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Richard Ransohoff

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Richard M Ransohoff; Marco Prinz
Editors' preface: Microglia--A new era dawns.
Meizhang Li; Richard M Ransohoff; Jeremy Rich; James S Hale; Justin D Lathia
Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair.
Richard M Ransohoff; Britta Engelhardt
The anatomical and cellular basis of immune surveillance in the central nervous system.

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All Publications

2013: Richard M Ransohoff; Marco Prinz
Editors' preface: Microglia--A new era dawns.
Glia 2013;61(1):1-2.
2012: Meizhang Li; Richard M Ransohoff; Jeremy Rich; James S Hale; Justin D Lathia
Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair.
Trends in neurosciences 2012;35(10):619-28.
2012: Richard M Ransohoff; Britta Engelhardt
The anatomical and cellular basis of immune surveillance in the central nervous system.
Nature reviews. Immunology 2012;12(9):623-35.
2012: Richard M Ransohoff
Animal models of multiple sclerosis: the good, the bad and the bottom line.
Nature neuroscience 2012;15(8):1074-7.
2012: Yukio Takeshita; Richard M Ransohoff
Inflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro models.
Immunological reviews 2012;248(1):228-39.
2012: Zizhen Kang; Muhammet Fatih Gulen; Liping Liu; Wenjun Ouyang; Richard M Ransohoff; Roo Spangler; Charles Spear; Mike Veenstra; Chenhui Wang; Xiaoxia Li
IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(24):8284-92.
2012: Mike Veenstra; Richard M Ransohoff
Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller?
Journal of neuroimmunology 2012;246(1-2):1-9.
2012: Richard M Ransohoff
Perspective: Let the sunshine in!
Nature 2012;484(7393):S8.
2012: Shumei Man; anne cotleur; Judith Drazba; Yukio Takeshita; Barbara Tucky; Richard M Ransohoff
CXCL12-induced monocyte-endothelial interactions promote lymphocyte transmigration across an in vitro blood-brain barrier.
Science translational medicine 2012;4(119):119ra14.
2012: Richard M Ransohoff
Illuminating neuromyelitis optica pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(4):1001-2.
2012: Carine Savarin; Stephen A Stohlman; Daniel J Cua; David R Hinton; Richard M Ransohoff; Cornelia C Bergmann
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils.
Journal of neuroinflammation 2012;9():104.
2011: Joana A Zula; Holly C Green; Richard M Ransohoff; Richard A Rudick; George R Stark; Anette H H van Boxel-Dezaire
The role of cell type-specific responses in IFN-β therapy of multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(49):19689-94.
2011: Carine Savarin; Stephen A Stohlman; Niranjan Butchi; Richard M Ransohoff; Anna M Rietsch; Cornelia C Bergmann
MMP9 deficiency does not decrease blood-brain barrier disruption, but increases astrocyte MMP3 expression during viral encephalomyelitis.
Glia 2011;59(11):1770-81.
2011: Haiyan Lu; Richard M Ransohoff; Danping Huang; Lan Zhou
Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(10):3344-55.
2011: Richard M Ransohoff; Beth Stevens
Neuroscience. How many cell types does it take to wire a brain?
Science (New York, N.Y.) 2011;333(6048):1391-2.
2011: Richard M Ransohoff
Microglia and monocytes: 'tis plain the twain meet in the brain.
Nature neuroscience 2011;14(9):1098-100.
2011: Dustin J Donnelly; Kristina A Kigerl; Wenmin Lai; Erin E Longbrake; Richard M Ransohoff; Todd M Shawler; C Amy Tovar; Phillip Popovich
Deficient CX3CR1 signaling promotes recovery after mouse spinal cord injury by limiting the recruitment and activation of Ly6Clo/iNOS+ macrophages.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(27):9910-22.
2011: Cristina P Marques; Stephen L Nutt; Timothy W Phares; Richard M Ransohoff; Stephen A Stohlman; Claudia Hindinger; David R Hinton; Parul Kapil; Cornelia C Bergmann
CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis.
Journal of virology 2011;85(13):6136-47.
2011: J Javier Provencio; Tamer Altay; Saksith Smithason; Shari Korday Moore; Richard M Ransohoff
Depletion of Ly6G/C(+) cells ameliorates delayed cerebral vasospasm in subarachnoid hemorrhage.
Journal of neuroimmunology 2011;232(1-2):94-100.
2011: Ping Huang; Georgiana Cheng; Haiyan Lu; Mark Aronica; Richard M Ransohoff; Lan Zhou
Impaired respiratory function in mdx and mdx/utrn(+/-) mice.
Muscle & nerve 2011;43(2):263-7.
2011: Richard A Rudick; M R Sandhya Rani; Yaomin Xu; Jar-Chi Lee; Jie Na; Jennifer Shrock; Anupama Josyula; Elizabeth Fisher; Richard M Ransohoff
Excessive biologic response to IFNβ is associated with poor treatment response in patients with multiple sclerosis.
PloS one 2011;6(5):e19262.
2011: Meizhang Li; Cathleen J Chang; Justin D Lathia; Li Wang; Holly L Pacenta; anne cotleur; Richard M Ransohoff
Chemokine receptor CXCR4 signaling modulates the growth factor-induced cell cycle of self-renewing and multipotent neural progenitor cells.
Glia 2011;59(1):108-18.
2011: Haiyan Lu; Danping Huang; Noah Saederup; Israel F Charo; Richard M Ransohoff; Lan Zhou
Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(1):358-69.
2010: Richard M Ransohoff; Astrid E Cardona
The myeloid cells of the central nervous system parenchyma.
Nature 2010;468(7321):253-62.
2010: Sungho Lee; Nicholas H Varvel; Megan E Konerth; Guixiang Xu; Astrid E Cardona; Richard M Ransohoff; Bruce Lamb
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
The American journal of pathology 2010;177(5):2549-62.
2010: Kiran Bhaskar; Megan Konerth; Olga N Kokiko-Cochran; Astrid E Cardona; Richard M Ransohoff; Bruce T Lamb
Regulation of tau pathology by the microglial fractalkine receptor.
Neuron 2010;68(1):19-31.
2010: Flavia Trettel; Silvia Di Angelantonio; Cristina Limatola; Richard M Ransohoff
Chemokines and chemokine receptors in the nervous system. Rome, 24/25 October, 2009, 2nd workshop.
Journal of neuroimmunology 2010;224(1-2):1-7.
2010: Richard M Ransohoff
Turning over the Chance card on MS susceptibility.
Nature immunology 2010;11(7):570-2.
2010: Eisuke Sato; H Elizabeth Shick; Richard M Ransohoff; Keiko Hirose
Expression of fractalkine receptor CX3CR1 on cochlear macrophages influences survival of hair cells following ototoxic injury.
Journal of the Association for Research in Otolaryngology : JARO 2010;11(2):223-34.
2010: J Javier Provencio; X Fu; A Siu; P A Rasmussen; S L Hazen; Richard M Ransohoff
CSF neutrophils are implicated in the development of vasospasm in subarachnoid hemorrhage.
Neurocritical care 2010;12(2):244-51.
2010: Zizhen Kang; Cengiz Z Altuntas; Muhammet Fatih Gulen; Caini Liu; Natalia Giltiay; Hongwei Qin; Liping Liu; Wen Qian; Richard M Ransohoff; Cornelia Bergmann; Stephen Stohlman; Vincent K Tuohy; Xiaoxia Li
Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis.
Immunity 2010;32(3):414-25.
2010: Liping Liu; Abdelmadjid Belkadi; Lindsey Darnall; Taofang Hu; Caitlin Drescher; Anne C Cotleur; Dolly Padovani-Claudio; Tao He; Karen Choi; Thomas E Lane; Robert H Miller; Richard M Ransohoff
CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis.
Nature neuroscience 2010;13(3):319-26.
2010: Richard M Ransohoff
PML risk and natalizumab: more questions than answers.
Lancet neurology 2010;9(3):231-3.
2010: M R Sandhya Rani; Ed Croze; Tao Wei; Jennifer Shrock; Anupama Josyula; Dhan V Kalvakolanu; Richard M Ransohoff
STAT-phosphorylation-independent induction of interferon regulatory factor-9 by interferon-beta.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010;30(3):163-70.
2009: M R Sandhya Rani; Yaomin Xu; Jar-Chi Lee; Jennifer Shrock; Anupama Josyula; Joerg Schlaak; Swathi Chakraborthy; Nie Ja; Richard M Ransohoff; Richard A Rudick
Heterogeneous, longitudinally stable molecular signatures in response to interferon-beta.
Annals of the New York Academy of Sciences 2009;1182():58-68.
2009: David B Shultz; M R Sandhya Rani; John D Fuller; Richard M Ransohoff; George R Stark
Roles of IKK-beta, IRF1, and p65 in the activation of chemokine genes by interferon-gamma.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2009;29(12):817-24.
2009: Richard M Ransohoff
Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology.
Immunity 2009;31(5):711-21.
2009: Tamer Altay; Saksith Smithason; Nina Volokh; Peter A Rasmussen; Richard M Ransohoff; J Javier Provencio
A novel method for subarachnoid hemorrhage to induce vasospasm in mice.
Journal of neuroscience methods 2009;183(2):136-40.
2009: Richard M Ransohoff
Natalizumab, multiple sclerosis, and primary central nervous system lymphoma: enigma, wrapped in mystery, enclosed in conundrum.
Annals of neurology 2009;66(3):259-61.
2009: Ping Huang; Xinyu S Zhao; Matthew Fields; Richard M Ransohoff; Lan Zhou
Imatinib attenuates skeletal muscle dystrophy in mdx mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2539-48.
2009: Richard A Rudick; A Pace; M R S Rani; R Hyde; M Panzara; S Appachi; J Shrock; S L Maurer; Peter A Calabresi; C Confavreux; S L Galetta; F D Lublin; E-W Radue; Richard M Ransohoff
Effect of statins on clinical and molecular responses to intramuscular interferon beta-1a.
Neurology 2009;72(23):1989-93.
2009: Shumei Man; Barbara Tucky; Nika Bagheri; Xiaolong Li; Rabina Kochar; Richard M Ransohoff
alpha4 Integrin/FN-CS1 mediated leukocyte adhesion to brain microvascular endothelial cells under flow conditions.
Journal of neuroimmunology 2009;210(1-2):92-9.
2009: Meizhang Li; Richard M Ransohoff
The roles of chemokine CXCL12 in embryonic and brain tumor angiogenesis.
Seminars in cancer biology 2009;19(2):111-5.
2009: Richard M Ransohoff; V Hugh Perry
Microglial physiology: unique stimuli, specialized responses.
Annual review of immunology 2009;27():119-45.
2009: Natalia M Moll; Michael B Cossoy; Elizabeth Fisher; Susan M Staugaitis; Barbara H Tucky; Anna M Rietsch; Ansi Chang; Robert J Fox; Bruce D Trapp; Richard M Ransohoff
Imaging correlates of leukocyte accumulation and CXCR4/CXCL12 in multiple sclerosis.
Archives of neurology 2009;66(1):44-53.
2008: Carine Savarin; Cornelia C Bergmann; David R Hinton; Richard M Ransohoff; Stephen A Stohlman
Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis.
Journal of virology 2008;82(24):12432-40.
2008: Astrid E Cardona; Meizhang Li; Liping Liu; Carine Savarin; Richard M Ransohoff
Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation.
Journal of leukocyte biology 2008;84(3):587-94.
2008: Se Hoon Choi; Karthikeyan Veeraraghavalu; Orly Lazarov; Seoan Marler; Richard M Ransohoff; Jan-Marino Ramirez; Sangram S Sisodia
Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
Neuron 2008;59(4):568-80.
2008: Flavia Trettel; Silvia Di Angelantonio; Cristina Limatola; Richard M Ransohoff
Chemokines and chemokine receptors in the nervous system Rome, 27/28 October, 2007.
Journal of neuroimmunology 2008;198(1-2):1-8.
2008: John H Noseworthy; Robert A Gross; Andrew G Engel; Karen C Johnston; David S. Knopman; Jonathan W Mink; Richard M Ransohoff; Ryan Uitti
Translating research into treatments.
Neurology 2008;71(4):232-3.
2008: Astrid E Cardona; Margaret E Sasse; Liping Liu; Sandra M Cardona; Makiko Mizutani; Carine Savarin; Taofang Hu; Richard M Ransohoff
Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues.
Blood 2008;112(2):256-63.
2008: Ying Bai; Ruolan Liu; DeRen Huang; Antonio La Cava; Yi-yuan Tang; Yoichiro Iwakura; Denise I Campagnolo; Timothy L Vollmer; Richard M Ransohoff; Fu-Dong Shi
CCL2 recruitment of IL-6-producing CD11b+ monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity.
European journal of immunology 2008;38(7):1877-88.
2008: Florian Eichler; Jia-Qian Ren; Michael Cossoy; Anna M Rietsch; Sameer Nagpal; Ann B Moser; Matthew P Frosch; Richard M Ransohoff
Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?
Annals of neurology 2008;63(6):729-42.
2008: Richard A Rudick; Richard M Ransohoff
Biomarkers for interferon response in MS: are we there yet?
Neurology 2008;70(13 Pt 2):1069-70.
2008: Eisuke Sato; H Elizabeth Shick; Richard M Ransohoff; Keiko Hirose
Repopulation of cochlear macrophages in murine hematopoietic progenitor cell chimeras: the role of CX3CR1.
The Journal of comparative neurology 2008;506(6):930-42.
2008: Meizhang Li; Richard M Ransohoff
Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology.
Progress in neurobiology 2008;84(2):116-31.
2008: N M Moll; A M Rietsch; A J Ransohoff; M B Cossoy; DeRen Huang; F S Eichler; Bruce D Trapp; Richard M Ransohoff
Cortical demyelination in PML and MS: Similarities and differences.
Neurology 2008;70(5):336-43.
2008: Lan Zhou; Jill A Rafael-Fortney; Ping Huang; Xinyu S Zhao; Georgiana Cheng; Xiaohua Zhou; Henry Kaminski; Liping Liu; Richard M Ransohoff
Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice.
Journal of the neurological sciences 2008;264(1-2):106-11.
2008: Shumei Man; Eroboghene E Ubogu; Katherine A Williams; Barbara Tucky; Melissa K Callahan; Richard M Ransohoff
Human brain microvascular endothelial cells and umbilical vein endothelial cells differentially facilitate leukocyte recruitment and utilize chemokines for T cell migration.
Clinical & developmental immunology 2008;2008():384982.
2007: Ernest C Borden; Ganes C Sen; Gilles Uze; Robert H Silverman; Richard M Ransohoff; Graham R Foster; George R Stark
Interferons at age 50: past, current and future impact on biomedicine.
Nature reviews. Drug discovery 2007;6(12):975-90.
2007: Richard M Ransohoff
Microgliosis: the questions shape the answers.
Nature neuroscience 2007;10(12):1507-9.
2007: M R Sandhya Rani; Jennifer Shrock; Swathi Appachi; Richard A Rudick; Bryan R G Williams; Richard M Ransohoff
Novel interferon-beta-induced gene expression in peripheral blood cells.
Journal of leukocyte biology 2007;82(5):1353-60.
2007: Carine Savarin-Vuaillat; Richard M Ransohoff
Chemokines and chemokine receptors in neurological disease: raise, retain, or reduce?
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2007;4(4):590-601.
2007: M R Sandhya Rani; Sudha Pandalai; Jennifer Shrock; alex almasan; Richard M Ransohoff
Requirement of catalytically active Tyk2 and accessory signals for the induction of TRAIL mRNA by IFN-beta.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(9):767-79.
2007: Richard M Ransohoff
"Thinking without thinking" about natalizumab and PML.
Journal of the neurological sciences 2007;259(1-2):50-2.
2007: DeRen Huang; Michael Cossoy; Meizhang Li; Dean Choi; Alan J Taege; Susan M Staugaitis; Susan Rehm; Richard M Ransohoff
Inflammatory progressive multifocal leukoencephalopathy in human immunodeficiency virus-negative patients.
Annals of neurology 2007;62(1):34-9.
2007: Richard M Ransohoff
Natalizumab for multiple sclerosis.
The New England journal of medicine 2007;356(25):2622-9.
2007: Shumei Man; Eroboghene E Ubogu; Richard M Ransohoff
Inflammatory cell migration into the central nervous system: a few new twists on an old tale.
Brain pathology (Zurich, Switzerland) 2007;17(2):243-50.
2007: Bruce D Trapp; Jerome R Wujek; Gerson A Criste; Walid Jalabi; Xinghua Yin; Grahame J Kidd; Stephen A Stohlman; Richard M Ransohoff
Evidence for synaptic stripping by cortical microglia.
Glia 2007;55(4):360-8.
2007: Richard M Ransohoff; Liping Liu; Astrid E Cardona
Chemokines and chemokine receptors: multipurpose players in neuroinflammation.
International review of neurobiology 2007;82():187-204.
2006: Nathan B Sautter; Elizabeth H Shick; Richard M Ransohoff; Israel F Charo; Keiko Hirose
CC chemokine receptor 2 is protective against noise-induced hair cell death: studies in CX3CR1(+/GFP) mice.
Journal of the Association for Research in Otolaryngology : JARO 2006;7(4):361-72.
2006: Natalia M Rebenko-Moll; Liping Liu; Astrid E Cardona; Richard M Ransohoff
Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details.
Current opinion in immunology 2006;18(6):683-9.
2006: Eroboghene E Ubogu; Melissa K Callahan; Barbara Tucky; Richard M Ransohoff
Determinants of CCL5-driven mononuclear cell migration across the blood-brain barrier. Implications for therapeutically modulating neuroinflammation.
Journal of neuroimmunology 2006;179(1-2):132-44.
2006: Eroboghene E Ubogu; Melissa K Callahan; Barbara Tucky; Richard M Ransohoff
CCR5 expression on monocytes and T cells: modulation by transmigration across the blood-brain barrier in vitro.
Cellular immunology 2006;243(1):19-29.
2006: Richard M Ransohoff
A mighty mouse: building a better model of multiple sclerosis.
The Journal of clinical investigation 2006;116(9):2313-6.
2006: LiPing Liu; Gerard J Graham; Anita Damodaran; Taofang Hu; sergio lira; Margaret E Sasse; Claudia Canasto-Chibuque; Donald N Cook; Richard M Ransohoff
Cutting edge: the silent chemokine receptor D6 is required for generating T cell responses that mediate experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):17-21.
2006: Astrid E Cardona; Erik P Pioro; Margaret E Sasse; Volodymyr Kostenko; Sandra M Cardona; Ineke M Dijkstra; Deren Huang; Grahame J Kidd; Stephen Dombrowski; Ranjan Dutta; Jar-Chi Lee; Donald N Cook; Steffen Jung; sergio lira; Dan R Littman; Richard M Ransohoff
Control of microglial neurotoxicity by the fractalkine receptor.
Nature neuroscience 2006;9(7):917-24.
2006: DeRen Huang; Fu-Dong Shi; Steffen Jung; Gary C Pien; Jintang Wang; Thais P Salazar-Mather; Toby T He; Jennifer T Weaver; Hans-Gustaf Ljunggren; Christine A Biron; Dan R Littman; Richard M Ransohoff
The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):896-905.
2006: Liping Liu; Deren Huang; Masaru Matsui; Toby T He; Taofang Hu; Julie Demartino; Bao Lu; Craig Gerard; Richard M Ransohoff
Severe disease, unaltered leukocyte migration, and reduced IFN-gamma production in CXCR3-/- mice with experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4399-409.
2006: Astrid E Cardona; DeRen Huang; Margaret E Sasse; Richard M Ransohoff
Isolation of murine microglial cells for RNA analysis or flow cytometry.
Nature protocols 2006;1(4):1947-51.
2006: Robert J Fox; Pia Kivisäkk; Jar-Chi Lee; Barbara Tucky; Claudia F Lucchinetti; Richard A Rudick; Richard M Ransohoff
Chemokine receptors as biomarkers in multiple sclerosis.
Disease markers 2006;22(4):227-33.
2006: Pia Kivisäkk; Barbara Tucky; Tao Wei; James J Campbell; Richard M Ransohoff
Human cerebrospinal fluid contains CD4+ memory T cells expressing gut- or skin-specific trafficking determinants: relevance for immunotherapy.
BMC immunology 2006;7():14.
2006: Eroboghene E Ubogu; Michael B Cossoy; Richard M Ransohoff
The expression and function of chemokines involved in CNS inflammation.
Trends in pharmacological sciences 2006;27(1):48-55.
2006: Don J Mahad; Melissa K Callahan; Katherine A Williams; Eroboghene E Ubogu; Pia Kivisäkk; Barbara Tucky; Grahame J Kidd; Gillian A Kingsbury; Ansi Chang; Robert J Fox; Matthias Mack; M Bradley Sniderman; Rivka Ravid; Susan M Staugaitis; Monique F Stins; Richard M Ransohoff
Modulating CCR2 and CCL2 at the blood-brain barrier: relevance for multiple sclerosis pathogenesis.
Brain : a journal of neurology 2006;129(Pt 1):212-23.
2005: M R Sandhya Rani; Richard M Ransohoff
Alternative and accessory pathways in the regulation of IFN-beta-mediated gene expression.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2005;25(12):788-98.
2005: Orhun H Kantarci; Yazmín Morales; Patricia A Ziemer; David D Hebrink; Don J Mahad; Elizabeth J Atkinson; Sara J Achenbach; Mariza de Andrade; Matthias Mack; Richard M Ransohoff; Hans Lassmann; Wolfgang Bruck; Brian G Weinshenker; Claudia F Lucchinetti
CCR5Delta32 polymorphism effects on CCR5 expression, patterns of immunopathology and disease course in multiple sclerosis.
Journal of neuroimmunology 2005;169(1-2):137-43.
2005: Tim Wehner; Jeffrey S Ross; Richard M Ransohoff
Fluid in the flute: Reversible hydromyelia.
Journal of the neurological sciences 2005;236(1-2):85-6.
2005: Keiko Hirose; Christopher M Discolo; Jodi R Keasler; Richard M Ransohoff
Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma.
The Journal of comparative neurology 2005;489(2):180-94.
2005: Andrzej R Glabinski; Marcin Jalosinski; Richard M Ransohoff
Chemokines and chemokine receptors in inflammation of the CNS.
Expert review of clinical immunology 2005;1(2):293-301.
2005: J Javier Provencio; Pia Kivisäkk; Barbara Tucky; Mark G Luciano; Richard M Ransohoff
Comparison of ventricular and lumbar cerebrospinal fluid T cells in non-inflammatory neurological disorder (NIND) patients.
Journal of neuroimmunology 2005;163(1-2):179-84.
2005: Richard M Ransohoff; Bruce D Trapp
Taking two TRAILS.
Neuron 2005;46(3):355-6.
2005: Deren Huang; Jerome R Wujek; Grahame J Kidd; Toby T He; Astrid E Cardona; Margaret E Sasse; Erica J Stein; Jacqueline Kish; Marie Tani; Israel F Charo; Amanda E Proudfoot; Barrett J Rollins; Tracy Handel; Richard M Ransohoff
Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):761-72.
2005: Don J Mahad; Susan M Staugaitis; Paul M Ruggieri; Joseph E Parisi; BK Kleinschmidt-DeMasters; Hans Lassmann; Richard M Ransohoff
Steroid-responsive encephalopathy associated with autoimmune thyroiditis and primary CNS demyelination.
Journal of the neurological sciences 2005;228(1):3-5.
2005: Liping Liu; Melissa K Callahan; DeRen Huang; Richard M Ransohoff
Chemokine receptor CXCR3: an unexpected enigma.
Current topics in developmental biology 2005;68():149-81.
2004: Robert J Fox; Richard M Ransohoff
New directions in MS therapeutics: vehicles of hope.
Trends in immunology 2004;25(12):632-6.
2004: Richard A Rudick; Jar-Chi Lee; Jack Simon; Richard M Ransohoff; Elizabeth Fisher
Defining interferon beta response status in multiple sclerosis patients.
Annals of neurology 2004;56(4):548-55.
2004: Andrzej R Glabinski; Bartosz Bielecki; Julie A Kawczak; Vincent K Tuohy; Krzysztof Selmaj; Richard M Ransohoff
Treatment with soluble tumor necrosis factor receptor (sTNFR):Fc/p80 fusion protein ameliorates relapsing-remitting experimental autoimmune encephalomyelitis and decreases chemokine expression.
Autoimmunity 2004;37(6-7):465-71.
2004: Melissa K Callahan; Katherine A Williams; Pia Kivisäkk; Donna Pearce; Monique F Stins; Richard M Ransohoff
CXCR3 marks CD4+ memory T lymphocytes that are competent to migrate across a human brain microvascular endothelial cell layer.
Journal of neuroimmunology 2004;153(1-2):150-7.
2004: Manhong Ma; Ping Wei; Tao Wei; Richard M Ransohoff; Lyn B Jakeman
Enhanced axonal growth into a spinal cord contusion injury site in a strain of mouse (129X1/SvJ) with a diminished inflammatory response.
The Journal of comparative neurology 2004;474(4):469-86.
2004: Torben Lykke Sørensen; Richard M Ransohoff; Robert M Strieter; Finn Sellebjerg
Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2004;11(7):445-9.
2004: Nywana Sizemore; Anju Agarwal; Kingshuk Das; Natalia Lerner; Michael Sulak; Sandhya Rani; Richard M Ransohoff; David Shultz; George R Stark
Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7994-8.
2004: Pia Kivisäkk; Don J Mahad; Melissa K Callahan; Keith Sikora; Corinna Trebst; Barbara Tucky; Jerome R Wujek; Rivka Ravid; Susan M Staugaitis; Hans Lassmann; Richard M Ransohoff
Expression of CCR7 in multiple sclerosis: implications for CNS immunity.
Annals of neurology 2004;55(5):627-38.
2004: Don J Mahad; Corinna Trebst; Pia Kivisäkk; Susan M Staugaitis; Barbara Tucky; Tao Wei; Claudia F Lucchinetti; Hans Lassmann; Richard M Ransohoff
Expression of chemokine receptors CCR1 and CCR5 reflects differential activation of mononuclear phagocytes in pattern II and pattern III multiple sclerosis lesions.
Journal of neuropathology and experimental neurology 2004;63(3):262-73.
2004: Don J Mahad; Corinna Trebst; Susan M Staugaitis; Pia Kivisäkk; Barbara Tucky; Tao Wei; Richard Horuk; Richard M Ransohoff
Preliminary observations on CC chemokine receptor expression by mononuclear phagocytes in multiple sclerosis lesions: effect of lesion heterogeneity.
Ernst Schering Research Foundation workshop 2004;(45):59-68.
2004: Melissa K Callahan; Richard M Ransohoff
Analysis of leukocyte extravasation across the blood-brain barrier: conceptual and technical aspects.
Current allergy and asthma reports 2004;4(1):65-73.
2003: Corinna Trebst; Susan M Staugaitis; Barbara Tucky; Tao Wei; K Suzuki; Kenneth Aldape; CARLOS PARDO-VILLAMIZAR; Juan C Troncoso; Hans Lassmann; Richard M Ransohoff
Chemokine receptors on infiltrating leucocytes in inflammatory pathologies of the central nervous system (CNS).
Neuropathology and applied neurobiology 2003;29(6):584-95.
2003: Gurunathan Murugesan; M R Sandhya Rani; Christina E Gerber; Chaitali Mukhopadhyay; Richard M Ransohoff; Guy M Chisolm; Kandice Kottke-Marchant
Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines.
Journal of molecular and cellular cardiology 2003;35(11):1375-84.
2003: Andrzej R Glabinski; Bartosz Bielecki; Pawel Kolodziejski; Yulong Han; Krzysztof Selmaj; Richard M Ransohoff
TNF-alpha microinjection upregulates chemokines and chemokine receptors in the central nervous system without inducing leukocyte infiltration.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2003;23(8):457-66.
2003: Pia Kivisäkk; anne cotleur; Jar-Chi Lee; Richard A Rudick; Richard M Ransohoff
Interferon-beta 1a does not reduce expression of CCR5 and CXCR3 on circulating T cells.
Journal of neuroimmunology 2003;141(1-2):150-4.
2003: Pia Kivisäkk; Don J Mahad; Melissa K Callahan; Corinna Trebst; Barbara Tucky; Tao Wei; Lijun Wu; Espen S Baekkevold; Hans Lassmann; Susan M Staugaitis; James J Campbell; Richard M Ransohoff
Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8389-94.
2003: Richard M Ransohoff; Pia Kivisäkk; Grahame J Kidd
Three or more routes for leukocyte migration into the central nervous system.
Nature reviews. Immunology 2003;3(7):569-81.
2003: Andrzej R Glabinski; Bartosz Bielecki; Richard M Ransohoff
Chemokine upregulation follows cytokine expression in chronic relapsing experimental autoimmune encephalomyelitis.
Scandinavian journal of immunology 2003;58(1):81-8.
2003: Pia Kivisäkk; Corinna Trebst; Jar-Chi Lee; Barbara Tucky; Richard A Rudick; James J Campbell; Richard M Ransohoff
Expression of CCR2, CCR5, and CXCR3 by CD4+ T cells is stable during a 2-year longitudinal study but varies widely between individuals.
Journal of neurovirology 2003;9(3):291-9.
2003: Pia Kivisäkk; Zhugong Liu; Corinna Trebst; Barbara Tucky; Lijun Wu; Johnny Stine; Matthias Mack; Richard A Rudick; James J Campbell; Richard M Ransohoff
Flow cytometric analysis of chemokine receptor expression on cerebrospinal fluid leukocytes.
Methods (San Diego, Calif.) 2003;29(4):319-25.
2003: Torben Lykke Sørensen; Richard M Ransohoff; J Jensen; Finn Sellebjerg
Evidence favoring the involvement of CC chemokine receptor (CCR) 5 in T-lymphocyte accumulation in optic neuritis.
Acta neurologica Scandinavica 2003;107(3):221-7.
2003: Corinna Trebst; Susan M Staugaitis; Pia Kivisäkk; Don J Mahad; Martha K Cathcart; Barbara Tucky; Tao Wei; Mysore R Sandhya Rani; Richard Horuk; Kenneth Aldape; CARLOS PARDO-VILLAMIZAR; Claudia F Lucchinetti; Hans Lassmann; Richard M Ransohoff
CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages.
The American journal of pathology 2003;162(2):427-38.
2003: Don J Mahad; Richard M Ransohoff
The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
Seminars in immunology 2003;15(1):23-32.
2003: Kevin Pavelko; Charles Howe; Kristen Drescher; Jeff Gamez; Aaron J Johnson; Tao Wei; Richard M Ransohoff; Moses Rodriguez
Interleukin-6 protects anterior horn neurons from lethal virus-induced injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(2):481-92.
2002: DeRen Huang; Marie Tani; Jintang Wang; Yulong Han; Toby T He; Jennifer Weaver; Israel F Charo; Vincent K Tuohy; Barrett J Rollins; Richard M Ransohoff
Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(24):10633-42.
2002: Andrzej R Glabinski; Bartosz Bielecki; Sage O'Bryant; Krzysztof Selmaj; Richard M Ransohoff
Experimental autoimmune encephalomyelitis: CC chemokine receptor expression by trafficking cells.
Journal of autoimmunity 2002;19(4):175-81.
2002: Richard M Ransohoff
The chemokine system in neuroinflammation: an update.
The Journal of infectious diseases 2002;186 Suppl 2():S152-6.
2002: M R Sandhya Rani; Linda Hibbert; Nywana Sizemore; George R Stark; Richard M Ransohoff
Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene.
The Journal of biological chemistry 2002;277(41):38456-61.
2002: Pia Kivisäkk; Corinna Trebst; Zhugong Liu; Barbara Tucky; Torben Lykke Sørensen; Richard A Rudick; Matthias Mack; Richard M Ransohoff
T-cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking.
Clinical and experimental immunology 2002;129(3):510-8.
2002: Masaru Matsui; Jennifer Weaver; Amanda E I Proudfoot; Jerome R Wujek; Tao Wei; Edward Richer; Bruce D Trapp; Ashwin Rao; Richard M Ransohoff
Treatment of experimental autoimmune encephalomyelitis with the chemokine receptor antagonist Met-RANTES.
Journal of neuroimmunology 2002;128(1-2):16-22.
2002: Claudia F Lucchinetti; Raul N Mandler; Dorian B McGavern; Wolfgang Bruck; Gerald Gleich; Richard M Ransohoff; Corinna Trebst; Brian G Weinshenker; Dean M Wingerchuk; Joseph E Parisi; Hans Lassmann
A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.
Brain : a journal of neurology 2002;125(Pt 7):1450-61.
2002: Manhong Ma; Tao Wei; Landin Boring; Israel F Charo; Richard M Ransohoff; Lyn B Jakeman
Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion.
Journal of neuroscience research 2002;68(6):691-702.
2002: John W Peterson; Lars Bö; Sverre Mörk; Ansi Chang; Richard M Ransohoff; Bruce D Trapp
VCAM-1-positive microglia target oligodendrocytes at the border of multiple sclerosis lesions.
Journal of neuropathology and experimental neurology 2002;61(6):539-46.
2002: Torben Lykke Sørensen; Corinna Trebst; Pia Kivisäkk; Karen L Klaege; Amit Majmudar; Rivka Ravid; Hans Lassmann; David B Olsen; Robert M Strieter; Richard M Ransohoff; Finn Sellebjerg
Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system.
Journal of neuroimmunology 2002;127(1-2):59-68.
2002: Bernd C Kieseier; Marie Tani; Don J Mahad; Nobuyuki Oka; Ho W Tony; Nicola Woodroofe; John W Griffin; Klaus V Toyka; Richard M Ransohoff; Hans-Peter Hartung
Chemokines and chemokine receptors in inflammatory demyelinating neuropathies: a central role for IP-10.
Brain : a journal of neurology 2002;125(Pt 4):823-34.
2002: Richard M Ransohoff; Tao Wei; Kevin Pavelko; J-C Lee; Paul D Murray; Moses Rodriguez
Chemokine expression in the central nervous system of mice with a viral disease resembling multiple sclerosis: roles of CD4+ and CD8+ T cells and viral persistence.
Journal of virology 2002;76(5):2217-24.
2002: T Charis Wagner; Sharlene Velichko; David Vogel; M R Sandhya Rani; Stewart Leung; Richard M Ransohoff; George R Stark; H Daniel Perez; Ed Croze
Interferon signaling is dependent on specific tyrosines located within the intracellular domain of IFNAR2c. Expression of IFNAR2c tyrosine mutants in U5A cells.
The Journal of biological chemistry 2002;277(2):1493-9.
2002: Corinna Trebst; Torben Lykke Sørensen; Pia Kivisäkk; Martha K Cathcart; Joseph Hesselgesser; Richard Horuk; Finn Sellebjerg; Hans Lassmann; Richard M Ransohoff
Chemokine receptors on mononuclear phagocytes in the central nervous system of patients with multiple sclerosis.
Ernst Schering Research Foundation workshop 2002;(39):193-211.
2002: Jerome R Wujek; Carl Bjartmar; Edward Richer; Richard M Ransohoff; Min Yu; Vincent K Tuohy; Bruce D Trapp
Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis.
Journal of neuropathology and experimental neurology 2002;61(1):23-32.
2001: A R Glabinsk; Richard M Ransohoff
Targeting the chemokine system for multiple sclerosis treatment.
Current opinion in investigational drugs (London, England : 2000) 2001;2(12):1712-9.
2001: M R Sandhya Rani; A R Asthagiri; A Singh; Nywana Sizemore; Swati S Sathe; Xiaoxia Li; J D DiDonato; George R Stark; Richard M Ransohoff
A role for NF-kappa B in the induction of beta-R1 by interferon-beta.
The Journal of biological chemistry 2001;276(48):44365-8.
2001: Torben Lykke Sørensen; Finn Sellebjerg; CV Jensen; Robert M Strieter; Richard M Ransohoff
Chemokines CXCL10 and CCL2: differential involvement in intrathecal inflammation in multiple sclerosis.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2001;8(6):665-72.
2001: Pia Kivisäkk; Corinna Trebst; D J Eckstein; A P Kerza-Kwiatecki; Richard M Ransohoff
Chemokine-based therapies for MS: how do we get there from here?
Trends in immunology 2001;22(11):591-3.
2001: Corinna Trebst; Torben Lykke Sørensen; Pia Kivisäkk; Martha K Cathcart; Joseph Hesselgesser; Richard Horuk; Finn Sellebjerg; Hans Lassmann; Richard M Ransohoff
CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis.
The American journal of pathology 2001;159(5):1701-10.
2001: Yulong Han; T He; D R Huang; CARLOS PARDO-VILLAMIZAR; Richard M Ransohoff
TNF-alpha mediates SDF-1 alpha-induced NF-kappa B activation and cytotoxic effects in primary astrocytes.
The Journal of clinical investigation 2001;108(3):425-35.
2001: chilakamarti ramana; M Pilar Gil; Yulong Han; Richard M Ransohoff; Robert D Schreiber; George R Stark
Stat1-independent regulation of gene expression in response to IFN-gamma.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6674-9.
2001: D R Huang; Jintang Wang; P Kivisakk; Barrett J Rollins; Richard M Ransohoff
Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2001;193(6):713-26.
2001: Z H Zhou; Y Han; T Wei; S Aras; P Chaturvedi; S Tyler; M R Rani; Richard M Ransohoff
Regulation of monocyte chemoattractant protein (MCP)-1 transcription by interferon-gamma (IFN-gamma) in human astrocytoma cells: postinduction refractory state of the gene, governed by its upstream elements.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):383-92.
2001: Jing Gao; Bishnu P De; Yulong Han; Suresh Choudhary; Richard M Ransohoff; Amiya Banerja
Human parainfluenza virus type 3 inhibits gamma interferon-induced major histocompatibility complex class II expression directly and by inducing alpha/beta interferon.
Journal of virology 2001;75(3):1124-31.
2001: Yulong Han; Jintang Wang; T He; Richard M Ransohoff
TNF-alpha down-regulates CXCR4 expression in primary murine astrocytes.
Brain research 2001;888(1):1-10.
2000: D Sun; Marie Tani; Tracey A Newman; KA Krivacic; M Phillips; AL Chernosky; P Gill; Tao Wei; K J Griswold; Richard M Ransohoff; Roy O Weller
Role of chemokines, neuronal projections, and the blood-brain barrier in the enhancement of cerebral EAE following focal brain damage.
Journal of neuropathology and experimental neurology 2000;59(12):1031-43.
2000: Bernd C Kieseier; K Krivacic; S Jung; Heidrun Pischel; Klaus V Toyka; Richard M Ransohoff; Hans-Peter Hartung
Sequential expression of chemokines in experimental autoimmune neuritis.
Journal of neuroimmunology 2000;110(1-2):121-9.
2000: D Huang; Y Han; M R Rani; Andrzej R Glabinski; Corinna Trebst; T Sørensen; Marie Tani; J Wang; P Chien; S O'Bryan; Bartosz Bielecki; Z L Zhou; S Majumder; Richard M Ransohoff
Chemokines and chemokine receptors in inflammation of the nervous system: manifold roles and exquisite regulation.
Immunological reviews 2000;177():52-67.
2000: D Russell-Harde; T Charis Wagner; M R Sandhya Rani; David Vogel; Oscar R Colamonici; Richard M Ransohoff; Beata Majchrzak; Eleanor N Fish; H Daniel Perez; Ed Croze
Role of the intracellular domain of the human type I interferon receptor 2 chain (IFNAR2c) in interferon signaling. Expression of IFNAR2c truncation mutants in U5A cells.
The Journal of biological chemistry 2000;275(31):23981-5.
2000: Richard M Ransohoff; Corinna Trebst
Surprising pleiotropy of nerve growth factor in the treatment of experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2000;191(10):1625-30.
2000: Paul D Murray; KA Krivacic; AL Chernosky; Tao Wei; Richard M Ransohoff; Moses Rodriguez
Biphasic and regionally-restricted chemokine expression in the central nervous system in the Theiler's virus model of multiple sclerosis.
Journal of neurovirology 2000;6 Suppl 1():S44-52.
2000: Q Wu; R H Miller; Richard M Ransohoff; S Robinson; J Bu; A Nishiyama
Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(7):2609-17.
2000: Gurunathan Murugesan; M R Rani; Richard M Ransohoff; Roger E Marchant; Kandice Kottke-Marchant
Endothelial cell expression of monocyte chemotactic protein-1, tissue factor, and thrombomodulin on hydrophilic plasma polymers.
Journal of biomedical materials research 2000;49(3):396-408.
2000: Y Han; Jintang Wang; Z Zhou; Richard M Ransohoff
TGFbeta1 selectively up-regulates CCR1 expression in primary murine astrocytes.
Glia 2000;30(1):1-10.
2000: Andrzej R Glabinski; S O'Bryant; Krzysztof Selmaj; Richard M Ransohoff
CXC chemokine receptors expression during chronic relapsing experimental autoimmune encephalomyelitis.
Annals of the New York Academy of Sciences 2000;917():135-44.
1999: Andrzej R Glabinski; Richard M Ransohoff
Sentries at the gate: chemokines and the blood-brain barrier.
Journal of neurovirology 1999;5(6):623-34.
1999: M R Sandhya Rani; Douglas W Leaman; Yulong Han; Stewart Leung; Ed Croze; Eleanor N Fish; Alan Wolfman; Richard M Ransohoff
Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase.
The Journal of biological chemistry 1999;274(45):32507-11.
1999: Kazutoshi Nishiyama; Bruce D Trapp; T Ikezu; Richard M Ransohoff; Taisuke Tomita; Takeshi Iwatsubo; I Kanazawa; Karen K. Hsiao Ashe; Michael P Lisanti; T Okamoto
Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(15):6538-48.
1999: Yulong Han; N Rogers; Richard M Ransohoff
Tumor necrosis factor-alpha signals to the IFN-gamma receptor complex to increase Stat1alpha activation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(7):731-40.
1999: Richard M Ransohoff
Mechanisms of inflammation in MS tissue: adhesion molecules and chemokines.
Journal of neuroimmunology 1999;98(1):57-68.
1999: Bruce D Trapp; Richard M Ransohoff; Richard A Rudick
Axonal pathology in multiple sclerosis: relationship to neurologic disability.
Current opinion in neurology 1999;12(3):295-302.
1999: VA Folcik; Terence Smith; S O'Bryant; Julie A Kawczak; B Zhu; H Sakurai; A Kajiwara; James M Staddon; Andrzej R Glabinski; AL Chernosky; Marie Tani; Justin M Johnson; Vincent K Tuohy; Lee L Rubin; Richard M Ransohoff
Treatment with BBB022A or rolipram stabilizes the blood-brain barrier in experimental autoimmune encephalomyelitis: an additional mechanism for the therapeutic effect of type IV phosphodiesterase inhibitors.
Journal of neuroimmunology 1999;97(1-2):119-28.
1999: Torben Lykke Sørensen; Marie Tani; J Jensen; V Pierce; Claudia F Lucchinetti; VA Folcik; S Qin; J Rottman; Finn Sellebjerg; Robert M Strieter; Jette Lautrup Frederiksen; Richard M Ransohoff
Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients.
The Journal of clinical investigation 1999;103(6):807-15.
1999: Andrzej R Glabinski; ML Krakowski; Y Han; Trevor Owens; Richard M Ransohoff
Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis.
Journal of neurovirology 1999;5(1):95-101.
1999: Andrzej R Glabinski; Richard M Ransohoff
Chemokines and chemokine receptors in CNS pathology.
Journal of neurovirology 1999;5(1):3-12.
1999: M R Sandhya Rani; C Gauzzi; S Pellegrini; Eleanor N Fish; T Wei; Richard M Ransohoff
Induction of beta-R1/I-TAC by interferon-beta requires catalytically active TYK2.
The Journal of biological chemistry 1999;274(4):1891-7.
1999: Richard A Rudick; Diane L Cookfair; Nancy Simonian; Richard M Ransohoff; John R Richert; Lawrence D Jacobs; Robert M Herndon; AM Salazar; Jill Fischer; CV Granger; Donald Goodkin; Jack H Simon; DM Bartoszak; Dennis N Bourdette; J Braiman; Carol Brownscheidle; Michael E Coats; Stanley L Cohan; DS Dougherty; R Philip Kinkel; Michele K Mass; F E Munchsauer; K O'Reilly; Roger Priore; Ruth H Whitham
Cerebrospinal fluid abnormalities in a phase III trial of Avonex (IFNbeta-1a) for relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group.
Journal of neuroimmunology 1999;93(1-2):8-14.
1998: S Majumder; L Z Zhou; P Chaturvedi; G Babcock; S Aras; Richard M Ransohoff
p48/STAT-1alpha-containing complexes play a predominant role in induction of IFN-gamma-inducible protein, 10 kDa (IP-10) by IFN-gamma alone or in synergy with TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4736-44.
1998: S Majumder; L Z Zhou; P Chaturvedi; G Babcock; S Aras; Richard M Ransohoff
Regulation of human IP-10 gene expression in astrocytoma cells by inflammatory cytokines.
Journal of neuroscience research 1998;54(2):169-80.
1998: Dana M McTigue; M Tani; KA Krivacic; AL Chernosky; GS Kelner; D Maciejewski; R Maki; Richard M Ransohoff; Bradford T Stokes
Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury.
Journal of neuroscience research 1998;53(3):368-76.
1998: Andrzej R Glabinski; Vincent K Tuohy; Richard M Ransohoff
Expression of chemokines RANTES, MIP-1alpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitis.
Neuroimmunomodulation 1998;5(3-4):166-71.
1998: Richard A Rudick; Richard M Ransohoff; Jar-Chi Lee; R Peppler; Min Yu; PM Mathisen; Vincent K Tuohy
In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis.
Neurology 1998;50(5):1294-300.
1998: Z H Zhou; P Chaturvedi; Y L Han; S Aras; Y S Li; Pappachan Kolattukudy; D Ping; Jeremy M Boss; Richard M Ransohoff
IFN-gamma induction of the human monocyte chemoattractant protein (hMCP)-1 gene in astrocytoma cells: functional interaction between an IFN-gamma-activated site and a GC-rich element.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):3908-16.
1998: Richard M Ransohoff; Marie Tani
Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation?
Trends in neurosciences 1998;21(4):154-9.
1998: Bruce D Trapp; J Peterson; Richard M Ransohoff; Richard A Rudick; Sverre Mörk; Lars Bö
Axonal transection in the lesions of multiple sclerosis.
The New England journal of medicine 1998;338(5):278-85.
1998: Torben Lykke Sørensen; Richard M Ransohoff
Etiology and pathogenesis of multiple sclerosis.
Seminars in neurology 1998;18(3):287-94.
1997: Richard A Rudick; J A Cohen; Bianca Weinstock-Guttman; R Philip Kinkel; Richard M Ransohoff
Management of multiple sclerosis.
The New England journal of medicine 1997;337(22):1604-11.
1997: Richard M Ransohoff
Chemokines in neurological disease models: correlation between chemokine expression patterns and inflammatory pathology.
Journal of leukocyte biology 1997;62(5):645-52.
1997: Andrzej R Glabinski; Marie Tani; Robert M Strieter; Vincent K Tuohy; Richard M Ransohoff
Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis.
The American journal of pathology 1997;150(2):617-30.
1997: Andrzej R Glabinski; Marie Tani; Vincent K Tuohy; Richard M Ransohoff
Murine experimental autoimmune encephalomyelitis: a model of immune-mediated inflammation and multiple sclerosis.
Methods in enzymology 1997;288():182-90.
1997: Richard M Ransohoff; Marie Tani; Andrzej R Glabinski; AL Chernosky; KA Krivacic; J W Peterson; H F Chien; Bruce D Trapp
Chemokines and chemokine receptors in model neurological pathologies: molecular and immunocytochemical approaches.
Methods in enzymology 1997;287():319-48.
1996: Richard A Rudick; Richard M Ransohoff; R Peppler; S VanderBrug Medendorp; P Lehmann; J Alam
Interferon beta induces interleukin-10 expression: relevance to multiple sclerosis.
Annals of neurology 1996;40(4):618-27.
1996: Lars Bö; J W Peterson; Sverre Mork; Patricia A Hoffman; W M Gallatin; Richard M Ransohoff; Bruce D Trapp
Distribution of immunoglobulin superfamily members ICAM-1, -2, -3, and the beta 2 integrin LFA-1 in multiple sclerosis lesions.
Journal of neuropathology and experimental neurology 1996;55(10):1060-72.
1996: S Majumder; L Z Zhou; Richard M Ransohoff
Transcriptional regulation of chemokine gene expression in astrocytes.
Journal of neuroscience research 1996;45(6):758-69.
1996: M R Sandhya Rani; G R Foster; Stewart Leung; Douglas W Leaman; George R Stark; Richard M Ransohoff
Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha.
The Journal of biological chemistry 1996;271(37):22878-84.
1996: Marie Tani; M E Fuentes; J W Peterson; Bruce D Trapp; S K Durham; J K Loy; R Bravo; Richard M Ransohoff; sergio lira
Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes.
The Journal of clinical investigation 1996;98(2):529-39.
1996: P Shrikant; S J Lee; I Kalvakolanu; Richard M Ransohoff; Etty N Benveniste
Stimulus-specific inhibition of intracellular adhesion molecule-1 gene expression by TGF-beta.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(2):892-900.
1996: Richard M Ransohoff; Andrzej R Glabinski; Marie Tani
Chemokines in immune-mediated inflammation of the central nervous system.
Cytokine & growth factor reviews 1996;7(1):35-46.
1996: Andrzej R Glabinski; V Balasingam; M Tani; Steven Kunkel; R M Strieter; V Wee Yong; Richard M Ransohoff
Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(11):4363-8.
1996: Marie Tani; Andrzej R Glabinski; Vincent K Tuohy; M H Stoler; ML Estes; Richard M Ransohoff
In situ hybridization analysis of glial fibrillary acidic protein mRNA reveals evidence of biphasic astrocyte activation during acute experimental autoimmune encephalomyelitis.
The American journal of pathology 1996;148(3):889-96.
1995: Andrzej R Glabinski; Marie Tani; Vincent K Tuohy; R J Tuthill; Richard M Ransohoff
Central nervous system chemokine mRNA accumulation follows initial leukocyte entry at the onset of acute murine experimental autoimmune encephalomyelitis.
Brain, behavior, and immunity 1995;9(4):315-30.
1995: H T Lu; J L Riley; G T Babcock; M Huston; George R Stark; Jeremy M Boss; Richard M Ransohoff
Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma.
The Journal of experimental medicine 1995;182(5):1517-25.
1995: Bianca Weinstock-Guttman; Jeffrey S Ross; Richard M Ransohoff
Unusual long-standing Gd-DTPA enhancement in a chronic progressive myelopathy.
Journal of computer assisted tomography 1995;19(4):649-51.
1995: Andrzej R Glabinski; M Tani; S Aras; M H Stoler; Vincent K Tuohy; Richard M Ransohoff
Regulation and function of central nervous system chemokines.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1995;13(3-4):153-65.
1995: S J Rosenman; P Shrikant; L Dubb; Etty N Benveniste; Richard M Ransohoff
Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(4):1888-99.
1995: Bianca Weinstock-Guttman; Richard M Ransohoff; R Philip Kinkel; Richard A Rudick
The interferons: biological effects, mechanisms of action, and use in multiple sclerosis.
Annals of neurology 1995;37(1):7-15.
1994: Richard M Ransohoff; Vincent K Tuohy; P Lehmann
The immunology of multiple sclerosis: new intricacies and new insights.
Current opinion in neurology 1994;7(3):242-9.
1994: Marie Tani; Richard M Ransohoff
Do chemokines mediate inflammatory cell invasion of the central nervous system parenchyma?
Brain pathology (Zurich, Switzerland) 1994;4(2):135-43.
1993: Richard A Rudick; C S Carpenter; Diane L Cookfair; Vincent K Tuohy; Richard M Ransohoff
In vitro and in vivo inhibition of mitogen-driven T-cell activation by recombinant interferon beta.
Neurology 1993;43(10):2080-7.
1993: C Devajyothi; I Kalvakolanu; G T Babcock; H A Vasavada; Philip H Howe; Richard M Ransohoff
Inhibition of interferon-gamma-induced major histocompatibility complex class II gene transcription by interferon-beta and type beta 1 transforming growth factor in human astrocytoma cells. Definition of cis-element.
The Journal of biological chemistry 1993;268(25):18794-800.
1993: Richard M Ransohoff; Thomas Hamilton; Marie Tani; M H Stoler; H E Shick; J A Major; ML Estes; D M Thomas; Vincent K Tuohy
Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(6):592-600.
1993: Donald Goodkin; Richard A Rudick; R Philip Kinkel; Richard M Ransohoff
Corticosteroids and optic neuritis.
Neurology 1993;43(3 Pt 1):631-2; author reply 633-4.
1992: Richard M Ransohoff; Vincent K Tuohy; Barbara P Barna; Richard A Rudick
Monocytes in active multiple sclerosis: intact regulation of HLA-DR density in vitro despite decreased HLA-DR density in vivo.
Journal of neuroimmunology 1992;37(3):169-76.
1991: Richard M Ransohoff; C Devajyothi; ML Estes; G Babcock; Richard A Rudick; E M Frohman; Barbara P Barna
Interferon-beta specifically inhibits interferon-gamma-induced class II major histocompatibility complex gene transcription in a human astrocytoma cell line.
Journal of neuroimmunology 1991;33(2):103-12.
1990: Barbara P Barna; ML Estes; B S Jacobs; S Hudson; Richard M Ransohoff
Human astrocytes proliferate in response to tumor necrosis factor alpha.
Journal of neuroimmunology 1990;30(2-3):239-43.
1990: ML Estes; Richard M Ransohoff; J T McMahon; B S Jacobs; Barbara P Barna
Characterization of adult human astrocytes derived from explant culture.
Journal of neuroscience research 1990;27(4):697-705.
1990: Richard M Ransohoff; Gary J Whitman; M A Weinstein
Noncommunicating syringomyelia in multiple sclerosis: detection by magnetic resonance imaging.
Neurology 1990;40(4):718-21.
1989: M Chez; Cathy A Sila; Richard M Ransohoff; David L Longworth; C Weida
Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.
Neurology 1989;39(12):1578-80.
1989: Barbara P Barna; S M Chou; B Jacobs; Belinda Yen-Lieberman; Richard M Ransohoff
Interferon-beta impairs induction of HLA-DR antigen expression in cultured adult human astrocytes.
Journal of neuroimmunology 1989;23(1):45-53.
1989: Richard M Ransohoff
Regulation of class II major histocompatibility complex genes: relation to multiple sclerosis.
Research in immunology 1989;140(2):202-7; discussion 245-8.