Rino Rappuoli

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Santos George F; Giuliani Marzia; Santini Laura; Adu-Bobie Jeanette; Pizza Mariagrazia; Rappuoli Rino; Wacknov William; Donnelly John
Investigation on the effect of immune selection on resistance to bactericidal antibodies to group B meningococci in vitro.
Seib Kate L; Dougan Gordon; Rappuoli Rino
The key role of genomics in modern vaccine and drug design for emerging infectious diseases.
Rappuoli Rino; Del Giudice Giuseppe; Nabel Gary J; Osterhaus Albert D M E; Robinson Robin; Salisbury David; Stöhr Klaus; Treanor John J
Public health. Rethinking influenza.

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All Publications

2009: Santos George F; Giuliani Marzia; Santini Laura; Adu-Bobie Jeanette; Pizza Mariagrazia; Rappuoli Rino; Wacknov William; Donnelly John
Investigation on the effect of immune selection on resistance to bactericidal antibodies to group B meningococci in vitro.
Clinical and vaccine immunology : CVI 2009;16(11):1693-5.
2009: Seib Kate L; Dougan Gordon; Rappuoli Rino
The key role of genomics in modern vaccine and drug design for emerging infectious diseases.
PLoS genetics 2009;5(10):e1000612.
2009: Rappuoli Rino; Del Giudice Giuseppe; Nabel Gary J; Osterhaus Albert D M E; Robinson Robin; Salisbury David; Stöhr Klaus; Treanor John J
Public health. Rethinking influenza.
Science (New York, N.Y.) 2009;326(5949):50.
2009: Alberini Isabella; Del Tordello Elena; Fasolo Alba; Temperton Nigel J; Galli Grazia; Gentile Chiara; Montomoli Emanuele; Hilbert Anne K; Banzhoff Angelika; Del Giudice Giuseppe; Donnelly John J; Rappuoli Rino; Capecchi Barbara
Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses.
Vaccine 2009;27(43):5998-6003.
2009: Rinaudo C Daniela; Telford John L; Rappuoli Rino; Seib Kate L
Vaccinology in the genome era.
The Journal of clinical investigation 2009;119(9):2515-25.
2009: Bröker Michael; Dull Peter M; Rappuoli Rino; Costantino Paolo
Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages.
Vaccine 2009;27(41):5574-80.
2009: Castellino Flora; Galli Grazia; Del Giudice Giuseppe; Rappuoli Rino
Generating memory with vaccination.
European journal of immunology 2009;39(8):2100-5.
2009: Del Giudice Giuseppe; Malfertheiner Peter; Rappuoli Rino
Development of vaccines against Helicobacter pylori.
Expert review of vaccines 2009;8(8):1037-49.
2009: Nasso Maria; Fedele Giorgio; Spensieri Fabiana; Palazzo Raffaella; Costantino Paolo; Rappuoli Rino; Ausiello Clara Maria
Genetically detoxified pertussis toxin induces Th1/Th17 immune response through MAPKs and IL-10-dependent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1892-9.
2009: Gianfaldoni Claudia; Maccari Silvia; Pancotto Laura; Rossi Giacomo; Hilleringmann Markus; Pansegrau Werner; Sinisi Antonia; Moschioni Monica; Masignani Vega; Rappuoli Rino; Del Giudice Giuseppe; Ruggiero Paolo
Sortase A confers protection against Streptococcus pneumoniae in mice.
Infection and immunity 2009;77(7):2957-61.
2009: Serruto Davide; Spadafina Tiziana; Scarselli Maria; Bambini Stefania; Comanducci Maurizio; Höhle Sonja; Kilian Mogens; Veiga Esteban; Cossart Pascale; Oggioni Marco R; Savino Silvana; Ferlenghi Ilaria; Taddei Anna Rita; Rappuoli Rino; Pizza Mariagrazia; Masignani Vega; Aricò Beatrice
HadA is an atypical new multifunctional trimeric coiled-coil adhesin of Haemophilus influenzae biogroup aegyptius, which promotes entry into host cells.
Cellular microbiology 2009;11(7):1044-63.
2009: Copley Shelley; Rappuoli Rino
Genomics of ecology and industrial microbiology.
Current opinion in microbiology 2009;12(3):221-2.
2009: Bambini Stefania; Muzzi Alessandro; Olcen Per; Rappuoli Rino; Pizza Mariagrazia; Comanducci Maurizio
Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcus.
Vaccine 2009;27(21):2794-803.
2009: Medaglini Donata; Olesen Ole F; Rappuoli Rino
The European effort towards the development of mucosal vaccines for poverty-related diseases.
Vaccine 2009;27(20):2641-8.
2009: Cantini Francesca; Veggi Daniele; Dragonetti Sara; Savino Silvana; Scarselli Maria; Romagnoli Giacomo; Pizza Mariagrazia; Banci Lucia; Rappuoli Rino
Solution structure of the factor H-binding protein, a survival factor and protective antigen of Neisseria meningitidis.
The Journal of biological chemistry 2009;284(14):9022-6.
2009: Galli Grazia; Medini Duccio; Borgogni Erica; Zedda Luisanna; Bardelli Monia; Malzone Carmine; Nuti Sandra; Tavarini Simona; Sammicheli Chiara; Hilbert Anne K; Brauer Volker; Banzhoff Angelika; Rappuoli Rino; Del Giudice Giuseppe; Castellino Flora
Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3877-82.
2009: Jacobsson Susanne; Hedberg Sara Thulin; Mölling Paula; Unemo Magnus; Comanducci Maurizio; Rappuoli Rino; Olcén Per
Prevalence and sequence variations of the genes encoding the five antigens included in the novel 5CVMB vaccine covering group B meningococcal disease.
Vaccine 2009;27(10):1579-84.
2009: Bambini Stefania; Rappuoli Rino
The use of genomics in microbial vaccine development.
Drug discovery today 2009;14(5-6):252-60.
2009: Tamayo Esther; Postigo Jorge; Del Giudice Giuseppe; Rappuoli Rino; Benito Adalberto; Yagita Hideo; Merino Ramón; Merino Jesús
Involvement of the intrinsic and extrinsic cell-death pathways in the induction of apoptosis of mature lymphocytes by the Escherichia coli heat-labile enterotoxin.
European journal of immunology 2009;39(2):439-46.
2009: Scarselli Maria; Cantini Francesca; Santini Laura; Veggi Daniele; Dragonetti Sara; Donati Claudio; Savino Silvana; Giuliani Marzia M; Comanducci Maurizio; Di Marcello Federica; Romagnoli Giacomo; Pizza Mariagrazia; Banci Lucia; Rappuoli Rino
Epitope mapping of a bactericidal monoclonal antibody against the factor H binding protein of Neisseria meningitidis.
Journal of molecular biology 2009;386(1):97-108.
2009: Lewis David J M; Huo Zhiming; Barnett Susan; Kromann Ingrid; Giemza Rafaela; Galiza Eva; Woodrow Maria; Thierry-Carstensen Birgit; Andersen Peter; Novicki Deborah; Del Giudice Giuseppe; Rappuoli Rino
Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin.
PloS one 2009;4(9):e6999.
2008: Pizza Mariagrazia; Donnelly John; Rappuoli Rino
Factor H-binding protein, a unique meningococcal vaccine antigen.
Vaccine 2008;26 Suppl 8():I46-8.
2008: Finco Oretta; Rappuoli Rino
Rediscovering complement, the first barrier of innate immunity.
Vaccine 2008;26 Suppl 8():I1-2.
2008: Valiante Nicholas; De Gregorio Ennio; Rappuoli Rino
Toll-free immunity?
Nature medicine 2008;14(12):1318-9.
2008: Dormitzer Philip R; Ulmer Jeffrey B; Rappuoli Rino
Structure-based antigen design: a strategy for next generation vaccines.
Trends in biotechnology 2008;26(12):659-67.
2008: Tagliabue Aldo; Rappuoli Rino
Vaccine adjuvants: the dream becomes real.
Human vaccines 2008;4(5):347-9.
2008: Malfertheiner Peter; Schultze Viola; Rosenkranz Bernd; Kaufmann Stefan H E; Ulrichs Timo; Novicki Deborah; Norelli Francesco; Contorni Mario; Peppoloni Samuele; Berti Duccio; Tornese Daniela; Ganju Jitendra; Palla Emanuela; Rappuoli Rino; Scharschmidt Bruce F; Del Giudice Giuseppe
Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: a phase I study.
Gastroenterology 2008;135(3):787-95.
2008: De Gregorio Ennio; Tritto Elaine; Rappuoli Rino
Alum adjuvanticity: unraveling a century old mystery.
European journal of immunology 2008;38(8):2068-71.
2008: Bagnoli Fabio; Moschioni Monica; Donati Claudio; Dimitrovska Valentina; Ferlenghi Ilaria; Facciotti Claudia; Muzzi Alessandro; Giusti Fabiola; Emolo Carla; Sinisi Antonella; Hilleringmann Markus; Pansegrau Werner; Censini Stefano; Rappuoli Rino; Covacci Antonello; Masignani Vega; Barocchi Michele A
A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells.
Journal of bacteriology 2008;190(15):5480-92.
2008: Mosca F; Tritto E; Muzzi A; Monaci E; Bagnoli F; Iavarone C; O'Hagan D; Rappuoli R; De Gregorio E
Molecular and cellular signatures of human vaccine adjuvants.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(30):10501-6.
2008: Medini Duccio; Serruto Davide; Parkhill Julian; Relman David A; Donati Claudio; Moxon Richard; Falkow Stanley; Rappuoli Rino
Microbiology in the post-genomic era.
Nature reviews. Microbiology 2008;6(6):419-30.
2008: Bertini Ivano; Garattini Silvio; Rappuoli Rino
Italy must invest more in science and technology.
Nature 2008;452(7188):685.
2008: Bardotti Angela; Averani Giovanni; Berti Francesco; Berti Stefania; Carinci Valeria; D'Ascenzi Sandro; Fabbri Barbara; Giannini Sara; Giannozzi Aldo; Magagnoli Claudia; Proietti Daniela; Norelli Francesco; Rappuoli Rino; Ricci Stefano; Costantino Paolo
Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases.
Vaccine 2008;26(18):2284-96.
2008: Stickings Paul; Peyre Marisa; Coombes Laura; Muller Sylviane; Rappuoli Rino; Del Giudice Giuseppe; Partidos Charalambos D; Sesardic Dorothea
Transcutaneous immunization with cross-reacting material CRM(197) of diphtheria toxin boosts functional antibody levels in mice primed parenterally with adsorbed diphtheria toxoid vaccine.
Infection and immunity 2008;76(4):1766-73.
2008: Hilleringmann Markus; Giusti Fabiola; Baudner Barbara C; Masignani Vega; Covacci Antonello; Rappuoli Rino; Barocchi Michèle A; Ferlenghi Ilaria
Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A.
PLoS pathogens 2008;4(3):e1000026.
2008: Moschioni Monica; Donati Claudio; Muzzi Alessandro; Masignani Vega; Censini Stefano; Hanage William P; Bishop Cynthia J; Reis Joice Neves; Normark Staffan; Henriques-Normark Birgitta; Covacci Antonello; Rappuoli Rino; Barocchi Michèle A
Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related.
The Journal of infectious diseases 2008;197(6):888-96.
2008: Wack Andreas; Baudner Barbara C; Hilbert Anne K; Manini Ilaria; Nuti Sandra; Tavarini Simona; Scheffczik Hanno; Ugozzoli Mildred; Singh Manmohan; Kazzaz Jina; Montomoli Emanuele; Del Giudice Giuseppe; Rappuoli Rino; O'Hagan Derek T
Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice.
Vaccine 2008;26(4):552-61.
2008: Saul Allan; Rappuoli Rino
The Novartis Vaccines Institute for Global Health: a new initiative for developing vaccines for neglected diseases in developing countries.
Journal of infection in developing countries 2008;2(2):154-5.
2008: Muzzi Alessandro; Moschioni Monica; Covacci Antonello; Rappuoli Rino; Donati Claudio
Pilus operon evolution in Streptococcus pneumoniae is driven by positive selection and recombination.
PloS one 2008;3(11):e3660.
2007: Rappuoli Rino
Bridging the knowledge gaps in vaccine design.
Nature biotechnology 2007;25(12):1361-6.
2007: Tritto Elaine; Muzzi Alessandro; Pesce Isabella; Monaci Elisabetta; Nuti Sandra; Galli Grazia; Wack Andreas; Rappuoli Rino; Hussell Tracy; De Gregorio Ennio
The acquired immune response to the mucosal adjuvant LTK63 imprints the mouse lung with a protective signature.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5346-57.
2007: Nelson A L; Ries J; Bagnoli F; Dahlberg S; Fälker S; Rounioja S; Tschöp J; Morfeldt E; Ferlenghi I; Hilleringmann M; Holden D W; Rappuoli R; Normark S; Barocchi M A; Henriques-Normark B
RrgA is a pilus-associated adhesin in Streptococcus pneumoniae.
Molecular microbiology 2007;66(2):329-40.
2007: Rappuoli Rino
An audience with... Rino Rappuoli.
Nature reviews. Drug discovery 2007;6(9):694.
2007: Balducci Enrico; Micossi Luigi G; Soldaini Elisabetta; Rappuoli Rino
Expression and selective up-regulation of toxin-related mono ADP-ribosyltransferases by pathogen-associated molecular patterns in alveolar epithelial cells.
FEBS letters 2007;581(22):4199-204.
2007: Sjöström K; Blomberg C; Fernebro J; Dagerhamn J; Morfeldt E; Barocchi M A; Browall S; Moschioni M; Andersson M; Henriques F; Albiger B; Rappuoli Rino; Normark S; Henriques-Normark B
Clonal success of piliated penicillin nonsusceptible pneumococci.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12907-12.
2007: Serino Laura; Nesta Barbara; Leuzzi Rosanna; Fontana Maria Rita; Monaci Elisabetta; Mocca Brian T; Cartocci Elena; Masignani Vega; Jerse Ann E; Rappuoli Rino; Pizza Mariagrazia
Identification of a new OmpA-like protein in Neisseria gonorrhoeae involved in the binding to human epithelial cells and in vivo colonization.
Molecular microbiology 2007;64(5):1391-403.
2007: Muzzi Alessandro; Masignani Vega; Rappuoli Rino
The pan-genome: towards a knowledge-based discovery of novel targets for vaccines and antibacterials.
Drug discovery today 2007;12(11-12):429-39.
2007: Barocchi Michèle Anne; Censini Stefano; Rappuoli Rino
Vaccines in the era of genomics: the pneumococcal challenge.
Vaccine 2007;25(16):2963-73.
2007: Galli Grazia; Pittoni Paola; Tonti Elena; Malzone Carmine; Uematsu Yasushi; Tortoli Marco; Maione Domenico; Volpini Gianfranco; Finco Oretta; Nuti Sandra; Tavarini Simona; Dellabona Paolo; Rappuoli Rino; Casorati Giulia; Abrignani Sergio
Invariant NKT cells sustain specific B cell responses and memory.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3984-9.
2007: Dotta Francesco; Censini Stefano; van Halteren Astrid G S; Marselli Lorella; Masini Matilde; Dionisi Sabrina; Mosca Franco; Boggi Ugo; Muda Andrea Onetti; Prato Stefano Del; Elliott John F; Covacci Antonello; Rappuoli Rino; Roep Bart O; Marchetti Piero
Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5115-20.
2007: Gianfaldoni Claudia; Censini Stefano; Hilleringmann Markus; Moschioni Monica; Facciotti Claudia; Pansegrau Werner; Masignani Vega; Covacci Antonello; Rappuoli Rino; Barocchi Michèle Anne; Ruggiero Paolo
Streptococcus pneumoniae pilus subunits protect mice against lethal challenge.
Infection and immunity 2007;75(2):1059-62.
2006: Hotopp Julie C Dunning; Grifantini Renata; Kumar Nikhil; Tzeng Yih Ling; Fouts Derrick; Frigimelica Elisabetta; Draghi Monia; Giuliani Marzia Monica; Rappuoli Rino; Stephens David S; Grandi Guido; Tettelin Hervé
Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes.
Microbiology (Reading, England) 2006;152(Pt 12):3733-49.
2006: Johri Atul Kumar; Paoletti Lawrence C; Glaser Philippe; Dua Meenakshi; Sharma Puja Kumari; Grandi Guido; Rappuoli Rino
Group B Streptococcus: global incidence and vaccine development.
Nature reviews. Microbiology 2006;4(12):932-42.
2006: Ulmer Jeffrey B; Valley Ulrich; Rappuoli Rino
Vaccine manufacturing: challenges and solutions.
Nature biotechnology 2006;24(11):1377-83.
2006: Dietrich Jes; Andersen Claire; Rappuoli Rino; Doherty T Mark; Jensen Charlotte Green; Andersen Peter
Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6353-60.
2006: Mora Marirosa; Donati Claudio; Medini Duccio; Covacci Antonello; Rappuoli Rino
Microbial genomes and vaccine design: refinements to the classical reverse vaccinology approach.
Current opinion in microbiology 2006;9(5):532-6.
2006: Del Giudice Giuseppe; Fragapane Elena; Bugarini Roberto; Hora Maninder; Henriksson Thomas; Palla Emanuela; O'hagan Derek; Donnelly John; Rappuoli Rino; Podda Audino
Vaccines with the MF59 adjuvant do not stimulate antibody responses against squalene.
Clinical and vaccine immunology : CVI 2006;13(9):1010-3.
2006: Peiser Leanne; Makepeace Katherine; Plüddemann Annette; Savino Silvana; Wright J Claire; Pizza Mariagrazia; Rappuoli Rino; Moxon E Richard; Gordon Siamon
Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay.
Infection and immunity 2006;74(9):5191-9.
2006: Bagnoli Fabio; Rappuoli Rino
Targeting infectious diseases in the genomics era.
Current opinion in investigational drugs (London, England : 2000) 2006;7(8):695-8.
2006: Scarselli Maria; Serruto Davide; Montanari Paolo; Capecchi Barbara; Adu-Bobie Jeannette; Veggi Daniele; Rappuoli Rino; Pizza Mariagrazia; Aricò Beatrice
Neisseria meningitidis NhhA is a multifunctional trimeric autotransporter adhesin.
Molecular microbiology 2006;61(3):631-44.
2006: Giuliani Marzia M; Adu-Bobie Jeannette; Comanducci Maurizio; Aricò Beatrice; Savino Silvana; Santini Laura; Brunelli Brunella; Bambini Stefania; Biolchi Alessia; Capecchi Barbara; Cartocci Elena; Ciucchi Laura; Di Marcello Federica; Ferlicca Francesca; Galli Barbara; Luzzi Enrico; Masignani Vega; Serruto Davide; Veggi Daniele; Contorni Mario; Morandi Maurizio; Bartalesi Alessandro; Cinotti Vanda; Mannucci Donatella; Titta Francesca; Ovidi Elisa; Welsch Jo Anne; Granoff Dan; Rappuoli Rino; Pizza Mariagrazia
A universal vaccine for serogroup B meningococcus.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10834-9.
2006: Danielli Alberto; Roncarati Davide; Delany Isabel; Chiarini Valentina; Rappuoli Rino; Scarlato Vincenzo
In vivo dissection of the Helicobacter pylori Fur regulatory circuit by genome-wide location analysis.
Journal of bacteriology 2006;188(13):4654-62.
2006: Telford John L; Barocchi Michèle A; Margarit Immaculada; Rappuoli Rino; Grandi Guido
Pili in gram-positive pathogens.
Nature reviews. Microbiology 2006;4(7):509-19.
2006: Serruto Davide; Rappuoli Rino
Post-genomic vaccine development.
FEBS letters 2006;580(12):2985-92.
2006: Delany Isabel; Grifantini Renata; Bartolini Erika; Rappuoli Rino; Scarlato Vincenzo
Effect of Neisseria meningitidis fur mutations on global control of gene transcription.
Journal of bacteriology 2006;188(7):2483-92.
2006: O'Hagan Derek T; Rappuoli Rino
Novel approaches to pediatric vaccine delivery.
Advanced drug delivery reviews 2006;58(1):29-51.
2006: Del Giudice Giuseppe; Hilbert Anne Katrin; Bugarini Roberto; Minutello Ada; Popova Olga; Toneatto Daniela; Schoendorf Ines; Borkowski Astrid; Rappuoli Rino; Podda Audino
An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine.
Vaccine 2006;24(16):3063-5.
2006: Bakke H; Samdal H H; Holst J; Oftung F; Haugen I L; Kristoffersen A-C; Haugan A; Janakova L; Korsvold G E; Krogh G; Andersen E A S; Djupesland P; Holand T; Rappuoli R; Haneberg B
Oral spray immunization may be an alternative to intranasal vaccine delivery to induce systemic antibodies but not nasal mucosal or cellular immunity.
Scandinavian journal of immunology 2006;63(3):223-31.
2006: Cantini Francesca; Savino Silvana; Scarselli Maria; Masignani Vega; Pizza Mariagrazia; Romagnoli Giacomo; Swennen Erwin; Veggi Daniele; Banci Lucia; Rappuoli Rino
Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis.
The Journal of biological chemistry 2006;281(11):7220-7.
2006: Jacobsson Susanne; Thulin Sara; Mölling Paula; Unemo Magnus; Comanducci Maurizio; Rappuoli Rino; Olcén Per
Sequence constancies and variations in genes encoding three new meningococcal vaccine candidate antigens.
Vaccine 2006;24(12):2161-8.
2006: Barocchi M A; Ries J; Zogaj X; Hemsley C; Albiger B; Kanth A; Dahlberg S; Fernebro J; Moschioni M; Masignani V; Hultenby K; Taddei A R; Beiter K; Wartha F; von Euler A; Covacci A; Holden D W; Normark S; Rappuoli R; Henriques-Normark B
A pneumococcal pilus influences virulence and host inflammatory responses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2857-62.
2006: Pal Sukumar; Peterson Ellena M; Rappuoli Rino; Ratti Giulio; de la Maza Luis M
Immunization with the Chlamydia trachomatis major outer membrane protein, using adjuvants developed for human vaccines, can induce partial protection in a mouse model against a genital challenge.
Vaccine 2006;24(6):766-75.
2006: Soriani Marco; Santi Isabella; Taddei Annarita; Rappuoli Rino; Grandi Guido; Telford John L
Group B Streptococcus crosses human epithelial cells by a paracellular route.
The Journal of infectious diseases 2006;193(2):241-50.
2005: Huo Zhiming; Sinha Ruchi; McNeela Edel A; Borrow Ray; Giemza Rafaela; Cosgrove Catherine; Heath Paul T; Mills Kingston H G; Rappuoli Rino; Griffin George E; Lewis David J M
Induction of protective serum meningococcal bactericidal and diphtheria-neutralizing antibodies and mucosal immunoglobulin A in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with chitosan.
Infection and immunity 2005;73(12):8256-65.
2005: Tamayo Esther; Merino Ramón; González-Rojas Jovanna; Marquina Regina; Santiuste Inés; Amado José Antonio; Rappuoli Rino; Del Giudice Giuseppe; Merino Jesús
The Escherichia coli heat-labile enterotoxin induces apoptosis of immature lymphocytes in vivo via a glucocorticoid-dependent pathway.
European journal of immunology 2005;35(12):3505-15.
2005: Daems Rudi; Del Giudice Giuseppe; Rappuoli Rino
Anticipating crisis: towards a pandemic flu vaccination strategy through alignment of public health and industrial policy.
Vaccine 2005;23(50):5732-42.
2005: Medini Duccio; Donati Claudio; Tettelin Hervé; Masignani Vega; Rappuoli Rino
The microbial pan-genome.
Current opinion in genetics & development 2005;15(6):589-94.
2005: Stadler K; Rappuoli R
SARS: understanding the virus and development of rational therapy.
Current molecular medicine 2005;5(7):677-97.
2005: Barnett Susan W; Srivastava Indresh K; Ulmer Jeffrey B; Donnelly John J; Rappuoli Rino
Development of V2-deleted trimeric envelope vaccine candidates from human immunodeficiency virus type 1 (HIV-1) subtypes B and C.
Microbes and infection / Institut Pasteur 2005;7(14):1386-91.
2005: Delany Isabel; Ieva Raffaele; Soragni Alice; Hilleringmann Markus; Rappuoli Rino; Scarlato Vincenzo
In vitro analysis of protein-operator interactions of the NikR and fur metal-responsive regulators of coregulated genes in Helicobacter pylori.
Journal of bacteriology 2005;187(22):7703-15.
2005: Kong Wing-pui; Xu Ling; Stadler Konrad; Ulmer Jeffrey B; Abrignani Sergio; Rappuoli Rino; Nabel Gary J
Modulation of the immune response to the severe acute respiratory syndrome spike glycoprotein by gene-based and inactivated virus immunization.
Journal of virology 2005;79(22):13915-23.
2005: Leuzzi Rosanna; Serino Laura; Scarselli Maria; Savino Silvana; Fontana Maria Rita; Monaci Elisabetta; Taddei Annarita; Fischer Gunter; Rappuoli Rino; Pizza Mariagrazia
Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages.
Molecular microbiology 2005;58(3):669-81.
2005: Baudner Barbara C; Verhoef J Coos; Giuliani Marzia M; Peppoloni Samuele; Rappuoli Rino; Del Giudice Giuseppe; Junginger Hans E
Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform.
Journal of drug targeting 2005;13(8-9):489-98.
2005: Torosantucci Antonella; Bromuro Carla; Chiani Paola; De Bernardis Flavia; Berti Francesco; Galli Chiara; Norelli Francesco; Bellucci Cinzia; Polonelli Luciano; Costantino Paolo; Rappuoli Rino; Cassone Antonio
A novel glyco-conjugate vaccine against fungal pathogens.
The Journal of experimental medicine 2005;202(5):597-606.
2005: Baraldo Karin; Mori Elena; Bartoloni Antonella; Norelli Francesco; Grandi Guido; Rappuoli Rino; Finco Oretta; Del Giudice Giuseppe
Combined conjugate vaccines: enhanced immunogenicity with the N19 polyepitope as a carrier protein.
Infection and immunity 2005;73(9):5835-41.
2005: Stadler Konrad; Roberts Anjeanette; Becker Stephan; Vogel Leatrice; Eickmann Markus; Kolesnikova Larissa; Klenk Hans-Dieter; Murphy Brian; Rappuoli Rino; Abrignani Sergio; Subbarao Kanta
SARS vaccine protective in mice.
Emerging infectious diseases 2005;11(8):1312-4.
2005: Wack Andreas; Rappuoli Rino
Vaccinology at the beginning of the 21st century.
Current opinion in immunology 2005;17(4):411-8.
2005: Maione Domenico; Margarit Immaculada; Rinaudo Cira D; Masignani Vega; Mora Marirosa; Scarselli Maria; Tettelin Hervé; Brettoni Cecilia; Iacobini Emilia T; Rosini Roberto; D'Agostino Nunzio; Miorin Lisa; Buccato Scilla; Mariani Massimo; Galli Giuliano; Nogarotto Renzo; Nardi Dei Vincenzo; Vegni Filipo; Fraser Claire; Mancuso Giuseppe; Teti Giuseppe; Madoff Lawrence C; Paoletti Lawrence C; Rappuoli Rino; Kasper Dennis L; Telford John L; Grandi Guido
Identification of a universal Group B streptococcus vaccine by multiple genome screen.
Science (New York, N.Y.) 2005;309(5731):148-50.
2005: Lauer Peter; Rinaudo Cira D; Soriani Marco; Margarit Immaculada; Maione Domenico; Rosini Roberto; Taddei Anna Rita; Mora Marirosa; Rappuoli Rino; Grandi Guido; Telford John L
Genome analysis reveals pili in Group B Streptococcus.
Science (New York, N.Y.) 2005;309(5731):105.
2005: Tonini Tiziana; Rappuoli Rino
[Genome and infectious diseases]
Recenti progressi in medicina 2005;96(5):245-7.
2005: Ieva Raffaele; Alaimo Cristina; Delany Isabel; Spohn Gunther; Rappuoli Rino; Scarlato Vincenzo
CrgA is an inducible LysR-type regulator of Neisseria meningitidis, acting both as a repressor and as an activator of gene transcription.
Journal of bacteriology 2005;187(10):3421-30.
2005: Barocchi Michèle A; Masignani Vega; Rappuoli Rino
Opinion: Cell entry machines: a common theme in nature?
Nature reviews. Microbiology 2005;3(4):349-58.
2005: Samdal Helvi Holm; Bakke Hilde; Oftung Fredrik; Holst Johan; Haugen Inger Lise; Korsvold Gro Ellen; Kristoffersen Anne-Cathrine; Krogh Grethe; Nord Karin; Rappuoli Rino; Berstad Aud Katrine Herland; Haneberg Bjørn
A non-living nasal influenza vaccine can induce major humoral and cellular immune responses in humans without the need for adjuvants.
Human vaccines 2005;1(2):85-90.
2005: Holst Johan; Feiring Berit; Naess Lisbeth M; Norheim Gunnstein; Kristiansen Paul; Høiby E Arne; Bryn Klaus; Oster Philipp; Costantino Paolo; Taha Muhamed-Kheir; Alonso Jean-Michel; Caugant Dominique A; Wedege Elisabeth; Aaberge Ingeborg S; Rappuoli Rino; Rosenqvist Einar
The concept of "tailor-made", protein-based, outer membrane vesicle vaccines against meningococcal disease.
Vaccine 2005;23(17-18):2202-5.
2005: Tonini Tiziana; Barnett Susan; Donnelly John; Rappuoli Rino
Current approaches to developing a preventative HIV vaccine.
Current opinion in investigational drugs (London, England : 2000) 2005;6(2):155-62.
2005: Giuliani Marzia Monica; Santini Laura; Brunelli Brunella; Biolchi Alessia; Aricò Beatrice; Di Marcello Federica; Cartocci Elena; Comanducci Maurizio; Masignani Vega; Lozzi Luisa; Savino Silvana; Scarselli Maria; Rappuoli Rino; Pizza Mariagrazia
The region comprising amino acids 100 to 255 of Neisseria meningitidis lipoprotein GNA 1870 elicits bactericidal antibodies.
Infection and immunity 2005;73(2):1151-60.
2005: Scarselli Maria; Giuliani Marzia M; Adu-Bobie Jeannette; Pizza Mariagrazia; Rappuoli Rino
The impact of genomics on vaccine design.
Trends in biotechnology 2005;23(2):84-91.
2005: Capecchi Barbara; Adu-Bobie Jeannette; Di Marcello Federica; Ciucchi Laura; Masignani Vega; Taddei Annarita; Rappuoli Rino; Pizza Mariagrazia; Aricò Beatrice
Neisseria meningitidis NadA is a new invasin which promotes bacterial adhesion to and penetration into human epithelial cells.
Molecular microbiology 2005;55(3):687-98.
2005: Robbins John B; Schneerson Rachel; Trollfors Birger; Sato Hiroko; Sato Yuji; Rappuoli Rino; Keith Jerry M
The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins.
The Journal of infectious diseases 2005;191(1):81-8.
2005: Kelly Dominic F; Rappuoli Rino
Reverse vaccinology and vaccines for serogroup B Neisseria meningitidis.
Advances in experimental medicine and biology 2005;568():217-23.
2005: Fraser Claire M; Rappuoli Rino
Application of microbial genomic science to advanced therapeutics.
Annual review of medicine 2005;56():459-74.
2004: Williams Andrew Evan; Edwards Lorna; Humphreys Ian Robert; Snelgrove Robert; Rae Aaron; Rappuoli Rino; Hussell Tracy
Innate imprinting by the modified heat-labile toxin of Escherichia coli (LTK63) provides generic protection against lung infectious disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7435-43.
2004: Rappuoli Rino
From Pasteur to genomics: progress and challenges in infectious diseases.
Nature medicine 2004;10(11):1177-85.
2004: De Gregorio Ennio; Rappuoli Rino
Inside sensors detecting outside pathogens.
Nature immunology 2004;5(11):1099-100.
2004: O'Hagan Derek T; Rappuoli Rino
The safety of vaccines.
Drug discovery today 2004;9(19):846-54.
2004: Litt David J; Savino Silvana; Beddek Amanda; Comanducci Maurizio; Sandiford Colin; Stevens Julia; Levin Michael; Ison Cathy; Pizza Mariagrazia; Rappuoli Rino; Kroll J Simon
Putative vaccine antigens from Neisseria meningitidis recognized by serum antibodies of young children convalescing after meningococcal disease.
The Journal of infectious diseases 2004;190(8):1488-97.
2004: Song Hyun Chul; Seo Mi-Young; Stadler Konrad; Yoo Byoung J; Choo Qui-Lim; Coates Stephen R; Uematsu Yasushi; Harada Takashi; Greer Catherine E; Polo John M; Pileri Piero; Eickmann Markus; Rappuoli Rino; Abrignani Sergio; Houghton Michael; Han Jang H
Synthesis and characterization of a native, oligomeric form of recombinant severe acute respiratory syndrome coronavirus spike glycoprotein.
Journal of virology 2004;78(19):10328-35.
2004: O'Hagan Derek T; Rappuoli Rino
Novel approaches to vaccine delivery.
Pharmaceutical research 2004;21(9):1519-30.
2004: Serruto Davide; Adu-Bobie Jeannette; Capecchi Barbara; Rappuoli Rino; Pizza Mariagrazia; Masignani Vega
Biotechnology and vaccines: application of functional genomics to Neisseria meningitidis and other bacterial pathogens.
Journal of biotechnology 2004;113(1-3):15-32.
2004: Mawas Fatme; Peyre Marisa; Beignon Anne-Sophie; Frost Laura; Del Giudice Giuseppe; Rappuoli Rino; Muller Sylviane; Sesardic Dorothea; Partidos Charalambos D
Successful induction of protective antibody responses against Haemophilus influenzae type b and diphtheria after transcutaneous immunization with the glycoconjugate polyribosyl ribitol phosphate-cross-reacting material 197 vaccine.
The Journal of infectious diseases 2004;190(6):1177-82.
2004: Baraldo Karin; Mori Elena; Bartoloni Antonella; Petracca Roberto; Giannozzi Aldo; Norelli Francesco; Rappuoli Rino; Grandi Guido; Del Giudice Giuseppe
N19 polyepitope as a carrier for enhanced immunogenicity and protective efficacy of meningococcal conjugate vaccines.
Infection and immunity 2004;72(8):4884-7.
2004: Traggiai Elisabetta; Becker Stephan; Subbarao Kanta; Kolesnikova Larissa; Uematsu Yasushi; Gismondo Maria Rita; Murphy Brian R; Rappuoli Rino; Lanzavecchia Antonio
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus.
Nature medicine 2004;10(8):871-5.
2004: Comanducci Maurizio; Bambini Stefania; Caugant Dominique A; Mora Marirosa; Brunelli Brunella; Capecchi Barbara; Ciucchi Laura; Rappuoli Rino; Pizza Mariagrazia
NadA diversity and carriage in Neisseria meningitidis.
Infection and immunity 2004;72(7):4217-23.
2004: Bowe Frances; Lavelle Ed C; McNeela Edel A; Hale Christine; Clare Simon; Arico Beatrice; Giuliani Marzia M; Rae Aaron; Huett Alan; Rappuoli Rino; Dougan Gordon; Mills Kingston H G
Mucosal vaccination against serogroup B meningococci: induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin.
Infection and immunity 2004;72(7):4052-60.
2004: Lattanzi Maria; Rappuoli Rino
Long-term solutions for the problem of vaccine shortages.
Expert opinion on biological therapy 2004;4(6):989-92.
2004: Rossi Giacomo; Ruggiero Paolo; Peppoloni Samuele; Pancotto Laura; Fortuna Damiano; Lauretti Laura; Volpini Gianfranco; Mancianti Silvia; Corazza Michele; Taccini Ennio; Di Pisa Francesco; Rappuoli Rino; Del Giudice Giuseppe
Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy.
Infection and immunity 2004;72(6):3252-9.
2004: Delany Isabel; Rappuoli Rino; Scarlato Vincenzo
Fur functions as an activator and as a repressor of putative virulence genes in Neisseria meningitidis.
Molecular microbiology 2004;52(4):1081-90.
2004: Spohn Gunther; Danielli Alberto; Roncarati Davide; Delany Isabel; Rappuoli Rino; Scarlato Vincenzo
Dual control of Helicobacter pylori heat shock gene transcription by HspR and HrcA.
Journal of bacteriology 2004;186(10):2956-65.
2004: de Bernard Marina; Cappon Andrea; Del Giudice Giuseppe; Rappuoli Rino; Montecucco Cesare
The multiple cellular activities of the VacA cytotoxin of Helicobacter pylori.
International journal of medical microbiology : IJMM 2004;293(7-8):589-97.
2004: Masignani Vega; Balducci Enrico; Serruto Davide; Veggi Daniele; Aricò Beatrice; Comanducci Maurizio; Pizza Mariagrazia; Rappuoli Rino
In silico identification of novel bacterial ADP-ribosyltransferases.
International journal of medical microbiology : IJMM 2004;293(7-8):471-8.
2004: Rossi Giacomo; Romagnoli Stefano; Lauretti Laura; Pancotto Laura; Taccini Ennio; Rappuoli Rino; Del Giudice Giuseppe; Ruggiero Paolo
Helicobacter pylori infection negatively influences pregnancy outcome in a mouse model.
Helicobacter 2004;9(2):152-7.
2004: Adu-Bobie Jeannette; Lupetti Pietro; Brunelli Brunella; Granoff Dan; Norais Nathalie; Ferrari Germano; Grandi Guido; Rappuoli Rino; Pizza Mariagrazia
GNA33 of Neisseria meningitidis is a lipoprotein required for cell separation, membrane architecture, and virulence.
Infection and immunity 2004;72(4):1914-9.
2004: Baudner Barbara C; Morandi Maurizio; Giuliani Marzia M; Verhoef J Coos; Junginger Hans E; Costantino Paolo; Rappuoli Rino; Del Giudice Giuseppe
Modulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery system.
The Journal of infectious diseases 2004;189(5):828-32.
2004: McNeela Edel A; Jabbal-Gill Inderjit; Illum Lisbeth; Pizza Mariagrazia; Rappuoli Rino; Podda Audino; Lewis David J M; Mills Kingston H G
Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: enhancement of Th2 responses and toxin-neutralizing antibodies by formulation with chitosan.
Vaccine 2004;22(8):909-14.
2004: De Groot Anne S; Rappuoli Rino
Genome-derived vaccines.
Expert review of vaccines 2004;3(1):59-76.
2004: Mazzantini Rogerio P; Miyaji Eliane N; Dias Waldely O; Sakauchi Dirce; Nascimento Ana Lúcia T O; Raw Isaías; Winter Nathalie; Gicquel Brigitte; Rappuoli Rino; Leite Luciana C C
Adjuvant activity of Mycobacterium bovis BCG expressing CRM197 on the immune response induced by BCG expressing tetanus toxin fragment C.
Vaccine 2004;22(5-6):740-6.
2004: Dubreuil J Daniel; Ruggiero Paolo; Rappuoli Rino; Del Giudice Giuseppe
Effect of heparin binding on Helicobacter pylori resistance to serum.
Journal of medical microbiology 2004;53(Pt 1):9-12.
2004: Capecchi Barbara; Serruto Davide; Adu-Bobie Jeannette; Rappuoli Rino; Pizza Mariagrazia
The genome revolution in vaccine research.
Current issues in molecular biology 2004;6(1):17-27.
2003: Stadler Konrad; Masignani Vega; Eickmann Markus; Becker Stephan; Abrignani Sergio; Klenk Hans-Dieter; Rappuoli Rino
SARS--beginning to understand a new virus.
Nature reviews. Microbiology 2003;1(3):209-18.
2003: Welsch Jo Anne; Moe Gregory R; Rossi Raffaella; Adu-Bobie Jeannette; Rappuoli Rino; Granoff Dan M
Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity.
The Journal of infectious diseases 2003;188(11):1730-40.
2003: Eickmann Markus; Becker Stephan; Klenk Hans-Dieter; Doerr Hans Wilhelm; Stadler Konrad; Censini Stefano; Guidotti Silvia; Masignani Vega; Scarselli Maria; Mora Marirosa; Donati Claudio; Han Jang H; Song Hyun Chul; Abrignani Sergio; Covacci Antonello; Rappuoli Rino
Phylogeny of the SARS coronavirus.
Science (New York, N.Y.) 2003;302(5650):1504-5.
2003: Delany Isabel; Spohn Gunther; Rappuoli Rino; Scarlato Vincenzo
An anti-repression Fur operator upstream of the promoter is required for iron-mediated transcriptional autoregulation in Helicobacter pylori.
Molecular microbiology 2003;50(4):1329-38.
2003: Masignani Vega; Balducci Enrico; Di Marcello Federica; Savino Silvana; Serruto Davide; Veggi Daniele; Bambini Stefania; Scarselli Maria; Aricò Beatrice; Comanducci Maurizio; Adu-Bobie Jeannette; Giuliani Marzia M; Rappuoli Rino; Pizza Mariagrazia
NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis.
Molecular microbiology 2003;50(3):1055-67.
2003: Rappuoli Rino; Covacci Antonello
Reverse vaccinology and genomics.
Science (New York, N.Y.) 2003;302(5645):602.
2003: Delany Isabel; Ieva Raffaele; Alaimo Cristina; Rappuoli Rino; Scarlato Vincenzo
The iron-responsive regulator fur is transcriptionally autoregulated and not essential in Neisseria meningitidis.
Journal of bacteriology 2003;185(20):6032-41.
2003: Tierney Rob; Beignon Anne-Sophie; Rappuoli Rino; Muller Sylviane; Sesardic Dorothea; Partidos Charalambos D
Transcutaneous immunization with tetanus toxoid and mutants of Escherichia coli heat-labile enterotoxin as adjuvants elicits strong protective antibody responses.
The Journal of infectious diseases 2003;188(5):753-8.
2003: Marinaro Mariarosaria; Riccomi Antonella; Rappuoli Rino; Pizza Mariagrazia; Fiorelli Valeria; Tripiciano Antonella; Cafaro Aurelio; Ensoli Barbara; De Magistris Maria Teresa
Mucosal delivery of the human immunodeficiency virus-1 Tat protein in mice elicits systemic neutralizing antibodies, cytotoxic T lymphocytes and mucosal IgA.
Vaccine 2003;21(25-26):3972-81.
2003: Baudner Barbara C; Giuliani Marzia M; Verhoef J Coos; Rappuoli Rino; Junginger Hans E; Giudice Giuseppe Del
The concomitant use of the LTK63 mucosal adjuvant and of chitosan-based delivery system enhances the immunogenicity and efficacy of intranasally administered vaccines.
Vaccine 2003;21(25-26):3837-44.
2003: Ulmer Jeffrey B; Rappuoli Rino
DNA vaccination.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2003;Chapter 13():Unit 13.2.
2003: Grifantini Renata; Sebastian Shite; Frigimelica Elisabetta; Draghi Monia; Bartolini Erika; Muzzi Alessandro; Rappuoli Rino; Grandi Guido; Genco Caroline Attardo
Identification of iron-activated and -repressed Fur-dependent genes by transcriptome analysis of Neisseria meningitidis group B.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9542-7.
2003: Passerini de Rossi Beatriz N; Friedman Laura E; Belzoni Cora B; Savino Silvana; Aricò Beatrice; Rappuoli Rino; Masignani Vega; Franco Mirta A
Vir90, a virulence-activated gene coding for a Bordetella pertussis iron-regulated outer membrane protein.
Research in microbiology 2003;154(6):443-50.
2003: Rappuoli Rino
The real cost of an affordable vaccine for meningococcus A.
Lancet 2003;362(9379):250-1; author reply 251.
2003: Ruggiero Paolo; Peppoloni Samuele; Rappuoli Rino; Del Giudice Giuseppe
The quest for a vaccine against Helicobacter pylori: how to move from mouse to man?
Microbes and infection / Institut Pasteur 2003;5(8):749-56.
2003: Masignani Vega; Lattanzi Maria; Rappuoli Rino
The value of vaccines.
Vaccine 2003;21 Suppl 2():S110-3.
2003: Boraschi Diana; Tagliabue Aldo; Martin Michael U; Rappuoli Rino
INNAMORA, a European Workshop focussed on the mechanisms of innate immunity in pathogen-host interaction and their exploitation in novel mucosal immunisation strategies.
Vaccine 2003;21 Suppl 2():S1-11.
2003: Mora Marirosa; Veggi Daniele; Santini Laura; Pizza Mariagrazia; Rappuoli Rino
Reverse vaccinology.
Drug discovery today 2003;8(10):459-64.
2003: Peppoloni Samuele; Ruggiero Paolo; Contorni Mario; Morandi Maurizio; Pizza Mariagrazia; Rappuoli Rino; Podda Audino; Del Giudice Giuseppe
Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines.
Expert review of vaccines 2003;2(2):285-93.
2003: Serruto Davide; Adu-Bobie Jeannette; Scarselli Maria; Veggi Daniele; Pizza Mariagrazia; Rappuoli Rino; Aricò Beatrice
Neisseria meningitidis App, a new adhesin with autocatalytic serine protease activity.
Molecular microbiology 2003;48(2):323-34.
2003: Nishioka Hiroaki; Baesso Ilenia; Semenzato Gianpietro; Trentin Livio; Rappuoli Rino; Del Giudice Giuseppe; Montecucco Cesare
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils.
European journal of immunology 2003;33(4):840-9.
2003: Covacci Antonello; Rappuoli Rino
Helicobacter pylori: after the genomes, back to biology.
The Journal of experimental medicine 2003;197(7):807-11.
2003: Masignani Vega; Comanducci Maurizio; Giuliani Marzia Monica; Bambini Stefania; Adu-Bobie Jeannette; Arico Beatrice; Brunelli Brunella; Pieri Alessandro; Santini Laura; Savino Silvana; Serruto Davide; Litt David; Kroll Simon; Welsch Jo Anne; Granoff Dan M; Rappuoli Rino; Pizza Mariagrazia
Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870.
The Journal of experimental medicine 2003;197(6):789-99.
2003: Mills Kingston H G; Cosgrove Catherine; McNeela Edel A; Sexton Amy; Giemza Rafaela; Jabbal-Gill Inderjit; Church Anne; Lin Wu; Illum Lisbeth; Podda Audino; Rappuoli Rino; Pizza Mariagrazia; Griffin George E; Lewis David J M
Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a.
Infection and immunity 2003;71(2):726-32.
2003: Adu-Bobie Jeannette; Capecchi Barbara; Serruto Davide; Rappuoli Rino; Pizza Mariagrazia
Two years into reverse vaccinology.
Vaccine 2003;21(7-8):605-10.
2003: Pizza Mariagrazia; Fontana Maria Rita; Scarlato Vincenzo; Rappuoli Rino
Genetic detoxification of bacterial toxins.
Methods in molecular medicine 2003;87():133-52.
2002: Masignani Vega; Rappuoli Rino; Pizza Mariagrazia
Reverse vaccinology: a genome-based approach for vaccine development.
Expert opinion on biological therapy 2002;2(8):895-905.
2002: Dubreuil J Daniel; Giudice Giuseppe Del; Rappuoli Rino
Helicobacter pylori interactions with host serum and extracellular matrix proteins: potential role in the infectious process.
Microbiology and molecular biology reviews : MMBR 2002;66(4):617-29, table of contents.
2002: Delany Isabel; Spohn Gunther; Pacheco Ana-Beatriz F; Ieva Raffaele; Alaimo Cristina; Rappuoli Rino; Scarlato Vincenzo
Autoregulation of Helicobacter pylori Fur revealed by functional analysis of the iron-binding site.
Molecular microbiology 2002;46(4):1107-22.
2002: Seydel Anke; Tasca Elisabetta; Berti Duccio; Rappuoli Rino; Del Giudice Giuseppe; Montecucco Cesare
Characterization and immunogenicity of the CagF protein of the cag pathogenicity island of Helicobacter pylori.
Infection and immunity 2002;70(11):6468-70.
2002: Zanotti Giuseppe; Papinutto Elena; Dundon William; Battistutta Roberto; Seveso Michela; Giudice Giuseppe; Rappuoli Rino; Montecucco Cesare
Structure of the neutrophil-activating protein from Helicobacter pylori.
Journal of molecular biology 2002;323(1):125-30.
2002: Peppoloni Samuele; Mancianti Silvia; Volpini Gianfranco; Nuti Sandra; Ruggiero Paolo; Rappuoli Rino; Blasi Elisabetta; Del Giudice Giuseppe
Antibody-dependent macrophage-mediated activity against Helicobacter pylori in the absence of complement.
European journal of immunology 2002;32(10):2721-5.
2002: Baudner B C; Balland O; Giuliani M M; Von Hoegen P; Rappuoli R; Betbeder D; Del Giudice G
Enhancement of protective efficacy following intranasal immunization with vaccine plus a nontoxic LTK63 mutant delivered with nanoparticles.
Infection and immunity 2002;70(9):4785-90.
2002: Grifantini Renata; Bartolini Erika; Muzzi Alessandro; Draghi Monia; Frigimelica Elisabetta; Berger Joel; Ratti Giulio; Petracca Roberto; Galli Giuliano; Agnusdei Mauro; Giuliani Marzia Monica; Santini Laura; Brunelli Brunella; Tettelin Hervé; Rappuoli Rino; Randazzo Filippo; Grandi Guido
Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays.
Nature biotechnology 2002;20(9):914-21.
2002: Delany Isabel; Spohn Gunther; Rappuoli Rino; Scarlato Vincenzo
Growth phase-dependent regulation of target gene promoters for binding of the essential orphan response regulator HP1043 of Helicobacter pylori.
Journal of bacteriology 2002;184(17):4800-10.
2002: Rappuoli Rino; Miller Henry I; Falkow Stanley
Medicine. The intangible value of vaccination.
Science (New York, N.Y.) 2002;297(5583):937-9.
2002: Jennings Gary T; Savino Silvana; Marchetti Elisa; Aricò Beatrice; Kast Thomas; Baldi Lucia; Ursinus Astrid; Höltje Joachim-Volker; Nicholas Robert A; Rappuoli Rino; Grandi Guido
GNA33 from Neisseria meningitidis serogroup B encodes a membrane-bound lytic transglycosylase (MltA).
European journal of biochemistry / FEBS 2002;269(15):3722-31.
2002: Ruggiero Paolo; Peppoloni Samuele; Berti Duccio; Rappuoli Rino; Giudice Giuseppe Del
New strategies for the prevention and treatment of Helicobacter pylori infection.
Expert opinion on investigational drugs 2002;11(8):1127-38.
2002: Comanducci Maurizio; Bambini Stefania; Brunelli Brunella; Adu-Bobie Jeannette; Aricò Beatrice; Capecchi Barbara; Giuliani Marzia Monica; Masignani Vega; Santini Laura; Savino Silvana; Granoff Dan M; Caugant Dominique A; Pizza Mariagrazia; Rappuoli Rino; Mora Marirosa
NadA, a novel vaccine candidate of Neisseria meningitidis.
The Journal of experimental medicine 2002;195(11):1445-54.
2002: Beignon A-S; Briand J-P; Rappuoli R; Muller S; Partidos C D
The LTR72 mutant of heat-labile enterotoxin of Escherichia coli enhances the ability of peptide antigens to elicit CD4(+) T cells and secrete gamma interferon after coapplication onto bare skin.
Infection and immunity 2002;70(6):3012-9.
2002: Spohn Gunther; Delany Isabel; Rappuoli Rino; Scarlato Vincenzo
Characterization of the HspR-mediated stress response in Helicobacter pylori.
Journal of bacteriology 2002;184(11):2925-30.
2002: Marchetti Marta; Rappuoli Rino
Isogenic mutants of the cag pathogenicity island of Helicobacter pylori in the mouse model of infection: effects on colonization efficiency.
Microbiology (Reading, England) 2002;148(Pt 5):1447-56.
2002: Montemurro Pasqualina; Nishioka Hiroaki; Dundon William G; de Bernard Marina; Del Giudice Giuseppe; Rappuoli Rino; Montecucco Cesare
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells.
European journal of immunology 2002;32(3):671-6.
2002: Stein Markus; Bagnoli Fabio; Halenbeck Robert; Rappuoli Rino; Fantl Wendy J; Covacci Antonello
c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs.
Molecular microbiology 2002;43(4):971-80.
2002: Dundon William G; Nishioka Hiroaki; Polenghi Alessandra; Papinutto Elena; Zanotti Giuseppe; Montemurro Pasqualina; Del Giudice Giuseppe; Rappuoli Rino; Montecucco Cesare
The neutrophil-activating protein of Helicobacter pylori.
International journal of medical microbiology : IJMM 2002;291(6-7):545-50.
2002: Delany Isabel; Spohn Gunther; Rappuoli Rino; Scarlato Vincenzo
In vitro selection of high affinity HspR-binding sites within the genome of Helicobacter pylori.
Gene 2002;283(1-2):63-9.
2002: Ji Xuhuai; Frati Francesco; Barone Silvia; Pagliaccia Cristina; Burroni Daniela; Xu Guoming; Rappuoli Rino; Reyrat Jean-Marc; Telford John L
Evolution of functional polymorphism in the gene coding for the Helicobacter pylori cytotoxin.
FEMS microbiology letters 2002;206(2):253-8.
2002: Moxon Richard; Rappuoli Rino
Bacterial pathogen genomics and vaccines.
British medical bulletin 2002;62():45-58.
2001: Delany I; Spohn G; Rappuoli R; Scarlato V
The Fur repressor controls transcription of iron-activated and -repressed genes in Helicobacter pylori.
Molecular microbiology 2001;42(5):1297-309.
2001: Falugi F; Petracca R; Mariani M; Luzzi E; Mancianti S; Carinci V; Melli M L; Finco O; Wack A; Di Tommaso A; De Magistris M T; Costantino P; Del Giudice G; Abrignani S; Rappuoli R; Grandi G
Rationally designed strings of promiscuous CD4(+) T cell epitopes provide help to Haemophilus influenzae type b oligosaccharide: a model for new conjugate vaccines.
European journal of immunology 2001;31(12):3816-24.
2001: Granoff D M; Moe G R; Giuliani M M; Adu-Bobie J; Santini L; Brunelli B; Piccinetti F; Zuno-Mitchell P; Lee S S; Neri P; Bracci L; Lozzi L; Rappuoli R
A novel mimetic antigen eliciting protective antibody to Neisseria meningitidis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6487-96.
2001: Morbiato L; Tombola F; Campello S; Del Giudice G; Rappuoli R; Zoratti M; Papini E
Vacuolation induced by VacA toxin of Helicobacter pylori requires the intracellular accumulation of membrane permeant bases, Cl(-) and water.
FEBS letters 2001;508(3):479-83.
2001: Del Giudice G; Podda A; Rappuoli R
What are the limits of adjuvanticity?
Vaccine 2001;20 Suppl 1():S38-41.
2001: Tombola F; Morbiato L; Del Giudice G; Rappuoli R; Zoratti M; Papini E
The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia.
The Journal of clinical investigation 2001;108(6):929-37.
2001: Delany I; Pacheco A B; Spohn G; Rappuoli R; Scarlato V
Iron-dependent transcription of the frpB gene of Helicobacter pylori is controlled by the Fur repressor protein.
Journal of bacteriology 2001;183(16):4932-7.
2001: Dundon W; Nishioka H; Montecucco C; Montemurro P; Rappuoli R; Del Giudice G
Problems assaying neutrophil activators.
Trends in microbiology 2001;9(7):314-5.
2001: Montecucco C; Rappuoli R
Living dangerously: how Helicobacter pylori survives in the human stomach.
Nature reviews. Molecular cell biology 2001;2(6):457-66.
2001: Dundon W G; Polenghi A; Del Guidice G; Rappuoli R; Montecucco C
Neutrophil-activating protein (HP-NAP) versus ferritin (Pfr): comparison of synthesis in Helicobacter pylori.
FEMS microbiology letters 2001;199(1):143-9.
2001: Masignani V; Giuliani M M; Tettelin H; Comanducci M; Rappuoli R; Scarlato V
Mu-like Prophage in serogroup B Neisseria meningitidis coding for surface-exposed antigens.
Infection and immunity 2001;69(4):2580-8.
2001: Montemurro P; Barbuti G; Dundon W G; Del Giudice G; Rappuoli R; Colucci M; De Rinaldis P; Montecucco C; Semeraro N; Papini E
Helicobacter pylori neutrophil-activating protein stimulates tissue factor and plasminogen activator inhibitor-2 production by human blood mononuclear cells.
The Journal of infectious diseases 2001;183(7):1055-62.
2001: Pizza M; Giuliani M M; Fontana M R; Monaci E; Douce G; Dougan G; Mills K H; Rappuoli R; Del Giudice G
Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.
Vaccine 2001;19(17-19):2534-41.
2001: Miyaji E N; Mazzantini R P; Dias W O; Nascimento A L; Marcovistz R; Matos D S; Raw I; Winter N; Gicquel B; Rappuoli R; Leite L C
Induction of neutralizing antibodies against diphtheria toxin by priming with recombinant Mycobacterium bovis BCG expressing CRM(197), a mutant diphtheria toxin.
Infection and immunity 2001;69(2):869-74.
2001: Scarselli M; Rappuoli R; Scarlato V
A common conserved amino acid motif module shared by bacterial and intercellular adhesins: bacterial adherence mimicking cell cell recognition?
Microbiology (Reading, England) 2001;147(Pt 2):250-2.
2001: Del Giudice G; Covacci A; Telford J L; Montecucco C; Rappuoli R
The design of vaccines against Helicobacter pylori and their development.
Annual review of immunology 2001;19():523-63.
2000: McNeela E A; O'Connor D; Jabbal-Gill I; Illum L; Davis S S; Pizza M; Peppoloni S; Rappuoli R; Mills K H
A mucosal vaccine against diphtheria: formulation of cross reacting material (CRM(197)) of diphtheria toxin with chitosan enhances local and systemic antibody and Th2 responses following nasal delivery.
Vaccine 2000;19(9-10):1188-98.
2000: Rappuoli R
Pushing the limits of cellular microbiology: microarrays to study bacteria-host cell intimate contacts.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13467-9.
2000: Ryan E J; McNeela E; Pizza M; Rappuoli R; O'Neill L; Mills K H
Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5750-9.
2000: Pizza M; Giuliani M M; Fontana M R; Douce G; Dougan G; Rappuoli R
LTK63 and LTR72, two mucosal adjuvants ready for clinical trials.
International journal of medical microbiology : IJMM 2000;290(4-5):455-61.
2000: Rappuoli R
Reverse vaccinology.
Current opinion in microbiology 2000;3(5):445-50.
2000: Nascimento I P; Dias W O; Mazzantini R P; Miyaji E N; Gamberini M; Quintilio W; Gebara V C; Cardoso D F; Ho P L; Raw I; Winter N; Gicquel B; Rappuoli R; Leite L C
Recombinant Mycobacterium bovis BCG expressing pertussis toxin subunit S1 induces protection against an intracerebral challenge with live Bordetella pertussis in mice.
Infection and immunity 2000;68(9):4877-83.
2000: Fontana M R; Monaci E; Yanqing L; Guoming Q; Duan G; Rappuoli R; Pizza M
IEM101, a naturally attenuated Vibrio cholerae strain as carrier for genetically detoxified derivatives of cholera toxin.
Vaccine 2000;19(1):75-85.
2000: Rossi G; Fortuna D; Pancotto L; Renzoni G; Taccini E; Ghiara P; Rappuoli R; Del Giudice G
Immunohistochemical study of lymphocyte populations infiltrating the gastric mucosa of beagle dogs experimentally infected with Helicobacter pylori.
Infection and immunity 2000;68(8):4769-72.
2000: Ji X; Fernandez T; Burroni D; Pagliaccia C; Atherton J C; Reyrat J M; Rappuoli R; Telford J L
Cell specificity of Helicobacter pylori cytotoxin is determined by a short region in the polymorphic midregion.
Infection and immunity 2000;68(6):3754-7.
2000: Satin B; Del Giudice G; Della Bianca V; Dusi S; Laudanna C; Tonello F; Kelleher D; Rappuoli R; Montecucco C; Rossi F
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor.
The Journal of experimental medicine 2000;191(9):1467-76.
2000: Covacci A; Rappuoli R
Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell.
The Journal of experimental medicine 2000;191(4):587-92.
2000: de Bernard M; Moschioni M; Napolitani G; Rappuoli R; Montecucco C
The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein.
The EMBO journal 2000;19(1):48-56.
2000: Ceccarini C; Contorni M; Costantino P; D'Ascenzi S; Gallo E; Maffei M; Mannucci D; Marsili I; Magagnoli C; Peppoloni S; Rappuoli R; Ravenscroft N; Ricci S
Physicochemical characterisation of the pertussis vaccine.
Developments in biologicals 2000;103():175-88.
1999: Simmons C P; Mastroeni P; Fowler R; Ghaem-maghami M; Lycke N; Pizza M; Rappuoli R; Dougan G
MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6502-10.
1999: Ryan E J; McNeela E; Murphy G A; Stewart H; O'hagan D; Pizza M; Rappuoli R; Mills K H
Mutants of Escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: differential effects of the nontoxic AB complex and enzyme activity on Th1 and Th2 cells.
Infection and immunity 1999;67(12):6270-80.
1999: Rappuoli R; Pizza M; Douce G; Dougan G
Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins.
Immunology today 1999;20(11):493-500.
1999: Tonello F; Dundon W G; Satin B; Molinari M; Tognon G; Grandi G; Del Giudice G; Rappuoli R; Montecucco C
The Helicobacter pylori neutrophil-activating protein is an iron-binding protein with dodecameric structure.
Molecular microbiology 1999;34(2):238-46.
1999: Reyrat J M; Pelicic V; Papini E; Montecucco C; Rappuoli R; Telford J L
Towards deciphering the Helicobacter pylori cytotoxin.
Molecular microbiology 1999;34(2):197-204.
1999: Szabò I; Brutsche S; Tombola F; Moschioni M; Satin B; Telford J L; Rappuoli R; Montecucco C; Papini E; Zoratti M
Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity.
The EMBO journal 1999;18(20):5517-27.
1999: Douce G; Giannelli V; Pizza M; Lewis D; Everest P; Rappuoli R; Dougan G
Genetically detoxified mutants of heat-labile toxin from Escherichia coli are able to act as oral adjuvants.
Infection and immunity 1999;67(9):4400-6.
1999: Pelicic V; Reyrat J M; Sartori L; Pagliaccia C; Rappuoli R; Telford J L; Montecucco C; Papini E
Helicobacter pylori VacA cytotoxin associated with the bacteria increases epithelial permeability independently of its vacuolating activity.
Microbiology (Reading, England) 1999;145 ( Pt 8)():2043-50.
1999: Reyrat J M; Lanzavecchia S; Lupetti P; de Bernard M; Pagliaccia C; Pelicic V; Charrel M; Ulivieri C; Norais N; Ji X; Cabiaux V; Papini E; Rappuoli R; Telford J L
3D imaging of the 58 kDa cell binding subunit of the Helicobacter pylori cytotoxin.
Journal of molecular biology 1999;290(2):459-70.
1999: Rossi G; Rossi M; Vitali C G; Fortuna D; Burroni D; Pancotto L; Capecchi S; Sozzi S; Renzoni G; Braca G; Del Giudice G; Rappuoli R; Ghiara P; Taccini E
A conventional beagle dog model for acute and chronic infection with Helicobacter pylori.
Infection and immunity 1999;67(6):3112-20.
1999: Covacci A; Telford J L; Del Giudice G; Parsonnet J; Rappuoli R
Helicobacter pylori virulence and genetic geography.
Science (New York, N.Y.) 1999;284(5418):1328-33.
1999: Costantino P; Norelli F; Giannozzi A; D'Ascenzi S; Bartoloni A; Kaur S; Tang D; Seid R; Viti S; Paffetti R; Bigio M; Pennatini C; Averani G; Guarnieri V; Gallo E; Ravenscroft N; Lazzeroni C; Rappuoli R; Ceccarini C
Size fractionation of bacterial capsular polysaccharides for their use in conjugate vaccines.
Vaccine 1999;17(9-10):1251-63.
1998: de Bernard M; Burroni D; Papini E; Rappuoli R; Telford J; Montecucco C
Identification of the Helicobacter pylori VacA toxin domain active in the cell cytosol.
Infection and immunity 1998;66(12):6014-6.
1998: Jabbal-Gill I; Fisher A N; Rappuoli R; Davis S S; Illum L
Stimulation of mucosal and systemic antibody responses against Bordetella pertussis filamentous haemagglutinin and recombinant pertussis toxin after nasal administration with chitosan in mice.
Vaccine 1998;16(20):2039-46.
1998: Burroni D; Lupetti P; Pagliaccia C; Reyrat J M; Dallai R; Rappuoli R; Telford J L
Deletion of the major proteolytic site of the Helicobacter pylori cytotoxin does not influence toxin activity but favors assembly of the toxin into hexameric structures.
Infection and immunity 1998;66(11):5547-50.
1998: Del Giudice G; Ghiara P; Rappuoli R
Experimental model of Helicobacter pylori infection.
Italian journal of gastroenterology and hepatology 1998;30 Suppl 3():S261-3.
1998: de Bernard M; Moschioni M; Papini E; Telford J; Rappuoli R; Montecucco C
Cell vacuolization induced by Helicobacter pylori VacA toxin: cell line sensitivity and quantitative estimation.
Toxicology letters 1998;99(2):109-15.
1998: Beier D; Spohn G; Rappuoli R; Scarlato V
Functional analysis of the Helicobacter pylori principal sigma subunit of RNA polymerase reveals that the spacer region is important for efficient transcription.
Molecular microbiology 1998;30(1):121-34.
1998: de Bernard M; Moschioni M; Papini E; Telford J L; Rappuoli R; Montecucco C
TPA and butyrate increase cell sensitivity to the vacuolating toxin of Helicobacter pylori.
FEBS letters 1998;436(2):218-22.
1998: Reyrat J M; Charrel M; Pagliaccia C; Burroni D; Lupetti P; de Bernard M; Ji X; Norais N; Papini E; Dallai R; Rappuoli R; Telford J L
Characterisation of a monoclonal antibody and its use to purify the cytotoxin of Helicobacter pylori.
FEMS microbiology letters 1998;165(1):79-84.
1998: Papini E; Satin B; Norais N; de Bernard M; Telford J L; Rappuoli R; Montecucco C
Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.
The Journal of clinical investigation 1998;102(4):813-20.
1998: Pagliaccia C; de Bernard M; Lupetti P; Ji X; Burroni D; Cover T L; Papini E; Rappuoli R; Telford J L; Reyrat J M
The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10212-7.
1998: Massari P; Manetti R; Burroni D; Nuti S; Norais N; Rappuoli R; Telford J L
Binding of the Helicobacter pylori vacuolating cytotoxin to target cells.
Infection and immunity 1998;66(8):3981-4.
1998: Douce G; Giuliani M M; Giannelli V; Pizza M G; Rappuoli R; Dougan G
Mucosal immunogenicity of genetically detoxified derivatives of heat labile toxin from Escherichia coli.
Vaccine 1998;16(11-12):1065-73.
1998: Molinari M; Galli C; de Bernard M; Norais N; Ruysschaert J M; Rappuoli R; Montecucco C
The acid activation of Helicobacter pylori toxin VacA: structural and membrane binding studies.
Biochemical and biophysical research communications 1998;248(2):334-40.
1998: Scarselli M; Esposito G; De Magistris M T; Domenighini M; Rappuoli R; Burroni G; Bernini A; Niccolai N
NMR studies on the structure/function correlations of T-cell-epitope analogs from pertussis toxin.
European journal of biochemistry / FEBS 1998;254(2):313-7.
1998: Ryan M; McCarthy L; Rappuoli R; Mahon B P; Mills K H
Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28.
International immunology 1998;10(5):651-62.
1998: Giuliani M M; Del Giudice G; Giannelli V; Dougan G; Douce G; Rappuoli R; Pizza M
Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity.
The Journal of experimental medicine 1998;187(7):1123-32.
1998: Chen I; Finn T M; Yanqing L; Guoming Q; Rappuoli R; Pizza M
A recombinant live attenuated strain of Vibrio cholerae induces immunity against tetanus toxin and Bordetella pertussis tracheal colonization factor.
Infection and immunity 1998;66(4):1648-53.
1998: Covacci A; Rappuoli R
Helicobacter pylori: molecular evolution of a bacterial quasi-species.
Current opinion in microbiology 1998;1(1):96-102.
1998: Marchetti M; Rossi M; Giannelli V; Giuliani M M; Pizza M; Censini S; Covacci A; Massari P; Pagliaccia C; Manetti R; Telford J L; Douce G; Dougan G; Rappuoli R; Ghiara P
Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant.
Vaccine 1998;16(1):33-7.
1998: Lanzavecchia S; Bellon P L; Lupetti P; Dallai R; Rappuoli R; Telford J L
Three-dimensional reconstruction of metal replicas of the Helicobacter pylori vacuolating cytotoxin.
Journal of structural biology 1998;121(1):9-18.
1998: Molinari M; Salio M; Galli C; Norais N; Rappuoli R; Lanzavecchia A; Montecucco C
Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA.
The Journal of experimental medicine 1998;187(1):135-40.
1998: Papini E; Satin B; de Bernard M; Molinari M; Aricò B; Galli C; Telford J R; Rappuoli R; Montecucco C
Action site and cellular effects of cytotoxin VacA produced by Helicobacter pylori.
Folia microbiologica 1998;43(3):279-84.
1998: Rappuoli R; Lange C; Censini S; Covacci A
Pathogenicity island mediates Helicobacter pylori interaction with the host.
Folia microbiologica 1998;43(3):275-8.
1998: De Magistris M T; Pizza M; Douce G; Ghiara P; Dougan G; Rappuoli R
Adjuvant effect of non-toxic mutants of E. coli heat-labile enterotoxin following intranasal, oral and intravaginal immunization.
Developments in biological standardization 1998;92():123-6.
1997: Ghiara P; Rossi M; Marchetti M; Di Tommaso A; Vindigni C; Ciampolini F; Covacci A; Telford J L; De Magistris M T; Pizza M; Rappuoli R; Del Giudice G
Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection.
Infection and immunity 1997;65(12):4996-5002.
1997: de Bernard M; Arico B; Papini E; Rizzuto R; Grandi G; Rappuoli R; Montecucco C
Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosol.
Molecular microbiology 1997;26(4):665-74.
1997: Manetti R; Massari P; Marchetti M; Magagnoli C; Nuti S; Lupetti P; Ghiara P; Rappuoli R; Telford J L
Detoxification of the Helicobacter pylori cytotoxin.
Infection and immunity 1997;65(11):4615-9.
1997: Pagliaccia C; Manetti R; Rappuoli R
Pertactin antigens extracted from Bordetella pertussis and Bordetella bronchiseptica differ in the isoelectric point.
Archives of microbiology 1997;168(5):437-40.
1997: Spohn G; Beier D; Rappuoli R; Scarlato V
Transcriptional analysis of the divergent cagAB genes encoded by the pathogenicity island of Helicobacter pylori.
Molecular microbiology 1997;26(2):361-72.
1997: Molinari M; Galli C; Norais N; Telford J L; Rappuoli R; Luzio J P; Montecucco C
Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers.
The Journal of biological chemistry 1997;272(40):25339-44.
1997: Satin B; Norais N; Telford J; Rappuoli R; Murgia M; Montecucco C; Papini E
Effect of helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation.
The Journal of biological chemistry 1997;272(40):25022-8.
1997: Di Tommaso A; Bartalini M; Peppoloni S; Podda A; Rappuoli R; De Magistris M T
Acellular pertussis vaccines containing genetically detoxified pertussis toxin induce long-lasting humoral and cellular responses in adults.
Vaccine 1997;15(11):1218-24.
1997: Beier D; Spohn G; Rappuoli R; Scarlato V
Identification and characterization of an operon of Helicobacter pylori that is involved in motility and stress adaptation.
Journal of bacteriology 1997;179(15):4676-83.
1997: Douce G; Fontana M; Pizza M; Rappuoli R; Dougan G
Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin.
Infection and immunity 1997;65(7):2821-8.
1997: Wülfing C; Rappuoli R
Efficient production of heat-labile enterotoxin mutant proteins by overexpression of dsbA in a degP-deficient Escherichia coli strain.
Archives of microbiology 1997;167(5):280-3.
1997: Papini E; Satin B; Bucci C; de Bernard M; Telford J L; Manetti R; Rappuoli R; Zerial M; Montecucco C
The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin.
The EMBO journal 1997;16(1):15-24.
1997: Giannelli V; Fontana M R; Giuliani M M; Guangcai D; Rappuoli R; Pizza M
Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop.
Infection and immunity 1997;65(1):331-4.
1996: Magagnoli C; Manetti R; Fontana M R; Giannelli V; Giuliani M M; Rappuoli R; Pizza M
Mutations in the A subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin.
Infection and immunity 1996;64(12):5434-8.
1996: Papini E; Gottardi E; Satin B; de Bernard M; Massari P; Telford J; Rappuoli R; Sato S B; Montecucco C
The vacuolar ATPase proton pump is present on intracellular vacuoles induced by Helicobacter pylori.
Journal of medical microbiology 1996;45(2):84-9.
1996: Lupetti P; Heuser J E; Manetti R; Massari P; Lanzavecchia S; Bellon P L; Dallai R; Rappuoli R; Telford J L
Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin.
The Journal of cell biology 1996;133(4):801-7.
1996: Zu T; Goyard S; Rappuoli R; Scarlato V
DNA binding of the Bordetella pertussis H1 homolog alters in vitro DNA flexibility.
Journal of bacteriology 1996;178(10):2982-5.
1996: Di Tommaso A; Saletti G; Pizza M; Rappuoli R; Dougan G; Abrignani S; Douce G; De Magistris M T
Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant.
Infection and immunity 1996;64(3):974-9.
1996: Rappuoli R
Acellular pertussis vaccines: a turning point in infant and adolescent vaccination.
Infectious agents and disease 1996;5(1):21-8.
1996: Cossart P; Boquet P; Normark S; Rappuoli R
Cellular microbiology emerging.
Science (New York, N.Y.) 1996;271(5247):315-6.
1996: Petre J; Pizza M; Nencioni L; Podda A; De Magistris M T; Rappuoli R
The reaction of bacterial toxins with formaldehyde and its use for antigen stabilization.
Developments in biological standardization 1996;87():125-34.
1995: Cropley I; Douce G; Roberts M; Chatfield S; Pizza M; Marsili I; Rappuoli R; Dougan G
Mucosal and systemic immunogenicity of a recombinant, non-ADP-ribosylating pertussis toxin: effects of formaldehyde treatment.
Vaccine 1995;13(17):1643-8.
1995: Moll G; Papini E; Colonna R; Burroni D; Telford J; Rappuoli R; Montecucco C
Lipid interaction of the 37-kDa and 58-kDa fragments of the Helicobacter pylori cytotoxin.
European journal of biochemistry / FEBS 1995;234(3):947-52.
1995: Rappuoli R; Douce G; Dougan G; Pizza M
Genetic detoxification of bacterial toxins: a new approach to vaccine development.
International archives of allergy and immunology 1995;108(4):327-33.
1995: Manetti R; Massari P; Burroni D; de Bernard M; Marchini A; Olivieri R; Papini E; Montecucco C; Rappuoli R; Telford J L
Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies.
Infection and immunity 1995;63(11):4476-80.
1995: de Bernard M; Papini E; de Filippis V; Gottardi E; Telford J; Manetti R; Fontana A; Rappuoli R; Montecucco C
Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant.
The Journal of biological chemistry 1995;270(41):23937-40.
1995: Prugnola A; Aricò B; Manetti R; Rappuoli R; Scarlato V
Response of the bvg regulon of Bordetella pertussis to different temperatures and short-term temperature shifts.
Microbiology (Reading, England) 1995;141 ( Pt 10)():2529-34.
1995: Podda A; Bona G; Canciani G; Pistilli A M; Contu B; Furlan R; Meloni T; Stramare D; Titone L; Rappuoli R
Effect of priming with diphtheria and tetanus toxoids combined with whole-cell pertussis vaccine or with acellular pertussis vaccine on the safety and immunogenicity of a booster dose of an acellular pertussis vaccine containing a genetically inactivated pertussis toxin in fifteen- to twenty-one-month-old children. Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine.
The Journal of pediatrics 1995;127(2):238-43.
1995: Fontana M R; Manetti R; Giannelli V; Magagnoli C; Marchini A; Olivieri R; Domenighini M; Rappuoli R; Pizza M
Construction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit.
Infection and immunity 1995;63(6):2356-60.
1995: Roberts M; Bacon A; Rappuoli R; Pizza M; Cropley I; Douce G; Dougan G; Marinaro M; McGhee J; Chatfield S
A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins.
Infection and immunity 1995;63(6):2100-8.
1995: Bartoloni A; Norelli F; Ceccarini C; Rappuoli R; Costantino P
Immunogenicity of meningococcal B polysaccharide conjugated to tetanus toxoid or CRM197 via adipic acid dihydrazide.
Vaccine 1995;13(5):463-70.
1995: Marchetti M; Aricò B; Burroni D; Figura N; Rappuoli R; Ghiara P
Development of a mouse model of Helicobacter pylori infection that mimics human disease.
Science (New York, N.Y.) 1995;267(5204):1655-8.
1995: Di Tommaso A; Xiang Z; Bugnoli M; Pileri P; Figura N; Bayeli P F; Rappuoli R; Abrignani S; De Magistris M T
Helicobacter pylori-specific CD4+ T-cell clones from peripheral blood and gastric biopsies.
Infection and immunity 1995;63(3):1102-6.
1995: Domenighini M; Pizza M; Jobling M G; Holmes R K; Rappuoli R
Identification of errors among database sequence entries and comparison of correct amino acid sequences for the heat-labile enterotoxins of Escherichia coli and Vibrio cholerae.
Molecular microbiology 1995;15(6):1165-7.
1995: Scarlato V; Aricò B; Goyard S; Ricci S; Manetti R; Prugnola A; Manetti R; Polverino-De-Laureto P; Ullmann A; Rappuoli R
A novel chromatin-forming histone H1 homologue is encoded by a dispensable and growth-regulated gene in Bordetella pertussis.
Molecular microbiology 1995;15(5):871-81.
1995: Douce G; Turcotte C; Cropley I; Roberts M; Pizza M; Domenghini M; Rappuoli R; Dougan G
Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1644-8.
1995: Xiang Z; Censini S; Bayeli P F; Telford J L; Figura N; Rappuoli R; Covacci A
Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin.
Infection and immunity 1995;63(1):94-8.
1995: Peppoloni S; Pizza M; De Magistris M T; Bartoloni A; Rappuoli R
Acellular pertussis vaccine composed of genetically inactivated pertussis toxin.
Physiological chemistry and physics and medical NMR 1995;27(4):355-61.
1994: Pizza M; Fontana M R; Giuliani M M; Domenighini M; Magagnoli C; Giannelli V; Nucci D; Hol W; Manetti R; Rappuoli R
A genetically detoxified derivative of heat-labile Escherichia coli enterotoxin induces neutralizing antibodies against the A subunit.
The Journal of experimental medicine 1994;180(6):2147-53.
1994: Manetti R; Aricò B; Rappuoli R; Scarlato V
Mutations in the linker region of BvgS abolish response to environmental signals for the regulation of the virulence factors in Bordetella pertussis.
Gene 1994;150(1):123-7.
1994: Rappuoli R; Covacci A; Ghiara P; Telford J
Pathogenesis of Helicobacter pylori and perspectives of vaccine development against an emerging pathogen.
Behring Institute Mitteilungen 1994;(95):42-8.
1994: Papini E; de Bernard M; Milia E; Bugnoli M; Zerial M; Rappuoli R; Montecucco C
Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9720-4.
1994: Pizza M; Domenighini M; Hol W; Giannelli V; Fontana M R; Giuliani M M; Magagnoli C; Peppoloni S; Manetti R; Rappuoli R
Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis.
Molecular microbiology 1994;14(1):51-60.
1994: Domenighini M; Magagnoli C; Pizza M; Rappuoli R
Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins.
Molecular microbiology 1994;14(1):41-50.
1994: Rappuoli R; Pizza M; Podda A; De Magistris M T; Ceccarini C; Nencioni L
Development of the new acellular recombinant pertussis vaccine.
Archives de l'Institut Pasteur de Tunis 1994;71(3-4):557-63.
1994: di Tommaso A; de Magistris M T; Bugnoli M; Marsili I; Rappuoli R; Abrignani S
Formaldehyde treatment of proteins can constrain presentation to T cells by limiting antigen processing.
Infection and immunity 1994;62(5):1830-4.
1993: Aricò B; Nuti S; Scarlato V; Rappuoli R
Adhesion of Bordetella pertussis to eukaryotic cells requires a time-dependent export and maturation of filamentous hemagglutinin.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9204-8.
1993: Papini E; de Bernard M; Bugnoli M; Milia E; Rappuoli R; Montecucco C
Cell vacuolization induced by Helicobacter pylori: inhibition by bafilomycins A1, B1, C1 and D.
FEMS microbiology letters 1993;113(2):155-9.
1993: Scarlato V; Aricò B; Rappuoli R
DNA topology affects transcriptional regulation of the pertussis toxin gene of Bordetella pertussis in Escherichia coli and in vitro.
Journal of bacteriology 1993;175(15):4764-71.
1993: Covacci A; Rappuoli R
Pertussis toxin export requires accessory genes located downstream from the pertussis toxin operon.
Molecular microbiology 1993;8(3):429-34.
1993: Scarlato V; Aricó B; Domenighini M; Rappuoli R
Environmental regulation of virulence factors in Bordetella species.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(2):99-104.
1993: Papini E; Bugnoli M; De Bernard M; Figura N; Rappuoli R; Montecucco C
Bafilomycin A1 inhibits Helicobacter pylori-induced vacuolization of HeLa cells.
Molecular microbiology 1993;7(2):323-7.
1993: Papini E; Rappuoli R; Murgia M; Montecucco C
Cell penetration of diphtheria toxin. Reduction of the interchain disulfide bridge is the rate-limiting step of translocation in the cytosol.
The Journal of biological chemistry 1993;268(3):1567-74.
1993: Olivieri R; Bugnoli M; Armellini D; Bianciardi S; Rappuoli R; Bayeli P F; Abate L; Esposito E; de Gregorio L; Aziz J
Growth of Helicobacter pylori in media containing cyclodextrins.
Journal of clinical microbiology 1993;31(1):160-2.
1993: Rappuoli R; Podda A; Giovannoni F; Nencioni L; Peragallo M; Francolini P
Absence of protective immunity against diphtheria in a large proportion of young adults.
Vaccine 1993;11(5):576-7.
1992: Rappuoli R; Pizza M; Covacci A; Bartoloni A; Nencioni L; Podda A; De Magistris M T
Recombinant acellular pertussis vaccine--from the laboratory to the clinic: improving the quality of the immune response.
FEMS microbiology immunology 1992;5(4):161-70.
1992: Rappuoli R; Aricó B; Scarlato V
Thermoregulation and reversible differentiation in Bordetella: a model for pathogenic bacteria.
Molecular microbiology 1992;6(15):2209-11.
1992: Podda A; De Luca E C; Titone L; Casadei A M; Cascio A; Peppoloni S; Volpini G; Marsili I; Nencioni L; Rappuoli R
Acellular pertussis vaccine composed of genetically inactivated pertussis toxin: safety and immunogenicity in 12- to 24- and 2- to 4-month-old children.
The Journal of pediatrics 1992;120(5):680-5.
1992: De Magistris M T; Di Tommaso A; Domenighini M; Censini S; Tagliabue A; Oksenberg J R; Steinman L; Judd A K; O'Sullivan D; Rappuoli R
Interaction of the pertussis toxin peptide containing residues 30-42 with DR1 and the T-cell receptors of 12 human T-cell clones.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2990-4.
1992: Marsili I; Pizza M; Giovannoni F; Volpini G; Bartalini M; Olivieri R; Rappuoli R; Nencioni L
Cellular pertussis vaccine containing a Bordetella pertussis strain that produces a nontoxic pertussis toxin molecule.
Infection and immunity 1992;60(3):1150-5.
1992: Rappuoli R; Pizza M; De Magistris M T; Podda A; Bugnoli M; Manetti R; Nencioni L
Development and clinical testing of an acellular pertussis vaccine containing genetically detoxified pertussis toxin.
Immunobiology 1992;184(2-3):230-9.
1992: Costantino P; Viti S; Podda A; Velmonte M A; Nencioni L; Rappuoli R
Development and phase 1 clinical testing of a conjugate vaccine against meningococcus A and C.
Vaccine 1992;10(10):691-8.
1992: Sansoni A; Rappuoli R; Viti S; Costantino P; Fanti O; Cellesi C
Immunity to Haemophilus influenzae type b on sample population from central Italy.
Vaccine 1992;10(9):627-30.
1992: Rappuoli R; Podda A; Pizza M; Covacci A; Bartoloni A; de Magistris M T; Nencioni L
Progress towards the development of new vaccines against whooping cough.
Vaccine 1992;10(14):1027-32.
1991: Nencioni L; Pizza M G; Volpini G; De Magistris M T; Giovannoni F; Rappuoli R
Properties of the B oligomer of pertussis toxin.
Infection and immunity 1991;59(12):4732-4.
1991: Scarlato V; Aricò B; Prugnola A; Rappuoli R
Sequential activation and environmental regulation of virulence genes in Bordetella pertussis.
The EMBO journal 1991;10(12):3971-5.
1991: Scarlato V; Rappuoli R
Differential response of the bvg virulence regulon of Bordetella pertussis to MgSO4 modulation.
Journal of bacteriology 1991;173(22):7401-4.
1991: Scarlato V; Prugnola A; Aricò B; Rappuoli R
The bvg-dependent promoters show similar behaviour in different Bordetella species and share sequence homologies.
Molecular microbiology 1991;5(10):2493-8.
1991: Aricò B; Scarlato V; Monack D M; Falkow S; Rappuoli R
Structural and genetic analysis of the bvg locus in Bordetella species.
Molecular microbiology 1991;5(10):2481-91.
1991: Podda A; Nencioni L; Marsili I; Peppoloni S; Volpini G; Donati D; Di Tommaso A; De Magistris M T; Rappuoli R
Phase I clinical trial of an acellular pertussis vaccine composed of genetically detoxified pertussis toxin combined with FHA and 69 kDa.
Vaccine 1991;9(10):741-5.
1991: Peppoloni S; Nencioni L; Di Tommaso A; Tagliabue A; Parronchi P; Romagnani S; Rappuoli R; De Magistris M T
Lymphokine secretion and cytotoxic activity of human CD4+ T-cell clones against Bordetella pertussis.
Infection and immunity 1991;59(10):3768-73.
1991: Di Tommaso A; Domenighini M; Bugnoli M; Tagliabue A; Rappuoli R; De Magistris M T
Identification of subregions of Bordetella pertussis filamentous hemagglutinin that stimulate human T-cell responses.
Infection and immunity 1991;59(9):3313-5.
1991: Rappuoli R; Pizza M; Podda A; De Magistris M T; Nencioni L
Towards third-generation whooping cough vaccines.
Trends in biotechnology 1991;9(7):232-8.
1991: Pizza M; Bugnoli M; Pucci P; Siciliano R; Marino G; Rappuoli R
Further analysis of the sequence of the S1 subunit of pertussis toxin.
Infection and immunity 1991;59(3):1177-9.
1991: Podda A; Vescia N; Donati D; Marsili I; Volpini G; Nencioni L; Mastroeni I; Rappuoli R; Fara G M
[A phase-I clinical trial of a new antitetanus/antidiphtheria vaccine for adults]
Annali di igiene : medicina preventiva e di comunità 1991;3(2):79-84.
1991: Papini E; Santucci A; Schiavo G; Domenighini M; Neri P; Rappuoli R; Montecucco C
Tyrosine 65 is photolabeled by 8-azidoadenine and 8-azidoadenosine at the NAD binding site of diphtheria toxin.
The Journal of biological chemistry 1991;266(4):2494-8.
1991: Nencioni L; Volpini G; Peppoloni S; Bugnoli M; De Magistris T; Marsili I; Rappuoli R
Properties of pertussis toxin mutant PT-9K/129G after formaldehyde treatment.
Infection and immunity 1991;59(2):625-30.
1991: Domenighini M; Montecucco C; Ripka W C; Rappuoli R
Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding.
Molecular microbiology 1991;5(1):23-31.
1991: Padovan E; Papini E; Rappuoli R; Montecucco C
Determination of diphtheria toxin neutralizing antibody titers with a cell protein synthesis inhibition assay.
Medical microbiology and immunology 1991;180(1):29-35.
1991: Nencioni L; Pizza M; Volpini G; Podda A; Rappuoli R
Genetic approaches to a vaccine for pertussis.
Advances in experimental medicine and biology 1991;303():119-27.
1990: Scarlato V; Prugnola A; Aricó B; Rappuoli R
Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):10067.
1990: Pizza M; Bugnoli M; Manetti R; Covacci A; Rappuoli R
The subunit S1 is important for pertussis toxin secretion.
The Journal of biological chemistry 1990;265(29):17759-63.
1990: Scarlato V; Prugnola A; Aricó B; Rappuoli R
Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6753-7.
1990: Domenighini M; Relman D; Capiau C; Falkow S; Prugnola A; Scarlato V; Rappuoli R
Genetic characterization of Bordetella pertussis filamentous haemagglutinin: a protein processed from an unusually large precursor.
Molecular microbiology 1990;4(5):787-800.
1990: Papini E; Schiavo G; Rappuoli R; Montecucco C
Histidine-21 is involved in diphtheria toxin NAD+ binding.
Toxicon : official journal of the International Society on Toxinology 1990;28(6):631-5.
1989: Gross R; Aricò B; Rappuoli R
Families of bacterial signal-transducing proteins.
Molecular microbiology 1989;3(11):1661-7.
1989: Bartoloni A; Pizza M; Tagliabue A; Rappuoli R
Engineering bacterial toxins for the development of a new vaccine against whooping cough.
Pharmacological research : the official journal of the Italian Pharmacological Society 1989;21 Suppl 2():19-25.
1989: Aricó B; Miller J F; Roy C; Stibitz S; Monack D; Falkow S; Gross R; Rappuoli R
Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6671-5.
1989: Gross R; Rappuoli R
Pertussis toxin promoter sequences involved in modulation.
Journal of bacteriology 1989;171(7):4026-30.
1989: Papini E; Schiavo G; Sandoná D; Rappuoli R; Montecucco C
Histidine 21 is at the NAD+ binding site of diphtheria toxin.
The Journal of biological chemistry 1989;264(21):12385-8.
1989: Presentini R; Perin F; Ancilli G; Nucci D; Bartoloni A; Rappuoli R; Antoni G
Studies of the antigenic structure of two cross-reacting proteins, pertussis and cholera toxins, using synthetic peptides.
Molecular immunology 1989;26(1):95-100.
1989: Gross R; Aricò B; Rappuoli R
Genetics of pertussis toxin.
Molecular microbiology 1989;3(1):119-24.
1988: Papini E; Sandoná D; Rappuoli R; Montecucco C
On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells.
The EMBO journal 1988;7(11):3353-9.
1988: Pizza M; Bartoloni A; Prugnola A; Silvestri S; Rappuoli R
Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7521-5.
1988: De Magistris M T; Romano M; Nuti S; Rappuoli R; Tagliabue A
Dissecting human T cell responses against Bordetella species.
The Journal of experimental medicine 1988;168(4):1351-62.
1988: Gross R; Rappuoli R
Positive regulation of pertussis toxin expression.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):3913-7.
1988: Rappuoli R; Perugini M; Falsen E
Molecular epidemiology of the 1984-1986 outbreak of diphtheria in Sweden.
The New England journal of medicine 1988;318(1):12-4.
1988: Tagliabue A; De Magistris M T; Rappuoli R
Human T-cell immunity against Bordetella pertussis analyzed at clonal level.
The Tokai journal of experimental and clinical medicine 1988;13 Suppl():253-7.
1988: Bartoloni A; Pizza M; Gross R; Perugini M; Arico B; Domenighini M; Rappuoli R
Engineering bacterial toxin for the development of new vaccine against pertussis.
The Tokai journal of experimental and clinical medicine 1988;13 Suppl():217-22.
1987: Papini E; Schiavo G; Tomasi M; Colombatti M; Rappuoli R; Montecucco C
Lipid interaction of diphtheria toxin and mutants with altered fragment B. 2. Hydrophobic photolabelling and cell intoxication.
European journal of biochemistry / FEBS 1987;169(3):637-44.
1987: Papini E; Colonna R; Cusinato F; Montecucco C; Tomasi M; Rappuoli R
Lipid interaction of diphtheria toxin and mutants with altered fragment B. 1. Liposome aggregation and fusion.
European journal of biochemistry / FEBS 1987;169(3):629-35.
1987: Aricò B; Gross R; Smida J; Rappuoli R
Evolutionary relationships in the genus Bordetella.
Molecular microbiology 1987;1(3):301-8.
1987: Bigio M; Rossi R; Nucci D; Antoni G; Rappuoli R; Ratti G
Conformational changes in diphtheria toxoids. Analysis with monoclonal antibodies.
FEBS letters 1987;218(2):271-6.
1987: Papini E; Colonna R; Schiavo G; Cusinato F; Tomasi M; Rappuoli R; Montecucco C
Diphtheria toxin and its mutant crm 197 differ in their interaction with lipids.
FEBS letters 1987;215(1):73-8.
1987: Nicosia A; Bartoloni A; Perugini M; Rappuoli R
Expression and immunological properties of the five subunits of pertussis toxin.
Infection and immunity 1987;55(4):963-7.
1987: Rappuoli R; Perugini M; Ratti G
DNA element of Corynebacterium diphtheriae with properties of an insertion sequence and usefulness for epidemiological studies.
Journal of bacteriology 1987;169(1):308-12.
1986: Nicosia A; Perugini M; Franzini C; Casagli M C; Borri M G; Antoni G; Almoni M; Neri P; Ratti G; Rappuoli R
Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(13):4631-5.
1986: Bigio M; Rossi R; Borri M G; Rappuoli R; Bartoloni A; Nucci D; Bartalini M; Antoni G
Production and characterization of monoclonal antibodies (Mabs) specifically reactive with the different subunits of toxin from "Bordetella pertussis".
Annali Sclavo. Collana monografica 1986;3(1-2):277-81.
1986: Presentini R; Perin F; Ancilli G; Rappuoli R; Bartoloni A; Lozzi L; Neri P; Antoni G
Antigenic recognition of pertussis and cholera toxin by the same antipeptide antibodies.
Annali Sclavo. Collana monografica 1986;3(1-2):283-8.
1986: Rappuoli R; Nicosia A; Bartoloni A; Aricò B; Perugini M
A recombinant DNA approach to the pertussis vaccine.
Annali Sclavo. Collana monografica 1986;3(1-2):183-9.
1985: Rappuoli R; Ratti G; Perugini M; Murphy J R
Detection and physical map of a omega tox+-related defective prophage in Corynebacterium diphtheriae Belfanti 1030(-)tox-.
Journal of virology 1985;54(1):194-8.

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