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Nungavaram Ramamurthy

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Chemicals & Drugs

Living Beings

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Anatomy

Gingiva
Skin

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Ovariectomy

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Nungavaram S Ramamurthy; Robert Greenwald; Mohamed Y Celiker; Yuenian Shi
Experimental arthritis in rats induces biomarkers of periodontitis which are ameliorated by gene therapy with tissue inhibitor of matrix metalloproteinases.
Subir R Maitra; Sikha Bhaduri; Patrick D Valane; Taina Tervahartiala; Timo Sorsa; Nungavaram S Ramamurthy
Inhibition of matrix metalloproteinases by chemically modified tetracyclines in sepsis.
Emma Pirilä; Nungavaram S Ramamurthy; Timo Sorsa; Tuula Salo; Jarkko Hietanen; Päivi Maisi
Gelatinase A (MMP-2), collagenase-2 (MMP-8), and laminin-5 gamma2-chain expression in murine inflammatory bowel disease (ulcerative colitis).

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2005: Nungavaram S Ramamurthy; Robert Greenwald; Mohamed Y Celiker; Yuenian Shi
Experimental arthritis in rats induces biomarkers of periodontitis which are ameliorated by gene therapy with tissue inhibitor of matrix metalloproteinases.
Journal of periodontology 2005;76(2):229-33.
2003: Subir R Maitra; Sikha Bhaduri; Patrick D Valane; Taina Tervahartiala; Timo Sorsa; Nungavaram S Ramamurthy
Inhibition of matrix metalloproteinases by chemically modified tetracyclines in sepsis.
Shock (Augusta, Ga.) 2003;20(3):280-5.
2003: Emma Pirilä; Nungavaram S Ramamurthy; Timo Sorsa; Tuula Salo; Jarkko Hietanen; Päivi Maisi
Gelatinase A (MMP-2), collagenase-2 (MMP-8), and laminin-5 gamma2-chain expression in murine inflammatory bowel disease (ulcerative colitis).
Digestive diseases and sciences 2003;48(1):93-8.
2002: Mahmut Y Celiker; Nungavaram S Ramamurthy; Jin-Wen Xu; Mingsheng Wang; Yangfu Jiang; Robert Greenwald; Yuenian Shi
Inhibition of adjuvant-induced arthritis by systemic tissue inhibitor of metalloproteinases 4 gene delivery.
Arthritis and rheumatism 2002;46(12):3361-8.
2002: Nungavaram S Ramamurthy; Barry R Rifkin; Robert Greenwald; Jing-Wen Xu; Yu Liu; Gloria Turner; Lorne M Golub; Anthony T Vernillo
Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines.
Journal of periodontology 2002;73(7):726-34.
2002: Nungavaram S Ramamurthy; Jing-wen Xu; John Bird; Andy Baxter; Ranjev Bhogal; Ruth Wills; Bob Watson; David Owen; Mark Wolff; Robert Greenwald
Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in experimental periodontal disease.
Journal of periodontal research 2002;37(1):1-7.
2002: Emma Pirilä; Mataleena Parikka; Nungavaram S Ramamurthy; Päivi Maisi; Steve McClain; Allan Kucine; Taina Tervahartiala; Kaiu Prikk; Lorne M Golub; Tuula Salo; Timo Sorsa
Chemically modified tetracycline (CMT-8) and estrogen promote wound healing in ovariectomized rats: effects on matrix metalloproteinase-2, membrane type 1 matrix metalloproteinase, and laminin-5 gamma2-chain.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2002;10(1):38-51.
2002: Daniel Grenier; Pascale Plamondon; T Sorsa; H M Lee; TF McNamara; Nungavaram S Ramamurthy; Lorne M Golub; Olli Teronen; Denis Mayrand
Inhibition of proteolytic, serpinolytic, and progelatinase-b activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives.
Journal of periodontology 2002;73(1):79-85.
2001: A Llavaneras; Nungavaram S Ramamurthy; P Heikkilä; Olli Teronen; Tuula Salo; Barry R Rifkin; Maria E Ryan; Lorne M Golub; Timo Sorsa
A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats.
Journal of periodontology 2001;72(8):1069-77.
2001: Maria E Ryan; A Usman; Nungavaram S Ramamurthy; Lorne M Golub; Robert Greenwald
Excessive matrix metalloproteinase activity in diabetes: inhibition by tetracycline analogues with zinc reactivity.
Current medicinal chemistry 2001;8(3):305-16.
2001: Nungavaram S Ramamurthy; S Bain; C T Liang; J Barnes; A Llavaneras; Yu Liu; D Puerner; M J Strachan; Lorne M Golub
A combination of subtherapeutic doses of chemically modified doxycycline (CMT-8) and a bisphosphonate (clodronate) inhibits bone loss in the ovariectomized rat: a dynamic histomorphometric and gene expression study.
Current medicinal chemistry 2001;8(3):295-303.
2001: Emma Pirilä; Nungavaram S Ramamurthy; Päivi Maisi; Steve McClain; Allan Kucine; Jaana Wahlgren; Lorne M Golub; Tuula Salo; Timo Sorsa
Wound healing in ovariectomized rats: effects of chemically modified tetracycline (CMT-8) and estrogen on matrix metalloproteinases -8, -13 and type I collagen expression.
Current medicinal chemistry 2001;8(3):281-94.
2001: J Chen; M Bookbinder; Maria E Ryan; Lorne M Golub; R Ashley; Nungavaram S Ramamurthy
Biodistribution of radiolabeled [(3)H] CMT-3 in rats.
Current medicinal chemistry 2001;8(3):253-6.
2001: Yu Liu; Nungavaram S Ramamurthy; J Marecek; Hsi-Ming Lee; J L Chen; Maria E Ryan; Barry R Rifkin; Lorne M Golub
The lipophilicity, pharmacokinetics, and cellular uptake of different chemically-modified tetracyclines (CMTs).
Current medicinal chemistry 2001;8(3):243-52.
1999: David E Carney; Charles J Lutz; Anthony Picone; Louis A Gatto; Nungavaram S Ramamurthy; Lorne M Golub; S R Simon; Bruce Searles; AM Paskanik; K Snyder; CM Finck; Henry J Schiller; Gary F Nieman
Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass.
Circulation 1999;100(4):400-6.
1999: Nungavaram S Ramamurthy; Steve McClain; E Pirila; Päivi Maisi; Tuula Salo; Allan Kucine; Timo Sorsa; F Vishram; Lorne M Golub
Wound healing in aged normal and ovariectomized rats: effects of chemically modified doxycycline (CMT-8) on MMP expression and collagen synthesis.
Annals of the New York Academy of Sciences 1999;878():720-3.
1999: A Llavaneras; Lorne M Golub; Barry R Rifkin; P Heikkilä; Timo Sorsa; Olli Teronen; Tuula Salo; Yu Liu; Maria E Ryan; Nungavaram S Ramamurthy
CMT-8/clodronate combination therapy synergistically inhibits alveolar bone loss in LPS-induced periodontitis.
Annals of the New York Academy of Sciences 1999;878():671-4.
1999: Takahisa Sasaki; N Ohyori; Kazuhiro Debari; Nungavaram S Ramamurthy; Lorne M Golub
Effects of chemically modified tetracycline, CMT-8, on bone loss and osteoclast structure and function in osteoporotic states.
Annals of the New York Academy of Sciences 1999;878():347-60.
1999: Maria E Ryan; Nungavaram S Ramamurthy; T Sorsa; Lorne M Golub
MMP-mediated events in diabetes.
Annals of the New York Academy of Sciences 1999;878():311-34.
1999: Lorne M Golub; Nungavaram S Ramamurthy; A Llavaneras; Maria E Ryan; Hsi-Ming Lee; Yu Liu; S Bain; Timo Sorsa
A chemically modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats.
Annals of the New York Academy of Sciences 1999;878():290-310.
1999: A Ishihara; Takahisa Sasaki; Kazuhiro Debari; Ryoichi Furuya; Tadaharu Kawawa; Nungavaram S Ramamurthy; L M Golub
Effects of ovariectomy on bone morphology in maxillae of mature rats.
Journal of electron microscopy 1999;48(4):465-9.
1998: Maria E Ryan; Nungavaram S Ramamurthy; Lorne M Golub
Tetracyclines inhibit protein glycation in experimental diabetes.
Advances in dental research 1998;12(2):152-8.
1998: Nungavaram S Ramamurthy; Allan Kucine; Steve McClain; TF McNamara; Lorne M Golub
Topically applied CMT-2 enhances wound healing in streptozotocin diabetic rat skin.
Advances in dental research 1998;12(2):144-8.
1998: T Sasaki; Nungavaram S Ramamurthy; Lorne M Golub
Long-term therapy with a new chemically modified tetracycline (CMT-8) inhibits bone loss in femurs of ovariectomized rats.
Advances in dental research 1998;12(2):76-81.
1998: Howard A Israel; Nungavaram S Ramamurthy; Robert Greenwald; Lorne M Golub
The potential role of doxycycline in the treatment of osteoarthritis of the temporomandibular joint.
Advances in dental research 1998;12(2):51-5.
1998: Nungavaram S Ramamurthy; K L Schroeder; TF McNamara; A J Gwinnett; R T Evans; C Bosko; Lorne M Golub
Root-surface caries in rats and humans: inhibition by a non-antimicrobial property of tetracyclines.
Advances in dental research 1998;12(2):43-50.
1998: Waldemar Pruzanski; E Stefanski; Peter Vadas; TF McNamara; Nungavaram S Ramamurthy; Lorne M Golub
Chemically modified non-antimicrobial tetracyclines inhibit activity of phospholipases A2.
The Journal of rheumatology 1998;25(9):1807-12.
1998: Timo Sorsa; Nungavaram S Ramamurthy; Anthony T Vernillo; X Zhang; Y T Konttinen; Barry R Rifkin; Lorne M Golub
Functional sites of chemically modified tetracyclines: inhibition of the oxidative activation of human neutrophil and chicken osteoclast pro-matrix metalloproteinases.
The Journal of rheumatology 1998;25(5):975-82.
1998: Ronald G Craig; Z Yu; L Xu; R Barr; Nungavaram S Ramamurthy; J Boland; M Schneir; Lorne M Golub
A chemically modified tetracycline inhibits streptozotocin-induced diabetic depression of skin collagen synthesis and steady-state type I procollagen mRNA.
Biochimica et biophysica acta 1998;1402(3):250-60.
1998: Nadeem Y Karimbux; Nungavaram S Ramamurthy; Lorne M Golub; Ichiro Nishimura
The expression of collagen I and XII mRNAs in Porphyromonas gingivalis-induced periodontitis in rats: the effect of doxycycline and chemically modified tetracycline.
Journal of periodontology 1998;69(1):34-40.
1998: Robert Greenwald; Lorne M Golub; Nungavaram S Ramamurthy; M Chowdhury; SA Moak; Timo Sorsa
In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.
Bone 1998;22(1):33-8.
1997: S Bain; Nungavaram S Ramamurthy; T Impeduglia; S Scolman; Lorne M Golub; C Rubin
Tetracycline prevents cancellous bone loss and maintains near-normal rates of bone formation in streptozotocin diabetic rats.
Bone 1997;21(2):147-53.
1997: Waldemar Pruzanski; E Stefanski; Peter Vadas; Nungavaram S Ramamurthy
Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity.
Biochemical pharmacology 1997;53(12):1901-7.
1996: K M Chang; M E Ryan; Lorne M Golub; Nungavaram S Ramamurthy; TF McNamara
Local and systemic factors in periodontal disease increase matrix-degrading enzyme activities in rat gingiva: effect of micocycline therapy.
Research communications in molecular pathology and pharmacology 1996;91(3):303-18.
1995: M K Leung; Robert Greenwald; Nungavaram S Ramamurthy; SA Moak; R Koszulinski; D Dieudonne; Lorne M Golub
Tenidap and flurbiprofen enhance uptake of matrix metalloproteinase inhibitor 4-dedimethylaminotetracycline in inflamed joints of adjuvant arthritic rats.
The Journal of rheumatology 1995;22(9):1726-31.
1995: Olli Teronen; Tuula Salo; Yrjö T Konttinen; Barry R Rifkin; Anthony T Vernillo; Nungavaram S Ramamurthy; L Kjeldsen; N Borregaard; Jarkko Hietanen; Timo Sorsa
Identification and characterization of gelatinases/type IV collagenases in jaw cysts.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 1995;24(2):78-84.
1994: Lorne M Golub; R T Evans; TF McNamara; H M Lee; Nungavaram S Ramamurthy
A non-antimicrobial tetracycline inhibits gingival matrix metalloproteinases and bone loss in Porphyromonas gingivalis-induced periodontitis in rats.
Annals of the New York Academy of Sciences 1994;732():96-111.
1994: Olli Teronen; Tuula Salo; Yrjö T Konttinen; Barry R Rifkin; Anthony T Vernillo; Nungavaram S Ramamurthy; L Kjeldsen; N Borregaard; C P Sommerhoff; Timo Sorsa
Gelatinases/type IV collagenases in jaw cyst expansion.
Annals of the New York Academy of Sciences 1994;732():486-8.
1994: Nungavaram S Ramamurthy; Robert Greenwald; S Moak; J Scuibba; A Goren; G Turner; B Rifkin; Lorne M Golub
CMT/Tenidap treatment inhibits temporomandibular joint destruction in adjuvant arthritic rats.
Annals of the New York Academy of Sciences 1994;732():427-30.
1994: Barry R Rifkin; Anthony T Vernillo; Lorne M Golub; Nungavaram S Ramamurthy
Modulation of bone resorption by tetracyclines.
Annals of the New York Academy of Sciences 1994;732():165-80.
1994: K M Chang; Nungavaram S Ramamurthy; TF McNamara; R T Evans; B Klausen; P A Murray; Lorne M Golub
Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism.
Journal of periodontal research 1994;29(4):242-9.
1994: Anthony T Vernillo; Nungavaram S Ramamurthy; Lorne M Golub; Barry R Rifkin
The nonantimicrobial properties of tetracycline for the treatment of periodontal disease.
Current opinion in periodontology 1994;():111-8.
1993: Nungavaram S Ramamurthy; M Leung; S Moak; Robert Greenwald; Lorne M Golub
CMT/NSAID combination increases bone CMT uptake and inhibits bone resorption.
Annals of the New York Academy of Sciences 1993;696():420-1.
1993: Z Yu; Nungavaram S Ramamurthy; M Leung; K M Chang; TF McNamara; Lorne M Golub
Chemically-modified tetracycline normalizes collagen metabolism in diabetic rats: a dose-response study.
Journal of periodontal research 1993;28(6 Pt 1):420-8.
1993: Nungavaram S Ramamurthy; Anthony T Vernillo; Robert Greenwald; Hsi-Ming Lee; Timo Sorsa; Lorne M Golub; Barry R Rifkin
Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(10):1247-53.
1992: B S Schneider; J Maimon; Lorne M Golub; Nungavaram S Ramamurthy; Robert Greenwald
Tetracyclines inhibit intracellular muscle proteolysis in vitro.
Biochemical and biophysical research communications 1992;188(2):767-72.
1992: Robert Greenwald; SA Moak; Nungavaram S Ramamurthy; Lorne M Golub
Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage.
The Journal of rheumatology 1992;19(6):927-38.
1992: Anthony T Vernillo; Nungavaram S Ramamurthy; H M Lee; Barry R Rifkin
Parathyroid hormone regulation of matrix degrading enzymes in rat osteoblastic osteosarcoma 17/2.8 cells.
Research communications in chemical pathology and pharmacology 1992;75(3):323-39.
1992: Z Yu; M K Leung; Nungavaram S Ramamurthy; TF McNamara; Lorne M Golub
HPLC determination of a chemically modified nonantimicrobial tetracycline: biological implications.
Biochemical medicine and metabolic biology 1992;47(1):10-20.
1992: Lorne M Golub; Robert Greenwald; Nungavaram S Ramamurthy; S Zucker; L Ramsammy; T McNamara
Tetracyclines (TCs) inhibit matrix metalloproteinases (MMPs): in vivo effects in arthritic and diabetic rats and new in vitro studies.
Matrix (Stuttgart, Germany). Supplement 1992;1():315-6.
1992: K Suomalainen; Timo Sorsa; Lorne M Golub; Nungavaram S Ramamurthy; H M Lee; Veli-Jukka Uitto; H Saari; Yrjö T Konttinen
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.
Antimicrobial agents and chemotherapy 1992;36(1):227-9.
1991: Lorne M Golub; Nungavaram S Ramamurthy; TF McNamara; Robert Greenwald; Barry R Rifkin
Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 1991;2(3):297-321.
1990: Nungavaram S Ramamurthy; Anthony T Vernillo; H M Lee; Lorne M Golub; Barry R Rifkin
The effect of tetracyclines on collagenase activity in UMR 106-01 rat osteoblastic osteosarcoma cells.
Research communications in chemical pathology and pharmacology 1990;70(3):323-35.
1990: M Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Minocycline-treatment of diabetic rats normalizes skin collagen production and mass: possible causative mechanisms.
Matrix (Stuttgart, Germany) 1990;10(2):112-23.
1990: Lorne M Golub; Nungavaram S Ramamurthy; H Kaneko; T Sasaki; Barry R Rifkin; TF McNamara
Tetracycline administration prevents diabetes-induced osteopenia in the rat: initial observations.
Research communications in chemical pathology and pharmacology 1990;68(1):27-40.
1990: Anthony T Vernillo; Nungavaram S Ramamurthy; H M Lee; Barry R Rifkin
The effect of phenytoin on collagenase and gelatinase activities in UMR 106-01 rat osteoblastic osteosarcoma cells.
Matrix (Stuttgart, Germany) 1990;10(1):27-32.
1988: K M Chang; Nungavaram S Ramamurthy; TF McNamara; R J Genco; Lorne M Golub
Infection with a gram-negative organism stimulates gingival collagenase production in non-diabetic and diabetic germfree rats.
Journal of periodontal research 1988;23(4):239-44.
1988: M Schneir; M Imberman; Nungavaram S Ramamurthy; Lorne M Golub
Streptozotocin-induced diabetes and the rat periodontium: decreased relative collagen production.
Collagen and related research 1988;8(3):221-32.
1988: Robert Greenwald; B G Simonson; SA Moak; S W Rush; Nungavaram S Ramamurthy; R S Laskin; Lorne M Golub
Inhibition of epiphyseal cartilage collagenase by tetracyclines in low phosphate rickets in rats.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1988;6(5):695-703.
1987: Lorne M Golub; TF McNamara; G D'Angelo; Robert Greenwald; Nungavaram S Ramamurthy
A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity.
Journal of dental research 1987;66(8):1310-4.
1987: Robert Greenwald; Lorne M Golub; B Lavietes; Nungavaram S Ramamurthy; B Gruber; R S Laskin; TF McNamara
Tetracyclines inhibit human synovial collagenase in vivo and in vitro.
The Journal of rheumatology 1987;14(1):28-32.
1986: M Imberman; Nungavaram S Ramamurthy; Lorne M Golub; M Schneir
A reassessment of collagen half-life in rat periodontal tissues: application of the pool-expansion approach.
Journal of periodontal research 1986;21(4):396-402.
1986: M K Leung; G A Folkes; Nungavaram S Ramamurthy; M Schneir; Lorne M Golub
Diabetes stimulates procollagen degradation in rat tendon in vitro.
Biochimica et biophysica acta 1986;880(2-3):147-52.
1986: M Schneir; M Imberman; Nungavaram S Ramamurthy; Lorne M Golub
The in vivo fractional rate of gingival collagen production in non-diabetic and diabetic rats. Application of a novel approach for quantification-pool expansion.
Journal of periodontal research 1986;21(1):56-63.
1985: M Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Dietary ascorbic acid normalizes diabetes-induced underhydroxylation of nascent type I collagen molecules.
Collagen and related research 1985;5(5):415-22.
1985: M Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Enhanced intracellular procollagen degradation in skins of streptozotocin-induced diabetic rats: a causal relationship to underhydroxylation.
Progress in clinical and biological research 1985;180():667-8.
1985: Nungavaram S Ramamurthy; Robert Greenwald; M Schneir; Lorne M Golub
The effect of alloxan diabetes on prolyl and lysyl hydroxylase activity in uninflamed and inflamed rat gingiva.
Archives of oral biology 1985;30(9):679-83.
1984: Lorne M Golub; Nungavaram S Ramamurthy; T F McNamara; B Gomes; M Wolff; A Casino; A Kapoor; J Zambon; S Ciancio; M Schneir
Tetracyclines inhibit tissue collagenase activity. A new mechanism in the treatment of periodontal disease.
Journal of periodontal research 1984;19(6):651-5.
1984: M Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Skin collagen metabolism in the streptozotocin-induced diabetic rat: free hydroxyproline, the principal in vivo degradation product of newly synthesized collagen--probably procollagen.
Collagen and related research 1984;4(3):183-93.
1984: M L Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Extensive degradation of recently synthesized collagen in gingiva of normal and streptozotocin-induced diabetic rats.
Journal of dental research 1984;63(1):23-7.
1982: M Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Skin collagen metabolism in the streptozotocin-induced diabetic rat. Enhanced catabolism of collagen formed both before and during the diabetic state.
Diabetes 1982;31(5 Pt 1):426-31.