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Konrad Beyreuther

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Disorders

Alzheimer Disease

Genes & Molecular Sequences

Amino Acid Sequence

Concepts & Ideas

Molecular Sequence Data

Anatomy

Living Beings

Mice
Rats

Procedures

Immunohistochemistry

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Co-Publications
Name
223
Masters, Colin
71
Multhaup, Gerd
47
Cappai, Roberto
29
Small, David
24
Bush, Ashley
22
Weidemann, Andreas
21
Evin, Geneviève
21
Li, Qiao-Xin
18
Bayer, Thomas
16
Culvenor, Janetta
16
White, Anthony
15
McLean, Catriona
14
Hartmann, Tobias
11
Galatis, Denise
11
Ida, N

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Publications

TOP 3
Lv J; Jia H; Jiang Y; Ruan Y; Liu Z; Yue W; Beyreuther K; Tu P; Zhang D
Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro.
Radzimanowski Jens; Simon Bernd; Sattler Michael; Beyreuther Konrad; Sinning Irmgard; Wild Klemens
Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Radzimanowski Jens; Ravaud Stéphanie; Schlesinger Sabine; Koch Joachim; Beyreuther Konrad; Sinning Irmgard; Wild Klemens
Crystal structure of the human Fe65-PTB1 domain.

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All Publications

2009: Lv J; Jia H; Jiang Y; Ruan Y; Liu Z; Yue W; Beyreuther K; Tu P; Zhang D
Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro.
Acta physiologica (Oxford, England) 2009;196(4):419-25.
2008: Radzimanowski Jens; Simon Bernd; Sattler Michael; Beyreuther Konrad; Sinning Irmgard; Wild Klemens
Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
EMBO reports 2008;9(11):1134-40.
2008: Radzimanowski Jens; Ravaud Stéphanie; Schlesinger Sabine; Koch Joachim; Beyreuther Konrad; Sinning Irmgard; Wild Klemens
Crystal structure of the human Fe65-PTB1 domain.
The Journal of biological chemistry 2008;283(34):23113-20.
2008: Wun Kwok S; Miles Luke A; Crespi Gabriela A N; Wycherley Kaye; Ascher David B; Barnham Kevin J; Cappai Roberto; Beyreuther Konrad; Masters Colin L; Parker Michael W; McKinstry William J
Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 5):438-41.
2008: Radzimanowski Jens; Beyreuther Konrad; Sinning Irmgard; Wild Klemens
Overproduction, purification, crystallization and preliminary X-ray analysis of human Fe65-PTB2 in complex with the amyloid precursor protein intracellular domain.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 5):409-12.
2008: Radzimanowski Jens; Ravaud Stéphanie; Beyreuther Konrad; Sinning Irmgard; Wild Klemens
Mercury-induced crystallization and SAD phasing of the human Fe65-PTB1 domain.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 5):382-5.
2008: Grimm Marcus O W; Grimm Heike S; Tomic Inge; Beyreuther Konrad; Hartmann Tobias; Bergmann Christine
Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels.
The Journal of biological chemistry 2008;283(17):11302-11.
2008: Miles Luke A; Wun Kwok S; Crespi Gabriela A N; Fodero-Tavoletti Michelle T; Galatis Denise; Bagley Christopher J; Beyreuther Konrad; Masters Colin L; Cappai Roberto; McKinstry William J; Barnham Kevin J; Parker Michael W
Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.
Journal of molecular biology 2008;377(1):181-92.
2007: Back Simone; Haas Petra; Tschäpe Jakob-A; Gruebl Tomas; Kirsch Joachim; Müller Ulrike; Beyreuther Konrad; Kins Stefan
beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment.
Journal of neuroscience research 2007;85(12):2580-90.
2007: Beyreuther K; Biesalski H K; Fernstrom J D; Grimm P; Hammes W P; Heinemann U; Kempski O; Stehle P; Steinhart H; Walker R
Consensus meeting: monosodium glutamate - an update.
European journal of clinical nutrition 2007;61(3):304-13.
2007: Rusu Patricia; Jansen Anna; Soba Peter; Kirsch Joachim; Löwer Alexander; Merdes Gunter; Kuan Yung-Hui; Jung Anita; Beyreuther Konrad; Kjaerulff Ole; Kins Stefan
Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity.
The European journal of neuroscience 2007;25(4):1079-86.
2006: Kuan Yung-Hui; Gruebl Tomas; Soba Peter; Eggert Simone; Nesic Iva; Back Simone; Kirsch Joachim; Beyreuther Konrad; Kins Stefan
PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.
The Journal of biological chemistry 2006;281(52):40114-23.
2006: Masters Colin L; Beyreuther Konrad
Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway.
Brain : a journal of neurology 2006;129(Pt 11):2823-39.
2006: Liu Zhonghua; Ruan Yanyan; Yue Weihua; Zhu Zhihui; Hartmann Tobias; Beyreuther Konrad; Zhang Dai
GM1 up-regulates Ubiquilin 1 expression in human neuroblastoma cells and rat cortical neurons.
Neuroscience letters 2006;407(1):59-63.
2006: Barnham Kevin J; Cappai Roberto; Beyreuther Konrad; Masters Colin L; Hill Andrew F
Delineating common molecular mechanisms in Alzheimer's and prion diseases.
Trends in biochemical sciences 2006;31(8):465-72.
2006: Kins Stefan; Beyreuther Konrad
Teasing out the tangles.
Nature medicine 2006;12(7):764-5; discussion 765.
2006: Kwak Y-D; Brannen C L; Qu T; Kim H M; Dong X; Soba P; Majumdar A; Kaplan A; Beyreuther K; Sugaya K
Amyloid precursor protein regulates differentiation of human neural stem cells.
Stem cells and development 2006;15(3):381-9.
2006: Kins Stefan; Lauther Nadine; Szodorai Anita; Beyreuther Konrad
Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease.
Neuro-degenerative diseases 2006;3(4-5):218-26.
2006: Masters Colin L; Beyreuther Konrad
Pathways to the discovery of the Abeta amyloid of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):155-61.
2005: Yavich Leonid; Oksman Mari; Tanila Heikki; Kerokoski Petri; Hiltunen Mikko; van Groen Thomas; Puoliväli Jukka; Männistö Pekka T; García-Horsman Arturo; MacDonald Ewen; Beyreuther Konrad; Hartmann Tobias; Jäkälä Pekka
Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.
Neurobiology of disease 2005;20(2):303-13.
2005: Soba Peter; Eggert Simone; Wagner Katja; Zentgraf Hanswalter; Siehl Katjuscha; Kreger Sylvia; Löwer Alexander; Langer Andreas; Merdes Gunter; Paro Renato; Masters Colin L; Müller Ulrike; Kins Stefan; Beyreuther Konrad
Homo- and heterodimerization of APP family members promotes intercellular adhesion.
The EMBO journal 2005;24(20):3624-34.
2004: Merdes Gunter; Soba Peter; Loewer Alexander; Bilic Michaela V; Beyreuther Konrad; Paro Renato
Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila.
The EMBO journal 2004;23(20):4082-95.
2004: Zha Q; Ruan Y; Hartmann T; Beyreuther K; Zhang D
GM1 ganglioside regulates the proteolysis of amyloid precursor protein.
Molecular psychiatry 2004;9(10):946-52.
2004: Barnham Kevin J; Haeffner Fredrik; Ciccotosto Giuseppe D; Curtain Cyril C; Tew Deborah; Mavros Christine; Beyreuther Konrad; Carrington Darryl; Masters Colin L; Cherny Robert A; Cappai Roberto; Bush Ashley I
Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1427-9.
2004: Jia Hongxiao; Jiang Yong; Ruan Yan; Zhang Yanbo; Ma Xin; Zhang Jizhi; Beyreuther Konrad; Tu Penfei; Zhang Dai
Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells.
Neuroscience letters 2004;367(1):123-8.
2004: George Amee J; Holsinger R M Damian; McLean Catriona A; Laughton Katrina M; Beyreuther Konrad; Evin Genevieve; Masters Colin L; Li Qiao-Xin
APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease.
Neurobiology of disease 2004;16(1):124-32.
2004: Loewer Alexander; Soba Peter; Beyreuther Konrad; Paro Renato; Merdes Gunter
Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.
EMBO reports 2004;5(4):405-11.
2004: Eggert Simone; Paliga Krzysztof; Soba Peter; Evin Genevieve; Masters Colin L; Weidemann Andreas; Beyreuther Konrad
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation.
The Journal of biological chemistry 2004;279(18):18146-56.
2004: White Anthony R; Barnham Kevin J; Huang Xudong; Voltakis Irene; Beyreuther Konrad; Masters Colin L; Cherny Robert A; Bush Ashley I; Cappai Roberto
Iron inhibits neurotoxicity induced by trace copper and biological reductants.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(3):269-80.
2004: Fassbender K; Walter S; Kühl S; Landmann R; Ishii K; Bertsch T; Stalder A K; Muehlhauser F; Liu Y; Ulmer A J; Rivest S; Lentschat A; Gulbins E; Jucker M; Staufenbiel M; Brechtel K; Walter J; Multhaup G; Penke B; Adachi Y; Hartmann T; Beyreuther K
The LPS receptor (CD14) links innate immunity with Alzheimer's disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):203-5.
2003: Ritchie Craig W; Bush Ashley I; Mackinnon Andrew; Macfarlane Steve; Mastwyk Maree; MacGregor Lachlan; Kiers Lyn; Cherny Robert; Li Qiao-Xin; Tammer Amanda; Carrington Darryl; Mavros Christine; Volitakis Irene; Xilinas Michel; Ames David; Davis Stephen; Beyreuther Konrad; Tanzi Rudolph E; Masters Colin L
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.
Archives of neurology 2003;60(12):1685-91.
2003: Schmechel Ariane; Zentgraf Hanswalter; Scheuermann Stefan; Fritz Guenter; Pipkorn Rüdiger; Reed Jennifer; Beyreuther Konrad; Bayer Thomas A; Multhaup Gerd
Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies.
The Journal of biological chemistry 2003;278(37):35317-24.
2003: Barnham Kevin J; McKinstry William J; Multhaup Gerd; Galatis Denise; Morton Craig J; Curtain Cyril C; Williamson Nicholas A; White Anthony R; Hinds Mark G; Norton Raymond S; Beyreuther Konrad; Masters Colin L; Parker Michael W; Cappai Roberto
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
The Journal of biological chemistry 2003;278(19):17401-7.
2003: Grimm Heike S; Beher Dirk; Lichtenthaler Stefan F; Shearman Mark S; Beyreuther Konrad; Hartmann Tobias
gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.
The Journal of biological chemistry 2003;278(15):13077-85.
2003: Rutten Bart P F; Wirths Oliver; Van de Berg Wilma D J; Lichtenthaler Stefan F; Vehoff Jochen; Steinbusch Harry W M; Korr Hubert; Beyreuther Konrad; Multhaup Gerd; Bayer Thomas A; Schmitz Christoph
No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment.
Neurobiology of disease 2003;12(2):110-20.
2003: White Anthony R; Maher Fran; Brazier Marcus W; Jobling Michael F; Thyer James; Stewart Leanne R; Thompson Andrew; Gibson Riki; Masters Colin L; Multhaup Gerd; Beyreuther Konrad; Barrow Colin J; Collins Steven J; Cappai Roberto
Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation.
Brain research 2003;966(2):231-44.
2003: Sernee M Fleur; Evin Geneviève; Culvenor Janetta G; Villadangos José A; Beyreuther Konrad; Masters Colin L; Cappai Roberto
Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage.
European journal of biochemistry / FEBS 2003;270(3):495-506.
2003: Grziwa Beate; Grimm Marcus O W; Masters Colin L; Beyreuther Konrad; Hartmann Tobias; Lichtenthaler Stefan F
The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted.
The Journal of biological chemistry 2003;278(9):6803-8.
2003: Gamliel A; Teicher C; Hartmann T; Beyreuther K; Stein R
Overexpression of wild-type presenilin 2 or its familial Alzheimer's disease-associated mutant does not induce or increase susceptibility to apoptosis in different cell lines.
Neuroscience 2003;117(1):19-28.
2002: Khalil Zeinab; Poliviou Helen; Maynard Christa J; Beyreuther Konrad; Masters Colin L; Li Qiao-Xin
Mechanisms of peripheral microvascular dysfunction in transgenic mice overexpressing the Alzheimer's disease amyloid Abeta protein.
Journal of Alzheimer's disease : JAD 2002;4(6):467-78.
2002: Maynard Christa J; Cappai Roberto; Volitakis Irene; Cherny Robert A; White Anthony R; Beyreuther Konrad; Masters Colin L; Bush Ashley I; Li Qiao-Xin
Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.
The Journal of biological chemistry 2002;277(47):44670-6.
2002: Simons Mikael; Schwärzler Frank; Lütjohann Dieter; von Bergmann Klaus; Beyreuther Konrad; Dichgans Johannes; Wormstall Henning; Hartmann Tobias; Schulz Jörg B
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial.
Annals of neurology 2002;52(3):346-50.
2002: Li Qiao-Xin; Campbell Bruce C V; McLean Catriona A; Thyagarajan Domimic; Gai Wei-Ping; Kapsa Robert M; Beyreuther Konrad; Masters Colin L; Culvenor Janetta G
Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects.
Journal of Alzheimer's disease : JAD 2002;4(4):309-15.
2002: Wirths Oliver; Multhaup Gerd; Czech Christian; Feldmann Nicole; Blanchard Véronique; Tremp Günter; Beyreuther Konrad; Pradier Laurent; Bayer Thomas A
Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.
Brain pathology (Zurich, Switzerland) 2002;12(3):275-86.
2002: Simons Andreas; Ruppert Thomas; Schmidt Carsten; Schlicksupp Andrea; Pipkorn Rüdiger; Reed Jennifer; Masters Colin L; White Anthony R; Cappai Roberto; Beyreuther Konrad; Bayer Thomas A; Multhaup Gerd
Evidence for a copper-binding superfamily of the amyloid precursor protein.
Biochemistry 2002;41(30):9310-20.
2002: Lütjohann Dieter; Brzezinka Andreas; Barth Esther; Abramowski Dorothee; Staufenbiel Matthias; von Bergmann Klaus; Beyreuther Konrad; Multhaup Gerd; Bayer Thomas A
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.
Journal of lipid research 2002;43(7):1078-85.
2002: Holsinger R M Damian; McLean Catriona A; Beyreuther Konrad; Masters Colin L; Evin Geneviève
Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease.
Annals of neurology 2002;51(6):783-6.
2002: Mok Su San; Turner Bradley J; Beyreuther Konrad; Masters Colin L; Barrow Colin J; Small David H
Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine.
European journal of biochemistry / FEBS 2002;269(12):3014-22.
2002: Hamilton John A; Whitty Genevieve; White Anthony R; Jobling Michael F; Thompson Andrew; Barrow Colin J; Cappai Roberto; Beyreuther Konrad; Masters Colin L
Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF).
Brain research 2002;940(1-2):49-54.
2002: Fodero Lisa R; Sáez-Valero Javier; McLean Catriona A; Martins Ralph N; Beyreuther Konrad; Masters Colin L; Robertson Terry A; Small David H
Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition.
Journal of neurochemistry 2002;81(3):441-8.
2002: Evin Geneviève; Smith Margaret J; Tziotis Angela; McLean Catriona; Canterford Louise; Sharples Robyn A; Cappai Roberto; Weidemann Andreas; Beyreuther Konrad; Cotton Richard G H; Masters Colin L; Culvenor Janetta G
Alternative transcripts of presenilin-1 associated with frontotemporal dementia.
Neuroreport 2002;13(6):917-21.
2002: Schönknecht Peter; Lütjohann Dieter; Pantel Johannes; Bardenheuer Habertus; Hartmann Tobias; von Bergmann Klaus; Beyreuther Konrad; Schröder Johannes
Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls.
Neuroscience letters 2002;324(1):83-5.
2002: Evin Geneviève; Smith Margaret J; Tziotis Angela; McLean Catriona; Canterford Louise; Sharples Robyn A; Cappai Roberto; Weidemann Andreas; Beyreuther Konrad; Cotton Richard G H; Masters Colin L; Culvenor Janetta G
Alternative transcripts of presenilin-1 associated with frontotemporal dementia.
Neuroreport 2002;13(5):719-23.
2002: Runz Heiko; Rietdorf Jens; Tomic Inge; de Bernard Marina; Beyreuther Konrad; Pepperkok Rainer; Hartmann Tobias
Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1679-89.
2002: Weidemann Andreas; Eggert Simone; Reinhard Friedrich B M; Vogel Markus; Paliga Krzysztof; Baier Gottfried; Masters Colin L; Beyreuther Konrad; Evin Geneviève
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.
Biochemistry 2002;41(8):2825-35.
2002: Lichtenthaler Stefan F; Beher Dirk; Grimm Heike S; Wang Rong; Shearman Mark S; Masters Colin L; Beyreuther Konrad
The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1365-70.
2002: Gamliel Amir; Teicher Carmit; Michaelson Daniel M; Pradier Laurent; Hartmann Tobias; Beyreuther Konrad; Stein Reuven
Increased expression of presenilin 2 inhibits protein synthesis.
Molecular and cellular neurosciences 2002;19(1):111-24.
2002: White Anthony R; Multhaup Gerd; Galatis Denise; McKinstry William J; Parker Michael W; Pipkorn Rüdiger; Beyreuther Konrad; Masters Colin L; Cappai Roberto
Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(2):365-76.
2001: Wirths O; Multhaup G; Czech C; Blanchard V; Tremp G; Pradier L; Beyreuther K; Bayer T A
Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Neuroscience letters 2001;316(3):145-8.
2001: Nunan J; Shearman M S; Checler F; Cappai R; Evin G; Beyreuther K; Masters C L; Small D H
The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase.
European journal of biochemistry / FEBS 2001;268(20):5329-36.
2001: Stewart L R; White A R; Jobling M F; Needham B E; Maher F; Thyer J; Beyreuther K; Masters C L; Collins S J; Cappai R
Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126.
Journal of neuroscience research 2001;65(6):565-72.
2001: Scheuermann S; Hambsch B; Hesse L; Stumm J; Schmidt C; Beher D; Bayer T A; Beyreuther K; Multhaup G
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.
The Journal of biological chemistry 2001;276(36):33923-9.
2001: Evin G; Sharples R A; Weidemann A; Reinhard F B; Carbone V; Culvenor J G; Holsinger R M; Sernee M F; Beyreuther K; Masters C L
Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.
Biochemistry 2001;40(28):8359-68.
2001: Fassbender K; Masters C; Beyreuther K
Alzheimer's disease: molecular concepts and therapeutic targets.
Die Naturwissenschaften 2001;88(6):261-7.
2001: Cherny R A; Atwood C S; Xilinas M E; Gray D N; Jones W D; McLean C A; Barnham K J; Volitakis I; Fraser F W; Kim Y; Huang X; Goldstein L E; Moir R D; Lim J T; Beyreuther K; Zheng H; Tanzi R E; Masters C L; Bush A I
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Neuron 2001;30(3):665-76.
2001: Wirths O; Multhaup G; Czech C; Blanchard V; Moussaoui S; Tremp G; Pradier L; Beyreuther K; Bayer T A
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Neuroscience letters 2001;306(1-2):116-20.
2001: Curtain C C; Ali F; Volitakis I; Cherny R A; Norton R S; Beyreuther K; Barrow C J; Masters C L; Bush A I; Barnham K J
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits.
The Journal of biological chemistry 2001;276(23):20466-73.
2001: Jayasena U L; Gribble S K; McKenzie A; Beyreuther K; Masters C L; Underwood J R
Identification of structural variations in the carboxyl terminus of Alzheimer's disease-associated beta A4[1-42] amyloid using a monoclonal antibody.
Clinical and experimental immunology 2001;124(2):297-305.
2001: Fassbender K; Simons M; Bergmann C; Stroick M; Lutjohann D; Keller P; Runz H; Kuhl S; Bertsch T; von Bergmann K; Hennerici M; Beyreuther K; Hartmann T
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5856-61.
2001: Masters C L; Beyreuther K
The Worster-Drought syndrome and other syndromes of dementia with spastic paraparesis: the paradox of molecular pathology.
Journal of neuropathology and experimental neurology 2001;60(4):317-9.
2001: White A R; Guirguis R; Brazier M W; Jobling M F; Hill A F; Beyreuther K; Barrow C J; Masters C L; Collins S J; Cappai R
Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons.
Neurobiology of disease 2001;8(2):299-316.
2001: White A R; Huang X; Jobling M F; Barrow C J; Beyreuther K; Masters C L; Bush A I; Cappai R
Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways.
Journal of neurochemistry 2001;76(5):1509-20.
2001: Campbell B C; McLean C A; Culvenor J G; Gai W P; Blumbergs P C; Jäkälä P; Beyreuther K; Masters C L; Li Q X
The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease.
Journal of neurochemistry 2001;76(1):87-96.
2001: Bayer T A; Wirths O; Majtényi K; Hartmann T; Multhaup G; Beyreuther K; Czech C
Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport.
Brain pathology (Zurich, Switzerland) 2001;11(1):1-11.
2000: Wirths O; Weickert S; Majtenyi K; Havas L; Kahle P J; Okochi M; Haass C; Multhaup G; Beyreuther K; Bayer T A
Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques.
Neuroreport 2000;11(17):3737-41.
2000: Schonknecht P; Pantel J; Werle E; Hartmann T; Essig M; Baudendistel K; Beyreuther K; Schroder J
[Cerebrospinal fluid protein tau levels in the differential diagnosis of Alzheimer's disease]
Fortschritte der Neurologie-Psychiatrie 2000;68(10):439-46.
2000: Leloup C; Michaelson D M; Fisher A; Hartmann T; Beyreuther K; Stein R
M1 muscarinic receptors block caspase activation by phosphoinositide 3-kinase- and MAPK/ERK-independent pathways.
Cell death and differentiation 2000;7(9):825-33.
2000: Mok S S; Clippingdale A B; Beyreuther K; Masters C L; Barrow C J; Small D H
A beta peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture.
Journal of neuroscience research 2000;61(4):449-57.
2000: Ishii K; Muelhauser F; Liebl U; Picard M; Kühl S; Penke B; Bayer T; Wiessler M; Hennerici M; Beyreuther K; Hartmann T; Fassbender K
Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: reversal by inhibition of the inducible NO synthase.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(11):1485-9.
2000: Cherny R A; Barnham K J; Lynch T; Volitakis I; Li Q X; McLean C A; Multhaup G; Beyreuther K; Tanzi R E; Masters C L; Bush A I
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
Journal of structural biology 2000;130(2-3):209-16.
2000: Borchardt T; Schmidt C; Camarkis J; Cappai R; Masters C L; Beyreuther K; Multhaup G
Differential effects of zinc on amyloid precursor protein (APP) processing in copper-resistant variants of cultured Chinese hamster ovary cells.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(4):785-95.
2000: Campbell B C; Li Q X; Culvenor J G; Jäkälä P; Cappai R; Beyreuther K; Masters C L; McLean C A
Accumulation of insoluble alpha-synuclein in dementia with Lewy bodies.
Neurobiology of disease 2000;7(3):192-200.
2000: Fassbender K; Masters C; Beyreuther K
Alzheimer's disease: an inflammatory disease?
Neurobiology of aging 2000;21(3):433-6; discussion 451-3.
2000: Jensen M; Hartmann T; Engvall B; Wang R; Uljon S N; Sennvik K; Näslund J; Muehlhauser F; Nordstedt C; Beyreuther K; Lannfelt L
Quantification of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems.
Molecular medicine (Cambridge, Mass.) 2000;6(4):291-302.
2000: Emilien G; Beyreuther K; Masters C L; Maloteaux J M
Prospects for pharmacological intervention in Alzheimer disease.
Archives of neurology 2000;57(4):454-9.
2000: Smith M J; Humphrey K E; Cappai R; Beyreuther K; Masters C L; Cotton R G
Correct heteroduplex formation for mutation detection analysis.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology 2000;5(1):67-73.
2000: Uhrig R K; Picard M A; Beyreuther K; Wiessler M
Synthesis of antioxidative and anti-inflammatory drugs glucoconjugates.
Carbohydrate research 2000;325(1):72-80.
2000: Culvenor J G; Evin G; Cooney M A; Wardan H; Sharples R A; Maher F; Reed G; Diehlmann A; Weidemann A; Beyreuther K; Masters C L
Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells.
Experimental cell research 2000;255(2):192-206.
2000: Postuma R B; He W; Nunan J; Beyreuther K; Masters C L; Barrow C J; Small D H
Substrate-bound beta-amyloid peptides inhibit cell adhesion and neurite outgrowth in primary neuronal cultures.
Journal of neurochemistry 2000;74(3):1122-30.
2000: Coulson E J; Paliga K; Beyreuther K; Masters C L
What the evolution of the amyloid protein precursor supergene family tells us about its function.
Neurochemistry international 2000;36(3):175-84.
2000: Emilien G; Maloteaux J M; Beyreuther K; Masters C L
Alzheimer disease: mouse models pave the way for therapeutic opportunities.
Archives of neurology 2000;57(2):176-81.
2000: Evin G; Le Brocque D; Culvenor J G; Galatis D; Weidemann A; Beyreuther K; Masters C L; Cappai R
Presenilin I expression in yeast lowers secretion of the amyloid precursor protein.
Neuroreport 2000;11(2):405-8.
2000: Kwok J B; Li Q X; Hallupp M; Whyte S; Ames D; Beyreuther K; Masters C L; Schofield P R
Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis.
Annals of neurology 2000;47(2):249-53.
2000: Bergsdorf C; Paliga K; Kreger S; Masters C L; Beyreuther K
Identification of cis-elements regulating exon 15 splicing of the amyloid precursor protein pre-mRNA.
The Journal of biological chemistry 2000;275(3):2046-56.
2000: Masters C L; Beyreuther K
Genomic neurology.
Archives of neurology 2000;57(1):53.
1999: McLean C A; Cherny R A; Fraser F W; Fuller S J; Smith M J; Beyreuther K; Bush A I; Masters C L
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease.
Annals of neurology 1999;46(6):860-6.
1999: Borchardt T; Camakaris J; Cappai R; Masters C L; Beyreuther K; Multhaup G
Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion.
The Biochemical journal 1999;344 Pt 2():461-7.
1999: Caswell M D; Mok S S; Henry A; Cappai R; Klug G; Beyreuther K; Masters C L; Small D H
The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons.
European journal of biochemistry / FEBS 1999;266(2):509-16.
1999: Small D H; Clarris H L; Williamson T G; Reed G; Key B; Mok S S; Beyreuther K; Masters C L; Nurcombe V
Neurite-outgrowth regulating functions of the amyloid protein precursor of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 1999;1(4-5):275-85.
1999: Bayer T A; Cappai R; Masters C L; Beyreuther K; Multhaup G
It all sticks together--the APP-related family of proteins and Alzheimer's disease.
Molecular psychiatry 1999;4(6):524-8.
1999: White A R; Collins S J; Maher F; Jobling M F; Stewart L R; Thyer J M; Beyreuther K; Masters C L; Cappai R
Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity.
The American journal of pathology 1999;155(5):1723-30.
1999: White A R; Multhaup G; Maher F; Bellingham S; Camakaris J; Zheng H; Bush A I; Beyreuther K; Masters C L; Cappai R
The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(21):9170-9.
1999: Li Q X; Fuller S J; Beyreuther K; Masters C L
The amyloid precursor protein of Alzheimer disease in human brain and blood.
Journal of leukocyte biology 1999;66(4):567-74.
1999: Culvenor J G; McLean C A; Cutt S; Campbell B C; Maher F; Jäkälä P; Hartmann T; Beyreuther K; Masters C L; Li Q X
Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.
The American journal of pathology 1999;155(4):1173-81.
1999: Jobling M F; Stewart L R; White A R; McLean C; Friedhuber A; Maher F; Beyreuther K; Masters C L; Barrow C J; Collins S J; Cappai R
The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126.
Journal of neurochemistry 1999;73(4):1557-65.
1999: White A R; Reyes R; Mercer J F; Camakaris J; Zheng H; Bush A I; Multhaup G; Beyreuther K; Masters C L; Cappai R
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice.
Brain research 1999;842(2):439-44.
1999: Bayer T A; Jäkälä P; Hartmann T; Egensperger R; Buslei R; Falkai P; Beyreuther K
Neural expression profile of alpha-synuclein in developing human cortex.
Neuroreport 1999;10(13):2799-803.
1999: Cherny R A; Legg J T; McLean C A; Fairlie D P; Huang X; Atwood C S; Beyreuther K; Tanzi R E; Masters C L; Bush A I
Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.
The Journal of biological chemistry 1999;274(33):23223-8.
1999: Christie G; Markwell R E; Gray C W; Smith L; Godfrey F; Mansfield F; Wadsworth H; King R; McLaughlin M; Cooper D G; Ward R V; Howlett D R; Hartmann T; Lichtenthaler S F; Beyreuther K; Underwood J; Gribble S K; Cappai R; Masters C L; Tamaoka A; Gardner R L; Rivett A J; Karran E H; Allsop D
Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.
Journal of neurochemistry 1999;73(1):195-204.
1999: Masters C L; Beyreuther K
Amyloid Nomenclature Committee.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1999;6(2):151-2.
1999: Lichtenthaler S F; Multhaup G; Masters C L; Beyreuther K
A novel substrate for analyzing Alzheimer's disease gamma-secretase.
FEBS letters 1999;453(3):288-92.
1999: Li Q X; Maynard C; Cappai R; McLean C A; Cherny R A; Lynch T; Culvenor J G; Trevaskis J; Tanner J E; Bailey K A; Czech C; Bush A I; Beyreuther K; Masters C L
Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.
Journal of neurochemistry 1999;72(6):2479-87.
1999: Bayer T A; Jäkälä P; Hartmann T; Havas L; McLean C; Culvenor J G; Li Q X; Masters C L; Falkai P; Beyreuther K
Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.
Neuroscience letters 1999;266(3):213-6.
1999: Diehlmann A; Ida N; Weggen S; Grünberg J; Haass C; Masters C L; Bayer T A; Beyreuther K
Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies.
Journal of neuroscience research 1999;56(4):405-19.
1999: White A R; Bush A I; Beyreuther K; Masters C L; Cappai R
Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione.
Journal of neurochemistry 1999;72(5):2092-8.
1999: Storey E; Katz M; Brickman Y; Beyreuther K; Masters C L
Amyloid precursor protein of Alzheimer's disease: evidence for a stable, full-length, trans-membrane pool in primary neuronal cultures.
The European journal of neuroscience 1999;11(5):1779-88.
1999: Jensen M; Schröder J; Blomberg M; Engvall B; Pantel J; Ida N; Basun H; Wahlund L O; Werle E; Jauss M; Beyreuther K; Lannfelt L; Hartmann T
Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression.
Annals of neurology 1999;45(4):504-11.
1999: Rossjohn J; Cappai R; Feil S C; Henry A; McKinstry W J; Galatis D; Hesse L; Multhaup G; Beyreuther K; Masters C L; Parker M W
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
Nature structural biology 1999;6(4):327-31.
1999: Beher D; Elle C; Underwood J; Davis J B; Ward R; Karran E; Masters C L; Beyreuther K; Multhaup G
Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain.
Journal of neurochemistry 1999;72(4):1564-73.
1999: Connop B P; Thies R L; Beyreuther K; Ida N; Reiner P B
Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing.
Journal of neurochemistry 1999;72(4):1457-65.
1999: Cappai R; Stewart L; Jobling M F; Thyer J M; White A R; Beyreuther K; Collins S J; Masters C L; Barrow C J
Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: implications for the mechanism of prion formation.
Biochemistry 1999;38(11):3280-4.
1999: Lichtenthaler S F; Wang R; Grimm H; Uljon S N; Masters C L; Beyreuther K
Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3053-8.
1999: Smith M J; Gardner R J; Knight M A; Forrest S M; Beyreuther K; Storey E; McLean C A; Cotton R G; Cappal R; Masters C L
Early-onset Alzheimer's disease caused by a novel mutation at codon 219 of the presenilin-1 gene.
Neuroreport 1999;10(3):503-7.
1999: Egensperger R; Weggen S; Ida N; Multhaup G; Schnabel R; Beyreuther K; Bayer T A
Reverse relationship between beta-amyloid precursor protein and beta-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease.
Acta neuropathologica 1999;97(2):113-8.
1999: Cappai R; Mok S S; Galatis D; Tucker D F; Henry A; Beyreuther K; Small D H; Masters C L
Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth.
FEBS letters 1999;442(1):95-8.
1999: Yang Y; Beyreuther K; Schmitt H P
Spatial analysis of the neuronal density of aminergic brainstem nuclei in primary neurodegenerative and vascular dementia: a comparative immunocytochemical and quantitative study using a graph method.
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 1999;19(3-4):125-38.
1999: Ren R F; Lah J J; Diehlmann A; Kim E S; Hawver D B; Levey A I; Beyreuther K; Flanders K C
Differential effects of transforming growth factor-beta(s) and glial cell line-derived neurotrophic factor on gene expression of presenilin-1 in human post-mitotic neurons and astrocytes.
Neuroscience 1999;93(3):1041-9.
1999: Multhaup G; Hesse L; Borchardt T; Ruppert T; Cappai R; Masters C L; Beyreuther K
Autoxidation of amyloid precursor protein and formation of reactive oxygen species.
Advances in experimental medicine and biology 1999;448():183-92.
1998: Tesco G; Kim T W; Diehlmann A; Beyreuther K; Tanzi R E
Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation.
The Journal of biological chemistry 1998;273(51):33909-14.
1998: Henry A; Li Q X; Galatis D; Hesse L; Multhaup G; Beyreuther K; Masters C L; Cappai R
Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein.
British journal of haematology 1998;103(2):402-15.
1998: Fossgreen A; Brückner B; Czech C; Masters C L; Beyreuther K; Paro R
Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13703-8.
1998: Weggen S; Diehlmann A; Buslei R; Beyreuther K; Bayer T A
Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer's disease brain.
Neuroreport 1998;9(14):3279-83.
1998: Le Brocque D; Henry A; Cappai R; Li Q X; Tanner J E; Galatis D; Gray C; Holmes S; Underwood J R; Beyreuther K; Masters C L; Evin G
Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gamma-secretase products.
Biochemistry 1998;37(42):14958-65.
1998: White A R; Zheng H; Galatis D; Maher F; Hesse L; Multhaup G; Beyreuther K; Masters C L; Cappai R
Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(16):6207-17.
1998: Sberna G; Sáez-Valero J; Li Q X; Czech C; Beyreuther K; Masters C L; McLean C A; Small D H
Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the beta-amyloid protein precursor of Alzheimer's disease.
Journal of neurochemistry 1998;71(2):723-31.
1998: Culvenor J G; Henry A; Hartmann T; Evin G; Galatis D; Friedhuber A; Jayasena U L; Underwood J R; Beyreuther K; Masters C L; Cappai R
Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1998;5(2):79-89.
1998: Rondot S; Anthony K G; Dübel S; Ida N; Wiemann S; Beyreuther K; Frost L S; Little M; Breitling F
Epitopes fused to F-pilin are incorporated into functional recombinant pili.
Journal of molecular biology 1998;279(3):589-603.
1998: Postuma R B; Martins R N; Cappai R; Beyreuther K; Masters C L; Strickland D K; Mok S S; Small D H
Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor-related protein on neurite outgrowth from sympathetic neurons in culture.
FEBS letters 1998;428(1-2):13-6.
1998: Simons M; Keller P; De Strooper B; Beyreuther K; Dotti C G; Simons K
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6460-4.
1998: Hass S; Fresser F; Köchl S; Beyreuther K; Utermann G; Baier G
Physical interaction of ApoE with amyloid precursor protein independent of the amyloid Abeta region in vitro.
The Journal of biological chemistry 1998;273(22):13892-7.
1998: Multhaup G; Ruppert T; Schlicksupp A; Hesse L; Bill E; Pipkorn R; Masters C L; Beyreuther K
Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide.
Biochemistry 1998;37(20):7224-30.
1998: Li Q X; Whyte S; Tanner J E; Evin G; Beyreuther K; Masters C L
Secretion of Alzheimer's disease Abeta amyloid peptide by activated human platelets.
Laboratory investigation; a journal of technical methods and pathology 1998;78(4):461-9.
1998: Zhang D; Ruan Y; Beyreuther K
[Effect of ganglioside GM1 on the metabolism of Alzheimer amyloid beta-protein precursor]
Zhonghua yi xue za zhi 1998;78(3):179-82.
1998: Masters C L; Beyreuther K
Alzheimer's disease.
BMJ (Clinical research ed.) 1998;316(7129):446-8.
1998: Moir R D; Lynch T; Bush A I; Whyte S; Henry A; Portbury S; Multhaup G; Small D H; Tanzi R E; Beyreuther K; Masters C L
Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.
The Journal of biological chemistry 1998;273(9):5013-9.
1998: Capell A; Grünberg J; Pesold B; Diehlmann A; Citron M; Nixon R; Beyreuther K; Selkoe D J; Haass C
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
The Journal of biological chemistry 1998;273(6):3205-11.
1998: Hentschel F; Zerfass R; Becker G; Beyreuther K; Förstl H
[Neuroradiological findings in Alzheimer dementia with the presenile mutation]
RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 1998;168(1):97-100.
1998: Hock C; Golombowski S; Müller-Spahn F; Naser W; Beyreuther K; Mönning U; Schenk D; Vigo-Pelfrey C; Bush A M; Moir R; Tanzi R E; Growdon J H; Nitsch R M
Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity.
European neurology 1998;39(2):111-8.
1997: Bayer T A; Paliga K; Weggen S; Wiestler O D; Beyreuther K; Multhaup G
Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease.
Acta neuropathologica 1997;94(6):519-24.
1997: Paliga K; Peraus G; Kreger S; Dürrwang U; Hesse L; Multhaup G; Masters C L; Beyreuther K; Weidemann A
Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.
European journal of biochemistry / FEBS 1997;250(2):354-63.
1997: Lichtenthaler S F; Ida N; Multhaup G; Masters C L; Beyreuther K
Mutations in the transmembrane domain of APP altering gamma-secretase specificity.
Biochemistry 1997;36(49):15396-403.
1997: Mills J; Laurent Charest D; Lam F; Beyreuther K; Ida N; Pelech S L; Reiner P B
Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(24):9415-22.
1997: Schröder J; Pantel J; Ida N; Essig M; Hartmann T; Knopp M V; Schad L R; Sandbrink R; Sauer H; Masters C L; Beyreuther K
Cerebral changes and cerebrospinal fluid beta-amyloid in Alzheimer's disease: a study with quantitative magnetic resonance imaging.
Molecular psychiatry 1997;2(6):505-7.
1997: Coulson E J; Barrett G L; Storey E; Bartlett P F; Beyreuther K; Masters C L
Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata.
Brain research 1997;770(1-2):72-80.
1997: Mok S S; Sberna G; Heffernan D; Cappai R; Galatis D; Clarris H J; Sawyer W H; Beyreuther K; Masters C L; Small D H
Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease.
FEBS letters 1997;415(3):303-7.
1997: Beyreuther K; Masters C L
Alzheimer's disease. The ins and outs of amyloid-beta.
Nature 1997;389(6652):677-8.
1997: Peraus G C; Masters C L; Beyreuther K
Late compartments of amyloid precursor protein transport in SY5Y cells are involved in beta-amyloid secretion.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7714-24.
1997: Multhaup G; Ruppert T; Schlicksupp A; Hesse L; Beher D; Masters C L; Beyreuther K
Reactive oxygen species and Alzheimer's disease.
Biochemical pharmacology 1997;54(5):533-9.
1997: Culvenor J G; Maher F; Evin G; Malchiodi-Albedi F; Cappai R; Underwood J R; Davis J B; Karran E H; Roberts G W; Beyreuther K; Masters C L
Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment.
Journal of neuroscience research 1997;49(6):719-31.
1997: Hartmann T; Bieger S C; Brühl B; Tienari P J; Ida N; Allsop D; Roberts G W; Masters C L; Dotti C G; Unsicker K; Beyreuther K
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.
Nature medicine 1997;3(9):1016-20.
1997: Sberna G; Sáez-Valero J; Beyreuther K; Masters C L; Small D H
The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells.
Journal of neurochemistry 1997;69(3):1177-84.
1997: McLean C A; Beyreuther K; Masters C L
Commentary on the consensus recommendations for the post mortem diagnosis of Alzheimer's disease.
Neurobiology of aging 1997;18(4 Suppl):S89-90.
1997: Masters C L; Beyreuther K
Spongiform encephalopathies. Tracking turncoat prion proteins.
Nature 1997;388(6639):228-9.
1997: Henry A; Masters C L; Beyreuther K; Cappai R
Expression of human amyloid precursor protein ectodomains in Pichia pastoris: analysis of culture conditions, purification, and characterization.
Protein expression and purification 1997;10(2):283-91.
1997: Czech C; Delaère P; Macq A F; Reibaud M; Dreisler S; Touchet N; Schombert B; Mazadier M; Mercken L; Theisen M; Pradier L; Octave J N; Beyreuther K; Tremp G
Proteolytical processing of mutated human amyloid precursor protein in transgenic mice.
Brain research. Molecular brain research 1997;47(1-2):108-16.
1997: Beyreuther K; Masters C L
Serpents on the road to dementia and death. Accumulating evidence from several studies points to the normal function of presenilin 1 and suggests how the mutant protein contributes to deposition of amyloid plaques in Alzheimer's disease.
Nature medicine 1997;3(7):723-5.
1997: Tienari P J; Ida N; Ikonen E; Simons M; Weidemann A; Multhaup G; Masters C L; Dotti C G; Beyreuther K
Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):4125-30.
1997: Weidemann A; Paliga K; Dürrwang U; Czech C; Evin G; Masters C L; Beyreuther K
Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein.
Nature medicine 1997;3(3):328-32.
1997: Clarris H J; Cappai R; Heffernan D; Beyreuther K; Masters C L; Small D H
Identification of heparin-binding domains in the amyloid precursor protein of Alzheimer's disease by deletion mutagenesis and peptide mapping.
Journal of neurochemistry 1997;68(3):1164-72.
1997: Whyte S; Wilson N; Currie J; Maruff P; Malone V; Shafiq-Antonacci R; Tyler P; Derry K L; Underwood J; Li Q X; Beyreuther K; Masters C L
Collection and normal levels of the amyloid precursor protein in plasma.
Annals of neurology 1997;41(1):121-4.
1997: Mok S S; Evin G; Li Q X; Smith A I; Beyreuther K; Masters C L; Small D H
A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments.
Biochemistry 1997;36(1):156-63.
1997: Drache B; Diehl G E; Beyreuther K; Perlmutter L S; König G
Bcl-xl-specific antibody labels activated microglia associated with Alzheimer's disease and other pathological states.
Journal of neuroscience research 1997;47(1):98-108.
1997: Sandbrink R; Mönning U; Masters C L; Beyreuther K
Expression of the APP gene family in brain cells, brain development and aging.
Gerontology 1997;43(1-2):119-31.
1996: Sandbrink R; Beyreuther K
Unraveling the molecular pathway of Alzheimer's disease: research about presenilins gathers momentum.
Molecular psychiatry 1996;1(6):438-44.
1996: Williamson T G; Mok S S; Henry A; Cappai R; Lander A D; Nurcombe V; Beyreuther K; Masters C L; Small D H
Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth.
The Journal of biological chemistry 1996;271(49):31215-21.
1996: Storey E; Beyreuther K; Masters C L
Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components.
Brain research 1996;735(2):217-31.
1996: Tienari P J; De Strooper B; Ikonen E; Simons M; Weidemann A; Czech C; Hartmann T; Ida N; Multhaup G; Masters C L; Van Leuven F; Beyreuther K; Dotti C G
The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.
The EMBO journal 1996;15(19):5218-29.
1996: Beyreuther K; Masters C L
Alzheimer's disease. Tangle disentanglement.
Nature 1996;383(6600):476-7.
1996: Förstl H; Sattel H; Sarochan M; Besthom C; Czech C; Daniel S; Geiger-Kabisch C; Hentschel F; Zerfass R; Beyreuther K
[Alzheimer dementia and normal aging. Clinical, neuroradiologic, neurophysiologic and molecular biology follow-up data]
Der Nervenarzt 1996;67(9):730-8.
1996: Storey E; Spurck T; Pickett-Heaps J; Beyreuther K; Masters C L
The amyloid precursor protein of Alzheimer's disease is found on the surface of static but not activity motile portions of neurites.
Brain research 1996;735(1):59-66.
1996: Ida N; Masters C L; Beyreuther K
Rapid cellular uptake of Alzheimer amyloid betaA4 peptide by cultured human neuroblastoma cells.
FEBS letters 1996;394(2):174-8.
1996: Ida N; Hartmann T; Pantel J; Schröder J; Zerfass R; Förstl H; Sandbrink R; Masters C L; Beyreuther K
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.
The Journal of biological chemistry 1996;271(37):22908-14.
1996: Bayer T A; Fossgreen A; Czech C; Beyreuther K; Wiestler O D
Plaque formation in brain transplants exposed to human beta-amyloid precursor protein 695.
Acta neuropathologica 1996;92(2):130-7.
1996: Sandbrink R; Zhang D; Schaeffer S; Masters C L; Bauer J; Förstl H; Beyreuther K
Missense mutations of the PS-1/S182 gene in German early-onset Alzheimer's disease patients.
Annals of neurology 1996;40(2):265-6.
1996: Hartmann T; Bergsdorf C; Sandbrink R; Tienari P J; Multhaup G; Ida N; Bieger S; Dyrks T; Weidemann A; Masters C L; Beyreuther K
Alzheimer's disease betaA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing.
The Journal of biological chemistry 1996;271(22):13208-14.
1996: Sandbrink R; Hartmann T; Masters C L; Beyreuther K
Genes contributing to Alzheimer's disease.
Molecular psychiatry 1996;1(1):27-40.
1996: Sarochan M; Förstl H; Sattel H; Zerfass R; Czech C; Beyreuther K
Apolipoprotein E genotype does not promote the clinical progression of manifest Alzheimer's disease.
Dementia (Basel, Switzerland) 1996;7(2):120.
1996: Thilmann P; Ernst C; Czech C; Kaumeier S; Beyreuther K; Förstl H
Low apolipoprotein E4 allelic frequency in Alzheimer's disease and functional psychiatric disorders.
Dementia (Basel, Switzerland) 1996;7(2):118-9.
1996: Multhaup G; Schlicksupp A; Hesse L; Beher D; Ruppert T; Masters C L; Beyreuther K
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)
Science (New York, N.Y.) 1996;271(5254):1406-9.
1996: Simons M; de Strooper B; Multhaup G; Tienari P J; Dotti C G; Beyreuther K
Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(3):899-908.
1996: Beyreuther K; Multhaup G; Mönning U; Sandbrink R; Beher D; Hesse L; Small D H; Masters C L
Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines.
Annals of the New York Academy of Sciences 1996;777():74-6.
1996: Small D H; Williamson T; Reed G; Clarris H; Beyreuther K; Masters C L; Nurcombe V
The role of heparan sulfate proteoglycans in the pathogenesis of Alzheimer's disease.
Annals of the New York Academy of Sciences 1996;777():316-21.
1996: Sandbrink R; Masters C L; Beyreuther K
APP gene family. Alternative splicing generates functionally related isoforms.
Annals of the New York Academy of Sciences 1996;777():281-7.
1996: Tienari P J; De Strooper B; Ikonen E; Ida N; Simons M; Masters C L; Dotti C G; Beyreuther K
Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease.
Cold Spring Harbor symposia on quantitative biology 1996;61():575-85.
1996: Beyreuther K; Multhaup G; Masters C L
Alzheimer's disease: genesis of amyloid.
Ciba Foundation symposium 1996;199():119-27; discussion 127-31.
1995: LePage R N; Fosang A J; Fuller S J; Murphy G; Evin G; Beyreuther K; Masters C L; Small D H
Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease.
FEBS letters 1995;377(2):267-70.
1995: Williamson T G; Nurcombe V; Beyreuther K; Masters C L; Small D H
Affinity purification of proteoglycans that bind to the amyloid protein precursor of Alzheimer's disease.
Journal of neurochemistry 1995;65(5):2201-8.
1995: Sticht H; Bayer P; Willbold D; Dames S; Hilbich C; Beyreuther K; Frank R W; Rösch P
Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease.
European journal of biochemistry / FEBS 1995;233(1):293-8.
1995: De Strooper B; Simons M; Multhaup G; Van Leuven F; Beyreuther K; Dotti C G
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.
The EMBO journal 1995;14(20):4932-8.
1995: Evin G; Cappai R; Li Q X; Culvenor J G; Small D H; Beyreuther K; Masters C L
Candidate gamma-secretases in the generation of the carboxyl terminus of the Alzheimer's disease beta A4 amyloid: possible involvement of cathepsin D.
Biochemistry 1995;34(43):14185-92.
1995: Culvenor J G; Friedhuber A; Fuller S J; Beyreuther K; Masters C L
Expression of the amyloid precursor protein of Alzheimer's disease on the surface of transfected HeLa cells.
Experimental cell research 1995;220(2):474-81.
1995: Clarris H J; Key B; Beyreuther K; Masters C L; Small D H
Expression of the amyloid protein precursor of Alzheimer's disease in the developing rat olfactory system.
Brain research. Developmental brain research 1995;88(1):87-95.
1995: Simons M; Tienari P J; Dotti C G; Beyreuther K
Two-dimensional gel mapping of the processing of the human amyloid precursor protein in rat hippocampal neurons.
FEBS letters 1995;368(2):363-6.
1995: Fuller S J; Storey E; Li Q X; Smith A I; Beyreuther K; Masters C L
Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein.
Biochemistry 1995;34(25):8091-8.
1995: Li Q X; Evin G; Small D H; Multhaup G; Beyreuther K; Masters C L
Proteolytic processing of Alzheimer's disease beta A4 amyloid precursor protein in human platelets.
The Journal of biological chemistry 1995;270(23):14140-7.
1995: Meyer-Franke A; Tropak M B; Roder J C; Fischer P; Beyreuther K; Probstmeier R; Schachner M
Functional topography of myelin-associated glycoprotein. II. Mapping of domains on molecular fragments.
Journal of neuroscience research 1995;41(3):311-23.
1995: Simons M; Ikonen E; Tienari P J; Cid-Arregui A; Mönning U; Beyreuther K; Dotti C G
Intracellular routing of human amyloid protein precursor: axonal delivery followed by transport to the dendrites.
Journal of neuroscience research 1995;41(1):121-8.
1995: Zhan S S; Sandbrink R; Beyreuther K; Schmitt H P
APP with Kunitz type protease inhibitor domain (KPI) correlates with neuritic plaque density but not with cortical synaptophysin immunoreactivity in Alzheimer's disease and non-demented aged subjects: a multifactorial analysis.
Clinical neuropathology 1995;14(3):142-9.
1995: Eckert A; Förstl H; Hartmann H; Czech C; Mönning U; Beyreuther K; Müller W E
The amplifying effect of beta-amyloid on cellular calcium signalling is reduced in Alzheimer's disease.
Neuroreport 1995;6(8):1199-202.
1995: Evin G; Beyreuther K; Masters C L
A synthetic substrate assay for the gamma-secretase of the beta-A4 amyloid of Alzheimer's disease.
Journal of peptide science : an official publication of the European Peptide Society 1995;1(2):132-9.
1995: Masters C L; Beyreuther K
Molecular neuropathology of Alzheimer's disease.
Arzneimittel-Forschung 1995;45(3A):410-2.
1995: Förstl H; Hentschel F; Sattel H; Geiger-Kabisch C; Besthorn C; Czech C; Mönning U; Beyreuther K
Age-associated memory impairment and early Alzheimer's disease. Only time will tell the difference.
Arzneimittel-Forschung 1995;45(3A):394-7.
1995: Beyreuther K; Masters C L
Neurodegeneration and dementia. Alzheimer's disease as a model.
Arzneimittel-Forschung 1995;45(3A):347-50.
1995: Mönning U; Sandbrink R; Weidemann A; Banati R B; Masters C L; Beyreuther K
Extracellular matrix influences the biogenesis of amyloid precursor protein in microglial cells.
The Journal of biological chemistry 1995;270(13):7104-10.
1995: Beer J; Masters C L; Beyreuther K
Cells from peripheral tissues that exhibit high APP expression are characterized by their high membrane fusion activity.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1995;4(1):51-9.
1995: Urmoneit B; Reinsch C; Turner J; Czech C; Beyreuther K; Dyrks T
Inhibition of beta A4 production by specific modulation of beta-secretase activity.
Journal of molecular neuroscience : MN 1995;6(1):23-32.
1994: Sandbrink R; Masters C L; Beyreuther K
APP gene family: unique age-associated changes in splicing of Alzheimer's betaA4-amyloid protein precursor.
Neurobiology of disease 1994;1(1-2):13-24.
1994: Förstl H; Czech C; Sattel H; Geiger-Kabisch C; Besthorn C; Kreger S; Mönning U; Hartmann T; Masters C; Beyreuther K
[Apolipoprotein E and Alzheimer dementia. Personal results and brief literature review]
Der Nervenarzt 1994;65(11):780-6.
1994: Sandbrink R; Masters C L; Beyreuther K
Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): two amino acids length difference to human and murine homologues.
Biochimica et biophysica acta 1994;1219(1):167-70.
1994: Bush A I; Pettingell W H; Multhaup G; d Paradis M; Vonsattel J P; Gusella J F; Beyreuther K; Masters C L; Tanzi R E
Rapid induction of Alzheimer A beta amyloid formation by zinc.
Science (New York, N.Y.) 1994;265(5177):1464-7.
1994: Dyrks T; Mönning U; Beyreuther K; Turner J
Amyloid precursor protein secretion and beta A4 amyloid generation are not mutually exclusive.
FEBS letters 1994;349(2):210-4.
1994: Beyreuther K; Masters C L
Neurobiology. Catching the culprit prion.
Nature 1994;370(6489):419-20.
1994: Li Q X; Berndt M C; Bush A I; Rumble B; Mackenzie I; Friedhuber A; Beyreuther K; Masters C L
Membrane-associated forms of the beta A4 amyloid protein precursor of Alzheimer's disease in human platelet and brain: surface expression on the activated human platelet.
Blood 1994;84(1):133-42.
1994: Clarris H J; Nurcombe V; Small D H; Beyreuther K; Masters C L
Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants.
Journal of neuroscience research 1994;38(3):248-58.
1994: Sandbrink R; Masters C L; Beyreuther K
Similar alternative splicing of a non-homologous domain in beta A4-amyloid protein precursor-like proteins.
The Journal of biological chemistry 1994;269(19):14227-34.
1994: Small D H; Nurcombe V; Reed G; Clarris H; Moir R; Beyreuther K; Masters C L
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(4):2117-27.
1994: Mönning U; Sandbrink R; Banati R B; Masters C L; Beyreuther K
Transforming growth factor beta mediates increase of mature transmembrane amyloid precursor protein in microglial cells.
FEBS letters 1994;342(3):267-72.
1994: Banati R B; Gehrmann J; Mönning U; Czech C; Beyreuther K; Kreutzberg G W
Amyloid precursor protein (APP) as a microglial acute phase protein.
Neuropathology and applied neurobiology 1994;20(2):194-5.
1994: Masters C L; Beyreuther K
Alzheimer's disease: a clearer definition of the genetic components.
The Medical journal of Australia 1994;160(5):243-4.
1994: Zhan S S; Beyreuther K; Schmitt H P
Synaptophysin immunoreactivity of the cortical neuropil in vascular dementia of Binswanger type compared with the dementia of Alzheimer type and nondemented controls.
Dementia (Basel, Switzerland) 1994;5(2):79-87.
1994: Sandbrink R; Masters C L; Beyreuther K
Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons.
The Journal of biological chemistry 1994;269(2):1510-7.
1994: Osuntokun B O; Ogunniyi A; Akang E E; Aghadiuno P U; Ilori A; Bamgboye E A; Beyreuther K; Masters C
Beta A4-amyloid in the brains of non-demented Nigerian Africans.
Lancet 1994;343(8888):56.
1994: Czech C; Förstl H; Hentschel F; Mönning U; Besthorn C; Geiger-Kabisch C; Sattel H; Masters C; Beyreuther K
Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change.
European archives of psychiatry and clinical neuroscience 1994;243(5):291-2.
1994: Czech C; Masters C; Beyreuther K
Alzheimer's disease and transgenic mice.
Journal of neural transmission. Supplementum 1994;44():219-30.
1993: Seelig A; Multhaup G; Pesold-Hurt B; Beyreuther K; Kloetzel P M
Drosophila proteasome Dm25 subunit substitutes the mouse MC3 subunit in hybrid proteasomes. The N-terminal domain is essential for subunit incorporation.
The Journal of biological chemistry 1993;268(34):25561-7.
1993: Schubert W; Masters C L; Beyreuther K
APP+ T lymphocytes selectively sorted to endomysial tubes in polymyositis displace NCAM-expressing muscle fibers.
European journal of cell biology 1993;62(2):333-42.
1993: Hilbich C; Mönning U; Grund C; Masters C L; Beyreuther K
Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11.
The Journal of biological chemistry 1993;268(35):26571-7.
1993: Dyrks T; Dyrks E; Mönning U; Urmoneit B; Turner J; Beyreuther K
Generation of beta A4 from the amyloid protein precursor and fragments thereof.
FEBS letters 1993;335(1):89-93.
1993: Dichgans M; Mönning U; König G; Sandbrink R; Masters C L; Beyreuther K
APP expression in primary neuronal cell cultures from P6 mice during in vitro differentiation.
Dementia (Basel, Switzerland) 1993;4(6):301-7.
1993: Czech C; Mönning V; Tienari P J; Hartmann T; Masters C; Beyreuther K; Förstl H
Apolipoprotein E-epsilon 4 allele and Alzheimer's disease.
Lancet 1993;342(8882):1309.
1993: Banati R B; Gehrmann J; Czech C; Mönning U; Jones L L; König G; Beyreuther K; Kreutzberg G W
Early and rapid de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia.
Glia 1993;9(3):199-210.
1993: Beyreuther K; Pollwein P; Multhaup G; Mönning U; König G; Dyrks T; Schubert W; Masters C L
Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome.
Annals of the New York Academy of Sciences 1993;695():91-102.
1993: Sandbrink R; Banati R; Masters C L; Beyreuther K; König G
Expression of L-APP mRNA in brain cells.
Annals of the New York Academy of Sciences 1993;695():183-9.
1993: Bush A I; Beyreuther K; Masters C L
The beta A4 amyloid protein precursor in human circulation.
Annals of the New York Academy of Sciences 1993;695():175-82.
1993: Small D H; Nurcombe V; Clarris H; Beyreuther K; Masters C L
The role of extracellular matrix in the processing of the amyloid protein precursor of Alzheimer's disease.
Annals of the New York Academy of Sciences 1993;695():169-74.
1993: Bush A I; Multhaup G; Moir R D; Williamson T G; Small D H; Rumble B; Pollwein P; Beyreuther K; Masters C L
A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.
The Journal of biological chemistry 1993;268(22):16109-12.
1993: Dyrks T; Dyrks E; Masters C L; Beyreuther K
Amyloidogenicity of rodent and human beta A4 sequences.
FEBS letters 1993;324(2):231-6.
1993: Zhan S S; Beyreuther K; Schmitt H P
Quantitative assessment of the synaptophysin immuno-reactivity of the cortical neuropil in various neurodegenerative disorders with dementia.
Dementia (Basel, Switzerland) 1993;4(2):66-74.
1993: Multhaup G; Masters C L; Beyreuther K
A molecular approach to Alzheimer's disease.
Biological chemistry Hoppe-Seyler 1993;374(1):1-8.
1993: Gearing M; Wilson R W; Unger E R; Shelton E R; Chan H W; Masters C L; Beyreuther K; Mirra S S
Amyloid precursor protein (APP) in the striatum in Alzheimer's disease: an immunohistochemical study.
Journal of neuropathology and experimental neurology 1993;52(1):22-30.
1993: Guiroy D C; Mellini M; Miyazaki M; Hilbich C; Safar J; Garruto R M; Yanagihara R; Beyreuther K; Gajdusek D C
Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4- to 4.5-kilodalton protein which is immunoreactive to anti-amyloid beta/A4-protein antibodies.
Acta neuropathologica 1993;86(3):265-74.
1993: Zhan S S; Beyreuther K; Schmitt H P
Vascular dementia in Spatz-Lindenberg's disease (SLD): cortical synaptophysin immunoreactivity as compared with dementia of Alzheimer type and non-demented controls.
Acta neuropathologica 1993;86(3):259-64.
1992: Hilbich C; Kisters-Woike B; Reed J; Masters C L; Beyreuther K
Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides.
Journal of molecular biology 1992;228(2):460-73.
1992: Mönning U; König G; Banati R B; Mechler H; Czech C; Gehrmann J; Schreiter-Gasser U; Masters C L; Beyreuther K
Alzheimer beta A4-amyloid protein precursor in immunocompetent cells.
The Journal of biological chemistry 1992;267(33):23950-6.
1992: Woehlke G; Laussermair E; Schwarz E; Oesterhelt D; Reinke H; Beyreuther K; Dimroth P
Appendix. Sequence of the beta-subunit of oxaloacetate decarboxylase from Klebsiella pneumoniae: a correction of the C-terminal part.
The Journal of biological chemistry 1992;267(32):22804-5.
1992: Small D H; Nurcombe V; Moir R; Michaelson S; Monard D; Beyreuther K; Masters C L
Association and release of the amyloid protein precursor of Alzheimer's disease from chick brain extracellular matrix.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(11):4143-50.
1992: Moir R D; Martins R N; Bush A I; Small D H; Milward E A; Rumble B A; Multhaup G; Beyreuther K; Masters C L
Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization.
Journal of neurochemistry 1992;59(4):1490-8.
1992: Dyrks T; Dyrks E; Hartmann T; Masters C; Beyreuther K
Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.
The Journal of biological chemistry 1992;267(25):18210-7.
1992: Zhan S S; Beyreuther K; Schmitt H P
Neuronal ubiquitin and neurofilament expression in different lysosomal storage disorders.
Clinical neuropathology 1992;11(5):251-5.
1992: Dyrks T; Dyrks E; Masters C; Beyreuther K
Membrane inserted APP fragments containing the beta A4 sequence of Alzheimer's disease do not aggregate.
FEBS letters 1992;309(1):20-4.
1992: Milward E A; Papadopoulos R; Fuller S J; Moir R D; Small D; Beyreuther K; Masters C L
The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth.
Neuron 1992;9(1):129-37.
1992: Prior P; Schmitt B; Grenningloh G; Pribilla I; Multhaup G; Beyreuther K; Maulet Y; Werner P; Langosch D; Kirsch J
Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein.
Neuron 1992;8(6):1161-70.
1992: König G; Mönning U; Czech C; Prior R; Banati R; Schreiter-Gasser U; Bauer J; Masters C L; Beyreuther K
Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.
The Journal of biological chemistry 1992;267(15):10804-9.
1992: Candy J M; McArthur F K; Oakley A E; Taylor G A; Chen C P; Mountfort S A; Thompson J E; Chalker P R; Bishop H E; Beyreuther K
Aluminium accumulation in relation to senile plaque and neurofibrillary tangle formation in the brains of patients with renal failure.
Journal of the neurological sciences 1992;107(2):210-8.
1992: Pollwein P; Masters C L; Beyreuther K
The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter.
Nucleic acids research 1992;20(1):63-8.
1992: Soininen H; Syrjänen S; Heinonen O; Neittaanmäki H; Miettinen R; Paljärvi L; Syrjänen K; Beyreuther K; Riekkinen P
Amyloid beta-protein deposition in skin of patients with dementia.
Lancet 1992;339(8787):245.
1992: Beyreuther K; Dyrks T; Hilbich C; Mönning U; König G; Multhaup G; Pollwein P; Masters C L
Amyloid precursor protein (APP) and beta A4 amyloid in Alzheimer's disease and Down syndrome.
Progress in clinical and biological research 1992;379():159-82.
1992: Bush A I; Beyreuther K; Masters C L
Beta A4 amyloid protein and its precursor in Alzheimer's disease.
Pharmacology & therapeutics 1992;56(1):97-117.
1991: Yamaguchi F; Richards S J; Beyreuther K; Salbaum M; Carlson G A; Dunnett S B
Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory.
Neuroreport 1991;2(12):781-4.
1991: Ohgami T; Kitamoto T; Weidmann A; Beyreuther K; Tateishi J
Alzheimer's amyloid precursor protein-positive degenerative neurites exist even within kuru plaques not specific to Alzheimer's disease.
The American journal of pathology 1991;139(6):1245-50.
1991: Schubert W; Prior R; Weidemann A; Dircksen H; Multhaup G; Masters C L; Beyreuther K
Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites.
Brain research 1991;563(1-2):184-94.
1991: Small D H; Moir R D; Fuller S J; Michaelson S; Bush A I; Li Q X; Milward E; Hilbich C; Weidemann A; Beyreuther K
A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease.
Biochemistry 1991;30(44):10795-9.
1991: Hilbich C; Kisters-Woike B; Reed J; Masters C L; Beyreuther K
Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4.
European journal of biochemistry / FEBS 1991;201(1):61-9.
1991: Dahr W; Knuppertz G; Beyreuther K; Moulds J J; Moulds M; Wilkinson S; Capon C; Fournet B; Issitt P D
Studies on the structures of the Tm, Sj, M1, Can, Sext and Hu blood group antigens.
Biological chemistry Hoppe-Seyler 1991;372(8):573-84.
1991: Beyreuther K; Masters C L
Amyloid precursor protein (APP) and beta A4 amyloid in the etiology of Alzheimer's disease: precursor-product relationships in the derangement of neuronal function.
Brain pathology (Zurich, Switzerland) 1991;1(4):241-51.
1991: Masters C L; Beyreuther K
Alzheimer's disease: molecular basis of structural lesions.
Brain pathology (Zurich, Switzerland) 1991;1(4):226-7.
1991: Le Coz P; Mikol J; Ferrand J; Woimant F; Masters C; Beyreuther K; Haguenau M; Cophignon J; Pepin B
Granulomatous angiitis and cerebral amyloid angiopathy presenting as a mass lesion.
Neuropathology and applied neurobiology 1991;17(2):149-55.
1991: Ganter U; Strauss S; Jonas U; Weidemann A; Beyreuther K; Volk B; Berger M; Bauer J
Alpha 2-macroglobulin synthesis in interleukin-6-stimulated human neuronal (SH-SY5Y neuroblastoma) cells. Potential significance for the processing of Alzheimer beta-amyloid precursor protein.
FEBS letters 1991;282(1):127-31.
1991: Kitamoto T; Muramoto T; Hilbich C; Beyreuther K; Tateishi J
N-terminal sequence of prion protein is also integrated into kuru plaques in patients with Gerstmann-Sträussler syndrome.
Brain research 1991;545(1-2):319-21.
1991: Hilbich C; Kisters-Woike B; Reed J; Masters C L; Beyreuther K
Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease.
Journal of molecular biology 1991;218(1):149-63.
1991: Prior R; Mönning U; Schreiter-Gasser U; Weidemann A; Blennow K; Gottfries C G; Masters C L; Beyreuther K
Quantitative changes in the amyloid beta A4 precursor protein in Alzheimer cerebrospinal fluid.
Neuroscience letters 1991;124(1):69-73.
1991: Martin L J; Sisodia S S; Koo E H; Cork L C; Dellovade T L; Weidemann A; Beyreuther K; Masters C; Price D L
Amyloid precursor protein in aged nonhuman primates.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1461-5.
1991: Richards S J; Waters J J; Beyreuther K; Masters C L; Wischik C M; Sparkman D R; White C L; Abraham C R; Dunnett S B
Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology.
The EMBO journal 1991;10(2):297-303.
1991: König G; Salbaum J M; Wiestler O; Lang W; Schmitt H P; Masters C L; Beyreuther K
Alternative splicing of the beta A4 amyloid gene of Alzheimer's disease in cortex of control and Alzheimer's disease patients.
Brain research. Molecular brain research 1991;9(3):259-62.
1991: Martin J J; Gheuens J; Bruyland M; Cras P; Vandenberghe A; Masters C L; Beyreuther K; Dom R; Ceuterick C; Lübke U
Early-onset Alzheimer's disease in 2 large Belgian families.
Neurology 1991;41(1):62-8.
1991: Gajdusek D C; Beyreuther K; Brown P; Cork L C; Cunningham D D; Frangione B; Gibbs C J; Goldfarb L G; Goldgaber D; Hsiao K K
Regulation and genetic control of brain amyloid. FESN Study Group.
Brain research. Brain research reviews 1991;16(1):83-114.
1991: Martins R N; Robinson P J; Chleboun J O; Beyreuther K; Masters C L
The molecular pathology of amyloid deposition in Alzheimer's disease.
Molecular neurobiology 1991;5(2-4):389-98.
1991: Beyreuther K
[First steps against Alzheimer's]
Zahntechnik (Zurich, Switzerland) 1991;48(5):408-11.
1991: Beyreuther K; Bush A I; Dyrks T; Hilbich C; König G; Mönning U; Multhaup G; Prior R; Rumble B; Schubert W
Mechanisms of amyloid deposition in Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():129-39.
1990: Mönning U; König G; Prior R; Mechler H; Schreiter-Gasser U; Masters C L; Beyreuther K
Synthesis and secretion of Alzheimer amyloid beta A4 precursor protein by stimulated human peripheral blood leucocytes.
FEBS letters 1990;277(1-2):261-6.
1990: Cork L C; Masters C; Beyreuther K; Price D L
Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits.
The American journal of pathology 1990;137(6):1383-92.
1990: Sorimachi K; Craik D J; Lloyd E J; Beyreuther K; Masters C L
Identification of a beta-turn in the tertiary structure of a peptide fragment of the Alzheimer amyloid protein.
Biochemistry international 1990;22(3):447-54.
1990: König G; Masters C L; Beyreuther K
Retinoic acid induced differentiated neuroblastoma cells show increased expression of the beta A4 amyloid gene of Alzheimer's disease and an altered splicing pattern.
FEBS letters 1990;269(2):305-10.
1990: Delaère P; Duyckaerts C; Masters C; Beyreuther K; Piette F; Hauw J J
Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person.
Neuroscience letters 1990;116(1-2):87-93.
1990: Malherbe P; Draguhn A; Multhaup G; Beyreuther K; Möhler H
GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAs displays potentiation by benzodiazepine receptor ligands.
Brain research. Molecular brain research 1990;8(3):199-208.
1990: Catteruccia N; Willingale-Theune J; Bunke D; Prior R; Masters C L; Crisanti A; Beyreuther K
Ultrastructural localization of the putative precursors of the A4 amyloid protein associated with Alzheimer's disease.
The American journal of pathology 1990;137(1):19-26.
1990: Van den Brande J L; Hoogerbrugge C M; Beyreuther K; Roepstorff P; Jansen J; van Buul-Offers S C
Isolation and partial characterization of IGF-like peptides from Cohn fraction IV of human plasma.
Acta endocrinologica 1990;122(6):683-95.
1990: Haass C; Pesold-Hurt B; Multhaup G; Beyreuther K; Kloetzel P M
The Drosophila PROS-28.1 gene is a member of the proteasome gene family.
Gene 1990;90(2):235-41.
1990: Grenningloh G; Pribilla I; Prior P; Multhaup G; Beyreuther K; Taleb O; Betz H
Cloning and expression of the 58 kd beta subunit of the inhibitory glycine receptor.
Neuron 1990;4(6):963-70.
1990: Dahr W; Blanchard D; Chevalier C; Cartron J P; Beyreuther K; Fournet B
The Mz variety of the St(a+) phenotype--a variant of glycophorin A exhibiting a deletion.
Biological chemistry Hoppe-Seyler 1990;371(5):403-10.
1990: Rupp R A; Kruse U; Multhaup G; Göbel U; Beyreuther K; Sippel A E
Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes.
Nucleic acids research 1990;18(9):2607-16.
1990: Goldmann W; Hunter N; Foster J D; Salbaum J M; Beyreuther K; Hope J
Two alleles of a neural protein gene linked to scrapie in sheep.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2476-80.
1990: Sisodia S S; Koo E H; Beyreuther K; Unterbeck A; Price D L
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.
Science (New York, N.Y.) 1990;248(4954):492-5.
1990: Koo E H; Sisodia S S; Archer D R; Martin L J; Weidemann A; Beyreuther K; Fischer P; Masters C L; Price D L
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1561-5.
1990: Beyreuther K; Masters C L
Nomenclature of amyloid A4 proteins and their precursors in Alzheimer's disease and Down's syndrome.
Neurobiology of aging 1990;11(1):66-8.
1990: Walker L C; Masters C; Beyreuther K; Price D L
Amyloid in the brains of aged squirrel monkeys.
Acta neuropathologica 1990;80(4):381-7.
1990: Richards S J; Waters J J; Rogers D C; Martel F L; Sparkman D R; White C L; Beyreuther K; Masters C L; Dunnett S B
Hippocampal grafts derived from embryonic trisomy 16 mice exhibit amyloid (A4) and neurofibrillary pathology.
Progress in brain research 1990;82():215-23.
1990: Masters C L; Beyreuther K
Protein abnormalities in neurofibrillary tangles: their relation to the extracellular amyloid deposits of the A4 protein in Alzheimer's disease.
Advances in neurology 1990;51():151-61.
1989: Rozemuller J M; Eikelenboom P; Stam F C; Beyreuther K; Masters C L
A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition.
Journal of neuropathology and experimental neurology 1989;48(6):674-91.
1989: Ghetti B; Tagliavini F; Masters C L; Beyreuther K; Giaccone G; Verga L; Farlow M R; Conneally P M; Dlouhy S R; Azzarelli B
Gerstmann-Sträussler-Scheinker disease. II. Neurofibrillary tangles and plaques with PrP-amyloid coexist in an affected family.
Neurology 1989;39(11):1453-61.
1989: Laussermair E; Schwarz E; Oesterhelt D; Reinke H; Beyreuther K; Dimroth P
The sodium ion translocating oxaloacetate decarboxylase of Klebsiella pneumoniae. Sequence of the integral membrane-bound subunits beta and gamma.
The Journal of biological chemistry 1989;264(25):14710-5.
1989: el-Maliki B; Blanchard D; Dahr W; Beyreuther K; Cartron J P
Structural homology between glycophorins C and D of human erythrocytes.
European journal of biochemistry / FEBS 1989;183(3):639-43.
1989: Dahr W; Vengelen-Tyler V; Dybkjaer E; Beyreuther K
Structural analysis of glycophorin A from Miltenberger class VIII erythrocytes.
Biological chemistry Hoppe-Seyler 1989;370(8):855-9.
1989: Haass C; Pesold-Hurt B; Multhaup G; Beyreuther K; Kloetzel P M
The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome.
The EMBO journal 1989;8(8):2373-9.
1989: Hyman B T; Van Hoesen G W; Beyreuther K; Masters C L
A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles.
Neuroscience letters 1989;101(3):352-5.
1989: Nochlin D; Sumi S M; Bird T D; Snow A D; Leventhal C M; Beyreuther K; Masters C L
Familial dementia with PrP-positive amyloid plaques: a variant of Gerstmann-Sträussler syndrome.
Neurology 1989;39(7):910-8.
1989: Rumble B; Retallack R; Hilbich C; Simms G; Multhaup G; Martins R; Hockey A; Montgomery P; Beyreuther K; Masters C L
Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.
The New England journal of medicine 1989;320(22):1446-52.
1989: Dahr W; Pilkington P M; Reinke H; Blanchard D; Beyreuther K
A novel variety of the Dantu gene complex (DantuMD) detected in a Caucasian.
Blut 1989;58(5):247-53.
1989: Weidemann A; König G; Bunke D; Fischer P; Salbaum J M; Masters C L; Beyreuther K
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.
Cell 1989;57(1):115-26.
1989: Lemaire H G; Salbaum J M; Multhaup G; Kang J; Bayney R M; Unterbeck A; Beyreuther K; Müller-Hill B
The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons.
Nucleic acids research 1989;17(2):517-22.
1989: Mastaglia F L; Masters C L; Beyreuther K; Kakulas B A
Deposition of Alzheimer's disease amyloid (A4) protein in the cerebral cortex in Parkinson's disease.
Progress in clinical and biological research 1989;317():475-84.
1989: Salbaum J M; Weidemann A; Masters C L; Beyreuther K
The promoter of Alzheimer's disease amyloid A4 precursor gene.
Progress in clinical and biological research 1989;317():277-83.
1989: Müller-Hill B; Beyreuther K
Molecular biology of Alzheimer's disease.
Annual review of biochemistry 1989;58():287-307.
1989: Dyrks T; König G; Hilbich C; Masters C L; Beyreuther K
Molecular pathology of the amyloid A4 precursor of Alzheimer's disease.
Progress in clinical and biological research 1989;317():877-91.
1989: König G; Beyreuther K; Masters C L; Schmitt H P; Salbaum J M
PreA4 mRNA distribution in brain areas.
Progress in clinical and biological research 1989;317():1027-36.
1988: Münch S; Ljungberg U; Steppuhn J; Schneiderbauer A; Nechushtai R; Beyreuther K; Herrmann R G
Nucleotide sequences of cDNAs encoding the entire precursor polypeptides for subunits II and III of the photosystem I reaction center from spinach.
Current genetics 1988;14(5):511-8.
1988: Davies L; Wolska B; Hilbich C; Multhaup G; Martins R; Simms G; Beyreuther K; Masters C L
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques.
Neurology 1988;38(11):1688-93.
1988: Hope J; Reekie L J; Hunter N; Multhaup G; Beyreuther K; White H; Scott A C; Stack M J; Dawson M; Wells G A
Fibrils from brains of cows with new cattle disease contain scrapie-associated protein.
Nature 1988;336(6197):390-2.
1988: Salbaum J M; Weidemann A; Lemaire H G; Masters C L; Beyreuther K
The promoter of Alzheimer's disease amyloid A4 precursor gene.
The EMBO journal 1988;7(9):2807-13.
1988: Kutchan T M; Hampp N; Lottspeich F; Beyreuther K; Zenk M H
The cDNA clone for strictosidine synthase from Rauvolfia serpentina. DNA sequence determination and expression in Escherichia coli.
FEBS letters 1988;237(1-2):40-4.
1988: Bloy C; Blanchard D; Dahr W; Beyreuther K; Salmon C; Cartron J P
Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains.
Blood 1988;72(2):661-6.
1988: Gäde G; Hilbich C; Beyreuther K; Rinehart K L
Sequence analyses of two neuropeptides of the AKH/RPCH-family from the lubber grasshopper, Romalea microptera.
Peptides 1988;9(4):681-8.
1988: Lautner A; Klein R; Ljungberg U; Reiländer H; Bartling D; Andersson B; Reinke H; Beyreuther K; Herrmann R G
Nucleotide sequence of cDNA clones encoding the complete precursor for the "10-kDa" polypeptide of photosystem II from spinach.
The Journal of biological chemistry 1988;263(21):10077-81.
1988: Schwarz E; Oesterhelt D; Reinke H; Beyreuther K; Dimroth P
The sodium ion translocating oxalacetate decarboxylase of Klebsiella pneumoniae. Sequence of the biotin-containing alpha-subunit and relationship to other biotin-containing enzymes.
The Journal of biological chemistry 1988;263(20):9640-5.
1988: Crisanti A; Müller H M; Hilbich C; Sinigaglia F; Matile H; McKay M; Scaife J; Beyreuther K; Bujard H
Epitopes recognized by human T cells map within the conserved part of the GP190 of P. falciparum.
Science (New York, N.Y.) 1988;240(4857):1324-6.
1988: Shivers B D; Hilbich C; Multhaup G; Salbaum M; Beyreuther K; Seeburg P H
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.
The EMBO journal 1988;7(5):1365-70.
1988: Surek B; Pillay B; Rdest U; Beyreuther K; Goebel W
Evidence for two different gas vesicle proteins and genes in Halobacterium halobium.
Journal of bacteriology 1988;170(4):1746-51.
1988: Dyrks T; Weidemann A; Multhaup G; Salbaum J M; Lemaire H G; Kang J; Müller-Hill B; Masters C L; Beyreuther K
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.
The EMBO journal 1988;7(4):949-57.
1988: Hope J; Multhaup G; Reekie L J; Kimberlin R H; Beyreuther K
Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie.
European journal of biochemistry / FEBS 1988;172(2):271-7.
1988: Masters C L; Beyreuther K
The blood-brain barrier in Alzheimer's disease and normal aging.
Neurobiology of aging 1988;9(1):43-4.
1988: Herrler G; Multhaup G; Beyreuther K; Klenk H D
Serine 71 of the glycoprotein HEF is located at the active site of the acetylesterase of influenza C virus.
Archives of virology 1988;102(3-4):269-74.
1988: Masters C L; Beyreuther K
Neuropathology of unconventional virus infections: molecular pathology of spongiform change and amyloid plaque deposition.
Ciba Foundation symposium 1988;135():24-36.
1988: Grenningloh G; Rienitz A; Schmitt B; Methfessel C; Zensen M; Beyreuther K; Gundelfinger E D; Betz H
Molecular cloning of the antagonist-binding subunit of the glycine receptor.
Journal of receptor research 1988;8(1-4):183-93.
1987: Blanchard D; Dahr W; Beyreuther K; Moulds J; Cartron J P
Hybrid glycophorins from human erythrocyte membranes. Isolation and complete structural analysis of the novel sialoglycoprotein from St(a+) red cells.
European journal of biochemistry / FEBS 1987;167(2):361-6.
1987: Schmitt E; Fassbender B; Beyreuther K; Spaeth E; Schwarzkopf R; Rüde E
Characterization of a T cell-derived lymphokine that acts synergistically with IL 3 on the growth of murine mast cells and is identical with IL 4.
Immunobiology 1987;174(4-5):406-19.
1987: Dahr W; Beyreuther K; Moulds J; Unger P
Hybrid glycophorins from human erythrocyte membranes. I. Isolation and complete structural analysis of the hybrid sialoglycoprotein from Dantu-positive red cells of the N.E. variety.
European journal of biochemistry / FEBS 1987;166(1):31-6.
1987: Grenningloh G; Rienitz A; Schmitt B; Methfessel C; Zensen M; Beyreuther K; Gundelfinger E D; Betz H
The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors.
Nature 1987;328(6127):215-20.
1987: Dahr W; Beyreuther K; Moulds J J
Structural analysis of the major human erythrocyte membrane sialoglycoprotein from Miltenberger class VII cells.
European journal of biochemistry / FEBS 1987;166(1):27-30.
1987: Blanchard D; Dahr W; Hummel M; Latron F; Beyreuther K; Cartron J P
Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis.
The Journal of biological chemistry 1987;262(12):5808-11.
1987: Guiroy D C; Miyazaki M; Multhaup G; Fischer P; Garruto R M; Beyreuther K; Masters C L; Simms G; Gibbs C J; Gajdusek D C
Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(7):2073-7.
1987: Kang J; Lemaire H G; Unterbeck A; Salbaum J M; Masters C L; Grzeschik K H; Multhaup G; Beyreuther K; Müller-Hill B
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
Nature 1987;325(6106):733-6.
1987: Pohlner J; Halter R; Beyreuther K; Meyer T F
Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease.
Nature 1987;325(6103):458-62.
1987: Masters C L; Beyreuther K
Neuronal origin of cerebral amyloidogenic proteins: their role in Alzheimer's disease and unconventional virus diseases of the nervous system.
Ciba Foundation symposium 1987;126():49-64.
1986: Masters C L; Beyreuther K
The structure of amyloid filaments in Alzheimer's disease and the unconventional virus infections of the nervous system.
Psychological medicine 1986;16(4):735-7.
1986: Dahr W; Wilkinson S; Issitt P D; Beyreuther K; Hummel M; Morel P
High frequency antigens of human erythrocyte membrane sialoglycoproteins, III. Studies on the EnaFR, Wrb and Wra antigens.
Biological chemistry Hoppe-Seyler 1986;367(10):1033-45.
1986: Deutscher J; Pevec B; Beyreuther K; Kiltz H H; Hengstenberg W
Streptococcal phosphoenolpyruvate-sugar phosphotransferase system: amino acid sequence and site of ATP-dependent phosphorylation of HPr.
Biochemistry 1986;25(21):6543-51.
1986: Hope J; Morton L J; Farquhar C F; Multhaup G; Beyreuther K; Kimberlin R H
The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP).
The EMBO journal 1986;5(10):2591-7.
1986: Riva S; Morandi C; Tsoulfas P; Pandolfo M; Biamonti G; Merrill B; Williams K R; Multhaup G; Beyreuther K; Werr H
Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1.
The EMBO journal 1986;5(9):2267-73.
1986: Schulze-Gahmen U; Klenk H D; Beyreuther K
Immunogenicity of loop-structured short synthetic peptides mimicking the antigenic site A of influenza virus hemagglutinin.
European journal of biochemistry / FEBS 1986;159(2):283-9.
1985: Dahr W; Beyreuther K
A revision of the N-terminal structure of sialoglycoprotein D (glycophorin C) from human erythrocyte membranes.
Biological chemistry Hoppe-Seyler 1985;366(11):1067-70.
1985: Masters C L; Multhaup G; Simms G; Pottgiesser J; Martins R N; Beyreuther K
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.
The EMBO journal 1985;4(11):2757-63.
1985: Mannhaupt G; Beyreuther K; Michaelis G
Cytochrome b, the var 1 protein, and subunits I and III of cytochrome c oxidase are synthesized without transient presequences in Saccharomyces cerevisiae.
European journal of biochemistry / FEBS 1985;150(3):435-9.
1985: Schulze-Gahmen U; Prinz H; Glatter U; Beyreuther K
Towards assignment of secondary structures by anti-peptide antibodies. Specificity of the immune response to a beta-turn.
The EMBO journal 1985;4(7):1731-7.
1985: Masters C L; Simms G; Weinman N A; Multhaup G; McDonald B L; Beyreuther K
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(12):4245-9.
1985: Multhaup G; Diringer H; Hilmert H; Prinz H; Heukeshoven J; Beyreuther K
The protein component of scrapie-associated fibrils is a glycosylated low molecular weight protein.
The EMBO journal 1985;4(6):1495-501.
1985: Radbruch A; Zaiss S; Kappen C; Brüggemann M; Beyreuther K; Rajewsky K
Drastic change in idiotypic but not antigen-binding specificity of an antibody by a single amino-acid substitution.
Nature 1985;315(6019):506-8.
1985: Stüber K; Deutscher J; Sobek H M; Hengstenberg W; Beyreuther K
Amino acid sequence of the amphiphilic phosphocarrier protein factor IIILac of the lactose-specific phosphotransferase system of Staphylococcus.
Biochemistry 1985;24(5):1164-8.
1985: Bieseler B; Prinz H; Beyreuther K
Topological studies of lactose permease of Escherichia coli by protein sequence analysis.
Annals of the New York Academy of Sciences 1985;456():309-25.
1984: Dahr W; Kordowicz M; Judd W J; Moulds J; Beyreuther K; Krüger J
Structural analysis of the Ss sialoglycoprotein specific for Henshaw blood group from human erythrocyte membranes.
European journal of biochemistry / FEBS 1984;141(1):51-5.
1984: Dildrop R; Bovens J; Siekevitz M; Beyreuther K; Rajewsky K
A V region determinant (idiotope) expressed at high frequency in B lymphocytes is encoded by a large set of antibody structural genes.
The EMBO journal 1984;3(3):517-23.
1984: Dahr W; Newman R A; Contreras M; Kordowicz M; Teesdale P; Beyreuther K; Krüger J
Structures of Miltenberger class I and II specific major human erythrocyte membrane sialoglycoproteins.
European journal of biochemistry / FEBS 1984;138(2):259-65.
1983: Zaiss S; Beyreuther K
Myeloma class switch variant X63.2aRI-16 secretes IgG2a and IgG1 with identical VDJ sequence.
European journal of immunology 1983;13(6):508-13.
1983: Buck F; Hahn K D; Zemann W; Rüterjans H; Sadler J R; Beyreuther K; Kaptein R; Scheek R; Hull W E
NMR study of the interaction between the lac repressor and the lac operator.
European journal of biochemistry / FEBS 1983;132(2):321-7.
1983: Scheek R M; Zuiderweg E R; Klappe K J; van Boom J H; Kaptein R; Rüterjans H; Beyreuther K
lac Repressor headpiece binds specifically to half of the lac operator: a proton nuclear magnetic resonance study.
Biochemistry 1983;22(1):228-35.
1983: Pratje E; Mannhaupt G; Michaelis G; Beyreuther K
A nuclear mutation prevents processing of a mitochondrially encoded membrane protein in Saccharomyces cerevisiae.
The EMBO journal 1983;2(7):1049-54.
1983: Beyreuther K; Bovens J; Brüggemann M; Dildrop R; Kelsoe G; Krawinkel U; Müller C; Nishikawa S; Radbruch A; Reth M
Idiotypic determinants used in the analysis of antibody diversification and as regulatory targets.
Annals of the New York Academy of Sciences 1983;418():121-9.
1982: Deutscher J; Beyreuther K; Sobek H M; Stüber K; Hengstenberg W
Phosphoenolpyruvate-dependent phosphotransferase system of Staphylococcus aureus: factor IIIlac, a trimeric phospho-carrier protein that also acts as a phase transfer catalyst.
Biochemistry 1982;21(20):4867-73.
1982: Dahr W; Beyreuther K; Kordowicz M; Krüger J
N-terminal amino acid sequence of sialoglycoprotein D (glycophorin C) from human erythrocyte membranes.
European journal of biochemistry / FEBS 1982;125(1):57-62.
1982: Wright J K; Schwarz H; Straub E; Overath P; Bieseler B; Beyreuther K
Lactose carrier protein of Escherichia coli. Reconstitution of galactoside binding and countertransport.
European journal of biochemistry / FEBS 1982;124(3):545-52.
1982: Beyreuther K; Berthold-Schmidt V; Geider K
Biological activity and a partial amino-acid sequence of Escherichia coli DNA-binding protein I isolated from overproducing cells.
European journal of biochemistry / FEBS 1982;123(2):415-20.
1982: Dildrop R; Brüggemann M; Radbruch A; Rajewsky K; Beyreuther K
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.
The EMBO journal 1982;1(5):635-40.
1981: Zuiderweg E R; Scheek R M; Veeneman G; van Boom J H; Kaptein R; Rüterjans H; Beyreuther K
1H NMR studies of lac-operator DNA fragments.
Nucleic acids research 1981;9(23):6553-69.
1981: Hinz H J; Cossmann M; Beyreuther K
lac Repressor headpiece constitutes a reversibly unfolding domain.
FEBS letters 1981;129(2):246-8.
1981: Dildrop R; Beyreuther K
C-terminal sequence of the secreted form of mouse IgD heavy chain.
Nature 1981;292(5818):61-3.
1981: Dahr W; Kordowicz M; Beyreuther K; Krüger J
The amino acid sequence of the Mc-specific major red cell membrane sialoglycoprotein--an intermediate of the blood group M- and N-active molecules.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1981;362(3):363-6.
1981: Dahr W; Beyreuther K; Gallasch E; Krüger J; Morel P
Amino acid sequence of the blood group Mg-specific major human erythrocyte membrane sialoglycoprotein.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1981;362(1):81-5.
1981: Trinks K; Habermann P; Beyreuther K; Starlinger P; Ehring R
An IS4-encoded protein is synthesized in minicells.
Molecular & general genetics : MGG 1981;182(2):183-8.
1980: Beyreuther K; Bieseler B; Ehring R; Griesser H W; Mieschendahl M; Müller-Hill B; Triesch I
Investigation of structure and function of lactose permease of Escherichia coli.
Biochemical Society transactions 1980;8(6):675-6.
1980: Buck F; Rüterjans H; Kaptein R; Beyreuther K
Photochemically induced dynamic nuclear polarization investigation of complex formation of the NH2-terminal DNA-binding domain of lac repressor with poly[d(AT)].
Proceedings of the National Academy of Sciences of the United States of America 1980;77(9):5145-8.
1980: Ehring R; Beyreuther K; Wright J K; Overath P
In vitro and in vivo products of E. coli lactose permease gene are identical.
Nature 1980;283(5747):537-40.
1980: Dahr W; Gielen W; Beyreuther K; Krüger J
Structure of the Ss blood group antigens. I. Isolation of Ss-active glycopeptides and differentiation of the antigens by modification of methionine.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1980;361(2):145-52.
1980: Meyer T F; Beyreuther K; Geider K
Recognition of two initiation codons for the synthesis of phage fd gene 2 protein.
Molecular & general genetics : MGG 1980;180(3):489-94.
1980: Dahr W; Beyreuther K; Steinbach H; Gielen W; Krüger J
Structure of the Ss blood group antigens, II: a methionine/threonine polymorphism within the N-terminal sequence of the Ss glycoprotein.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1980;361(6):895-906.
1979: Schlotmann M; Beyreuther K
Degradation of the DNA-binding domain of wild-type and i-d lac repressors in Escherichia coli.
European journal of biochemistry / FEBS 1979;95(1):39-49.
1978: Buck F; Rüterjans H; Beyreuther K
1H NMR study of the lactose repressor from Escherichia coli.
FEBS letters 1978;96(2):335-8.
1978: Beyreuther K; Böhmer H; Dimroth P
Amino-acid sequence of citrate-lyase acyl-carrier protein from Klebsiella aerogenes.
European journal of biochemistry / FEBS 1978;87(1):101-10.
1977: Beyreuther K; Raufuss H; Schrecker O; Hengstenberg W
The phosphoenolpyruvate-dependent phosphotransferase system of Staphylococcus aureus. 1. Amino-acid sequence of the phosphocarrier protein HPr.
European journal of biochemistry / FEBS 1977;75(1):275-86.
1976: Beyreuther K; Gronenborn B
N-terminal sequence of phage lambda repressor.
Molecular & general genetics : MGG 1976;147(1):115-7.
1975: Beyreuther K; Adler K; Fanning E; Murray C; Klemm A; Geisler N
Amino-acid sequence of lac repressor from Escherichia coli. Isolation, sequence analysis and sequence assembly of tryptic peptides and cyanogen-bromide fragments.
European journal of biochemistry / FEBS 1975;59(2):491-509.
1975: Horst J; Kluge F; Beyreuther K; Gerok W
Gene transfer to human cells: transducing phage lambda plac gene expression in GMI-gangliosidosis fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(9):3531-5.
1973: Beyreuther K; Adler K; Geisler N; Klemm A
The amino-acid sequence of lac repressor.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(12):3576-80.
1973: Rao D R; Beyreuther K; Jaenicke L
A comparative study of pig and sheep-brain glutamine synthetases: tryptic peptides and thiol groups.
European journal of biochemistry / FEBS 1973;35(3):582-92.
1972: Adler K; Beyreuther K; Fanning E; Geisler N; Gronenborn B; Klemm A; Müller-Hill B; Pfahl M; Schmitz A
How lac repressor binds to DNA.
Nature 1972;237(5354):322-7.
1972: Beyreuther K; Klemm A; Müller-Hill B
[How does the lac repressor recognize the lac operator?]
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1972;353(5):693-4.
1969: Asbeck F; Beyreuther K; Köhler H; von Wettstein G; Braunitzer G
[Virus proteins. IV. Constitution of the coat protein of the fd phage]
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1969;350(9):1047-66.
1968: Braunitzer G; Beyreuther K; Fujiki H; Schrank B
[Tetrafluorosuccinic anhydride, a new reagent for the specific and reversible masking of amino groups in proteins]
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1968;349(2):265.
1967: Braunitzer G; Asbeck F; Beyreuther K; Kohler H; von Wettstein G
[The constitution of the coat protein of bacteriophage fd]
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1967;348(12):1689-90.
1967: Braunitzer G; Asbeck F; Beyreuther K; Köhler H; von Wettstein G
[Constitution of the coat protein of bacteriophage fd]
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1967;348(6):725-6.

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