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Rino Rappuoli

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Diana Boraschi; M Teresa Aguado; Catherine Dutel; Jörg Goronzy; Beatrix Grubeck-Loebenstein; Jacques Louis; Rino Rappuoli; Giuseppe Del Giudice
The gracefully aging immune system.
Robert C Brunham; Rino Rappuoli
Chlamydia trachomatis control requires a vaccine.
Enrico Malito; giulietta maruggi; Isabella Bertoldi; Erica Borgogni; Matthew J Bottomley; Sébastien Brier; Elena Cartocci; Flora Castellino; Maria Domina; Agnese Faleri; Franco Felici; Alessia Genovese; Eva Grassi; Steven Johnson; Susan M Lea; Carla Lo Passo; Paola Lo Surdo; Nathalie Norais; Mariagrazia Pizza; Rino Rappuoli; Giacomo Romagnoli; Laura Santini; Silvana Savino; Christoph M Tang; Stijn van der Veen; Daniele Veggi; Vega Masignani
Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen.

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2013: Diana Boraschi; M Teresa Aguado; Catherine Dutel; Jörg Goronzy; Beatrix Grubeck-Loebenstein; Jacques Louis; Rino Rappuoli; Giuseppe Del Giudice
The gracefully aging immune system.
Science translational medicine 2013;5(185):185ps8.
2013: Robert C Brunham; Rino Rappuoli
Chlamydia trachomatis control requires a vaccine.
Vaccine 2013;31(15):1892-7.
2013: Enrico Malito; giulietta maruggi; Isabella Bertoldi; Erica Borgogni; Matthew J Bottomley; Sébastien Brier; Elena Cartocci; Flora Castellino; Maria Domina; Agnese Faleri; Franco Felici; Alessia Genovese; Eva Grassi; Steven Johnson; Susan M Lea; Carla Lo Passo; Paola Lo Surdo; Nathalie Norais; Mariagrazia Pizza; Rino Rappuoli; Giacomo Romagnoli; Laura Santini; Silvana Savino; Christoph M Tang; Stijn van der Veen; Daniele Veggi; Vega Masignani
Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(9):3304-9.
2013: Isabel Delany; Rino Rappuoli; Kate L Seib
Vaccines, reverse vaccinology, and bacterial pathogenesis.
Cold Spring Harbor perspectives in medicine 2013;3(5):.
2013: Derek T O'Hagan; Gary S Ott; Rino Rappuoli; Gary Van Nest; Giuseppe Del Giudice
The history of MF59(®) adjuvant: a phoenix that arose from the ashes.
Expert review of vaccines 2013;12(1):13-30.
2013: Giuseppe Del Giudice; Giovanni Della Cioppa; Elena Fragapane; Rino Rappuoli
Aflunov®: a vaccine tailored for pre-pandemic and pandemic approaches against influenza.
Expert opinion on biological therapy 2013;13(1):121-35.
2012: Philip R Dormitzer; Guido Grandi; Rino Rappuoli
Structural vaccinology starts to deliver.
Nature reviews. Microbiology 2012;10(12):807-13.
2012: Daniele Veggi; Kate L Seib; Lucia Banci; Francesca Cantini; Maria A Gentile; Paola Lo Surdo; Vincenzo Nardi-Dei; Mariagrazia Pizza; Rino Rappuoli; Silvana Savino; Maria Scarselli
The factor H binding protein of Neisseria meningitidis interacts with xenosiderophores in vitro.
Biochemistry 2012;51(46):9384-93.
2012: Ravi P N Mishra; Ernesto Oviedo-Orta; Prachi Prachi; Rino Rappuoli; Fabio Bagnoli
Vaccines and antibiotic resistance.
Current opinion in microbiology 2012;15(5):596-602.
2012: K L Seib; X Zhao; Rino Rappuoli
Developing vaccines in the era of genomics: a decade of reverse vaccinology.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2012;18 Suppl 5():109-16.
2012: Andrew J Geall; Armin Hekele; Thomas Krucker; Kaustuv Banerjee; Susan W Barnett; Clayton W Beard; Luis A Brito; Yen Cu; Philip R Dormitzer; Peter W Mason; Derek T O'Hagan; Gillis R Otten; Rino Rappuoli; Christine A Shaw; Manmohan Singh; Jeffrey B Ulmer; Nicholas M Valiante; Ayush Verma; Christian W Mandl
Nonviral delivery of self-amplifying RNA vaccines.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14604-9.
2012: Ronza Hadad; Susanne Jacobsson; Per OlcEn; Mariagrazia Pizza; Rino Rappuoli; Hans Fredlund; Magnus Unemo
Novel meningococcal 4CMenB vaccine antigens - prevalence and polymorphisms of the encoding genes in Neisseria gonorrhoeae.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2012;120(9):750-60.
2012: Sébastien Brier; Isabel Delany; Danilo Donnarumma; Luca Fagnocchi; Mikkel Nissum; Rino Rappuoli; Maria Scarselli; Nathalie Norais
Structural insight into the mechanism of DNA-binding attenuation of the Neisserial adhesin repressor NadR by the small natural ligand 4-hydroxyphenylacetic acid.
Biochemistry 2012;51(34):6738-52.
2012: Suryaprakash Sambhara; Rino Rappuoli
Improving influenza vaccines.
Expert review of vaccines 2012;11(8):871-2.
2012: Ernesto Oviedo-Orta; S Sohail Ahmed; Rino Rappuoli
Human papillomavirus E2 protein: a potential key regulator of viral cell pathogenesis.
Pathogens and global health 2012;106(3):141.
2012: Yasushi Uematsu; Michael Vajdy; Rino Rappuoli; Giulietta Saletti; Susan W Barnett; Grazia Galli; Catherine E Greer; Harold Legg; Ying Lian; Gillis R Otten; Silvia Perri; John M Polo
Lack of interference with immunogenicity of a chimeric alphavirus replicon particle-based influenza vaccine by preexisting antivector immunity.
Clinical and vaccine immunology : CVI 2012;19(7):991-8.
2012: Rino Rappuoli; Philip R Dormitzer
Influenza: options to improve pandemic preparation.
Science (New York, N.Y.) 2012;336(6088):1531-3.
2012: Elisa Faenzi; Oretta Finco; Syed Sohail Ahmed; Monia Bardelli; Riccardo Belli; Erica Borgogni; Francesca Buricchi; Pier Leopoldo Capecchi; Flora Castellino; Giuseppe Del Giudice; Maria Lattanzi; Fabio Montanaro; EMANUELE MONTOMOLI; Franco Laghi Pasini; Simona Piccirella; Rino Rappuoli; Fabiana Spensieri; Gianfranco Volpini; Luisanna Zedda; Grazia Galli
One dose of an MF59-adjuvanted pandemic A/H1N1 vaccine recruits pre-existing immune memory and induces the rapid rise of neutralizing antibodies.
Vaccine 2012;30(27):4086-94.
2012: Meera Unnikrishnan; Rino Rappuoli; Davide Serruto
Recombinant bacterial vaccines.
Current opinion in immunology 2012;24(3):337-42.
2012: Davide Serruto; Matthew J Bottomley; Marzia M Giuliani; Sanjay Ram; Rino Rappuoli
The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens.
Vaccine 2012;30 Suppl 2():B87-97.
2012: Rino Rappuoli; Mariagrazia Pizza; Steven Black; E Richard Moxon
Development of a vaccine against serogroup B has been the main scientific challenge. Preface.
Vaccine 2012;30 Suppl 2():B1-2.
2012: Rino Rappuoli; Donata Medaglini
ADITEC: joining forces for next-generation vaccines.
Science translational medicine 2012;4(128):128cm4.
2012: Enrico Malito; Mikkel Nissum; Monica Picchianti; Rino Rappuoli; Paola Lo Surdo; Enrico Balducci; Francesco Berti; Marco Biancucci; Matthew James Bottomley; Ansgar Brock; Badry Bursulaya; Connie Chen; Paolo Costantino; Glen Spraggon
Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):5229-34.
2012: Paolo Montanari; Nathalie Norais; Mariagrazia Pizza; Rino Rappuoli; Michele Sallese; Beatrice Aricò; Riccardo Barrile; Giuseppe Bozza; Barbara Capecchi; Mirco Capitani; Elena Caproni; Paola Cecchini; Laura Ciucchi; Zhenai Gao; Marcello Merola
Human heat shock protein (Hsp) 90 interferes with Neisseria meningitidis adhesin A (NadA)-mediated adhesion and invasion.
Cellular microbiology 2012;14(3):368-85.
2012: Ennio De Gregorio; Rino Rappuoli
Vaccines for the future: learning from human immunology.
Microbial biotechnology 2012;5(2):149-55.
2012: Steven Black; Mikkel Nissum; Mariagrazia Pizza; Rino Rappuoli
Toward a meningitis-free world.
Science translational medicine 2012;4(123):123ps5.
2012: Danilo G Moriel; Mariagrazia Pizza; Roberto Rosini; Kate L Seib; Laura Serino; Rino Rappuoli
Escherichia coli: great diversity around a common core.
mBio 2012;3(3):.
2012: Barbara Nesta; Ilaria Pastorello; Mariagrazia Pizza; Rino Rappuoli; Roberto Rosini; Laura Serino; Sara Smith; Christopher Alteri; Isabella Bertoldi; Ilaria Ferlenghi; Maria Rita Fontana; Gad Frankel; harry mobley; Glen Spraggon; Daniele Veggi; Danilo Gomes Moriel; Marco Soriani
FdeC, a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections.
mBio 2012;3(2):.
2011: Rino Rappuoli; Ennio De Gregorio
A sweet T cell response.
Nature medicine 2011;17(12):1551-2.
2011: Rino Rappuoli; Christian W Mandl; Steven Black; Ennio De Gregorio
Vaccines for the twenty-first century society.
Nature reviews. Immunology 2011;11(12):865-72.
2011: Steven Black; Ralf Clemens; Giuseppe Del Giudice; Giovanni Della Cioppa; Markus Knuf; Uwe Nicolay; Theodore Tsai; Timo Vesikari; Rino Rappuoli
Hemagglutination inhibition antibody titers as a correlate of protection for inactivated influenza vaccines in children.
The Pediatric infectious disease journal 2011;30(12):1081-5.
2011: Rino Rappuoli
Twenty-first century vaccines.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1579):2756-8.
2011: Paolo Costantino; Rino Rappuoli; Francesco Berti
The design of semi-synthetic and synthetic glycoconjugate vaccines.
Expert opinion on drug discovery 2011;6(10):1045-66.
2011: Kate L Seib; Isabel Delany; Jayde A Gawthorne; Michael P Jennings; Alessandro Muzzi; Eva Pigozzi; Rino Rappuoli
A novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(10):3622-33.
2011: Alan Bernstein; Bali Pulendran; Rino Rappuoli
Systems vaccinomics: the road ahead for vaccinology.
Omics : a journal of integrative biology 2011;15(9):529-31.
2011: Fabio Bagnoli; Erika Bartolini; Barbara Baudner; Phil Boucher; Luigi Fiaschi; Paolo Mariotti; Ravi P N Mishra; Vincenzo Nardi-Dei; Rino Rappuoli
Designing the next generation of vaccines for global public health.
Omics : a journal of integrative biology 2011;15(9):545-66.
2011: Rino Rappuoli; Steven Black; Paul Henri Lambert
Vaccine discovery and translation of new vaccine technology.
Lancet 2011;378(9788):360-8.
2011: Maria Scarselli; Marta Tontini; Daniele Veggi; Silvana Savino; Beatrice Aricò; Lucia Banci; Matthew James Bottomley; Barbara Brogioni; Brunella Brunelli; Francesca Cantini; Elena Cartocci; Laura Ciucchi; Annalisa Colaprico; Maurizio Comanducci; Federica Di Marcello; Francesco Doro; Sara Dragonetti; Patrizia Giannetti; Marzia Monica Giuliani; Markus Hilleringmann; Paola Lo Surdo; Enrico Malito; Vincenzo Nardi-Dei; Michele Pallaoro; Emmanuelle Palumbo; Mariagrazia Pizza; Rino Rappuoli
Rational design of a meningococcal antigen inducing broad protective immunity.
Science translational medicine 2011;3(91):91ra62.
2011: Anja Seubert; Sara Valentini; Andreas Wack; Susanna Aprea; Samuele Calabro'; Annalisa Colaprico; Ugo D'Oro; Barbara Galli; Alessia Genovese; Marzia M Giuliani; Derek T O'Hagan; Michele Pallaoro; Mariagrazia Pizza; Rino Rappuoli; Laura Santini; Ennio De Gregorio
Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(27):11169-74.
2011: Michael Bröker; Paolo Costantino; Lisa DeTora; E David McIntosh; Rino Rappuoli
Biochemical and biological characteristics of cross-reacting material 197 CRM197, a non-toxic mutant of diphtheria toxin: use as a conjugation protein in vaccines and other potential clinical applications.
Biologicals : journal of the International Association of Biological Standardization 2011;39(4):195-204.
2011: Xin Wang; Xin Zhao; Nancy E Messonnier; Ellen Murphy; Alessandro Muzzi; Mariagrazia Pizza; Rino Rappuoli; Susanna Schmink; Annaliesa S Anderson; Lubomira Andrew; Stefania Bambini; Thomas A Clark; Amanda C Cohn; Maurizio Comanducci; Lee H Harrison; Susan K Hoiseth; Kathrin U Jansen; Jessica R MacNeil; Leonard W Mayer
Prevalence and genetic diversity of candidate vaccine antigens among invasive Neisseria meningitidis isolates in the United States.
Vaccine 2011;29(29-30):4739-44.
2011: Annalisa Nuccitelli; Rino Rappuoli; John L Telford; Martino Bolognesi; Roberta Cozzi; Danilo Donnarumma; Louise J Gourlay; Guido Grandi; Domenico Maione; Francesca Necchi; Nathalie Norais; Cira Daniela Rinaudo
Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(25):10278-83.
2011: Kurt A Swanson; Antu K Dey; Philip R Dormitzer; Christian W Mandl; Rino Rappuoli; Ethan C Settembre; Christine A Shaw; Andrea Carfi
Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(23):9619-24.
2011: Surender Khurana; Nitin Verma; Jonathan W Yewdell; Anne Katrin Hilbert; Flora Castellino; Maria Lattanzi; Giuseppe Del Giudice; Rino Rappuoli; Hana Golding
MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines.
Science translational medicine 2011;3(85):85ra48.
2011: Ethan C Settembre; Philip R Dormitzer; Rino Rappuoli
Learning from the 2009 H1N1 pandemic: prospects for more broadly effective influenza vaccines.
Journal of molecular cell biology 2011;3(3):144-6.
2011: Ludovico Buti; Eric Spooner; Annemarthe G Van der Veen; Rino Rappuoli; Antonello Covacci; Hidde L Ploegh
Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(22):9238-43.
2011: Rino Rappuoli; Alan Aderem
A 2020 vision for vaccines against HIV, tuberculosis and malaria.
Nature 2011;473(7348):463-9.
2011: Corinna F Brereton; Caroline E Sutton; Pádraig J Ross; Yoichiro Iwakura; Mariagrazia Pizza; Rino Rappuoli; E C Lavelle; Kingston H G Mills
Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):5896-906.
2011: Hebert Echenique-Rivera; Alessandro Muzzi; Elena Del Tordello; Kate L Seib; Patrice Francois; Rino Rappuoli; Mariagrazia Pizza; Davide Serruto
Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival.
PLoS pathogens 2011;7(5):e1002027.
2011: Derek T O'Hagan; Rino Rappuoli; Ennio De Gregorio; Theodore Tsai; Giuseppe Del Giudice
MF59 adjuvant: the best insurance against influenza strain diversity.
Expert review of vaccines 2011;10(4):447-62.
2011: Sonia Budroni; Emilio Siena; Kate L Seib; Davide Serruto; Chiara Nofroni; Maurizio Comanducci; David R Riley; Sean C Daugherty; Samuel V Angiuoli; Antonello Covacci; Mariagrazia Pizza; Rino Rappuoli; E Richard Moxon; Hervé Tettelin; Julie C Hotopp; Duccio Medini
Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(11):4494-9.
2011: Judith van den Brand; Joost H C M Kreijtz; Rogier Bodewes; Koert J Stittelaar; Geert van Amerongen; Thijs Kuiken; James Simon; Ron A M Fouchier; Giuseppe Del Giudice; Rino Rappuoli; Guus F Rimmelzwaan; Albert D M E Osterhaus
Efficacy of vaccination with different combinations of MF59-adjuvanted and nonadjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza virus infection in ferrets.
Journal of virology 2011;85(6):2851-8.
2011: Kate L Seib; Brunella Brunelli; Barbara Brogioni; Emmanuelle Palumbo; Stefania Bambini; Alessandro Muzzi; Federica DiMarcello; Sara Marchi; Arie van der Ende; Beatrice Aricó; Silvana Savino; Maria Scarselli; Maurizio Comanducci; Rino Rappuoli; Marzia M Giuliani; Mariagrazia Pizza
Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies.
Infection and immunity 2011;79(2):970-81.
2011: Brunella Brunelli; Elena Del Tordello; Emmanuelle Palumbo; Alessia Biolchi; Stefania Bambini; Maurizio Comanducci; Alessandro Muzzi; Mariagrazia Pizza; Rino Rappuoli; John J Donnelly; Marzia M Giuliani; Davide Serruto
Influence of sequence variability on bactericidal activity sera induced by Factor H binding protein variant 1.1.
Vaccine 2011;29(5):1072-81.
2011: Rino Rappuoli
The challenge of developing universal vaccines.
F1000 medicine reports 2011;3():16.
2011: Philip R Dormitzer; Grazia Galli; Flora Castellino; Hana Golding; Surender Khurana; Giuseppe Del Giudice; Rino Rappuoli
Influenza vaccine immunology.
Immunological reviews 2011;239(1):167-77.
2010: Anna Kabanova; Immaculada Margarit; Francesco Berti; Maria R Romano; Guido Grandi; Giuliano Bensi; Emiliano Chiarot; Daniela Proietti; Erwin Frans M. Swennen; Emilia Cappelletti; Paola Fontani; Daniele Casini; Roberto Adamo; Vittoria Pinto; David Skibinski; Sabrina Capo; Giada Buffi; Marilena Gallotta; William J Christ; A Stewart Campbell; John Pena; Peter H Seeberger; Rino Rappuoli; Paolo Costantino
Evaluation of a Group A Streptococcus synthetic oligosaccharide as vaccine candidate.
Vaccine 2010;29(1):104-14.
2010: Steven Black; Rino Rappuoli
A crisis of public confidence in vaccines.
Science translational medicine 2010;2(61):61mr1.
2010: John Donnelly; Duccio Medini; Giuseppe Boccadifuoco; Alessia Biolchi; Joel Ward; Carl Frasch; E Richard Moxon; Maria Stella; Maurizio Comanducci; Stefania Bambini; Alessandro Muzzi; William Andrews; Jie Chen; George Santos; Laura Santini; Philip Boucher; Davide Serruto; Mariagrazia Pizza; Rino Rappuoli; Marzia M Giuliani
Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(45):19490-5.
2010: Alessandro Sette; Rino Rappuoli
Reverse vaccinology: developing vaccines in the era of genomics.
Immunity 2010;33(4):530-41.
2010: Marzia M Giuliani; Alessia Biolchi; Davide Serruto; Francesca Ferlicca; Kay Vienken; Philipp Oster; Rino Rappuoli; Mariagrazia Pizza; John Donnelly
Measuring antigen-specific bactericidal responses to a multicomponent vaccine against serogroup B meningococcus.
Vaccine 2010;28(31):5023-30.
2010: Anna Kabanova; Roberto Adamo; Daniela Proietti; Francesco Berti; Marta Tontini; Rino Rappuoli; Paolo Costantino
Preparation, characterization and immunogenicity of HIV-1 related high-mannose oligosaccharides-CRM197 glycoconjugates.
Glycoconjugate journal 2010;27(5):501-13.
2010: Davide Serruto; Rino Rappuoli; Maria Scarselli; Piet Gros; Jos A G van Strijp
Molecular mechanisms of complement evasion: learning from staphylococci and meningococci.
Nature reviews. Microbiology 2010;8(6):393-9.
2010: M Lamine Mbow; Ennio De Gregorio; Nicholas Mark Valiante; Rino Rappuoli
New adjuvants for human vaccines.
Current opinion in immunology 2010;22(3):411-6.
2010: Danilo Gomes Moriel; Isabella Bertoldi; Angela Spagnuolo; Sara Marchi; Roberto Rosini; Barbara Nesta; Ilaria Pastorello; Vanja A Mariani Corea; Giulia Torricelli; Elena Cartocci; Silvana Savino; Maria Scarselli; Ulrich Dobrindt; Jörg Hacker; Hervé Tettelin; Luke J Tallon; Steven Sullivan; Lothar H Wieler; Christa Ewers; Derek Pickard; Gordon Dougan; Maria Rita Fontana; Rino Rappuoli; Mariagrazia Pizza; Laura Serino
Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(20):9072-7.
2010: Diana Boraschi; Giuseppe Del Giudice; Catherine Dutel; Bernard Ivanoff; Rino Rappuoli; Beatrix Grubeck-Loebenstein
Ageing and immunity: addressing immune senescence to ensure healthy ageing.
Vaccine 2010;28(21):3627-31.
2010: Antonio Cassone; Rino Rappuoli
Universal vaccines: shifting to one for many.
mBio 2010;1(1):.
2010: Ethan C Settembre; Philip R Dormitzer; Rino Rappuoli
H1N1: can a pandemic cycle be broken?
Science translational medicine 2010;2(24):24ps14.
2010: Carla Bromuro; Maria Romano; Paola Chiani; Francesco Berti; Marta Tontini; Daniela Proietti; Elena Mori; Antonella Torosantucci; paolo costantino; Rino Rappuoli; Antonio Cassone
Beta-glucan-CRM197 conjugates as candidates antifungal vaccines.
Vaccine 2010;28(14):2615-23.
2010: Kate L Seib; Francesca Oriente; Jeannette Adu-Bobie; Paolo Montanari; Francesca Ferlicca; Marzia M Giuliani; Rino Rappuoli; Mariagrazia Pizza; Isabel Delany
Influence of serogroup B meningococcal vaccine antigens on growth and survival of the meningococcus in vitro and in ex vivo and in vivo models of infection.
Vaccine 2010;28(12):2416-27.
2010: Laura Serino; Danilo Gomes Moriel; Rino Rappuoli; Mariagrazia Pizza
Towards a vaccine against Escherichia coli-associated urinary tract infections.
Future microbiology 2010;5(3):351-4.
2010: Esther Tamayo; Jorge Postigo; Jovanna González; Maigualida Fernández-Rey; Marcos Iglesias; Inés Santiuste; Carlo Riccardi; Rino Rappuoli; Giuseppe Del Giudice; Ramón Merino; Jesús Merino
GITR contributes to the systemic adjuvanticity of the Escherichia coli heat-labile enterotoxin.
European journal of immunology 2010;40(3):754-63.
2010: Davide Serruto; Tiziana Spadafina; Laura Ciucchi; Lisa A Lewis; Sanjay Ram; Marta Tontini; Laura Santini; Alessia Biolchi; Kate L Seib; Marzia M Giuliani; John J Donnelly; Francesco Berti; Silvana Savino; Maria Scarselli; Paolo Costantino; J Simon Kroll; Clíona O'Dwyer; Jiazhou Qiu; Andrew G Plaut; Richard Moxon; Rino Rappuoli; Mariagrazia Pizza; Beatrice Aricò
Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3770-5.
2010: Donatella Pietrella; Anna Rachini; Antonella Torosantucci; Paola Chiani; Alistair J P Brown; Francesco Bistoni; Paolo Costantino; Paolo Mosci; Christophe d'Enfert; Rino Rappuoli; Antonio Cassone; Anna Vecchiarelli
A beta-glucan-conjugate vaccine and anti-beta-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique.
Vaccine 2010;28(7):1717-25.
2010: Rino Rappuoli; Duccio Medini; Emilio Siena; Sonia Budroni; Philip R Dormitzer; Giuseppe Del Giudice
Building an insurance against modern pandemics.
Current opinion in investigational drugs (London, England : 2000) 2010;11(2):126-30.
2010: Surender Khurana; Wanida Chearwae; Flora Castellino; Jody Manischewitz; Lisa R King; Agnieszka Honorkiewicz; Michael T Rock; Kathryn M Edwards; Giuseppe Del Giudice; Rino Rappuoli; Hana Golding
Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus.
Science translational medicine 2010;2(15):15ra5.
2010: Yongqun He; Anne S De Groot; Rino Rappuoli; Robert T Chen
Vaccine informatics.
Journal of biomedicine & biotechnology 2010;2010():765762.
2010: Yongqun He; Rino Rappuoli; Anne S De Groot; Robert T Chen
Emerging vaccine informatics.
Journal of biomedicine & biotechnology 2010;2010():218590.
2010: Claudio Donati; N Luisa Hiller; Hervé Tettelin; Alessandro Muzzi; Nicholas J Croucher; Samuel V Angiuoli; Marco Oggioni; Julie C Hotopp; Fen Ze Hu; David R Riley; Antonello Covacci; Tim Mitchell; Stephen D Bentley; Morgens Kilian; Garth D Ehrlich; Rino Rappuoli; E Richard Moxon; Vega Masignani
Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species.
Genome biology 2010;11(10):R107.
2010: Glen Spraggon; Eric Koesema; Maria Scarselli; Enrico Malito; Massimiliano Biagini; Nathalie Norais; Carla Emolo; Michèle Anne Barocchi; Fabiola Giusti; Markus Hilleringmann; Rino Rappuoli; Scott A Lesley; Antonello Covacci; Vega Masignani; Ilaria Ferlenghi
Supramolecular organization of the repetitive backbone unit of the Streptococcus pneumoniae pilus.
PloS one 2010;5(6):e10919.
2009: Giuseppe Del Giudice; Koert J Stittelaar; Geert van Amerongen; James Simon; Albert D M E Osterhaus; Klaus Stöhr; Rino Rappuoli
Seasonal influenza vaccine provides priming for A/H1N1 immunization.
Science translational medicine 2009;1(12):12re1.
2009: Markus Hilleringmann; Philippe Ringler; Shirley A Müller; Gabriella De Angelis; Rino Rappuoli; Ilaria Ferlenghi; Andreas Engel
Molecular architecture of Streptococcus pneumoniae TIGR4 pili.
The EMBO journal 2009;28(24):3921-30.
2009: Mariangela Del Vecchio; Rebecca Pogni; Maria Camilla Baratto; Angela Nobbs; Rino Rappuoli; Mariagrazia Pizza; Enrico Balducci
Identification of an iron-sulfur cluster that modulates the enzymatic activity in NarE, a Neisseria meningitidis ADP-ribosyltransferase.
The Journal of biological chemistry 2009;284(48):33040-7.
2009: George F Santos; Marzia Giuliani; Laura Santini; Jeanette Adu-Bobie; Mariagrazia Pizza; Rino Rappuoli; William Wacknov; John Donnelly
Investigation on the effect of immune selection on resistance to bactericidal antibodies to group B meningococci in vitro.
Clinical and vaccine immunology : CVI 2009;16(11):1693-5.
2009: Isabella Alberini; Elena Del Tordello; Alba Fasolo; Nigel J Temperton; Grazia Galli; Chiara Gentile; Emanuele Montomoli; Anne K Hilbert; Angelika Banzhoff; Giuseppe Del Giudice; John J Donnelly; Rino Rappuoli; Barbara Capecchi
Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses.
Vaccine 2009;27(43):5998-6003.
2009: Rino Rappuoli; Giuseppe Del Giudice; Gary Nabel; Albert D M E Osterhaus; Robin Robinson; David Salisbury; Klaus Stöhr; John J Treanor
Public health. Rethinking influenza.
Science (New York, N.Y.) 2009;326(5949):50.
2009: Kate L Seib; Gordon Dougan; Rino Rappuoli
The key role of genomics in modern vaccine and drug design for emerging infectious diseases.
PLoS genetics 2009;5(10):e1000612.
2009: Michael Bröker; Peter M Dull; Rino Rappuoli; Paolo Costantino
Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages.
Vaccine 2009;27(41):5574-80.
2009: C Daniela Rinaudo; John L Telford; Rino Rappuoli; Kate L Seib
Vaccinology in the genome era.
The Journal of clinical investigation 2009;119(9):2515-25.
2009: Flora Castellino; Grazia Galli; Giuseppe Del Giudice; Rino Rappuoli
Generating memory with vaccination.
European journal of immunology 2009;39(8):2100-5.
2009: Giuseppe Del Giudice; Peter Malfertheiner; Rino Rappuoli
Development of vaccines against Helicobacter pylori.
Expert review of vaccines 2009;8(8):1037-49.
2009: Maria Nasso; Giorgio Fedele; Fabiana Spensieri; Raffaella Palazzo; Paolo Costantino; Rino Rappuoli; Clara Maria Ausiello
Genetically detoxified pertussis toxin induces Th1/Th17 immune response through MAPKs and IL-10-dependent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1892-9.
2009: Claudia Gianfaldoni; Silvia Maccari; Laura Pancotto; Giacomo Rossi; Markus Hilleringmann; Werner Pansegrau; Antonia Sinisi; Monica Moschioni; Vega Masignani; Rino Rappuoli; Giuseppe Del Giudice; Paolo Ruggiero
Sortase A confers protection against Streptococcus pneumoniae in mice.
Infection and immunity 2009;77(7):2957-61.
2009: Davide Serruto; Tiziana Spadafina; Maria Scarselli; Stefania Bambini; Maurizio Comanducci; Sonja Höhle; Mogens Kilian; Esteban Veiga; Pascale Cossart; Marco R Oggioni; Silvana Savino; Ilaria Ferlenghi; Anna Rita Taddei; Rino Rappuoli; Mariagrazia Pizza; Vega Masignani; Beatrice Aricò
HadA is an atypical new multifunctional trimeric coiled-coil adhesin of Haemophilus influenzae biogroup aegyptius, which promotes entry into host cells.
Cellular microbiology 2009;11(7):1044-63.
2009: Shelley Copley; Rino Rappuoli
Genomics of ecology and industrial microbiology.
Current opinion in microbiology 2009;12(3):221-2.
2009: Stefania Bambini; Alessandro Muzzi; Per OlcEn; Rino Rappuoli; Mariagrazia Pizza; Maurizio Comanducci
Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcus.
Vaccine 2009;27(21):2794-803.
2009: Donata Medaglini; Ole F Olesen; Rino Rappuoli
The European effort towards the development of mucosal vaccines for poverty-related diseases.
Vaccine 2009;27(20):2641-8.
2009: Francesca Cantini; Daniele Veggi; Sara Dragonetti; Silvana Savino; Maria Scarselli; Giacomo Romagnoli; Mariagrazia Pizza; Lucia Banci; Rino Rappuoli
Solution structure of the factor H-binding protein, a survival factor and protective antigen of Neisseria meningitidis.
The Journal of biological chemistry 2009;284(14):9022-6.
2009: Grazia Galli; Duccio Medini; Erica Borgogni; Luisanna Zedda; Monia Bardelli; Carmine Malzone; Sandra Nuti; Simona Tavarini; Chiara Sammicheli; Anne K Hilbert; V F H Brauer; Angelika Banzhoff; Rino Rappuoli; Giuseppe Del Giudice; Flora Castellino
Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3877-82.
2009: Susanne Jacobsson; Sara Thulin Hedberg; Paula Mölling; Magnus Unemo; Maurizio Comanducci; Rino Rappuoli; Per Olcén
Prevalence and sequence variations of the genes encoding the five antigens included in the novel 5CVMB vaccine covering group B meningococcal disease.
Vaccine 2009;27(10):1579-84.
2009: Antonello Covacci; Rino Rappuoli
Visualizing bacterial surfaces in real time.
Microbial biotechnology 2009;2(2):146-7.
2009: Stefania Bambini; Rino Rappuoli
The use of genomics in microbial vaccine development.
Drug discovery today 2009;14(5-6):252-60.
2009: Maria Scarselli; Francesca Cantini; Laura Santini; Daniele Veggi; Sara Dragonetti; Claudio Donati; Silvana Savino; Marzia M Giuliani; Maurizio Comanducci; Federica Di Marcello; Giacomo Romagnoli; Mariagrazia Pizza; Lucia Banci; Rino Rappuoli
Epitope mapping of a bactericidal monoclonal antibody against the factor H binding protein of Neisseria meningitidis.
Journal of molecular biology 2009;386(1):97-108.
2009: Esther Tamayo; Jorge Postigo; Giuseppe Del Giudice; Rino Rappuoli; Adalberto Benito; Hideo Yagita; Ramón Merino; Jesús Merino
Involvement of the intrinsic and extrinsic cell-death pathways in the induction of apoptosis of mature lymphocytes by the Escherichia coli heat-labile enterotoxin.
European journal of immunology 2009;39(2):439-46.
2009: Annette Plüddemann; Subhankar Mukhopadhyay; Marko Sankala; Silvana Savino; Mariagrazia Pizza; Rino Rappuoli; Karl Tryggvason; Siamon Gordon
SR-A, MARCO and TLRs differentially recognise selected surface proteins from Neisseria meningitidis: an example of fine specificity in microbial ligand recognition by innate immune receptors.
Journal of innate immunity 2009;1(2):153-63.
2009: Danilo Gomes Moriel; Maria Scarselli; Laura Serino; Marirosa Mora; Rino Rappuoli; Vega Masignani
Genome-based vaccine development: a short cut for the future.
Advances in experimental medicine and biology 2009;655():81-9.
2009: Philip R Dormitzer; Rino Rappuoli; Daniele Casini; Derek O'Hagan; Celene Runham; Emanuele Montomoli; Barbara Baudner; Giulia Lapini; John J Donnelly Iii; Andreas Wack
Adjuvant is necessary for a robust immune response to a single dose of H1N1 pandemic flu vaccine in mice.
PLoS currents 2009;1():RRN1025.
2009: David J M Lewis; Zhiming Huo; Susan Barnett; Ingrid Kromann; Rafaela Giemza; Eva Galiza; Maria Woodrow; Birgit Thierry-Carstensen; Peter Andersen; Deborah Novicki; Giuseppe Del Giudice; Rino Rappuoli
Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin.
PloS one 2009;4(9):e6999.
2008: Mariagrazia Pizza; John Donnelly; Rino Rappuoli
Factor H-binding protein, a unique meningococcal vaccine antigen.
Vaccine 2008;26 Suppl 8():I46-8.
2008: Oretta Finco; Rino Rappuoli
Rediscovering complement, the first barrier of innate immunity.
Vaccine 2008;26 Suppl 8():I1-2.
2008: Nicholas Mark Valiante; Ennio De Gregorio; Rino Rappuoli
Toll-free immunity?
Nature medicine 2008;14(12):1318-9.
2008: Philip R Dormitzer; Jeffrey B Ulmer; Rino Rappuoli
Structure-based antigen design: a strategy for next generation vaccines.
Trends in biotechnology 2008;26(12):659-67.
2008: Aldo Tagliabue; Rino Rappuoli
Vaccine adjuvants: the dream becomes real.
Human vaccines 2008;4(5):347-9.
2008: Peter Malfertheiner; Viola Schultze; Bernd Rosenkranz; Stefan H E Kaufmann; Timo Ulrichs; Deborah Novicki; Francesco Norelli; Mario Contorni; Samuele Peppoloni; Duccio Berti; Daniela Tornese; Jitendra Ganju; Emanuela Palla; Rino Rappuoli; Bruce F Scharschmidt; Giuseppe Del Giudice
Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: a phase I study.
Gastroenterology 2008;135(3):787-95.
2008: Ennio De Gregorio; Elaine Tritto; Rino Rappuoli
Alum adjuvanticity: unraveling a century old mystery.
European journal of immunology 2008;38(8):2068-71.
2008: Fabio Bagnoli; Monica Moschioni; Claudio Donati; Valentina Dimitrovska; Ilaria Ferlenghi; Claudia Facciotti; Alessandro Muzzi; Fabiola Giusti; Carla Emolo; Antonella Sinisi; Markus Hilleringmann; Werner Pansegrau; Stefano Censini; Rino Rappuoli; Antonello Covacci; Vega Masignani; Michele A Barocchi
A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells.
Journal of bacteriology 2008;190(15):5480-92.
2008: F Mosca; E Tritto; A Muzzi; E Monaci; F Bagnoli; C Iavarone; D O'Hagan; Rino Rappuoli; E De Gregorio
Molecular and cellular signatures of human vaccine adjuvants.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(30):10501-6.
2008: Duccio Medini; Davide Serruto; Julian Parkhill; David A Relman; Claudio Donati; Richard Moxon; Stanley Falkow; Rino Rappuoli
Microbiology in the post-genomic era.
Nature reviews. Microbiology 2008;6(6):419-30.
2008: Danilo Gomes Moriel; Maria Scarselli; Laura Serino; Marirosa Mora; Rino Rappuoli; Vega Masignani
Genome-based vaccine development: a short cut for the future.
Human vaccines 2008;4(3):184-8.
2008: Angela Bardotti; Giovanni Averani; Francesco Berti; Stefania Berti; Valeria Carinci; Sandro D'Ascenzi; Barbara Fabbri; Sara Giannini; Aldo Giannozzi; Claudia Magagnoli; Daniela Proietti; Francesco Norelli; Rino Rappuoli; Stefano Ricci; paolo costantino
Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases.
Vaccine 2008;26(18):2284-96.
2008: Ivano Bertini; Silvio Garattini; Rino Rappuoli
Italy must invest more in science and technology.
Nature 2008;452(7188):685.
2008: Paul Stickings; Marisa Peyre; Laura Coombes; Sylviane Muller; Rino Rappuoli; Giuseppe Del Giudice; Charalambos D Partidos; Dorothea Sesardic
Transcutaneous immunization with cross-reacting material CRM(197) of diphtheria toxin boosts functional antibody levels in mice primed parenterally with adsorbed diphtheria toxoid vaccine.
Infection and immunity 2008;76(4):1766-73.
2008: Monica Moschioni; Claudio Donati; Alessandro Muzzi; Vega Masignani; Stefano Censini; William P Hanage; Cynthia J Bishop; Joice Neves Reis; Staffan Normark; Birgitta Henriques Normark; Antonello Covacci; Rino Rappuoli; Michèle A Barocchi
Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related.
The Journal of infectious diseases 2008;197(6):888-96.
2008: Markus Hilleringmann; Fabiola Giusti; Barbara C Baudner; Vega Masignani; Antonello Covacci; Rino Rappuoli; Michèle A Barocchi; Ilaria Ferlenghi
Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A.
PLoS pathogens 2008;4(3):e1000026.
2008: Andreas Wack; Barbara C Baudner; Anne K Hilbert; Ilaria Manini; Sandra Nuti; Simona Tavarini; Hanno Scheffczik; Mildred Ugozzoli; Manmohan Singh; Jina Kazzaz; EMANUELE MONTOMOLI; Giuseppe Del Giudice; Rino Rappuoli; Derek T O'Hagan
Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice.
Vaccine 2008;26(4):552-61.
2008: Allan Saul; Rino Rappuoli
The Novartis Vaccines Institute for Global Health: a new initiative for developing vaccines for neglected diseases in developing countries.
Journal of infection in developing countries 2008;2(2):154-5.
2008: Alessandro Muzzi; Monica Moschioni; Antonello Covacci; Rino Rappuoli; Claudio Donati
Pilus operon evolution in Streptococcus pneumoniae is driven by positive selection and recombination.
PloS one 2008;3(11):e3660.
2007: Rino Rappuoli
Bridging the knowledge gaps in vaccine design.
Nature biotechnology 2007;25(12):1361-6.
2007: Elaine Tritto; Alessandro Muzzi; Isabella Pesce; Elisabetta Monaci; Sandra Nuti; Grazia Galli; Andreas Wack; Rino Rappuoli; Tracy Hussell; Ennio De Gregorio
The acquired immune response to the mucosal adjuvant LTK63 imprints the mouse lung with a protective signature.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5346-57.
2007: Aaron Nelson; J Ries; F Bagnoli; Sofia Dahlberg; S Fälker; S Rounioja; J Tschöp; Eva Morfeldt; Ilaria Ferlenghi; Markus Hilleringmann; D W Holden; Rino Rappuoli; Staffan Normark; Michèle Anne Barocchi; Birgitta Henriques Normark
RrgA is a pilus-associated adhesin in Streptococcus pneumoniae.
Molecular microbiology 2007;66(2):329-40.
2007: Enrico Balducci; Luigi G Micossi; Elisabetta Soldaini; Rino Rappuoli
Expression and selective up-regulation of toxin-related mono ADP-ribosyltransferases by pathogen-associated molecular patterns in alveolar epithelial cells.
FEBS letters 2007;581(22):4199-204.
2007: Rino Rappuoli
An audience with... Rino Rappuoli.
Nature reviews. Drug discovery 2007;6(9):694.
2007: K Sjöström; C Blomberg; Jenny Fernebro; J Dagerhamn; Eva Morfeldt; Michèle Anne Barocchi; S Browall; Monica Moschioni; M Andersson; F Henriques; Barbara Albiger; Rino Rappuoli; Staffan Normark; Birgitta Henriques Normark
Clonal success of piliated penicillin nonsusceptible pneumococci.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12907-12.
2007: Laura Serino; Barbara Nesta; Rosanna Leuzzi; Maria Rita Fontana; Elisabetta Monaci; Brian T Mocca; Elena Cartocci; Vega Masignani; Ann E Jerse; Rino Rappuoli; Mariagrazia Pizza
Identification of a new OmpA-like protein in Neisseria gonorrhoeae involved in the binding to human epithelial cells and in vivo colonization.
Molecular microbiology 2007;64(5):1391-403.
2007: Alessandro Muzzi; Vega Masignani; Rino Rappuoli
The pan-genome: towards a knowledge-based discovery of novel targets for vaccines and antibacterials.
Drug discovery today 2007;12(11-12):429-39.
2007: Michèle Anne Barocchi; Stefano Censini; Rino Rappuoli
Vaccines in the era of genomics: the pneumococcal challenge.
Vaccine 2007;25(16):2963-73.
2007: Francesco Dotta; Stefano Censini; Astrid G S van Halteren; Lorella Marselli; Matilde Masini; Simona Dionisi; Franco Mosca; Ugo Boggi; Andrea Onetti Muda; John Elliott; Antonello Covacci; Rino Rappuoli; Bart O Roep; Stefano Del Prato; Piero Marchetti
Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5115-20.
2007: Grazia Galli; Paola Pittoni; Elena Tonti; Carmine Malzone; Yasushi Uematsu; Marco Tortoli; Domenico Maione; Gianfranco Volpini; Oretta Finco; Sandra Nuti; Simona Tavarini; Paolo Dellabona; Rino Rappuoli; Giulia Casorati; Sergio Abrignani
Invariant NKT cells sustain specific B cell responses and memory.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3984-9.
2007: Claudia Gianfaldoni; Stefano Censini; Markus Hilleringmann; Monica Moschioni; Claudia Facciotti; Werner Pansegrau; Vega Masignani; Antonello Covacci; Rino Rappuoli; Michèle Anne Barocchi; Paolo Ruggiero
Streptococcus pneumoniae pilus subunits protect mice against lethal challenge.
Infection and immunity 2007;75(2):1059-62.
2006: Julie C Hotopp; Renata Grifantini; Nikhil Kumar; Yih-Ling Tzeng; Derrick E Fouts; Elisabetta Frigimelica; Monia Draghi; Marzia M Giuliani; Rino Rappuoli; David S Stephens; Guido Grandi; Hervé Tettelin
Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes.
Microbiology (Reading, England) 2006;152(Pt 12):3733-49.
2006: Atul K Johri; Lawrence C Paoletti; Philippe Glaser; Meenakshi Dua; Puja Kumari Sharma; Guido Grandi; Rino Rappuoli
Group B Streptococcus: global incidence and vaccine development.
Nature reviews. Microbiology 2006;4(12):932-42.
2006: Jeffrey B Ulmer; Ulrich Valley; Rino Rappuoli
Vaccine manufacturing: challenges and solutions.
Nature biotechnology 2006;24(11):1377-83.
2006: Jes Dietrich; Claire Andersen; Rino Rappuoli; T Mark Doherty; Charlotte Green Jensen; Peter Andersen
Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6353-60.
2006: Marirosa Mora; Claudio Donati; Duccio Medini; Antonello Covacci; Rino Rappuoli
Microbial genomes and vaccine design: refinements to the classical reverse vaccinology approach.
Current opinion in microbiology 2006;9(5):532-6.
2006: Giuseppe Del Giudice; Elena Fragapane; Roberto Bugarini; Maninder Hora; Thomas Henriksson; Emanuela Palla; Derek O'Hagan; John Donnelly; Rino Rappuoli; Audino Podda
Vaccines with the MF59 adjuvant do not stimulate antibody responses against squalene.
Clinical and vaccine immunology : CVI 2006;13(9):1010-3.
2006: Leanne Peiser; Katherine Makepeace; Annette Plüddemann; Silvana Savino; Claire Hoe; Mariagrazia Pizza; Rino Rappuoli; E Richard Moxon; Siamon Gordon
Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay.
Infection and immunity 2006;74(9):5191-9.
2006: Fabio Bagnoli; Rino Rappuoli
Targeting infectious diseases in the genomics era.
Current opinion in investigational drugs (London, England : 2000) 2006;7(8):695-8.
2006: Maria Scarselli; Davide Serruto; Paolo Montanari; Barbara Capecchi; Jeannette Adu-Bobie; Daniele Veggi; Rino Rappuoli; Mariagrazia Pizza; Beatrice Aricò
Neisseria meningitidis NhhA is a multifunctional trimeric autotransporter adhesin.
Molecular microbiology 2006;61(3):631-44.
2006: Marzia M Giuliani; Jeannette Adu-Bobie; Maurizio Comanducci; Beatrice Aricò; Silvana Savino; Laura Santini; Brunella Brunelli; Stefania Bambini; Alessia Biolchi; Barbara Capecchi; Elena Cartocci; Laura Ciucchi; Federica Di Marcello; Francesca Ferlicca; Barbara Galli; Enrico Luzzi; Vega Masignani; Davide Serruto; Daniele Veggi; Mario Contorni; Maurizio Morandi; Alessandro Bartalesi; Vanda Cinotti; Donatella Mannucci; Francesca Titta; Elisa Ovidi; Jo Anne Welsch; Dan M Granoff; Rino Rappuoli; Mariagrazia Pizza
A universal vaccine for serogroup B meningococcus.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10834-9.
2006: Alberto Danielli; Davide Roncarati; Isabel Delany; Valentina Chiarini; Rino Rappuoli; Vincenzo Scarlato
In vivo dissection of the Helicobacter pylori Fur regulatory circuit by genome-wide location analysis.
Journal of bacteriology 2006;188(13):4654-62.
2006: John L Telford; Michèle Anne Barocchi; Immaculada Margarit; Rino Rappuoli; Guido Grandi
Pili in gram-positive pathogens.
Nature reviews. Microbiology 2006;4(7):509-19.
2006: Davide Serruto; Rino Rappuoli
Post-genomic vaccine development.
FEBS letters 2006;580(12):2985-92.
2006: Derek T O'Hagan; Rino Rappuoli
Novel approaches to pediatric vaccine delivery.
Advanced drug delivery reviews 2006;58(1):29-51.
2006: Giuseppe Del Giudice; Anne Katrin Hilbert; Roberto Bugarini; Ada Minutello; Olga Popova; daniela toneatto; Ines Schoendorf; Astrid Borkowski; Rino Rappuoli; Audino Podda
An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine.
Vaccine 2006;24(16):3063-5.
2006: Isabel Delany; Renata Grifantini; Erika Bartolini; Rino Rappuoli; Vincenzo Scarlato
Effect of Neisseria meningitidis fur mutations on global control of gene transcription.
Journal of bacteriology 2006;188(7):2483-92.
2006: Francesca Cantini; Silvana Savino; Maria Scarselli; Vega Masignani; Mariagrazia Pizza; Giacomo Romagnoli; Erwin Frans M. Swennen; Daniele Veggi; Lucia Banci; Rino Rappuoli
Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis.
The Journal of biological chemistry 2006;281(11):7220-7.
2006: Susanne Jacobsson; Sara Thulin; Paula Mölling; Magnus Unemo; Maurizio Comanducci; Rino Rappuoli; Per Olcén
Sequence constancies and variations in genes encoding three new meningococcal vaccine candidate antigens.
Vaccine 2006;24(12):2161-8.
2006: Hilde Bakke; Helvi H Samdal; Johan Holst; Fredrik Oftung; Inger Lise Haugen; Anne-Cathrine Kristoffersen; Anita Haugan; Libuse Janakova; Gro Ellen Korsvold; G Krogh; E A S Andersen; Per Gisle Djupesland; T Holand; Rino Rappuoli; Bjørn Haneberg
Oral spray immunization may be an alternative to intranasal vaccine delivery to induce systemic antibodies but not nasal mucosal or cellular immunity.
Scandinavian journal of immunology 2006;63(3):223-31.
2006: Michèle Anne Barocchi; J Ries; X Zogaj; C Hemsley; Barbara Albiger; A Kanth; Sofia Dahlberg; Jenny Fernebro; Monica Moschioni; Vega Masignani; Kjell Hultenby; Annarita Taddei; Katharina Beiter; Florian Wartha; A von Euler; Antonello Covacci; D W Holden; Staffan Normark; Rino Rappuoli; Birgitta Henriques Normark
A pneumococcal pilus influences virulence and host inflammatory responses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2857-62.
2006: Sukumar Pal; Ellena M Peterson; Rino Rappuoli; Giulio Ratti; Luis M de la Maza
Immunization with the Chlamydia trachomatis major outer membrane protein, using adjuvants developed for human vaccines, can induce partial protection in a mouse model against a genital challenge.
Vaccine 2006;24(6):766-75.
2006: Marco Soriani; Isabella Santi; Annarita Taddei; Rino Rappuoli; Guido Grandi; John L Telford
Group B Streptococcus crosses human epithelial cells by a paracellular route.
The Journal of infectious diseases 2006;193(2):241-50.
2005: Rudi Daems; Giuseppe Del Giudice; Rino Rappuoli
Anticipating crisis: towards a pandemic flu vaccination strategy through alignment of public health and industrial policy.
Vaccine 2005;23(50):5732-42.
2005: Zhiming Huo; Ruchi Sinha; Edel A McNeela; Ray Borrow; Rafaela Giemza; Catherine Cosgrove; Paul T Heath; Kingston H G Mills; Rino Rappuoli; George E Griffin; David J M Lewis
Induction of protective serum meningococcal bactericidal and diphtheria-neutralizing antibodies and mucosal immunoglobulin A in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with chitosan.
Infection and immunity 2005;73(12):8256-65.
2005: Esther Tamayo; Ramón Merino; Jovanna González-Rojas; Regina Marquina; Inés Santiuste; José Antonio Amado; Rino Rappuoli; Giuseppe Del Giudice; Jesús Merino
The Escherichia coli heat-labile enterotoxin induces apoptosis of immature lymphocytes in vivo via a glucocorticoid-dependent pathway.
European journal of immunology 2005;35(12):3505-15.
2005: Duccio Medini; Claudio Donati; Hervé Tettelin; Vega Masignani; Rino Rappuoli
The microbial pan-genome.
Current opinion in genetics & development 2005;15(6):589-94.
2005: Konrad Stadler; Rino Rappuoli
SARS: understanding the virus and development of rational therapy.
Current molecular medicine 2005;5(7):677-97.
2005: Susan W Barnett; Indresh K Srivastava; Jeffrey B Ulmer; John J Donnelly; Rino Rappuoli
Development of V2-deleted trimeric envelope vaccine candidates from human immunodeficiency virus type 1 (HIV-1) subtypes B and C.
Microbes and infection / Institut Pasteur 2005;7(14):1386-91.
2005: Isabel Delany; Raffaele Ieva; Alice Soragni; Markus Hilleringmann; Rino Rappuoli; Vincenzo Scarlato
In vitro analysis of protein-operator interactions of the NikR and fur metal-responsive regulators of coregulated genes in Helicobacter pylori.
Journal of bacteriology 2005;187(22):7703-15.
2005: Wing-Pui Kong; Ling Xu; Konrad Stadler; Jeffrey B Ulmer; Sergio Abrignani; Rino Rappuoli; Gary Nabel
Modulation of the immune response to the severe acute respiratory syndrome spike glycoprotein by gene-based and inactivated virus immunization.
Journal of virology 2005;79(22):13915-23.
2005: Rosanna Leuzzi; Laura Serino; Maria Scarselli; Silvana Savino; Maria Rita Fontana; Elisabetta Monaci; Annarita Taddei; Gunter Fischer; Rino Rappuoli; Mariagrazia Pizza
Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages.
Molecular microbiology 2005;58(3):669-81.
2005: Antonella Torosantucci; Carla Bromuro; Paola Chiani; Flavia De Bernardis; Francesco Berti; Chiara Galli; Francesco Norelli; Cinzia Bellucci; Luciano Polonelli; paolo costantino; Rino Rappuoli; Antonio Cassone
A novel glyco-conjugate vaccine against fungal pathogens.
The Journal of experimental medicine 2005;202(5):597-606.
2005: Barbara C Baudner; Jan Verhoef; Marzia M Giuliani; Samuele Peppoloni; Rino Rappuoli; Giuseppe Del Giudice; Hans E Junginger
Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform.
Journal of drug targeting 2005;13(8-9):489-98.
2005: Karin Baraldo; Elena Mori; Antonella Bartoloni; Francesco Norelli; Guido Grandi; Rino Rappuoli; Oretta Finco; Giuseppe Del Giudice
Combined conjugate vaccines: enhanced immunogenicity with the N19 polyepitope as a carrier protein.
Infection and immunity 2005;73(9):5835-41.
2005: Konrad Stadler; Anjeanette Roberts; Stephan Becker; Leatrice Vogel; Markus Eickmann; Larissa Kolesnikova; Hans-Dieter Klenk; Brian Murphy; Rino Rappuoli; Sergio Abrignani; Kanta Subbarao
SARS vaccine protective in mice.
Emerging infectious diseases 2005;11(8):1312-4.
2005: Andreas Wack; Rino Rappuoli
Vaccinology at the beginning of the 21st century.
Current opinion in immunology 2005;17(4):411-8.
2005: Domenico Maione; Immaculada Margarit; Cira Daniela Rinaudo; Vega Masignani; Marirosa Mora; Maria Scarselli; Hervé Tettelin; Cecilia Brettoni; Emilia T Iacobini; Roberto Rosini; Nunzio D'Agostino; Lisa Miorin; Scilla Buccato; Massimo Mariani; Giuliano Galli; Renzo Nogarotto; Vincenzo Nardi Dei; Filipo Vegni; Claire M Fraser-Liggett; Giuseppe Mancuso; Giuseppe Teti; Lawrence C Madoff; Lawrence C Paoletti; Rino Rappuoli; Dennis L Kasper; John L Telford; Vincenzo Nardi-Dei; Guido Grandi
Identification of a universal Group B streptococcus vaccine by multiple genome screen.
Science (New York, N.Y.) 2005;309(5731):148-50.
2005: Peter Lauer; Cira Daniela Rinaudo; Marco Soriani; Immaculada Margarit; Domenico Maione; Roberto Rosini; Annarita Taddei; Marirosa Mora; Rino Rappuoli; Guido Grandi; John L Telford
Genome analysis reveals pili in Group B Streptococcus.
Science (New York, N.Y.) 2005;309(5731):105.
2005: Tiziana Tonini; Rino Rappuoli
[Genome and infectious diseases].
Recenti progressi in medicina 2005;96(5):245-7.
2005: Raffaele Ieva; Cristina Alaimo; Isabel Delany; Gunther Spohn; Rino Rappuoli; Vincenzo Scarlato
CrgA is an inducible LysR-type regulator of Neisseria meningitidis, acting both as a repressor and as an activator of gene transcription.
Journal of bacteriology 2005;187(10):3421-30.
2005: Michèle Anne Barocchi; Vega Masignani; Rino Rappuoli
Opinion: Cell entry machines: a common theme in nature?
Nature reviews. Microbiology 2005;3(4):349-58.
2005: Johan Holst; Berit Feiring; Lisbeth M Naess; Gunnstein Norheim; Paul Kristiansen; E Arne Høiby; Klaus Bryn; Philipp Oster; paolo costantino; Muhamed-Kheir Taha; Jean-Michel Alonso; Dominique A Caugant; Elisabeth Wedege; Ingeborg S Aaberge; Rino Rappuoli; Einar Rosenqvist
The concept of "tailor-made", protein-based, outer membrane vesicle vaccines against meningococcal disease.
Vaccine 2005;23(17-18):2202-5.
2005: Helvi Holm Samdal; Hilde Bakke; Fredrik Oftung; Johan Holst; Inger Lise Haugen; Gro Ellen Korsvold; Anne-Cathrine Kristoffersen; Grethe Krogh; Karin Nord; Rino Rappuoli; Aud Katrine Herland Berstad; Bjørn Haneberg
A non-living nasal influenza vaccine can induce major humoral and cellular immune responses in humans without the need for adjuvants.
Human vaccines 2005;1(2):85-90.
2005: Tiziana Tonini; Susan Barnett; John Donnelly; Rino Rappuoli
Current approaches to developing a preventative HIV vaccine.
Current opinion in investigational drugs (London, England : 2000) 2005;6(2):155-62.
2005: Marzia M Giuliani; Laura Santini; Brunella Brunelli; Alessia Biolchi; Beatrice Aricò; Federica Di Marcello; Elena Cartocci; Maurizio Comanducci; Vega Masignani; Luisa Lozzi; Silvana Savino; Maria Scarselli; Rino Rappuoli; Mariagrazia Pizza
The region comprising amino acids 100 to 255 of Neisseria meningitidis lipoprotein GNA 1870 elicits bactericidal antibodies.
Infection and immunity 2005;73(2):1151-60.
2005: Maria Scarselli; Marzia M Giuliani; Jeannette Adu-Bobie; Mariagrazia Pizza; Rino Rappuoli
The impact of genomics on vaccine design.
Trends in biotechnology 2005;23(2):84-91.
2005: Barbara Capecchi; Jeannette Adu-Bobie; Federica Di Marcello; Laura Ciucchi; Vega Masignani; Annarita Taddei; Rino Rappuoli; Mariagrazia Pizza; Beatrice Aricò
Neisseria meningitidis NadA is a new invasin which promotes bacterial adhesion to and penetration into human epithelial cells.
Molecular microbiology 2005;55(3):687-98.
2005: Dominic F Kelly; Rino Rappuoli
Reverse vaccinology and vaccines for serogroup B Neisseria meningitidis.
Advances in experimental medicine and biology 2005;568():217-23.
2005: Claire M Fraser-Liggett; Rino Rappuoli
Application of microbial genomic science to advanced therapeutics.
Annual review of medicine 2005;56():459-74.
2005: John B Robbins; Rachel Schneerson; Birger Trollfors; Hiroko Sato; Yuji Sato; Rino Rappuoli; Jerry M Keith
The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins.
The Journal of infectious diseases 2005;191(1):81-8.
2004: Andrew Williams; Lorna Edwards; Ian R Humphreys; Robert Snelgrove; Aaron Rae; Rino Rappuoli; Tracy Hussell
Innate imprinting by the modified heat-labile toxin of Escherichia coli (LTK63) provides generic protection against lung infectious disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7435-43.
2004: Rino Rappuoli
From Pasteur to genomics: progress and challenges in infectious diseases.
Nature medicine 2004;10(11):1177-85.
2004: Ennio De Gregorio; Rino Rappuoli
Inside sensors detecting outside pathogens.
Nature immunology 2004;5(11):1099-100.
2004: David J Litt; Silvana Savino; Amanda Beddek; Maurizio Comanducci; Colin Sandiford; Julia Stevens; Michael Levin; Catherine A Ison; Mariagrazia Pizza; Rino Rappuoli; J Simon Kroll
Putative vaccine antigens from Neisseria meningitidis recognized by serum antibodies of young children convalescing after meningococcal disease.
The Journal of infectious diseases 2004;190(8):1488-97.
2004: Derek T O'Hagan; Rino Rappuoli
The safety of vaccines.
Drug discovery today 2004;9(19):846-54.
2004: Hyun Chul Song; Mi-Young Seo; Konrad Stadler; Byoung J Yoo; Qui-Lim Choo; Stephen R Coates; Yasushi Uematsu; Takashi Harada; Catherine E Greer; John M Polo; Piero Pileri; Markus Eickmann; Rino Rappuoli; Sergio Abrignani; Michael Houghton; Jang H Han
Synthesis and characterization of a native, oligomeric form of recombinant severe acute respiratory syndrome coronavirus spike glycoprotein.
Journal of virology 2004;78(19):10328-35.
2004: Davide Serruto; Jeannette Adu-Bobie; Barbara Capecchi; Rino Rappuoli; Mariagrazia Pizza; Vega Masignani
Biotechnology and vaccines: application of functional genomics to Neisseria meningitidis and other bacterial pathogens.
Journal of biotechnology 2004;113(1-3):15-32.
2004: Fatme Mawas; Marisa Peyre; Anne-Sophie Beignon; Laura Frost; Giuseppe Del Giudice; Rino Rappuoli; Sylviane Muller; Dorothea Sesardic; Charalambos D Partidos
Successful induction of protective antibody responses against Haemophilus influenzae type b and diphtheria after transcutaneous immunization with the glycoconjugate polyribosyl ribitol phosphate-cross-reacting material 197 vaccine.
The Journal of infectious diseases 2004;190(6):1177-82.
2004: Derek T O'Hagan; Rino Rappuoli
Novel approaches to vaccine delivery.
Pharmaceutical research 2004;21(9):1519-30.
2004: Karin Baraldo; Elena Mori; Antonella Bartoloni; Roberto Petracca; Aldo Giannozzi; Francesco Norelli; Rino Rappuoli; Guido Grandi; Giuseppe Del Giudice
N19 polyepitope as a carrier for enhanced immunogenicity and protective efficacy of meningococcal conjugate vaccines.
Infection and immunity 2004;72(8):4884-7.
2004: Elisabetta Traggiai; Stephan Becker; Kanta Subbarao; Larissa Kolesnikova; Yasushi Uematsu; Maria Rita Gismondo; Brian Murphy; Rino Rappuoli; Antonio Lanzavecchia
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus.
Nature medicine 2004;10(8):871-5.
2004: Maurizio Comanducci; Stefania Bambini; Dominique A Caugant; Marirosa Mora; Brunella Brunelli; Barbara Capecchi; Laura Ciucchi; Rino Rappuoli; Mariagrazia Pizza
NadA diversity and carriage in Neisseria meningitidis.
Infection and immunity 2004;72(7):4217-23.
2004: Frances Bowe; E C Lavelle; Edel A McNeela; Christine Hale; Simon Clare; Beatrice Arico; Marzia M Giuliani; Aaron Rae; Alan Huett; Rino Rappuoli; Gordon Dougan; Kingston H G Mills
Mucosal vaccination against serogroup B meningococci: induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin.
Infection and immunity 2004;72(7):4052-60.
2004: Maria Lattanzi; Rino Rappuoli
Long-term solutions for the problem of vaccine shortages.
Expert opinion on biological therapy 2004;4(6):989-92.
2004: Giacomo Rossi; Paolo Ruggiero; Samuele Peppoloni; Laura Pancotto; Damiano Fortuna; Laura Lauretti; Gianfranco Volpini; Silvia Mancianti; Michele Corazza; Ennio Taccini; Francesco Di Pisa; Rino Rappuoli; Giuseppe Del Giudice
Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy.
Infection and immunity 2004;72(6):3252-9.
2004: Isabel Delany; Rino Rappuoli; Vincenzo Scarlato
Fur functions as an activator and as a repressor of putative virulence genes in Neisseria meningitidis.
Molecular microbiology 2004;52(4):1081-90.
2004: Gunther Spohn; Alberto Danielli; Davide Roncarati; Isabel Delany; Rino Rappuoli; Vincenzo Scarlato
Dual control of Helicobacter pylori heat shock gene transcription by HspR and HrcA.
Journal of bacteriology 2004;186(10):2956-65.
2004: Marina de Bernard; Andrea Cappon; Giuseppe Del Giudice; Rino Rappuoli; Cesare Montecucco
The multiple cellular activities of the VacA cytotoxin of Helicobacter pylori.
International journal of medical microbiology : IJMM 2004;293(7-8):589-97.
2004: Vega Masignani; Enrico Balducci; Davide Serruto; Daniele Veggi; Beatrice Aricò; Maurizio Comanducci; Mariagrazia Pizza; Rino Rappuoli
In silico identification of novel bacterial ADP-ribosyltransferases.
International journal of medical microbiology : IJMM 2004;293(7-8):471-8.
2004: Giacomo Rossi; Stefano Romagnoli; Laura Lauretti; Laura Pancotto; Ennio Taccini; Rino Rappuoli; Giuseppe Del Giudice; Paolo Ruggiero
Helicobacter pylori infection negatively influences pregnancy outcome in a mouse model.
Helicobacter 2004;9(2):152-7.
2004: Jeannette Adu-Bobie; Pietro Lupetti; Brunella Brunelli; Dan M Granoff; Nathalie Norais; Germano Ferrari; Guido Grandi; Rino Rappuoli; Mariagrazia Pizza
GNA33 of Neisseria meningitidis is a lipoprotein required for cell separation, membrane architecture, and virulence.
Infection and immunity 2004;72(4):1914-9.
2004: Barbara C Baudner; Maurizio Morandi; Marzia M Giuliani; Jan Verhoef; Hans E Junginger; paolo costantino; Rino Rappuoli; Giuseppe Del Giudice
Modulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery system.
The Journal of infectious diseases 2004;189(5):828-32.
2004: Edel A McNeela; Inderjit Jabbal-Gill; Lisbeth Illum; Mariagrazia Pizza; Rino Rappuoli; Audino Podda; David J M Lewis; Kingston H G Mills
Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: enhancement of Th2 responses and toxin-neutralizing antibodies by formulation with chitosan.
Vaccine 2004;22(8):909-14.
2004: Anne S De Groot; Rino Rappuoli
Genome-derived vaccines.
Expert review of vaccines 2004;3(1):59-76.
2004: Rogerio P Mazzantini; Eliane N Miyaji; Waldely O Dias; Dirce Sakauchi; Ana L T O Nascimento; Isaias Raw; Nathalie Winter; Brigitte Gicquel; Rino Rappuoli; Luciana C C Leite
Adjuvant activity of Mycobacterium bovis BCG expressing CRM197 on the immune response induced by BCG expressing tetanus toxin fragment C.
Vaccine 2004;22(5-6):740-6.
2004: J Daniel Dubreuil; Paolo Ruggiero; Rino Rappuoli; Giuseppe Del Giudice
Effect of heparin binding on Helicobacter pylori resistance to serum.
Journal of medical microbiology 2004;53(Pt 1):9-12.
2004: Barbara Capecchi; Davide Serruto; Jeannette Adu-Bobie; Rino Rappuoli; Mariagrazia Pizza
The genome revolution in vaccine research.
Current issues in molecular biology 2004;6(1):17-27.
2003: Konrad Stadler; Vega Masignani; Markus Eickmann; Stephan Becker; Sergio Abrignani; Hans-Dieter Klenk; Rino Rappuoli
SARS--beginning to understand a new virus.
Nature reviews. Microbiology 2003;1(3):209-18.
2003: Jo Anne Welsch; Gregory R Moe; Raffaella Rossi; Jeannette Adu-Bobie; Rino Rappuoli; Dan M Granoff
Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity.
The Journal of infectious diseases 2003;188(11):1730-40.
2003: Markus Eickmann; Stephan Becker; Hans-Dieter Klenk; Hans Wilhelm Doerr; Konrad Stadler; Stefano Censini; Silvia Guidotti; Vega Masignani; Maria Scarselli; Marirosa Mora; Claudio Donati; Jang H Han; Hyun Chul Song; Sergio Abrignani; Antonello Covacci; Rino Rappuoli
Phylogeny of the SARS coronavirus.
Science (New York, N.Y.) 2003;302(5650):1504-5.
2003: Isabel Delany; Gunther Spohn; Rino Rappuoli; Vincenzo Scarlato
An anti-repression Fur operator upstream of the promoter is required for iron-mediated transcriptional autoregulation in Helicobacter pylori.
Molecular microbiology 2003;50(4):1329-38.
2003: Vega Masignani; Enrico Balducci; Federica Di Marcello; Silvana Savino; Davide Serruto; Daniele Veggi; Stefania Bambini; Maria Scarselli; Beatrice Aricò; Maurizio Comanducci; Jeannette Adu-Bobie; Marzia M Giuliani; Rino Rappuoli; Mariagrazia Pizza
NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis.
Molecular microbiology 2003;50(3):1055-67.
2003: Rino Rappuoli; Antonello Covacci
Reverse vaccinology and genomics.
Science (New York, N.Y.) 2003;302(5645):602.
2003: Isabel Delany; Raffaele Ieva; Cristina Alaimo; Rino Rappuoli; Vincenzo Scarlato
The iron-responsive regulator fur is transcriptionally autoregulated and not essential in Neisseria meningitidis.
Journal of bacteriology 2003;185(20):6032-41.
2003: Mariarosaria Marinaro; Antonella Riccomi; Rino Rappuoli; Mariagrazia Pizza; Valeria Fiorelli; Antonella Tripiciano; Aurelio Aurelio Cafaro; Barbara Ensoli; Maria Teresa De Magistris
Mucosal delivery of the human immunodeficiency virus-1 Tat protein in mice elicits systemic neutralizing antibodies, cytotoxic T lymphocytes and mucosal IgA.
Vaccine 2003;21(25-26):3972-81.
2003: Barbara C Baudner; Marzia M Giuliani; Jan Verhoef; Rino Rappuoli; Hans E Junginger; Giuseppe Del Giudice
The concomitant use of the LTK63 mucosal adjuvant and of chitosan-based delivery system enhances the immunogenicity and efficacy of intranasally administered vaccines.
Vaccine 2003;21(25-26):3837-44.
2003: Robert Tierney; Anne-Sophie Beignon; Rino Rappuoli; Sylviane Muller; Dorothea Sesardic; Charalambos D Partidos
Transcutaneous immunization with tetanus toxoid and mutants of Escherichia coli heat-labile enterotoxin as adjuvants elicits strong protective antibody responses.
The Journal of infectious diseases 2003;188(5):753-8.
2003: Renata Grifantini; Shite Sebastian; Elisabetta Frigimelica; Monia Draghi; Erika Bartolini; Alessandro Muzzi; Rino Rappuoli; Guido Grandi; Caroline Attardo Genco
Identification of iron-activated and -repressed Fur-dependent genes by transcriptome analysis of Neisseria meningitidis group B.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9542-7.
2003: Jeffrey B Ulmer; Rino Rappuoli
DNA vaccination.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2003;Chapter 13():Unit 13.2.
2003: Rino Rappuoli
The real cost of an affordable vaccine for meningococcus A.
Lancet 2003;362(9379):250-1; author reply 251.
2003: Beatriz Passerini; Laura E Friedman; Cora B Belzoni; Silvana Savino; Beatrice Aricò; Rino Rappuoli; Vega Masignani; Mirta A Franco
Vir90, a virulence-activated gene coding for a Bordetella pertussis iron-regulated outer membrane protein.
Research in microbiology 2003;154(6):443-50.
2003: Paolo Ruggiero; Samuele Peppoloni; Rino Rappuoli; Giuseppe Del Giudice
The quest for a vaccine against Helicobacter pylori: how to move from mouse to man?
Microbes and infection / Institut Pasteur 2003;5(8):749-56.
2003: Vega Masignani; Maria Lattanzi; Rino Rappuoli
The value of vaccines.
Vaccine 2003;21 Suppl 2():S110-3.
2003: Diana Boraschi; Aldo Tagliabue; Michael U Martin; Rino Rappuoli
INNAMORA, a European Workshop focussed on the mechanisms of innate immunity in pathogen-host interaction and their exploitation in novel mucosal immunisation strategies.
Vaccine 2003;21 Suppl 2():S1-11.
2003: Marirosa Mora; Daniele Veggi; Laura Santini; Mariagrazia Pizza; Rino Rappuoli
Reverse vaccinology.
Drug discovery today 2003;8(10):459-64.
2003: Antonello Covacci; Rino Rappuoli
Helicobacter pylori: after the genomes, back to biology.
The Journal of experimental medicine 2003;197(7):807-11.
2003: Samuele Peppoloni; Paolo Ruggiero; Mario Contorni; Maurizio Morandi; Mariagrazia Pizza; Rino Rappuoli; Audino Podda; Giuseppe Del Giudice
Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines.
Expert review of vaccines 2003;2(2):285-93.
2003: Davide Serruto; Jeannette Adu-Bobie; Maria Scarselli; Daniele Veggi; Mariagrazia Pizza; Rino Rappuoli; Beatrice Aricò
Neisseria meningitidis App, a new adhesin with autocatalytic serine protease activity.
Molecular microbiology 2003;48(2):323-34.
2003: Hiroaki Nishioka; Ilenia Baesso; Gianpietro Semenzato; Livio Trentin; Rino Rappuoli; Giuseppe Del Giudice; Cesare Montecucco
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils.
European journal of immunology 2003;33(4):840-9.
2003: Vega Masignani; Maurizio Comanducci; Marzia M Giuliani; Stefania Bambini; Jeannette Adu-Bobie; Beatrice Arico; Brunella Brunelli; Alessandro Pieri; Laura Santini; Silvana Savino; Davide Serruto; David Litt; Simon Kroll; Jo Anne Welsch; Dan M Granoff; Rino Rappuoli; Mariagrazia Pizza
Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870.
The Journal of experimental medicine 2003;197(6):789-99.
2003: Kingston H G Mills; Catherine Cosgrove; Edel A McNeela; Amy Sexton; Rafaela Giemza; Inderjit Jabbal-Gill; Anne Church; Wu Lin; Lisbeth Illum; Audino Podda; Rino Rappuoli; Mariagrazia Pizza; George E Griffin; David J M Lewis
Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a.
Infection and immunity 2003;71(2):726-32.
2003: Jeannette Adu-Bobie; Barbara Capecchi; Davide Serruto; Rino Rappuoli; Mariagrazia Pizza
Two years into reverse vaccinology.
Vaccine 2003;21(7-8):605-10.
2003: Mariagrazia Pizza; Maria Rita Fontana; Vincenzo Scarlato; Rino Rappuoli
Genetic detoxification of bacterial toxins.
Methods in molecular medicine 2003;87():133-52.
2002: Vega Masignani; Rino Rappuoli; Mariagrazia Pizza
Reverse vaccinology: a genome-based approach for vaccine development.
Expert opinion on biological therapy 2002;2(8):895-905.
2002: J Daniel Dubreuil; Giuseppe Del Giudice; Rino Rappuoli
Helicobacter pylori interactions with host serum and extracellular matrix proteins: potential role in the infectious process.
Microbiology and molecular biology reviews : MMBR 2002;66(4):617-29, table of contents.
2002: Isabel Delany; Gunther Spohn; Ana B F Pacheco; Raffaele Ieva; Cristina Alaimo; Rino Rappuoli; Vincenzo Scarlato
Autoregulation of Helicobacter pylori Fur revealed by functional analysis of the iron-binding site.
Molecular microbiology 2002;46(4):1107-22.
2002: Anke Seydel; Elisabetta Tasca; Duccio Berti; Rino Rappuoli; Giuseppe Del Giudice; Cesare Montecucco
Characterization and immunogenicity of the CagF protein of the cag pathogenicity island of Helicobacter pylori.
Infection and immunity 2002;70(11):6468-70.
2002: Giuseppe Zanotti; Elena Papinutto; William G Dundon; Roberto Battistutta; Michela Seveso; Giuseppe Giudice; Rino Rappuoli; Cesare Montecucco
Structure of the neutrophil-activating protein from Helicobacter pylori.
Journal of molecular biology 2002;323(1):125-30.
2002: Samuele Peppoloni; Silvia Mancianti; Gianfranco Volpini; Sandra Nuti; Paolo Ruggiero; Rino Rappuoli; Elisabetta Blasi; Giuseppe Del Giudice
Antibody-dependent macrophage-mediated activity against Helicobacter pylori in the absence of complement.
European journal of immunology 2002;32(10):2721-5.
2002: Barbara C Baudner; O Balland; Marzia M Giuliani; Paul von Hoegen; Rino Rappuoli; D Betbeder; Giuseppe Del Giudice
Enhancement of protective efficacy following intranasal immunization with vaccine plus a nontoxic LTK63 mutant delivered with nanoparticles.
Infection and immunity 2002;70(9):4785-90.
2002: Renata Grifantini; Erika Bartolini; Alessandro Muzzi; Monia Draghi; Elisabetta Frigimelica; Joel Berger; Giulio Ratti; Roberto Petracca; Giuliano Galli; Mauro Agnusdei; Marzia M Giuliani; Laura Santini; Brunella Brunelli; Hervé Tettelin; Rino Rappuoli; Filippo Randazzo; Guido Grandi
Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays.
Nature biotechnology 2002;20(9):914-21.
2002: Isabel Delany; Gunther Spohn; Rino Rappuoli; Vincenzo Scarlato
Growth phase-dependent regulation of target gene promoters for binding of the essential orphan response regulator HP1043 of Helicobacter pylori.
Journal of bacteriology 2002;184(17):4800-10.
2002: Rino Rappuoli; Henry I Miller; Stanley Falkow
Medicine. The intangible value of vaccination.
Science (New York, N.Y.) 2002;297(5583):937-9.
2002: Gary T Jennings; Silvana Savino; Elisa Marchetti; Beatrice Aricò; Thomas Kast; Lucia Baldi; Astrid Ursinus; Joachim-Volker Höltje; Robert A Nicholas; Rino Rappuoli; Guido Grandi
GNA33 from Neisseria meningitidis serogroup B encodes a membrane-bound lytic transglycosylase (MltA).
European journal of biochemistry / FEBS 2002;269(15):3722-31.
2002: Paolo Ruggiero; Samuele Peppoloni; Duccio Berti; Rino Rappuoli; Giuseppe Del Giudice
New strategies for the prevention and treatment of Helicobacter pylori infection.
Expert opinion on investigational drugs 2002;11(8):1127-38.
2002: Maurizio Comanducci; Stefania Bambini; Brunella Brunelli; Jeannette Adu-Bobie; Beatrice Aricò; Barbara Capecchi; Marzia M Giuliani; Vega Masignani; Laura Santini; Silvana Savino; Dan M Granoff; Dominique A Caugant; Mariagrazia Pizza; Rino Rappuoli; Marirosa Mora
NadA, a novel vaccine candidate of Neisseria meningitidis.
The Journal of experimental medicine 2002;195(11):1445-54.
2002: Anne-Sophie Beignon; Jean-Paul Briand; Rino Rappuoli; Sylviane Muller; Charalambos D Partidos
The LTR72 mutant of heat-labile enterotoxin of Escherichia coli enhances the ability of peptide antigens to elicit CD4(+) T cells and secrete gamma interferon after coapplication onto bare skin.
Infection and immunity 2002;70(6):3012-9.
2002: Gunther Spohn; Isabel Delany; Rino Rappuoli; Vincenzo Scarlato
Characterization of the HspR-mediated stress response in Helicobacter pylori.
Journal of bacteriology 2002;184(11):2925-30.
2002: Marta Marchetti; Rino Rappuoli
Isogenic mutants of the cag pathogenicity island of Helicobacter pylori in the mouse model of infection: effects on colonization efficiency.
Microbiology (Reading, England) 2002;148(Pt 5):1447-56.
2002: Pasqualina Montemurro; Hiroaki Nishioka; William G Dundon; Marina de Bernard; Giuseppe Del Giudice; Rino Rappuoli; Cesare Montecucco
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells.
European journal of immunology 2002;32(3):671-6.
2002: Markus Stein; Fabio Bagnoli; Robert Halenbeck; Rino Rappuoli; Wendy J Fantl; Antonello Covacci
c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs.
Molecular microbiology 2002;43(4):971-80.
2002: William G Dundon; Hiroaki Nishioka; Alessandra Polenghi; Elena Papinutto; Giuseppe Zanotti; Pasqualina Montemurro; Giudice Giuseppe Del; Rino Rappuoli; Cesare Montecucco
The neutrophil-activating protein of Helicobacter pylori.
International journal of medical microbiology : IJMM 2002;291(6-7):545-50.
2002: Isabel Delany; Gunther Spohn; Rino Rappuoli; Vincenzo Scarlato
In vitro selection of high affinity HspR-binding sites within the genome of Helicobacter pylori.
Gene 2002;283(1-2):63-9.
2002: Xuhuai Ji; Francesco Frati; Silvia Barone; Cristina Pagliaccia; Daniela Burroni; Guoming Xu; Rino Rappuoli; Reyrat Jean-Marc; John L Telford
Evolution of functional polymorphism in the gene coding for the Helicobacter pylori cytotoxin.
FEMS microbiology letters 2002;206(2):253-8.
2002: Richard Moxon; Rino Rappuoli
Bacterial pathogen genomics and vaccines.
British medical bulletin 2002;62():45-58.
2001: Isabel Delany; Gunther Spohn; Rino Rappuoli; Vincenzo Scarlato
The Fur repressor controls transcription of iron-activated and -repressed genes in Helicobacter pylori.
Molecular microbiology 2001;42(5):1297-309.
2001: Fabiana Falugi; Roberto Petracca; Massimo Mariani; E Luzzi; Silvia Mancianti; V Carinci; M L Melli; Oretta Finco; Andreas Wack; A Di Tommaso; Maria Teresa De Magistris; paolo costantino; Giuseppe Del Giudice; Sergio Abrignani; Rino Rappuoli; Guido Grandi
Rationally designed strings of promiscuous CD4(+) T cell epitopes provide help to Haemophilus influenzae type b oligosaccharide: a model for new conjugate vaccines.
European journal of immunology 2001;31(12):3816-24.
2001: Dan M Granoff; Gregory R Moe; Marzia M Giuliani; Jeannette Adu-Bobie; Laura Santini; Brunella Brunelli; F Piccinetti; Patricia Zuno-Mitchell; S S Lee; P Neri; Luisa Bracci; Luisa Lozzi; Rino Rappuoli
A novel mimetic antigen eliciting protective antibody to Neisseria meningitidis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6487-96.
2001: Laura Morbiato; Francesco Tombola; Silvia Campello; Giuseppe Del Giudice; Rino Rappuoli; Mario Zoratti; Emanuele Papini
Vacuolation induced by VacA toxin of Helicobacter pylori requires the intracellular accumulation of membrane permeant bases, Cl(-) and water.
FEBS letters 2001;508(3):479-83.
2001: Giuseppe Del Giudice; Audino Podda; Rino Rappuoli
What are the limits of adjuvanticity?
Vaccine 2001;20 Suppl 1():S38-41.
2001: Francesco Tombola; Laura Morbiato; Giuseppe Del Giudice; Rino Rappuoli; Mario Zoratti; Emanuele Papini
The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia.
The Journal of clinical investigation 2001;108(6):929-37.
2001: Isabel Delany; Ana B F Pacheco; Gunther Spohn; Rino Rappuoli; Vincenzo Scarlato
Iron-dependent transcription of the frpB gene of Helicobacter pylori is controlled by the Fur repressor protein.
Journal of bacteriology 2001;183(16):4932-7.
2001: William G Dundon; H Nishioka; Cesare Montecucco; Pasqualina Montemurro; Rino Rappuoli; G Del Giudice
Problems assaying neutrophil activators.
Trends in microbiology 2001;9(7):314-5.
2001: C Montecucco; Rino Rappuoli
Living dangerously: how Helicobacter pylori survives in the human stomach.
Nature reviews. Molecular cell biology 2001;2(6):457-66.
2001: William G Dundon; Alessandra Polenghi; G Del Guidice; Rino Rappuoli; Cesare Montecucco
Neutrophil-activating protein (HP-NAP) versus ferritin (Pfr): comparison of synthesis in Helicobacter pylori.
FEMS microbiology letters 2001;199(1):143-9.
2001: Vega Masignani; Marzia M Giuliani; Hervé Tettelin; Maurizio Comanducci; Rino Rappuoli; Vincenzo Scarlato
Mu-like Prophage in serogroup B Neisseria meningitidis coding for surface-exposed antigens.
Infection and immunity 2001;69(4):2580-8.
2001: Pasqualina Montemurro; Giovanna Barbuti; William G Dundon; Giuseppe Del Giudice; Rino Rappuoli; Mario Colucci; Pietro De Rinaldis; Cesare Montecucco; Nicola Semeraro; Emanuele Papini
Helicobacter pylori neutrophil-activating protein stimulates tissue factor and plasminogen activator inhibitor-2 production by human blood mononuclear cells.
The Journal of infectious diseases 2001;183(7):1055-62.
2001: Mariagrazia Pizza; Marzia M Giuliani; Maria Rita Fontana; Elisabetta Monaci; G Douce; Gordon Dougan; Kingston H G Mills; Rino Rappuoli; Giuseppe Del Giudice
Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.
Vaccine 2001;19(17-19):2534-41.
2001: Eliane N Miyaji; Rogerio P Mazzantini; Waldely O Dias; Ana L T O Nascimento; R Marcovistz; D S Matos; Isaias Raw; Nathalie Winter; Brigitte Gicquel; Rino Rappuoli; Luciana C C Leite
Induction of neutralizing antibodies against diphtheria toxin by priming with recombinant Mycobacterium bovis BCG expressing CRM(197), a mutant diphtheria toxin.
Infection and immunity 2001;69(2):869-74.
2001: M Scarselli; Rino Rappuoli; Vincenzo Scarlato
A common conserved amino acid motif module shared by bacterial and intercellular adhesins: bacterial adherence mimicking cell cell recognition?
Microbiology (Reading, England) 2001;147(Pt 2):250-2.
2001: Giuseppe Del Giudice; Antonello Covacci; John L Telford; C Montecucco; Rino Rappuoli
The design of vaccines against Helicobacter pylori and their development.
Annual review of immunology 2001;19():523-63.
2000: Edel A McNeela; D O'Connor; Inderjit Jabbal-Gill; Lisbeth Illum; Stanley S Davis; Mariagrazia Pizza; Samuele Peppoloni; Rino Rappuoli; Kingston H G Mills
A mucosal vaccine against diphtheria: formulation of cross reacting material (CRM(197)) of diphtheria toxin with chitosan enhances local and systemic antibody and Th2 responses following nasal delivery.
Vaccine 2000;19(9-10):1188-98.
2000: Rino Rappuoli
Pushing the limits of cellular microbiology: microarrays to study bacteria-host cell intimate contacts.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13467-9.
2000: Elizabeth Ryan; Edel A McNeela; Mariagrazia Pizza; Rino Rappuoli; L O'Neill; Kingston H G Mills
Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5750-9.
2000: Mariagrazia Pizza; Marzia M Giuliani; Maria Rita Fontana; G Douce; Gordon Dougan; Rino Rappuoli
LTK63 and LTR72, two mucosal adjuvants ready for clinical trials.
International journal of medical microbiology : IJMM 2000;290(4-5):455-61.
2000: Rino Rappuoli
Reverse vaccinology.
Current opinion in microbiology 2000;3(5):445-50.
2000: I P Nascimento; Waldely O Dias; Rogerio P Mazzantini; Eliane N Miyaji; Marcia Gamberini; Wagner Quintilio; Vera C Gebara; D F Cardoso; Paulo Lee Ho; Isaias Raw; Nathalie Winter; Brigitte Gicquel; Rino Rappuoli; Luciana C C Leite
Recombinant Mycobacterium bovis BCG expressing pertussis toxin subunit S1 induces protection against an intracerebral challenge with live Bordetella pertussis in mice.
Infection and immunity 2000;68(9):4877-83.
2000: Maria Rita Fontana; Elisabetta Monaci; L Yanqing; Q Guoming; G Duan; Rino Rappuoli; Mariagrazia Pizza
IEM101, a naturally attenuated Vibrio cholerae strain as carrier for genetically detoxified derivatives of cholera toxin.
Vaccine 2000;19(1):75-85.
2000: Giacomo Rossi; Damiano Fortuna; Laura Pancotto; G Renzoni; Ennio Taccini; P Ghiara; Rino Rappuoli; Giuseppe Del Giudice
Immunohistochemical study of lymphocyte populations infiltrating the gastric mucosa of beagle dogs experimentally infected with Helicobacter pylori.
Infection and immunity 2000;68(8):4769-72.
2000: Xuhuai Ji; T Fernandez; Daniela Burroni; Cristina Pagliaccia; J C Atherton; Reyrat Jean-Marc; Rino Rappuoli; John L Telford
Cell specificity of Helicobacter pylori cytotoxin is determined by a short region in the polymorphic midregion.
Infection and immunity 2000;68(6):3754-7.
2000: B Satin; Giuseppe Del Giudice; V Della Bianca; S Dusi; C Laudanna; Fiorella Tonello; D Kelleher; Rino Rappuoli; Cesare Montecucco; F Rossi
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor.
The Journal of experimental medicine 2000;191(9):1467-76.
2000: A Covacci; Rino Rappuoli
Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell.
The Journal of experimental medicine 2000;191(4):587-92.
2000: Marina de Bernard; Monica Moschioni; G Napolitani; Rino Rappuoli; Cesare Montecucco
The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein.
The EMBO journal 2000;19(1):48-56.
2000: C Ceccarini; Mario Contorni; paolo costantino; Sandro D'Ascenzi; E Gallo; M Maffei; Donatella Mannucci; I Marsili; C Magagnoli; Samuele Peppoloni; Rino Rappuoli; Neil Ravenscroft; Stefano Ricci
Physicochemical characterisation of the pertussis vaccine.
Developments in biologicals 2000;103():175-88.
1999: Cameron P Simmons; Pietro Mastroeni; R Fowler; Marjan Ghaem-Maghami; N Lycke; Mariagrazia Pizza; Rino Rappuoli; Gordon Dougan
MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6502-10.
1999: Elizabeth Ryan; Edel A McNeela; G A Murphy; H Stewart; D O'hagan; Mariagrazia Pizza; Rino Rappuoli; Kingston H G Mills
Mutants of Escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: differential effects of the nontoxic AB complex and enzyme activity on Th1 and Th2 cells.
Infection and immunity 1999;67(12):6270-80.
1999: Rino Rappuoli; Mariagrazia Pizza; G Douce; Gordon Dougan
Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins.
Immunology today 1999;20(11):493-500.
1999: Ildikò Szabò; S Brutsche; Francesco Tombola; Monica Moschioni; B Satin; John L Telford; Rino Rappuoli; Cesare Montecucco; Emanuele Papini; Mario Zoratti
Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity.
The EMBO journal 1999;18(20):5517-27.
1999: Fiorella Tonello; William G Dundon; B Satin; M Molinari; Giuseppe Tognon; G Grandi; Giuseppe Del Giudice; Rino Rappuoli; Cesare Montecucco
The Helicobacter pylori neutrophil-activating protein is an iron-binding protein with dodecameric structure.
Molecular microbiology 1999;34(2):238-46.
1999: Reyrat Jean-Marc; Vladimir Pelicic; Emanuele Papini; C Montecucco; Rino Rappuoli; John L Telford
Towards deciphering the Helicobacter pylori cytotoxin.
Molecular microbiology 1999;34(2):197-204.
1999: G Douce; V Giannelli; Mariagrazia Pizza; D Lewis; Paul Everest; Rino Rappuoli; Gordon Dougan
Genetically detoxified mutants of heat-labile toxin from Escherichia coli are able to act as oral adjuvants.
Infection and immunity 1999;67(9):4400-6.
1999: Vladimir Pelicic; Reyrat Jean-Marc; Leonardo Sartori; Cristina Pagliaccia; Rino Rappuoli; John L Telford; Cesare Montecucco; Emanuele Papini
Helicobacter pylori VacA cytotoxin associated with the bacteria increases epithelial permeability independently of its vacuolating activity.
Microbiology (Reading, England) 1999;145 ( Pt 8)():2043-50.
1999: Reyrat Jean-Marc; Salvatore Lanzavecchia; Pietro Lupetti; Marina de Bernard; Cristina Pagliaccia; Vladimir Pelicic; M Charrel; Cristina Ulivieri; Nathalie Norais; Xuhuai Ji; Véronique Cabiaux; Emanuele Papini; Rino Rappuoli; John L Telford
3D imaging of the 58 kDa cell binding subunit of the Helicobacter pylori cytotoxin.
Journal of molecular biology 1999;290(2):459-70.
1999: Giacomo Rossi; M Rossi; Claudio Vitali; Damiano Fortuna; D Burroni; Laura Pancotto; S Capecchi; S Sozzi; G Renzoni; G Braca; Giuseppe Del Giudice; Rino Rappuoli; P Ghiara; Ennio Taccini
A conventional beagle dog model for acute and chronic infection with Helicobacter pylori.
Infection and immunity 1999;67(6):3112-20.
1999: Antonello Covacci; John L Telford; G Del Giudice; Julie Parsonnet; Rino Rappuoli
Helicobacter pylori virulence and genetic geography.
Science (New York, N.Y.) 1999;284(5418):1328-33.
1999: paolo costantino; Francesco Norelli; Aldo Giannozzi; Sandro D'Ascenzi; Antonella Bartoloni; S Kaur; D Tang; R Seid; S Viti; R Paffetti; M Bigio; C Pennatini; Giovanni Averani; V Guarnieri; E Gallo; Neil Ravenscroft; C Lazzeroni; Rino Rappuoli; C Ceccarini
Size fractionation of bacterial capsular polysaccharides for their use in conjugate vaccines.
Vaccine 1999;17(9-10):1251-63.
1998: Marina de Bernard; Daniela Burroni; Emanuele Papini; Rino Rappuoli; J Telford; Cesare Montecucco
Identification of the Helicobacter pylori VacA toxin domain active in the cell cytosol.
Infection and immunity 1998;66(12):6014-6.
1998: Inderjit Jabbal-Gill; AN Fisher; Rino Rappuoli; Stanley S Davis; Lisbeth Illum
Stimulation of mucosal and systemic antibody responses against Bordetella pertussis filamentous haemagglutinin and recombinant pertussis toxin after nasal administration with chitosan in mice.
Vaccine 1998;16(20):2039-46.
1998: Daniela Burroni; Pietro Lupetti; Cristina Pagliaccia; Reyrat Jean-Marc; Romano Dallai; Rino Rappuoli; John L Telford
Deletion of the major proteolytic site of the Helicobacter pylori cytotoxin does not influence toxin activity but favors assembly of the toxin into hexameric structures.
Infection and immunity 1998;66(11):5547-50.
1998: Marina de Bernard; Monica Moschioni; Emanuele Papini; J Telford; Rino Rappuoli; Cesare Montecucco
Cell vacuolization induced by Helicobacter pylori VacA toxin: cell line sensitivity and quantitative estimation.
Toxicology letters 1998;99(2):109-15.
1998: Marina de Bernard; Monica Moschioni; Emanuele Papini; John L Telford; Rino Rappuoli; Cesare Montecucco
TPA and butyrate increase cell sensitivity to the vacuolating toxin of Helicobacter pylori.
FEBS letters 1998;436(2):218-22.
1998: Giuseppe Del Giudice; P Ghiara; Rino Rappuoli
Experimental model of Helicobacter pylori infection.
Italian journal of gastroenterology and hepatology 1998;30 Suppl 3():S261-3.
1998: Dagmar Beier; Gunther Spohn; Rino Rappuoli; Vincenzo Scarlato
Functional analysis of the Helicobacter pylori principal sigma subunit of RNA polymerase reveals that the spacer region is important for efficient transcription.
Molecular microbiology 1998;30(1):121-34.
1998: Cristina Pagliaccia; Marina de Bernard; Pietro Lupetti; Xuhuai Ji; Daniela Burroni; T L Cover; Emanuele Papini; Rino Rappuoli; John L Telford; Reyrat Jean-Marc
The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10212-7.
1998: Emanuele Papini; B Satin; Nathalie Norais; Marina de Bernard; John L Telford; Rino Rappuoli; Cesare Montecucco
Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.
The Journal of clinical investigation 1998;102(4):813-20.
1998: Reyrat Jean-Marc; M Charrel; Cristina Pagliaccia; Daniela Burroni; Pietro Lupetti; Marina de Bernard; Xuhuai Ji; Nathalie Norais; Emanuele Papini; Romano Dallai; Rino Rappuoli; John L Telford
Characterisation of a monoclonal antibody and its use to purify the cytotoxin of Helicobacter pylori.
FEMS microbiology letters 1998;165(1):79-84.
1998: P Massari; Roberto Manetti; Daniela Burroni; Sandra Nuti; Nathalie Norais; Rino Rappuoli; John L Telford
Binding of the Helicobacter pylori vacuolating cytotoxin to target cells.
Infection and immunity 1998;66(8):3981-4.
1998: M Molinari; C Galli; Marina de Bernard; Nathalie Norais; J M Ruysschaert; Rino Rappuoli; Cesare Montecucco
The acid activation of Helicobacter pylori toxin VacA: structural and membrane binding studies.
Biochemical and biophysical research communications 1998;248(2):334-40.
1998: G Douce; Marzia M Giuliani; V Giannelli; Mariagrazia Pizza; Rino Rappuoli; Gordon Dougan
Mucosal immunogenicity of genetically detoxified derivatives of heat labile toxin from Escherichia coli.
Vaccine 1998;16(11-12):1065-73.
1998: Maria Scarselli; G Esposito; M T De Magistris; M Domenighini; Rino Rappuoli; G Burroni; Andrea Bernini; Neri Niccolai
NMR studies on the structure/function correlations of T-cell-epitope analogs from pertussis toxin.
European journal of biochemistry / FEBS 1998;254(2):313-7.
1998: M Ryan; L McCarthy; Rino Rappuoli; Bernard P Mahon; Kingston H G Mills
Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28.
International immunology 1998;10(5):651-62.
1998: Marzia M Giuliani; Giuseppe Del Giudice; V Giannelli; Gordon Dougan; G Douce; Rino Rappuoli; Mariagrazia Pizza
Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity.
The Journal of experimental medicine 1998;187(7):1123-32.
1998: I Chen; T M Finn; L Yanqing; Q Guoming; Rino Rappuoli; Mariagrazia Pizza
A recombinant live attenuated strain of Vibrio cholerae induces immunity against tetanus toxin and Bordetella pertussis tracheal colonization factor.
Infection and immunity 1998;66(4):1648-53.
1998: A Covacci; Rino Rappuoli
Helicobacter pylori: molecular evolution of a bacterial quasi-species.
Current opinion in microbiology 1998;1(1):96-102.
1998: M Molinari; M Salio; C Galli; Nathalie Norais; Rino Rappuoli; A Lanzavecchia; Cesare Montecucco
Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA.
The Journal of experimental medicine 1998;187(1):135-40.
1998: Emanuele Papini; B Satin; Marina de Bernard; M Molinari; B Aricò; C Galli; J R Telford; Rino Rappuoli; Cesare Montecucco
Action site and cellular effects of cytotoxin VacA produced by Helicobacter pylori.
Folia microbiologica 1998;43(3):279-84.
1998: Rino Rappuoli; C Lange; Stefano Censini; Antonello Covacci
Pathogenicity island mediates Helicobacter pylori interaction with the host.
Folia microbiologica 1998;43(3):275-8.
1998: M Marchetti; M Rossi; V Giannelli; Marzia M Giuliani; Mariagrazia Pizza; Stefano Censini; Antonello Covacci; P Massari; Cristina Pagliaccia; Roberto Manetti; John L Telford; G Douce; Gordon Dougan; Rino Rappuoli; P Ghiara
Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant.
Vaccine 1998;16(1):33-7.
1998: Salvatore Lanzavecchia; Pier Luigi Bellon; Pietro Lupetti; Romano Dallai; Rino Rappuoli; John L Telford
Three-dimensional reconstruction of metal replicas of the Helicobacter pylori vacuolating cytotoxin.
Journal of structural biology 1998;121(1):9-18.
1998: Maria Teresa De Magistris; Mariagrazia Pizza; G Douce; P Ghiara; Gordon Dougan; Rino Rappuoli
Adjuvant effect of non-toxic mutants of E. coli heat-labile enterotoxin following intranasal, oral and intravaginal immunization.
Developments in biological standardization 1998;92():123-6.
1997: P Ghiara; M Rossi; M Marchetti; A Di Tommaso; Carla Vindigni; F Ciampolini; Antonello Covacci; John L Telford; Maria Teresa De Magistris; Mariagrazia Pizza; Rino Rappuoli; Giuseppe Del Giudice
Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection.
Infection and immunity 1997;65(12):4996-5002.
1997: Marina de Bernard; B Arico; Emanuele Papini; R Rizzuto; G Grandi; Rino Rappuoli; Cesare Montecucco
Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosol.
Molecular microbiology 1997;26(4):665-74.
1997: Roberto Manetti; P Massari; M Marchetti; C Magagnoli; Sandra Nuti; Pietro Lupetti; P Ghiara; Rino Rappuoli; John L Telford
Detoxification of the Helicobacter pylori cytotoxin.
Infection and immunity 1997;65(11):4615-9.
1997: Cristina Pagliaccia; Roberto Manetti; Rino Rappuoli
Pertactin antigens extracted from Bordetella pertussis and Bordetella bronchiseptica differ in the isoelectric point.
Archives of microbiology 1997;168(5):437-40.
1997: M Molinari; C Galli; Nathalie Norais; John L Telford; Rino Rappuoli; J P Luzio; Cesare Montecucco
Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers.
The Journal of biological chemistry 1997;272(40):25339-44.
1997: B Satin; Nathalie Norais; J Telford; Rino Rappuoli; M Murgia; Cesare Montecucco; Emanuele Papini
Effect of helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation.
The Journal of biological chemistry 1997;272(40):25022-8.
1997: Gunther Spohn; Dagmar Beier; Rino Rappuoli; Vincenzo Scarlato
Transcriptional analysis of the divergent cagAB genes encoded by the pathogenicity island of Helicobacter pylori.
Molecular microbiology 1997;26(2):361-72.
1997: A Di Tommaso; M Bartalini; Samuele Peppoloni; Audino Podda; Rino Rappuoli; Maria Teresa De Magistris
Acellular pertussis vaccines containing genetically detoxified pertussis toxin induce long-lasting humoral and cellular responses in adults.
Vaccine 1997;15(11):1218-24.
1997: Dagmar Beier; Gunther Spohn; Rino Rappuoli; Vincenzo Scarlato
Identification and characterization of an operon of Helicobacter pylori that is involved in motility and stress adaptation.
Journal of bacteriology 1997;179(15):4676-83.
1997: G Douce; M Fontana; Mariagrazia Pizza; Rino Rappuoli; Gordon Dougan
Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin.
Infection and immunity 1997;65(7):2821-8.
1997: C Wülfing; Rino Rappuoli
Efficient production of heat-labile enterotoxin mutant proteins by overexpression of dsbA in a degP-deficient Escherichia coli strain.
Archives of microbiology 1997;167(5):280-3.
1997: Emanuele Papini; B Satin; C Bucci; Marina de Bernard; John L Telford; Roberto Manetti; Rino Rappuoli; M Zerial; Cesare Montecucco
The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin.
The EMBO journal 1997;16(1):15-24.
1997: V Giannelli; Maria Rita Fontana; Marzia M Giuliani; D Guangcai; Rino Rappuoli; Mariagrazia Pizza
Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop.
Infection and immunity 1997;65(1):331-4.
1996: C Magagnoli; Roberto Manetti; M R Fontana; V Giannelli; Marzia M Giuliani; Rino Rappuoli; Mariagrazia Pizza
Mutations in the A subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin.
Infection and immunity 1996;64(12):5434-8.
1996: Emanuele Papini; Enrico Gottardi; B Satin; Marina de Bernard; P Massari; J Telford; Rino Rappuoli; S B Sato; Cesare Montecucco
The vacuolar ATPase proton pump is present on intracellular vacuoles induced by Helicobacter pylori.
Journal of medical microbiology 1996;45(2):84-9.
1996: Pietro Lupetti; John Edward Heuser; Roberto Manetti; P Massari; Salvatore Lanzavecchia; Pier Luigi Bellon; Romano Dallai; Rino Rappuoli; John L Telford
Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin.
The Journal of cell biology 1996;133(4):801-7.
1996: T Zu; Sophie Goyard; Rino Rappuoli; Vincenzo Scarlato
DNA binding of the Bordetella pertussis H1 homolog alters in vitro DNA flexibility.
Journal of bacteriology 1996;178(10):2982-5.
1996: A Di Tommaso; G Saletti; Mariagrazia Pizza; Rino Rappuoli; Gordon Dougan; Sergio Abrignani; G Douce; Maria Teresa De Magistris
Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant.
Infection and immunity 1996;64(3):974-9.
1996: Pascale Cossart; P Boquet; S Normark; Rino Rappuoli
Cellular microbiology emerging.
Science (New York, N.Y.) 1996;271(5247):315-6.
1996: J Petre; Mariagrazia Pizza; L Nencioni; Antonello Podda; Maria Teresa De Magistris; Rino Rappuoli
The reaction of bacterial toxins with formaldehyde and its use for antigen stabilization.
Developments in biological standardization 1996;87():125-34.
1996: Rino Rappuoli
Acellular pertussis vaccines: a turning point in infant and adolescent vaccination.
Infectious agents and disease 1996;5(1):21-8.
1995: G Moll; Emanuele Papini; Raffaele Colonna; Daniela Burroni; J Telford; Rino Rappuoli; Cesare Montecucco
Lipid interaction of the 37-kDa and 58-kDa fragments of the Helicobacter pylori cytotoxin.
European journal of biochemistry / FEBS 1995;234(3):947-52.
1995: I Cropley; G Douce; Mark Roberts; Steven N Chatfield; Mariagrazia Pizza; I Marsili; Rino Rappuoli; Gordon Dougan
Mucosal and systemic immunogenicity of a recombinant, non-ADP-ribosylating pertussis toxin: effects of formaldehyde treatment.
Vaccine 1995;13(17):1643-8.
1995: Rino Rappuoli; G Douce; Gordon Dougan; Mariagrazia Pizza
Genetic detoxification of bacterial toxins: a new approach to vaccine development.
International archives of allergy and immunology 1995;108(4):327-33.
1995: Roberto Manetti; P Massari; Daniela Burroni; Marina de Bernard; A Marchini; R Olivieri; Emanuele Papini; Cesare Montecucco; Rino Rappuoli; John L Telford
Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies.
Infection and immunity 1995;63(11):4476-80.
1995: Marina de Bernard; Emanuele Papini; V de Filippis; Enrico Gottardi; J Telford; Roberto Manetti; A Fontana; Rino Rappuoli; Cesare Montecucco
Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant.
The Journal of biological chemistry 1995;270(41):23937-40.
1995: A Prugnola; B Aricò; Roberto Manetti; Rino Rappuoli; Vincenzo Scarlato
Response of the bvg regulon of Bordetella pertussis to different temperatures and short-term temperature shifts.
Microbiology (Reading, England) 1995;141 ( Pt 10)():2529-34.
1995: Antonello Podda; G Bona; G Canciani; A M Pistilli; B Contu; R Furlan; T Meloni; D Stramare; Lucina Titone; Rino Rappuoli
Effect of priming with diphtheria and tetanus toxoids combined with whole-cell pertussis vaccine or with acellular pertussis vaccine on the safety and immunogenicity of a booster dose of an acellular pertussis vaccine containing a genetically inactivated pertussis toxin in fifteen- to twenty-one-month-old children. Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine.
The Journal of pediatrics 1995;127(2):238-43.
1995: M R Fontana; Roberto Manetti; V Giannelli; C Magagnoli; A Marchini; R Olivieri; M Domenighini; Rino Rappuoli; Mariagrazia Pizza
Construction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit.
Infection and immunity 1995;63(6):2356-60.
1995: Mark Roberts; A Bacon; Rino Rappuoli; Mariagrazia Pizza; I Cropley; G Douce; Gordon Dougan; M Marinaro; J McGhee; Steven N Chatfield
A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins.
Infection and immunity 1995;63(6):2100-8.
1995: Antonella Bartoloni; Francesco Norelli; C Ceccarini; Rino Rappuoli; paolo costantino
Immunogenicity of meningococcal B polysaccharide conjugated to tetanus toxoid or CRM197 via adipic acid dihydrazide.
Vaccine 1995;13(5):463-70.
1995: M Marchetti; B Aricò; Daniela Burroni; Natale Figura; Rino Rappuoli; P Ghiara
Development of a mouse model of Helicobacter pylori infection that mimics human disease.
Science (New York, N.Y.) 1995;267(5204):1655-8.
1995: A Di Tommaso; Z Xiang; M Bugnoli; P Pileri; Natale Figura; P F Bayeli; Rino Rappuoli; Sergio Abrignani; Maria Teresa De Magistris
Helicobacter pylori-specific CD4+ T-cell clones from peripheral blood and gastric biopsies.
Infection and immunity 1995;63(3):1102-6.
1995: M Domenighini; Mariagrazia Pizza; M G Jobling; R K Holmes; Rino Rappuoli
Identification of errors among database sequence entries and comparison of correct amino acid sequences for the heat-labile enterotoxins of Escherichia coli and Vibrio cholerae.
Molecular microbiology 1995;15(6):1165-7.
1995: Vincenzo Scarlato; B Aricò; Sophie Goyard; S Ricci; Roberto Manetti; A Prugnola; R Manetti; P Polverino-De-Laureto; Agnes Ullmann; Rino Rappuoli
A novel chromatin-forming histone H1 homologue is encoded by a dispensable and growth-regulated gene in Bordetella pertussis.
Molecular microbiology 1995;15(5):871-81.
1995: G Douce; C Turcotte; I Cropley; Mark Roberts; Mariagrazia Pizza; M Domenghini; Rino Rappuoli; Gordon Dougan
Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1644-8.
1995: S Peppoloni; Mariagrazia Pizza; Maria Teresa De Magistris; Antonella Bartoloni; Rino Rappuoli
Acellular pertussis vaccine composed of genetically inactivated pertussis toxin.
Physiological chemistry and physics and medical NMR 1995;27(4):355-61.
1995: Z Xiang; Stefano Censini; P F Bayeli; John L Telford; Natale Figura; Rino Rappuoli; Antonello Covacci
Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin.
Infection and immunity 1995;63(1):94-8.
1994: Roberto Manetti; B Aricò; Rino Rappuoli; Vincenzo Scarlato
Mutations in the linker region of BvgS abolish response to environmental signals for the regulation of the virulence factors in Bordetella pertussis.
Gene 1994;150(1):123-7.
1994: Mariagrazia Pizza; M R Fontana; Marzia M Giuliani; M Domenighini; C Magagnoli; V Giannelli; D Nucci; Wim G J Hol; Roberto Manetti; Rino Rappuoli
A genetically detoxified derivative of heat-labile Escherichia coli enterotoxin induces neutralizing antibodies against the A subunit.
The Journal of experimental medicine 1994;180(6):2147-53.
1994: Rino Rappuoli; Antonello Covacci; P Ghiara; J Telford
Pathogenesis of Helicobacter pylori and perspectives of vaccine development against an emerging pathogen.
Behring Institute Mitteilungen 1994;(95):42-8.
1994: Emanuele Papini; Marina de Bernard; E Milia; M Bugnoli; M Zerial; Rino Rappuoli; Cesare Montecucco
Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9720-4.
1994: Mariagrazia Pizza; M Domenighini; Wim G J Hol; V Giannelli; M R Fontana; Marzia M Giuliani; C Magagnoli; S Peppoloni; Roberto Manetti; Rino Rappuoli
Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis.
Molecular microbiology 1994;14(1):51-60.
1994: M Domenighini; C Magagnoli; Mariagrazia Pizza; Rino Rappuoli
Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins.
Molecular microbiology 1994;14(1):41-50.
1994: Rino Rappuoli; Mariagrazia Pizza; Antonello Podda; Maria Teresa De Magistris; C Ceccarini; L Nencioni
Development of the new acellular recombinant pertussis vaccine.
Archives de l'Institut Pasteur de Tunis 1994;71(3-4):557-63.
1994: A Di Tommaso; Maria Teresa De Magistris; M Bugnoli; I Marsili; Rino Rappuoli; Sergio Abrignani
Formaldehyde treatment of proteins can constrain presentation to T cells by limiting antigen processing.
Infection and immunity 1994;62(5):1830-4.
1993: Emanuele Papini; Marina de Bernard; M Bugnoli; E Milia; Rino Rappuoli; Cesare Montecucco
Cell vacuolization induced by Helicobacter pylori: inhibition by bafilomycins A1, B1, C1 and D.
FEMS microbiology letters 1993;113(2):155-9.
1993: B Aricò; S Nuti; Vincenzo Scarlato; Rino Rappuoli
Adhesion of Bordetella pertussis to eukaryotic cells requires a time-dependent export and maturation of filamentous hemagglutinin.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9204-8.
1993: Vincenzo Scarlato; B Aricò; Rino Rappuoli
DNA topology affects transcriptional regulation of the pertussis toxin gene of Bordetella pertussis in Escherichia coli and in vitro.
Journal of bacteriology 1993;175(15):4764-71.
1993: Antonello Covacci; Rino Rappuoli
Pertussis toxin export requires accessory genes located downstream from the pertussis toxin operon.
Molecular microbiology 1993;8(3):429-34.
1993: Vincenzo Scarlato; B Aricó; M Domenighini; Rino Rappuoli
Environmental regulation of virulence factors in Bordetella species.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(2):99-104.
1993: Emanuele Papini; Rino Rappuoli; Marta Murgia; Cesare Montecucco
Cell penetration of diphtheria toxin. Reduction of the interchain disulfide bridge is the rate-limiting step of translocation in the cytosol.
The Journal of biological chemistry 1993;268(3):1567-74.
1993: Rino Rappuoli; Antonello Podda; F Giovannoni; L Nencioni; M Peragallo; P Francolini
Absence of protective immunity against diphtheria in a large proportion of young adults.
Vaccine 1993;11(5):576-7.
1993: Emanuele Papini; M Bugnoli; Marina de Bernard; N Figura; Rino Rappuoli; Cesare Montecucco
Bafilomycin A1 inhibits Helicobacter pylori-induced vacuolization of HeLa cells.
Molecular microbiology 1993;7(2):323-7.
1993: R Olivieri; M Bugnoli; D Armellini; S Bianciardi; Rino Rappuoli; P F Bayeli; L Abate; E Esposito; L de Gregorio; J Aziz
Growth of Helicobacter pylori in media containing cyclodextrins.
Journal of clinical microbiology 1993;31(1):160-2.
1992: Rino Rappuoli; Mariagrazia Pizza; Antonello Covacci; Antonella Bartoloni; L Nencioni; Antonello Podda; Maria Teresa De Magistris
Recombinant acellular pertussis vaccine--from the laboratory to the clinic: improving the quality of the immune response.
FEMS microbiology immunology 1992;5(4):161-70.
1992: Rino Rappuoli; B Aricó; Vincenzo Scarlato
Thermoregulation and reversible differentiation in Bordetella: a model for pathogenic bacteria.
Molecular microbiology 1992;6(15):2209-11.
1992: Antonello Podda; E C De Luca; Lucina Titone; A M Casadei; Antonio Cascio; S Peppoloni; G Volpini; I Marsili; L Nencioni; Rino Rappuoli
Acellular pertussis vaccine composed of genetically inactivated pertussis toxin: safety and immunogenicity in 12- to 24- and 2- to 4-month-old children.
The Journal of pediatrics 1992;120(5):680-5.
1992: Maria Teresa De Magistris; A Di Tommaso; M Domenighini; Stefano Censini; Aldo Tagliabue; Jorge R Oksenberg; Lawrence Steinman; A K Judd; D O'Sullivan; Rino Rappuoli
Interaction of the pertussis toxin peptide containing residues 30-42 with DR1 and the T-cell receptors of 12 human T-cell clones.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2990-4.
1992: I Marsili; Mariagrazia Pizza; F Giovannoni; G Volpini; M Bartalini; R Olivieri; Rino Rappuoli; L Nencioni
Cellular pertussis vaccine containing a Bordetella pertussis strain that produces a nontoxic pertussis toxin molecule.
Infection and immunity 1992;60(3):1150-5.
1992: Rino Rappuoli; Mariagrazia Pizza; Maria Teresa De Magistris; Antonello Podda; M Bugnoli; Roberto Manetti; L Nencioni
Development and clinical testing of an acellular pertussis vaccine containing genetically detoxified pertussis toxin.
Immunobiology 1992;184(2-3):230-9.
1992: paolo costantino; S Viti; Antonello Podda; M A Velmonte; L Nencioni; Rino Rappuoli
Development and phase 1 clinical testing of a conjugate vaccine against meningococcus A and C.
Vaccine 1992;10(10):691-8.
1992: A Sansoni; Rino Rappuoli; S Viti; paolo costantino; O Fanti; Carla Cellesi
Immunity to Haemophilus influenzae type b on sample population from central Italy.
Vaccine 1992;10(9):627-30.
1992: Rino Rappuoli; Antonello Podda; Mariagrazia Pizza; Antonello Covacci; Antonella Bartoloni; Maria Teresa De Magistris; L Nencioni
Progress towards the development of new vaccines against whooping cough.
Vaccine 1992;10(14):1027-32.
1991: L Nencioni; Mariagrazia Pizza; G Volpini; Maria Teresa De Magistris; F Giovannoni; Rino Rappuoli
Properties of the B oligomer of pertussis toxin.
Infection and immunity 1991;59(12):4732-4.
1991: Vincenzo Scarlato; B Aricò; A Prugnola; Rino Rappuoli
Sequential activation and environmental regulation of virulence genes in Bordetella pertussis.
The EMBO journal 1991;10(12):3971-5.
1991: Vincenzo Scarlato; Rino Rappuoli
Differential response of the bvg virulence regulon of Bordetella pertussis to MgSO4 modulation.
Journal of bacteriology 1991;173(22):7401-4.
1991: Vincenzo Scarlato; A Prugnola; B Aricò; Rino Rappuoli
The bvg-dependent promoters show similar behaviour in different Bordetella species and share sequence homologies.
Molecular microbiology 1991;5(10):2493-8.
1991: B Aricò; Vincenzo Scarlato; D M Monack; S Falkow; Rino Rappuoli
Structural and genetic analysis of the bvg locus in Bordetella species.
Molecular microbiology 1991;5(10):2481-91.
1991: Antonello Podda; L Nencioni; I Marsili; S Peppoloni; G Volpini; D Donati; A Di Tommaso; Maria Teresa De Magistris; Rino Rappuoli
Phase I clinical trial of an acellular pertussis vaccine composed of genetically detoxified pertussis toxin combined with FHA and 69 kDa.
Vaccine 1991;9(10):741-5.
1991: S Peppoloni; L Nencioni; A Di Tommaso; Aldo Tagliabue; P Parronchi; S Romagnani; Rino Rappuoli; Maria Teresa De Magistris
Lymphokine secretion and cytotoxic activity of human CD4+ T-cell clones against Bordetella pertussis.
Infection and immunity 1991;59(10):3768-73.
1991: A Di Tommaso; M Domenighini; M Bugnoli; Aldo Tagliabue; Rino Rappuoli; Maria Teresa De Magistris
Identification of subregions of Bordetella pertussis filamentous hemagglutinin that stimulate human T-cell responses.
Infection and immunity 1991;59(9):3313-5.
1991: Rino Rappuoli; Mariagrazia Pizza; Antonello Podda; Maria Teresa De Magistris; L Nencioni
Towards third-generation whooping cough vaccines.
Trends in biotechnology 1991;9(7):232-8.
1991: Mariagrazia Pizza; M Bugnoli; Piero Pucci; R Siciliano; G Marino; Rino Rappuoli
Further analysis of the sequence of the S1 subunit of pertussis toxin.
Infection and immunity 1991;59(3):1177-9.
1991: Antonello Podda; Nicoletta Vescia; D Donati; I Marsili; G Volpini; L Nencioni; I Mastroeni; Rino Rappuoli; G M Fara
[A phase-I clinical trial of a new antitetanus/antidiphtheria vaccine for adults].
Annali di igiene : medicina preventiva e di comunità 1991;3(2):79-84.
1991: Emanuele Papini; A Santucci; Giampietro Schiavo; M Domenighini; P Neri; Rino Rappuoli; Cesare Montecucco
Tyrosine 65 is photolabeled by 8-azidoadenine and 8-azidoadenosine at the NAD binding site of diphtheria toxin.
The Journal of biological chemistry 1991;266(4):2494-8.
1991: L Nencioni; G Volpini; S Peppoloni; M Bugnoli; T De Magistris; I Marsili; Rino Rappuoli
Properties of pertussis toxin mutant PT-9K/129G after formaldehyde treatment.
Infection and immunity 1991;59(2):625-30.
1991: E Padovan; Emanuele Papini; Rino Rappuoli; Cesare Montecucco
Determination of diphtheria toxin neutralizing antibody titers with a cell protein synthesis inhibition assay.
Medical microbiology and immunology 1991;180(1):29-35.
1991: M Domenighini; C Montecucco; W C Ripka; Rino Rappuoli
Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding.
Molecular microbiology 1991;5(1):23-31.
1991: L Nencioni; Mariagrazia Pizza; G Volpini; Antonello Podda; Rino Rappuoli
Genetic approaches to a vaccine for pertussis.
Advances in experimental medicine and biology 1991;303():119-27.
1990: Vincenzo Scarlato; A Prugnola; B Aricó; Rino Rappuoli
Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):10067.
1990: Mariagrazia Pizza; M Bugnoli; Roberto Manetti; Antonello Covacci; Rino Rappuoli
The subunit S1 is important for pertussis toxin secretion.
The Journal of biological chemistry 1990;265(29):17759-63.
1990: Vincenzo Scarlato; A Prugnola; B Aricó; Rino Rappuoli
Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6753-7.
1990: M Domenighini; David A Relman; C Capiau; S Falkow; A Prugnola; Vincenzo Scarlato; Rino Rappuoli
Genetic characterization of Bordetella pertussis filamentous haemagglutinin: a protein processed from an unusually large precursor.
Molecular microbiology 1990;4(5):787-800.
1990: Emanuele Papini; Giampietro Schiavo; Rino Rappuoli; Cesare Montecucco
Histidine-21 is involved in diphtheria toxin NAD+ binding.
Toxicon : official journal of the International Society on Toxinology 1990;28(6):631-5.
1989: R Gross; B Aricò; Rino Rappuoli
Families of bacterial signal-transducing proteins.
Molecular microbiology 1989;3(11):1661-7.
1989: Antonella Bartoloni; Mariagrazia Pizza; A Tagliabue; Rino Rappuoli
Engineering bacterial toxins for the development of a new vaccine against whooping cough.
Pharmacological research : the official journal of the Italian Pharmacological Society 1989;21 Suppl 2():19-25.
1989: B Aricó; J F Miller; C Roy; Scott Stibitz; D Monack; S Falkow; R Gross; Rino Rappuoli
Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6671-5.
1989: Emanuele Papini; Giampietro Schiavo; D Sandoná; Rino Rappuoli; Cesare Montecucco
Histidine 21 is at the NAD+ binding site of diphtheria toxin.
The Journal of biological chemistry 1989;264(21):12385-8.
1989: R Gross; Rino Rappuoli
Pertussis toxin promoter sequences involved in modulation.
Journal of bacteriology 1989;171(7):4026-30.
1989: R Presentini; F Perin; G Ancilli; D Nucci; Antonella Bartoloni; Rino Rappuoli; G Antoni
Studies of the antigenic structure of two cross-reacting proteins, pertussis and cholera toxins, using synthetic peptides.
Molecular immunology 1989;26(1):95-100.
1989: R Gross; B Aricò; Rino Rappuoli
Genetics of pertussis toxin.
Molecular microbiology 1989;3(1):119-24.
1988: Emanuele Papini; D Sandoná; Rino Rappuoli; Cesare Montecucco
On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells.
The EMBO journal 1988;7(11):3353-9.
1988: Mariagrazia Pizza; Antonella Bartoloni; A Prugnola; S Silvestri; Rino Rappuoli
Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7521-5.
1988: Maria Teresa De Magistris; M Romano; Sandra Nuti; Rino Rappuoli; Aldo Tagliabue
Dissecting human T cell responses against Bordetella species.
The Journal of experimental medicine 1988;168(4):1351-62.
1988: R Gross; Rino Rappuoli
Positive regulation of pertussis toxin expression.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):3913-7.
1988: Rino Rappuoli; M Perugini; E Falsen
Molecular epidemiology of the 1984-1986 outbreak of diphtheria in Sweden.
The New England journal of medicine 1988;318(1):12-4.
1988: A Tagliabue; Maria Teresa De Magistris; Rino Rappuoli
Human T-cell immunity against Bordetella pertussis analyzed at clonal level.
The Tokai journal of experimental and clinical medicine 1988;13 Suppl():253-7.
1988: Antonella Bartoloni; Mariagrazia Pizza; R Gross; M Perugini; B Arico; M Domenighini; Rino Rappuoli
Engineering bacterial toxin for the development of new vaccine against pertussis.
The Tokai journal of experimental and clinical medicine 1988;13 Suppl():217-22.
1987: Emanuele Papini; Giampietro Schiavo; M Tomasi; M Colombatti; Rino Rappuoli; Cesare Montecucco
Lipid interaction of diphtheria toxin and mutants with altered fragment B. 2. Hydrophobic photolabelling and cell intoxication.
European journal of biochemistry / FEBS 1987;169(3):637-44.
1987: Emanuele Papini; Raffaele Colonna; Federico Cusinato; Cesare Montecucco; M Tomasi; Rino Rappuoli
Lipid interaction of diphtheria toxin and mutants with altered fragment B. 1. Liposome aggregation and fusion.
European journal of biochemistry / FEBS 1987;169(3):629-35.
1987: B Aricò; R Gross; J Smida; Rino Rappuoli
Evolutionary relationships in the genus Bordetella.
Molecular microbiology 1987;1(3):301-8.
1987: M Bigio; R Rossi; D Nucci; G Antoni; Rino Rappuoli; G Ratti
Conformational changes in diphtheria toxoids. Analysis with monoclonal antibodies.
FEBS letters 1987;218(2):271-6.
1987: Emanuele Papini; Raffaele Colonna; Giampietro Schiavo; Federico Cusinato; M Tomasi; Rino Rappuoli; Cesare Montecucco
Diphtheria toxin and its mutant crm 197 differ in their interaction with lipids.
FEBS letters 1987;215(1):73-8.
1987: A Nicosia; Antonella Bartoloni; M Perugini; Rino Rappuoli
Expression and immunological properties of the five subunits of pertussis toxin.
Infection and immunity 1987;55(4):963-7.
1987: Rino Rappuoli; M Perugini; G Ratti
DNA element of Corynebacterium diphtheriae with properties of an insertion sequence and usefulness for epidemiological studies.
Journal of bacteriology 1987;169(1):308-12.
1986: A Nicosia; M Perugini; C Franzini; M C Casagli; M G Borri; G Antoni; M Almoni; Paolo Neri; G Ratti; Rino Rappuoli
Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(13):4631-5.
1986: M Bigio; R Rossi; M G Borri; Rino Rappuoli; Antonella Bartoloni; D Nucci; M Bartalini; G Antoni
Production and characterization of monoclonal antibodies (Mabs) specifically reactive with the different subunits of toxin from "Bordetella pertussis".
Annali Sclavo. Collana monografica 1986;3(1-2):277-81.
1986: R Presentini; F Perin; G Ancilli; Rino Rappuoli; Antonella Bartoloni; Luisa Lozzi; Paolo Neri; G Antoni
Antigenic recognition of pertussis and cholera toxin by the same antipeptide antibodies.
Annali Sclavo. Collana monografica 1986;3(1-2):283-8.
1986: Rino Rappuoli; A Nicosia; Antonella Bartoloni; B Aricò; M Perugini
A recombinant DNA approach to the pertussis vaccine.
Annali Sclavo. Collana monografica 1986;3(1-2):183-9.
1985: Rino Rappuoli; G Ratti; M Perugini; J R Murphy
Detection and physical map of a omega tox+-related defective prophage in Corynebacterium diphtheriae Belfanti 1030(-)tox-.
Journal of virology 1985;54(1):194-8.