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Ulf Rapp

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Verena Pfeiffer; Chaomei Xiang; Yina Zhang; Robert Blum; Attila Braun; Guadalupe Camarero; Rudolf Götz; Helmut Heinsen; Bernhard Nieswandt; Ulf R Rapp
Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum.
Fatih Ceteci; Semra Ceteci; Nefertiti El-Nikhely; Ludger Fink; Rajkumar Savai; Werner Seeger; Chitra Thakur; Emanuele Zanucco; Matthias Becker; Ulf R Rapp
E-cadherin controls bronchiolar progenitor cells and onset of preneoplastic lesions in mice.
Tripat Kaur Oberoi-Khanuja; Christiaan Karreman; Sarit Larisch; Ulf R Rapp; Krishnaraj Rajalingam
Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration.

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2013: Verena Pfeiffer; Chaomei Xiang; Yina Zhang; Robert Blum; Attila Braun; Guadalupe Camarero; Rudolf Götz; Helmut Heinsen; Bernhard Nieswandt; Ulf R Rapp
Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum.
PloS one 2013;8(3):e58259.
2012: Fatih Ceteci; Semra Ceteci; Nefertiti El-Nikhely; Ludger Fink; Rajkumar Savai; Werner Seeger; Chitra Thakur; Emanuele Zanucco; Matthias Becker; Ulf R Rapp
E-cadherin controls bronchiolar progenitor cells and onset of preneoplastic lesions in mice.
Neoplasia (New York, N.Y.) 2012;14(12):1164-77.
2012: Tripat Kaur Oberoi-Khanuja; Christiaan Karreman; Sarit Larisch; Ulf R Rapp; Krishnaraj Rajalingam
Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration.
The Journal of biological chemistry 2012;287(34):28445-55.
2012: Angela Baljuls; Matthias Beck; Mirko Hekman; Ruth Kroschewski; Ayla Oenel; Armin Robubi; Thomas Rudel; Ulf R Rapp
The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF.
The Journal of biological chemistry 2012;287(27):23128-40.
2012: Peggy Prickaerts; Ulf R Rapp; Frank Spaapen; Yoshihiro Takihara; Guus G H van den Akker; Michiel E Adriaens; Vivian E H Dahlmans; Claudia Geijselaers; Emmanuèle Mouchel-Vielh; Hanneke E C Niessen; Frédérique Peronnet; Jan Willem Voncken
MK3 controls Polycomb target gene expression via negative feedback on ERK.
Epigenetics & chromatin 2012;5(1):12.
2011: Fatih Ceteci; Semra Ceteci; Chitra Thakur; Jiajia Xu; Emanuele Zanucco; Ulf R Rapp
Conditional expression of oncogenic C-RAF in mouse pulmonary epithelial cells reveals differential tumorigenesis and induction of autophagy leading to tumor regression.
Neoplasia (New York, N.Y.) 2011;13(11):1005-18.
2011: Arnold R Sienerth; Antoine Galmiche; Ulf R Rapp; Christian Scheuermann; Matthias Becker
Polycomb group protein Bmi1 negatively regulates IL-10 expression in activated macrophages.
Immunology and cell biology 2011;89(7):812-6.
2011: Lisa Polzien; Angela Baljuls; Marco Albrecht; Mirko Hekman; Ulf R Rapp
BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling.
The Journal of biological chemistry 2011;286(20):17934-44.
2011: Angela Baljuls; Regina Mahr; Inge Schwarzenau; Thomas Müller; Lisa Polzien; Mirko Hekman; Ulf R Rapp
Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase.
The Journal of biological chemistry 2011;286(18):16491-503.
2011: Lisa Polzien; Angela Baljuls; Heide-Marie Roth; Jochen Kuper; Roland Benz; Kristian Schweimer; Mirko Hekman; Ulf R Rapp
Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part.
Biochimica et biophysica acta 2011;1810(2):162-9.
2011: Martin Heisig; Christian Hotz; Ulf R Rapp; Christoph Schoen; Jochen Stritzker; Birgit Bergmann; Joachim Fensterle; Alexa Frentzen; Katharina Galmbacher; Ivaylo Gentschev; Werner Goebel
Specific antibody-receptor interactions trigger InlAB-independent uptake of Listeria monocytogenes into tumor cell lines.
BMC microbiology 2011;11():163.
2010: Katharina Galmbacher; Martin Heisig; Christian Hotz; Joerg Wischhusen; Antoine Galmiche; Birgit Bergmann; Ivaylo Gentschev; Werner Goebel; Ulf R Rapp; Joachim Fensterle
Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression.
PloS one 2010;5(3):e9572.
2009: Lisa Polzien; Angela Baljuls; Ulrike E E Rennefahrt; Andreas Fischer; Werner Schmitz; René P Zahedi; Albert Sickmann; Renate Metz; Stefan Albert; Roland Benz; Mirko Hekman; Ulf R Rapp
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.
The Journal of biological chemistry 2009;284(41):28004-20.
2009: Christian Hotz; Joachim Fensterle; Werner Goebel; Susanne R Meyer; Gabriel Kirchgraber; Martin Heisig; Andreas Fürer; Guido Dietrich; Ulf R Rapp; Ivaylo Gentschev
Improvement of the live vaccine strain Salmonella enterica serovar Typhi Ty21a for antigen delivery via the hemolysin secretion system of Escherichia coli.
International journal of medical microbiology : IJMM 2009;299(2):109-19.
2009: Andreas Fischer; Angela Baljuls; Joerg Reinders; Elena Nekhoroshkova; Claudia Sibilski; Renate Metz; Stefan Albert; Krishnaraj Rajalingam; Mirko Hekman; Ulf R Rapp
Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins.
The Journal of biological chemistry 2009;284(5):3183-94.
2009: Elena Nekhoroshkova; Stefan Albert; Matthias Becker; Ulf R Rapp
A-RAF kinase functions in ARF6 regulated endocytic membrane traffic.
PloS one 2009;4(2):e4647.
2009: Matthias Becker; Christian Korn; Arnold R Sienerth; Robert Voswinckel; Katharina Luetkenhaus; Fatih Ceteci; Ulf R Rapp
Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer.
PloS one 2009;4(1):e4230.
2008: Taner Dogan; Gregory S Harms; Mirko Hekman; Christiaan Karreman; Tripat Kaur Oberoi; Emad S Alnemri; Ulf R Rapp; Krishnaraj Rajalingam
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
Nature cell biology 2008;10(12):1447-55.
2008: Angela Baljuls; Werner Schmitz; Thomas Mueller; René P Zahedi; Albert Sickmann; Mirko Hekman; Ulf R Rapp
Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites.
The Journal of biological chemistry 2008;283(40):27239-54.
2008: Roland Houben; Claudia S Vetter-Kauczok; Sonja Ortmann; Ulf R Rapp; Eva B Broecker; Jürgen C Becker
Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.
The Journal of investigative dermatology 2008;128(8):2003-12.
2008: Antoine Galmiche; Jochen Fueller; Ansgar Santel; Georg Krohne; Ilka Wittig; Anne Doye; Monica Rolando; Gilles Flatau; emmanuel lemichez; Ulf R Rapp
Isoform-specific interaction of C-RAF with mitochondria.
The Journal of biological chemistry 2008;283(21):14857-66.
2008: Joachim Fensterle; Birgit Bergmann; C L R P Yone; C Hotz; Susanne R Meyer; Simone Spreng; Werner Goebel; Ulf R Rapp; Ivaylo Gentschev
Cancer immunotherapy based on recombinant Salmonella enterica serovar Typhimurium aroA strains secreting prostate-specific antigen and cholera toxin subunit B.
Cancer gene therapy 2008;15(2):85-93.
2008: Ulf R Rapp; Fatih Ceteci; Ralf Schreck
Oncogene-induced plasticity and cancer stem cells.
Cell cycle (Georgetown, Tex.) 2008;7(1):45-51.
2008: Anatoly Samoylenko; Nadiya Byts; Krishnaraj Rajalingam; Nicolas Von Ahsen; Ulf R Rapp; Hannelore Ehrenreich; Anna-Leena Sirén
Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling.
Cellular signalling 2008;20(1):154-62.
2007: Sybille Mazurek; Hannes C A Drexler; Jakob Troppmair; Erich Eigenbrodt; Ulf R Rapp
Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism.
Anticancer research 2007;27(6B):3963-71.
2007: Andreas Latz; Dirk Becker; Mirko Hekman; T Müller; D Beyhl; Irene Marten; Christian Eing; Andreas Fischer; M Dunkel; Adam Bertl; Ulf R Rapp; Rainer Hedrich
TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins.
The Plant journal : for cell and molecular biology 2007;52(3):449-59.
2007: Andreas Fischer; Mirko Hekman; Jürgen Kuhlmann; Ignacio Rubio; Stefan Wiese; Ulf R Rapp
B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding.
The Journal of biological chemistry 2007;282(36):26503-16.
2007: Angela Baljuls; Thomas Mueller; Hannes C A Drexler; Mirko Hekman; Ulf R Rapp
Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates.
The Journal of biological chemistry 2007;282(36):26575-90.
2007: Fatih Ceteci; Semra Ceteci; Christiaan Karreman; Boris W Kramer; Esther Asan; Rudolf Götz; Ulf R Rapp
Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer.
Cancer cell 2007;12(2):145-59.
2007: Krishnaraj Rajalingam; Ralf Schreck; Ulf R Rapp; Stefan Albert
Ras oncogenes and their downstream targets.
Biochimica et biophysica acta 2007;1773(8):1177-95.
2007: Ivaylo Gentschev; Simone Spreng; Heike Sieber; Jose Ures; Fabian Mollet; Andre Collioud; Jon Pearman; Monika Griot-Wenk; Joachim Fensterle; Ulf R Rapp; Werner Goebel; Simon A Rothen; Guido Dietrich
Vivotif--a 'magic shield' for protection against typhoid fever and delivery of heterologous antigens.
Chemotherapy 2007;53(3):177-80.
2007: Ulf R Rapp; Andreas Fischer; Ulrike E E Rennefahrt; Mirko Hekman; Stefan Albert
BAD association with membranes is regulated by Raf kinases and association with 14-3-3 proteins.
Advances in enzyme regulation 2007;47():281-5.
2006: Ralf Schreck; Ulf R Rapp
Raf kinases: oncogenesis and drug discovery.
International journal of cancer. Journal international du cancer 2006;119(10):2261-71.
2006: Guadalupe Camarero; Oleg Yu Tyrsin; Chaomei Xiang; Verena Pfeiffer; Sandra Pleiser; Stefan Wiese; Rudolf Götz; Ulf R Rapp
Cortical migration defects in mice expressing A-RAF from the B-RAF locus.
Molecular and cellular biology 2006;26(19):7103-15.
2006: Mirko Hekman; Stefan Albert; Antoine Galmiche; Ulrike E E Rennefahrt; Jochen Fueller; Andreas Fischer; Dirk Puehringer; Stefan Wiese; Ulf R Rapp
Reversible membrane interaction of BAD requires two C-terminal lipid binding domains in conjunction with 14-3-3 protein binding.
The Journal of biological chemistry 2006;281(25):17321-36.
2006: Ulf R Rapp; Rudolf Götz; Stefan Albert
BuCy RAFs drive cells into MEK addiction.
Cancer cell 2006;9(1):9-12.
2005: Armin Robubi; Thomas Mueller; Jochen Fueller; Mirko Hekman; Ulf R Rapp; Thomas Dandekar
B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic kinase cascade.
Biological chemistry 2005;386(11):1165-71.
2005: Rudolf Götz; Stefan Wiese; Shinichi Takayama; Guadalupe Camarero; wilfried rossoll; Ulrich Schweizer; Jakob Troppmair; Sibylle Jablonka; Bettina Holtmann; John C Reed; Ulf R Rapp; Michael Sendtner
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.
Nature neuroscience 2005;8(9):1169-78.
2005: Krishnaraj Rajalingam; Christian Wunder; Volker Brinkmann; Yuri Churin; Mirko Hekman; Claudia Sievers; Ulf R Rapp; Thomas Rudel
Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.
Nature cell biology 2005;7(8):837-43.
2005: Jan Willem Voncken; Hanneke Niessen; Bernd Neufeld; Ulrike E E Rennefahrt; Vivian Dahlmans; Nard Kubben; Barbara Holzer; Stephan Ludwig; Ulf R Rapp
MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.
The Journal of biological chemistry 2005;280(7):5178-87.
2005: Ivaylo Gentschev; Joachim Fensterle; Andreas Schmidt; Tamara Potapenko; Jakob Troppmair; Werner Goebel; Ulf R Rapp
Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice.
BMC cancer 2005;5():15.
2005: Mirko Hekman; Andreas Fischer; Lawrence Wennogle; Y Karen Wang; Sharon L Campbell; Ulf R Rapp
Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation.
FEBS letters 2005;579(2):464-8.
2005: Roland Houben; Jürgen C Becker; Ulf R Rapp
Absence of mutations in the coding sequence of the potential tumor suppressor 3pK in metastatic melanoma.
Journal of carcinogenesis 2005;4():23.
2004: Rudolf Götz; Boris W Kramer; Guadalupe Camarero; Ulf R Rapp
BAG-1 haplo-insufficiency impairs lung tumorigenesis.
BMC cancer 2004;4():85.
2004: Ulrike E E Rennefahrt; Bertram Illert; Axel Greiner; Ulf R Rapp; Jakob Troppmair
Tumor induction by activated JNK occurs through deregulation of cellular growth.
Cancer letters 2004;215(1):113-24.
2004: Ivaylo Gentschev; Guido Dietrich; Simone Spreng; Beatrice Neuhaus; Elke Maier; Roland Benz; Werner Goebel; Joachim Fensterle; Ulf R Rapp
Use of the alpha-hemolysin secretion system of Escherichia coli for antigen delivery in the Salmonella typhi Ty21a vaccine strain.
International journal of medical microbiology : IJMM 2004;294(6):363-71.
2004: Joachim Fensterle; Jürgen C Becker; Tamara Potapenko; Veronika Heimbach; Claudia S Vetter; Eva-B Bröcker; Ulf R Rapp
B-Raf specific antibody responses in melanoma patients.
BMC cancer 2004;4():62.
2004: Veronika Olschläger; Stephan Pleschka; Timo Fischer; Hanns-Joachim Rziha; Walter J Wurzer; Lothar Stitz; Ulf R Rapp; Stephan Ludwig; Oliver Planz
Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice.
Oncogene 2004;23(39):6639-46.
2004: Mads Hald Andersen; Joachim Fensterle; Selma Ugurel; Sine Reker Hadrup; Roland Houben; Per Guldberg; Thomas G Berger; Dirk Schadendorf; Uwe Trefzer; Eva-B Bröcker; Ulf R Rapp; Per thor Straten; Jürgen C Becker
Immunogenicity of constitutively active V599EBRaf.
Cancer research 2004;64(15):5456-60.
2004: Boris W Kramer; Rudolf Götz; Ulf R Rapp
Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure.
BMC cancer 2004;4():24.
2004: Mirko Hekman; Stefan Wiese; Renate Metz; Stefan Albert; Jakob Troppmair; Joachim Nickel; Michael Sendtner; Ulf R Rapp
Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites.
The Journal of biological chemistry 2004;279(14):14074-86.
2004: Ulf R Rapp; Ulrike E E Rennefahrt; Jakob Troppmair
Bcl-2 proteins: master switches at the intersection of death signaling and the survival control by Raf kinases.
Biochimica et biophysica acta 2004;1644(2-3):149-58.
2003: Thomas Raabe; Ulf R Rapp
Ras signaling: PP2A puts Ksr and Raf in the right place.
Current biology : CB 2003;13(16):R635-7.
2003: Lev Fedorov; Thomas Papadopoulos; Oleg Yu Tyrsin; Thomas Twardzik; Rudolf Götz; Ulf R Rapp
Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch.
Cancer research 2003;63(9):2268-77.
2003: Ulf R Rapp; Joachim Fensterle; Stefan Albert; Rudolf Götz
Raf kinases in lung tumor development.
Advances in enzyme regulation 2003;43():183-95.
2002: Lev Fedorov; Oleg Yu Tyrsin; Thomas Papadopoulos; Guadalupe Camarero; Rudolf Götz; Ulf R Rapp
Bcl-2 determines susceptibility to induction of lung cancer by oncogenic CRaf.
Cancer research 2002;62(21):6297-303.
2002: Ulrike E E Rennefahrt; Bertram Illert; Eugen Kerkhoff; Jakob Troppmair; Ulf R Rapp
Constitutive JNK activation in NIH 3T3 fibroblasts induces a partially transformed phenotype.
The Journal of biological chemistry 2002;277(33):29510-8.
2002: Manfred Kunz; Gisela Bloss; Reinhard Gillitzer; Gerd Gross; Matthias Goebeler; Ulf R Rapp; Stephan Ludwig
Hypoxia/reoxygenation induction of monocyte chemoattractant protein-1 in melanoma cells: involvement of nuclear factor-kappaB, stimulatory protein-1 transcription factors and mitogen-activated protein kinase pathways.
The Biochemical journal 2002;366(Pt 1):299-306.
2002: Mirko Hekman; Heike Hamm; Ana V Villar; Benjamin Bader; Jurgen Kuhlmann; Joachim Nickel; Ulf R Rapp
Associations of B- and C-Raf with cholesterol, phosphatidylserine, and lipid second messengers: preferential binding of Raf to artificial lipid rafts.
The Journal of biological chemistry 2002;277(27):24090-102.
2002: Véronique Le Mellay; Jakob Troppmair; Roland Benz; Ulf R Rapp
Negative regulation of mitochondrial VDAC channels by C-Raf kinase.
BMC cell biology 2002;3():14.
2002: Eugen Kerkhoff; Cornelia B Leberfinger; Gudula Schmidt; Klaus Aktories; Ulf R Rapp
Diverse effects of RacV12 on cell transformation by Raf: partial inhibition of morphological transformation versus deregulation of cell cycle control.
Biochimica et biophysica acta 2002;1589(2):151-9.
2002: Silja Wessler; Ulf R Rapp; Bertram Wiedenmann; Thomas F Meyer; Torsten Schöneberg; Michael Höcker; Michael Naumann
B-Raf/Rap1 signaling, but not c-Raf-1/Ras, induces the histidine decarboxylase promoter in Helicobacter pylori infection.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(3):417-9.
2002: Véronique Le Mellay; Roland Houben; Jakob Troppmair; Carsten Hagemann; Sybille Mazurek; Ulrich Frey; Jürgen Beigel; Christoph Weber; Roland Benz; Erich Eigenbrodt; Ulf R Rapp
Regulation of glycolysis by Raf protein serine/threonine kinases.
Advances in enzyme regulation 2002;42():317-32.
2001: Eugen Kerkhoff; J C Simpson; Cornelia B Leberfinger; I M Otto; T Doerks; Peer Bork; Ulf R Rapp; Thomas Raabe; R Pepperkok
The Spir actin organizers are involved in vesicle transport processes.
Current biology : CB 2001;11(24):1963-8.
2001: BW Jordan; D Dinev; V LeMellay; Jakob Troppmair; R Gotz; L Wixler; Michael Sendtner; Stephan Ludwig; Ulf R Rapp
Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death.
The Journal of biological chemistry 2001;276(43):39985-9.
2001: D Dinev; BW Jordan; B Neufeld; J D Lee; D Lindemann; Ulf R Rapp; Stephan Ludwig
Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells.
EMBO reports 2001;2(9):829-34.
2001: J Zhong; Jakob Troppmair; Ulf R Rapp
Independent control of cell survival by Raf-1 and Bcl-2 at the mitochondria.
Oncogene 2001;20(35):4807-16.
2001: Stephan Ludwig; Christina Ehrhardt; E R Neumeier; M Kracht; Ulf R Rapp; Stephan Pleschka
Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway.
The Journal of biological chemistry 2001;276(24):10990-8.
2001: Lev Fedorov; Oleg Yu Tyrsin; V Krenn; Elena V Chernigovskaya; Ulf R Rapp
Tet-system for the regulation of gene expression during embryonic development.
Transgenic research 2001;10(3):247-58.
2001: Christoph K Weber; Joseph Slupsky; H A Kalmes; Ulf R Rapp
Active Ras induces heterodimerization of cRaf and BRaf.
Cancer research 2001;61(9):3595-8.
2001: Stephan Ludwig; Christina Ehrhardt; E R Neumeier; M Kracht; Ulf R Rapp; Stephan Pleschka
Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway.
The Journal of biological chemistry 2001;276(14):10990-8.
2001: A von Gise; P Lorenz; Claudia Wellbrock; B Hemmings; Friederike Berberich-Siebelt; Ulf R Rapp; Jakob Troppmair
Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals.
Molecular and cellular biology 2001;21(7):2324-36.
2001: Manfred Kunz; S Ibrahim; D Koczan; H J Thiesen; H J Köhler; Till Acker; K H Plate; Stephan Ludwig; Ulf R Rapp; E B Bröcker; G N van Muijen; Egbert Flory; G Gross
Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(3):137-45.
2001: Stephan Pleschka; Thorsten Wolff; Christina Ehrhardt; Gerd Hobom; Oliver Planz; Ulf R Rapp; Stephan Ludwig
Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade.
Nature cell biology 2001;3(3):301-5.
2001: Stefan Wiese; G Pei; Christoph Karch; Jakob Troppmair; Bettina Holtmann; Ulf R Rapp; Michael Sendtner
Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons.
Nature neuroscience 2001;4(2):137-42.
2001: Eugen Kerkhoff; Ulf R Rapp
The Ras-Raf relationship: an unfinished puzzle.
Advances in enzyme regulation 2001;41():261-7.
2001: Matthias Goebeler; R Gillitzer; K Kilian; K Utzel; Eva-B Bröcker; Ulf R Rapp; Stephan Ludwig
Multiple signaling pathways regulate NF-kappaB-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells.
Blood 2001;97(1):46-55.
2000: M Schmidt; Matthias Goebeler; Guido Posern; Stephan M Feller; C S Seitz; Eva-Bettina Brocker; Ulf R Rapp; Stephan Ludwig
Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes.
The Journal of biological chemistry 2000;275(52):41011-7.
2000: Guido Posern; Ulf R Rapp; Stephan M Feller
The Crk signaling pathway contributes to the bombesin-induced activation of the small GTPase Rap1 in Swiss 3T3 cells.
Oncogene 2000;19(54):6361-8.
2000: Rudolf Götz; Christoph Karch; M R Digby; Jakob Troppmair; Ulf R Rapp; Michael Sendtner
The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells.
Human molecular genetics 2000;9(17):2479-89.
2000: B Neufeld; A Grosse-Wilde; A Hoffmeyer; BW Jordan; P Chen; D Dinev; Stephan Ludwig; Ulf R Rapp
Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity.
The Journal of biological chemistry 2000;275(27):20239-42.
2000: P Chen; Egbert Flory; Andris Avots; BW Jordan; F Kirchhoff; Stephan Ludwig; Ulf R Rapp
Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors.
The Journal of biological chemistry 2000;275(27):20382-90.
2000: Bernd Baumann; Christoph K Weber; Jakob Troppmair; ST Whiteside; Alain Israel; Ulf R Rapp; Thomas Wirth
Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4615-20.
2000: Eugen Kerkhoff; Lev Fedorov; R Siefken; A O Walter; Thomas Papadopoulos; Ulf R Rapp
Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(4):185-90.
2000: Egbert Flory; Manfred Kunz; Carsten Scheller; Christian Jassoy; R Stauber; Ulf R Rapp; Stephan Ludwig
Influenza virus-induced NF-kappaB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB kinase.
The Journal of biological chemistry 2000;275(12):8307-14.
2000: I M Otto; Thomas Raabe; Ulrike E E Rennefahrt; Peer Bork; Ulf R Rapp; Eugen Kerkhoff
The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization.
Current biology : CB 2000;10(6):345-8.
2000: Christoph K Weber; Joseph Slupsky; Christian Herrmann; M Schuler; Ulf R Rapp; C Block
Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes.
Oncogene 2000;19(2):169-76.
1999: Carsten Hagemann; Ulf R Rapp
Isotype-specific functions of Raf kinases.
Experimental cell research 1999;253(1):34-46.
1999: Joseph Slupsky; Ursula Quitterer; Christoph K Weber; P Gierschik; Martin J Lohse; Ulf R Rapp
Binding of Gbetagamma subunits to cRaf1 downregulates G-protein-coupled receptor signalling.
Current biology : CB 1999;9(17):971-4.
1999: Andris Avots; Mathias Buttmann; Sergei Chuvpilo; C Escher; U Smola; A J Bannister; Ulf R Rapp; T Kouzarides; Edgar Serfling
CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation.
Immunity 1999;10(5):515-24.
1999: Jörg Hartkamp; Jakob Troppmair; Ulf R Rapp
The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion.
Cancer research 1999;59(9):2195-202.
1999: D Hagemann; Jakob Troppmair; Ulf R Rapp
Cot protooncoprotein activates the dual specificity kinases MEK-1 and SEK-1 and induces differentiation of PC12 cells.
Oncogene 1999;18(7):1391-400.
1999: A Hoffmeyer; A Grosse-Wilde; Egbert Flory; B Neufeld; Manfred Kunz; Ulf R Rapp; Stephan Ludwig
Different mitogen-activated protein kinase signaling pathways cooperate to regulate tumor necrosis factor alpha gene expression in T lymphocytes.
The Journal of biological chemistry 1999;274(7):4319-27.
1999: Matthias Goebeler; K Kilian; R Gillitzer; M Kunz; T Yoshimura; Eva-B Bröcker; Ulf R Rapp; Stephan Ludwig
The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells.
Blood 1999;93(3):857-65.
1998: M Daub; J Jöckel; T Quack; Christoph K Weber; F Schmitz; Ulf R Rapp; Alfred Wittinghofer; C Block
The RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activation.
Molecular and cellular biology 1998;18(11):6698-710.
1998: Guido Posern; Christoph K Weber; Ulf R Rapp; Stephan M Feller
Activity of Rap1 is regulated by bombesin, cell adhesion, and cell density in NIH3T3 fibroblasts.
The Journal of biological chemistry 1998;273(38):24297-300.
1998: Eugen Kerkhoff; Ulf R Rapp
Cell cycle targets of Ras/Raf signalling.
Oncogene 1998;17(11 Reviews):1457-62.
1998: Jakob Troppmair; Jörg Hartkamp; Ulf R Rapp
Activation of NF-kappa B by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade.
Oncogene 1998;17(6):685-90.
1998: V Afanassiev; Jakob Troppmair; M Schuler; C Weber; Ulf R Rapp
Production and characterization of monoclonal antibodies against human BAD protein.
Hybridoma 1998;17(4):383-7.
1998: A Kalmes; Carsten Hagemann; Christoph K Weber; L Wixler; T Schuster; Ulf R Rapp
Interaction between the protein kinase B-Raf and the alpha-subunit of the 11S proteasome regulator.
Cancer research 1998;58(14):2986-90.
1998: A Hoffmeyer; Andris Avots; Egbert Flory; Christoph K Weber; Edgar Serfling; Ulf R Rapp
The GABP-responsive element of the interleukin-2 enhancer is regulated by JNK/SAPK-activating pathways in T lymphocytes.
The Journal of biological chemistry 1998;273(17):10112-9.
1998: Eugen Kerkhoff; Ulf R Rapp
High-intensity Raf signals convert mitotic cell cycling into cellular growth.
Cancer research 1998;58(8):1636-40.
1998: Egbert Flory; Christoph K Weber; P Chen; A Hoffmeyer; Christian Jassoy; Ulf R Rapp
Plasma membrane-targeted Raf kinase activates NF-kappaB and human immunodeficiency virus type 1 replication in T lymphocytes.
Journal of virology 1998;72(4):2788-94.
1998: Stephan Ludwig; A Hoffmeyer; Matthias Goebeler; K Kilian; H Häfner; B Neufeld; J Han; Ulf R Rapp
The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway.
The Journal of biological chemistry 1998;273(4):1917-22.
1998: Eugen Kerkhoff; Roland Houben; S Löffler; Jakob Troppmair; J E Lee; Ulf R Rapp
Regulation of c-myc expression by Ras/Raf signalling.
Oncogene 1998;16(2):211-6.
1997: Andris Avots; A Hoffmeyer; Egbert Flory; A Cimanis; Ulf R Rapp; Edgar Serfling
GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction.
Molecular and cellular biology 1997;17(8):4381-9.
1997: Eugen Kerkhoff; Ulf R Rapp
Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1.
Molecular and cellular biology 1997;17(5):2576-86.
1997: I Weiglein; Werner Goebel; Jakob Troppmair; Ulf R Rapp; A Demuth; Michael Kuhn
Listeria monocytogenes infection of HeLa cells results in listeriolysin O-mediated transient activation of the Raf-MEK-MAP kinase pathway.
FEMS microbiology letters 1997;148(2):189-95.
1997: Carsten Hagemann; A Kalmes; V Wixler; L Wixler; T Schuster; Ulf R Rapp
The regulatory subunit of protein kinase CK2 is a specific A-Raf activator.
FEBS letters 1997;403(2):200-2.
1997: Roland Houben; Jakob Troppmair; J Hidalgo; Ulf R Rapp
Differential gene expression in apoptotic 32Dcl3 cells: induction of metallothionein.
Apoptosis : an international journal on programmed cell death 1997;2(1):40-6.
1997: Jakob Troppmair; Ulf R Rapp
Apoptosis regulation by Raf, Bcl-2, and R-Ras.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1997;143():245-9.
1997: U Naumann; I Eisenmann-Tappe; Ulf R Rapp
The role of Raf kinases in development and growth of tumors.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1997;143():237-44.
1996: Stephan Ludwig; K Engel; A Hoffmeyer; G Sithanandam; B Neufeld; D Palm; M Gaestel; Ulf R Rapp
3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways.
Molecular and cellular biology 1996;16(12):6687-97.
1996: V Wixler; U Smola; M Schuler; Ulf R Rapp
Differential regulation of Raf isozymes by growth versus differentiation inducing factors in PC12 pheochromocytoma cells.
FEBS letters 1996;385(3):131-7.
1996: Egbert Flory; A Hoffmeyer; U Smola; Ulf R Rapp; J T Bruder
Raf-1 kinase targets GA-binding protein in transcriptional regulation of the human immunodeficiency virus type 1 promoter.
Journal of virology 1996;70(4):2260-8.
1994: G Daum; I Eisenmann-Tappe; H W Fries; Jakob Troppmair; Ulf R Rapp
The ins and outs of Raf kinases.
Trends in biochemical sciences 1994;19(11):474-80.