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Ray Rajotte

Research Profile

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Islets of Langerhans

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P Thompson; A Turner; Richard N Pierson III; J Avila; Agnes M Azimzadeh; I R Badell; J Cano; X Cheng; B Johnson; Gregory S Korbutt; Christian P Larsen; F Leopardi; M Lowe; Ray V Rajotte; Gina R Rayat; J Robertson; Mingqing Song; Elizabeth Strobert; Allan D Kirk
Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival.
P Thompson; J Avila; I R Badell; J Cano; N Iwakoshi; Gregory S Korbutt; Christian P Larsen; F Leopardi; M Lowe; Ray V Rajotte; Gina R Rayat; R Ruhil; M Song; E Strobert; Allan D Kirk
Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function.
Olga Hrytsenko; Richard Krause; Bill Pohajdak; Ray V Rajotte; Gina R Rayat; Bao-You Xu; James R Wright
Lifelong stable human insulin expression in transgenic tilapia expressing a humanized tilapia insulin gene.

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All Publications

2012: P Thompson; A Turner; Richard N Pierson III; J Avila; Agnes M Azimzadeh; I R Badell; J Cano; X Cheng; B Johnson; Gregory S Korbutt; Christian P Larsen; F Leopardi; M Lowe; Ray V Rajotte; Gina R Rayat; J Robertson; Mingqing Song; Elizabeth Strobert; Allan D Kirk
Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(7):1765-75.
2011: P Thompson; J Avila; I R Badell; J Cano; N Iwakoshi; Gregory S Korbutt; Christian P Larsen; F Leopardi; M Lowe; Ray V Rajotte; Gina R Rayat; R Ruhil; M Song; E Strobert; Allan D Kirk
Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(12):2593-602.
2011: Olga Hrytsenko; Richard Krause; Bill Pohajdak; Ray V Rajotte; Gina R Rayat; Bao-You Xu; James R Wright
Lifelong stable human insulin expression in transgenic tilapia expressing a humanized tilapia insulin gene.
Transgenic research 2011;20(6):1397-8.
2011: P Thompson; K Cardona; M Russell; I R Badell; V Shaffer; Gregory S Korbutt; Gina R Rayat; J Cano; M Song; W Jiang; E Strobert; Ray V Rajotte; Thomas C Pearson; Allan D Kirk; Christian P Larsen
CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(5):947-57.
2010: Hossein Arefanian; Eric B Tredget; Ray V Rajotte; Ronald G Gill; Gregory S Korbutt; Gina R Rayat
Short-term administrations of a combination of anti-LFA-1 and anti-CD154 monoclonal antibodies induce tolerance to neonatal porcine islet xenografts in mice.
Diabetes 2010;59(4):958-66.
2009: Richard J Owen; John R Mercer; Faisal Al-Saif; Michele Molinari; Robert Ashforth; Ray V Rajotte; Barbara Conner-spady; A M James Shapiro
Portal vein embolization with radiolabeled polyvinyl alcohol particles in a swine model: hepatic distribution and implications for pancreatic islet cell transplantation.
Cardiovascular and interventional radiology 2009;32(3):499-507.
2009: Karen Seeberger; Alana Eshpeter; Ray V Rajotte; Gregory S Korbutt
Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: epithelial-mesenchymal transition is an artifact of cell culture.
Laboratory investigation; a journal of technical methods and pathology 2009;89(2):110-21.
2009: Reza Jalili; Farshad Forouzandeh; Alireza Moeenrezakhanlou; Gina R Rayat; Ray V Rajotte; Hasan Uludag; Aziz Ghahary
Mouse pancreatic islets are resistant to indoleamine 2,3 dioxygenase-induced general control nonderepressible-2 kinase stress pathway and maintain normal viability and function.
The American journal of pathology 2009;174(1):196-205.
2008: Alana Eshpeter; J Jiang; M Au; Ray V Rajotte; K Lu; J S Lebkowski; A S Majumdar; Gregory S Korbutt
In vivo characterization of transplanted human embryonic stem cell-derived pancreatic endocrine islet cells.
Cell proliferation 2008;41(6):843-58.
2008: Ray V Rajotte
Moving towards clinical application.
Xenotransplantation 2008;15(2):113-5.
2008: Ray V Rajotte
Isolation and assessment of islet quality.
Xenotransplantation 2008;15(2):93-5.
2008: Tsunehiro Kobayashi; Hossein Arefanian; George Harb; Eric B Tredget; Ray V Rajotte; Gregory S Korbutt; Gina R Rayat
Prolonged survival of microencapsulated neonatal porcine islet xenografts in immune-competent mice without antirejection therapy.
Cell transplantation 2008;17(10-11):1243-56.
2008: Eric B Tredget; Hossein Arefanian; Ronald G Gill; Ray V Rajotte; Gina R Rayat
Monotherapy with anti-LFA-1 monoclonal antibody promotes long-term survival of rat islet xenografts.
Cell transplantation 2008;17(6):599-608.
2008: Jannette M Dufour; Brinda Dass; Katie R Halley; Gregory S Korbutt; Doreen E Dixon; Ray V Rajotte
Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells.
Cell transplantation 2008;17(5):525-34.
2008: Jannette M Dufour; Sarah J Lord; Tatsuya Kin; Gina R Rayat; Doreen E Dixon; R Chris Bleackley; Gregory S Korbutt; Ray V Rajotte
Comparison of successful and unsuccessful islet/Sertoli cell cotransplant grafts in streptozotocin-induced diabetic mice.
Cell transplantation 2008;16(10):1029-38.
2007: Reza Jalili; Gina R Rayat; Ray V Rajotte; Aziz Ghahary
Suppression of islet allogeneic immune response by indoleamine 2,3 dioxygenase-expressing fibroblasts.
Journal of cellular physiology 2007;213(1):137-43.
2007: Hossein Arefanian; Eric B Tredget; Ray V Rajotte; Gregory S Korbutt; Ronald G Gill; Gina R Rayat
Combination of anti-CD4 with anti-LFA-1 and anti-CD154 monoclonal antibodies promotes long-term survival and function of neonatal porcine islet xenografts in spontaneously diabetic NOD mice.
Cell transplantation 2007;16(8):787-98.
2007: Jonathan R T Lakey; Tatsuya Kin; Garth L Warnock; A M James Shapiro; Panagiotis Tsapogas; Sharleen Imes; Gregory S Korbutt; Norman M Kneteman; Ray V Rajotte; Edmond A Ryan
Long-term graft function after allogeneic islet transplantation.
Cell transplantation 2007;16(4):441-6.
2007: Bin Luo; W F N Chan; S J Lord; Sulaiman A Nanji; Ray V Rajotte; A M James Shapiro; Colin C Anderson
Diabetes induces rapid suppression of adaptive immunity followed by homeostatic T-cell proliferation.
Scandinavian journal of immunology 2007;65(1):22-31.
2006: Tsunehiro Kobayashi; George Harb; Ray V Rajotte; Gregory S Korbutt; Aaron G Mallett; Hossein Arefanian; Dereck Mok; Gina R Rayat
Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts.
Xenotransplantation 2006;13(6):547-59.
2006: Juliet A Emamaullee; A M James Shapiro; Ray V Rajotte; Gregory S Korbutt; John Elliott
Neonatal porcine islets exhibit natural resistance to hypoxia-induced apoptosis.
Transplantation 2006;82(7):945-52.
2006: Simonetta Sipione; Katia C Simmen; Sarah J Lord; Bruce Motyka; Catherine Ewen; Irene Shostak; Gina R Rayat; Jannette M Dufour; Gregory S Korbutt; Ray V Rajotte; R Chris Bleackley
Identification of a novel human granzyme B inhibitor secreted by cultured sertoli cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5051-8.
2006: Rizwan A Manji; Lin-Fu Zhu; Nimrit K Nijjar; David C Rayner; Gregory S Korbutt; Thomas A Churchill; Ray V Rajotte; Arvind Koshal; David B Ross
Glutaraldehyde-fixed bioprosthetic heart valve conduits calcify and fail from xenograft rejection.
Circulation 2006;114(4):318-27.
2006: Kenneth Cardona; Gregory S Korbutt; Zvonimir Milas; James Lyon; Jose Cano; Wanhong Jiang; Hameeda Bello-Laborn; Brad Hacquoil; Elizabeth Strobert; Shivaprakash Gangappa; Collin J Weber; Thomas C Pearson; Ray V Rajotte; Christian P Larsen
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.
Nature medicine 2006;12(3):304-6.
2006: Karen Seeberger; Jannette M Dufour; Andrew M James Shapiro; Jonathan R T Lakey; Ray V Rajotte; Gregory S Korbutt
Expansion of mesenchymal stem cells from human pancreatic ductal epithelium.
Laboratory investigation; a journal of technical methods and pathology 2006;86(2):141-53.
2005: Stephanie M Gustavson; Ray V Rajotte; David Hunkeler; Jonathan R T Lakey; Dale S Edgerton; Doss W Neal; Wanda L Snead; Angelina R Penaloza; Alan D Cherrington
Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(10):2368-77.
2005: Jannette M Dufour; Ray V Rajotte; Mark Zimmerman; Alireza Rezania; Tatsuya Kin; Doreen E Dixon; Gregory S Korbutt
Development of an ectopic site for islet transplantation, using biodegradable scaffolds.
Tissue engineering 2005;11(9-10):1323-31.
2005: Juliet A Emamaullee; Ray V Rajotte; Peter Liston; Robert G Korneluk; Jonathan R T Lakey; A M James Shapiro; John Elliott
XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes.
Diabetes 2005;54(9):2541-8.
2005: Steven R Meyer; Jayan Nagendran; Leena S Desai; Gina R Rayat; Thomas A Churchill; Colin C Anderson; Ray V Rajotte; Jonathan R T Lakey; David B Ross
Decellularization reduces the immune response to aortic valve allografts in the rat.
The Journal of thoracic and cardiovascular surgery 2005;130(2):469-76.
2005: Jannette M Dufour; Meredith Hamilton; Ray V Rajotte; Gregory S Korbutt
Neonatal porcine Sertoli cells inhibit human natural antibody-mediated lysis.
Biology of reproduction 2005;72(5):1224-31.
2005: Tatsuya Kin; Gregory S Korbutt; Tsunehiro Kobayashi; Jannette M Dufour; Ray V Rajotte
Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets.
Diabetes 2005;54(4):1032-9.
2005: A M James Shapiro; Heather L Gallant; Er Geng Hao; Jonathan R T Lakey; Tara McCready; Ray V Rajotte; Randall W Yatscoff; Norman M Kneteman
The portal immunosuppressive storm: relevance to islet transplantation?
Therapeutic drug monitoring 2005;27(1):35-7.
2004: Cale N Street; Jonathan R T Lakey; A M James Shapiro; Sharleen Imes; Ray V Rajotte; Edmond A Ryan; James G Lyon; Tatsuya Kin; Jose Avila; Toshiaki Tsujimura; Gregory S Korbutt
Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome.
Diabetes 2004;53(12):3107-14.
2004: Gregory S Korbutt; A G Mallett; Ziliang Ao; M Flashner; Ray V Rajotte
Improved survival of microencapsulated islets during in vitro culture and enhanced metabolic function following transplantation.
Diabetologia 2004;47(10):1810-8.
2004: Tatsuya Kin; Ray V Rajotte; Gregory S Korbutt
Reassessment of the vascularization of renal subcapsular islet grafts.
Pancreas 2004;29(3):e59-63.
2004: Jacqueline S Manji; Ray V Rajotte; Arvind Koshal; Rizwan A Manji
Increased apoptosis in porcine cardiac xenografts perfused with human ABO plasma containing the anti-B antibody.
Xenotransplantation 2004;11(4):378-9.
2004: Jacqueline S Manji; Ray V Rajotte; Arvind Koshal; Rizwan A Manji
Human anti-A and anti-B antibodies interact with alphaGal antibody affecting xenograft survival.
Xenotransplantation 2004;11(4):376-7.
2004: Tanya M Binette; Karen Seeberger; James G Lyon; Ray V Rajotte; Gregory S Korbutt
Porcine endogenous retroviral nucleic acid in peripheral tissues is associated with migration of porcine cells post islet transplant.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(7):1051-60.
2004: Isabelle Leclerc; Wolfram W Woltersdorf; Gabriela da Silva Xavier; Rebecca L Rowe; Sarah E Cross; Gregory S Korbutt; Ray V Rajotte; Richard Smith; Guy A Rutter
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.
American journal of physiology. Endocrinology and metabolism 2004;286(6):E1023-31.
2004: Cale N Street; Simonetta Sipione; Lisa M H Helms; Tanya M Binette; Ray V Rajotte; R Chris Bleackley; Gregory S Korbutt
Stem cell-based approaches to solving the problem of tissue supply for islet transplantation in type 1 diabetes.
The international journal of biochemistry & cell biology 2004;36(4):667-83.
2004: Jannette M Dufour; Richelle Hemendinger; Craig Halberstadt; Paul Gores; Dwaine F Emerich; Gregory S Korbutt; Ray V Rajotte
Genetically engineered Sertoli cells are able to survive allogeneic transplantation.
Gene therapy 2004;11(8):694-700.
2004: Cale N Street; Jonathan R T Lakey; Karen Seeberger; Lisa M H Helms; Ray V Rajotte; A M James Shapiro; Gregory S Korbutt
Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker.
The Journal of endocrinology 2004;180(2):213-25.
2004: Cale N Street; Jonathan R T Lakey; Ray V Rajotte; A M James Shapiro; Timothy J Kieffer; James G Lyon; Tatsuya Kin; Gregory S Korbutt
Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently.
The review of diabetic studies : RDS 2004;1(2):66-79.
2004: Bryan Norrie; Asif Jalil; John R Lakey; Ray V Rajotte; Hasan Uludag
In-situ crosslinking thermoreversible polymers for cell entrapment.
Advances in experimental medicine and biology 2004;553():19-28.
2004: Rizwan A Manji; Ray V Rajotte; Koshal Arvind
Human O red blood cells and pig-to-human xenotransplantation.
Xenotransplantation 2004;11(1):107.
2003: Jannette M Dufour; Ray V Rajotte; Karen Seeberger; Tatsuya Kin; Gregory S Korbutt
Long-term survival of neonatal porcine Sertoli cells in non-immunosuppressed rats.
Xenotransplantation 2003;10(6):577-86.
2003: Jannette M Dufour; Ray V Rajotte; Gregory S Korbutt; Dwaine F Emerich
Harnessing the immunomodulatory properties of Sertoli cells to enable xenotransplantation in type I diabetes.
Immunological investigations 2003;32(4):275-97.
2003: Richard J Owen; Edmond A Ryan; Kevin O'Kelly; Jonathan R T Lakey; Mairin C McCarthy; Breay W Paty; David L Bigam; Norman M Kneteman; Gregory S Korbutt; Ray V Rajotte; A M James Shapiro
Percutaneous transhepatic pancreatic islet cell transplantation in type 1 diabetes mellitus: radiologic aspects.
Radiology 2003;229(1):165-70.
2003: Gina R Rayat; Ray V Rajotte; James G Lyon; Jannette M Dufour; Brad V Hacquoil; Gregory S Korbutt
Immunization with streptozotocin-treated NOD mouse islets inhibits the onset of autoimmune diabetes in NOD mice.
Journal of autoimmunity 2003;21(1):11-5.
2003: Gina R Rayat; Zachary A Johnson; Joshua Beilke; Gregory S Korbutt; Ray V Rajotte; Ronald G Gill
The degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection.
Diabetes 2003;52(6):1433-40.
2003: Sarah J Lord; Ray V Rajotte; Gregory S Korbutt; R Chris Bleackley
Granzyme B: a natural born killer.
Immunological reviews 2003;193():31-8.
2003: Jannette M Dufour; Ray V Rajotte; Tatsuya Kin; Gregory S Korbutt
Immunoprotection of rat islet xenografts by cotransplantation with sertoli cells and a single injection of antilymphocyte serum.
Transplantation 2003;75(9):1594-6.
2003: Gina R Rayat; Ray V Rajotte; B J Hering; Tanya M Binette; Gregory S Korbutt
In vitro and in vivo expression of Galalpha-(1,3)Gal on porcine islet cells is age dependent.
The Journal of endocrinology 2003;177(1):127-35.
2003: Paul Gores; Daniel H Hayes; M Jane Copeland; Gregory S Korbutt; Craig Halberstadt; Shaun A Kirkpatrick; Ray V Rajotte
Long-term survival of intratesticular porcine islets in nonimmunosuppressed beagles.
Transplantation 2003;75(5):613-8.
2003: Rizwan A Manji; Jacqueline S Manji; Arvind Koshal; Gregory S Korbutt; Ray V Rajotte
Human ABO blood group is important in survival and function of porcine working hearts.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(3):286-93.
2003: Tatsuya Kin; Gregory S Korbutt; Ray V Rajotte
Survival and metabolic function of syngeneic rat islet grafts transplanted in the omental pouch.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(3):281-5.
2003: Wen-Tsoung Lu; Jonathan R T Lakey; Jyuhn-Huarng Juang; B R-S Hsu; Ray V Rajotte
Effect of trypsin inhibitor on islet isolation from fresh and cold preserved rat pancreas.
Transplantation proceedings 2003;35(1):488-9.
2003: Cale N Street; Ray V Rajotte; Gregory S Korbutt
Stem cells: a promising source of pancreatic islets for transplantation in type 1 diabetes.
Current topics in developmental biology 2003;58():111-36.
2003: José Oberholzer; A M James Shapiro; Jonathan R T Lakey; Edmond A Ryan; Ray V Rajotte; Gregory S Korbutt; Philippe Morel; Norman M Kneteman
Current status of islet cell transplantation.
Advances in surgery 2003;37():253-82.
2002: Toshiaki Tsujimura; Yoshikazu Kuroda; Tatsuya Kin; Jose G Avila; Ray V Rajotte; Gregory S Korbutt; Edmond A Ryan; A M James Shapiro; Jonathan R T Lakey
Human islet transplantation from pancreases with prolonged cold ischemia using additional preservation by the two-layer (UW solution/perfluorochemical) cold-storage method.
Transplantation 2002;74(12):1687-91.
2002: A M James Shapiro; Er Geng Hao; Jonathan R T Lakey; Diane T Finegood; Ray V Rajotte; Norman M Kneteman
Defining optimal immunosuppression for islet transplantation based on reduced diabetogenicity in canine islet autografts.
Transplantation 2002;74(11):1522-8.
2002: Wen-Tsoung Lu; Jonathan R T Lakey; Jyuhn-Huarng Juang; B R-S Hsu; Ray V Rajotte
Effect of pefabloc on islet isolation from cold preserved rat pancreas.
Transplantation proceedings 2002;34(7):2700-1.
2002: John J Casey; Jonathan R T Lakey; Edmond A Ryan; Breay W Paty; Richard Owen; Kevin O'Kelly; Sulaiman Nanji; Ray V Rajotte; Gregory S Korbutt; David L Bigam; Norman N Kneteman; A M James Shapiro
Portal venous pressure changes after sequential clinical islet transplantation.
Transplantation 2002;74(7):913-5.
2002: Jannette M Dufour; Ray V Rajotte; Gregory S Korbutt
Development of an in vivo model to study testicular morphogenesis.
Journal of andrology 2002;23(5):635-44.
2002: Edmond A Ryan; Jonathan R T Lakey; Breay W Paty; Sharleen Imes; Gregory S Korbutt; Norman M Kneteman; David L Bigam; Ray V Rajotte; A M James Shapiro
Successful islet transplantation: continued insulin reserve provides long-term glycemic control.
Diabetes 2002;51(7):2148-57.
2002: Jonathan R T Lakey; Norman M Kneteman; Ray V Rajotte; Douglas C Wu; David L Bigam; A M James Shapiro
Effect of core pancreas temperature during cadaveric procurement on human islet isolation and functional viability.
Transplantation 2002;73(7):1106-10.
2002: Alex Rabinovitch; Wilma L Suarez-Pinzon; A M James Shapiro; Ray V Rajotte; Robert Power
Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice.
Diabetes 2002;51(3):638-45.
2002: Tatsuya Kin; Ray V Rajotte; Jannette M Dufour; Gregory S Korbutt
Development of an immunoprivileged site to prolong islet allograft survival.
Cell transplantation 2002;11(6):547-52.
2001: Jonathan R T Lakey; Wilma L Suarez-Pinzon; Ken Strynadka; Gregory S Korbutt; Ray V Rajotte; Francisco Soriano; Csaba Szabó; Alex Rabinovitch
Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells.
Laboratory investigation; a journal of technical methods and pathology 2001;81(12):1683-92.
2001: Jonathan R T Lakey; T J Anderson; Ray V Rajotte
Novel approaches to cryopreservation of human pancreatic islets.
Transplantation 2001;72(6):1005-11.
2001: Jonathan R T Lakey; Lisa M H Helms; Tatsuya Kin; Gregory S Korbutt; Ray V Rajotte; A M James Shapiro; Garth L Warnock
Serine-protease inhibition during islet isolation increases islet yield from human pancreases with prolonged ischemia.
Transplantation 2001;72(4):565-70.
2001: A M James Shapiro; Er Geng Hao; Jonathan R T Lakey; W J Yakimets; Thomas A Churchill; Paraskevi G Mitlianga; George K Papadopoulos; John Elliott; Ray V Rajotte; Norman M Kneteman
Novel approaches toward early diagnosis of islet allograft rejection.
Transplantation 2001;71(12):1709-18.
2001: Edmond A Ryan; Jonathan R T Lakey; Ray V Rajotte; Gregory S Korbutt; Tatsuya Kin; Sharleen Imes; Alex Rabinovitch; John Elliott; David L Bigam; Norman M Kneteman; Garth L Warnock; I Larsen; A M James Shapiro
Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol.
Diabetes 2001;50(4):710-9.
2001: CA Fedorow; Locksley E McGann; Gregory S Korbutt; Gina R Rayat; Ray V Rajotte; Jonathan R T Lakey
Osmotic and cryoprotectant permeation characteristics of islet cells isolated from the newborn pig pancreas.
Cell transplantation 2001;10(7):651-9.
2001: Jonathan R T Lakey; Ray V Rajotte; CA Fedorow; M J Taylor
Islet cryopreservation using intracellular preservation solutions.
Cell transplantation 2001;10(7):583-9.
2000: Anthony T Cheung; B Dayanandan; Jamie T Lewis; Gregory S Korbutt; Ray V Rajotte; Michael Bryer-Ash; Michael O Boylan; M Michael Wolfe; Timothy J Kieffer
Glucose-dependent insulin release from genetically engineered K cells.
Science (New York, N.Y.) 2000;290(5498):1959-62.
2000: Wilma L Suarez-Pinzon; Gregory S Korbutt; Robert Power; Jonathan W Hooton; Ray V Rajotte; Alex Rabinovitch
Testicular sertoli cells protect islet beta-cells from autoimmune destruction in NOD mice by a transforming growth factor-beta1-dependent mechanism.
Diabetes 2000;49(11):1810-8.
2000: Gina R Rayat; B Singh; Gregory S Korbutt; Ray V Rajotte
Single injection of insulin delays the recurrence of diabetes in syngeneic islet-transplanted diabetic NOD mice.
Transplantation 2000;70(6):976-9.
2000: A M James Shapiro; Jonathan R T Lakey; Edmond A Ryan; Gregory S Korbutt; E Toth; Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.
The New England journal of medicine 2000;343(4):230-8.
2000: Gregory S Korbutt; Wilma L Suarez-Pinzon; RF Power; Ray V Rajotte; Alex Rabinovitch
Testicular Sertoli cells exert both protective and destructive effects on syngeneic islet grafts in non-obese diabetic mice.
Diabetologia 2000;43(4):474-80.
2000: Gina R Rayat; Ray V Rajotte; Ziliang Ao; Gregory S Korbutt
Microencapsulation of neonatal porcine islets: protection from human antibody/complement-mediated cytolysis in vitro and long-term reversal of diabetes in nude mice.
Transplantation 2000;69(6):1084-90.
1999: Ray V Rajotte
Islet cryopreservation protocols.
Annals of the New York Academy of Sciences 1999;875():200-7.
1999: Gina R Rayat; Ray V Rajotte; Gregory S Korbutt
Potential application of neonatal porcine islets as treatment for type 1 diabetes: a review.
Annals of the New York Academy of Sciences 1999;875():175-88.
1999: Alex Rabinovitch; Wilma L Suarez-Pinzon; Ken Strynadka; Qida Ju; Diane Edelstein; Michael Brownlee; Gregory S Korbutt; Ray V Rajotte
Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.
Diabetes 1999;48(6):1223-9.
1999: Jonathan R T Lakey; Garth L Warnock; A M James Shapiro; Gregory S Korbutt; Ziliang Ao; Norman M Kneteman; Ray V Rajotte
Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion.
Cell transplantation 1999;8(3):285-92.
1999: Wilma L Suarez-Pinzon; O Sorensen; R Chris Bleackley; John Elliott; Ray V Rajotte; Alex Rabinovitch
Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets.
Diabetes 1999;48(1):21-8.
1998: Gina R Rayat; Ray V Rajotte; John Elliott; Gregory S Korbutt
Expression of Gal alpha(1,3)gal on neonatal porcine islet beta-cells and susceptibility to human antibody/complement lysis.
Diabetes 1998;47(9):1406-11.
1998: Anita Gainer; Wilma L Suarez-Pinzon; W P Min; J R Swiston; C Hancock-Friesen; Gregory S Korbutt; Ray V Rajotte; Garth L Warnock; John Elliott
Improved survival of biolistically transfected mouse islet allografts expressing CTLA4-Ig or soluble Fas ligand.
Transplantation 1998;66(2):194-9.
1998: M S Cattral; Jonathan R T Lakey; Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Effect of cryopreservation on the survival and function of murine islet isografts and allografts.
Cell transplantation 1998;7(4):373-9.
1998: K S Rønningen; Alexey Atrazhev; L Luo; C Luo; D K Smith; Gregory S Korbutt; Ray V Rajotte; John Elliott
Anti-BSA antibodies do not cross-react with the 69-kDa islet cell autoantigen ICA69.
Journal of autoimmunity 1998;11(3):223-31.
1998: Wilma L Suarez-Pinzon; Gregory S Korbutt; Gina R Rayat; O Sorensen; RF Power; Ray V Rajotte; Alex Rabinovitch
Neonatal porcine islet xenografts in nonobese diabetic mice: effects on blood glucose and analysis of cytokines expressed in the islet grafts.
Transplantation proceedings 1998;30(2):654-5.
1998: A M James Shapiro; Er Geng Hao; Jonathan R T Lakey; John Elliott; Ray V Rajotte; Norman M Kneteman
Development of diagnostic markers for islet allograft rejection.
Transplantation proceedings 1998;30(2):647.
1998: A M James Shapiro; Heather L Gallant; Er Geng Hao; J Wong; Ray V Rajotte; Randall W Yatscoff; Norman M Kneteman
Portal vein immunosuppressant levels and islet graft toxicity.
Transplantation proceedings 1998;30(2):641.
1998: Anita Gainer; Wilma L Suarez-Pinzon; W P Min; C Hancock-Friesen; Gregory S Korbutt; Ray V Rajotte; Alex Rabinovitch; Garth L Warnock; John Elliott
Prolongation of allograft survival of transfected islets expressing human CTLA4-Ig, human soluble Fas ligand or a combination of the two.
Transplantation proceedings 1998;30(2):534.
1998: A M James Shapiro; Er Geng Hao; Jonathan R T Lakey; Diane T Finegood; Ray V Rajotte; Norman M Kneteman
Diabetogenic synergism in canine islet autografts from cyclosporine and steroids in combination.
Transplantation proceedings 1998;30(2):527.
1998: Ziliang Ao; Wilma L Suarez-Pinzon; Ray V Rajotte; Gregory S Korbutt; M Flashner; Alex Rabinovitch
Transplantation of microencapsulated syngeneic and xenogeneic (neonatal porcine) islets in nonobese diabetic mice.
Transplantation proceedings 1998;30(2):500.
1998: Gregory S Korbutt; Ziliang Ao; M Flashner; John Elliott; Ray V Rajotte
Coencapsulation of allogeneic islets with allogeneic Sertoli cells prolongs graft survival without systemic immunosuppression.
Transplantation proceedings 1998;30(2):419.
1998: Jonathan R T Lakey; Garth L Warnock; Ziliang Ao; A M James Shapiro; Gregory S Korbutt; Norman M Kneteman; Ray V Rajotte
Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion.
Transplantation proceedings 1998;30(2):359.
1998: Gina R Rayat; Ray V Rajotte; John Elliott; Gregory S Korbutt
Gal alpha(1,3)Gal expression on neonatal porcine islet cells and susceptibility to human antibody/complement lysis.
Transplantation proceedings 1998;30(2):325.
1997: Gregory S Korbutt; Ziliang Ao; M Flashner; Ray V Rajotte
Neonatal porcine islets as a possible source of tissue for humans and microencapsulation improves the metabolic response of islet graft posttransplantation.
Annals of the New York Academy of Sciences 1997;831():294-303.
1997: Alex Rabinovitch; Wilma L Suarez-Pinzon; O Sorensen; Ray V Rajotte; RF Power
TNF-alpha down-regulates type 1 cytokines and prolongs survival of syngeneic islet grafts in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6298-303.
1997: Alex Rabinovitch; Wilma L Suarez-Pinzon; O Sorensen; Ray V Rajotte; RF Power
Combination therapy with cyclosporine and interleukin-4 or interleukin-10 prolongs survival of synergeneic pancreatic islet grafts in nonobese diabetic mice: islet graft survival does not correlate with mRNA levels of type 1 or type 2 cytokines, or transforming growth factor-beta in the islet grafts.
Transplantation 1997;64(11):1525-31.
1997: Gina R Rayat; Gregory S Korbutt; John Elliott; Ray V Rajotte
Survival and function of syngeneic rat islet grafts placed within the thymus versus under the kidney capsule.
Cell transplantation 1997;6(6):597-602.
1997: Gregory S Korbutt; Gina R Rayat; Justin A Ezekowitz; Ray V Rajotte
Cryopreservation of rat pancreatic islets: effect of ethylene glycol on islet function and cellular composition.
Transplantation 1997;64(7):1065-70.
1997: D K Smith; Gregory S Korbutt; Wilma L Suarez-Pinzon; Daniel J Kao; Ray V Rajotte; John Elliott
Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent beta cell destruction in diabetic NOD mice.
Transplantation 1997;64(7):1040-9.
1997: RA Reimer; Alan B R Thomson; Ray V Rajotte; Tapan K Basu; Buncha Ooraikul; Mike I McBurney
A physiological level of rhubarb fiber increases proglucagon gene expression and modulates intestinal glucose uptake in rats.
The Journal of nutrition 1997;127(10):1923-8.
1997: Collin J Weber; M K Hagler; J T Chryssochoos; Judith A Kapp; Gregory S Korbutt; Ray V Rajotte; Peter Linsley
CTLA4-Ig prolongs survival of microencapsulated neonatal porcine islet xenografts in diabetic NOD mice.
Cell transplantation 1997;6(5):505-8.
1997: Gregory S Korbutt; John Elliott; Ziliang Ao; M Flashner; Garth L Warnock; Ray V Rajotte
Microencapsulation of neonatal porcine islets: long-term reversal of diabetes in nude mice and in vitro protection from human complement mediated cytolysis.
Transplantation proceedings 1997;29(4):2128.
1997: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte
Optimization of removal of cryoprotectant from frozen-thawed islets.
Transplantation proceedings 1997;29(4):1986.
1997: Gregory S Korbutt; Justin A Ezekowitz; M M Rajotte; Gina R Rayat; Ray V Rajotte
Successful cryopreservation of rat islets using ethylene glycol.
Transplantation proceedings 1997;29(4):1983.
1997: Jonathan R T Lakey; Garth L Warnock; M Brierton; Ziliang Ao; B J Hering; N London; Camillo Ricordi; F Corbin; Ray V Rajotte
Development of an automated computer-controlled islet isolation system.
Transplantation proceedings 1997;29(4):1956.
1997: Anita Gainer; Gregory S Korbutt; Ray V Rajotte; Garth L Warnock; John Elliott
Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet allograft survival.
Transplantation 1997;63(7):1017-21.
1997: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte
Comparison of methods used for the removal of DMSO following cryopreservation and the development of an automated protocol.
Cell transplantation 1997;6(2):163-72.
1997: Gregory S Korbutt; John Elliott; Ray V Rajotte
Cotransplantation of allogeneic islets with allogeneic testicular cell aggregates allows long-term graft survival without systemic immunosuppression.
Diabetes 1997;46(2):317-22.
1997: Gregory S Korbutt; G L Warlock; Ray V Rajotte
Islet transplantation.
Advances in experimental medicine and biology 1997;426():397-410.
1997: Jonathan R T Lakey; Garth L Warnock; M Brierton; Ziliang Ao; B J Hering; N J London; Camillo Ricordi; F Corbin; Ray V Rajotte
Development of an automated computer-controlled islet isolation system.
Cell transplantation 1997;6(1):47-57.
1996: A M James Shapiro; Er Geng Hao; Ray V Rajotte; Norman M Kneteman
High yield of rodent islets with intraductal collagenase and stationary digestion--a comparison with standard technique.
Cell transplantation 1996;5(6):631-8.
1996: Wilma L Suarez-Pinzon; Ray V Rajotte; T R Mosmann; Alex Rabinovitch
Both CD4+ and CD8+ T-cells in syngeneic islet grafts in NOD mice produce interferon-gamma during beta-cell destruction.
Diabetes 1996;45(10):1350-7.
1996: Alex Rabinovitch; Wilma L Suarez-Pinzon; K Strynadka; J R Lakey; Ray V Rajotte
Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production.
The Journal of clinical endocrinology and metabolism 1996;81(9):3197-202.
1996: Anita Gainer; Gregory S Korbutt; Ray V Rajotte; Garth L Warnock; John Elliott
Successful biolistic transformation of mouse pancreatic islets while preserving cellular function.
Transplantation 1996;61(11):1567-71.
1996: Jonathan R T Lakey; Garth L Warnock; Ziliang Ao; Ray V Rajotte
Bulk cryopreservation of isolated islets of Langerhans.
Cell transplantation 1996;5(3):395-404.
1996: Gregory S Korbutt; John Elliott; Ziliang Ao; D K Smith; Garth L Warnock; Ray V Rajotte
Large scale isolation, growth, and function of porcine neonatal islet cells.
The Journal of clinical investigation 1996;97(9):2119-29.
1996: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte; M E Suarez-Alamazor; Ziliang Ao; A M James Shapiro; Norman M Kneteman
Variables in organ donors that affect the recovery of human islets of Langerhans.
Transplantation 1996;61(7):1047-53.
1996: P J Tuitoek; S Ziari; Andrew T C Tsin; Ray V Rajotte; M Suh; Tapan K Basu
Streptozotocin-induced diabetes in rats is associated with impaired metabolic availability of vitamin A (retinol).
The British journal of nutrition 1996;75(4):615-22.
1996: Gregory S Korbutt; Launa Aspeslet; Ziliang Ao; Garth L Warnock; Justin A Ezekowitz; Arvind Koshal; Ray V Rajotte; Randall W Yatscoff
Porcine islet cell antigens are recognized by xenoreactive natural human antibodies of both IgG and IgM subtypes.
Transplantation proceedings 1996;28(2):837-8.
1996: Jonathan R T Lakey; Randall W Yatscoff; Arvind Koshal; Ray V Rajotte
Prolongation of concordant islet xenografts with leflunomide.
Transplantation proceedings 1996;28(2):816.
1996: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte
Intrathymic transplantation of fresh and cryopreserved islets for the induction of a state of unresponsiveness in rats.
Transplantation 1996;61(3):506-8.
1996: A M James Shapiro; Er Geng Hao; Ray V Rajotte; Norman M Kneteman
Impact of Lazaroid U74006F on ischemia and reperfusion injury of islets after transplantation in the rat.
Transplantation proceedings 1996;28(1):85-6.
1996: P J Tuitoek; Jonathan R T Lakey; Ray V Rajotte; Tapan K Basu
Strain variation in vitamin A (retinol) status of streptozotocin-induced diabetic rats.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 1996;66(2):101-5.
1995: Gregory S Korbutt; D K Smith; Ray V Rajotte; John Elliott
Expression of beta-galactosidase in mouse pancreatic islets by adenoviral-mediated gene transfer.
Transplantation proceedings 1995;27(6):3414.
1995: Jonathan R T Lakey; Bhagirath Singh; Garth L Warnock; John Elliott; Ray V Rajotte
Dose dependence of bacillus Calmette-Guerin on the prevention of autoimmune diabetes in syngeneic islet transplantation.
Transplantation proceedings 1995;27(6):3413.
1995: Ray V Rajotte; Ziliang Ao; Gregory S Korbutt; Jonathan R T Lakey; M Flashner; C B Colby; Garth L Warnock
Cryopreservation of microencapsulated canine islets.
Transplantation proceedings 1995;27(6):3389.
1995: A M James Shapiro; Er Geng Hao; Ray V Rajotte; Norman M Kneteman
Stationary digestion after intraductal collagenase improves islet recovery in the rat.
Transplantation proceedings 1995;27(6):3378.
1995: Ziliang Ao; Gregory S Korbutt; Garth L Warnock; M Flashner; C B Colby; Ray V Rajotte
Microencapsulation enhances canine islet survival during long-term culture.
Transplantation proceedings 1995;27(6):3350.
1995: Ziliang Ao; Gregory S Korbutt; Garth L Warnock; M Flashner; C B Colby; K L Luskey; Ray V Rajotte
Microencapsulation improves canine islet survival in vivo.
Transplantation proceedings 1995;27(6):3349.
1995: M S Cattral; Jonathan R T Lakey; Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Effect of cryopreservation on islet recovery and in vivo function.
Transplantation proceedings 1995;27(6):3336.
1995: Anita Gainer; Gregory S Korbutt; Ray V Rajotte; Garth L Warnock; John Elliott
Biolistic transformation of pancreatic islets.
Transplantation proceedings 1995;27(6):3278.
1995: Gregory S Korbutt; Ziliang Ao; Garth L Warnock; Ray V Rajotte
Large-scale isolation of viable porcine neonatal islet cell (NIC) aggregates.
Transplantation proceedings 1995;27(6):3267.
1995: Jonathan R T Lakey; Ziliang Ao; Garth L Warnock; Gregory S Korbutt; M Flashner; C B Colby; Ray V Rajotte
Recovery and in vivo function of canine islets cryopreserved in a freezer bag.
Transplantation proceedings 1995;27(6):3266.
1995: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte; Ziliang Ao; M E Suarez-Almazor; A M James Shapiro; Norman M Kneteman
Factors in cadaveric donors that affect recovery of human islets of Langerhans.
Transplantation proceedings 1995;27(6):3265.
1995: Gregory S Korbutt; Ziliang Ao; Garth L Warnock; M Flashner; Ray V Rajotte
Successful reversal of diabetes in nude mice by transplantation of microencapsulated porcine neonatal islet cell aggregates.
Transplantation proceedings 1995;27(6):3212.
1995: G I Warnock; P Tsapogas; Edmond A Ryan; Jonathan R T Lakey; Gregory S Korbutt; Norman M Kneteman; Ziliang Ao; Alex Rabinovitch; Ray V Rajotte
Natural history of insulin independence after transplantation of multidonor cryopreserved pancreatic islets in type 1 diabetic humans.
Transplantation proceedings 1995;27(6):3159-60.
1995: Alex Rabinovitch; Wilma L Suarez-Pinzon; O Sorensen; R Chris Bleackley; RF Power; Ray V Rajotte
Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice. Analysis of cytokine mRNA expression in the graft.
Transplantation 1995;60(4):368-74.
1995: Jonathan R T Lakey; Bhagirath Singh; Garth L Warnock; John Elliott; Ray V Rajotte
Long-term survival of syngeneic islet grafts in BCG-treated diabetic NOD mice can be reversed by cyclophosphamide.
Transplantation 1995;59(12):1751-3.
1995: Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock
Microbial surveillance of human islet isolation, in vitro culture, and cryopreservation.
Clinical and investigative medicine. Médecine clinique et experimentale 1995;18(3):168-76.
1995: M Thomas Clandinin; Lawrence C H Wang; Ray V Rajotte; Margaret A French; Yeow K Goh; E S Kielo
Increasing the dietary polyunsaturated fat content alters whole-body utilization of 16:0 and 10:0.
The American journal of clinical nutrition 1995;61(5):1052-7.
1995: A M James Shapiro; Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock; M S Friedlich; L D Jewell; Norman M Kneteman
Portal vein thrombosis after transplantation of partially purified pancreatic islets in a combined human liver/islet allograft.
Transplantation 1995;59(7):1060-3.
1995: Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock; Norman M Kneteman
Human pancreas preservation prior to islet isolation. Cold ischemic tolerance.
Transplantation 1995;59(5):689-94.
1994: Anita Gainer; Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock
Survival and function of human islets subjected to gamma-radiation.
Transplantation proceedings 1994;26(6):3457.
1994: Garth L Warnock; Jonathan R T Lakey; Ziliang Ao; Ray V Rajotte
Tissue banking of cryopreserved islets for clinical islet transplantation.
Transplantation proceedings 1994;26(6):3438.
1994: Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock; Norman M Kneteman
Cold ischemic tolerance of human pancreas: assessment of islet recovery and in vitro function.
Transplantation proceedings 1994;26(6):3416.
1994: Jonathan R T Lakey; Garth L Warnock; Ray V Rajotte
Conditions for the induction of unresponsiveness to cryopreserved islet allografts with intrathymic islets.
Transplantation proceedings 1994;26(6):3313.
1994: Jonathan R T Lakey; Garth L Warnock; Norman M Kneteman; Ziliang Ao; Ray V Rajotte
Development of a method for bulk cryopreservation of purified canine islets.
Transplantation proceedings 1994;26(6):3300.
1994: Norman M Kneteman; Jonathan R T Lakey; T A Kizilisik; Ziliang Ao; Garth L Warnock; Ray V Rajotte
Cadaver pancreas recovery technique. Impact on islet recovery and in vitro function.
Transplantation 1994;58(10):1114-9.
1994: F Moussy; S Jakeway; D Jed Harrison; Ray V Rajotte
In vitro and in vivo performance and lifetime of perfluorinated ionomer-coated glucose sensors after high-temperature curing.
Analytical chemistry 1994;66(22):3882-8.
1994: Alex Rabinovitch; Wilma L Suarez-Pinzon; K Strynadka; Richard Schulz; J R Lakey; Garth Warnock; Ray V Rajotte
Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production.
The Journal of clinical endocrinology and metabolism 1994;79(4):1058-62.
1994: Darryl W O'Brien; G D Molnar; D C O'Brien; Ray V Rajotte
Portal vein insulin flux and arterial glucose fluctuations in response to an oral meal test in islet cell-transplanted dogs.
Pancreas 1994;9(5):543-9.
1994: Alex Rabinovitch; O Sorensen; Wilma L Suarez-Pinzon; RF Power; Ray V Rajotte; R Chris Bleackley
Analysis of cytokine mRNA expression in syngeneic islet grafts of NOD mice: interleukin 2 and interferon gamma mRNA expression correlate with graft rejection and interleukin 10 with graft survival.
Diabetologia 1994;37(8):833-7.
1994: Jonathan R T Lakey; Bhagirath Singh; Garth L Warnock; Ray V Rajotte
BCG immunotherapy prevents recurrence of diabetes in islet grafts transplanted into spontaneously diabetic NOD mice.
Transplantation 1994;57(8):1213-7.
1994: Jonathan R T Lakey; Ray V Rajotte; Geoffrey D Taylor; T Kirkland; Garth L Warnock
Microbial studies of a tissue bank of cryopreserved human islet cells.
Transplantation proceedings 1994;26(2):827.
1994: Jonathan R T Lakey; Garth L Warnock; Norman M Kneteman; Ziliang Ao; Ray V Rajotte
Effects of pre-cryopreservation culture on human islet recovery and in vitro function.
Transplantation proceedings 1994;26(2):820.
1994: Jonathan R T Lakey; Garth L Warnock; Bhagirath Singh; Ray V Rajotte
Adjuvant immunotherapy with Bacillus Calmette-Guerin prevents recurrence of diabetes in islet grafts transplanted into NOD mice.
Transplantation proceedings 1994;26(2):736.
1994: Ray V Rajotte; V M Tighe; Garth L Warnock; Norman M Kneteman; Diane T Finegood
New site for islet transplantation in rats--liver-mesentery or liver-omental pouch.
Transplantation proceedings 1994;26(2):675.
1994: Darryl W O'Brien; G D Molnar; Ray V Rajotte
Reduced insulin response from transplanted islet cells impairs regulation of hepatic glucose output.
Transplantation proceedings 1994;26(2):666.
1994: Jonathan R T Lakey; T A Kizilisik; Ray V Rajotte; Ziliang Ao; Garth L Warnock; Norman M Kneteman
Prospective evaluation of two techniques for human pancreas recovery before islet isolation.
Transplantation proceedings 1994;26(2):589.
1994: Ray V Rajotte
Cryopreservation of pancreatic islets.
Transplantation proceedings 1994;26(2):395-6.
1994: A J Portis; Ray V Rajotte; Teresa L Krukoff
Reinnervation of isolated islets of Langerhans transplanted beneath the kidney capsule in the rat.
Cell transplantation 1994;3(2):163-70.
1994: F Moussy; D Jed Harrison; Ray V Rajotte
A miniaturized Nafion-based glucose sensor: in vitro and in vivo evaluation in dogs.
The International journal of artificial organs 1994;17(2):88-94.
1994: Garth L Warnock; K D Dabbs; M S Cattral; Ray V Rajotte
Improved survival of in vitro cultured canine islet allografts.
Transplantation 1994;57(1):17-22.
1994: Geoffrey D Taylor; T Kirkland; J Lakey; Ray V Rajotte; Garth L Warnock
Bacteremia due to transplantation of contaminated cryopreserved pancreatic islets.
Cell transplantation 1994;3(1):103-6.
1994: P J Tuitoek; Alan B R Thomson; Ray V Rajotte; Tapan K Basu
Intestinal absorption of vitamin A in streptozotocin-induced diabetic rats.
Diabetes research (Edinburgh, Scotland) 1994;25(4):151-8.
1993: W J Yakimets; Jonathan R T Lakey; Randall W Yatscoff; D Katyal; Ziliang Ao; Diane T Finegood; Ray V Rajotte; Norman M Kneteman
Prolongation of canine pancreatic islet allograft survival with combined rapamycin and cyclosporine therapy at low doses. Rapamycin efficacy is blood level related.
Transplantation 1993;56(6):1293-8.
1993: Gary D Lopaschuk; Jonathan R T Lakey; R Barr; Richard B Wambolt; Alan B R Thomson; M Thomas Clandinin; Ray V Rajotte
Islet transplantation improves glucose oxidation and mechanical function in diabetic rat hearts.
Canadian journal of physiology and pharmacology 1993;71(12):896-903.
1993: M C Fabian; Jonathan R T Lakey; Ray V Rajotte; Norman M Kneteman
The efficacy and toxicity of rapamycin in murine islet transplantation. In vitro and in vivo studies.
Transplantation 1993;56(5):1137-42.
1993: Ziliang Ao; K Matayoshi; Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock
Survival and function of purified islets in the omental pouch site of outbred dogs.
Transplantation 1993;56(3):524-9.
1993: F Moussy; D Jed Harrison; Darryl W O'Brien; Ray V Rajotte
Performance of subcutaneously implanted needle-type glucose sensors employing a novel trilayer coating.
Analytical chemistry 1993;65(15):2072-7.
1993: Jonathan R T Lakey; Garth L Warnock; R E Seelis; Ziliang Ao; Norman M Kneteman; Ray V Rajotte
Human islet purification with discontinuous density gradients following cold storage of the pancreas.
Transplantation proceedings 1993;25(1 Pt 2):957-8.
1993: M S Cattral; Garth L Warnock; Norman M Kneteman; Philip F Halloran; Ray V Rajotte
The effect of cryopreservation on the survival and MHC antigen expression of murine islet allografts.
Transplantation 1993;55(1):159-63.
1993: Alan B R Thomson; Monika Keelan; T Lam; Ray V Rajotte; M L Garg; M Thomas Clandinin
Fish oil modifies effect of high cholesterol diet on intestinal absorption in diabetic rats.
Diabetes research (Edinburgh, Scotland) 1993;22(4):171-83.
1992: Garth L Warnock; Edmond A Ryan; Norman M Kneteman; Ziliang Ao; Jonathan R T Lakey; Ray V Rajotte
The natural history of transplantation of insulin-producing pancreatic islets into type I diabetic patients.
Transplantation proceedings 1992;24(6):3058.
1992: Jonathan R T Lakey; T Wang; Garth L Warnock; Bhagirath Singh; Ray V Rajotte
Prevention of recurrence of insulin-dependent diabetes mellitus in islet cell-transplanted diabetic NOD mice using adjuvant therapy.
Transplantation proceedings 1992;24(6):2848.
1992: M C Fabian; Jonathan R T Lakey; Ray V Rajotte; Norman M Kneteman
Rapamycin prolongs murine islet allograft survival.
Transplantation proceedings 1992;24(6):2842.
1992: Jonathan R T Lakey; Garth L Warnock; R E Seelis; Ziliang Ao; Norman M Kneteman; Ray V Rajotte
A comparison of human islet purification with discontinuous density gradients of Ficoll prepared with Euro-Collins or medium 199 solution.
Transplantation proceedings 1992;24(6):2825.
1992: Ziliang Ao; K Matayoshi; W J Yakimets; D Katyal; Ray V Rajotte; Garth L Warnock
Development of an omental pouch site for islet transplantation.
Transplantation proceedings 1992;24(6):2789.
1992: Ziliang Ao; Jonathan R T Lakey; Ray V Rajotte; Garth L Warnock
Collagenase digestion of canine pancreas by gentle automated dissociation in combination with ductal perfusion optimizes mass recovery of islets.
Transplantation proceedings 1992;24(6):2787.
1992: Ziliang Ao; K Matayoshi; W J Yakimets; Jonathan R T Lakey; D Katyal; Ray V Rajotte; Garth L Warnock
Comparison of dextran and Ficoll density gradients for purification of canine islets.
Transplantation proceedings 1992;24(6):2788.
1992: B W Tobin; J T Lewis; B L Tobin; Ray V Rajotte; Diane T Finegood
Markedly reduced beta-cell function does not result in insulin resistance in islet autografted dogs.
Diabetes 1992;41(9):1172-81.
1992: T Wang; Bhagirath Singh; Garth L Warnock; Ray V Rajotte
Prevention of recurrence of IDDM in islet-transplanted diabetic NOD mice by adjuvant immunotherapy.
Diabetes 1992;41(1):114-7.
1992: Garth L Warnock; Norman M Kneteman; Edmond A Ryan; Alex Rabinovitch; Ray V Rajotte
Long-term follow-up after transplantation of insulin-producing pancreatic islets into patients with type 1 (insulin-dependent) diabetes mellitus.
Diabetologia 1992;35(1):89-95.
1992: Jonathan R T Lakey; Alan B R Thomson; Monika Keelan; G L Lopaschuk; M Thomas Clandinin; C I Cheeseman; Ray V Rajotte
Dietary lipid content influences the clinical and intestinal adaptive responses to islet transplantation in diabetic rats.
Diabetes research (Edinburgh, Scotland) 1992;19(4):149-64.
1991: M S Cattral; Garth L Warnock; M G Evans; Ray V Rajotte
Transplantation of purified frozen/thawed canine pancreatic islet allografts with cyclosporine.
Transplantation 1991;52(3):457-61.
1991: J T Venkatraman; Daniel J Pehowich; Bhagirath Singh; Ray V Rajotte; Alan B R Thomson; M Thomas Clandinin
Effect of dietary fat on diabetes-induced changes in liver microsomal fatty acid composition and glucose-6-phosphatase activity in rats.
Lipids 1991;26(6):441-4.
1991: Jonathan R T Lakey; Lawrence C H Wang; Ray V Rajotte
Optimal temperature in short-term hypothermic preservation of rat pancreas.
Transplantation 1991;51(5):977-81.
1991: R F Turner; D Jed Harrison; Ray V Rajotte
Preliminary in vivo biocompatibility studies on perfluorosulphonic acid polymer membranes for biosensor applications.
Biomaterials 1991;12(4):361-8.
1991: Darryl W O'Brien; H A Semple; G D Molnar; Y Tam; Ronald T Coutts; Ray V Rajotte; J Bayens-Simmonds
A chronic conscious dog model for direct transhepatic studies in normal and pancreatic islet cell transplanted dogs.
Journal of pharmacological methods 1991;25(2):157-70.
1991: Monika Keelan; Alan B R Thomson; A A Wierzbicki; E Wierzbicki; Ray V Rajotte; M Thomas Clandinin
Isocaloric modification of dietary lipids influences intestinal brush border membrane composition in diabetic rats.
Diabetes research (Edinburgh, Scotland) 1991;16(3):127-38.
1991: Garth L Warnock; R E Seelis; Norman M Kneteman; Ray V Rajotte
Studies of the isolation and transplantation of purified islets in adult humans.
Transplantation proceedings 1991;23(1 Pt 1):787-8.
1991: K D Dabbs; Garth L Warnock; M S Cattral; Ray V Rajotte
Reduced immunosuppression for in vitro cultured, pure canine islets transplanted from single donors.
Transplantation proceedings 1991;23(1 Pt 1):781-2.
1991: M S Cattral; Garth L Warnock; R E Seelis; Ray V Rajotte
Mass isolation of highly purified islets from the canine pancreas.
Transplantation proceedings 1991;23(1 Pt 1):779-80.
1991: M S Cattral; Garth L Warnock; M G Evans; Ray V Rajotte
Transplantation of purified single-donor cryopreserved canine islet allografts with cyclosporine.
Transplantation proceedings 1991;23(1 Pt 1):777-8.
1991: Garth L Warnock; Norman M Kneteman; E Ryan; R E Seelis; Alex Rabinovitch; Ray V Rajotte
Normoglycaemia after transplantation of freshly isolated and cryopreserved pancreatic islets in type 1 (insulin-dependent) diabetes mellitus.
Diabetologia 1991;34(1):55-8.
1990: S Churnratanakul; K L Kirdeikis; G K Murphy; B J Wirzba; Monika Keelan; Ray V Rajotte; M Thomas Clandinin; Alan B R Thomson
Dietary omega-3 fatty acids partially correct the enhanced in vivo uptake of glucose in diabetic rats.
Diabetes research (Edinburgh, Scotland) 1990;15(3):117-23.
1990: Darryl W O'Brien; G D Molnar; T D Petersen; Ray V Rajotte
The effect of somatostatin on insulin and glucose levels during insulin infusion in anesthetized dogs.
Pancreas 1990;5(6):652-7.
1990: Garth L Warnock; Norman M Kneteman; M G Evans; K D Dabbs; Ray V Rajotte
Comparison of automated and manual methods for islet isolation.
Canadian journal of surgery. Journal canadien de chirurgie 1990;33(5):368-71.
1990: Alan B R Thomson; Monika Keelan; Ray V Rajotte; T Cheng; Richard N Fedorak; C Cheeseman; M Thomas Clandinin
Long-term effects of manipulations of dietary omega-3 fatty acids on clinical control and in vitro uptake of glucose and lipids in diabetic rats.
Diabetes research (Edinburgh, Scotland) 1990;15(2):85-93.
1990: A J Portis; Garth L Warnock; Diane T Finegood; AN Belcastro; Ray V Rajotte
Glucoregulatory response to moderate exercise in long-term islet cell autografted dogs.
Canadian journal of physiology and pharmacology 1990;68(10):1308-12.
1990: Monika Keelan; A A Wierzbicki; M Thomas Clandinin; K Walker; Ray V Rajotte; Alan B R Thomson
Dietary fat saturation alters diabetic rat brush border membrane phospholipid fatty acid composition.
Diabetes research (Edinburgh, Scotland) 1990;14(4):159-64.
1990: M G Evans; Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Reversal of diabetes in dogs by transplantation of pure cryopreserved islets.
Transplantation 1990;50(2):202-6.
1990: Alex Rabinovitch; W Sumoski; Ray V Rajotte; Garth Warnock
Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture.
The Journal of clinical endocrinology and metabolism 1990;71(1):152-6.
1990: Norman M Kneteman; T J DeGroot; Garth L Warnock; Ray V Rajotte
Islet recovery from rat pancreas is altered by procurement technique and flush solution.
Transplantation proceedings 1990;22(2):779.
1990: Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Effect of diabetes on the function of transplanted human islets of Langerhans.
Transplantation proceedings 1990;22(2):804-5.
1990: Norman M Kneteman; Garth L Warnock; M G Evans; I Dawidson; Ray V Rajotte
Islet isolation from human pancreas stored in UW solution for 6 to 26 hours.
Transplantation proceedings 1990;22(2):763-4.
1990: M G Evans; Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Reversal of diabetes by transplantation of pure cryopreserved canine islets.
Transplantation proceedings 1990;22(2):543-4.
1990: Norman M Kneteman; T J DeGroot; Garth L Warnock; Ray V Rajotte
Pancreas preservation prior to islet isolation: evaluation of storage solutions in a rodent model.
Transplantation proceedings 1990;22(2):541-2.
1990: Norman M Kneteman; Garth L Warnock; M G Evans; R W Nason; Ray V Rajotte
Prolonged function of canine pancreatic fragments autotransplanted to the spleen by venous reflux.
Transplantation 1990;49(4):679-81.
1990: Ray V Rajotte; M G Evans; Garth L Warnock; Norman M Kneteman
Islet cryopreservation.
Hormone and metabolic research. Supplement series 1990;25():72-81.
1990: Norman M Kneteman; T J DeGroot; Garth L Warnock; Ray V Rajotte
The evaluation of solutions for pancreas preservation prior to islet isolation.
Hormone and metabolic research. Supplement series 1990;25():4-9.
1990: Norman M Kneteman; M C Cattral; Garth L Warnock; D W Scharp; J L Jaspan; Ray V Rajotte
Immunosuppression and pancreatic islet transplantation.
Hormone and metabolic research. Supplement series 1990;25():193-9.
1990: Garth L Warnock; K D Dabbs; M G Evans; M S Cattral; Norman M Kneteman; Ray V Rajotte
Critical mass of islets that function after implantation in a large mammalian.
Hormone and metabolic research. Supplement series 1990;25():156-61.
1990: Garth L Warnock; Norman M Kneteman; M G Evans; Ray V Rajotte
Isolation of purified large mammal and human islets of Langerhans.
Hormone and metabolic research. Supplement series 1990;25():37-44.
1989: Garth L Warnock; Norman M Kneteman; E A Ryan; M G Evans; R E Seelis; Philip F Halloran; Alex Rabinovitch; Ray V Rajotte
Continued function of pancreatic islets after transplantation in type I diabetes.
Lancet 1989;2(8662):570-2.
1989: Chulani Kappagoda; L Jayakody; Ray V Rajotte; Alan B R Thomson; M P Senaratne
Endothelium-dependent relaxation to acetylcholine in the aorta of streptozotocin induced diabetic-rat and the BB-diabetic rat.
Clinical and investigative medicine. Médecine clinique et experimentale 1989;12(3):187-93.
1989: Garth L Warnock; M S Cattral; M G Evans; Norman M Kneteman; Ray V Rajotte
Mass isolation of pure canine islets.
Transplantation proceedings 1989;21(2):3371-2.
1989: M G Evans; Ray V Rajotte; Garth L Warnock; Norman M Kneteman
Viability studies on cryopreserved isolated canine islets of Langerhans.
Transplantation proceedings 1989;21(2):3368-70.
1989: Norman M Kneteman; M G Evans; M S Cattral; Garth L Warnock; Ray V Rajotte
A comparison of canine renal and islet transplantation with cyclosporine: assessment of islet immunogenicity.
Transplantation proceedings 1989;21(2):3366-7.
1989: Garth L Warnock; Ray V Rajotte
Effects of precryopreservation culture on survival of rat islets transplanted after slow cooling and rapid thawing.
Cryobiology 1989;26(2):103-11.
1989: M S Cattral; Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Transplantation of purified single-donor canine islet allografts with cyclosporine.
Transplantation 1989;47(4):583-7.
1989: Norman M Kneteman; M Evans; R Nason; Ray V Rajotte
Prolonged function of intrasplenic canine pancreatic fragment autografts.
Transplantation proceedings 1989;21(1 Pt 3):2619-20.
1989: M S Cattral; Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Transplantation of single-donor purified canine islets to the spleen or renal subcapsular space with cyclosporine immunosuppression.
Transplantation proceedings 1989;21(1 Pt 3):2695-6.
1989: Garth L Warnock; D Callahan; D K Ellis; Ray V Rajotte
Twenty-four-hour hypothermic storage of the canine pancreas before islet isolation.
Transplantation proceedings 1989;21(1 Pt 3):2646-7.
1989: Ray V Rajotte; Garth L Warnock; Norman M Kneteman; C Erickson; D K Ellis
Optimizing cryopreservation of isolated islets.
Transplantation proceedings 1989;21(1 Pt 3):2638-40.
1989: Garth L Warnock; T DeGroot; D Untch; D K Ellis; Ray V Rajotte
The natural history of pure canine islet autografts in hepatic or splenic sites.
Transplantation proceedings 1989;21(1 Pt 3):2617-8.
1989: Monika Keelan; Alan B R Thomson; M Thomas Clandinin; B Singh; Ray V Rajotte; M Garg
Improved intestinal form and function in diabetic rats fed long-term with a polyunsaturated fatty acid diet.
Diabetes research (Edinburgh, Scotland) 1989;10(1):43-7.
1989: Garth L Warnock; D K Ellis; M Cattral; D Untch; Norman M Kneteman; Ray V Rajotte
Viable purified islets of Langerhans from collagenase-perfused human pancreas.
Diabetes 1989;38 Suppl 1():136-9.
1989: M G Evans; Garth L Warnock; Ray V Rajotte
Comparison of sites for transplantation of canine pancreatic microfragments.
Diabetes research (Edinburgh, Scotland) 1989;10(1):35-41.
1989: Diane T Finegood; Garth L Warnock; Norman M Kneteman; Ray V Rajotte
Insulin sensitivity and glucose effectiveness in long-term islet-autotransplanted dogs.
Diabetes 1989;38 Suppl 1():189-91.
1988: R W Nason; Garth L Warnock; Ray V Rajotte
Portal versus systemic insulin delivery in canine pancreatic islet cell transplantation.
Transplantation proceedings 1988;20(6):1276-8.
1988: Garth L Warnock; M S Cattral; Ray V Rajotte
Normoglycemia after implantation of purified islet cells in dogs.
Canadian journal of surgery. Journal canadien de chirurgie 1988;31(6):421-6.
1988: Bhagirath Singh; J Lauzon; J Venkatraman; Alan B R Thomson; Ray V Rajotte; M Thomas Clandinin
Effect of high/low dietary linoleic acid levels on the function and fatty acid composition of T-lymphocytes of normal and diabetic rats.
Diabetes research (Edinburgh, Scotland) 1988;8(3):129-34.
1988: M G Coulombe; Garth L Warnock; Ray V Rajotte
Reversal of diabetes by transplantation of cryopreserved rat islets of Langerhans to the renal subcapsular space.
Diabetes research (Edinburgh, Scotland) 1988;8(1):9-15.
1988: Garth L Warnock; D Ellis; Ray V Rajotte; I Dawidson; S Baekkeskov; J Egebjerg
Studies of the isolation and viability of human islets of Langerhans.
Transplantation 1988;45(5):957-63.
1988: Garth L Warnock; Ray V Rajotte
Critical mass of purified islets that induce normoglycemia after implantation into dogs.
Diabetes 1988;37(4):467-70.
1988: Darryl W O'Brien; Ray V Rajotte; G D Molnar; K Toth; T D Petersen
Somatostatin increases hepatic insulin extraction.
Diabetes research (Edinburgh, Scotland) 1988;7(4):171-8.
1988: Alan B R Thomson; Monika Keelan; M Thomas Clandinin; Ray V Rajotte; Chris I Cheeseman; K Walker
Use of polyunsaturated fatty acid diet to treat the enhanced intestinal uptake of lipids in streptozotocin diabetic rats.
Clinical and investigative medicine. Médecine clinique et experimentale 1988;11(1):57-61.
1988: R W Nason; Ray V Rajotte; Garth L Warnock
Pancreatic islet cell transplantation: past, present and future.
Diabetes research (Edinburgh, Scotland) 1988;7(1):1-11.
1988: Ray V Rajotte; C L Erickson; M Thomas Clandinin; Alan B R Thomson; Bhagirath Singh
Clinical response to feeding a high polyunsaturated fat diet in normal and diabetic rats.
Diabetes research (Edinburgh, Scotland) 1988;7(1):41-7.
1987: Alan B R Thomson; Monika Keelan; M Thomas Clandinin; Ray V Rajotte; Chris I Cheeseman; K Walker
Treatment of the enhanced intestinal uptake of glucose in diabetic rats with a polyunsaturated fatty acid diet.
Biochimica et biophysica acta 1987;905(2):426-34.
1987: R Berzins; K R Wieczorek; Ray V Rajotte; G D Molnar; Yun K Tam; J R McGregor; D M Fawcett
Accuracy of C-peptide:insulin molar ratio as a measure of hepatic removal of insulin.
Diabetes research and clinical practice 1987;4(1):37-43.
1986: R Berzins; Yun K Tam; G D Molnar; Ray V Rajotte; K R Wieczorek; J R McGregor; D M Fawcett
Pharmacokinetic approach to the estimation of hepatic removal of insulin.
Pancreas 1986;1(6):544-9.
1985: Norman M Kneteman; Ray V Rajotte
Isolation and cryopreservation of human pancreatic islets.
Life support systems : the journal of the European Society for Artificial Organs 1985;3 Suppl 1():712-8.
1985: K R Wieczorek; Ray V Rajotte; G D Molnar; F Rumpel; J R McGregor; B T Lussier; D M Fawcett
Hepatic insulin retention depends on influx in both diabetic and normal dogs.
Clinical and investigative medicine. Médecine clinique et experimentale 1985;8(4):264-71.
1985: K R Wieczorek; Ray V Rajotte; G D Molnar; J R McGregor; B T Lussier; D M Fawcett
The effect of hepatic insulin influx on insulin retention: comparison of net flux and per cent extraction as indices of hepatic insulin retention.
Clinical and investigative medicine. Médecine clinique et experimentale 1985;8(4):257-63.