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Srinivasan Rajalakshmi

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Janarthanan Kankesan; Ezio Laconi; Alan Medline; Jake J Thiessen; Victor Ling; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
PSC 833, an inhibitor of P-glycoprotein inhibits 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male Fischer F344 rats.
Janarthanan Kankesan; Ramesh Vanama; Aroon Yusuf; Jake J Thiessen; Victor Ling; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Effect of PSC 833, an inhibitor of P-glycoprotein on N-methyl-N-nitrosourea induced mammary carcinogenesis in rats.
Janarthanan Kankesan; Aroon Yusuf; Ezio Laconi; Ramesh Vanama; Grace Bradley; Jake J Thiessen; Victor Ling; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats.

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All Publications

2006: Janarthanan Kankesan; Ezio Laconi; Alan Medline; Jake J Thiessen; Victor Ling; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
PSC 833, an inhibitor of P-glycoprotein inhibits 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male Fischer F344 rats.
Anticancer research 2006;26(2A):995-9.
2004: Janarthanan Kankesan; Ramesh Vanama; Aroon Yusuf; Jake J Thiessen; Victor Ling; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Effect of PSC 833, an inhibitor of P-glycoprotein on N-methyl-N-nitrosourea induced mammary carcinogenesis in rats.
Carcinogenesis 2004;25(3):425-30.
2003: Janarthanan Kankesan; Aroon Yusuf; Ezio Laconi; Ramesh Vanama; Grace Bradley; Jake J Thiessen; Victor Ling; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats.
Carcinogenesis 2003;24(12):1977-84.
2003: Janarthanan Kankesan; Ramesh Vanama; Richard Renlund; Jake J Thiessen; Victor Ling; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Source of a micro-nutrient in a semi-synthetic basal diet as a causative factor in inducing urinary calculi in rats and its inhibition by PSC 833, a potent inhibitor of P-glycoprotein.
Comparative medicine 2003;53(4):444-7.
2003: Venkatraman Sadanand; Janarthanan Kankesan; Aroon Yusuf; C Stewart; J T Rutka; Jake J Thiessen; V Ling; P M Rao; Srinivasan Rajalakshmi; D S R Sarma
Effect of PSC 833, a potent inhibitor of P-glycoprotein, on the growth of astrocytoma cells in vitro.
Cancer letters 2003;198(1):21-7.
1999: Aroon Yusuf; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Development of resistance during the early stages of experimental liver carcinogenesis.
Carcinogenesis 1999;20(8):1641-4.
1999: Aroon Yusuf; Ezio Laconi; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
The effect of 1/3 partial hepatectomy on the growth of glutathione S-transferase positive foci.
Carcinogenesis 1999;20(6):1143-5.
1999: S Manjeshwar; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in normal rat liver in vivo.
Molecular carcinogenesis 1999;24(3):188-96.
1998: S Vasudevan; Ezio Laconi; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma; Gianluigi La Piana; Emilia Fransvea; Domenico Marzulli; Nicola Elio Lofrumento
Cycloheximide sensitivity of orotic acid biosynthesis induced by ammonia and glycine administration.
European journal of biochemistry / FEBS 1998;251(3):597-604.
1997: Ezio Laconi; Aroon Yusuf; A R Jahangir; Sergio Laconi; Prema M Rao; Srinivasan Rajalakshmi; Fabrizio Sanna; Paolo Pani; A Monni; Dittakavi S R Sarma
Transient inhibition by orotic acid does not abolish the in vivo response of rat hepatocytes to a direct mitogen, lead nitrate.
Journal of hepatology 1997;26(1):203-8.
1995: F S Moreno; M R Rossiello; S Manjeshwar; R Nath; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Effect of beta-carotene on the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat liver.
Cancer letters 1995;96(2):201-8.
1995: S Vasudevan; Ijaz Qureshi; M Lambert; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Nucleotide pool imbalances in the livers of patients with urea cycle disorders associated with increased levels of orotic aciduria.
Biochemistry and molecular biology international 1995;35(3):685-90.
1995: Rosa M Pascale; Maria M Simile; Maria R De Miglio; A Nufris; Lucia Daino; Maria A Seddaiu; P M Rao; Srinivasan Rajalakshmi; D S Sarma; Francesco Feo
Chemoprevention by S-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid.
Carcinogenesis 1995;16(2):427-30.
1994: S Vasudevan; Ezio Laconi; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Perturbations of endogenous levels of orotic acid and carcinogenesis: effect of an arginine-deficient diet and carbamyl aspartate on hepatocarcinogenesis in the rat and the mouse.
Carcinogenesis 1994;15(11):2497-500.
1994: S Manjeshwar; Ezio Laconi; A Sheikh; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
In vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.
Carcinogenesis 1994;15(9):1963-8.
1994: M R Rossiello; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Similar patterns of hypomethylation in the beta-hydroxy-beta-methylglutaryl coenzyme A reductase gene in hepatic nodules induced by different carcinogens.
Molecular carcinogenesis 1994;10(4):237-45.
1994: A Denda; Ezio Laconi; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Sequential histopathological analysis of hepatocarcinogenesis in rats during promotion with orotic acid.
Cancer letters 1994;82(1):55-64.
1994: Ezio Laconi; S Vasudevan; Prema M Rao; Srinivasan Rajalakshmi; P Pani; Dittakavi S R Sarma
An earlier proliferative response of hepatocytes in gamma-glutamyl transferase positive foci to partial hepatectomy.
Cancer letters 1994;81(2):229-35.
1994: K L Backway; Ezio Laconi; S Manjeshwar; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Resistance of hepatic nodules to orotic acid-induced accumulation of uridine nucleotides.
Carcinogenesis 1994;15(2):403-6.
1993: Ezio Laconi; S Vasudevan; Prema M Rao; Srinivasan Rajalakshmi; P Pani; Dittakavi S R Sarma
The development of hepatocellular carcinoma in initiated rat liver after a brief exposure to orotic acid coupled with partial hepatectomy.
Carcinogenesis 1993;14(12):2527-30.
1993: S Manjeshwar; G Pichiri-Coni; P Coni; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Ribonucleotide reductase: a possible target for orotic acid induced mitoinhibition in normal hepatocytes in primary culture.
Cancer letters 1993;73(2-3):149-54.
1993: Ezio Laconi; A Denda; Prema M Rao; Srinivasan Rajalakshmi; P Pani; Dittakavi S R Sarma
Studies on liver tumor promotion in the rat by orotic acid: dose and minimum exposure time required for dietary orotic acid to promote hepatocarcinogenesis.
Carcinogenesis 1993;14(9):1771-5.
1993: Ezio Laconi; S Vasudevan; Prema M Rao; Srinivasan Rajalakshmi; P Pani; Dittakavi S R Sarma
The effect of long-term feeding of orotic acid on the incidence of foci of enzyme-altered hepatocytes and hepatic nodules in Fischer 344 rats.
Carcinogenesis 1993;14(9):1901-5.
1993: Ezio Laconi; S Vasudevan; Prema M Rao; Srinivasan Rajalakshmi; P Pani; Dittakavi S R Sarma
Increasing the interval between initiation and the onset of exposure to orotic acid decreases its promoting effect on rat liver carcinogenesis.
Carcinogenesis 1993;14(8):1701-4.
1993: M R Rossiello; Ezio Laconi; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Induction of hepatic nodules in the rat by aristolochic acid.
Cancer letters 1993;71(1-3):83-7.
1993: R K Sharma; Rosa M Pascale; S Narasimhan; Srinivasan Rajalakshmi
Effect of orotic acid on beta 1,4-galactosyltransferase during liver regeneration.
Carcinogenesis 1993;14(6):1095-9.
1993: A Sheikh; Aroon Yusuf; Ezio Laconi; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Effect of orotic acid on in vivo DNA synthesis in hepatocytes of normal rat liver and in hepatic foci/nodules.
Carcinogenesis 1993;14(5):907-12.
1993: S Manjeshwar; Ezio Laconi; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Influence of orotic acid on multistage hepatocarcinogenesis in the rat: resistance of hepatocytes from nodules to the mitoinhibitory effects of orotic acid.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;202(1):25-9.
1992: S Manjeshwar; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Inhibition of DNA synthesis by phenobarbital in primary cultures of hepatocytes from normal rat liver and from hepatic nodules.
Carcinogenesis 1992;13(12):2287-91.
1992: S Vasudevan; Ijaz Qureshi; L Mores; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Abnormal hepatic nucleotide pools in sparse fur (spf) mutant mice deficient in ornithine transcarbamylase.
Biochemical medicine and metabolic biology 1992;47(3):274-8.
1992: S Manjeshwar; A Sheikh; G Pichiri-Coni; P Coni; Prema M Rao; Srinivasan Rajalakshmi; P Pediaditakis; G Michalopoulos; Dittakavi S R Sarma
Orotic acid, nucleotide-pool imbalance, and liver-tumor promotion: a possible mechanism for the mitoinhibitory effects of orotic acid in isolated rat hepatocytes.
Cancer research 1992;52(7 Suppl):2078s-2081s.
1992: P Coni; J Pang; G Pichiri-Coni; S Hsu; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Hypomethylation of beta-hydroxy-beta-methyl-glutaryl coenzyme A reductase gene and its expression during hepatocarcinogenesis in the rat.
Carcinogenesis 1992;13(3):497-9.
1992: P Coni; G Pichiri-Coni; Giovanna M Ledda-Columbano; E Semple; Srinivasan Rajalakshmi; Prema M Rao; Dittakavi S R Sarma; amedeo columbano
Stimulation of DNA synthesis by rat plasma following in vivo treatment with three liver mitogens.
Cancer letters 1992;61(3):233-8.
1991: Ezio Laconi; Prema M Rao; Srinivasan Rajalakshmi; Paolo Pani; Dittakavi S R Sarma
Chronic mitoinhibition during promotion of hepatocarcinogenesis.
Digestive diseases and sciences 1991;36(9):1294-8.
1990: G Pichiri-Coni; P Coni; Ezio Laconi; P E Schwarze; Per O Seglen; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Studies on the mitoinhibitory effect of orotic acid on hepatocytes in primary culture.
Carcinogenesis 1990;11(6):981-4.
1990: P Coni; G Pichiri-Coni; Giovanna M Ledda-Columbano; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma; amedeo columbano
Liver hyperplasia is not necessarily associated with increased expression of c-fos and c-myc mRNA.
Carcinogenesis 1990;11(5):835-9.
1990: Ezio Laconi; S Vasudevan; C S Rao; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Studies on the effect of dietary orotic acid on mouse liver carcinogenesis induced by diethylnitrosamine.
Cancer letters 1990;49(1):67-71.
1989: P Coni; F A Bignone; G Pichiri; Giovanna M Ledda-Columbano; amedeo columbano; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Studies on the kinetics of expression of cell cycle dependent proto-oncogenes during mitogen-induced liver cell proliferation.
Cancer letters 1989;47(1-2):115-9.
1989: Prema M Rao; A Antony; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Studies on hypomethylation of liver DNA during early stages of chemical carcinogenesis in rat liver.
Carcinogenesis 1989;10(5):933-7.
1989: Rosa M Pascale; S Narasimhan; Srinivasan Rajalakshmi
Expression of N-acetylglucosaminyltransferase III in hepatic nodules generated by different models of rat liver carcinogenesis.
Carcinogenesis 1989;10(5):961-4.
1988: S Vasudevan; G Lee; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Rapid and transient induction of c-fos, c-myc and c-Ha-ras in rat liver following glycine administration.
Biochemical and biophysical research communications 1988;152(1):252-6.
1988: Ezio Laconi; F Li; E Semple; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Inhibition of DNA synthesis in primary cultures of hepatocytes by orotic acid.
Carcinogenesis 1988;9(4):675-7.
1988: S Narasimhan; Harry Schachter; Srinivasan Rajalakshmi
Expression of N-acetylglucosaminyltransferase III in hepatic nodules during rat liver carcinogenesis promoted by orotic acid.
The Journal of biological chemistry 1988;263(3):1273-81.
1987: amedeo columbano; Giovanna M Ledda-Columbano; G Lee; Srinivasan Rajalakshmi; D S Sarma
Inability of mitogen-induced liver hyperplasia to support the induction of enzyme-altered islands induced by liver carcinogens.
Cancer research 1987;47(21):5557-9.
1987: S Vasudevan; Ezio Laconi; S E Abanobi; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Effect of glycine on the induction of orotic aciduria and urinary bladder tumorigenesis in the rat.
Toxicologic pathology 1987;15(2):194-7.
1987: Ezio Laconi; S Vasudevan; Prema M Rao; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Complementarity between two rat liver tumor promoters.
Toxicologic pathology 1987;15(2):198-201.
1987: Prema M Rao; Ezio Laconi; S Vasudevan; A Denda; S Rajagopal; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Dietary and metabolic manipulations of the carcinogenic process: role of nucleotide pool imbalances in carcinogenesis.
Toxicologic pathology 1987;15(2):190-3.
1984: amedeo columbano; Giovanna M Ledda-Columbano; P M Rao; Srinivasan Rajalakshmi; D S Sarma
Occurrence of cell death (apoptosis) in preneoplastic and neoplastic liver cells. A sequential study.
The American journal of pathology 1984;116(3):441-6.
1984: C Laurier; M Tatematsu; P M Rao; Srinivasan Rajalakshmi; D S Sarma
Promotion by orotic acid of liver carcinogenesis in rats initiated by 1,2-dimethylhydrazine.
Cancer research 1984;44(5):2186-91.
1984: Prema M Rao; Y Nagamine; M W Roomi; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Orotic acid, a new promoter for experimental liver carcinogenesis.
Toxicologic pathology 1984;12(2):173-8.
1983: Prema M Rao; K Nagamine; R K Ho; M W Roomi; C Laurier; Srinivasan Rajalakshmi; Dittakavi S R Sarma
Dietary orotic acid enhances the incidence of gamma-glutamyltransferase positive foci in rat liver induced by chemical carcinogens.
Carcinogenesis 1983;4(12):1541-5.