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Bheeshma Rajagopalan

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Bheeshma Rajagopalan; Jane M Francis; Fraser Cooke; L V Prasad Korlipara; Andrew M Blamire; Anthony H V Schapira; Jason Madan; Stefan Neubauer; J Mark Cooper
Analysis of the factors influencing the cardiac phenotype in Friedreich's ataxia.
Jenifer G Crilley; David Bendahan; Ernest A Boehm; Peter Styles; Bheeshma Rajagopalan; Paul Wordsworth; Kieran Clarke
Investigation of muscle bioenergetics in the Marfan syndrome indicates reduced metabolic efficiency.
Sarah J Tabrizi; Andrew M Blamire; David Manners; Bheeshma Rajagopalan; Peter Styles; Anthony H V Schapira; Thomas T Warner
High-dose creatine therapy for Huntington disease: a 2-year clinical and MRS study.

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2010: Bheeshma Rajagopalan; Jane M Francis; Fraser Cooke; L V Prasad Korlipara; Andrew M Blamire; Anthony H V Schapira; Jason Madan; Stefan Neubauer; J Mark Cooper
Analysis of the factors influencing the cardiac phenotype in Friedreich's ataxia.
Movement disorders : official journal of the Movement Disorder Society 2010;25(7):846-52.
2007: Jenifer G Crilley; David Bendahan; Ernest A Boehm; Peter Styles; Bheeshma Rajagopalan; Paul Wordsworth; Kieran Clarke
Investigation of muscle bioenergetics in the Marfan syndrome indicates reduced metabolic efficiency.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2007;9(4):709-17.
2005: Sarah J Tabrizi; Andrew M Blamire; David Manners; Bheeshma Rajagopalan; Peter Styles; Anthony H V Schapira; Thomas T Warner
High-dose creatine therapy for Huntington disease: a 2-year clinical and MRS study.
Neurology 2005;64(9):1655-6.
2005: Paul E Hart; Raffaele Lodi; Bheeshma Rajagopalan; Jane L Bradley; Jenifer G Crilley; Christopher Turner; Andrew M Blamire; David Manners; Peter Styles; Anthony H V Schapira; J Mark Cooper
Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up.
Archives of neurology 2005;62(4):621-6.
2004: Raffaele Lodi; Bheeshma Rajagopalan; Andrew M Blamire; Jenifer G Crilley; Peter Styles; Patrick F Chinnery
Abnormal cardiac energetics in patients carrying the A3243G mtDNA mutation measured in vivo using phosphorus MR spectroscopy.
Biochimica et biophysica acta 2004;1657(2-3):146-50.
2004: Pablo Goetz; Andrew M Blamire; Bheeshma Rajagopalan; Tom Cadoux-Hudson; Duncan Young; Peter Styles
Increase in apparent diffusion coefficient in normal appearing white matter following human traumatic brain injury correlates with injury severity.
Journal of neurotrauma 2004;21(6):645-54.
2004: F J Cooke; Andrew M Blamire; David Manners; Peter Styles; Bheeshma Rajagopalan
Quantitative proton magnetic resonance spectroscopy of the cervical spinal cord.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;51(6):1122-8.
2004: E C Vaux; D J Taylor; P Altmann; Bheeshma Rajagopalan; K Graham; R Cooper; Y Bonomo; Peter Styles
Effects of carnitine supplementation on muscle metabolism by the use of magnetic resonance spectroscopy and near-infrared spectroscopy in end-stage renal disease.
Nephron. Clinical practice 2004;97(2):c41-8.
2003: Raffaele Lodi; Bheeshma Rajagopalan; Anthony H V Schapira; J Mark Cooper
Cardiac bioenergetics in Friedreich's ataxia.
Annals of neurology 2003;54(4):552; author reply 552-3.
2003: Sarah J Tabrizi; Andrew M Blamire; David Manners; Bheeshma Rajagopalan; Peter Styles; Anthony H V Schapira; Thomas T Warner
Creatine therapy for Huntington's disease: clinical and MRS findings in a 1-year pilot study.
Neurology 2003;61(1):141-2.
2003: Robin G Corkill; Matthew R Garnett; Andrew M Blamire; Bheeshma Rajagopalan; Tom Cadoux-Hudson; Peter Styles
Multi-modal MRI in normal pressure hydrocephalus identifies pre-operative haemodynamic and diffusion coefficient changes in normal appearing white matter correlating with surgical outcome.
Clinical neurology and neurosurgery 2003;105(3):193-202.
2003: Jenifer G Crilley; Ernest A Boehm; Edward Blair; Bheeshma Rajagopalan; Andrew M Blamire; Peter Styles; William J McKenna; Ingegerd Ostman-Smith; Kieran Clarke; Hugh Watkins
Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy.
Journal of the American College of Cardiology 2003;41(10):1776-82.
2002: Raffaele Lodi; Bheeshma Rajagopalan; Jane L Bradley; Doris J Taylor; Jenifer G Crilley; Paul E Hart; Andrew M Blamire; David Manners; Peter Styles; Anthony H V Schapira; J Mark Cooper
Mitochondrial dysfunction in Friedreich's ataxia: from pathogenesis to treatment perspectives.
Free radical research 2002;36(4):461-6.
2002: Andrew M Blamire; Tom Cadoux-Hudson; Bheeshma Rajagopalan
Reversible brain injury in a head-injured patient identified by magnetic resonance imaging and spectroscopy.
British journal of neurosurgery 2002;16(1):48-51.
2001: Raffaele Lodi; Bheeshma Rajagopalan; Andrew M Blamire; J Mark Cooper; C H Davies; Jane L Bradley; Peter Styles; Anthony H V Schapira
Cardiac energetics are abnormal in Friedreich ataxia patients in the absence of cardiac dysfunction and hypertrophy: an in vivo 31P magnetic resonance spectroscopy study.
Cardiovascular research 2001;52(1):111-9.
2001: KA Matyka; Ruth M Dixon; A Mohn; Bheeshma Rajagopalan; E Shmueli; Peter Styles; David D Dunger
Daytime liver glycogen accumulation, measured by 13C magnetic resonance spectroscopy, in young children with Type 1 diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 2001;18(8):659-62.
2001: Matthew R Garnett; Andrew M Blamire; Robin G Corkill; Bheeshma Rajagopalan; J D Young; Tom Cadoux-Hudson; Peter Styles
Abnormal cerebral blood volume in regions of contused and normal appearing brain following traumatic brain injury using perfusion magnetic resonance imaging.
Journal of neurotrauma 2001;18(6):585-93.
2001: Raffaele Lodi; Paul E Hart; Bheeshma Rajagopalan; Doris J Taylor; Jenifer G Crilley; Jane L Bradley; Andrew M Blamire; David Manners; Peter Styles; Anthony H V Schapira; J Mark Cooper
Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia.
Annals of neurology 2001;49(5):590-6.
2001: Matthew R Garnett; Robin G Corkill; Andrew M Blamire; Bheeshma Rajagopalan; David Manners; J D Young; Peter Styles; Tom Cadoux-Hudson
Altered cellular metabolism following traumatic brain injury: a magnetic resonance spectroscopy study.
Journal of neurotrauma 2001;18(3):231-40.
2000: Jenifer G Crilley; Ernest A Boehm; Bheeshma Rajagopalan; Andrew M Blamire; Peter Styles; F Muntoni; David Hilton-Jones; Kieran Clarke
Magnetic resonance spectroscopy evidence of abnormal cardiac energetics in Xp21 muscular dystrophy.
Journal of the American College of Cardiology 2000;36(6):1953-8.
2000: Andrew M Blamire; Daniel Anthony; Bheeshma Rajagopalan; Nicola R Sibson; V Hugh Perry; Peter Styles
Interleukin-1beta -induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(21):8153-9.
2000: Matthew R Garnett; Andrew M Blamire; Robin G Corkill; Tom Cadoux-Hudson; Bheeshma Rajagopalan; Peter Styles
Early proton magnetic resonance spectroscopy in normal-appearing brain correlates with outcome in patients following traumatic brain injury.
Brain : a journal of neurology 2000;123 ( Pt 10)():2046-54.
2000: Matthew R Garnett; Andrew M Blamire; Bheeshma Rajagopalan; Peter Styles; Tom Cadoux-Hudson
Evidence for cellular damage in normal-appearing white matter correlates with injury severity in patients following traumatic brain injury: A magnetic resonance spectroscopy study.
Brain : a journal of neurology 2000;123 ( Pt 7)():1403-9.
2000: David J Propper; Nicola C Levitt; K O'Byrne; Jeremy P Braybrooke; Denis C Talbot; Trivadi Ganesan; Campbell H Thompson; Bheeshma Rajagopalan; T J Littlewood; Ruth M Dixon; Adrian L Harris
Phase II study of the oxygen saturation curve left shifting agent BW12C in combination with the hypoxia activated drug mitomycin C in advanced colorectal cancer.
British journal of cancer 2000;82(11):1776-82.
2000: Z Domingo; J K Bradley; Andrew M Blamire; K Brindle; Peter Styles; Bheeshma Rajagopalan
Diffusion weighted imaging and magnetic resonance spectroscopy in a low flow ischaemia model due to endothelin induced vasospasm.
NMR in biomedicine 2000;13(3):154-62.
1999: S Adamopoulos; Graham Kemp; Campbell H Thompson; Leonard F Arnolda; F Brunotte; J R Stratton; George K Radda; Bheeshma Rajagopalan; D T Kremastinos; A J Coats
The time course of haemodynamic, autonomic and skeletal muscle metabolic abnormalities following first extensive myocardial infarction in man.
Journal of molecular and cellular cardiology 1999;31(10):1913-26.
1999: Andrew M Blamire; Bheeshma Rajagopalan; George K Radda
Measurement of myocardial pH by saturation transfer in man.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1999;41(1):198-203.
1998: M A Conway; Paul A Bottomley; Ronald Ouwerkerk; George K Radda; Bheeshma Rajagopalan
Mitral regurgitation: impaired systolic function, eccentric hypertrophy, and increased severity are linked to lower phosphocreatine/ATP ratios in humans.
Circulation 1998;97(17):1716-23.
1997: Campbell H Thompson; Graham Kemp; D J Taylor; Michael Conway; Bheeshma Rajagopalan; A O'Donoghue; Peter Styles; W J McKenna; George K Radda
Abnormal skeletal muscle bioenergetics in familial hypertrophic cardiomyopathy.
Heart (British Cardiac Society) 1997;78(2):177-81.
1996: Graham Kemp; Campbell H Thompson; J R Stratton; F Brunotte; M Conway; Stamatis Adamopoulos; L Arnolda; George K Radda; Bheeshma Rajagopalan
Abnormalities in exercising skeletal muscle in congestive heart failure can be explained in terms of decreased mitochondrial ATP synthesis, reduced metabolic efficiency, and increased glycogenolysis.
Heart (British Cardiac Society) 1996;76(1):35-41.
1995: J G Rowe; N Soper; Ronald Ouwerkerk; R S Kerr; George K Radda; Bheeshma Rajagopalan
Delayed ischaemia after subarachnoid haemorrhage: a role for small vessel changes.
Journal of neurology, neurosurgery, and psychiatry 1995;59(4):451-2.
1995: J G Rowe; James V Byrne; Andrew Molyneux; Bheeshma Rajagopalan
Haemodynamic consequences of embolizing aneurysms: a transcranial Doppler study.
British journal of neurosurgery 1995;9(6):749-57.
1994: Campbell H Thompson; Graham Kemp; Bheeshma Rajagopalan; George K Radda
Metabolic abnormalities in skeletal muscle after myocardial infarction in the rat.
Clinical science (London, England : 1979) 1994;87(4):403-6.
1994: Ruth M Dixon; Peter Styles; F N al-Refaie; Graham Kemp; S M Donohue; Beatrix Wonke; A Victor Hoffbrand; G K Radda; Bheeshma Rajagopalan
Assessment of hepatic iron overload in thalassemic patients by magnetic resonance spectroscopy.
Hepatology (Baltimore, Md.) 1994;19(4):904-10.
1994: N S Brooke; Ronald Ouwerkerk; C B Adams; George K Radda; J G Ledingham; Bheeshma Rajagopalan
Phosphorus-31 magnetic resonance spectra reveal prolonged intracellular acidosis in the brain following subarachnoid hemorrhage.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1903-7.
1994: Campbell H Thompson; Graham Kemp; P R Barnes; Bheeshma Rajagopalan; Peter Styles; Doris J Taylor; George K Radda
Uraemic muscle metabolism at rest and during exercise.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1994;9(11):1600-5.
1993: Graham Kemp; Doris J Taylor; Campbell H Thompson; Linda Hands; Bheeshma Rajagopalan; Peter Styles; George K Radda
Quantitative analysis by 31P magnetic resonance spectroscopy of abnormal mitochondrial oxidation in skeletal muscle during recovery from exercise.
NMR in biomedicine 1993;6(5):302-10.
1993: Campbell H Thompson; Graham Kemp; Doris J Taylor; George K Radda; Bheeshma Rajagopalan
No evidence of mitochondrial abnormality in skeletal muscle of patients with iron-deficient anaemia.
Journal of internal medicine 1993;234(2):149-54.
1993: Campbell H Thompson; Y Anderson; D H Jagasia; George K Radda; Bheeshma Rajagopalan
Effect of tri-iodothyronine administration on skeletal muscle intracellular pH in the rat.
Clinical science (London, England : 1979) 1993;84(6):645-9.
1993: Graham Kemp; Campbell H Thompson; Doris J Taylor; Linda Hands; Bheeshma Rajagopalan; George K Radda
Quantitative analysis of defects of mitochondrial oxidation during recovery from exercise.
Biochemical Society transactions 1993;21(2):176S.
1993: Campbell H Thompson; R J Davies; Graham Kemp; Doris J Taylor; George K Radda; Bheeshma Rajagopalan
Skeletal muscle metabolism during exercise and recovery in patients with respiratory failure.
Thorax 1993;48(5):486-90.
1993: Campbell H Thompson; Y S Green; J G Ledingham; George K Radda; Bheeshma Rajagopalan
The effect of iron deficiency on skeletal muscle metabolism of the rat.
Acta physiologica Scandinavica 1993;147(1):85-90.
1993: Campbell H Thompson; Graham Kemp; Doris J Taylor; J G Ledingham; George K Radda; Bheeshma Rajagopalan
Effect of chronic uraemia on skeletal muscle metabolism in man.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1993;8(3):218-22.
1992: E J Murphy; T E Bates; S R Williams; T Watson; Kevin M Brindle; Bheeshma Rajagopalan; George K Radda
Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths.
Biochimica et biophysica acta 1992;1111(1):51-8.
1992: Ruth M Dixon; P W Angus; Bheeshma Rajagopalan; G K Radda
31P magnetic resonance spectroscopy detects a functional abnormality in liver metabolism after acetaminophen poisoning.
Hepatology (Baltimore, Md.) 1992;16(4):943-8.
1992: Graham Kemp; Doris J Taylor; George K Radda; Bheeshma Rajagopalan
Bio-energetic changes in human gastrocnemius muscle 1-2 days after strenuous exercise.
Acta physiologica Scandinavica 1992;146(1):11-4.
1992: B Kalderon; Ruth M Dixon; Bheeshma Rajagopalan; P W Angus; R D Oberhaensli; J E Collins; J V Leonard; George K Radda
A study of galactose intolerance in human and rat liver in vivo by 31P magnetic resonance spectroscopy.
Pediatric research 1992;32(1):39-44.
1992: Doris J Taylor; Bheeshma Rajagopalan; George K Radda
Cellular energetics in hypothyroid muscle.
European journal of clinical investigation 1992;22(5):358-65.
1992: E J Murphy; Kevin M Brindle; C J Rorison; Ruth M Dixon; Bheeshma Rajagopalan; George K Radda
Changes in phosphatidylethanolamine metabolism in regenerating rat liver as measured by 31P-NMR.
Biochimica et biophysica acta 1992;1135(1):27-34.
1991: Tom Cadoux-Hudson; A Kermode; Bheeshma Rajagopalan; D Taylor; A J Thompson; I E Ormerod; W I McDonald; George K Radda
Biochemical changes within a multiple sclerosis plaque in vivo.
Journal of neurology, neurosurgery, and psychiatry 1991;54(11):1004-6.
1991: M A Conway; J Allis; Ronald Ouwerkerk; T Niioka; Bheeshma Rajagopalan; George K Radda
Detection of low phosphocreatine to ATP ratio in failing hypertrophied human myocardium by 31P magnetic resonance spectroscopy.
Lancet 1991;338(8773):973-6.
1991: J Moorcraft; N M Bolas; N K Ives; Ronald Ouwerkerk; J Smyth; Bheeshma Rajagopalan; P L Hope; George K Radda
Global and depth resolved phosphorus magnetic resonance spectroscopy to predict outcome after birth asphyxia.
Archives of disease in childhood 1991;66(10 Spec No):1119-23.
1991: L Arnolda; J Brosnan; Bheeshma Rajagopalan; George K Radda
Skeletal muscle metabolism in heart failure in rats.
The American journal of physiology 1991;261(2 Pt 2):H434-42.
1991: Ruth M Dixon; P W Angus; Bheeshma Rajagopalan; George K Radda
Abnormal phosphomonoester signals in 31P MR spectra from patients with hepatic lymphoma. A possible marker of liver infiltration and response to chemotherapy.
British journal of cancer 1991;63(6):953-8.
1991: J Moorcraft; N M Bolas; N K Ives; P Sutton; M J Blackledge; Bheeshma Rajagopalan; P L Hope; George K Radda
Spatially localized magnetic resonance spectroscopy of the brains of normal and asphyxiated newborns.
Pediatrics 1991;87(3):273-82.
1991: M A Conway; J D Bristow; M J Blackledge; Bheeshma Rajagopalan; George K Radda
Cardiac metabolism during exercise in healthy volunteers measured by 31P magnetic resonance spectroscopy.
British heart journal 1991;65(1):25-30.
1990: L Arnolda; M Conway; M Dolecki; H Sharif; Bheeshma Rajagopalan; J G Ledingham; P Sleight; George K Radda
Skeletal muscle metabolism in heart failure: a 31P nuclear magnetic resonance spectroscopy study of leg muscle.
Clinical science (London, England : 1979) 1990;79(6):583-9.
1990: J E Seegmiller; Ruth M Dixon; Graham Kemp; P W Angus; T E McAlindon; Paul Dieppe; Bheeshma Rajagopalan; George K Radda
Fructose-induced aberration of metabolism in familial gout identified by 31P magnetic resonance spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8326-30.
1990: Tom Cadoux-Hudson; Bheeshma Rajagopalan; J G Ledingham; George K Radda
Response of the human brain to a hypercapnic acid load in vivo.
Clinical science (London, England : 1979) 1990;79(1):1-3.
1990: Tom Cadoux-Hudson; D Wade; Doris J Taylor; Bheeshma Rajagopalan; J G Ledingham; M Briggs; George K Radda
Persistent metabolic sequelae of severe head injury in humans in vivo.
Acta neurochirurgica 1990;104(1-2):1-7.
1990: P W Angus; Ruth M Dixon; Bheeshma Rajagopalan; N G Ryley; K J Simpson; T J Peters; D P Jewell; George K Radda
A study of patients with alcoholic liver disease by 31P nuclear magnetic resonance spectroscopy.
Clinical science (London, England : 1979) 1990;78(1):33-8.
1990: J E Seegmiller; Ruth M Dixon; Graham Kemp; P W Angus; T E McAlindon; Paul Dieppe; Bheeshma Rajagopalan; George K Radda
An aberration of fructose metabolism in familial gout identified by 31P magnetic resonance spectroscopy of the liver.
Transactions of the Association of American Physicians 1990;103():298-306.
1989: E J Murphy; Bheeshma Rajagopalan; Kevin M Brindle; George K Radda
Phospholipid bilayer contribution to 31P NMR spectra in vivo.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1989;12(2):282-9.
1989: Tom Cadoux-Hudson; M J Blackledge; Bheeshma Rajagopalan; Doris J Taylor; George K Radda
Human primary brain tumour metabolism in vivo: a phosphorus magnetic resonance spectroscopy study.
British journal of cancer 1989;60(3):430-6.
1988: M A Conway; J D Bristow; M J Blackledge; Bheeshma Rajagopalan; George K Radda
Cardiac metabolism during exercise measured by magnetic resonance spectroscopy.
Lancet 1988;2(8612):692.
1988: Bheeshma Rajagopalan; M A Conway; Barrie Massie; George K Radda
Alterations of skeletal muscle metabolism in humans studied by phosphorus 31 magnetic resonance spectroscopy in congestive heart failure.
The American journal of cardiology 1988;62(8):53E-57E.
1988: N M Bolas; Bheeshma Rajagopalan; F Mitsumori; George K Radda
Metabolic changes during experimental cerebral ischemia in hyperglycemic rats, observed by 31P and 1H magnetic resonance spectroscopy.
Stroke; a journal of cerebral circulation 1988;19(5):608-14.
1988: R D Oberhaensli; Bheeshma Rajagopalan; D J Taylor; George K Radda; J E Collins; J V Leonard
Study of liver metabolism in glucose-6-phosphatase deficiency (glycogen storage disease type 1A) by P-31 magnetic resonance spectroscopy.
Pediatric research 1988;23(4):375-80.
1988: Kevin M Brindle; Bheeshma Rajagopalan; D S Williams; J A Detre; E Simplaceanu; C Ho; George K Radda
31P NMR measurements of myocardial pH in vivo.
Biochemical and biophysical research communications 1988;151(1):70-7.
1987: R D Oberhaensli; Bheeshma Rajagopalan; D J Taylor; George K Radda; J E Collins; J V Leonard; H Schwarz; N Herschkowitz
Study of hereditary fructose intolerance by use of 31P magnetic resonance spectroscopy.
Lancet 1987;2(8565):931-4.
1987: M J Blackledge; Bheeshma Rajagopalan; R D Oberhaensli; N M Bolas; P Styles; George K Radda
Quantitative studies of human cardiac metabolism by 31P rotating-frame NMR.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(12):4283-7.
1987: Bheeshma Rajagopalan; M J Blackledge; W J McKenna; N Bolas; George K Radda
Measurement of phosphocreatine to ATP ratio in normal and diseased human heart by 31P magnetic resonance spectroscopy using the rotating frame-depth selection technique.
Annals of the New York Academy of Sciences 1987;508():321-32.