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Jon Rainier

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Molecular Structure

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Ciguatera Poisoning

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Publications

TOP 3
Ivan Kopljar; Alain J Labro; Jon D Rainier; Tessa de Block; Jan Tytgat; Dirk J Snyders
The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state.
Jin Wang; Vyacheslav Boyarskikh; Jon D Rainier
Vinyl diazophosphonates as precursors to quaternary substituted indolines and cyclopentenes.
Vinson R Espejo; Xi-Bo Li; Jon D Rainier
Cyclopropylazetoindolines as precursors to C(3)-quaternary-substituted indolines.

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All Publications

2013: Ivan Kopljar; Alain J Labro; Jon D Rainier; Tessa de Block; Jan Tytgat; Dirk J Snyders
The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state.
The Journal of general physiology 2013;141(3):359-69.
2011: Jin Wang; Vyacheslav Boyarskikh; Jon D Rainier
Vinyl diazophosphonates as precursors to quaternary substituted indolines and cyclopentenes.
Organic letters 2011;13(4):700-2.
2010: Vinson R Espejo; Xi-Bo Li; Jon D Rainier
Cyclopropylazetoindolines as precursors to C(3)-quaternary-substituted indolines.
Journal of the American Chemical Society 2010;132(24):8282-4.
2010: Vinson R Espejo; Jon D Rainier
Total synthesis of kapakahine E and F.
Organic letters 2010;12(9):2154-7.
2009: Jie Zhou; Jon D Rainier
Olefinic-amide and olefinic-lactam cyclizations.
Organic letters 2009;11(16):3774-6.
2009: Ivan Kopljar; Alain J Labro; Eva Cuypers; Henry W B Johnson; Jon D Rainier; Jan Tytgat; Dirk J Snyders
A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9896-901.
2009: John C Rohanna; Jon D Rainier
Olefinic-lactone cyclizations to macrocycles.
Organic letters 2009;11(2):493-5.
2009: Yuan Zhang; Jon D Rainier
Two-directional olefinic-ester ring-closing metathesis using reduced Ti alkylidenes. A rapid entry into polycyclic ether skeletons.
Organic letters 2009;11(1):237-9.
2008: Vinson R Espejo; Jon D Rainier
An expeditious synthesis of C(3)-N(1') heterodimeric indolines.
Journal of the American Chemical Society 2008;130(39):12894-5.
2008: Zhengyu Cao; Joju George; William H Gerwick; Daniel G Baden; Jon D Rainier; Thomas F Murray
Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons.
The Journal of pharmacology and experimental therapeutics 2008;326(2):604-13.
2008: Eva Cuypers; Yousra Abdel-Mottaleb; Ivan Kopljar; Jon D Rainier; Adam L Raes; Dirk J Snyders; Jan Tytgat
Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels.
Toxicon : official journal of the International Society on Toxinology 2008;51(6):974-83.
2008: Clement Osei Akoto; Jon D Rainier
Harnessing glycal-epoxide rearrangements: the generation of the AB, EF, and IJ rings of adriatoxin.
Angewandte Chemie (International ed. in English) 2008;47(42):8055-8.
2008: Vyacheslav Boyarskikh; Abijah Nyong; Jon D Rainier
Highly diastereoselective sulfonium ylide rearrangements to quaternary substituted indolines.
Angewandte Chemie (International ed. in English) 2008;47(29):5374-7.
2007: Karthik Iyer; Jon D Rainier
Olefinic ester and diene ring-closing metathesis using a reduced titanium alkylidene.
Journal of the American Chemical Society 2007;129(42):12604-5.
2007: Keith T LePage; Jon D Rainier; Henry W B Johnson; Daniel G Baden; Thomas F Murray
Gambierol acts as a functional antagonist of neurotoxin site 5 on voltage-gated sodium channels in cerebellar granule neurons.
The Journal of pharmacology and experimental therapeutics 2007;323(1):174-9.
2007: Eva Cuypers; Angel Yanagihara; Jon D Rainier; Jan Tytgat
TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning.
Biochemical and biophysical research communications 2007;361(1):214-7.
2007: Scott W Roberts; Jon D Rainier
Synthesis of an A-E gambieric acid subunit with use of a C-glycoside centered strategy.
Organic letters 2007;9(11):2227-30.
2006: Anita M Orendt; Scott W Roberts; Jon D Rainier
The role of asynchronous bond formation in the diastereoselective epoxidation of cyclic enol ethers: a density functional theory study.
The Journal of organic chemistry 2006;71(15):5565-73.
2006: Amir Sabahi; Alexei Novikov; Jon D Rainier
2-thioindoles as precursors to spiro-fused indolines: synthesis of (+/-)-dehaloperophoramidine.
Angewandte Chemie (International ed. in English) 2006;45(26):4317-20.
2006: Henry W B Johnson; Utpal Majumder; Jon D Rainier
Total synthesis of gambierol: subunit coupling and completion.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(6):1747-53.
2006: Utpal Majumder; Jason M. Cox; Henry W B Johnson; Jon D Rainier
Total synthesis of gambierol: the generation of the A-C and F-H subunits by using a C-glycoside centered strategy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(6):1736-46.
2006: Zhuqing Liu; Jon D Rainier
Ring-opening/ring-closing metathesis (RORCM) reactions of 7-Azanorbornene derivatives. An entry into perhydroindolines.
Organic letters 2006;8(3):459-62.
2005: Scott W Roberts; Jon D Rainier
Substitution and remote protecting group influence on the oxidation/addition of alpha-substituted 1,2-anhydroglycosides: a novel entry into C-ketosides.
Organic letters 2005;7(6):1141-4.
2005: Henry W B Johnson; Utpal Majumder; Jon D Rainier
The total synthesis of gambierol.
Journal of the American Chemical Society 2005;127(3):848-9.
2005: Abijah M Nyong; Jon D Rainier
The diastereoselective synthesis of quaternary substituted thioindolines from sulfur ylide intermediates.
The Journal of organic chemistry 2005;70(2):746-8.
2005: Zhuqing Liu; Jon D Rainier
Regioselective ring-opening/cross-metathesis reactions of norbornene derivatives with electron-rich olefins.
Organic letters 2005;7(1):131-3.
2004: G Mahika Weeresakare; Zhuqing Liu; Jon D Rainier
Highly regioselective ring-opening/cross-metathesis reactions of 2-sulfonylnorbornene derivatives.
Organic letters 2004;6(10):1625-7.
2003: Amos B Smith; Naoki Kanoh; Haruaki Ishiyama; Noriaki Minakawa; Jon D Rainier; Richard A Hartz; Young Shin Cho; Haifeng Cui; William H Moser
Tremorgenic indole alkaloids. The total synthesis of (-)-penitrem D.
Journal of the American Chemical Society 2003;125(27):8228-37.
2003: Utpal Majumder; Jason M. Cox; Jon D Rainier
Synthesis of an F-H gambierol subunit using a C-glycoside-centered strategy.
Organic letters 2003;5(6):913-6.
2003: Alexei V Novikov; Abigail R Kennedy; Jon D Rainier
Sulfur ylide-initiated thio-claisen rearrangements. The synthesis of highly substituted indolines.
The Journal of organic chemistry 2003;68(3):993-6.
2001: Jason M. Cox; Jon D Rainier
C-glycosides to fused polycyclic ethers. An efficient entry into the A-D ring system of gambierol.
Organic letters 2001;3(18):2919-22.
2001: Abigail R Kennedy; M H Taday; Jon D Rainier
The use of sulfur ylides in the synthesis of substituted indoles.
Organic letters 2001;3(15):2407-9.
2001: Jon D Rainier; S P Allwein; Jason M. Cox
C-glycosides to fused polycyclic ethers. A formal synthesis of (+/-)-hemibrevetoxin B.
The Journal of organic chemistry 2001;66(4):1380-6.
2000: Jon D Rainier; Abigail R Kennedy
Cascades to substituted indoles.
The Journal of organic chemistry 2000;65(19):6213-6.
2000: Jon D Rainier; Jason M. Cox
Aluminum- and boron-mediated c-glycoside synthesis from 1,2-anhydroglycosides.
Organic letters 2000;2(17):2707-9.
2000: Jon D Rainier; S P Allwein; Jason M. Cox
A highly efficient synthesis of the hemibrevetoxin B ring system.
Organic letters 2000;2(2):231-4.
1999: Amos B Smith; N Kanoh; N Minakawa; Jon D Rainier; F R Blase; R A Hartz
Tremorgenic indole alkaloids. Studies directed toward the assembly of the A, F, and I rings of penitrem D: observation of an unexpected stereochemical outcome.
Organic letters 1999;1(8):1263-6.
1999: Jon D Rainier; Q Xu
A novel anionic condensation, fragmentation, and elimination reaction of bicyclo[2.2.1]heptenone ring systems.
Organic letters 1999;1(1):27-9.