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Klaus Rajewsky

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TOP 3
Klaus Rajewsky
Years in Cologne.
Marta Derecka; Agnieszka Gornicka; Thurl E Harris; Susanna R Keller; Sergei B Koralov; Tomasz Kordula; Joanna Cichy; Colleen Croniger; Andrew J McAinch; Magdalena Morgan; Paul E O'brien; Dennis Otero; Sandra Pellegrini; Valeria Poli; Vidisha Raje; Klaus Rajewsky; Aaron P Russell; Patrick Seale; Kazuya Shimoda; Jennifer Sisler; Birgit Strobl; Karol Szczepanek; Qifang Zhang; Andrew C Larner
Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.
Dinis Calado; Ignacio Moreno de Alborán; Susana A Godinho; Martin Janz; Karl Köchert; Alex Pellerin; Scott Rodig; Yoshiteru Sasaki; Barry P Sleckman; Klaus Rajewsky
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.

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All Publications

2013: Klaus Rajewsky
Years in Cologne.
Annual review of immunology 2013;31():1-29.
2012: Marta Derecka; Agnieszka Gornicka; Thurl E Harris; Susanna R Keller; Sergei B Koralov; Tomasz Kordula; Joanna Cichy; Colleen Croniger; Andrew J McAinch; Magdalena Morgan; Paul E O'brien; Dennis Otero; Sandra Pellegrini; Valeria Poli; Vidisha Raje; Klaus Rajewsky; Aaron P Russell; Patrick Seale; Kazuya Shimoda; Jennifer Sisler; Birgit Strobl; Karol Szczepanek; Qifang Zhang; Andrew C Larner
Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.
Cell metabolism 2012;16(6):814-24.
2012: Dinis Calado; Ignacio Moreno de Alborán; Susana A Godinho; Martin Janz; Karl Köchert; Alex Pellerin; Scott Rodig; Yoshiteru Sasaki; Barry P Sleckman; Klaus Rajewsky
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Nature immunology 2012;13(11):1092-100.
2012: Sandrine Sander; Klaus Rajewsky
Burkitt lymphomagenesis linked to MYC plus PI3K in germinal center B cells.
Oncotarget 2012;3(10):1066-7.
2012: Sandrine Sander; Reiner Siebert; Lakshmi Srinivasan; Stephan Stilgenbauer; Baochun Zhang; Lars Bullinger; Dinis Calado; Karlheinz Holzmann; Karl Köchert; Scott Rodig; Maciej Rosolowski; Klaus Rajewsky
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.
Cancer cell 2012;22(2):167-79.
2012: Baochun Zhang; Scott J Rodig; Matthew Vanneman; Zhe Wang; Tomoharu Yasuda; Stefano Casola; Tirtha Chakraborty; Shane E Cotter; Treeve Currie; Emmanuel Derudder; Glenn Dranoff; Gordon J Freeman; Cornelia Hömig-Hölzel; Shohei Koyama; Sven Kracker; Jeffery L Kutok; Shuang Li; Klaus Rajewsky
Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model.
Cell 2012;148(4):739-51.
2011: Heide Christine Patterson; Joel M Henderson; Manfred Kraus; Kevin L Otipoby; Jane Seagal; Aliakbar Shahsafaei; To-Ha Thai; Donghai Wang; Klaus Rajewsky
Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):2853-8.
2011: Myunggon Ko; Sergei B Koralov; Edward D Lamperti; Klaus Rajewsky; Jungeun An; Hozefa S Bandukwala; Ryan Hastie; Elizabeth C Thompson; Angeliki Tsangaratou; Anjana Rao
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(35):14566-71.
2011: Michael Green; Stefano Monti; Riccardo Dalla-Favera; Laura Pasqualucci; Nicole C Walsh; Marc Schmidt-Supprian; Jeffery L Kutok; Scott Rodig; Donna S Neuberg; Klaus Rajewsky; Todd R Golub; Frederick W Alt; Margaret A Shipp; John P Manis
Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(7):2873-8.
2011: Ramy Arnaout; Patrick Cahill; Tracey Honan; William Lee; Chad Nusbaum; Klaus Rajewsky; Todd Sparrow; Michael Weiand; Sergei B Koralov
High-resolution description of antibody heavy-chain repertoires in humans.
PloS one 2011;6(8):e22365.
2010: Dinis Calado; Baochun Zhang; Lakshmi Srinivasan; Yoshiteru Sasaki; Jane Seagal; Christine Unitt; Scott Rodig; Jeffery Kutok; Alexander Tarakhovsky; Marc Schmidt-Supprian; Klaus Rajewsky
Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma.
Cancer cell 2010;18(6):580-9.
2010: Jonathan Mandelbaum; Govind Bhagat; Hongyan Tang; Tongwei Mo; Manisha Brahmachary; Qiong Shen; Amy Chadburn; Klaus Rajewsky; Alexander Tarakhovsky; Laura Pasqualucci; Riccardo Dalla-Favera
BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma.
Cancer cell 2010;18(6):568-79.
2010: Srimoyee Ghosh; Sergei B Koralov; Irena Stevanovic; Mark S Sundrud; Yoshiteru Sasaki; Klaus Rajewsky; Anjana Rao; Martin R Müller
Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(34):15169-74.
2009: Lakshmi Srinivasan; Yoshiteru Sasaki; Dinis Calado; Baochun Zhang; Ji Hye Paik; Ronald A DePinho; Jeffrey L Kutok; John F Kearney; Kevin L Otipoby; Klaus Rajewsky
PI3 kinase signals BCR-dependent mature B cell survival.
Cell 2009;139(3):573-86.
2009: Emmanuel Derudder; Emily J Cadera; J Christoph Vahl; Jing Wang; Casey J Fox; Shan Zha; Geert van Loo; Manolis Pasparakis; Mark S Schlissel; Marc Schmidt-Supprian; Klaus Rajewsky
Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.
Nature immunology 2009;10(6):647-54.
2009: Martin R Müller; Yoshiteru Sasaki; Irena Stevanovic; Edward D Lamperti; Srimoyee Ghosh; Sonia Sharma; Curtis Gelinas; Derrick J Rossi; Matthew E Pipkin; Klaus Rajewsky; Patrick G Hogan; Anjana Rao
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7034-9.
2009: Li-Fan Lu; To-Ha Thai; Dinis Calado; Ashutosh Chaudhry; Masato Kubo; Kentaro Tanaka; Gabriel B Loeb; Hana Lee; Akihiko Yoshimura; Klaus Rajewsky; Alexander Y Rudensky
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein.
Immunity 2009;30(1):80-91.
2009: Changchun Xiao; Klaus Rajewsky
MicroRNA control in the immune system: basic principles.
Cell 2009;136(1):26-36.
2008: Michael Zemlin; Robert L Schelonka; Gregory Charles Ippolito; Cosima Zemlin; Yingxin Zhuang; G Larry Gartland; Lars Nitschke; Jukka Pelkonen; Klaus Rajewsky; Harry Schroeder
Regulation of repertoire development through genetic control of DH reading frame preference.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8416-24.
2008: Robert L Schelonka; Michael Zemlin; Ryoki Kobayashi; Gregory Charles Ippolito; Yingxin Zhuang; G Larry Gartland; Alexander Szalai; Kohtaro Fujihashi; Klaus Rajewsky; Harry Schroeder
Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8409-15.
2008: Zhenyue Hao; Gordon S Duncan; Jane Seagal; Yu-Wen Su; Claire Hong; Jillian Haight; Nien-Jung Chen; Andrew Elia; Andrew Wakeham; Wanda Y Li; Jennifer Liepa; Geoffrey A Wood; Stefano Casola; Klaus Rajewsky; Tak W Mak
Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.
Immunity 2008;29(4):615-27.
2008: Yousang Gwack; Sonal Srikanth; Masatsugu Oh-hora; Patrick G Hogan; Edward D Lamperti; Megumi Yamashita; Curtis Gelinas; Daniel S Neems; Yoshiteru Sasaki; Stefan Feske; Murali Prakriya; Klaus Rajewsky; Anjana Rao
Hair loss and defective T- and B-cell function in mice lacking ORAI1.
Molecular and cellular biology 2008;28(17):5209-22.
2008: Kevin L Otipoby; Yoshiteru Sasaki; Marc Schmidt-Supprian; Alina Patke; Ralph Gareus; Manolis Pasparakis; Alexander Tarakhovsky; Klaus Rajewsky
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12435-8.
2008: Yoshiteru Sasaki; Dinis Calado; Emmanuel Derudder; Baochun Zhang; Yuri Shimizu; Fabienne Mackay; Shin-ichi Nishikawa; Klaus Rajewsky; Marc Schmidt-Supprian
NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10883-8.
2008: Christine Bourgeois; Zhenyue Hao; Klaus Rajewsky; Alexandre J Potocnik; Brigitta Stockinger
Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8691-6.
2008: Cornelia Hömig-Hölzel; Caroline Hojer; Julia Rastelli; Stefano Casola; Lothar Strobl; Werner Muller; Leticia Quintanilla-Martinez; Andreas Gewies; Jürgen Ruland; Klaus Rajewsky; Ursula Zimber-Strobl
Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.
The Journal of experimental medicine 2008;205(6):1317-29.
2008: Yair Dorsett; Kevin M McBride; Mila Jankovic; Anna Gazumyan; To-Ha Thai; Davide F Robbiani; Michela Di Virgilio; Bernardo Reina San-Martin; Gordon Heidkamp; Tanja A Schwickert; Thomas Eisenreich; Klaus Rajewsky; Michel C Nussenzweig
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation.
Immunity 2008;28(5):630-8.
2008: Klaus Rajewsky; Harald von Boehmer
Lymphocyte development: overview.
Current opinion in immunology 2008;20(2):127-30.
2008: Changchun Xiao; Lakshmi Srinivasan; Dinis Calado; Heide Christine Patterson; Baochun Zhang; Jing Wang; Joel M Henderson; Jeffery L Kutok; Klaus Rajewsky
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes.
Nature immunology 2008;9(4):405-14.
2008: Sergei B Koralov; Stefan A Muljo; Gunther R Galler; Azra Krek; Tirtha Chakraborty; Chrysi Kanellopoulou; Kari Jensen; Bradley S Cobb; Matthias Merkenschlager; Nikolaus Rajewsky; Klaus Rajewsky
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage.
Cell 2008;132(5):860-74.
2008: Andrea Mesaros; Sergei B Koralov; Eva Rother; F Thomas Wunderlich; Marianne B Ernst; Gregory S Barsh; Klaus Rajewsky; Jens C Brüning
Activation of Stat3 signaling in AgRP neurons promotes locomotor activity.
Cell metabolism 2008;7(3):236-48.
2008: Julia Rastelli; Cornelia Hömig-Hölzel; Jane Seagal; Werner Muller; Andrea C Hermann; Klaus Rajewsky; Ursula Zimber-Strobl
LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1.
Blood 2008;111(3):1448-55.
2007: Efrat Edry; Sergei B Koralov; Klaus Rajewsky; Doron Melamed
Spontaneous class switch recombination in B cell lymphopoiesis generates aberrant switch junctions and is increased after VDJ rearrangement.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6555-60.
2007: Klaus Rajewsky
From a dream to reality.
European journal of immunology 2007;37 Suppl 1():S134-7.
2007: Changchun Xiao; Dinis Calado; Gunther Galler; To-Ha Thai; Heide Christine Patterson; Jing Wang; Nikolaus Rajewsky; Timothy P Bender; Klaus Rajewsky
MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb.
Cell 2007;131(1):146-59.
2007: Marc Schmidt-Supprian; F Thomas Wunderlich; Klaus Rajewsky
Excision of the Frt-flanked neo (R) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination.
Transgenic research 2007;16(5):657-60.
2007: Lily I Pao; Kong-Peng Lam; Joel M Henderson; Jeffery L Kutok; Marat Alimzhanov; Lars Nitschke; Matthew L Thomas; Benjamin G Neel; Klaus Rajewsky
B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.
Immunity 2007;27(1):35-48.
2007: Marc Schmidt-Supprian; Klaus Rajewsky
Vagaries of conditional gene targeting.
Nature immunology 2007;8(7):665-8.
2007: Bernhard Greve; Robert Weissert; Nada Hamdi; Estelle Bettelli; Raymond A Sobel; Anthony J Coyle; Vijay K Kuchroo; Klaus Rajewsky; Marc Schmidt-Supprian
I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):179-85.
2007: Shira Fraenkel; Raul Mostoslavsky; Tatiana I Novobrantseva; Roberta Pelanda; Jayanta Chaudhuri; Gloria Esposito; Steffen Jung; Frederick W Alt; Klaus Rajewsky; Howard Cedar; Yehudit Bergman
Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus.
Nature immunology 2007;8(7):715-22.
2007: Huifei Liu; Marc Schmidt-Supprian; Yujiang Shi; Elias Hobeika; Natasha Barteneva; Hassan Jumaa; Roberta Pelanda; Michael Reth; Jane Skok; Klaus Rajewsky; Yang Shi
Yin Yang 1 is a critical regulator of B-cell development.
Genes & development 2007;21(10):1179-89.
2007: To-Ha Thai; Dinis Calado; Stefano Casola; K Mark Ansel; Changchun Xiao; Yingzi Xue; Andrew Murphy; David Frendewey; David M Valenzuela; Jeffery L Kutok; Marc Schmidt-Supprian; Nikolaus Rajewsky; George D Yancopoulos; Anjana Rao; Klaus Rajewsky
Regulation of the germinal center response by microRNA-155.
Science (New York, N.Y.) 2007;316(5824):604-8.
2007: Ari Waisman; Manfred Kraus; Jane Seagal; Snigdha Ghosh; Doron Melamed; Jian Song; Yoshiteru Sasaki; Sabine Classen; Claudia Lutz; Frank Brombacher; Lars Nitschke; Klaus Rajewsky
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta.
The Journal of experimental medicine 2007;204(4):747-58.
2007: Yoshiteru Sasaki; Marc Schmidt-Supprian; Emmanuel Derudder; Klaus Rajewsky
Role of NFkappaB signaling in normal and malignant B cell development.
Advances in experimental medicine and biology 2007;596():149-54.
2006: J Rodrigo Mora; Makoto Iwata; Bertus Eksteen; Si-Young Song; Tobias Junt; Balimkiz Senman; Kevin L Otipoby; Aya Yokota; Hajime Takeuchi; Paola Ricciardi-Castagnoli; Klaus Rajewsky; David H Adams; Ulrich H von Andrian
Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells.
Science (New York, N.Y.) 2006;314(5802):1157-60.
2006: Fiona O Baxter; Paul J Came; Kathrine Abell; Blandine Kedjouar; Marion Huth; Klaus Rajewsky; Manolis Pasparakis; Christine J Watson
IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells.
Development (Cambridge, England) 2006;133(17):3485-94.
2006: Sergei B Koralov; Tatiana I Novobrantseva; Jessica Königsmann; Andreas Ehlich; Klaus Rajewsky
Antibody repertoires generated by VH replacement and direct VH to JH joining.
Immunity 2006;25(1):43-53.
2006: Ulf Klein; Stefano Casola; Giorgio Cattoretti; Qiong Shen; Mariel Lia; Tongwei Mo; Thomas Ludwig; Klaus Rajewsky; Riccardo Dalla-Favera
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.
Nature immunology 2006;7(7):773-82.
2006: Dominik Schenten; Angela Egert; Manolis Pasparakis; Klaus Rajewsky
M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice.
Blood 2006;107(12):4849-56.
2006: Yoshiteru Sasaki; Emmanuel Derudder; Elias Hobeika; Roberta Pelanda; Michael Reth; Klaus Rajewsky; Marc Schmidt-Supprian
Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation.
Immunity 2006;24(6):729-39.
2006: Stefano Casola; Giorgio Cattoretti; Nathalie Uyttersprot; Sergei B Koralov; Jane Seagal; Jane Segal; Zhenyue Hao; Ari Waisman; Angela Egert; Dvora Ghitza; Klaus Rajewsky
Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(19):7396-401.
2006: Arianna Nenci; Marion Huth; Alfred Funteh; Marc Schmidt-Supprian; Wilhelm Bloch; Daniel Metzger; Pierre Chambon; Klaus Rajewsky; Thomas Krieg; Ingo Haase; Manolis Pasparakis
Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.
Human molecular genetics 2006;15(4):531-42.
2006: Stefano Casola; Klaus Rajewsky
B cell recruitment and selection in mouse GALT germinal centers.
Current topics in microbiology and immunology 2006;308():155-71.
2006: Panayiotis Victoratos; Jacques Lagnel; sotiria tzima; Marat B Alimzhanov; Klaus Rajewsky; Manolis Pasparakis; george kollias
FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses.
Immunity 2006;24(1):65-77.
2005: Stefan A Muljo; K Mark Ansel; Chrysi Kanellopoulou; David M Livingston; Anjana Rao; Klaus Rajewsky
Aberrant T cell differentiation in the absence of Dicer.
The Journal of experimental medicine 2005;202(2):261-9.
2005: Philipp Oberdoerffer; Chrysi Kanellopoulou; Vigo Heissmeyer; Corinna Paeper; Christine Borowski; Ioannis Aifantis; Anjana Rao; Klaus Rajewsky
Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages.
Molecular and cellular biology 2005;25(10):3896-905.
2005: Tom Luedde; Ulrike Assmus; Torsten Wüstefeld; Andreas Meyer zu Vilsendorf; Tania Roskams; Marc Schmidt-Supprian; Klaus Rajewsky; David A Brenner; Michael P Manns; Manolis Pasparakis; Christian Trautwein
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.
The Journal of clinical investigation 2005;115(4):849-59.
2005: Lina E Tze; Brian R Schram; Kong-Peng Lam; Kristin A Hogquist; Keli L Hippen; Jiabin Liu; Susan A Shinton; Kevin L Otipoby; Peter Rodine; Amanda L Vegoe; Manfred Kraus; Richard R Hardy; Mark S Schlissel; Klaus Rajewsky; timothy wayne behrens
Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.
PLoS biology 2005;3(3):e82.
2005: Malay Mandal; Christine Borowski; Teresa Palomero; Adolfo Ferrando; Philipp Oberdoerffer; Fanyong Meng; Antonio Ruiz-Vela; Maria Ciofani; Juan Carlos Zuniga-Pflucker; Isabella Screpanti; A Thomas Look; Stanley J Korsmeyer; Klaus Rajewsky; Harald von Boehmer; Ioannis Aifantis
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.
The Journal of experimental medicine 2005;201(4):603-14.
2005: Chrysi Kanellopoulou; Stefan A Muljo; Andrew L Kung; Shridar Ganesan; Ronny Drapkin; Thomas Jenuwein; David M Livingston; Klaus Rajewsky
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing.
Genes & development 2005;19(4):489-501.
2005: Sergei B Koralov; Tatiana I Novobrantseva; Konrad Hochedlinger; Rudolf Jaenisch; Klaus Rajewsky
Direct in vivo VH to JH rearrangement violating the 12/23 rule.
The Journal of experimental medicine 2005;201(3):341-8.
2005: Silvia Monticelli; K Mark Ansel; Changchun Xiao; Nicholas D Socci; Anna M Krichevsky; To-Ha Thai; Nikolaus Rajewsky; Debora S Marks; Chris Sander; Klaus Rajewsky; Anjana Rao; Kenneth S Kosik
MicroRNA profiling of the murine hematopoietic system.
Genome biology 2005;6(8):R71.
2004: Axel Roers; Lisa Siewe; Elke Strittmatter; Martina Deckert; Dirk Schlüter; Werner Stenzel; Achim D Gruber; Thomas Krieg; Klaus Rajewsky; Werner Muller
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation.
The Journal of experimental medicine 2004;200(10):1289-97.
2004: Yoshiteru Sasaki; Stefano Casola; Jeffery L Kutok; Klaus Rajewsky; Marc Schmidt-Supprian
TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2245-52.
2004: Marc Schmidt-Supprian; Jane Tian; Hongbin Ji; Cox Terhorst; Atul K Bhan; Ethan P Grant; Manolis Pasparakis; Stefano Casola; Anthony J Coyle; Klaus Rajewsky
I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1612-9.
2004: Manfred Kraus; Marat B Alimzhanov; Nikolaus Rajewsky; Klaus Rajewsky
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer.
Cell 2004;117(6):787-800.
2004: Marc Schmidt-Supprian; Jane Tian; Ethan P Grant; Manolis Pasparakis; Rene Maehr; Huib Ovaa; Hidde L Ploegh; Anthony J Coyle; Klaus Rajewsky
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4566-71.
2004: Amy Reichlin; Anna Gazumyan; Hitoshi Nagaoka; Kathrin H Kirsch; Manfred Kraus; Klaus Rajewsky; Michel C Nussenzweig
A B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells.
The Journal of experimental medicine 2004;199(6):855-65.
2004: Stefano Casola; Kevin L Otipoby; Marat Alimzhanov; Sibille Humme; Nathalie Uyttersprot; Jeffery L Kutok; Michael C Carroll; Klaus Rajewsky
B cell receptor signal strength determines B cell fate.
Nature immunology 2004;5(3):317-27.
2004: Christian Skulina; Stephan Schmidt; Klaus Dornmair; Holger Babbe; Axel Roers; Klaus Rajewsky; Hartmut Wekerle; Reinhard Hohlfeld; Norbert Goebels
Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2428-33.
2004: Mathias Röhl; Manolis Pasparakis; Stephanie Baudler; Julia Baumgartl; Dinesh Gautam; Marion Huth; Rossana De Lorenzi; Wilhelm Krone; Klaus Rajewsky; Jens C Brüning
Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance.
The Journal of clinical investigation 2004;113(3):474-81.
2003: Philipp Oberdoerffer; Kevin L Otipoby; Mitsuo Maruyama; Klaus Rajewsky
Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71.
Nucleic acids research 2003;31(22):e140.
2003: Edwin Kanters; Manolis Pasparakis; Marion J J Gijbels; Monique N Vergouwe; Iris Partouns-Hendriks; Remond J A Fijneman; Björn E Clausen; Irmgard Förster; Mark M Kockx; Klaus Rajewsky; Georg Kraal; Marten H Hofker; Menno de Winther
Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.
The Journal of clinical investigation 2003;112(8):1176-85.
2003: Marc Schmidt-Supprian; Gilles Courtois; Jane Tian; Anthony J Coyle; Alain Israël; Klaus Rajewsky; Manolis Pasparakis
Mature T cells depend on signaling through the IKK complex.
Immunity 2003;19(3):377-89.
2003: Philipp Oberdoerffer; Tatiana I Novobrantseva; Klaus Rajewsky
Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements.
The Journal of experimental medicine 2003;197(9):1165-72.
2003: Julia Kurth; Martin-Leo Hansmann; Klaus Rajewsky; Ralf Küppers
Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4730-5.
2003: Andreas Bräuninger; Hans-Heinrich Wacker; Klaus Rajewsky; Ralf Küppers; Martin-Leo Hansmann
Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma.
Cancer research 2003;63(7):1644-51.
2003: Neal N Iwakoshi; Ann-Hwee Lee; Prasanth Vallabhajosyula; Kevin L Otipoby; Klaus Rajewsky; Laurie H Glimcher
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.
Nature immunology 2003;4(4):321-9.
2003: Ines Schwering; Andreas Bräuninger; Verena Distler; Julia Jesdinsky; Volker Diehl; Martin-Leo Hansmann; Klaus Rajewsky; Ralf Küppers
Profiling of Hodgkin's lymphoma cell line L1236 and germinal center B cells: identification of Hodgkin's lymphoma-specific genes.
Molecular medicine (Cambridge, Mass.) 2003;9(3-4):85-95.
2003: Jost Seibler; Branko Zevnik; Birgit Küter-Luks; Susanne Andreas; Heidrun Kern; Thomas Hennek; Anja Rode; Cornelia Heimann; Nicole Faust; Gunther Kauselmann; Michael Schoor; Rudolf Jaenisch; Klaus Rajewsky; Ralf Kühn; Frieder Schwenk
Rapid generation of inducible mouse mutants.
Nucleic acids research 2003;31(4):e12.
2003: Ines Schwering; Andreas Bräuninger; Ulf Klein; Berit Jungnickel; Marianne Tinguely; Volker Diehl; Martin-Leo Hansmann; Riccardo Dalla-Favera; Klaus Rajewsky; Ralf Küppers
Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.
Blood 2003;101(4):1505-12.
2002: Julia Kurth; Andreas Perniok; Roland Schmitz; Christof Iking-Konert; Nicholas Chiorazzi; Keith M Thompson; Thomas Winkler; Klaus Rajewsky; Ralf Küppers
Lack of deleterious somatic mutations in the CD95 gene of plasmablasts from systemic lupus erythematosus patients and autoantibody-producing cell lines.
European journal of immunology 2002;32(12):3785-92.
2002: Dmitry V Kuprash; Marat B Alimzhanov; Alexei Tumanov; Sergei Grivennikov; Alexander N Shakhov; Ludmila N Drutskaya; Michael W Marino; Regina L Turetskaya; Arthur O. Anderson; Klaus Rajewsky; Klaus Pfeffer; Sergei A Nedospasov
Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice.
Molecular and cellular biology 2002;22(24):8626-34.
2002: Niklas Feldhahn; Ines Schwering; Sanggyu Lee; Maria Wartenberg; Florian Klein; Hui Wang; Guolin Zhou; San Ming Wang; Janet D Rowley; Jürgen Hescheler; Martin Krönke; Klaus Rajewsky; Ralf Küppers; Markus Müschen
Silencing of B cell receptor signals in human naive B cells.
The Journal of experimental medicine 2002;196(10):1291-305.
2002: Dominik Schenten; Valerie L Gerlach; Caixia Guo; Susana Velasco-Miguel; Christa L Hladik; Charles L White; Errol C Friedberg; Klaus Rajewsky; Gloria Esposito
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice.
European journal of immunology 2002;32(11):3152-60.
2002: Manolis Pasparakis; Marc Schmidt-Supprian; Klaus Rajewsky
IkappaB kinase signaling is essential for maintenance of mature B cells.
The Journal of experimental medicine 2002;196(6):743-52.
2002: Manolis Pasparakis; Gilles Courtois; Martin Hafner; Marc Schmidt-Supprian; Arianna Nenci; Atiye Toksoy; Monika Krampert; Matthias Goebeler; Reinhard Gillitzer; Alain Israel; Thomas Krieg; Klaus Rajewsky; Ingo Haase
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2.
Nature 2002;417(6891):861-6.
2002: Thorsten Buch; Frédéric Rieux-Laucat; Irmgard Förster; Klaus Rajewsky
Failure of HY-specific thymocytes to escape negative selection by receptor editing.
Immunity 2002;16(5):707-18.
2002: Michael Peitz; Kurt Pfannkuche; Klaus Rajewsky; Frank Edenhofer
Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4489-94.
2002: Markus Müschen; Klaus Rajewsky; Martin Krönke; Ralf Küppers
The origin of CD95-gene mutations in B-cell lymphoma.
Trends in immunology 2002;23(2):75-80.
2002: Ralf Küppers; Ines Schwering; Andreas Bräuninger; Klaus Rajewsky; Martin-Leo Hansmann
Biology of Hodgkin's lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13 Suppl 1():11-8.
2001: T Goossens; Andreas Bräuninger; Ulf Klein; Ralf Küppers; Klaus Rajewsky
Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation.
European journal of immunology 2001;31(12):3638-48.
2001: Andreas Bräuninger; T Goossens; Klaus Rajewsky; Ralf Küppers
Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human.
European journal of immunology 2001;31(12):3631-7.
2001: Z Hao; Klaus Rajewsky
Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow.
The Journal of experimental medicine 2001;194(8):1151-64.
2001: Andreas Bräuninger; Tilmann Spieker; Klaus Willenbrock; Philippe Gaulard; Hans-Heinrich Wacker; Klaus Rajewsky; Martin-Leo Hansmann; Ralf Küppers
Survival and clonal expansion of mutating "forbidden" (immunoglobulin receptor-deficient) epstein-barr virus-infected b cells in angioimmunoblastic t cell lymphoma.
The Journal of experimental medicine 2001;194(7):927-40.
2001: Manfred Kraus; LI Pao; Amy Reichlin; Y Hu; B Canono; John C Cambier; Michel C Nussenzweig; Klaus Rajewsky
Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail.
The Journal of experimental medicine 2001;194(4):455-69.
2001: M Aranda; C Kanellopoulou; Nicole Christ; Michael Peitz; Klaus Rajewsky; Peter Dröge
Altered directionality in the Cre-LoxP site-specific recombination pathway.
Journal of molecular biology 2001;311(3):453-9.
2001: B Polic; Désirée Kunkel; Alexander Scheffold; Klaus Rajewsky
How alpha beta T cells deal with induced TCR alpha ablation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8744-9.
2001: F Thomas Wunderlich; H Wildner; Klaus Rajewsky; Frank Edenhofer
New variants of inducible Cre recombinase: a novel mutant of Cre-PR fusion protein exhibits enhanced sensitivity and an expanded range of inducibility.
Nucleic acids research 2001;29(10):E47.
2001: Ralf Küppers; A B Sousa; Audrey Sylvia Baur; J G Strickler; Klaus Rajewsky; Martin-Leo Hansmann
Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL.
Molecular medicine (Cambridge, Mass.) 2001;7(5):285-92.
2001: Markus Müschen; Ralf Küppers; Tilmann Spieker; Andreas Bräuninger; Klaus Rajewsky; Martin-Leo Hansmann
Molecular single-cell analysis of Hodgkin- and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes.
Laboratory investigation; a journal of technical methods and pathology 2001;81(3):289-95.
2001: Rafael Casellas; Tien-An Yang Shih; M Kleinewietfeld; J Rakonjac; D Nemazee; Klaus Rajewsky; Michel C Nussenzweig
Contribution of receptor editing to the antibody repertoire.
Science (New York, N.Y.) 2001;291(5508):1541-4.
2001: Ralf Küppers; Andreas Bräuninger; Markus Müschen; Verena Distler; Martin-Leo Hansmann; Klaus Rajewsky
Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions.
Blood 2001;97(3):818-21.
2001: Andreas Bräuninger; W Yang; Hans-Heinrich Wacker; Klaus Rajewsky; Ralf Küppers; Martin-Leo Hansmann
B-cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease.
Blood 2001;97(3):714-9.
2001: Heinz Jacobs; Klaus Rajewsky; Y Fukita; Linda Bross
Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1405):119-25.
2001: Amy Reichlin; Y Hu; Eric Meffre; Hitoshi Nagaoka; S Gong; Manfred Kraus; Klaus Rajewsky; Michel C Nussenzweig
B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta.
The Journal of experimental medicine 2001;193(1):13-23.
2000: Markus Müschen; Daniel Re; Berit Jungnickel; Volker Diehl; Klaus Rajewsky; Ralf Küppers
Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction.
The Journal of experimental medicine 2000;192(12):1833-40.
2000: Linda Bross; Y Fukita; F McBlane; Corinne Démollière; Klaus Rajewsky; Heinz Jacobs
DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation.
Immunity 2000;13(5):589-97.
2000: Tilmann Spieker; Julia Kurth; Ralf Küppers; Klaus Rajewsky; Andreas Bräuninger; Martin-Leo Hansmann
Molecular single-cell analysis of the clonal relationship of small Epstein-Barr virus-infected cells and Epstein-Barr virus-harboring Hodgkin and Reed/Sternberg cells in Hodgkin disease.
Blood 2000;96(9):3133-8.
2000: Markus Müschen; Daniel Re; Andreas Bräuninger; Jürgen Wolf; Martin-Leo Hansmann; Volker Diehl; Ralf Küppers; Klaus Rajewsky
Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells.
Cancer research 2000;60(20):5640-3.
2000: Gloria Esposito; I Godindagger; Ulf Klein; M L Yaspo; A Cumano; Klaus Rajewsky
Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.
Current biology : CB 2000;10(19):1221-4.
2000: M Maruyama; Kong-Peng Lam; Klaus Rajewsky
Memory B-cell persistence is independent of persisting immunizing antigen.
Nature 2000;407(6804):636-42.
2000: Julia Kurth; Tilmann Spieker; Jochen Wustrow; G J Strickler; L M Hansmann; Klaus Rajewsky; Ralf Küppers
EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency.
Immunity 2000;13(4):485-95.
2000: Holger Babbe; Axel Roers; Ari Waisman; H Lassmann; Norbert Goebels; Reinhard Hohlfeld; Michael Friese; Roland Schröder; Martina Deckert; S Schmidt; Rivka Ravid; Klaus Rajewsky
Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction.
The Journal of experimental medicine 2000;192(3):393-404.
2000: Hirotaka Ogata; Irene Su; Kensuke Miyake; Yoshinori Nagai; Sachiko Akashi; Ingrid Mecklenbräuker; Klaus Rajewsky; Masao Kimoto; Alexander Tarakhovsky
The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells.
The Journal of experimental medicine 2000;192(1):23-9.
2000: Klaus Willenbrock; Axel Roers; B Blöhbaum; Klaus Rajewsky; Martin-Leo Hansmann
CD8(+) T cells in Hodgkin's disease tumor tissue are a polyclonal population with limited clonal expansion but little evidence of selection by antigen.
The American journal of pathology 2000;157(1):171-5.
2000: U Braun; Klaus Rajewsky; Roberta Pelanda
Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7429-34.
2000: Marc Schmidt-Supprian; Wilhelm Bloch; Gilles Courtois; Klaus Addicks; Alain Israël; Klaus Rajewsky; Manolis Pasparakis
NEMO/IKK gamma-deficient mice model incontinentia pigmenti.
Molecular cell 2000;5(6):981-92.
2000: Axel Roers; Martin-Leo Hansmann; Klaus Rajewsky; Ralf Küppers
Single-cell PCR analysis of T helper cells in human lymph node germinal centers.
The American journal of pathology 2000;156(3):1067-71.
2000: Gloria Esposito; G Texido; UA Betz; H Gu; Werner Muller; Ulf Klein; Klaus Rajewsky
Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1166-71.
2000: G Texido; I H Su; Ingrid Mecklenbräuker; Kaoru Saijo; Sami Malek; Stephen Desiderio; Klaus Rajewsky; Alexander Tarakhovsky
The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation.
Molecular and cellular biology 2000;20(4):1227-33.
2000: H Kanzler; Ralf Küppers; S Helmes; H H Wacker; A Chott; Martin-Leo Hansmann; Klaus Rajewsky
Hodgkin and Reed-Sternberg-like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell-derived clones: potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease.
Blood 2000;95(3):1023-31.
2000: Berit Jungnickel; Andrea Staratschek-Jox; Andreas Bräuninger; Tilmann Spieker; Jürgen Wolf; Volker Diehl; Martin-Leo Hansmann; Klaus Rajewsky; Ralf Küppers
Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma.
The Journal of experimental medicine 2000;191(2):395-402.
2000: Markus Müschen; Klaus Rajewsky; Andreas Bräuninger; Audrey Sylvia Baur; Joost Oudejans; Axel Roers; Martin-Leo Hansmann; Ralf Küppers
Rare occurrence of classical Hodgkin's disease as a T cell lymphoma.
The Journal of experimental medicine 2000;191(2):387-94.
1999: Ralf Küppers; Ulf Klein; Martin-Leo Hansmann; Klaus Rajewsky
Cellular origin of human B-cell lymphomas.
The New England journal of medicine 1999;341(20):1520-9.
1999: Manfred Kraus; Kaoru Saijo; Raul M Torres; Klaus Rajewsky
Ig-alpha cytoplasmic truncation renders immature B cells more sensitive to antigen contact.
Immunity 1999;11(5):537-45.
1999: Manuel Montesinos-Rongen; Axel Roers; Ralf Küppers; Klaus Rajewsky; Martin-Leo Hansmann
Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease.
Blood 1999;94(5):1755-60.
1999: Kong-Peng Lam; Klaus Rajewsky
B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development.
The Journal of experimental medicine 1999;190(4):471-7.
1999: Andreas Bräuninger; Martin-Leo Hansmann; JG Strickler; R Dummer; G Burg; Klaus Rajewsky; Ralf Küppers
Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma.
The New England journal of medicine 1999;340(16):1239-47.
1999: D Friedmann; Nurit Yachimovich; Gustavo Mostoslavsky; Y Pewzner-Jung; Arie Ben-Yehuda; Klaus Rajewsky; Dan Eilat
Production of high affinity autoantibodies in autoimmune New Zealand Black/New Zealand white F1 mice targeted with an anti-DNA heavy chain.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4406-16.
1999: Andreas Bräuninger; Ralf Küppers; Tilmann Spieker; Reiner Siebert; JG Strickler; Brigitte Schlegelberger; Klaus Rajewsky; Martin-Leo Hansmann
Molecular analysis of single B cells from T-cell-rich B-cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells.
Blood 1999;93(8):2679-87.
1999: XF Qin; S Schwers; Wenjie Yu; F Nina Papavasiliou; H Suh; André Nussenzweig; Klaus Rajewsky; Michel C Nussenzweig
Secondary V(D)J recombination in B-1 cells.
Nature 1999;397(6717):355-9.
1999: Robert Endres; Marat B Alimzhanov; Thomas Plitz; A Fütterer; Marie H Kosco-Vilbois; Sergei A Nedospasov; Klaus Rajewsky; Klaus Pfeffer
Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells.
The Journal of experimental medicine 1999;189(1):159-68.
1999: Tatiana I Novobrantseva; Verena Donatz; Roberta Pelanda; Werner Muller; Klaus Rajewsky; A Ehlich
Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice.
The Journal of experimental medicine 1999;189(1):75-88.
1999: Heinz Jacobs; andrea puglisi; Klaus Rajewsky; Y Fukita
Tuning somatic hypermutation by transcription.
Current topics in microbiology and immunology 1999;246():149-58; discussion 159.
1999: Ulf Klein; Klaus Rajewsky; Ralf Küppers
Phenotypic and molecular characterization of human peripheral blood B-cell subsets with special reference to N-region addition and J kappa-usage in V kappa J kappa-joints and kappa/lambda-ratios in naive versus memory B-cell subsets to identify traces of receptor editing processes.
Current topics in microbiology and immunology 1999;246():141-6; discussion 147.
1998: UA Betz; Wilhelm Bloch; M van den Broek; K Yoshida; T Taga; T Kishimoto; K Addicks; Klaus Rajewsky; Werner Muller
Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects.
The Journal of experimental medicine 1998;188(10):1955-65.
1998: Ulf Klein; Klaus Rajewsky; Ralf Küppers
Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells.
The Journal of experimental medicine 1998;188(9):1679-89.
1998: Norbert Wagner; Jürgen Löhler; T F Tedder; Klaus Rajewsky; Werner Muller; D A Steeber
L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.
European journal of immunology 1998;28(11):3832-9.
1998: Y Pewzner-Jung; D Friedmann; E Sonoda; S Jung; Klaus Rajewsky; Dan Eilat
B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4634-45.
1998: Kong-Peng Lam; Klaus Rajewsky
Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13171-5.
1998: Laura Pasqualucci; Anna Migliazza; N Fracchiolla; Christopher M William; Antonino Neri; Luca Baldini; Raju S K Chaganti; Ulf Klein; Ralf Küppers; Klaus Rajewsky; Riccardo Dalla-Favera
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11816-21.
1998: Johannes Irsch; S Nitsch; Martin-Leo Hansmann; Klaus Rajewsky; Hans Tesch; Volker Diehl; A Jox; Ralf Küppers; Andreas Radbruch
Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10117-22.
1998: Axel Roers; Manuel Montesinos-Rongen; Martin-Leo Hansmann; Klaus Rajewsky; Ralf Küppers
Amplification of TCRbeta gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal.
European journal of immunology 1998;28(8):2424-31.
1998: Vivien Chan; Ingrid Mecklenbräuker; Irene Su; G Texido; Michael Leitges; R Carsetti; Clifford A Lowell; Klaus Rajewsky; Kensuke Miyake; Alexander Tarakhovsky
The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
The Journal of experimental medicine 1998;188(1):93-101.
1998: Y Fukita; Heinz Jacobs; Klaus Rajewsky
Somatic hypermutation in the heavy chain locus correlates with transcription.
Immunity 1998;9(1):105-14.
1998: Heinz Jacobs; Y Fukita; G T van der Horst; J de Boer; Geert Weeda; Jeroen Essers; Niels De Wind; Bevin P Engelward; Leona D Samson; S Verbeek; Josiane Ménissier de Murcia; G de Murcia; Hein te Riele; Klaus Rajewsky
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.
The Journal of experimental medicine 1998;187(11):1735-43.
1998: Rafael Casellas; André Nussenzweig; Robert Wuerffel; Roberta Pelanda; Amy Reichlin; H Suh; XF Qin; Eva Besmer; Amy L Kenter; Klaus Rajewsky; Michel C Nussenzweig
Ku80 is required for immunoglobulin isotype switching.
The EMBO journal 1998;17(8):2404-11.
1998: Ulf Klein; T Goossens; M Fischer; H Kanzler; A Braeuninger; Klaus Rajewsky; Ralf Küppers
Somatic hypermutation in normal and transformed human B cells.
Immunological reviews 1998;162():261-80.
1998: Frieder Schwenk; R Kuhn; P O Angrand; Klaus Rajewsky; A F Stewart
Temporally and spatially regulated somatic mutagenesis in mice.
Nucleic acids research 1998;26(6):1427-32.
1998: Ralf Küppers; Klaus Rajewsky; A Braeuninger; Martin-Leo Hansmann
L&H cells in lymphocyte-predominant Hodgkin's disease.
The New England journal of medicine 1998;338(11):763-4; author reply 764-5.
1998: Björn E Clausen; jean-marc waldburger; Frieder Schwenk; Emmanuèle Barras; Bernard Mach; Klaus Rajewsky; Irmgard Förster; Walter Reith
Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice.
Immunity 1998;8(2):143-55.
1998: Ralf Küppers; Martin-Leo Hansmann; Klaus Rajewsky
Clonality and germinal centre B-cell derivation of Hodgkin/Reed-Sternberg cells in Hodgkin's disease.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9 Suppl 5():S17-20.
1998: Ralf Küppers; Klaus Rajewsky
The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease.
Annual review of immunology 1998;16():471-93.
1997: Roberta Pelanda; Stephan Schwers; E Sonoda; Raul M Torres; D Nemazee; Klaus Rajewsky
Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification.
Immunity 1997;7(6):765-75.
1997: F Nina Papavasiliou; Rafael Casellas; H Suh; XF Qin; Eva Besmer; Roberta Pelanda; D Nemazee; Klaus Rajewsky; Michel C Nussenzweig
V(D)J recombination in mature B cells: a mechanism for altering antibody responses.
Science (New York, N.Y.) 1997;278(5336):298-301.
1997: Frieder Schwenk; B Sauer; N Kukoc; R Hoess; Werner Muller; C Kocks; Ralf Kühn; Klaus Rajewsky
Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains.
Journal of immunological methods 1997;207(2):203-12.
1997: Kong-Peng Lam; Ralf Kühn; Klaus Rajewsky
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.
Cell 1997;90(6):1073-83.
1997: A Braeuninger; Ralf Küppers; JG Strickler; Hans-Heinrich Wacker; Klaus Rajewsky; Martin-Leo Hansmann
Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9337-42.
1997: Marat B Alimzhanov; Dmitry V Kuprash; Marie H Kosco-Vilbois; A Luz; Regina L Turetskaya; A Tarakhovsky; Klaus Rajewsky; Sergei A Nedospasov; Klaus Pfeffer
Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9302-7.
1997: Ralf Küppers; Klaus Rajewsky; Martin-Leo Hansmann
Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression.
European journal of immunology 1997;27(6):1398-405.
1997: T Kaisho; Frieder Schwenk; Klaus Rajewsky
The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses.
Science (New York, N.Y.) 1997;276(5311):412-5.
1997: R C Rickert; J Roes; Klaus Rajewsky
B lymphocyte-specific, Cre-mediated mutagenesis in mice.
Nucleic acids research 1997;25(6):1317-8.
1997: E Sonoda; Y Pewzner-Jung; Stephan Schwers; S Taki; S Jung; Dan Eilat; Klaus Rajewsky
B cell development under the condition of allelic inclusion.
Immunity 1997;6(3):225-33.
1997: Ulf Klein; Ralf Küppers; Klaus Rajewsky
Evidence for a large compartment of IgM-expressing memory B cells in humans.
Blood 1997;89(4):1288-98.
1997: Klaus Rajewsky; H Kanzler; Martin-Leo Hansmann; Ralf Küppers
Normal and malignant B-cell development with special reference to Hodgkin's disease.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1997;8 Suppl 2():79-81.
1996: UA Betz; C A Vosshenrich; Klaus Rajewsky; Werner Muller
Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination.
Current biology : CB 1996;6(10):1307-16.
1996: H Kanzler; Ralf Küppers; Martin-Leo Hansmann; Klaus Rajewsky
Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.
The Journal of experimental medicine 1996;184(4):1495-505.
1996: Roberta Pelanda; S Schaal; Raul M Torres; Klaus Rajewsky
A prematurely expressed Ig(kappa) transgene, but not V(kappa)J(kappa) gene segment targeted into the Ig(kappa) locus, can rescue B cell development in lambda5-deficient mice.
Immunity 1996;5(3):229-39.
1996: G Texidó; H Jacobs; M Meiering; Ralf Kühn; J Roes; Werner Muller; S Gilfillan; H Fujiwara; H Kikutani; N Yoshida; R Amakawa; C Benoist; D Mathis; T Kishimoto; T W Mak; Klaus Rajewsky
Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants.
European journal of immunology 1996;26(8):1966-9.
1996: Ralf Küppers; M Hajadi; L Plank; Klaus Rajewsky; Martin-Leo Hansmann
Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human.
European journal of immunology 1996;26(8):1794-800.
1996: Klaus Rajewsky; H Gu; Ralf Kühn; UA Betz; Werner Muller; J Roes; Frieder Schwenk
Conditional gene targeting.
The Journal of clinical investigation 1996;98(3):600-3.
1996: N Wagner; J Löhler; EJ Kunkel; Klaus Ley; E Leung; G Krissansen; Klaus Rajewsky; Werner Muller
Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue.
Nature 1996;382(6589):366-70.
1996: Klaus Rajewsky
Clonal selection and learning in the antibody system.
Nature 1996;381(6585):751-8.
1996: Raul M Torres; H Flaswinkel; Michael Reth; Klaus Rajewsky
Aberrant B cell development and immune response in mice with a compromised BCR complex.
Science (New York, N.Y.) 1996;272(5269):1804-8.
1996: H Kanzler; Martin-Leo Hansmann; U Kapp; Jürgen Wolf; Volker Diehl; Klaus Rajewsky; Ralf Küppers
Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient.
Blood 1996;87(8):3429-36.
1996: Ralf Küppers; H Kanzler; Martin-Leo Hansmann; Klaus Rajewsky
Immunoglobulin V genes in Reed-Sternberg cells.
The New England journal of medicine 1996;334(6):404; author reply 405-6.
1996: D Löffert; A Ehlich; Werner Muller; Klaus Rajewsky
Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development.
Immunity 1996;4(2):133-44.
1996: Ralf Küppers; H Kanzler; Martin-Leo Hansmann; Klaus Rajewsky
Single cell analysis of Hodgkin/Reed-Sternberg cells.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1996;7 Suppl 4():27-30.
1995: Frieder Schwenk; U Baron; Klaus Rajewsky
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.
Nucleic acids research 1995;23(24):5080-1.
1995: Ralf Küppers; Klaus Rajewsky; M Zhao; G Simons; R Laumann; R Fischer; Martin-Leo Hansmann
Hodgkin's disease: clonal Ig gene rearrangements in Hodgkin and Reed-Sternberg cells picked from histological sections.
Annals of the New York Academy of Sciences 1995;764():523-4.
1995: Ulf Klein; Ralf Küppers; Klaus Rajewsky
Variable-region gene analysis of B-cell subsets derived from a 4-year-old child. Somatically mutated memory B cells accumulate in the peripheral blood already at young age.
Annals of the New York Academy of Sciences 1995;764():189-91.
1995: Ralf Kühn; Frieder Schwenk; M Aguet; Klaus Rajewsky
Inducible gene targeting in mice.
Science (New York, N.Y.) 1995;269(5229):1427-9.
1995: Ralf Küppers; K Willenbrock; Klaus Rajewsky; Martin-Leo Hansmann
Detection of clonal lambda light chain gene rearrangements in frozen and paraffin-embedded tissues by polymerase chain reaction.
The American journal of pathology 1995;147(3):806-14.
1995: Alexander Tarakhovsky; S B Kanner; J Hombach; J A Ledbetter; Werner Muller; Nigel Killeen; Klaus Rajewsky
A role for CD5 in TCR-mediated signal transduction and thymocyte selection.
Science (New York, N.Y.) 1995;269(5223):535-7.
1995: R C Rickert; Klaus Rajewsky; J Roes
Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.
Nature 1995;376(6538):352-5.
1995: Ulf Klein; G Klein; B Ehlin-Henriksson; Klaus Rajewsky; Ralf Küppers
Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes.
Molecular medicine (Cambridge, Mass.) 1995;1(5):495-505.
1995: S Taki; Frieder Schwenk; Klaus Rajewsky
Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region gene inserted into the DQ52-JH region of the immunoglobulin heavy chain locus.
European journal of immunology 1995;25(7):1888-96.
1995: J Roes; Werner Muller; Klaus Rajewsky
Mouse anti-mouse IgD monoclonal antibodies generated in IgD-deficient mice.
Journal of immunological methods 1995;183(2):231-7.
1995: Ralf Küppers; Martin-Leo Hansmann; Volker Diehl; Klaus Rajewsky
Molecular single-cell analysis of Hodgkin and Reed-Sternberg cells.
Molecular medicine today 1995;1(1):26-30.
1995: Alexander Tarakhovsky; Martin Turner; S Schaal; PJ Mee; L P Duddy; Klaus Rajewsky; Victor L J Tybulewicz
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.
Nature 1995;374(6521):467-70.
1994: Y R Zou; Werner Muller; H Gu; Klaus Rajewsky
Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies.
Current biology : CB 1994;4(12):1099-103.
1994: Ralf Küppers; Klaus Rajewsky; M Zhao; G Simons; R Laumann; R Fischer; Martin-Leo Hansmann
Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10962-6.
1994: Ulf Klein; Ralf Küppers; Klaus Rajewsky
Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.
The Journal of experimental medicine 1994;180(4):1383-93.
1994: Hans Jörg Fehling; W Swat; C Laplace; R Kühn; Klaus Rajewsky; U Müller; Harald von Boehmer
MHC class I expression in mice lacking the proteasome subunit LMP-7.
Science (New York, N.Y.) 1994;265(5176):1234-7.
1994: T Christoph; R Rickert; Klaus Rajewsky
M17: a novel gene expressed in germinal centers.
International immunology 1994;6(8):1203-11.
1994: H Gu; Jamey D Marth; P C Orban; H Mossmann; Klaus Rajewsky
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.
Science (New York, N.Y.) 1994;265(5168):103-6.
1994: A Ehlich; Verena Donatz; Werner Muller; Klaus Rajewsky
Analysis of the B-cell progenitor compartment at the level of single cells.
Current biology : CB 1994;4(7):573-83.
1994: Alexander Tarakhovsky; Werner Muller; Klaus Rajewsky
Lymphocyte populations and immune responses in CD5-deficient mice.
European journal of immunology 1994;24(7):1678-84.
1994: Jürgen Schmitz; A Thiel; R Kühn; Klaus Rajewsky; Werner Muller; Mario Assenmacher; Andreas Radbruch
Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.
The Journal of experimental medicine 1994;179(4):1349-53.
1994: D Löffert; S Schaal; A Ehlich; R R Hardy; Y R Zou; Werner Muller; Klaus Rajewsky
Early B-cell development in the mouse: insights from mutations introduced by gene targeting.
Immunological reviews 1994;137():135-53.
1993: Ralf Küppers; M Zhao; Martin-Leo Hansmann; Klaus Rajewsky
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.
The EMBO journal 1993;12(13):4955-67.
1993: Ulf Klein; Ralf Küppers; Klaus Rajewsky
Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life.
European journal of immunology 1993;23(12):3272-7.
1993: Y R Zou; H Gu; Klaus Rajewsky
Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions.
Science (New York, N.Y.) 1993;262(5137):1271-4.
1993: S Taki; M Meiering; Klaus Rajewsky
Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus.
Science (New York, N.Y.) 1993;262(5137):1268-71.
1993: Ralf Kühn; J Löhler; D Rennick; Klaus Rajewsky; Werner Muller
Interleukin-10-deficient mice develop chronic enterocolitis.
Cell 1993;75(2):263-74.
1993: H Gu; Y R Zou; Klaus Rajewsky
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.
Cell 1993;73(6):1155-64.
1993: Shunichi Takeda; Y R Zou; H Bluethmann; D Kitamura; U Muller; Klaus Rajewsky
Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.
The EMBO journal 1993;12(6):2329-36.
1993: A Ehlich; S Schaal; H Gu; D Kitamura; Werner Muller; Klaus Rajewsky
Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development.
Cell 1993;72(5):695-704.
1993: Y R Zou; S Takeda; Klaus Rajewsky
Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa.
The EMBO journal 1993;12(3):811-20.
1993: S Jung; Klaus Rajewsky; Andreas Radbruch
Shutdown of class switch recombination by deletion of a switch region control element.
Science (New York, N.Y.) 1993;259(5097):984-7.
1993: J Roes; Klaus Rajewsky
Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.
The Journal of experimental medicine 1993;177(1):45-55.
1992: B Schittek; Klaus Rajewsky
Natural occurrence and origin of somatically mutated memory B cells in mice.
The Journal of experimental medicine 1992;176(2):427-38.
1992: D Kitamura; A Kudo; S Schaal; Werner Muller; F Melchers; Klaus Rajewsky
A critical role of lambda 5 protein in B cell development.
Cell 1992;69(5):823-31.
1992: H Gu; Irmgard Förster; Klaus Rajewsky
Study of murine B-cell development through analysis of immunoglobulin variable region genes.
Annals of the New York Academy of Sciences 1992;651():304-10.
1992: S Taki; M Schmitt; D Tarlinton; Irmgard Förster; Klaus Rajewsky
T cell-dependent antibody production by Ly-1 B cells.
Annals of the New York Academy of Sciences 1992;651():328-35.
1992: Klaus Rajewsky
Early and late B-cell development in the mouse.
Current opinion in immunology 1992;4(2):171-6.
1992: T Simon; Klaus Rajewsky
A functional antibody mutant with an insertion in the framework region 3 loop of the VH domain: implications for antibody engineering.
Protein engineering 1992;5(3):229-34.
1992: D Kitamura; Klaus Rajewsky
Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion.
Nature 1992;356(6365):154-6.
1992: D Tarlinton; Irmgard Förster; Klaus Rajewsky
An explanation for the defect in secretion of IgM Mott cells and their predominant occurrence in the Ly-1 B cell compartment.
European journal of immunology 1992;22(2):531-9.
1992: U Weiss; R Zoebelein; Klaus Rajewsky
Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen.
European journal of immunology 1992;22(2):511-7.
1992: M Zhao; Ralf Küppers; Martin-Leo Hansmann; Johann Lorenzen; Klaus Rajewsky; R Fischer
[Detection of clonal immunoglobulin rearrangements in paraffin embedded tissues by PCR].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1992;76():243-7.
1991: J Roes; Klaus Rajewsky
Cell autonomous expression of IgD is not essential for the maturation of conventional B cells.
International immunology 1991;3(12):1367-71.
1991: Ralf Kühn; Klaus Rajewsky; Werner Muller
Generation and analysis of interleukin-4 deficient mice.
Science (New York, N.Y.) 1991;254(5032):707-10.
1991: Irmgard Förster; Werner Muller; B Schittek; Klaus Rajewsky
Generation of long-lived B cells in germ-free mice.
European journal of immunology 1991;21(7):1779-82.
1991: H Gu; D Tarlinton; Werner Muller; Klaus Rajewsky; Irmgard Förster
Most peripheral B cells in mice are ligand selected.
The Journal of experimental medicine 1991;173(6):1357-71.
1991: H Gu; D Kitamura; Klaus Rajewsky
B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D mu protein and selection of DH element reading frames.
Cell 1991;65(1):47-54.
1991: D Kitamura; J Roes; Ralf Kühn; Klaus Rajewsky
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene.
Nature 1991;350(6317):423-6.
1991: Werner Muller; Ralf Kühn; Klaus Rajewsky
Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia.
European journal of immunology 1991;21(4):921-5.
1991: B Schittek; Klaus Rajewsky; Irmgard Förster
Dividing cells in bone marrow and spleen incorporate bromodeoxyuridine with high efficiency.
European journal of immunology 1991;21(1):235-8.
1991: Irmgard Förster; H Gu; Werner Muller; M Schmitt; D Tarlinton; Klaus Rajewsky
CD5 B cells in the mouse.
Current topics in microbiology and immunology 1991;173():247-51.
1990: U Weiss; Klaus Rajewsky
The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.
The Journal of experimental medicine 1990;172(6):1681-9.
1990: B Schittek; Klaus Rajewsky
Maintenance of B-cell memory by long-lived cells generated from proliferating precursors.
Nature 1990;346(6286):749-51.
1990: H Gu; Irmgard Förster; Klaus Rajewsky
Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation.
The EMBO journal 1990;9(7):2133-40.
1990: Irmgard Förster; Klaus Rajewsky
The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4781-4.
1990: T Simon; Klaus Rajewsky
Antibody domain mutants demonstrate autonomy of the antigen binding site.
The EMBO journal 1990;9(4):1051-6.
1990: P Vieira; Klaus Rajewsky
Persistence of memory B cells in mice deprived of T cell help.
International immunology 1990;2(6):487-94.
1989: Werner Muller; U Rüther; P Vieira; J Hombach; Michael Reth; Klaus Rajewsky
Membrane-bound IgM obstructs B cell development in transgenic mice.
European journal of immunology 1989;19(5):923-8.
1989: A Belyavsky; T Vinogradova; Klaus Rajewsky
PCR-based cDNA library construction: general cDNA libraries at the level of a few cells.
Nucleic acids research 1989;17(8):2919-32.
1989: J Roes; K Hüppi; Klaus Rajewsky; F Sablitzky
V gene rearrangement is required to fully activate the hypermutation mechanism in B cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(3):1022-6.
1989: Klaus Rajewsky
Immunological memories.
Immunology. Supplement 1989;2():50-2; discussion 53.
1989: C Kocks; Klaus Rajewsky
Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways.
Annual review of immunology 1989;7():537-59.
1989: Klaus Rajewsky; H Gu; P Vieira; Irmgard Förster
Growth and selection of B cells in vivo.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():209-17.
1989: B Schittek; E Unkelbach; Klaus Rajewsky
Violation of allelic exclusion of the T cell receptor beta genes in a helper T cell clone.
International immunology 1989;1(3):273-80.
1989: Irmgard Förster; P Vieira; Klaus Rajewsky
Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse.
International immunology 1989;1(4):321-31.
1988: Irmgard Förster; H Gu; Klaus Rajewsky
Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment.
The EMBO journal 1988;7(12):3693-703.
1988: J Hombach; L Leclercq; Andreas Radbruch; Klaus Rajewsky; Michael Reth
A novel 34-kd protein co-isolated with the IgM molecule in surface IgM-expressing cells.
The EMBO journal 1988;7(11):3451-6.
1988: C Kocks; Klaus Rajewsky
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8206-10.
1988: D Allen; T Simon; F Sablitzky; Klaus Rajewsky; A Cumano
Antibody engineering for the analysis of affinity maturation of an anti-hapten response.
The EMBO journal 1988;7(7):1995-2001.
1988: P Vieira; Klaus Rajewsky
The half-lives of serum immunoglobulins in adult mice.
European journal of immunology 1988;18(2):313-6.
1988: J Hombach; F Sablitzky; Klaus Rajewsky; Michael Reth
Transfected plasmacytoma cells do not transport the membrane form of IgM to the cell surface.
The Journal of experimental medicine 1988;167(2):652-7.
1988: T Simon; Klaus Rajewsky
'Enhancer-constitutive' vectors for the expression of recombinant antibodies.
Nucleic acids research 1988;16(1):354.
1988: D Allen; A Cumano; T Simon; F Sablitzky; Klaus Rajewsky
Modulation of antibody binding affinity by somatic mutation.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1988;3():1-8.
1987: Klaus Rajewsky; Irmgard Förster; A Cumano
Evolutionary and somatic selection of the antibody repertoire in the mouse.
Science (New York, N.Y.) 1987;238(4830):1088-94.
1987: N Yoshida; Andreas Radbruch; Klaus Rajewsky
Ig gene rearrangement and expression in the progeny of B-cell progenitors in the course of clonal expansion in bone marrow cultures.
The EMBO journal 1987;6(9):2735-41.
1987: D Allen; A Cumano; R Dildrop; C Kocks; Klaus Rajewsky; N Rajewsky; J Roes; F Sablitzky; M Siekevitz
Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development.
Immunological reviews 1987;96():5-22.
1987: M Siekevitz; C Kocks; Klaus Rajewsky; R Dildrop
Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses.
Cell 1987;48(5):757-70.
1985: R Dildrop; U Krawinkel; E Winter; Klaus Rajewsky
VH-gene expression in murine lipopolysaccharide blasts distributes over the nine known VH-gene groups and may be random.
European journal of immunology 1985;15(11):1154-6.
1984: R Dildrop; J Bovens; M Siekevitz; Konrad Beyreuther; Klaus Rajewsky
A V region determinant (idiotope) expressed at high frequency in B lymphocytes is encoded by a large set of antibody structural genes.
The EMBO journal 1984;3(3):517-23.
1983: U Krawinkel; G Zoebelein; M Brüggemann; Andreas Radbruch; Klaus Rajewsky
Recombination between antibody heavy chain variable-region genes: evidence for gene conversion.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(16):4997-5001.
1982: R Dildrop; M Brüggemann; A Radbruch; Klaus Rajewsky; Konrad Beyreuther
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.
The EMBO journal 1982;1(5):635-40.