Analytical biochemistry 2009;386(2):181-5.
2009: Joseph B Binder; Ronald T Raines
Simple chemical transformation of lignocellulosic biomass into furans for fuels and chemicals.
Journal of the American Chemical Society 2009;131(5):1979-85.
2009: Annie Tam; Ronald T Raines
Coulombic effects on the traceless Staudinger ligation in water.
Bioorganic & medicinal chemistry 2009;17(3):1055-63.
2009: Kelly L Gorres; Khian Hong Pua; Ronald T Raines
Stringency of the 2-His-1-Asp active-site motif in prolyl 4-hydroxylase.
PloS one 2009;4(11):e7635.
2009: Matthew D Shoulders; Ronald T Raines
Modulating collagen triple-helix stability with 4-chloro, 4-fluoro, and 4-methylprolines.
Advances in experimental medicine and biology 2009;611():251-2.
2009: Ronald T Raines
Stronger and (now) longer synthetic collagen.
Advances in experimental medicine and biology 2009;611():xci-xcviii.
2009: Matthew D Shoulders; Ronald T Raines
Collagen structure and stability.
Annual review of biochemistry 2009;78():929-58.
2009: Eddie L Myers; Ronald T Raines
A phosphine-mediated conversion of azides into diazo compounds.
Angewandte Chemie (International ed. in English) 2009;48(13):2359-63.
2008: Rebecca F Turcotte; Ronald T Raines
Interaction of onconase with the human ribonuclease inhibitor protein.
Biochemical and biophysical research communications 2008;377(2):512-4.
2008: Melissa M Yatzeck; Luke D Lavis; Tzu-Yuan Chao; Sunil S Chandran; Ronald T Raines
A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells.
Bioorganic & medicinal chemistry letters 2008;18(22):5864-6.
2008: Rebecca F Turcotte; Ronald T Raines
Design and characterization of an HIV-specific ribonuclease zymogen.
AIDS research and human retroviruses 2008;24(11):1357-63.
2008: Kelly L Gorres; Ram Edupuganti; Grant R Krow; Ronald T Raines
Conformational preferences of substrates for human prolyl 4-hydroxylase.
Biochemistry 2008;47(36):9447-55.
2008: Thomas J Rutkoski; Ronald T Raines
Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity.
Current pharmaceutical biotechnology 2008;9(3):185-9.
2008: Ronald T Raines
Jeremy R. Knowles (1935-2008).
ACS chemical biology 2008;3(5):262-4.
2008: Bryan D Smith; Ronald T Raines
Genetic selection for peptide inhibitors of angiogenin.
Protein engineering, design & selection : PEDS 2008;21(5):289-94.
2008: Matthew D Shoulders; Ilia A Guzei; Ronald T Raines
4-chloroprolines: synthesis, conformational analysis, and effect on the collagen triple helix.
Biopolymers 2008;89(5):443-54.
2008: Annie Tam; Matthew B Soellner; Ronald T Raines
Electronic and steric effects on the rate of the traceless Staudinger ligation.
Organic & biomolecular chemistry 2008;6(7):1173-5.
2008: Luke D Lavis; Ronald T Raines
Bright ideas for chemical biology.
ACS chemical biology 2008;3(3):142-55.
2008: Frank W Kotch; Ilia A Guzei; Ronald T Raines
Stabilization of the collagen triple helix by O-methylation of hydroxyproline residues.
Journal of the American Chemical Society 2008;130(10):2952-3.
2008: J Eugene Lee; Euiyoung Bae; Craig A Bingman; George N Phillips; Ronald T Raines
Structural basis for catalysis by onconase.
Journal of molecular biology 2008;375(1):165-77.
2008: Jeet Kalia; Ronald T Raines
Hydrolytic stability of hydrazones and oximes.
Angewandte Chemie (International ed. in English) 2008;47(39):7523-6.
2008: Michael N Levine; Luke D Lavis; Ronald T Raines
Trimethyl lock: a stable chromogenic substrate for esterases.
Molecules (Basel, Switzerland) 2008;13(2):204-11.
2008: J Eugene Lee; Ronald T Raines
Ribonucleases as novel chemotherapeutics : the ranpirnase example.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2008;22(1):53-8.
2007: Jeet Kalia; Ronald T Raines
Catalysis of imido group hydrolysis in a maleimide conjugate.
Bioorganic & medicinal chemistry letters 2007;17(22):6286-9.
2007: R Jeremy Johnson; Luke D Lavis; Ronald T Raines
Intraspecies regulation of ribonucleolytic activity.
Biochemistry 2007;46(45):13131-40.
2007: Joseph B Binder; Jacqueline J Blank; Ronald T Raines
Olefin metathesis in homogeneous aqueous media catalyzed by conventional ruthenium catalysts.
Organic letters 2007;9(23):4885-8.
2007: Annie Tam; Ulrich Arnold; Matthew B Soellner; Ronald T Raines
Protein prosthesis: 1,5-disubstituted[1,2,3]triazoles as cis-peptide bond surrogates.
Journal of the American Chemical Society 2007;129(42):12670-1.
2007: Stephen M Fuchs; Thomas J Rutkoski; Vanessa M Kung; Ryan T Groeschl; Ronald T Raines
Increasing the potency of a cytotoxin with an arginine graft.
Protein engineering, design & selection : PEDS 2007;20(10):505-9.
2007: Annie Tam; Matthew B Soellner; Ronald T Raines
Water-soluble phosphinothiols for traceless staudinger ligation and integration with expressed protein ligation.
Journal of the American Chemical Society 2007;129(37):11421-30.
2007: Thimmaiah Govindaraju; Paul J Bertics; Ronald T Raines; Nicholas L Abbott
Using measurements of anchoring energies of liquid crystals on surfaces to quantify proteins captured by immobilized ligands.
Journal of the American Chemical Society 2007;129(36):11223-31.
2007: R Jeremy Johnson; Tzu-Yuan Chao; Luke D Lavis; Ronald T Raines
Cytotoxic ribonucleases: the dichotomy of Coulombic forces.
Biochemistry 2007;46(36):10308-16.
2007: Luke D Lavis; Thomas J Rutkoski; Ronald T Raines
Tuning the pK(a) of fluorescein to optimize binding assays.
Analytical chemistry 2007;79(17):6775-82.
2007: R Jeremy Johnson; Shawn R Lin; Ronald T Raines
Genetic selection reveals the role of a buried, conserved polar residue.
Protein science : a publication of the Protein Society 2007;16(8):1609-16.
2007: Jeet Kalia; Nicholas L Abbott; Ronald T Raines
General method for site-specific protein immobilization by Staudinger ligation.
Bioconjugate chemistry 2007;18(4):1064-9.
2007: R Jeremy Johnson; Jason G McCoy; Craig A Bingman; George N Phillips; Ronald T Raines
Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein.
Journal of molecular biology 2007;368(2):434-49.
2007: Christopher M Jewell; Stephen M Fuchs; Ryan M Flessner; Ronald T Raines; David M Lynn
Multilayered films fabricated from an oligoarginine-conjugated protein promote efficient surface-mediated protein transduction.
Biomacromolecules 2007;8(3):857-63.
2007: Jia-Cherng Horng; Frank W Kotch; Ronald T Raines
Is glycine a surrogate for a D-amino acid in the collagen triple helix?
Protein science : a publication of the Protein Society 2007;16(2):208-15.
2006: Matthew B Soellner; Annie Tam; Ronald T Raines
Staudinger ligation of peptides at non-glycyl residues.
The Journal of organic chemistry 2006;71(26):9824-30.
2006: R Jeremy Johnson; Shawn R Lin; Ronald T Raines
A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus.
The FEBS journal 2006;273(23):5457-65.
2006: Jia-Cherng Horng; Andrew J Hawk; Qian Zhao; Eric S Benedict; Steven D Burke; Ronald T Raines
Macrocyclic scaffold for the collagen triple helix.
Organic letters 2006;8(21):4735-8.
2006: Jonathan A Hodges; Ronald T Raines
Energetics of an n --> pi interaction that impacts protein structure.
Organic letters 2006;8(21):4695-7.
2006: Bryan D Smith; Ronald T Raines
Genetic selection for critical residues in ribonucleases.
Journal of molecular biology 2006;362(3):459-78.
2006: Laura L Kiessling; Sally Garbo Wedde; Ronald T Raines
Symbiosis: Chemical biology at Wisconsin.
ACS chemical biology 2006;1(8):481-4.
2006: Jeet Kalia; Ronald T Raines
Reactivity of intein thioesters: appending a functional group to a protein.
Chembiochem : a European journal of chemical biology 2006;7(9):1375-83.
2006: Xiaosong Liu; Chang-Hyun Jang; Fan Zheng; Astrid Jürgensen; J D Denlinger; Kimberly A Dickson; Ronald T Raines; Nicholas L Abbott; FJ Himpsel
Characterization of protein immobilization at silver surfaces by near edge X-ray absorption fine structure spectroscopy.
Langmuir : the ACS journal of surfaces and colloids 2006;22(18):7719-25.
2006: Stephen M Fuchs; Ronald T Raines
Internalization of cationic peptides: the road less (or more?) traveled.
Cellular and molecular life sciences : CMLS 2006;63(16):1819-22.
2006: Luke D Lavis; Tzu-Yuan Chao; Ronald T Raines
Latent blue and red fluorophores based on the trimethyl lock.
Chembiochem : a European journal of chemical biology 2006;7(8):1151-4.
2006: Matthew B Soellner; Bradley Nilsson; Ronald T Raines
Reaction mechanism and kinetics of the traceless Staudinger ligation.
Journal of the American Chemical Society 2006;128(27):8820-8.
2006: Matthew D Shoulders; Jonathan A Hodges; Ronald T Raines
Reciprocity of steric and stereoelectronic effects in the collagen triple helix.
Journal of the American Chemical Society 2006;128(25):8112-3.
2006: Matthew J Allen; Ronald T Raines; Laura L Kiessling
Contrast agents for magnetic resonance imaging synthesized with ring-opening metathesis polymerization.
Journal of the American Chemical Society 2006;128(20):6534-5.
2006: Luke D Lavis; Tzu-Yuan Chao; Ronald T Raines
Fluorogenic label for biomolecular imaging.
ACS chemical biology 2006;1(4):252-60.
2006: Ronald T Raines
2005 Emil Thomas Kaiser Award.
Protein science : a publication of the Protein Society 2006;15(5):1219-25.
2006: Brian E Eckenroth; Katharine Harris; Anton A Turanov; Vadim N Gladyshev; Ronald T Raines; Robert J Hondal
Semisynthesis and characterization of mammalian thioredoxin reductase.
Biochemistry 2006;45(16):5158-70.
2006: Frank W Kotch; Ronald T Raines
Self-assembly of synthetic collagen triple helices.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3028-33.
2006: Jia-Cherng Horng; Ronald T Raines
Stereoelectronic effects on polyproline conformation.
Protein science : a publication of the Protein Society 2006;15(1):74-83.
2005: J Eugene Lee; Ronald T Raines
Cytotoxicity of bovine seminal ribonuclease: monomer versus dimer.
Biochemistry 2005;44(48):15760-7.
2005: Thomas J Rutkoski; Erin L Kurten; Julie C Mitchell; Ronald T Raines
Disruption of shape-complementarity markers to create cytotoxic variants of ribonuclease A.
Journal of molecular biology 2005;354(1):41-54.
2005: Jonathan A Hodges; Ronald T Raines
Stereoelectronic and steric effects in the collagen triple helix: toward a code for strand association.
Journal of the American Chemical Society 2005;127(45):15923-32.
2005: Elizabeth A Kersteen; Seth R Barrows; Ronald T Raines
Catalysis of protein disulfide bond isomerization in a homogeneous substrate.
Biochemistry 2005;44(36):12168-78.
2005: Brian G Miller; Ronald T Raines
Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases.
Biochemistry 2005;44(32):10776-83.
2005: Cara L Jenkins; Melissa M Vasbinder; Scott J Miller; Ronald T Raines
Peptide bond isosteres: ester or (E)-alkene in the backbone of the collagen triple helix.
Organic letters 2005;7(13):2619-22.
2005: Stephen M Fuchs; Ronald T Raines
Polyarginine as a multifunctional fusion tag.
Protein science : a publication of the Protein Society 2005;14(6):1538-44.
2005: Sunil S Chandran; Kimberly A Dickson; Ronald T Raines
Latent fluorophore based on the trimethyl lock.
Journal of the American Chemical Society 2005;127(6):1652-3.
2005: Cara L Jenkins; Nethaji Thiyagarajan; Rozamond Y Sweeney; Michael P Guy; Bradley R Kelemen; K Ravi Acharya; Ronald T Raines
Binding of non-natural 3'-nucleotides to ribonuclease A.
The FEBS journal 2005;272(3):744-55.
2005: Bryan D Smith; Matthew B Soellner; Ronald T Raines
Synthetic surfaces for ribonuclease adsorption.
Langmuir : the ACS journal of surfaces and colloids 2005;21(1):187-90.
2005: Kimberly A Dickson; Marcia C Haigis; Ronald T Raines
Ribonuclease inhibitor: structure and function.
Progress in nucleic acid research and molecular biology 2005;80():349-74.
2005: Bradley Nilsson; Matthew B Soellner; Ronald T Raines
Chemical synthesis of proteins.
Annual review of biophysics and biomolecular structure 2005;34():91-118.
2005: Cara L Jenkins; Alexander I McCloskey; Ilia A Guzei; Eric S Eberhardt; Ronald T Raines
O-acylation of hydroxyproline residues: effect on peptide-bond isomerization and collagen stability.
Biopolymers 2005;80(1):1-8.
2004: Cara L Jenkins; Guoliang Lin; Jingqi Duo; Deepa Rapolu; Ilia A Guzei; Ronald T Raines; Grant R Krow
Substituted 2-azabicyclo[2.1.1]hexanes as constrained proline analogues: implications for collagen stability.
The Journal of organic chemistry 2004;69(25):8565-73.
2004: Elizabeth A Kersteen; Joshua J Higgin; Ronald T Raines
Production of human prolyl 4-hydroxylase in Escherichia coli.
Protein expression and purification 2004;38(2):279-91.
2004: Yan-Yeung Luk; Matthew L Tingey; Kimberly A Dickson; Ronald T Raines; Nicholas L Abbott
Imaging the binding ability of proteins immobilized on surfaces with different orientations by using liquid crystals.
Journal of the American Chemical Society 2004;126(29):9024-32.
2004: Alexander A Makarov; Gennady I Yakovlev; Vladmir Mitkevich; Joshua J Higgin; Ronald T Raines
Zinc(II)-mediated inhibition of ribonuclease Sa by an N-hydroxyurea nucleotide and its basis.
Biochemical and biophysical research communications 2004;319(1):152-6.
2004: Brian G Miller; Ronald T Raines
Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases.
Biochemistry 2004;43(21):6387-92.
2004: Stephen M Fuchs; Ronald T Raines
Pathway for polyarginine entry into mammalian cells.
Biochemistry 2004;43(9):2438-44.
2003: J Eugene Lee; Ronald T Raines
Contribution of active-site residues to the function of onconase, a ribonuclease with antitumoral activity.
Biochemistry 2003;42(39):11443-50.
2003: Matthew B Soellner; Kimberly A Dickson; Bradley Nilsson; Ronald T Raines
Site-specific protein immobilization by Staudinger ligation.
Journal of the American Chemical Society 2003;125(39):11790-1.
2003: Jonathan A Hodges; Ronald T Raines
Stereoelectronic effects on collagen stability: the dichotomy of 4-fluoroproline diastereomers.
Journal of the American Chemical Society 2003;125(31):9262-3.
2003: Elizabeth A Kersteen; Ronald T Raines
Catalysis of protein folding by protein disulfide isomerase and small-molecule mimics.
Antioxidants & redox signaling 2003;5(4):413-24.
2003: Kimberly A Dickson; Caroline L Dahlberg; Ronald T Raines
Compensating effects on the cytotoxicity of ribonuclease A variants.
Archives of biochemistry and biophysics 2003;415(2):172-7.
2003: Kenneth J Woycechowsky; Brad Hook; Ronald T Raines
Catalysis of protein folding by an immobilized small-molecule dithiol.
Biotechnology progress 2003;19(4):1307-14.
2003: Ulrich Arnold; Matthew P Hinderaker; Jens Köditz; Ralph Golbik; Renate Ulbrich-Hofmann; Ronald T Raines
Protein prosthesis: a nonnatural residue accelerates folding and increases stability.
Journal of the American Chemical Society 2003;125(25):7500-1.
2003: Bryan D Smith; Matthew B Soellner; Ronald T Raines
Potent inhibition of ribonuclease A by oligo(vinylsulfonic acid).
The Journal of biological chemistry 2003;278(23):20934-8.
2003: Gary Wright; Joshua J Higgin; Ronald T Raines; CHARLES STEENBERGEN; Elizabeth Murphy
Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes.
The Journal of biological chemistry 2003;278(22):20235-9.
2003: Cara L Jenkins; Lynn E Bretscher; Ilia A Guzei; Ronald T Raines
Effect of 3-hydroxyproline residues on collagen stability.
Journal of the American Chemical Society 2003;125(21):6422-7.
2003: Kenneth J Woycechowsky; Ronald T Raines
The CXC motif: a functional mimic of protein disulfide isomerase.
Biochemistry 2003;42(18):5387-94.
2003: Bradley Nilsson; Robert J Hondal; Matthew B Soellner; Ronald T Raines
Protein assembly by orthogonal chemical ligation methods.
Journal of the American Chemical Society 2003;125(18):5268-9.
2003: Chiwook Park; Ronald T Raines
Catalysis by ribonuclease A is limited by the rate of substrate association.
Biochemistry 2003;42(12):3509-18.
2003: Joshua J Higgin; Gennady I Yakovlev; Vladmir Mitkevich; Alexander A Makarov; Ronald T Raines
Zinc(II)-mediated inhibition of a ribonuclease by an N-hydroxyurea nucleotide.
Bioorganic & medicinal chemistry letters 2003;13(3):409-12.
2003: Marcia C Haigis; Erin L Kurten; Ronald T Raines
Ribonuclease inhibitor as an intracellular sentry.
Nucleic acids research 2003;31(3):1024-32.
2003: Parit Plainkum; Stephen M Fuchs; Suthep Wiyakrutta; Ronald T Raines
Creation of a zymogen.
Nature structural biology 2003;10(2):115-9.
2003: Marcia C Haigis; Ronald T Raines
Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway.
Journal of cell science 2003;116(Pt 2):313-24.
2002: Sang-Hyun Park; Ronald T Raines
Genetic screen to dissect protein-protein interactions: ribonuclease inhibitor-ribonuclease A as a model system.
Methods (San Diego, Calif.) 2002;28(3):346-52.
2002: Ulrich Arnold; Matthew P Hinderaker; Bradley Nilsson; Bayard R Huck; Samuel H Gellman; Ronald T Raines
Protein prosthesis: a semisynthetic enzyme with a beta-peptide reverse turn.
Journal of the American Chemical Society 2002;124(29):8522-3.
2002: Matthew B Soellner; Bradley Nilsson; Ronald T Raines
Staudinger ligation of alpha-azido acids retains stereochemistry.
The Journal of organic chemistry 2002;67(14):4993-6.
2002: Richele L Abel; Marcia C Haigis; Chiwook Park; Ronald T Raines
Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein.
Analytical biochemistry 2002;306(1):100-7.
2002: Ulrich Arnold; Matthew P Hinderaker; Ronald T Raines
Semisynthesis of ribonuclease A using intein-mediated protein ligation.
TheScientificWorldJournal 2002;2():1823-7.
2002: Marcia C Haigis; Erin L Kurten; Richele L Abel; Ronald T Raines
KFERQ sequence in ribonuclease A-mediated cytotoxicity.
The Journal of biological chemistry 2002;277(13):11576-81.
2002: Michele DeRider; Steven J Wilkens; Michael J Waddell; Lynn E Bretscher; Frank Weinhold; Ronald T Raines; John Lute Markley
Collagen stability: insights from NMR spectroscopic and hybrid density functional computational investigations of the effect of electronegative substituents on prolyl ring conformations.
Journal of the American Chemical Society 2002;124(11):2497-505.
2002: Cara L Jenkins; Ronald T Raines
Insights on the conformational stability of collagen.
Natural product reports 2002;19(1):49-59.
2002: Peter A Leland; Kristine E Staniszewski; Chiwook Park; Bradley R Kelemen; Ronald T Raines
The ribonucleolytic activity of angiogenin.
Biochemistry 2002;41(4):1343-50.
2002: Naoki Umezawa; Michael A Gelman; Marcia C Haigis; Ronald T Raines; Samuel H Gellman
Translocation of a beta-peptide across cell membranes.
Journal of the American Chemical Society 2002;124(3):368-9.
2002: Robert J Hondal; Ronald T Raines
Semisynthesis of proteins containing selenocysteine.
Methods in enzymology 2002;347():70-83.
2001: Chiwook Park; Ronald T Raines
Quantitative analysis of the effect of salt concentration on enzymatic catalysis.
Journal of the American Chemical Society 2001;123(46):11472-9.
2001: Peter A Leland; Kristine E Staniszewski; BM Kim; Ronald T Raines
Endowing human pancreatic ribonuclease with toxicity for cancer cells.
The Journal of biological chemistry 2001;276(46):43095-102.
2001: Chiwook Park; Ronald T Raines
Adjacent cysteine residues as a redox switch.
Protein engineering 2001;14(11):939-42.
2001: TA Klink; AM Vicentini; Jan Hofsteenge; Ronald T Raines
High-level soluble production and characterization of porcine ribonuclease inhibitor.
Protein expression and purification 2001;22(2):174-9.
2001: Elizabeth A Kersteen; Ronald T Raines
Contribution of tertiary amides to the conformational stability of collagen triple helices.
Biopolymers 2001;59(1):24-8.
2001: Robert J Hondal; Bradley Nilsson; Ronald T Raines
Selenocysteine in native chemical ligation and expressed protein ligation.
Journal of the American Chemical Society 2001;123(21):5140-1.
2001: Peter A Leland; Ronald T Raines
Cancer chemotherapy--ribonucleases to the rescue.
Chemistry & biology 2001;8(5):405-13.
2001: Chiwook Park; LW Schultz; Ronald T Raines
Contribution of the active site histidine residues of ribonuclease A to nucleic acid binding.
Biochemistry 2001;40(16):4949-56.
2001: Lynn E Bretscher; Cara L Jenkins; K M Taylor; Michele DeRider; Ronald T Raines
Conformational stability of collagen relies on a stereoelectronic effect.
Journal of the American Chemical Society 2001;123(4):777-8.
2001: Bradley Nilsson; Laura L Kiessling; Ronald T Raines
High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide.
Organic letters 2001;3(1):9-12.
2001: Chiwook Park; Bradley R Kelemen; TA Klink; Rozamond Y Sweeney; M A Behlke; S R Eubanks; Ronald T Raines
Fast, facile, hypersensitive assays for ribonucleolytic activity.
Methods in enzymology 2001;341():81-94.
2000: Bradley R Kelemen; LW Schultz; Rozamond Y Sweeney; Ronald T Raines
Excavating an active site: the nucleobase specificity of ribonuclease A.
Biochemistry 2000;39(47):14487-94.
2000: Rozamond Y Sweeney; Bradley R Kelemen; Kenneth J Woycechowsky; Ronald T Raines
A highly active immobilized ribonuclease.
Analytical biochemistry 2000;286(2):312-4.
2000: Chiwook Park; Ronald T Raines
Dimer formation by a "monomeric" protein.
Protein science : a publication of the Protein Society 2000;9(10):2026-33.
2000: Kenneth J Woycechowsky; Ronald T Raines
Native disulfide bond formation in proteins.
Current opinion in chemical biology 2000;4(5):533-9.
2000: J M Messmore; Ronald T Raines
Decavanadate inhibits catalysis by ribonuclease A.
Archives of biochemistry and biophysics 2000;381(1):25-30.
2000: Peter A Leland; Kristine E Staniszewski; B Kim; Ronald T Raines
A synapomorphic disulfide bond is critical for the conformational stability and cytotoxicity of an amphibian ribonuclease.
FEBS letters 2000;477(3):203-7.
2000: Bradley Nilsson; Laura L Kiessling; Ronald T Raines
Staudinger ligation: a peptide from a thioester and azide.
Organic letters 2000;2(13):1939-41.
2000: T A Klink; Ronald T Raines
Conformational stability is a determinant of ribonuclease A cytotoxicity.
The Journal of biological chemistry 2000;275(23):17463-7.
2000: J M Messmore; SK Holmgren; J E Grilley; Ronald T Raines
Sulfur shuffle: modulating enzymatic activity by thiol-disulfide interchange.
Bioconjugate chemistry 2000;11(3):408-13.
2000: Lynn E Bretscher; Richele L Abel; Ronald T Raines
A ribonuclease A variant with low catalytic activity but high cytotoxicity.
The Journal of biological chemistry 2000;275(14):9893-6.
2000: Chiwook Park; Ronald T Raines
Origin of the 'inactivation' of ribonuclease A at low salt concentration.
FEBS letters 2000;468(2-3):199-202.
2000: Ronald T Raines; M McCormick; T R Van Oosbree; R C Mierendorf
The S.Tag fusion system for protein purification.
Methods in enzymology 2000;326():362-76.
2000: TA Klink; Kenneth J Woycechowsky; K M Taylor; Ronald T Raines
Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A.
European journal of biochemistry / FEBS 2000;267(2):566-72.
1999: S J Mannino; Cara L Jenkins; Ronald T Raines
Chemical mechanism of DNA cleavage by the homing endonuclease I-PpoI.
Biochemistry 1999;38(49):16178-86.
1999: Kenneth J Woycechowsky; K D Wittrup; Ronald T Raines
A small-molecule catalyst of protein folding in vitro and in vivo.
Chemistry & biology 1999;6(12):871-9.
1999: Bradley R Kelemen; TA Klink; M A Behlke; S R Eubanks; Peter A Leland; Ronald T Raines
Hypersensitive substrate for ribonucleases.
Nucleic acids research 1999;27(18):3696-701.
1999: LW Schultz; PT Chivers; Ronald T Raines
The CXXC motif: crystal structure of an active-site variant of Escherichia coli thioredoxin.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 9):1533-8.
1999: Bradley R Kelemen; Ronald T Raines
Extending the limits to enzymatic catalysis: diffusion of ribonuclease A in one dimension.
Biochemistry 1999;38(17):5302-7.
1999: DJ Quirk; Ronald T Raines
His ... Asp catalytic dyad of ribonuclease A: histidine pKa values in the wild-type, D121N, and D121A enzymes.
Biophysical journal 1999;76(3):1571-9.
1999: BM Kim; LW Schultz; Ronald T Raines
Variants of ribonuclease inhibitor that resist oxidation.
Protein science : a publication of the Protein Society 1999;8(2):430-4.
1999: SK Holmgren; Lynn E Bretscher; K M Taylor; Ronald T Raines
A hyperstable collagen mimic.
Chemistry & biology 1999;6(2):63-70.
1998: DJ Quirk; Chiwook Park; J E Thompson; Ronald T Raines
His...Asp catalytic dyad of ribonuclease A: conformational stability of the wild-type, D121N, D121A, and H119A enzymes.
Biochemistry 1998;37(51):17958-64.
1998: BM Fisher; J E Grilley; Ronald T Raines
A new remote subsite in ribonuclease A.
The Journal of biological chemistry 1998;273(51):34134-8.
1998: BM Fisher; LW Schultz; Ronald T Raines
Coulombic effects of remote subsites on the active site of ribonuclease A.
Biochemistry 1998;37(50):17386-401.
1998: S Kothandaraman; M C Hebert; Ronald T Raines; Max L Nibert
No role for pepstatin-A-sensitive acidic proteinases in reovirus infections of L or MDCK cells.
Virology 1998;251(2):264-72.
1998: Peter A Leland; LW Schultz; BM Kim; Ronald T Raines
Ribonuclease A variants with potent cytotoxic activity.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10407-12.
1998: BM Fisher; J H Ha; Ronald T Raines
Coulombic forces in protein-RNA interactions: binding and cleavage by ribonuclease A and variants at Lys7, Arg10, and Lys66.
Biochemistry 1998;37(35):12121-32.
1998: LW Schultz; S R Hargraves; TA Klink; Ronald T Raines
Structure and stability of the P93G variant of ribonuclease A.
Protein science : a publication of the Protein Society 1998;7(7):1620-5.
1998: LW Schultz; DJ Quirk; Ronald T Raines
His...Asp catalytic dyad of ribonuclease A: structure and function of the wild-type, D121N, and D121A enzymes.
Biochemistry 1998;37(25):8886-98.
1998: P K Wittmayer; J L McKenzie; Ronald T Raines
Degenerate DNA recognition by I-PpoI endonuclease.
Gene 1998;206(1):11-21.
1997: PT Chivers; Ronald T Raines
General acid/base catalysis in the active site of Escherichia coli thioredoxin.
Biochemistry 1997;36(50):15810-6.
1997: PT Chivers; Kenneth E Prehoda; Brian F Volkman; B M Kim; John Lute Markley; Ronald T Raines
Microscopic pKa values of Escherichia coli thioredoxin.
Biochemistry 1997;36(48):14985-91.
1997: S H Park; Ronald T Raines
Green fluorescent protein as a signal for protein-protein interactions.
Protein science : a publication of the Protein Society 1997;6(11):2344-9.
1997: M C Laboissière; Stephen L. Sturley; Ronald T Raines
Protein disulfide isomerase in spore germination and cell division.
Biological chemistry 1997;378(5):431-7.
1997: PT Chivers; Kenneth E Prehoda; Ronald T Raines
The CXXC motif: a rheostat in the active site.
Biochemistry 1997;36(14):4061-6.
1996: Josef Soucek; I Marinov; Jirí Benes; Ivan Hilgert; Josef Matousek; Ronald T Raines
Immunosuppressive activity of bovine seminal ribonuclease and its mode of action.
Immunobiology 1996;195(3):271-85.
1996: E S Eberhardt; P K Wittmayer; B M Templer; Ronald T Raines
Contribution of a tyrosine side chain to ribonuclease A catalysis and stability.
Protein science : a publication of the Protein Society 1996;5(8):1697-703.
1996: PT Chivers; M C Laboissière; Ronald T Raines
The CXXC motif: imperatives for the formation of native disulfide bonds in the cell.
The EMBO journal 1996;15(11):2659-67.
1996: Marc Ribó; S B delCardayré; Ronald T Raines; Rafael de Llorens; Claudi M Cuchillo
Production of human pancreatic ribonuclease in Saccharomyces cerevisiae and Escherichia coli.
Protein expression and purification 1996;7(3):253-61.
1996: P K Wittmayer; Ronald T Raines
Substrate binding and turnover by the highly specific I-PpoI endonuclease.
Biochemistry 1996;35(3):1076-83.
1995: J S Kim; Josef Soucek; Josef Matousek; Ronald T Raines
Mechanism of ribonuclease cytotoxicity.
The Journal of biological chemistry 1995;270(52):31097-102.
1995: M C Laboissiere; Stephen L. Sturley; Ronald T Raines
The essential function of protein-disulfide isomerase is to unscramble non-native disulfide bonds.
The Journal of biological chemistry 1995;270(47):28006-9.
1995: M C Laboissière; PT Chivers; Ronald T Raines
Production of rat protein disulfide isomerase in Saccharomyces cerevisiae.
Protein expression and purification 1995;6(5):700-6.
1995: S B delCardayré; Ronald T Raines
A residue to residue hydrogen bond mediates the nucleotide specificity of ribonuclease A.
Journal of molecular biology 1995;252(3):328-36.
1995: Ronald T Raines; M P Toscano; D M Nierengarten; J H Ha; R Auerbach
Replacing a surface loop endows ribonuclease A with angiogenic activity.
The Journal of biological chemistry 1995;270(29):17180-4.
1995: J S Kim; Josef Soucek; Josef Matousek; Ronald T Raines
Catalytic activity of bovine seminal ribonuclease is essential for its immunosuppressive and other biological activities.
The Biochemical journal 1995;308 ( Pt 2)():547-50.
1995: J S Kim; Josef Soucek; Josef Matousek; Ronald T Raines
Structural basis for the biological activities of bovine seminal ribonuclease.
The Journal of biological chemistry 1995;270(18):10525-30.
1995: S B delCardayré; Marc Ribó; E M Yokel; DJ Quirk; W J Rutter; Ronald T Raines
Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11.
Protein engineering 1995;8(3):261-73.
1995: J S Kim; Ronald T Raines
Dibromobimane as a fluorescent crosslinking reagent.
Analytical biochemistry 1995;225(1):174-6.
1995: S B delCardayré; Ronald T Raines
The extent to which ribonucleases cleave ribonucleic acid.
Analytical biochemistry 1995;225(1):176-8.
1994: N Panasik; E S Eberhardt; A S Edison; D R Powell; Ronald T Raines
Inductive effects on the structure of proline residues.
International journal of peptide and protein research 1994;44(3):262-9.
1994: J S Kim; Ronald T Raines
A misfolded but active dimer of bovine seminal ribonuclease.
European journal of biochemistry / FEBS 1994;224(1):109-14.
1994: J E Thompson; F D Venegas; Ronald T Raines
Energetics of catalysis by ribonucleases: fate of the 2',3'-cyclic phosphodiester intermediate.
Biochemistry 1994;33(23):7408-14.
1994: S B delCardayré; Ronald T Raines
Structural determinants of enzymatic processivity.
Biochemistry 1994;33(20):6031-7.
1993: J S Kim; Ronald T Raines
Bovine seminal ribonuclease produced from a synthetic gene.
The Journal of biological chemistry 1993;268(23):17392-6.
1993: C B Taylor; P A Bariola; S B delCardayré; Ronald T Raines; Pamela J Green
RNS2: a senescence-associated RNase of Arabidopsis that diverged from the S-RNases before speciation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5118-22.
1993: J S Kim; Ronald T Raines
Ribonuclease S-peptide as a carrier in fusion proteins.
Protein science : a publication of the Protein Society 1993;2(3):348-56.