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Alexander Rakhmilevich

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Kory L Alderson; Megan M Elsenheimer; Stephen D Gillies; Mitchell Luangrath; Fariba Navid; Alexander L Rakhmilevich; Paul M Sondel
Enhancement of the anti-melanoma response of Hu14.18K322A by αCD40 + CpG.
Tyler J Van De Voort; Richard K Yang; Mildred A R Felder; Paul M Sondel; Alexander L Rakhmilevich
Intratumoral delivery of low doses of anti-CD40 mAb combined with monophosphoryl lipid a induces local and systemic antitumor effects in immunocompetent and T cell-deficient mice.
Alexander L Rakhmilevich; Tyler J Van De Voort; Nico van Rooijen; Richard K Yang; Mark J Baldeshwiler; Mildred A R Felder; Nicholas A Kalogriopoulos; David S Koslov; Paul M Sondel
Tumor-associated myeloid cells can be activated in vitro and in vivo to mediate antitumor effects.

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2013: Kory L Alderson; Megan M Elsenheimer; Stephen D Gillies; Mitchell Luangrath; Fariba Navid; Alexander L Rakhmilevich; Paul M Sondel
Enhancement of the anti-melanoma response of Hu14.18K322A by αCD40 + CpG.
Cancer immunology, immunotherapy : CII 2013;62(4):665-75.
2013: Tyler J Van De Voort; Richard K Yang; Mildred A R Felder; Paul M Sondel; Alexander L Rakhmilevich
Intratumoral delivery of low doses of anti-CD40 mAb combined with monophosphoryl lipid a induces local and systemic antitumor effects in immunocompetent and T cell-deficient mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2013;36(1):29-40.
2012: Alexander L Rakhmilevich; Tyler J Van De Voort; Nico van Rooijen; Richard K Yang; Mark J Baldeshwiler; Mildred A R Felder; Nicholas A Kalogriopoulos; David S Koslov; Paul M Sondel
Tumor-associated myeloid cells can be activated in vitro and in vivo to mediate antitumor effects.
Cancer immunology, immunotherapy : CII 2012;61(10):1683-97.
2012: Richard K Yang; Kory L Alderson; Jacek Gan; Stephen D Gillies; Jacquelyn A Hank; Nicholas A Kalogriopoulos; KyungMann Kim; Alexander L Rakhmilevich; Erik A Ranheim; Ralph A Reisfeld; Songwon Seo; Paul M Sondel
Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(5):2656-64.
2012: Alexander L Rakhmilevich; Kory L Alderson; Paul M Sondel
T-cell-independent antitumor effects of CD40 ligation.
International reviews of immunology 2012;31(4):267-78.
2011: Andrew J Russ; Christine M Seroogy; Paul M Sondel; Marulasiddappa Suresh; Lucy Wentworth; Kyle Xu; Alexander L Rakhmilevich; Clifford S Cho
Suppression of T-cell expansion by melanoma is exerted on resting cells.
Annals of surgical oncology 2011;18(13):3848-57.
2011: Brenda L Soto; Eric M Yanke; Soesiawati R Darjatmoko; Stephen D Gillies; Jacquelyn A Hank; KyungMann Kim; Arthur S Polans; Alexander L Rakhmilevich; Ralph A Reisfeld; Songwon Seo; Paul M Sondel
Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy.
International immunopharmacology 2011;11(11):1877-86.
2011: Brenda L Soto; Jacquelyn A Hank; Tyler J Van De Voort; Lalita Subramanian; Arthur S Polans; Alexander L Rakhmilevich; Richard K Yang; Songwong Seo; KyungMann Kim; Ralph A Reisfeld; Stephen D Gillies; Paul M Sondel
The anti-tumor effect of resveratrol alone or in combination with immunotherapy in a neuroblastoma model.
Cancer immunology, immunotherapy : CII 2011;60(5):731-8.
2011: Ilia N Buhtoiarov; Zane C Neal; Jacek Gan; Tatiana N Buhtoiarova; Manish S Patankar; Jennifer A A Gubbels; Jacquelyn A Hank; Brett Yamane; Alexander L Rakhmilevich; Ralph A Reisfeld; Stephen D Gillies; Paul M Sondel
Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting.
Journal of leukocyte biology 2011;89(4):625-38.
2011: Ilia N Buhtoiarov; Paul M Sondel; JON WIGGINTON; Tatiana N Buhtoiarova; Eric M Yanke; David A Mahvi; Alexander L Rakhmilevich
Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages.
Immunology 2011;132(2):226-39.
2011: Andrew J Russ; Marulasiddappa Suresh; Lucy Wentworth; Kyle Xu; Michael D Macklin; Justin V Meyers; Victoria Rajamanickam; Alexander L Rakhmilevich; Sheeba Alam; Clifford S Cho
Melanoma-induced suppression of tumor antigen-specific T cell expansion is comparable to suppression of global T cell expansion.
Cellular immunology 2011;271(1):104-9.
2009: Erik E Johnson; Brett H Yamane; Ilia N Buhtoiarov; Hillary D Lum; Alexander L Rakhmilevich; David M Mahvi; Stephen D Gillies; Paul M Sondel
Radiofrequency ablation combined with KS-IL2 immunocytokine (EMD 273066) results in an enhanced antitumor effect against murine colon adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(15):4875-84.
2009: Qing-Li Wu; Ilia N Buhtoiarov; Paul M Sondel; Alexander L Rakhmilevich; Erik A Ranheim
Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):6771-8.
2009: Ilia N Buhtoiarov; Alexander L Rakhmilevich; Lewis L Lanier; Erik A Ranheim; Paul M Sondel
Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):1940-53.
2008: Erik E Johnson; Hillary D Lum; Alexander L Rakhmilevich; Brian E Schmidt; Meghan Furlong; Ilia N Buhtoiarov; Jacquelyn A Hank; Andrew Raubitschek; David Colcher; Ralph A Reisfeld; Stephen D Gillies; Paul M Sondel
Intratumoral immunocytokine treatment results in enhanced antitumor effects.
Cancer immunology, immunotherapy : CII 2008;57(12):1891-902.
2008: Alexander L Rakhmilevich; Ilia N Buhtoiarov; Miroslav Malkovsky; Paul M Sondel
CD40 ligation in vivo can induce T cell independent antitumor effects even against immunogenic tumors.
Cancer immunology, immunotherapy : CII 2008;57(8):1151-60.
2007: David M Mahvi; M B Henry; Mark R Albertini; S Weber; Kenneth Meredith; Heidi Schalch; Alexander L Rakhmilevich; Jacquelyn A Hank; Paul M Sondel
Intratumoral injection of IL-12 plasmid DNA--results of a phase I/IB clinical trial.
Cancer gene therapy 2007;14(8):717-23.
2007: Ilia N Buhtoiarov; Paul M Sondel; Jens Eickhoff; Alexander L Rakhmilevich
Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides.
Immunology 2007;120(3):412-23.
2006: Hillary D Lum; Ilia N Buhtoiarov; Brian E Schmidt; Gideon Berke; Donna M Paulnock; Paul M Sondel; Alexander L Rakhmilevich
Tumoristatic effects of anti-CD40 mAb-activated macrophages involve nitric oxide and tumour necrosis factor-alpha.
Immunology 2006;118(2):261-70.
2006: Hillary D Lum; Ilia N Buhtoiarov; Brian E Schmidt; Gideon Berke; Donna M Paulnock; Paul M Sondel; Alexander L Rakhmilevich
In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophages.
Journal of leukocyte biology 2006;79(6):1181-92.
2006: Ilia N Buhtoiarov; Hillary D Lum; Gideon Berke; Paul M Sondel; Alexander L Rakhmilevich
Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):309-18.
2005: Ilia N Buhtoiarov; Hillary D Lum; Gideon Berke; Donna M Paulnock; Paul M Sondel; Alexander L Rakhmilevich
CD40 ligation activates murine macrophages via an IFN-gamma-dependent mechanism resulting in tumor cell destruction in vitro.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6013-22.
2004: Alexander L Rakhmilevich; Andrea T Hooper; Daniel J Hicklin; Paul M Sondel
Treatment of experimental breast cancer using interleukin-12 gene therapy combined with anti-vascular endothelial growth factor receptor-2 antibody.
Molecular cancer therapeutics 2004;3(8):969-76.
2004: Zane C Neal; Jeannie C Yang; Alexander L Rakhmilevich; Ilia N Buhtoiarov; Hillary E Lum; Michael Imboden; Jacquelyn A Hank; Holger N Lode; Ralph A Reisfeld; Stephen D Gillies; Paul M Sondel
Enhanced activity of hu14.18-IL2 immunocytokine against murine NXS2 neuroblastoma when combined with interleukin 2 therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(14):4839-47.
2004: Zane C Neal; Michael Imboden; Alexander L Rakhmilevich; Kyung Mann Kim; Jacquelyn A Hank; Jean Surfus; John R Dixon; Holger N Lode; Ralph A Reisfeld; Stephen D Gillies; Paul M Sondel
NXS2 murine neuroblastomas express increased levels of MHC class I antigens upon recurrence following NK-dependent immunotherapy.
Cancer immunology, immunotherapy : CII 2004;53(1):41-52.
2002: Fushun Shi; Alexander L Rakhmilevich; Charles P Heise; Katsuhisa Oshikawa; Paul M Sondel; Ning-Sun Yang; David M Mahvi
Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model.
Molecular cancer therapeutics 2002;1(11):949-57.
2001: Alexander L Rakhmilevich; Michael Imboden; Zhengling Hao; Macklin Michael; T Roberts; K M Wright; Mark R Albertini; Ning-Sun Yang; Paul M Sondel
Effective particle-mediated vaccination against mouse melanoma by coadministration of plasmid DNA encoding Gp100 and granulocyte-macrophage colony-stimulating factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):952-61.
2001: Michael Imboden; K R Murphy; Alexander L Rakhmilevich; Zane C Neal; R Xiang; Ralph A Reisfeld; Stephen D Gillies; Paul M Sondel
The level of MHC class I expression on murine adenocarcinoma can change the antitumor effector mechanism of immunocytokine therapy.
Cancer research 2001;61(4):1500-7.
2001: Katsuhisa Oshikawa; Alexander L Rakhmilevich; Fushun Shi; Paul M Sondel; N Yang; David M Mahvi
Interleukin 12 gene transfer into skin distant from the tumor site elicits antimetastatic effects equivalent to local gene transfer.
Human gene therapy 2001;12(2):149-60.
2001: J G Turner; Alexander L Rakhmilevich; Lyudmila Burdelya; Zane C Neal; Michael Imboden; Paul M Sondel; Hua Yu
Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):89-94.
2000: Alexander L Rakhmilevich; K Janssen; Zhengling Hao; Paul M Sondel; Ning-Sun Yang
Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism.
Cancer gene therapy 2000;7(6):826-38.
2000: Alexander L Rakhmilevich; Ning-Sun Yang
In vivo particle-mediated gene transfer for cancer therapy.
Methods in molecular medicine 2000;35():331-44.
1999: Katsuhisa Oshikawa; Fushun Shi; Alexander L Rakhmilevich; Paul M Sondel; David M Mahvi; Ning-Sun Yang
Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13351-6.
1999: Kari Kendra; Jacek Gan; M Ricci; Jean Surfus; A Shaker; Michael Super; J D Frost; Alexander L Rakhmilevich; Jacquelyn A Hank; Stephen D Gillies; Paul M Sondel
Pharmacokinetics and stability of the ch14.18-interleukin-2 fusion protein in mice.
Cancer immunology, immunotherapy : CII 1999;48(5):219-29.
1999: Alexander L Rakhmilevich; J G Timmins; K Janssen; E L Pohlmann; M J Sheehy; Ning-Sun Yang
Gene gun-mediated IL-12 gene therapy induces antitumor effects in the absence of toxicity: a direct comparison with systemic IL-12 protein therapy.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1999;22(2):135-44.
1999: F S Shi; S Weber; Jacek Gan; Alexander L Rakhmilevich; David M Mahvi
Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by cDNA-transfected tumor cells induces a more potent antitumor response than exogenous GM-CSF.
Cancer gene therapy 1999;6(1):81-8.
1997: Alexander L Rakhmilevich; K Janssen; J Turner; J Culp; Ning-Sun Yang
Cytokine gene therapy of cancer using gene gun technology: superior antitumor activity of interleukin-12.
Human gene therapy 1997;8(11):1303-11.
1996: Alexander L Rakhmilevich; J Turner; M J Ford; D McCabe; W H Sun; Paul M Sondel; K Grota; Ning-Sun Yang
Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6291-6.