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Uttam RajBhandary

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Living Beings

Escherichia coli

Physiology

Genes & Molecular Sequences

Amino Acid Sequence

Phenomena

Acylation

Procedures

Molecular Cloning

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Co-Publications
Name
13
Köhrer, Caroline
12
Varshney, Umesh
10
Khorana, Gobind
8
Ramesh, Vaidyanathan
7
Drabkin, Harold
5
Gite, S
4
Reeves, Philip
4
Li, Y
4
Mayer, Christine
3
Söll, Dieter
2
Stortchevoi, Alexei
2
Park, Ho-Jin
2
McCloskey, James
2
Chelikani, Prashen
1
Eilers, Markus

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Publications

TOP 3
Kamoshita Nobuhiko; Nomoto Akio; RajBhandary Uttam L
Translation initiation from the ribosomal A site or the P site, dependent on the conformation of RNA pseudoknot I in dicistrovirus RNAs.
RajBhandary Uttam L; Söll Dieter
Aminoacyl-tRNAs, the bacterial cell envelope, and antibiotics.
Yoo Jae-Ho; RajBhandary Uttam L
Requirements for translation re-initiation in Escherichia coli: roles of initiator tRNA and initiation factors IF2 and IF3.

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All Publications

2009: Kamoshita Nobuhiko; Nomoto Akio; RajBhandary Uttam L
Translation initiation from the ribosomal A site or the P site, dependent on the conformation of RNA pseudoknot I in dicistrovirus RNAs.
Molecular cell 2009;35(2):181-90.
2008: RajBhandary Uttam L; Söll Dieter
Aminoacyl-tRNAs, the bacterial cell envelope, and antibiotics.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5285-6.
2008: Yoo Jae-Ho; RajBhandary Uttam L
Requirements for translation re-initiation in Escherichia coli: roles of initiator tRNA and initiation factors IF2 and IF3.
Molecular microbiology 2008;67(5):1012-26.
2008: Köhrer Caroline; Rajbhandary Uttam L
The many applications of acid urea polyacrylamide gel electrophoresis to studies of tRNAs and aminoacyl-tRNA synthetases.
Methods (San Diego, Calif.) 2008;44(2):129-38.
2008: Köhrer Caroline; Srinivasan Gayathri; Mandal Debabrata; Mallick Bibekanand; Ghosh Zhumur; Chakrabarti Jayprokas; Rajbhandary Uttam L
Identification and characterization of a tRNA decoding the rare AUA codon in Haloarcula marismortui.
RNA (New York, N.Y.) 2008;14(1):117-26.
2008: Ye Shixin; Köhrer Caroline; Huber Thomas; Kazmi Manija; Sachdev Pallavi; Yan Elsa C Y; Bhagat Aditi; RajBhandary Uttam L; Sakmar Thomas P
Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis.
The Journal of biological chemistry 2008;283(3):1525-33.
2007: Köhrer Caroline; RajBhandary Uttam L
An evolved ribosome for genetic code expansion.
Nature biotechnology 2007;25(7):745-6.
2007: Chelikani Prashen; Hornak Viktor; Eilers Markus; Reeves Phillip J; Smith Steven O; RajBhandary Uttam L; Khorana H Gobind
Role of group-conserved residues in the helical core of beta2-adrenergic receptor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(17):7027-32.
2006: Söll Dieter; RajBhandary Uttam L
The genetic code - thawing the 'frozen accident'.
Journal of biosciences 2006;31(4):459-63.
2006: RajBhandary Uttam L; Köhrer Caroline
Early days of tRNA research: discovery, function, purification and sequence analysis.
Journal of biosciences 2006;31(4):439-51.
2006: Chelikani Prashen; Reeves Philip J; Rajbhandary Uttam L; Khorana H Gobind
The synthesis and high-level expression of a beta2-adrenergic receptor gene in a tetracycline-inducible stable mammalian cell line.
Protein science : a publication of the Protein Society 2006;15(6):1433-40.
2006: Yang Xiang-Lei; Otero Francella J; Ewalt Karla L; Liu Jianming; Swairjo Manal A; Köhrer Caroline; RajBhandary Uttam L; Skene Robert J; McRee Duncan E; Schimmel Paul
Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.
The EMBO journal 2006;25(12):2919-29.
2006: Kota Parvathi; Reeves Philip J; Rajbhandary Uttam L; Khorana H Gobind
Opsin is present as dimers in COS1 cells: identification of amino acids at the dimeric interface.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3054-9.
2006: Srinivasan Gayathri; Krebs Mark P; RajBhandary Uttam L
Translation initiation with GUC codon in the archaeon Halobacterium salinarum: implications for translation of leaderless mRNA and strict correlation between translation initiation and presence of mRNA.
Molecular microbiology 2006;59(3):1013-24.
2005: Kim Jong-Myoung; Hwa John; Garriga Pere; Reeves Philip J; RajBhandary Uttam L; Khorana H Gobind
Light-driven activation of beta 2-adrenergic receptor signaling by a chimeric rhodopsin containing the beta 2-adrenergic receptor cytoplasmic loops.
Biochemistry 2005;44(7):2284-92.
2004: Köhrer Caroline; Sullivan Eric L; RajBhandary Uttam L
Complete set of orthogonal 21st aminoacyl-tRNA synthetase-amber, ochre and opal suppressor tRNA pairs: concomitant suppression of three different termination codons in an mRNA in mammalian cells.
Nucleic acids research 2004;32(21):6200-11.
2004: Varshney U; Ramesh V; Madabushi A; Gaur R; Subramanya H S; RajBhandary U L
Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase.
Nucleic acids research 2004;32(3):1018-27.
2003: Köhrer Caroline; Yoo Jae-Ho; Bennett Michael; Schaack Jerome; RajBhandary Uttam L
A possible approach to site-specific insertion of two different unnatural amino acids into proteins in mammalian cells via nonsense suppression.
Chemistry & biology 2003;10(11):1095-102.
2003: Mayer Christine; Köhrer Caroline; Kenny Eimear; Prusko Carsten; RajBhandary Uttam L
Anticodon sequence mutants of Escherichia coli initiator tRNA: effects of overproduction of aminoacyl-tRNA synthetases, methionyl-tRNA formyltransferase, and initiation factor 2 on activity in initiation.
Biochemistry 2003;42(17):4787-99.
2003: Stortchevoi Alexei; Varshney Umesh; RajBhandary Uttam L
Common location of determinants in initiator transfer RNAs for initiator-elongator discrimination in bacteria and in eukaryotes.
The Journal of biological chemistry 2003;278(20):17672-9.
2002: Ambrogelly Alexandre; Ahel Ivan; Polycarpo Carla; Bunjun-Srihari Shipra; Krett Bethany; Jacquin-Becker Clarisse; Ruan Benfang; Köhrer Caroline; Stathopoulos Constantinos; RajBhandary Uttam L; Söll Dieter
Methanocaldococcus jannaschii prolyl-tRNA synthetase charges tRNA(Pro) with cysteine.
The Journal of biological chemistry 2002;277(38):34749-54.
2002: Ramesh Vaidyanathan; Köhrer Caroline; RajBhandary Uttam L
Expression of Escherichia coli methionyl-tRNA formyltransferase in Saccharomyces cerevisiae leads to formylation of the cytoplasmic initiator tRNA and possibly to initiation of protein synthesis with formylmethionine.
Molecular and cellular biology 2002;22(15):5434-42.
2002: Mayer Christine; RajBhandary Uttam L
Conformational change of Escherichia coli initiator methionyl-tRNA(fMet) upon binding to methionyl-tRNA formyl transferase.
Nucleic acids research 2002;30(13):2844-50.
2001: Köhrer C; Xie L; Kellerer S; Varshney U; RajBhandary U L
Import of amber and ochre suppressor tRNAs into mammalian cells: a general approach to site-specific insertion of amino acid analogues into proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14310-5.
2001: Kowal A K; Kohrer C; RajBhandary U L
Twenty-first aminoacyl-tRNA synthetase-suppressor tRNA pairs for possible use in site-specific incorporation of amino acid analogues into proteins in eukaryotes and in eubacteria.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2268-73.
2001: Ramesh V; RajBhandary U L
Importance of the anticodon sequence in the aminoacylation of tRNAs by methionyl-tRNA synthetase and by valyl-tRNA synthetase in an Archaebacterium.
The Journal of biological chemistry 2001;276(5):3660-5.
2001: Mayer C; Stortchevoi A; Köhrer C; Varshney U; RajBhandary U L
Initiator tRNA and its role in initiation of protein synthesis.
Cold Spring Harbor symposia on quantitative biology 2001;66():195-206.
2000: Li Y; Ramesh V; Mangroo D; Taneja C; RajBhandary U L
Suppressor mutations in Escherichia coli methionyl-tRNA formyltransferase that compensate for the formylation defect of a mutant tRNA aminoacylated with lysine.
Biochemistry 2000;39(27):8039-46.
2000: Li Y; Holmes W B; Appling D R; RajBhandary U L
Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA.
Journal of bacteriology 2000;182(10):2886-92.
2000: Gite S; Li Y; Ramesh V; RajBhandary U L
Escherichia coli methionyl-tRNA formyltransferase: role of amino acids conserved in the linker region and in the C-terminal domain on the specific recognition of the initiator tRNA.
Biochemistry 2000;39(9):2218-26.
2000: RajBhandary U L
More surprises in translation: initiation without the initiator tRNA.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1325-7.
1999: Ramesh V; Mayer C; Dyson M R; Gite S; RajBhandary U L
Induced fit of a peptide loop of methionyl-tRNA formyltransferase triggered by the initiator tRNA substrate.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):875-80.
1998: Ramesh V; Gite S; RajBhandary U L
Functional interaction of an arginine conserved in the sixteen amino acid insertion module of Escherichia coli methionyl-tRNA formyltransferase with determinants for formylation in the initiator tRNA.
Biochemistry 1998;37(45):15925-32.
1998: Drabkin H J; RajBhandary U L
Initiation of protein synthesis in mammalian cells with codons other than AUG and amino acids other than methionine.
Molecular and cellular biology 1998;18(9):5140-7.
1998: Park H J; RajBhandary U L
Tetracycline-regulated suppression of amber codons in mammalian cells.
Molecular and cellular biology 1998;18(8):4418-25.
1998: Drabkin H J; Estrella M; Rajbhandary U L
Initiator-elongator discrimination in vertebrate tRNAs for protein synthesis.
Molecular and cellular biology 1998;18(3):1459-66.
1997: Ramesh V; Gite S; Li Y; RajBhandary U L
Suppressor mutations in Escherichia coli methionyl-tRNA formyltransferase: role of a 16-amino acid insertion module in initiator tRNA recognition.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13524-9.
1997: Ramesh V; Varshney U; Rajbhandary U L
Intragenic suppression in tRNA: evidence for crosstalk between the D and the T stems.
RNA (New York, N.Y.) 1997;3(11):1220-32.
1997: RajBhandary U L
Once there were twenty.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11761-3.
1997: Gite S; RajBhandary U L
Lysine 207 as the site of cross-linking between the 3'-end of Escherichia coli initiator tRNA and methionyl-tRNA formyltransferase.
The Journal of biological chemistry 1997;272(8):5305-12.
1997: Wu X Q; RajBhandary U L
Effect of the amino acid attached to Escherichia coli initiator tRNA on its affinity for the initiation factor IF2 and on the IF2 dependence of its binding to the ribosome.
The Journal of biological chemistry 1997;272(3):1891-5.
1996: Wu X Q; Iyengar P; RajBhandary U L
Ribosome-initiator tRNA complex as an intermediate in translation initiation in Escherichia coli revealed by use of mutant initiator tRNAs and specialized ribosomes.
The EMBO journal 1996;15(17):4734-9.
1996: Farruggio D; Chaudhuri J; Maitra U; RajBhandary U L
The A1 x U72 base pair conserved in eukaryotic initiator tRNAs is important specifically for binding to the eukaryotic translation initiation factor eIF2.
Molecular and cellular biology 1996;16(8):4248-56.
1996: Mandal N; Mangroo D; Dalluge J J; McCloskey J A; Rajbhandary U L
Role of the three consecutive G:C base pairs conserved in the anticodon stem of initiator tRNAs in initiation of protein synthesis in Escherichia coli.
RNA (New York, N.Y.) 1996;2(5):473-82.
1996: Drabkin H J; Park H J; RajBhandary U L
Amber suppression in mammalian cells dependent upon expression of an Escherichia coli aminoacyl-tRNA synthetase gene.
Molecular and cellular biology 1996;16(3):907-13.
1996: Li S; Kumar N V; Varshney U; RajBhandary U L
Important role of the amino acid attached to tRNA in formylation and in initiation of protein synthesis in Escherichia coli.
The Journal of biological chemistry 1996;271(2):1022-8.
1995: Mangroo D; Wu X Q; RajBhandary U L
Escherichia coli initiator tRNA: structure-function relationships and interactions with the translational machinery.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(11-12):1023-31.
1995: Chow C M; Kang S; Metzenberg R L; RajBhandary U L
Sequence of the met-10+ locus of Neurospora crassa: homology to a sequence of unknown function in Saccharomyces cerevisiae chromosome 8.
Gene 1995;162(1):111-5.
1995: Mangroo D; Limbach P A; McCloskey J A; RajBhandary U L
An anticodon sequence mutant of Escherichia coli initiator tRNA: possible importance of a newly acquired base modification next to the anticodon on its activity in initiation.
Journal of bacteriology 1995;177(10):2858-62.
1995: Mangroo D; RajBhandary U L
Mutants of Escherichia coli initiator tRNA defective in initiation. Effects of overproduction of methionyl-tRNA transformylase and the initiation factors IF2 and IF3.
The Journal of biological chemistry 1995;270(20):12203-9.
1994: Puglisi E V; Puglisi J D; Williamson J R; RajBhandary U L
NMR analysis of tRNA acceptor stem microhelices: discriminator base change affects tRNA conformation at the 3' end.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11467-71.
1994: RajBhandary U L
Initiator transfer RNAs.
Journal of bacteriology 1994;176(3):547-52.
1993: Drabkin H J; Helk B; RajBhandary U L
The role of nucleotides conserved in eukaryotic initiator methionine tRNAs in initiation of protein synthesis.
The Journal of biological chemistry 1993;268(33):25221-8.
1993: Lee C P; Mandal N; Dyson M R; RajBhandary U L
The discriminator base influences tRNA structure at the end of the acceptor stem and possibly its interaction with proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):7149-52.
1993: Chow C M; RajBhandary U L
Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis.
The Journal of biological chemistry 1993;268(17):12855-63.
1993: Chow C M; RajBhandary U L
Developmental regulation of the gene for formate dehydrogenase in Neurospora crassa.
Journal of bacteriology 1993;175(12):3703-9.
1993: Varshney U; Lee C P; RajBhandary U L
From elongator tRNA to initiator tRNA.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2305-9.
1993: Dyson M R; Mandal N; RajBhandary U L
Relationship between the structure and function of Escherichia coli initiator tRNA.
Biochimie 1993;75(12):1051-60.
1992: Mandal N; RajBhandary U L
Escherichia coli B lacks one of the two initiator tRNA species present in E. coli K-12.
Journal of bacteriology 1992;174(23):7827-30.
1992: Varshney U; RajBhandary U L
Role of methionine and formylation of initiator tRNA in initiation of protein synthesis in Escherichia coli.
Journal of bacteriology 1992;174(23):7819-26.
1992: Lee C P; Dyson M R; Mandal N; Varshney U; Bahramian B; RajBhandary U L
Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9262-6.
1991: Lee C P; RajBhandary U L
Mutants of Escherichia coli initiator tRNA that suppress amber codons in Saccharomyces cerevisiae and are aminoacylated with tyrosine by yeast extracts.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11378-82.
1991: Varshney U; Lee C P; RajBhandary U L
Direct analysis of aminoacylation levels of tRNAs in vivo. Application to studying recognition of Escherichia coli initiator tRNA mutants by glutaminyl-tRNA synthetase.
The Journal of biological chemistry 1991;266(36):24712-8.
1991: Varshney U; Lee C P; Seong B L; RajBhandary U L
Mutants of initiator tRNA that function both as initiators and elongators.
The Journal of biological chemistry 1991;266(27):18018-24.
1991: Lee C P; Seong B L; RajBhandary U L
Structural and sequence elements important for recognition of Escherichia coli formylmethionine tRNA by methionyl-tRNA transformylase are clustered in the acceptor stem.
The Journal of biological chemistry 1991;266(27):18012-7.
1991: Krebs M P; Hauss T; Heyn M P; RajBhandary U L; Khorana H G
Expression of the bacterioopsin gene in Halobacterium halobium using a multicopy plasmid.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):859-63.
1990: Krebs M P; RajBhandary U L; Khorana H G
Nucleotide sequence of ISH11, a new Halobacterium halobium insertion element isolated from the plasmid pGRB1.
Nucleic acids research 1990;18(22):6699.
1990: Francis M A; Rajbhandary U L
Expression and function of a human initiator tRNA gene in the yeast Saccharomyces cerevisiae.
Molecular and cellular biology 1990;10(9):4486-94.
1990: Hackett N R; Krebs M P; DasSarma S; Goebel W; RajBhandary U L; Khorana H G
Nucleotide sequence of a high copy number plasmid from Halobacterium strain GRB.
Nucleic acids research 1990;18(11):3408.
1990: Varshney U; RajBhandary U L
Initiation of protein synthesis from a termination codon.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1586-90.
1989: Chow C M; Metzenberg R L; Rajbhandary U L
Nuclear gene for mitochondrial leucyl-tRNA synthetase of Neurospora crassa: isolation, sequence, chromosomal mapping, and evidence that the leu-5 locus specifies structural information.
Molecular and cellular biology 1989;9(11):4631-44.
1989: Chow C M; Rajbhandary U L
Regulation of the nuclear genes encoding the cytoplasmic and mitochondrial leucyl-tRNA synthetases of Neurospora crassa.
Molecular and cellular biology 1989;9(11):4645-52.
1989: Seong B L; Lee C P; RajBhandary U L
Suppression of amber codons in vivo as evidence that mutants derived from Escherichia coli initiator tRNA can act at the step of elongation in protein synthesis.
The Journal of biological chemistry 1989;264(11):6504-8.
1989: Sachs M S; Bertrand H; Metzenberg R L; RajBhandary U L
Cytochrome oxidase subunit V gene of Neurospora crassa: DNA sequences, chromosomal mapping, and evidence that the cya-4 locus specifies the structural gene for subunit V.
Molecular and cellular biology 1989;9(2):566-77.
1988: Benarous R; Chow C M; RajBhandary U L
Cytoplasmic leucyl-tRNA synthetase of Neurospora crassa is not specified by the leu-5 locus.
Genetics 1988;119(4):805-14.
1988: Ganguly S; Sharp P A; RajBhandary U L
Saccharomyces cerevisiae SUP53 tRNA gene transcripts are processed by mammalian cell extracts in vitro but are not processed in vivo.
Molecular and cellular biology 1988;8(1):361-70.
1987: Seong B L; RajBhandary U L
Mutants of Escherichia coli formylmethionine tRNA: a single base change enables initiator tRNA to act as an elongator in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8859-63.
1987: Seong B L; RajBhandary U L
Escherichia coli formylmethionine tRNA: mutations in GGGCCC sequence conserved in anticodon stem of initiator tRNAs affect initiation of protein synthesis and conformation of anticodon loop.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(2):334-8.
1985: Drabkin H J; RajBhandary U L
Attempted expression of a human initiator tRNA gene in Saccharomyces cerevisiae.
The Journal of biological chemistry 1985;260(9):5596-602.
1985: Drabkin H J; RajBhandary U L
Expression in vivo of a mutant human initiator tRNA gene in mammalian cells using a simian virus 40 vector.
The Journal of biological chemistry 1985;260(9):5588-95.
1985: Drabkin H J; RajBhandary U L
Site-specific mutagenesis on a human initiator methionine tRNA gene within a sequence conserved in all eukaryotic initiator tRNAs and studies of its effects on in vitro transcription.
The Journal of biological chemistry 1985;260(9):5580-7.
1983: DasSarma S; RajBhandary U L; Khorana H G
High-frequency spontaneous mutation in the bacterio-opsin gene in Halobacterium halobium is mediated by transposable elements.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(8):2201-5.
1982: Simsek M; DasSarma S; RajBhandary U L; Khorana H G
A transposable element from Halobacterium halobium which inactivates the bacteriorhodopsin gene.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(23):7268-72.
1982: Ghosh H P; Ghosh K; Simsek M; RajBhandary U L
Nucleotide sequence of wheat germ cytoplasmic initiator methionine transfer ribonucleic acid.
Nucleic acids research 1982;10(10):3241-7.
1981: Dunn R; McCoy J; Simsek M; Majumdar A; Chang S H; Rajbhandary U L; Khorana H G
The bacteriorhodopsin gene.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(11):6744-8.

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