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Markus Rapedius

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Markus Rapedius; Mark S P Sansom; Matthias R Schmidt; Chetan Sharma; Phillip J Stansfeld; Thomas Baukrowitz; Stephen J Tucker
State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.
Paula L Piechotta; Markus Rapedius; Mark S P Sansom; Phillip J Stansfeld; Stephen J Tucker; Gunter Ehrlich; Murali K Bollepalli; Niels Decher; Gunter Erhlich; Hariolf Fritzenschaft; Isabelle Andres-Enguix; Thomas Baukrowitz
The pore structure and gating mechanism of K2P channels.
Markus Reichold; Anselm A Zdebik; Evelyn Lieberer; Markus Rapedius; Katharina Schmidt; Sascha Bandulik; Christina Sterner; Ines Tegtmeier; David Penton; Thomas Baukrowitz; Sally-Anne Hulton; Ralph Witzgall; Bruria Ben-Zeev; Alexander J Howie; Robert Kleta; Detlef Bockenhauer; Richard Warth
KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function.

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All Publications

2012: Markus Rapedius; Mark S P Sansom; Matthias R Schmidt; Chetan Sharma; Phillip J Stansfeld; Thomas Baukrowitz; Stephen J Tucker
State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.
Channels (Austin, Tex.) 2012;6(6):473-8.
2011: Paula L Piechotta; Markus Rapedius; Mark S P Sansom; Phillip J Stansfeld; Stephen J Tucker; Gunter Ehrlich; Murali K Bollepalli; Niels Decher; Gunter Erhlich; Hariolf Fritzenschaft; Isabelle Andres-Enguix; Thomas Baukrowitz
The pore structure and gating mechanism of K2P channels.
The EMBO journal 2011;30(17):3607-19.
2010: Markus Reichold; Anselm A Zdebik; Evelyn Lieberer; Markus Rapedius; Katharina Schmidt; Sascha Bandulik; Christina Sterner; Ines Tegtmeier; David Penton; Thomas Baukrowitz; Sally-Anne Hulton; Ralph Witzgall; Bruria Ben-Zeev; Alexander J Howie; Robert Kleta; Detlef Bockenhauer; Richard Warth
KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14490-5.
2010: Niels Decher; Anne K Streit; Markus Rapedius; Michael F Netter; Stefanie Marzian; Petra Ehling; Günter Schlichthörl; Tobias Craan; Vijay Renigunta; Annemarie Köhler; Richard C Dodel; Ricardo A Navarro-Polanco; Regina Preisig-Müller; Gerhard Klebe; Thomas Budde; Thomas Baukrowitz; Jürgen Daut
RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels.
The EMBO journal 2010;29(13):2101-13.
2010: Xiantao Li; Markus Rapedius; Thomas Baukrowitz; Gong Xin Liu; D K Srivastava; Jürgen Daut; Peter J Hanley
5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches.
Biochimica et biophysica acta 2010;1800(3):385-91.
2010: Harley T Kurata; Markus Rapedius; Marc J Kleinman; Thomas Baukrowitz; Colin G Nichols
Voltage-dependent gating in a "voltage sensor-less" ion channel.
PLoS biology 2010;8(2):e1000315.
2007: Markus Rapedius; Jennifer J Paynter; Philip W Fowler; Lijun Shang; Mark S P Sansom; Stephen J Tucker; Thomas Baukrowitz
Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.
Channels (Austin, Tex.) 2007;1(5):327-30.
2007: Markus Rapedius; Philip W Fowler; Lijun Shang; Mark S P Sansom; Stephen J Tucker; Thomas Baukrowitz
H bonding at the helix-bundle crossing controls gating in Kir potassium channels.
Neuron 2007;55(4):602-14.
2006: Ekaterina Shumilina; Nikolaj Klöcker; Ganna Korniychuk; Markus Rapedius; Florian Lang; Thomas Baukrowitz
Cytoplasmic accumulation of long-chain coenzyme A esters activates KATP and inhibits Kir2.1 channels.
The Journal of physiology 2006;575(Pt 2):433-42.
2006: Markus Rapedius; haider shozeb; Katharine F Browne; Lijun Shang; Mark S P Sansom; Thomas Baukrowitz; Stephen J Tucker
Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.
EMBO reports 2006;7(6):611-6.
2005: Markus Rapedius; Malle Soom; Ekaterina Shumilina; Dirk Schulze; Roland Schönherr; Cornelia Kirsch; Florian Lang; Stephen J Tucker; Thomas Baukrowitz
Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.
The Journal of biological chemistry 2005;280(35):30760-7.
2004: Jason M Levine; Robert J Noecker; Lisa C Lane; Robert W Snyder; Markus Rapedius; James Blanchard
Aqueous penetration of gatifloxacin and levofloxacin into the rabbit aqueous humor following topical dosing.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2004;20(3):210-6.
2003: Dirk Schulze; Markus Rapedius; Tobias Krauter; Thomas Baukrowitz
Long-chain acyl-CoA esters and phosphatidylinositol phosphates modulate ATP inhibition of KATP channels by the same mechanism.
The Journal of physiology 2003;552(Pt 2):357-67.
2001: Markus Rapedius; James Blanchard
Comparison of the hanson microette and the Van Kel apparatus for in vitro release testing of topical semisolid formulations.
Pharmaceutical research 2001;18(10):1440-7.