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João Ramalho-Santos

Research Profile

Anatomy

Physiology

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Publications

TOP 3
Alexandra Amaral; João Ramalho-Santos
The male gamete is not a somatic cell--the possible meaning of varying sperm RNA levels.
Alexandra Amaral; Marta Baptista; Carla Paiva; Ana Paula Sousa; João Ramalho-Santos
Exogenous glucose improves long-standing human sperm motility, viability, and mitochondrial function.
João Ramalho-Santos
A sperm's tail: the importance of getting it right.

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All Publications

2013: Alexandra Amaral; João Ramalho-Santos
The male gamete is not a somatic cell--the possible meaning of varying sperm RNA levels.
Antioxidants & redox signaling 2013;18(2):179-80.
2011: Alexandra Amaral; Marta Baptista; Carla Paiva; Ana Paula Sousa; João Ramalho-Santos
Exogenous glucose improves long-standing human sperm motility, viability, and mitochondrial function.
Fertility and sterility 2011;96(4):848-50.
2011: João Ramalho-Santos
A sperm's tail: the importance of getting it right.
Human reproduction (Oxford, England) 2011;26(9):2590-1.
2011: João Ramalho-Santos
Human procreation in unchartered territory: new twists in ethical discussions.
Human reproduction (Oxford, England) 2011;26(6):1284-7.
2011: Sandro L Pereira; João Ramalho-Santos; Ana F Branco; Vilma A Sardão; Paulo J Oliveira; Rui A Carvalho
Metabolic remodeling during H9c2 myoblast differentiation: relevance for in vitro toxicity studies.
Cardiovascular toxicology 2011;11(2):180-90.
2011: Sandra Varum; Bennett Van Houten; Charles A Easley; Olga Momcilovic; Michelle B Moura; João Ramalho-Santos; Ana S Rodrigues; Gerald Schatten
Energy metabolism in human pluripotent stem cells and their differentiated counterparts.
PloS one 2011;6(6):e20914.
2011: Ângela S Inácio; Katia A Mesquita; Marta Baptista; João Ramalho-Santos; Winchil L C Vaz; Otilia V Vieira
In vitro surfactant structure-toxicity relationships: implications for surfactant use in sexually transmitted infection prophylaxis and contraception.
PloS one 2011;6(5):e19850.
2011: Ana Paula Sousa; Alexandra Amaral; Marta Baptista; Renata Tavares; Pedro Caballero-Campo; Pedro Caballero Peregrín; A Freitas; Artur Paiva; teresa santos; João Ramalho-Santos
Not all sperm are equal: functional mitochondria characterize a subpopulation of human sperm with better fertilization potential.
PloS one 2011;6(3):e18112.
2011: Paula C Mota; Marília Cordeiro; Susana Pereira; Paulo J Oliveira; António J Moreno; João Ramalho-Santos
Differential effects of p,p'-DDE on testis and liver mitochondria: implications for reproductive toxicology.
Reproductive toxicology (Elmsford, N.Y.) 2011;31(1):80-5.
2010: Sandra Gamboa; A S Rodrigues; L Henriques; C Batista; João Ramalho-Santos
Seasonal functional relevance of sperm characteristics in equine spermatozoa.
Theriogenology 2010;73(7):950-8.
2010: Ana Sofia Rodrigues; Beatriz Lacerda; António J M Moreno; João Ramalho-Santos
Proton leak modulation in testicular mitochondria affects reactive oxygen species production and lipid peroxidation.
Cell biochemistry and function 2010;28(3):224-31.
2010: A Amaral; João Ramalho-Santos
Assessment of mitochondrial potential: implications for the correct monitoring of human sperm function.
International journal of andrology 2010;33(1):e180-6.
2010: Paula C Mota; João Ramalho-Santos; Stefan Schlatt
Xenografting as a tool to preserve endangered species: outcomes and challenges in model systems.
Veterinary medicine international 2010;2011():.
2009: Sandra Amaral; João Ramalho-Santos
Aging, mitochondria and male reproductive function.
Current aging science 2009;2(3):165-73.
2009: Marta Baptista; João Ramalho-Santos
Spermicides, microbicides and antiviral agents: recent advances in the development of novel multi-functional compounds.
Mini reviews in medicinal chemistry 2009;9(13):1556-67.
2009: S Varum; O Momcilović; C Castro; A Ben-Yehudah; João Ramalho-Santos; Christopher S Navara
Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain.
Stem cell research 2009;3(2-3):142-56.
2009: João Ramalho-Santos; Sandra Varum; Sandra Amaral; Paula C Mota; Ana Paula Sousa; Alexandra Amaral
Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells.
Human reproduction update 2009;15(5):553-72.
2009: Alexandre Gaspar-Maia; Adi Alajem; Fanny Polesso; Rupa Sridharan; Mike J Mason; Amy Heidersbach; João Ramalho-Santos; Michael McManus; Kathrin Plath; Eran Meshorer; Miguel Ramalho-Santos
Chd1 regulates open chromatin and pluripotency of embryonic stem cells.
Nature 2009;460(7257):863-8.
2009: Sandra Gamboa; Manuel Machado-Faria; João Ramalho-Santos
Seminal traits, suitability for semen preservation and fertility in the native Portuguese horse breeds Puro Sangue Lusitano and Sorraia: Implications for stallion classification and assisted reproduction.
Animal reproduction science 2009;113(1-4):102-13.
2009: Paula Mota; Sandra Amaral; Luís Martins; Maria de Lourdes Pereira; Paulo J Oliveira; João Ramalho-Santos
Mitochondrial bioenergetics of testicular cells from the domestic cat (Felis catus)-a model for endangered species.
Reproductive toxicology (Elmsford, N.Y.) 2009;27(2):111-6.
2009: Sandra Amaral; Paula C Mota; Beatriz Lacerda; Marco Alves; Maria de Lourdes Pereira; Paulo Oliveira; João Ramalho-Santos
Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic rats.
Mitochondrion 2009;9(1):41-50.
2009: Renata S Tavares; Fátima C Martins; Paulo Oliveira; João Ramalho-Santos; Francisco P Peixoto
Parabens in male infertility-is there a mitochondrial connection?
Reproductive toxicology (Elmsford, N.Y.) 2009;27(1):1-7.
2009: Ana Paula M Sousa; Renata S Tavares; Juan Felipe Velez de la Calle; Helena Figueiredo; Vasco Almeida; teresa santos; João Ramalho-Santos
Dual use of Diff-Quik-like stains for the simultaneous evaluation of human sperm morphology and chromatin status.
Human reproduction (Oxford, England) 2009;24(1):28-36.
2008: Sandra Amaral; Paula Mota; Ana Sofia Rodrigues; Luís Martins; Paulo Oliveira; João Ramalho-Santos
Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak.
FEBS letters 2008;582(30):4191-6.
2008: Maria Inês Morte; Ana Margarida Rodrigues; Diana Soares; Ana Sofia Rodrigues; Sandra Gamboa; João Ramalho-Santos
The quantification of lipid and protein oxidation in stallion spermatozoa and seminal plasma: seasonal distinctions and correlations with DNA strand breaks, classical seminal parameters and stallion fertility.
Animal reproduction science 2008;106(1-2):36-47.
2008: Luis Gabriel Sánchez-Partida; Calvin R Simerly; João Ramalho-Santos
Freeze-dried primate sperm retains early reproductive potential after intracytoplasmic sperm injection.
Fertility and sterility 2008;89(3):742-5.
2008: Sandra Amaral; Paulo Oliveira; João Ramalho-Santos
Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species.
Current diabetes reviews 2008;4(1):46-54.
2008: Otilia V Vieira; Diego O Hartmann; Carla M P Cardoso; Daniel Oberdoerfer; Marta Baptista; Manuel A S Santos; Luis Almeida; João Ramalho-Santos; Winchil L C Vaz
Surfactants as microbicides and contraceptive agents: a systematic in vitro study.
PloS one 2008;3(8):e2913.
2007: Alexandra Amaral; João Ramalho-Santos; Justin C St John
The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm.
Human reproduction (Oxford, England) 2007;22(6):1585-96.
2007: Sandra Varum; Carla Bento; Ana Paula M Sousa; Carina S S Gomes-Santos; Paula Henriques; teresa santos; Cristina Teodósio; Artur Paiva; João Ramalho-Santos
Characterization of human sperm populations using conventional parameters, surface ubiquitination, and apoptotic markers.
Fertility and sterility 2007;87(3):572-83.
2006: Sandra Amaral; António J M Moreno; Maria S Santos; Raquel Seiça; João Ramalho-Santos
Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes.
Theriogenology 2006;66(9):2056-67.
2006: Oliveira Helena; João Loureiro; Luísa Filipe; Conceição Santos; João Ramalho-Santos; Mário Sousa; Maria de Lourdes Pereira
Flow cytometry evaluation of lead and cadmium effects on mouse spermatogenesis.
Reproductive toxicology (Elmsford, N.Y.) 2006;22(3):529-35.
2006: A P M Sousa; C S S Gomes-Santos; João Ramalho-Santos
Localization of SNAREs, NSF and Caveolin 1 in human spermatozoa: relationship with seminal parameters.
Archives of andrology 2006;52(5):347-53.
2006: Oliveira Helena; Teresa Margarida Santos; João Ramalho-Santos; Maria de Lourdes Pereira
Histopathological effects of hexavalent chronium in mouse kidney.
Bulletin of environmental contamination and toxicology 2006;76(6):977-83.
2006: Paula C Mota; João Ramalho-Santos
Comparison between different markers for sperm quality in the cat: Diff-Quik as a simple optical technique to assess changes in the DNA of feline epididymal sperm.
Theriogenology 2006;65(7):1360-75.
2006: Rhiannon E I Lloyd; Joon-Hee Lee; Ramiro Alberio; Emma J Bowles; João Ramalho-Santos; Keith Campbell; Justin C St John
Aberrant nucleo-cytoplasmic cross-talk results in donor cell mtDNA persistence in cloned embryos.
Genetics 2006;172(4):2515-27.
2006: Justin C St John; Alexandra Amaral; Emma J Bowles; João Facucho Oliveira; Rhiannon Lloyd; Mariana Freitas; Heather L Gray; Christopher S Navara; Gisela Oliveira; Gerald Schatten; Emma C Spikings; João Ramalho-Santos
The analysis of mitochondria and mitochondrial DNA in human embryonic stem cells.
Methods in molecular biology (Clifton, N.J.) 2006;331():347-74.
2005: Sandra Gamboa; João Ramalho-Santos
SNARE proteins and caveolin-1 in stallion spermatozoa: possible implications for fertility.
Theriogenology 2005;64(2):275-91.
2005: Justin C St John; João Ramalho-Santos; Heather L Gray; Patti Petrosko; Vanesa Y Rawe; Christopher S Navara; Calvin Simerly; Gerald Schatten
The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells.
Cloning and stem cells 2005;7(3):141-53.
2004: João Ramalho-Santos; Alexandra Amaral; Raquel Brito; Mariana Freitas; teresa santos
Simultaneous analysis of cytoskeletal patterns and chromosome positioning in human fertilization failures.
Fertility and sterility 2004;82(6):1654-9.
2004: Vanesa Y Rawe; João Ramalho-Santos; Christopher Payne; Hector E Chemes; Gerald Schatten
WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis.
Human reproduction (Oxford, England) 2004;19(11):2594-604.
2004: Antonio Graça; João Ramalho-Santos; Maria de Lourdes Pereira
Effect of lead chloride on spermatogenesis and sperm parameters in mice.
Asian journal of andrology 2004;6(3):237-41.
2004: João Ramalho-Santos; Gerald Schatten
Presence of N-ethyl maleimide sensitive factor (NSF) on the acrosome of mammalian sperm.
Archives of andrology 2004;50(3):163-8.
2004: João Ramalho-Santos; Maria C Pedroso De Lima
The role of target membrane sialic acid residues in the fusion activity of the influenza virus: the effect of two types of ganglioside on the kinetics of membrane merging.
Cellular & molecular biology letters 2004;9(2):337-51.
2003: Christopher Payne; Vanesa Y Rawe; João Ramalho-Santos; Calvin Simerly; Gerald Schatten
Preferentially localized dynein and perinuclear dynactin associate with nuclear pore complex proteins to mediate genomic union during mammalian fertilization.
Journal of cell science 2003;116(Pt 23):4727-38.
2003: Christopher Payne; Justin C St John; João Ramalho-Santos; Gerald Schatten
LIS1 association with dynactin is required for nuclear motility and genomic union in the fertilized mammalian oocyte.
Cell motility and the cytoskeleton 2003;56(4):245-51.
2003: Winston E Thompson; João Ramalho-Santos; Peter Sutovsky
Ubiquitination of prohibitin in mammalian sperm mitochondria: possible roles in the regulation of mitochondrial inheritance and sperm quality control.
Biology of reproduction 2003;69(1):254-60.
2002: João Ramalho-Santos; Gerald Schatten; Ricardo D Moreno
Control of membrane fusion during spermiogenesis and the acrosome reaction.
Biology of reproduction 2002;67(4):1043-51.
2002: Ricardo D Moreno; Gerald Schatten; João Ramalho-Santos
Golgi apparatus dynamics during mouse oocyte in vitro maturation: effect of the membrane trafficking inhibitor brefeldin A.
Biology of reproduction 2002;66(5):1259-66.
2002: Isabel Nunes-Correia; Ana Eulálio; Shlomo Nir; Nejat Düzgünes; João Ramalho-Santos; Maria C Pedroso De Lima
Fluorescent probes for monitoring virus fusion kinetics: comparative evaluation of reliability.
Biochimica et biophysica acta 2002;1561(1):65-75.
2002: João Ramalho-Santos; Yukihiro Terada; Gerald Schatten
VAMP/synaptobrevin as an acrosomal marker for human sperm.
Fertility and sterility 2002;77(1):159-61.
2001: João Ramalho-Santos; Calvin Simerly; Laura Hewitson; Gerald Schatten
Acrosome components after intracytoplasmic sperm injection: the decondensation frontier.
Fertility and sterility 2001;76(1):196-7.
2001: João Ramalho-Santos; Ricardo D Moreno; GM Wessel; Edward Chan; Gerald Schatten
Membrane trafficking machinery components associated with the mammalian acrosome during spermiogenesis.
Experimental cell research 2001;267(1):45-60.
2001: João Ramalho-Santos; Maria C Pedroso de Lima
Fusion and infection of influenza and Sendai viruses as modulated by dextran sulfate: a comparative study.
Bioscience reports 2001;21(3):293-304.
2001: Peter Sutovsky; R Moreno; João Ramalho-Santos; Tanja Dominko; Winston E Thompson; Gerald Schatten
A putative, ubiquitin-dependent mechanism for the recognition and elimination of defective spermatozoa in the mammalian epididymis.
Journal of cell science 2001;114(Pt 9):1665-75.
2001: João Ramalho-Santos; Ricardo D Moreno
Targeting and fusion proteins during mammalian spermiogenesis.
Biological research 2001;34(2):147-52.
2000: João Ramalho-Santos; Peter Sutovsky; Calvin Simerly; Richard Oko; GM Wessel; Laura Hewitson; Gerald Schatten
ICSI choreography: fate of sperm structures after monospermic rhesus ICSI and first cell cycle implications.
Human reproduction (Oxford, England) 2000;15(12):2610-20.
2000: Peter Sutovsky; Ricardo D Moreno; João Ramalho-Santos; Tanja Dominko; Calvin Simerly; Gerald Schatten
Ubiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in mammalian embryos.
Biology of reproduction 2000;63(2):582-90.
2000: João Ramalho-Santos; Ricardo D Moreno; Peter Sutovsky; Anthony W S Chan; Laura Hewitson; GM Wessel; Calvin Simerly; Gerald Schatten
SNAREs in mammalian sperm: possible implications for fertilization.
Developmental biology 2000;223(1):54-69.
2000: Ricardo D Moreno; João Ramalho-Santos; Peter Sutovsky; Edward Chan; Gerald Schatten
Vesicular traffic and golgi apparatus dynamics during mammalian spermatogenesis: implications for acrosome architecture.
Biology of reproduction 2000;63(1):89-98.
2000: Anthony W S Chan; Craig Marc Luetjens; Tanja Dominko; João Ramalho-Santos; Calvin Simerly; Laura Hewitson; Gerald Schatten
TransgenICSI reviewed: foreign DNA transmission by intracytoplasmic sperm injection in rhesus monkey.
Molecular reproduction and development 2000;56(2 Suppl):325-8.
2000: Ricardo D Moreno; João Ramalho-Santos; Edward Chan; GM Wessel; Gerald Schatten
The Golgi apparatus segregates from the lysosomal/acrosomal vesicle during rhesus spermiogenesis: structural alterations.
Developmental biology 2000;219(2):334-49.
2000: Anthony W S Chan; Craig Marc Luetjens; Tanja Dominko; João Ramalho-Santos; Calvin Simerly; Laura Hewitson; Gerald Schatten
Foreign DNA transmission by ICSI: injection of spermatozoa bound with exogenous DNA results in embryonic GFP expression and live rhesus monkey births.
Molecular human reproduction 2000;6(1):26-33.
1999: Peter Sutovsky; Ricardo D Moreno; João Ramalho-Santos; Tanja Dominko; Calvin Simerly; Gerald Schatten
Ubiquitin tag for sperm mitochondria.
Nature 1999;402(6760):371-2.
1999: Peter Sutovsky; João Ramalho-Santos; Ricardo D Moreno; Richard Oko; Laura Hewitson; Gerald Schatten
On-stage selection of single round spermatids using a vital, mitochondrion-specific fluorescent probe MitoTracker(TM) and high resolution differential interference contrast microscopy.
Human reproduction (Oxford, England) 1999;14(9):2301-12.
1999: Laura Hewitson; Tanja Dominko; Diana Takahashi; Crista Martinovich; João Ramalho-Santos; Peter Sutovsky; John W Fanton; D Jacob; D Monteith; Martha Neuringer; David E Battaglia; Calvin Simerly; Gerald Schatten
Unique checkpoints during the first cell cycle of fertilization after intracytoplasmic sperm injection in rhesus monkeys.
Nature medicine 1999;5(4):431-3.
1999: Isabel Nunes-Correia; João Ramalho-Santos; Shlomo Nir; Maria C Pedroso De Lima
Interactions of influenza virus with cultured cells: detailed kinetic modeling of binding and endocytosis.
Biochemistry 1999;38(3):1095-101.
1999: Tanja Dominko; João Ramalho-Santos; Anthony W S Chan; Ricardo D Moreno; Craig Marc Luetjens; Calvin Simerly; Laura Hewitson; Diana Takahashi; Crista Martinovich; J M White; Gerald Schatten
Optimization strategies for production of mammalian embryos by nuclear transfer.
Cloning 1999;1(3):143-52.
1998: João Ramalho-Santos; Maria C Pedroso de Lima
The influenza virus hemagglutinin: a model protein in the study of membrane fusion.
Biochimica et biophysica acta 1998;1376(1):147-54.
1998: Isabel Nunes-Correia; João Ramalho-Santos; Maria C Pedroso De Lima
Sendai virus fusion activity as modulated by target membrane components.
Bioscience reports 1998;18(2):59-68.
1997: João Ramalho-Santos; Maria C Pedroso de Lima
Fusion activity of the influenza virus hemagglutinin does not require a transbilayer pH gradient.
Biochimica et biophysica acta 1997;1330(2):194-8.
1997: M T Almeida; João Ramalho-Santos; Catarina R Oliveira; Maria C Pedroso De Lima
Evidence that synaptobrevin is involved in fusion between synaptic vesicles and synaptic plasma membrane vesicles.
Biochemical and biophysical research communications 1997;236(1):184-8.
1996: João Ramalho-Santos; M C Lima; Shlomo Nir
Partial fusion activity of influenza virus toward liposomes and erythrocyte ghosts is distinct from viral inactivation.
The Journal of biological chemistry 1996;271(39):23902-6.
1995: Carlos E S Bernardes; M L Valdeira; João Ramalho-Santos; Maria C Pedroso de Lima
Fusion activity of African swine fever virus towards target membranes: lipid dependence and effect of dehydrating agents.
Biochemistry and molecular biology international 1995;37(3):481-8.
1995: Maria C Pedroso de Lima; João Ramalho-Santos; Diana L Flasher; V A Slepushkin; Shlomo Nir; N Düzgüneş
Target cell membrane sialic acid modulates both binding and fusion activity of influenza virus.
Biochimica et biophysica acta 1995;1236(2):323-30.
1994: M T Almeida; João Ramalho-Santos; Catarina R Oliveira; Maria C Pedroso de Lima
Parameters affecting fusion between liposomes and synaptosomes. Role of proteins, lipid peroxidation, pH and temperature.
The Journal of membrane biology 1994;142(2):217-22.
1994: João Ramalho-Santos; R Negrão; Maria C Pedroso de Lima
Fusion of Sendai virus with model membranes as affected by dehydrating agents and pH: correlation between viral envelope hydrophobicity and fusion activity.
Biochemistry and molecular biology international 1994;32(6):1121-7.
1994: João Ramalho-Santos; R Negrão; M da Conceição; P de Lima
Role of hydrophobic interactions in the fusion activity of influenza and Sendai viruses towards model membranes.
Bioscience reports 1994;14(1):15-24.
1993: João Ramalho-Santos; Shlomo Nir; Nejat Düzgünes; A P de Carvalho; M da C de Lima
A common mechanism for influenza virus fusion activity and inactivation.
Biochemistry 1993;32(11):2771-9.
1992: J Seppen; João Ramalho-Santos; A P de Carvalho; M ter Beest; Jan Willem Kok; Maria C Pedroso de Lima; Dick Hoekstra
Interaction of clathrin with large unilamellar phospholipid vesicles at neutral pH. Lipid dependence and protein penetration.
Biochimica et biophysica acta 1992;1106(1):209-15.
1992: Maria C Pedroso De Lima; João Ramalho-Santos; M F Martins; A Pato de Carvalho; V Bairos; Shlomo Nir
Kinetic modeling of Sendai virus fusion with PC-12 cells. Effect of pH and temperature on fusion and viral inactivation.
European journal of biochemistry / FEBS 1992;205(1):181-6.