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Theodore Randolph

Research Profile

Chemicals & Drugs

Physiology

Protein Folding

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Freeze Drying

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TOP 3
Pinaki Basu; Sampathkumar Krishnan; Theodore W Randolph; Renuka Thirumangalathu; John F Carpenter
IgG1 aggregation and particle formation induced by silicone-water interfaces on siliconized borosilicate glass beads: a model for siliconized primary containers.
Alana Gerhardt; Jared S Bee; Kurt Bonam; John F Carpenter; Theodore W Randolph
Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil-water interfaces.
Danny K Chou; Rajesh Krishnamurthy; Mark C Manning; Theodore W Randolph; John F Carpenter
Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation.

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2013: Pinaki Basu; Sampathkumar Krishnan; Theodore W Randolph; Renuka Thirumangalathu; John F Carpenter
IgG1 aggregation and particle formation induced by silicone-water interfaces on siliconized borosilicate glass beads: a model for siliconized primary containers.
Journal of pharmaceutical sciences 2013;102(3):852-65.
2013: Alana Gerhardt; Jared S Bee; Kurt Bonam; John F Carpenter; Theodore W Randolph
Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil-water interfaces.
Journal of pharmaceutical sciences 2013;102(2):429-40.
2013: Danny K Chou; Rajesh Krishnamurthy; Mark C Manning; Theodore W Randolph; John F Carpenter
Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation.
Journal of pharmaceutical sciences 2013;102(2):660-73.
2012: Keith A Britt; John F Carpenter; Hanns-Christian Mahler; Daniel K Schwartz; Christine Wurth; Theodore W Randolph
Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions.
Journal of pharmaceutical sciences 2012;101(12):4419-32.
2012: Lu Liu; Theodore W Randolph; John F Carpenter
Particles shed from syringe filters and their effects on agitation-induced protein aggregation.
Journal of pharmaceutical sciences 2012;101(8):2952-9.
2012: Danny K Chou; Rajesh Krishnamurthy; Mark C Manning; Theodore W Randolph; John F Carpenter
Physical stability of albinterferon-α(2b) in aqueous solution: effects of conformational stability and colloidal stability on aggregation.
Journal of pharmaceutical sciences 2012;101(8):2702-19.
2012: Amanda A Cordes; John F Carpenter; Theodore W Randolph
Accelerated stability studies of abatacept formulations: comparison of freeze-thawing- and agitation-induced stresses.
Journal of pharmaceutical sciences 2012;101(7):2307-15.
2012: Amanda A Cordes; John F Carpenter; Theodore W Randolph
Selective domain stabilization as a strategy to reduce human serum albumin-human granulocyte colony stimulating factor aggregation rate.
Journal of pharmaceutical sciences 2012;101(6):2009-16.
2012: Amanda A Cordes; Christopher W Platt; John F Carpenter; Theodore W Randolph
Selective domain stabilization as a strategy to reduce fusion protein aggregation.
Journal of pharmaceutical sciences 2012;101(4):1400-9.
2011: Amber Haynes Fradkin; John F Carpenter; Theodore W Randolph
Glass particles as an adjuvant: a model for adverse immunogenicity of therapeutic proteins.
Journal of pharmaceutical sciences 2011;100(11):4953-64.
2011: D Brett Ludwig; Joseph T Trotter; John P Gabrielson; John F Carpenter; Theodore W Randolph
Flow cytometry: a promising technique for the study of silicone oil-induced particulate formation in protein formulations.
Analytical biochemistry 2011;410(2):191-9.
2011: Shujun Bai; Mark C Manning; Theodore W Randolph; John F Carpenter
Aggregation of recombinant human botulinum protein antigen serotype C in varying solution conditions: implications of conformational stability for aggregation kinetics.
Journal of pharmaceutical sciences 2011;100(3):836-48.
2011: James G Barnard; Satish Singh; Theodore W Randolph; John F Carpenter
Subvisible particle counting provides a sensitive method of detecting and quantifying aggregation of monoclonal antibody caused by freeze-thawing: insights into the roles of particles in the protein aggregation pathway.
Journal of pharmaceutical sciences 2011;100(2):492-503.
2011: Matthew Hoehne; Fauna Samuel; Aichun Dong; Christine Wurth; Hanns-Christian Mahler; John F Carpenter; Theodore W Randolph
Adsorption of monoclonal antibodies to glass microparticles.
Journal of pharmaceutical sciences 2011;100(1):123-32.
2010: Ryan L Crisman; Theodore W Randolph
Crystallization of recombinant human growth hormone at elevated pressures: pressure effects on PEG-induced volume exclusion interactions.
Biotechnology and bioengineering 2010;107(4):663-72.
2010: Branden A Salinas; Hasige A Sathish; Ambarish Shah; John F Carpenter; Theodore W Randolph
Buffer-dependent fragmentation of a humanized full-length monoclonal antibody.
Journal of pharmaceutical sciences 2010;99(7):2962-74.
2010: Amber Haynes Fradkin; Carl S Boand; Stephen P Eisenberg; Mary S Rosendahl; Theodore W Randolph
Recombinant murine growth hormone from E. coli inclusion bodies: expression, high-pressure solubilization and refolding, and characterization of activity and structure.
Biotechnology progress 2010;26(3):743-9.
2010: John F Carpenter; Theodore W Randolph; Wim Jiskoot; Daan J A Crommelin; C Russell Middaugh; Gerhard Winter
Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products.
Journal of pharmaceutical sciences 2010;99(5):2200-8.
2010: D Brett Ludwig; John F Carpenter; Jean-Bernard Hamel; Theodore W Randolph
Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions.
Journal of pharmaceutical sciences 2010;99(4):1721-33.
2010: Jared S Bee; Michele Davis; Erwin Freund; John F Carpenter; Theodore W Randolph
Aggregation of a monoclonal antibody induced by adsorption to stainless steel.
Biotechnology and bioengineering 2010;105(1):121-9.
2010: Branden A Salinas; Hasige A Sathish; Steven M. Bishop; Nick Harn; John F Carpenter; Theodore W Randolph
Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation.
Journal of pharmaceutical sciences 2010;99(1):82-93.
2009: Jonas Fast; Amanda A Cordes; John F Carpenter; Theodore W Randolph
Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability.
Biochemistry 2009;48(49):11724-36.
2009: Amber Haynes Fradkin; John F Carpenter; Theodore W Randolph
Immunogenicity of aggregates of recombinant human growth hormone in mouse models.
Journal of pharmaceutical sciences 2009;98(9):3247-64.
2009: Jared S Bee; David Chiu; Suzanne Sawicki; Jennifer L Stevenson; Koustuv Chatterjee; Erwin Freund; John F Carpenter; Theodore W Randolph
Monoclonal antibody interactions with micro- and nanoparticles: adsorption, aggregation, and accelerated stress studies.
Journal of pharmaceutical sciences 2009;98(9):3218-38.
2009: Jared S Bee; Stephanie A Nelson; Erwin Freund; John F Carpenter; Theodore W Randolph
Precipitation of a monoclonal antibody by soluble tungsten.
Journal of pharmaceutical sciences 2009;98(9):3290-301.
2009: Tia Estey; Christina Vessely; Theodore W Randolph; Ian Henderson; Latoya Jones Braun; Rajiv Nayar; John F Carpenter
Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry.
Journal of pharmaceutical sciences 2009;98(9):2994-3012.
2009: Christina Vessely; Tia Estey; Theodore W Randolph; Ian Henderson; Julianne Cooper; Rajiv Nayar; Latoya Jones Braun; John F Carpenter
Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution.
Journal of pharmaceutical sciences 2009;98(9):2970-93.
2009: Derrick S Katayama; John F Carpenter; Kevin P Menard; Mark C Manning; Theodore W Randolph
Mixing properties of lyophilized protein systems: a spectroscopic and calorimetric study.
Journal of pharmaceutical sciences 2009;98(9):2954-69.
2009: Jared S Bee; Jennifer L Stevenson; Bhavya Mehta; Juraj Svitel; Joey Pollastrini; Robert Platz; Erwin Freund; John F Carpenter; Theodore W Randolph
Response of a concentrated monoclonal antibody formulation to high shear.
Biotechnology and bioengineering 2009;103(5):936-43.
2009: John F Carpenter; Theodore W Randolph; Wim Jiskoot; Daan J A Crommelin; C Russell Middaugh; Gerhard Winter; Ying-Xin Fan; Susan Kirshner; Daniela Verthelyi; Steven Kozlowski; Kathleen A Clouse; Patrick G Swann; Amy Rosenberg; Barry Cherney
Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.
Journal of pharmaceutical sciences 2009;98(4):1201-5.
2009: Ryan L Crisman; Theodore W Randolph
Refolding of proteins from inclusion bodies is favored by a diminished hydrophobic effect at elevated pressures.
Biotechnology and bioengineering 2009;102(2):483-92.
2009: Amber L Clausi; Andrea Morin; John F Carpenter; Theodore W Randolph
Influence of protein conformation and adjuvant aggregation on the effectiveness of aluminum hydroxide adjuvant in a model alkaline phosphatase vaccine.
Journal of pharmaceutical sciences 2009;98(1):114-21.
2009: Anil K Tyagi; Theodore W Randolph; Aichun Dong; Kevin M Maloney; Carl Hitscherich; John F Carpenter
IgG particle formation during filling pump operation: a case study of heterogeneous nucleation on stainless steel nanoparticles.
Journal of pharmaceutical sciences 2009;98(1):94-104.
2008: Shouvik Roy; Ian Henderson; Rajiv Nayar; Theodore W Randolph; John F Carpenter
Effect of pH on stability of recombinant botulinum serotype A vaccine in aqueous solution and during storage of freeze-dried formulations.
Journal of pharmaceutical sciences 2008;97(12):5132-46.
2008: Amber Clausi; Jessica Cummiskey; Scott Merkley; John F Carpenter; Latoya Jones Braun; Theodore W Randolph
Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine.
Journal of pharmaceutical sciences 2008;97(12):5252-62.
2008: John R Alford; Stanley C Kwok; Jennifer N Roberts; Deborah S Wuttke; Brent S Kendrick; John F Carpenter; Theodore W Randolph
High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization.
Journal of pharmaceutical sciences 2008;97(8):3035-50.
2008: John R Alford; Brent S Kendrick; John F Carpenter; Theodore W Randolph
High concentration formulations of recombinant human interleukin-1 receptor antagonist: II. Aggregation kinetics.
Journal of pharmaceutical sciences 2008;97(8):3005-21.
2008: John R Alford; Brent S Kendrick; John F Carpenter; Theodore W Randolph
Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium.
Analytical biochemistry 2008;377(2):128-33.
2008: Amber L Clausi; Scott A Merkley; John F Carpenter; Theodore W Randolph
Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying.
Journal of pharmaceutical sciences 2008;97(6):2049-61.
2008: Lisa A Kueltzo; Wei Wang; Theodore W Randolph; John F Carpenter
Effects of solution conditions, processing parameters, and container materials on aggregation of a monoclonal antibody during freeze-thawing.
Journal of pharmaceutical sciences 2008;97(5):1801-12.
2008: Derrick S Katayama; John F Carpenter; Mark C Manning; Theodore W Randolph; Peter Setlow; Kevin P Menard
Characterization of amorphous solids with weak glass transitions using high ramp rate differential scanning calorimetry.
Journal of pharmaceutical sciences 2008;97(2):1013-24.
2007: Matthew B Seefeldt; Chris Crouch; Brent S Kendrick; Theodore W Randolph
Specific volume and adiabatic compressibility measurements of native and aggregated recombinant human interleukin-1 receptor antagonist: density differences enable pressure-modulated refolding.
Biotechnology and bioengineering 2007;98(2):476-85.
2007: Christina Vessely; Tia Estey; Theodore W Randolph; Ian Henderson; Rajiv Nayar; John F Carpenter
Effects of solution conditions and surface chemistry on the adsorption of three recombinant botulinum neurotoxin antigens to aluminum salt adjuvants.
Journal of pharmaceutical sciences 2007;96(9):2375-89.
2007: Renuka Thirumangalathu; Sampathkumar Krishnan; Pavel V Bondarenko; Margaret Speed-Ricci; Theodore W Randolph; John F Carpenter; David N Brems
Oxidation of methionine residues in recombinant human interleukin-1 receptor antagonist: implications of conformational stability on protein oxidation kinetics.
Biochemistry 2007;46(21):6213-24.
2007: John P Gabrielson; Theodore W Randolph; Brent S Kendrick; Michael R Stoner
Sedimentation velocity analytical ultracentrifugation and SEDFIT/c(s): limits of quantitation for a monoclonal antibody system.
Analytical biochemistry 2007;361(1):24-30.
2007: John P Gabrielson; Mark L Brader; Allen H Pekar; Kathrin B Mathis; Gerhard Winter; John F Carpenter; Theodore W Randolph
Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity.
Journal of pharmaceutical sciences 2007;96(2):268-79.
2006: Renuka Thirumangalathu; Sampathkumar Krishnan; David N Brems; Theodore W Randolph; John F Carpenter
Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factor.
Journal of pharmaceutical sciences 2006;95(7):1480-97.
2006: Shouvik Roy; Derrick S Katayama; Aichun Dong; Bruce A Kerwin; Theodore W Randolph; John F Carpenter
Temperature dependence of benzyl alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist.
Biochemistry 2006;45(12):3898-911.
2006: Seung-Hyun Lee; John F Carpenter; Byeong S Chang; Theodore W Randolph; Yong-Sung Kim
Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure.
Protein science : a publication of the Protein Society 2006;15(2):304-13.
2006: Yong-Sung Kim; Theodore W Randolph; Matthew B Seefeldt; John F Carpenter
High-pressure studies on protein aggregates and amyloid fibrils.
Methods in enzymology 2006;413():237-53.
2006: Michael R Stoner; Douglas A Dale; Peter J Gualfetti; Todd Becker; Theodore W Randolph
Surfactant-induced unfolding of cellulase: kinetic studies.
Biotechnology progress 2006;22(1):225-32.
2005: Eva Y Chi; Brent S Kendrick; John F Carpenter; Theodore W Randolph
Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist.
Journal of pharmaceutical sciences 2005;94(12):2735-48.
2005: Daniel J Jarmer; Corinne S Lengsfeld; Kristi S Anseth; Theodore W Randolph
Supercritical fluid crystallization of griseofulvin: crystal habit modification with a selective growth inhibitor.
Journal of pharmaceutical sciences 2005;94(12):2688-702.
2005: Michael R Stoner; Douglas A Dale; Peter J Gualfetti; Todd Becker; Theodore W Randolph
Ca2+-surfactant interactions affect enzyme stability in detergent solutions.
Biotechnology progress 2005;21(6):1716-23.
2005: Huiyu Zhou; Yanling Zhang; Danielle L Biggs; Mark C Manning; Theodore W Randolph; Uwe Christians; Brooks M Hybertson; Ka-yun Ng
Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages.
Journal of controlled release : official journal of the Controlled Release Society 2005;107(2):288-99.
2005: Matthew B Seefeldt; Yong-Sung Kim; Kevin P Tolley; Jim Seely; John F Carpenter; Theodore W Randolph
High-pressure studies of aggregation of recombinant human interleukin-1 receptor antagonist: thermodynamics, kinetics, and application to accelerated formulation studies.
Protein science : a publication of the Protein Society 2005;14(9):2258-66.
2005: Danny K Chou; Rajesh Krishnamurthy; Theodore W Randolph; John F Carpenter; Mark C Manning
Effects of Tween 20 and Tween 80 on the stability of Albutropin during agitation.
Journal of pharmaceutical sciences 2005;94(6):1368-81.
2005: Shouvik Roy; Rose Jung; Bruce A Kerwin; Theodore W Randolph; John F Carpenter
Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations.
Journal of pharmaceutical sciences 2005;94(2):382-96.
2005: Eva Y Chi; Joachim Weickmann; John F Carpenter; Mark C Manning; Theodore W Randolph
Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation.
Journal of pharmaceutical sciences 2005;94(2):256-74.
2004: Ye Zhang; Shouvik Roy; LaToya S Jones; Sampathkumar Krishnan; Bruce A Kerwin; Byeong S Chang; Mark C Manning; Theodore W Randolph; John F Carpenter
Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution.
Journal of pharmaceutical sciences 2004;93(12):3076-89.
2004: Matthew B Seefeldt; Jun Ouyang; Wayne A Froland; John F Carpenter; Theodore W Randolph
High-pressure refolding of bikunin: efficacy and thermodynamics.
Protein science : a publication of the Protein Society 2004;13(10):2639-50.
2004: Mayank M Patel; Michelle G Zeles; Mark C Manning; Theodore W Randolph; Thomas J Anchordoquy
Degradation kinetics of high molecular weight poly(L-lactide) microspheres and release mechanism of lipid:DNA complexes.
Journal of pharmaceutical sciences 2004;93(10):2573-84.
2004: Michael R Stoner; Norm Fischer; Lori Nixon; Scott Buckel; Mark Benke; Fred Austin; Theodore W Randolph; Brent S Kendrick
Protein-solute interactions affect the outcome of ultrafiltration/diafiltration operations.
Journal of pharmaceutical sciences 2004;93(9):2332-42.
2004: Daniel J Jarmer; Corinne S Lengsfeld; Theodore W Randolph
Nucleation and growth rates of poly(L-lactic acid) microparticles during precipitation with a compressed-fluid antisolvent.
Langmuir : the ACS journal of surfaces and colloids 2004;20(17):7254-64.
2004: William Garzon-Rodriguez; Rebecca L Koval; Suchart Chongprasert; Sampathkumar Krishnan; Theodore W Randolph; Nicholas Warne; John F Carpenter
Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures.
Journal of pharmaceutical sciences 2004;93(3):684-96.
2003: Danielle L Biggs; Corinne S Lengsfeld; Brooks M Hybertson; Ka-yun Ng; Mark C Manning; Theodore W Randolph
In vitro and in vivo evaluation of the effects of PLA microparticle crystallinity on cellular response.
Journal of controlled release : official journal of the Controlled Release Society 2003;92(1-2):147-61.
2003: Eva Y Chi; Sampathkumar Krishnan; Theodore W Randolph; John F Carpenter
Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation.
Pharmaceutical research 2003;20(9):1325-36.
2003: Yong-Sung Kim; LaToya S Jones; Aichun Dong; Brent S Kendrick; Byeong S Chang; Mark C Manning; Theodore W Randolph; John F Carpenter
Effects of sucrose on conformational equilibria and fluctuations within the native-state ensemble of proteins.
Protein science : a publication of the Protein Society 2003;12(6):1252-61.
2003: Eva Y Chi; Sampathkumar Krishnan; Brent S Kendrick; Byeong S Chang; John F Carpenter; Theodore W Randolph
Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor.
Protein science : a publication of the Protein Society 2003;12(5):903-13.
2003: Serena D Webb; Jeffrey L Cleland; John F Carpenter; Theodore W Randolph
Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma.
Journal of pharmaceutical sciences 2003;92(4):715-29.
2003: Yong-Sung Kim; Theodore W Randolph; Mark C Manning; Fred J Stevens; John F Carpenter
Congo red populates partially unfolded states of an amyloidogenic protein to enhance aggregation and amyloid fibril formation.
The Journal of biological chemistry 2003;278(12):10842-50.
2003: Sampathkumar Krishnan; Eva Y Chi; Stephen J Wood; Brent S Kendrick; Cynthia Li; William Garzon-Rodriguez; Jette Wypych; Theodore W Randolph; Linda O Narhi; Anja Leona Biere; Martin Citron; John F Carpenter
Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.
Biochemistry 2003;42(3):829-37.
2003: Matthew S Stay; Jing Xu; Theodore W Randolph; Victor H Barocas
Computer simulation of convective and diffusive transport of controlled-release drugs in the vitreous humor.
Pharmaceutical research 2003;20(1):96-102.
2002: Corinne S Lengsfeld; D Pitera; M Manning; Theodore W Randolph
Dissolution and partitioning behavior of hydrophobic ion-paired compounds.
Pharmaceutical research 2002;19(10):1572-6.
2002: Corinne S Lengsfeld; Mark C Manning; Theodore W Randolph
Encapsulating DNA within biodegradable polymeric microparticles.
Current pharmaceutical biotechnology 2002;3(3):227-35.
2002: Yong-Sung Kim; Theodore W Randolph; Fred J Stevens; John F Carpenter
Kinetics and energetics of assembly, nucleation, and growth of aggregates and fibrils for an amyloidogenic protein. Insights into transition states from pressure, temperature, and co-solute studies.
The Journal of biological chemistry 2002;277(30):27240-6.
2002: Huiyu Zhou; Corinne S Lengsfeld; David J Claffey; James A Ruth; Brooks M Hybertson; Theodore W Randolph; Ka-yun Ng; Mark C Manning
Hydrophobic ion pairing of isoniazid using a prodrug approach.
Journal of pharmaceutical sciences 2002;91(6):1502-11.
2002: Serena D Webb; Stephen L Golledge; Jeffrey L Cleland; John F Carpenter; Theodore W Randolph
Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations.
Journal of pharmaceutical sciences 2002;91(6):1474-87.
2002: Sampathkumar Krishnan; Eva Y Chi; Jonathan N Webb; Byeong S Chang; Daxian Shan; Merrill Goldenberg; Mark C Manning; Theodore W Randolph; John F Carpenter
Aggregation of granulocyte colony stimulating factor under physiological conditions: characterization and thermodynamic inhibition.
Biochemistry 2002;41(20):6422-31.
2002: Richard J St John; John F Carpenter; Theodore W Randolph
High-pressure refolding of disulfide-cross-linked lysozyme aggregates: thermodynamics and optimization.
Biotechnology progress 2002;18(3):565-71.
2002: Theodore W Randolph; Matthew B Seefeldt; John F Carpenter
High hydrostatic pressure as a tool to study protein aggregation and amyloidosis.
Biochimica et biophysica acta 2002;1595(1-2):224-34.
2002: Serena D Webb; Jeffrey L Cleland; John F Carpenter; Theodore W Randolph
A new mechanism for decreasing aggregation of recombinant human interferon-gamma by a surfactant: slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20.
Journal of pharmaceutical sciences 2002;91(2):543-58.
2002: Theodore W Randolph; LaToya S Jones
Surfactant-protein interactions.
Pharmaceutical biotechnology 2002;13():159-75.
2002: John F Carpenter; Byeong S Chang; William Garzon-Rodriguez; Theodore W Randolph
Rational design of stable lyophilized protein formulations: theory and practice.
Pharmaceutical biotechnology 2002;13():109-33.
2001: Serena D Webb; C A Koval; C M Randolph; Theodore W Randolph
Electrochemical determination of dissolution rates of lyophilized pharmaceutical formulations.
Analytical chemistry 2001;73(21):5296-301.
2001: LaToya S Jones; Theodore W Randolph; U Kohnert; A Papadimitriou; G Winter; M L Hagmann; Mark C Manning; John F Carpenter
The effects of Tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution.
Journal of pharmaceutical sciences 2001;90(10):1466-77.
2001: Jonathan N Webb; Serena D Webb; Jeffrey L Cleland; John F Carpenter; Theodore W Randolph
Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: high-pressure and cosolute studies on recombinant human IFN-gamma.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7259-64.
2001: Thomas J Anchordoquy; K I Izutsu; Theodore W Randolph; John F Carpenter
Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying.
Archives of biochemistry and biophysics 2001;390(1):35-41.
2001: Yong-Sung Kim; S P Cape; Eva Y Chi; Rosemarie Raffen; P Wilkins-Stevens; Fred J Stevens; Mark C Manning; Theodore W Randolph; Alan Solomon; John F Carpenter
Counteracting effects of renal solutes on amyloid fibril formation by immunoglobulin light chains.
The Journal of biological chemistry 2001;276(2):1626-33.
2000: R A DePaz; C C Barnett; Douglas A Dale; John F Carpenter; Alfred L Gaertner; Theodore W Randolph
The excluding effects of sucrose on a protein chemical degradation pathway: methionine oxidation in subtilisin.
Archives of biochemistry and biophysics 2000;384(1):123-32.
2000: TH Yang; Jeffrey L Cleland; XM Lam; Jeffrey D Meyer; LaToya S Jones; Theodore W Randolph; Mark C Manning; John F Carpenter
Effect of zinc binding and precipitation on structures of recombinant human growth hormone and nerve growth factor.
Journal of pharmaceutical sciences 2000;89(11):1480-5.
2000: Jonathan N Webb; John F Carpenter; Theodore W Randolph
Stability of subtilisin and lysozyme under high hydrostatic pressure.
Biotechnology progress 2000;16(4):630-6.
2000: J Xu; Jeffrey J Heys; Victor H Barocas; Theodore W Randolph
Permeability and diffusion in vitreous humor: implications for drug delivery.
Pharmaceutical research 2000;17(6):664-9.
2000: SD Allison; Mark C Manning; Theodore W Randolph; K Middleton; A Davis; John F Carpenter
Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran.
Journal of pharmaceutical sciences 2000;89(2):199-214.
2000: Y Kim; Jonathan S. Wall; J Meyer; C Murphy; Theodore W Randolph; Mark C Manning; Alan Solomon; John F Carpenter
Thermodynamic modulation of light chain amyloid fibril formation.
The Journal of biological chemistry 2000;275(3):1570-4.
1999: R J St John; John F Carpenter; Theodore W Randolph
High pressure fosters protein refolding from aggregates at high concentrations.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13029-33.
1999: LaToya S Jones; D Cipolla; Jubo Liu; S J Shire; Theodore W Randolph
Investigation of protein-surfactant interactions by analytical ultracentrifugation and electron paramagnetic resonance: the use of recombinant human tissue factor as an example.
Pharmaceutical research 1999;16(6):808-12.
1999: SD Allison; B Chang; Theodore W Randolph; John F Carpenter
Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding.
Archives of biochemistry and biophysics 1999;365(2):289-98.
1999: MC Heller; John F Carpenter; Theodore W Randolph
Protein formulation and lyophilization cycle design: prevention of damage due to freeze-concentration induced phase separation.
Biotechnology and bioengineering 1999;63(2):166-74.
1999: MC Heller; John F Carpenter; Theodore W Randolph
Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilization.
Archives of biochemistry and biophysics 1999;363(2):191-201.
1999: L Kreilgaard; Sven Frokjaer; James M Flink; Theodore W Randolph; John F Carpenter
Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid.
Journal of pharmaceutical sciences 1999;88(3):281-90.
1999: John F Carpenter; Brent S Kendrick; Byeong S Chang; Mark C Manning; Theodore W Randolph
Inhibition of stress-induced aggregation of protein therapeutics.
Methods in enzymology 1999;309():236-55.
1999: MC Heller; John F Carpenter; Theodore W Randolph
Conformational stability of lyophilized PEGylated proteins in a phase-separating system.
Journal of pharmaceutical sciences 1999;88(1):58-64.
1998: L Kreilgaard; LaToya S Jones; Theodore W Randolph; Sven Frokjaer; James M Flink; Mark C Manning; John F Carpenter
Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII.
Journal of pharmaceutical sciences 1998;87(12):1597-603.
1998: N B Bam; Jeffrey L Cleland; J Yang; Mark C Manning; John F Carpenter; R F Kelley; Theodore W Randolph
Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions.
Journal of pharmaceutical sciences 1998;87(12):1554-9.
1998: L Kreilgaard; Sven Frokjaer; James M Flink; Theodore W Randolph; John F Carpenter
Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid.
Archives of biochemistry and biophysics 1998;360(1):121-34.
1998: Brent S Kendrick; John F Carpenter; Jeffrey L Cleland; Theodore W Randolph
A transient expansion of the native state precedes aggregation of recombinant human interferon-gamma.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14142-6.
1998: SD Allison; Theodore W Randolph; Mark C Manning; K Middleton; A Davis; John F Carpenter
Effects of drying methods and additives on structure and function of actin: mechanisms of dehydration-induced damage and its inhibition.
Archives of biochemistry and biophysics 1998;358(1):171-81.
1998: Jeffrey D Meyer; R F Falk; RM Kelly; J E Shively; S J Withrow; W S Dernell; David Kroll; Theodore W Randolph; Mark C Manning
Preparation and in vitro characterization of gentamycin-impregnated biodegradable beads suitable for treatment of osteomyelitis.
Journal of pharmaceutical sciences 1998;87(9):1149-54.
1998: Brent S Kendrick; Jeffrey L Cleland; XM Lam; T Nguyen; Theodore W Randolph; Mark C Manning; John F Carpenter
Aggregation of recombinant human interferon gamma: kinetics and structural transitions.
Journal of pharmaceutical sciences 1998;87(9):1069-76.
1998: Bruce A Kerwin; MC Heller; S H Levin; Theodore W Randolph
Effects of Tween 80 and sucrose on acute short-term stability and long-term storage at -20 degrees C of a recombinant hemoglobin.
Journal of pharmaceutical sciences 1998;87(9):1062-8.
1998: R F Falk; Theodore W Randolph
Process variable implications for residual solvent removal and polymer morphology in the formation of gentamycin-loaded poly (L-lactide) microparticles.
Pharmaceutical research 1998;15(8):1233-7.
1997: Theodore W Randolph
Phase separation of excipients during lyophilization: effects on protein stability.
Journal of pharmaceutical sciences 1997;86(11):1198-203.
1997: Brent S Kendrick; Byeong S Chang; T Arakawa; B Peterson; Theodore W Randolph; Mark C Manning; John F Carpenter
Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: role in restricted conformational mobility and compaction of native state.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11917-22.
1997: MC Heller; John F Carpenter; Theodore W Randolph
Manipulation of lyophilization-induced phase separation: implications for pharmaceutical proteins.
Biotechnology progress 1997;13(5):590-6.
1997: John F Carpenter; M J Pikal; B S Chang; Theodore W Randolph
Rational design of stable lyophilized protein formulations: some practical advice.
Pharmaceutical research 1997;14(8):969-75.
1996: MC Heller; John F Carpenter; Theodore W Randolph
Effects of phase separating systems on lyophilized hemoglobin.
Journal of pharmaceutical sciences 1996;85(12):1358-62.
1996: N B Bam; Jeffrey L Cleland; Theodore W Randolph
Molten globule intermediate of recombinant human growth hormone: stabilization with surfactants.
Biotechnology progress 1996;12(6):801-9.
1996: K Izutsu; Sumie Yoshioka; Shigeo Kojima; Theodore W Randolph; John F Carpenter
Effects of sugars and polymers on crystallization of poly(ethylene glycol) in frozen solutions: phase separation between incompatible polymers.
Pharmaceutical research 1996;13(9):1393-400.
1995: N B Bam; Theodore W Randolph; Jeffrey L Cleland
Stability of protein formulations: investigation of surfactant effects by a novel EPR spectroscopic technique.
Pharmaceutical research 1995;12(1):2-11.
1993: Theodore W Randolph; A D Randolph; M Mebes; S Yeung
Sub-micrometer-sized biodegradable particles of poly(L-lactic acid) via the gas antisolvent spray precipitation process.
Biotechnology progress 1993;9(4):429-35.
1992: Jeffrey L Cleland; Theodore W Randolph
Mechanism of polyethylene glycol interaction with the molten globule folding intermediate of bovine carbonic anhydrase B.
The Journal of biological chemistry 1992;267(5):3147-53.
1990: Theodore W Randolph
Supercritical fluid extractions in biotechnology.
Trends in biotechnology 1990;8(3):78-82.
1988: Theodore W Randolph; Douglas S Clark; Harvey W Blanch; John M Prausnitz
Cholesterol aggregation and interaction with cholesterol oxidase in supercritical carbon dioxide.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):2979-83.
1988: Douglas S Clark; P S Skerker; Theodore W Randolph; Harvey W Blanch; John M Prausnitz
Conformational analyses of enzymes and substrates in processing environments.
Annals of the New York Academy of Sciences 1988;542():16-29.