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Theodore Randolph

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Procedures

Chemicals & Drugs

Physiology

Protein Folding

Concepts & Ideas

Occupations

Phenomena

Circular Dichroism

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Network (preview)

Co-Publications
Name
73
Carpenter, John
25
Manning, Mark
14
Kendrick, Brent
7
Jones, LaToya
7
Chang, Byeong
7
Cleland, Jeffrey
7
Krishnan, Sampathkumar
7
Chi, Eva
6
Lengsfeld, Corinne
6
Heller, MC
5
Seefeldt, Matthew
5
Webb, Serena
4
Roy, Shouvik
4
Stoner, Michael
4
Nayar, Rajiv

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Publications

TOP 3
Fradkin Amber Haynes; Carpenter John F; Randolph Theodore W
Immunogenicity of aggregates of recombinant human growth hormone in mouse models.
Bee Jared S; Chiu David; Sawicki Suzanne; Stevenson Jennifer L; Chatterjee Koustuv; Freund Erwin; Carpenter John F; Randolph Theodore W
Monoclonal antibody interactions with micro- and nanoparticles: adsorption, aggregation, and accelerated stress studies.
Bee Jared S; Nelson Stephanie A; Freund Erwin; Carpenter John F; Randolph Theodore W
Precipitation of a monoclonal antibody by soluble tungsten.

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All Publications

2009: Fradkin Amber Haynes; Carpenter John F; Randolph Theodore W
Immunogenicity of aggregates of recombinant human growth hormone in mouse models.
Journal of pharmaceutical sciences 2009;98(9):3247-64.
2009: Bee Jared S; Chiu David; Sawicki Suzanne; Stevenson Jennifer L; Chatterjee Koustuv; Freund Erwin; Carpenter John F; Randolph Theodore W
Monoclonal antibody interactions with micro- and nanoparticles: adsorption, aggregation, and accelerated stress studies.
Journal of pharmaceutical sciences 2009;98(9):3218-38.
2009: Bee Jared S; Nelson Stephanie A; Freund Erwin; Carpenter John F; Randolph Theodore W
Precipitation of a monoclonal antibody by soluble tungsten.
Journal of pharmaceutical sciences 2009;98(9):3290-301.
2009: Estey Tia; Vessely Christina; Randolph Theodore W; Henderson Ian; Braun Latoya Jones; Nayar Rajiv; Carpenter John F
Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry.
Journal of pharmaceutical sciences 2009;98(9):2994-3012.
2009: Vessely Christina; Estey Tia; Randolph Theodore W; Henderson Ian; Cooper Julianne; Nayar Rajiv; Braun Latoya Jones; Carpenter John F
Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution.
Journal of pharmaceutical sciences 2009;98(9):2970-93.
2009: Katayama Derrick S; Carpenter John F; Menard Kevin P; Manning Mark Cornell; Randolph Theodore W
Mixing properties of lyophilized protein systems: a spectroscopic and calorimetric study.
Journal of pharmaceutical sciences 2009;98(9):2954-69.
2009: Bee Jared S; Stevenson Jennifer L; Mehta Bhavya; Svitel Juraj; Pollastrini Joey; Platz Robert; Freund Erwin; Carpenter John F; Randolph Theodore W
Response of a concentrated monoclonal antibody formulation to high shear.
Biotechnology and bioengineering 2009;103(5):936-43.
2009: Carpenter John F; Randolph Theodore W; Jiskoot Wim; Crommelin Daan J A; Middaugh C Russell; Winter Gerhard; Fan Ying-Xin; Kirshner Susan; Verthelyi Daniela; Kozlowski Steven; Clouse Kathleen A; Swann Patrick G; Rosenberg Amy; Cherney Barry
Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.
Journal of pharmaceutical sciences 2009;98(4):1201-5.
2009: Crisman Ryan L; Randolph Theodore W
Refolding of proteins from inclusion bodies is favored by a diminished hydrophobic effect at elevated pressures.
Biotechnology and bioengineering 2009;102(2):483-92.
2009: Clausi Amber L; Morin Andrea; Carpenter John F; Randolph Theodore W
Influence of protein conformation and adjuvant aggregation on the effectiveness of aluminum hydroxide adjuvant in a model alkaline phosphatase vaccine.
Journal of pharmaceutical sciences 2009;98(1):114-21.
2009: Tyagi Anil K; Randolph Theodore W; Dong Aichun; Maloney Kevin M; Hitscherich Carl; Carpenter John F
IgG particle formation during filling pump operation: a case study of heterogeneous nucleation on stainless steel nanoparticles.
Journal of pharmaceutical sciences 2009;98(1):94-104.
2008: Roy Shouvik; Henderson Ian; Nayar Rajiv; Randolph Theodore W; Carpenter John F
Effect of pH on stability of recombinant botulinum serotype A vaccine in aqueous solution and during storage of freeze-dried formulations.
Journal of pharmaceutical sciences 2008;97(12):5132-46.
2008: Clausi Amber; Cummiskey Jessica; Merkley Scott; Carpenter John F; Braun Latoya Jones; Randolph Theodore W
Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine.
Journal of pharmaceutical sciences 2008;97(12):5252-62.
2008: Alford John R; Kwok Stanley C; Roberts Jennifer N; Wuttke Deborah S; Kendrick Brent S; Carpenter John F; Randolph Theodore W
High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization.
Journal of pharmaceutical sciences 2008;97(8):3035-50.
2008: Alford John R; Kendrick Brent S; Carpenter John F; Randolph Theodore W
High concentration formulations of recombinant human interleukin-1 receptor antagonist: II. Aggregation kinetics.
Journal of pharmaceutical sciences 2008;97(8):3005-21.
2008: Alford John R; Kendrick Brent S; Carpenter John F; Randolph Theodore W
Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium.
Analytical biochemistry 2008;377(2):128-33.
2008: Clausi Amber L; Merkley Scott A; Carpenter John F; Randolph Theodore W
Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying.
Journal of pharmaceutical sciences 2008;97(6):2049-61.
2008: Kueltzo Lisa A; Wang Wei; Randolph Theodore W; Carpenter John F
Effects of solution conditions, processing parameters, and container materials on aggregation of a monoclonal antibody during freeze-thawing.
Journal of pharmaceutical sciences 2008;97(5):1801-12.
2008: Katayama Derrick S; Carpenter John F; Manning Mark Cornell; Randolph Theodore W; Setlow Peter; Menard Kevin P
Characterization of amorphous solids with weak glass transitions using high ramp rate differential scanning calorimetry.
Journal of pharmaceutical sciences 2008;97(2):1013-24.
2007: Seefeldt Matthew B; Crouch Chris; Kendrick Brent; Randolph Theodore W
Specific volume and adiabatic compressibility measurements of native and aggregated recombinant human interleukin-1 receptor antagonist: density differences enable pressure-modulated refolding.
Biotechnology and bioengineering 2007;98(2):476-85.
2007: Vessely Christina; Estey Tia; Randolph Theodore W; Henderson Ian; Nayar Rajiv; Carpenter John F
Effects of solution conditions and surface chemistry on the adsorption of three recombinant botulinum neurotoxin antigens to aluminum salt adjuvants.
Journal of pharmaceutical sciences 2007;96(9):2375-89.
2007: Thirumangalathu Renuka; Krishnan Sampathkumar; Bondarenko Pavel; Speed-Ricci Margaret; Randolph Theodore W; Carpenter John F; Brems David N
Oxidation of methionine residues in recombinant human interleukin-1 receptor antagonist: implications of conformational stability on protein oxidation kinetics.
Biochemistry 2007;46(21):6213-24.
2007: Gabrielson John P; Randolph Theodore W; Kendrick Brent S; Stoner Michael R
Sedimentation velocity analytical ultracentrifugation and SEDFIT/c(s): limits of quantitation for a monoclonal antibody system.
Analytical biochemistry 2007;361(1):24-30.
2007: Gabrielson John P; Brader Mark L; Pekar Allen H; Mathis Kathrin B; Winter Gerhard; Carpenter John F; Randolph Theodore W
Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity.
Journal of pharmaceutical sciences 2007;96(2):268-79.
2006: Thirumangalathu Renuka; Krishnan Sampathkumar; Brems David N; Randolph Theodore W; Carpenter John F
Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factor.
Journal of pharmaceutical sciences 2006;95(7):1480-97.
2006: Roy Shouvik; Katayama Derrick; Dong Aichun; Kerwin Bruce A; Randolph Theodore W; Carpenter John F
Temperature dependence of benzyl alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist.
Biochemistry 2006;45(12):3898-911.
2006: Lee Seung-Hyun; Carpenter John F; Chang Byeong S; Randolph Theodore W; Kim Yong-Sung
Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure.
Protein science : a publication of the Protein Society 2006;15(2):304-13.
2006: Stoner Michael R; Dale Douglas A; Gualfetti Peter J; Becker Todd; Randolph Theodore W
Surfactant-induced unfolding of cellulase: kinetic studies.
Biotechnology progress 2006;22(1):225-32.
2006: Kim Yong-Sung; Randolph Theodore W; Seefeldt Matthew B; Carpenter John F
High-pressure studies on protein aggregates and amyloid fibrils.
Methods in enzymology 2006;413():237-53.
2005: Chi Eva Y; Kendrick Brent S; Carpenter John F; Randolph Theodore W
Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist.
Journal of pharmaceutical sciences 2005;94(12):2735-48.
2005: Jarmer Daniel J; Lengsfeld Corinne S; Anseth Kristi S; Randolph Theodore W
Supercritical fluid crystallization of griseofulvin: crystal habit modification with a selective growth inhibitor.
Journal of pharmaceutical sciences 2005;94(12):2688-702.
2005: Stoner Michael R; Dale Douglas A; Gualfetti Peter J; Becker Todd; Randolph Theodore W
Ca2+-surfactant interactions affect enzyme stability in detergent solutions.
Biotechnology progress 2005;21(6):1716-23.
2005: Zhou Huiyu; Zhang Yanling; Biggs Danielle L; Manning Mark C; Randolph Theodore W; Christians Uwe; Hybertson Brooks M; Ng Ka-yun
Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages.
Journal of controlled release : official journal of the Controlled Release Society 2005;107(2):288-99.
2005: Seefeldt Matthew B; Kim Yong-Sung; Tolley Kevin P; Seely Jim; Carpenter John F; Randolph Theodore W
High-pressure studies of aggregation of recombinant human interleukin-1 receptor antagonist: thermodynamics, kinetics, and application to accelerated formulation studies.
Protein science : a publication of the Protein Society 2005;14(9):2258-66.
2005: Chou Danny K; Krishnamurthy Rajesh; Randolph Theodore W; Carpenter John F; Manning Mark Cornell
Effects of Tween 20 and Tween 80 on the stability of Albutropin during agitation.
Journal of pharmaceutical sciences 2005;94(6):1368-81.
2005: Roy Shouvik; Jung Rose; Kerwin Bruce A; Randolph Theodore W; Carpenter John F
Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations.
Journal of pharmaceutical sciences 2005;94(2):382-96.
2005: Chi Eva Y; Weickmann Joachim; Carpenter John F; Manning Mark C; Randolph Theodore W
Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation.
Journal of pharmaceutical sciences 2005;94(2):256-74.
2004: Zhang Ye; Roy Shouvik; Jones Latoya S; Krishnan Sampathkumar; Kerwin Bruce A; Chang Byeong S; Manning Mark C; Randolph Theodore W; Carpenter John F
Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution.
Journal of pharmaceutical sciences 2004;93(12):3076-89.
2004: Seefeldt Matthew B; Ouyang Jun; Froland Wayne A; Carpenter John F; Randolph Theodore W
High-pressure refolding of bikunin: efficacy and thermodynamics.
Protein science : a publication of the Protein Society 2004;13(10):2639-50.
2004: Patel Mayank M; Zeles Michelle G; Manning Mark C; Randolph Theodore W; Anchordoquy Thomas J
Degradation kinetics of high molecular weight poly(L-lactide) microspheres and release mechanism of lipid:DNA complexes.
Journal of pharmaceutical sciences 2004;93(10):2573-84.
2004: Stoner Michael R; Fischer Norm; Nixon Lori; Buckel Scott; Benke Mark; Austin Fred; Randolph Theodore W; Kendrick Brent S
Protein-solute interactions affect the outcome of ultrafiltration/diafiltration operations.
Journal of pharmaceutical sciences 2004;93(9):2332-42.
2004: Jarmer Daniel J; Lengsfeld Corinne S; Randolph Theodore W
Nucleation and growth rates of poly(L-lactic acid) microparticles during precipitation with a compressed-fluid antisolvent.
Langmuir : the ACS journal of surfaces and colloids 2004;20(17):7254-64.
2004: Garzon-Rodriguez William; Koval Rebecca L; Chongprasert Suchart; Krishnan Sampathkumar; Randolph Theodore W; Warne Nicholas W; Carpenter John F
Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures.
Journal of pharmaceutical sciences 2004;93(3):684-96.
2003: Chi Eva Y; Krishnan Sampathkumar; Randolph Theodore W; Carpenter John F
Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation.
Pharmaceutical research 2003;20(9):1325-36.
2003: Biggs Danielle L; Lengsfeld Corinne S; Hybertson Brooks M; Ng Ka-yun; Manning Mark C; Randolph Theodore W
In vitro and in vivo evaluation of the effects of PLA microparticle crystallinity on cellular response.
Journal of controlled release : official journal of the Controlled Release Society 2003;92(1-2):147-61.
2003: Kim Yong-Sung; Jones Latoya S; Dong Aichun; Kendrick Brent S; Chang Byeong S; Manning Mark C; Randolph Theodore W; Carpenter John F
Effects of sucrose on conformational equilibria and fluctuations within the native-state ensemble of proteins.
Protein science : a publication of the Protein Society 2003;12(6):1252-61.
2003: Chi Eva Y; Krishnan Sampathkumar; Kendrick Brent S; Chang Byeong S; Carpenter John F; Randolph Theodore W
Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor.
Protein science : a publication of the Protein Society 2003;12(5):903-13.
2003: Webb Serena D; Cleland Jeffrey L; Carpenter John F; Randolph Theodore W
Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma.
Journal of pharmaceutical sciences 2003;92(4):715-29.
2003: Kim Yong-Sung; Randolph Theodore W; Manning Mark C; Stevens Fred J; Carpenter John F
Congo red populates partially unfolded states of an amyloidogenic protein to enhance aggregation and amyloid fibril formation.
The Journal of biological chemistry 2003;278(12):10842-50.
2003: Stay Matthew S; Xu Jing; Randolph Theodore W; Barocas Victor H
Computer simulation of convective and diffusive transport of controlled-release drugs in the vitreous humor.
Pharmaceutical research 2003;20(1):96-102.
2003: Krishnan Sampathkumar; Chi Eva Y; Wood Stephen J; Kendrick Brent S; Li Cynthia; Garzon-Rodriguez William; Wypych Jette; Randolph Theodore W; Narhi Linda O; Biere Anja Leona; Citron Martin; Carpenter John F
Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.
Biochemistry 2003;42(3):829-37.
2002: Lengsfeld C S; Pitera D; Manning M; Randolph T W
Dissolution and partitioning behavior of hydrophobic ion-paired compounds.
Pharmaceutical research 2002;19(10):1572-6.
2002: Lengsfeld Corinne S; Manning Mark C; Randolph Theodore W
Encapsulating DNA within biodegradable polymeric microparticles.
Current pharmaceutical biotechnology 2002;3(3):227-35.
2002: Kim Yong-Sung; Randolph Theodore W; Stevens Fred J; Carpenter John F
Kinetics and energetics of assembly, nucleation, and growth of aggregates and fibrils for an amyloidogenic protein. Insights into transition states from pressure, temperature, and co-solute studies.
The Journal of biological chemistry 2002;277(30):27240-6.
2002: Zhou Huiyu; Lengsfeld Corinne; Claffey David J; Ruth James A; Hybertson Brooks; Randolph Theodore W; Ng Ka-Yun; Manning Mark C
Hydrophobic ion pairing of isoniazid using a prodrug approach.
Journal of pharmaceutical sciences 2002;91(6):1502-11.
2002: Webb Serena D; Golledge Stephen L; Cleland Jeffrey L; Carpenter John F; Randolph Theodore W
Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations.
Journal of pharmaceutical sciences 2002;91(6):1474-87.
2002: St John Richard J; Carpenter John F; Randolph Theodore W
High-pressure refolding of disulfide-cross-linked lysozyme aggregates: thermodynamics and optimization.
Biotechnology progress 2002;18(3):565-71.
2002: Krishnan Sampathkumar; Chi Eva Y; Webb Jonathan N; Chang Byeong S; Shan Daxian; Goldenberg Merrill; Manning Mark C; Randolph Theodore W; Carpenter John F
Aggregation of granulocyte colony stimulating factor under physiological conditions: characterization and thermodynamic inhibition.
Biochemistry 2002;41(20):6422-31.
2002: Randolph Theodore W; Seefeldt Matthew; Carpenter John F
High hydrostatic pressure as a tool to study protein aggregation and amyloidosis.
Biochimica et biophysica acta 2002;1595(1-2):224-34.
2002: Webb Serena D; Cleland Jeffrey L; Carpenter John F; Randolph Theodore W
A new mechanism for decreasing aggregation of recombinant human interferon-gamma by a surfactant: slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20.
Journal of pharmaceutical sciences 2002;91(2):543-58.
2002: Randolph Theodore W; Jones LaToya S
Surfactant-protein interactions.
Pharmaceutical biotechnology 2002;13():159-75.
2002: Carpenter John F; Chang Beyong S; Garzon-Rodriguez William; Randolph Theodore W
Rational design of stable lyophilized protein formulations: theory and practice.
Pharmaceutical biotechnology 2002;13():109-33.
2001: Webb S D; Koval C A; Randolph C M; Randolph T W
Electrochemical determination of dissolution rates of lyophilized pharmaceutical formulations.
Analytical chemistry 2001;73(21):5296-301.
2001: Jones L S; Randolph T W; Kohnert U; Papadimitriou A; Winter G; Hagmann M L; Manning M C; Carpenter J F
The effects of Tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution.
Journal of pharmaceutical sciences 2001;90(10):1466-77.
2001: Webb J N; Webb S D; Cleland J L; Carpenter J F; Randolph T W
Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: high-pressure and cosolute studies on recombinant human IFN-gamma.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7259-64.
2001: Anchordoquy T J; Izutsu K I; Randolph T W; Carpenter J F
Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying.
Archives of biochemistry and biophysics 2001;390(1):35-41.
2001: Kim Y S; Cape S P; Chi E; Raffen R; Wilkins-Stevens P; Stevens F J; Manning M C; Randolph T W; Solomon A; Carpenter J F
Counteracting effects of renal solutes on amyloid fibril formation by immunoglobulin light chains.
The Journal of biological chemistry 2001;276(2):1626-33.
2000: DePaz R A; Barnett C C; Dale D A; Carpenter J F; Gaertner A L; Randolph T W
The excluding effects of sucrose on a protein chemical degradation pathway: methionine oxidation in subtilisin.
Archives of biochemistry and biophysics 2000;384(1):123-32.
2000: Yang T H; Cleland J L; Lam X; Meyer J D; Jones L S; Randolph T W; Manning M C; Carpenter J F
Effect of zinc binding and precipitation on structures of recombinant human growth hormone and nerve growth factor.
Journal of pharmaceutical sciences 2000;89(11):1480-5.
2000: Webb J N; Carpenter J F; Randolph T W
Stability of subtilisin and lysozyme under high hydrostatic pressure.
Biotechnology progress 2000;16(4):630-6.
2000: Xu J; Heys J J; Barocas V H; Randolph T W
Permeability and diffusion in vitreous humor: implications for drug delivery.
Pharmaceutical research 2000;17(6):664-9.
2000: Allison S D; Manning M C; Randolph T W; Middleton K; Davis A; Carpenter J F
Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran.
Journal of pharmaceutical sciences 2000;89(2):199-214.
2000: Kim Y; Wall J S; Meyer J; Murphy C; Randolph T W; Manning M C; Solomon A; Carpenter J F
Thermodynamic modulation of light chain amyloid fibril formation.
The Journal of biological chemistry 2000;275(3):1570-4.
1999: St John R J; Carpenter J F; Randolph T W
High pressure fosters protein refolding from aggregates at high concentrations.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13029-33.
1999: Jones L S; Cipolla D; Liu J; Shire S J; Randolph T W
Investigation of protein-surfactant interactions by analytical ultracentrifugation and electron paramagnetic resonance: the use of recombinant human tissue factor as an example.
Pharmaceutical research 1999;16(6):808-12.
1999: Allison S D; Chang B; Randolph T W; Carpenter J F
Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding.
Archives of biochemistry and biophysics 1999;365(2):289-98.
1999: Heller M C; Carpenter J F; Randolph T W
Protein formulation and lyophilization cycle design: prevention of damage due to freeze-concentration induced phase separation.
Biotechnology and bioengineering 1999;63(2):166-74.
1999: Heller M C; Carpenter J F; Randolph T W
Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilization.
Archives of biochemistry and biophysics 1999;363(2):191-201.
1999: Kreilgaard L; Frokjaer S; Flink J M; Randolph T W; Carpenter J F
Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid.
Journal of pharmaceutical sciences 1999;88(3):281-90.
1999: Heller M C; Carpenter J F; Randolph T W
Conformational stability of lyophilized PEGylated proteins in a phase-separating system.
Journal of pharmaceutical sciences 1999;88(1):58-64.
1999: Carpenter J F; Kendrick B S; Chang B S; Manning M C; Randolph T W
Inhibition of stress-induced aggregation of protein therapeutics.
Methods in enzymology 1999;309():236-55.
1998: Kreilgaard L; Jones L S; Randolph T W; Frokjaer S; Flink J M; Manning M C; Carpenter J F
Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII.
Journal of pharmaceutical sciences 1998;87(12):1597-603.
1998: Bam N B; Cleland J L; Yang J; Manning M C; Carpenter J F; Kelley R F; Randolph T W
Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions.
Journal of pharmaceutical sciences 1998;87(12):1554-9.
1998: Kreilgaard L; Frokjaer S; Flink J M; Randolph T W; Carpenter J F
Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid.
Archives of biochemistry and biophysics 1998;360(1):121-34.
1998: Kendrick B S; Carpenter J F; Cleland J L; Randolph T W
A transient expansion of the native state precedes aggregation of recombinant human interferon-gamma.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14142-6.
1998: Allison S D; Randolph T W; Manning M C; Middleton K; Davis A; Carpenter J F
Effects of drying methods and additives on structure and function of actin: mechanisms of dehydration-induced damage and its inhibition.
Archives of biochemistry and biophysics 1998;358(1):171-81.
1998: Meyer J D; Falk R F; Kelly R M; Shively J E; Withrow S J; Dernell W S; Kroll D J; Randolph T W; Manning M C
Preparation and in vitro characterization of gentamycin-impregnated biodegradable beads suitable for treatment of osteomyelitis.
Journal of pharmaceutical sciences 1998;87(9):1149-54.
1998: Kendrick B S; Cleland J L; Lam X; Nguyen T; Randolph T W; Manning M C; Carpenter J F
Aggregation of recombinant human interferon gamma: kinetics and structural transitions.
Journal of pharmaceutical sciences 1998;87(9):1069-76.
1998: Kerwin B A; Heller M C; Levin S H; Randolph T W
Effects of Tween 80 and sucrose on acute short-term stability and long-term storage at -20 degrees C of a recombinant hemoglobin.
Journal of pharmaceutical sciences 1998;87(9):1062-8.
1998: Falk R F; Randolph T W
Process variable implications for residual solvent removal and polymer morphology in the formation of gentamycin-loaded poly (L-lactide) microparticles.
Pharmaceutical research 1998;15(8):1233-7.
1997: Randolph T W
Phase separation of excipients during lyophilization: effects on protein stability.
Journal of pharmaceutical sciences 1997;86(11):1198-203.
1997: Kendrick B S; Chang B S; Arakawa T; Peterson B; Randolph T W; Manning M C; Carpenter J F
Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: role in restricted conformational mobility and compaction of native state.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11917-22.
1997: Heller M C; Carpenter J F; Randolph T W
Manipulation of lyophilization-induced phase separation: implications for pharmaceutical proteins.
Biotechnology progress 1997;13(5):590-6.
1997: Carpenter J F; Pikal M J; Chang B S; Randolph T W
Rational design of stable lyophilized protein formulations: some practical advice.
Pharmaceutical research 1997;14(8):969-75.
1996: Heller M C; Carpenter J F; Randolph T W
Effects of phase separating systems on lyophilized hemoglobin.
Journal of pharmaceutical sciences 1996;85(12):1358-62.
1996: Bam N B; Cleland J L; Randolph T W
Molten globule intermediate of recombinant human growth hormone: stabilization with surfactants.
Biotechnology progress 1996;12(6):801-9.
1996: Izutsu K; Yoshioka S; Kojima S; Randolph T W; Carpenter J F
Effects of sugars and polymers on crystallization of poly(ethylene glycol) in frozen solutions: phase separation between incompatible polymers.
Pharmaceutical research 1996;13(9):1393-400.
1995: Bam N B; Randolph T W; Cleland J L
Stability of protein formulations: investigation of surfactant effects by a novel EPR spectroscopic technique.
Pharmaceutical research 1995;12(1):2-11.
1993: Randolph T W; Randolph A D; Mebes M; Yeung S
Sub-micrometer-sized biodegradable particles of poly(L-lactic acid) via the gas antisolvent spray precipitation process.
Biotechnology progress 1993;9(4):429-35.
1992: Cleland J L; Randolph T W
Mechanism of polyethylene glycol interaction with the molten globule folding intermediate of bovine carbonic anhydrase B.
The Journal of biological chemistry 1992;267(5):3147-53.
1990: Randolph T W
Supercritical fluid extractions in biotechnology.
Trends in biotechnology 1990;8(3):78-82.
1988: Randolph T W; Clark D S; Blanch H W; Prausnitz J M
Cholesterol aggregation and interaction with cholesterol oxidase in supercritical carbon dioxide.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):2979-83.
1988: Clark D S; Skerker P S; Randolph T W; Blanch H W; Prausnitz J M
Conformational analyses of enzymes and substrates in processing environments.
Annals of the New York Academy of Sciences 1988;542():16-29.

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