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Patrice Rat

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Estelle Sigward; Denis Brossard; Mélody Dutot; Jean-Michel Guigner; Nathalie MIGNET; Saleh Muhamed; Patrice Rat; Daniel Scherman; Sylvie Crauste-Manciet
Formulation and cytotoxicity evaluation of new self-emulsifying multiple W/O/W nanoemulsions.
Mélody Dutot; Isabelle Fabre; Christine Grasmick; Nicolas Martin-Brisac; Jacques Vincent; Patrice Rat
Ocular cytotoxicity evaluation of medical devices such as contact lens solutions and benefits of a rinse step in cleaning procedure.
Mélody Dutot; Roxane Fagon; Marc Hemon; Patrice Rat
Antioxidant, anti-inflammatory, and anti-senescence activities of a phlorotannin-rich natural extract from brown seaweed Ascophyllum nodosum.

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All Publications

2013: Estelle Sigward; Denis Brossard; Mélody Dutot; Jean-Michel Guigner; Nathalie MIGNET; Saleh Muhamed; Patrice Rat; Daniel Scherman; Sylvie Crauste-Manciet
Formulation and cytotoxicity evaluation of new self-emulsifying multiple W/O/W nanoemulsions.
International journal of nanomedicine 2013;8():611-25.
2013: Mélody Dutot; Isabelle Fabre; Christine Grasmick; Nicolas Martin-Brisac; Jacques Vincent; Patrice Rat
Ocular cytotoxicity evaluation of medical devices such as contact lens solutions and benefits of a rinse step in cleaning procedure.
ALTEX 2013;30(1):41-9.
2012: Mélody Dutot; Roxane Fagon; Marc Hemon; Patrice Rat
Antioxidant, anti-inflammatory, and anti-senescence activities of a phlorotannin-rich natural extract from brown seaweed Ascophyllum nodosum.
Applied biochemistry and biotechnology 2012;167(8):2234-40.
2012: Kamelia Ghazi; Uriell Deng-Pichon; Jean-Michel Warnet; Patrice Rat
Hyaluronan fragments improve wound healing on in vitro cutaneous model through P2X7 purinoreceptor basal activation: role of molecular weight.
PloS one 2012;7(11):e48351.
2011: Mélody Dutot; Roxane Fagon; Violaine de la Tourrette; Patrice Rat
New approach to modulate retinal cellular toxic effects of high glucose using marine epa and dha.
Nutrition & metabolism 2011;8():39.
2010: Mélody Dutot; Elisa Reveneau; Thierry Pauloin; Roxane Fagon; Caroline Tanter; Jean-Michel Warnet; Patrice Rat
Multipurpose solutions and contact lens: modulation of cytotoxicity and apoptosis on the ocular surface.
Cornea 2010;29(5):541-9.
2009: Thierry Pauloin; Mélody Dutot; Hong Liang; Emilie Chavinier; Jean-Michel Warnet; Patrice Rat
Corneal protection with high-molecular-weight hyaluronan against in vitro and in vivo sodium lauryl sulfate-induced toxic effects.
Cornea 2009;28(9):1032-41.
2009: Mélody Dutot; Hong Liang; Chantal Martin; Delphine Rousseau; Alain Grynberg; Jean-Michel Warnet; Patrice Rat
Per os administered refined olive oil and marine PUFA-rich oils reach the cornea: possible role on oxidative stress through caveolin-1 modulation.
Nutrition & metabolism 2009;6():48.
2009: Thierry Pauloin; Mélody Dutot; Francine Joly; Jean-Michel Warnet; Patrice Rat
High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells.
Molecular vision 2009;15():577-83.
2009: Toihiri Said; Mélody Dutot; Antoine Labbé; Jean-Michel Warnet; Patrice Rat
Ocular burn: rinsing and healing with ionic marine solutions and vegetable oils.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde 2009;223(1):52-9.
2008: Thierry Pauloin; Mélody Dutot; Jean-Michel Warnet; Patrice Rat
In vitro modulation of preservative toxicity: high molecular weight hyaluronan decreases apoptosis and oxidative stress induced by benzalkonium chloride.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;34(4-5):263-73.
2008: Mélody Dutot; Jean-Michel Warnet; Christophe Baudouin; Patrice Rat
Cytotoxicity of contact lens multipurpose solutions: role of oxidative stress, mitochondrial activity and P2X7 cell death receptor activation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;33(2):138-45.
2008: Mélody Dutot; Hong Liang; Thierry Pauloin; Françoise Brignole-Baudouin; Christophe Baudouin; Jean-Michel Warnet; Patrice Rat
Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor.
Molecular vision 2008;14():889-97.
2007: M J M Ezoulin; Z Liu; Hélène Dutertre-Catella; G Wu; Chang-Zhi Dong; Françoise Heymans; Jean-Edouard Ombetta; Patrice Rat; France Massicot
A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine.
International immunopharmacology 2007;7(13):1685-94.
2007: Toihiri Said; Mélody Dutot; Raymond Christon; Jean-Louis Beaudeux; Chantal Martin; Jean-Michel Warnet; Patrice Rat
Benefits and side effects of different vegetable oil vectors on apoptosis, oxidative stress, and P2X7 cell death receptor activation.
Investigative ophthalmology & visual science 2007;48(11):5000-6.
2007: Aude Pauly; Françoise Brignole-Baudouin; Jean-Marc Guenoun; Luisa Riancho; Patrice Rat; Jean-Michel Warnet; Christophe Baudouin
Comparative study of topical anti-allergic eye drops on human conjunctiva-derived cells: responses to histamine and IFN gamma and toxicological profiles.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2007;245(4):534-46.
2007: Toihiri Said; Mélody Dutot; Chantal Martin; Jean-Louis Beaudeux; C Boucher; E Enee; Christophe Baudouin; Jean-Michel Warnet; Patrice Rat
Cytoprotective effect against UV-induced DNA damage and oxidative stress: role of new biological UV filter.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2007;30(3-4):203-10.
2006: A Staropoli; Christophe Baudouin; Mélody Dutot; G Sultan; Jean-Michel Warnet; Patrice Rat
[Role of conditioning medium cytotoxicity. An example with an intraocular lens preloaded in injector].
Journal français d'ophtalmologie 2006;29(7):773-80.
2006: Mélody Dutot; François Pouzaud; Isabelle Larosche; Françoise Brignole-Baudouin; Jean-Michel Warnet; Patrice Rat
Fluoroquinolone eye drop-induced cytotoxicity: role of preservative in P2X7 cell death receptor activation and apoptosis.
Investigative ophthalmology & visual science 2006;47(7):2812-9.
2006: François Pouzaud; Mélody Dutot; Chantal Martin; M Debray; Jean-Michel Warnet; Patrice Rat
Age-dependent effects on redox status, oxidative stress, mitochondrial activity and toxicity induced by fluoroquinolones on primary cultures of rabbit tendon cells.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2006;143(2):232-41.
2006: H Nourry; Sébastien Perrot; Chantal Martin; Christine Chaumeil; C Cambourieu; Patrice Rat; Jean-Michel Warnet
[Cytotoxicity evaluation of different eyes drops with cyclosporine oral solution (Sandimmun)].
Journal français d'ophtalmologie 2006;29(3):251-7.
2005: Jean-Marc Guenoun; Christophe Baudouin; Patrice Rat; Aude Pauly; Jean-Michel Warnet; Françoise Brignole-Baudouin
In vitro comparison of cytoprotective and antioxidative effects of latanoprost, travoprost, and bimatoprost on conjunctiva-derived epithelial cells.
Investigative ophthalmology & visual science 2005;46(12):4594-9.
2005: Jean-Marc Guenoun; Christophe Baudouin; Patrice Rat; Aude Pauly; Jean-Michel Warnet; Françoise Brignole-Baudouin
In vitro study of inflammatory potential and toxicity profile of latanoprost, travoprost, and bimatoprost in conjunctiva-derived epithelial cells.
Investigative ophthalmology & visual science 2005;46(7):2444-50.
2004: François Pouzaud; M-O Christen; Jean-Michel Warnet; Patrice Rat
[Anethole dithiolethione: an antioxidant agent against tenotoxicity induced by fluoroquinolones].
Pathologie-biologie 2004;52(6):308-13.
2004: Pierre-Jean Pisella; Caroline Debbasch; Pascale Hamard; Catherine Creuzot-Garcher; Patrice Rat; Françoise Brignole; Christophe Baudouin
Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: an ex vivo and in vitro study.
Investigative ophthalmology & visual science 2004;45(5):1360-8.
2004: François Pouzaud; K Bernard-Beaubois; Marc Thevenin; Jean-Michel Warnet; G Hayem; Patrice Rat
In vitro discrimination of fluoroquinolones toxicity on tendon cells: involvement of oxidative stress.
The Journal of pharmacology and experimental therapeutics 2004;308(1):394-402.
2003: Sébastien Perrot; Hélène Dutertre-Catella; Chantal Martin; Jean-Michel Warnet; Patrice Rat
A new nondestructive cytometric assay based on resazurin metabolism and an organ culture model for the assessment of corneal viability.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;55(1):7-14.
2003: Chantal Martin; Hélène Dutertre-Catella; Martine Radionoff; M Debray; C Benstaali; Patrice Rat; Marc Thevenin; Yvan Touitou; Jean-Michel Warnet
Effect of age and photoperiodic conditions on metabolism and oxidative stress related markers at different circadian stages in rat liver and kidney.
Life sciences 2003;73(3):327-35.
2003: Sébastien Perrot; Hélène Dutertre-Catella; Chantal Martin; Patrice Rat; Jean-Michel Warnet
Resazurin metabolism assay is a new sensitive alternative test in isolated pig cornea.
Toxicological sciences : an official journal of the Society of Toxicology 2003;72(1):122-9.
2002: François Pouzaud; Patrice Rat; C Cambourieu; H Nourry; Jean-Michel Warnet
[Tenotoxic potential of fluoroquinolones in the choice of surgical antibiotic prophylaxis in ophthalmology].
Journal français d'ophtalmologie 2002;25(9):921-6.
2002: Caroline Debbasch; Stéphanie Bruneau De La Salle; Françoise Brignole; Patrice Rat; Jean-Michel Warnet; Christophe Baudouin
Cytoprotective effects of hyaluronic acid and Carbomer 934P in ocular surface epithelial cells.
Investigative ophthalmology & visual science 2002;43(11):3409-15.
2002: François Auclin; Patrice Rat; E Tuil; C Boureau-Andrieux; Christophe Morel; Olivier Laplace; C Cambourieu; S Limon; Jean-Philippe Nordmann; Laurent Laroche; Christophe Baudouin
[Clinical evaluation of the ocular safety of Amukine 0.06% solution for local application versus povidone iodine (Bétadine) 5% solution for ocular irrigation) in preoperative antisepsis].
Journal français d'ophtalmologie 2002;25(2):120-5.
2001: Pierre-Jean Pisella; Florence Malet; Sophie Lejeune; Françoise Brignole; Caroline Debbasch; Jacques Bara; Patrice Rat; Joseph Colin; Christophe Baudouin
Ocular surface changes induced by contact lens wear.
Cornea 2001;20(8):820-5.
2001: Caroline Debbasch; Pierre-Jean Pisella; Magdalena De Saint Jean; Patrice Rat; Jean-Michel Warnet; Christophe Baudouin
Mitochondrial activity and glutathione injury in apoptosis induced by unpreserved and preserved beta-blockers on Chang conjunctival cells.
Investigative ophthalmology & visual science 2001;42(11):2525-33.
2001: Yazid Belkacémi; Emmanuel Touboul; J B Méric; Patrice Rat; Jean-Michel Warnet
[Radiation-induced cataract: physiopathologic, radiobiologic and clinical aspects].
Cancer radiothérapie : journal de la Société française de radiothérapie oncologique 2001;5(4):397-412.
2001: Caroline Debbasch; Françoise Brignole; Pierre-Jean Pisella; Jean-Michel Warnet; Patrice Rat; Christophe Baudouin
Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells.
Investigative ophthalmology & visual science 2001;42(3):642-52.
2001: Caroline Debbasch; Pierre-Jean Pisella; Patrice Rat; Jean-Michel Warnet; Christophe Baudouin
[Antioxidant effects of mast cell inhibitors in a human conjunctival cell line].
Journal français d'ophtalmologie 2001;24(2):121-8.
2001: Yazid Belkacémi; Patrice Rat; Gaëlle Piel; M O Christen; Emmanuel Touboul; Jean-Michel Warnet
Lens epithelial cell protection by aminothiol WR-1065 and anetholedithiolethione from ionizing radiation.
International journal of cancer. Journal international du cancer 2001;96 Suppl():15-26.
2000: R A Osseni; Patrice Rat; A Bogdan; Jean-Michel Warnet; Yvan Touitou
Evidence of prooxidant and antioxidant action of melatonin on human liver cell line HepG2.
Life sciences 2000;68(4):387-99.
2000: Caroline Debbasch; Pierre-Jean Pisella; Patrice Rat; Jean-Michel Warnet; Christophe Baudouin
[Cytotoxicity evaluation of three tear substitutes used in the treatment of dry eye syndromes].
Journal français d'ophtalmologie 2000;23(9):863-9.
2000: Yazid Belkacémi; Gaëlle Piel; Patrice Rat; F Julia; Emmanuel Touboul; Martin Housset; Jean-Michel Warnet
Ionizing radiation-induced death in bovine lens epithelial cells: mechanisms and influence of irradiation dose rate.
International journal of cancer. Journal international du cancer 2000;90(3):138-44.
2000: Caroline Debbasch; Pierre-Jean Pisella; Patrice Rat; Jean-Michel Warnet; Christophe Baudouin
[Evaluation of free radical production by conjunctival impression cytology of patients treated with long-term antiglaucoma drugs or of contact lens wearers].
Journal français d'ophtalmologie 2000;23(3):239-44.
2000: Magdalena De Saint Jean; Caroline Debbasch; Françoise Brignole; Patrice Rat; Jean-Michel Warnet; Christophe Baudouin
[Toxicity of preserved and unpreserved beta-blocker eyedrops in an in vitro model of human conjunctival cells].
Journal français d'ophtalmologie 2000;23(2):111-21.
2000: Magdalena De Saint Jean; Caroline Debbasch; Françoise Brignole; Patrice Rat; Jean-Michel Warnet; Christophe Baudouin
Toxicity of preserved and unpreserved antiglaucoma topical drugs in an in vitro model of conjunctival cells.
Current eye research 2000;20(2):85-94.
1999: Caroline Debbasch; Magdalena De Saint Jean; Pierre-Jean Pisella; Patrice Rat; Jean-Michel Warnet; Christophe Baudouin
[Quaternary ammonium cytotoxicity in a human conjunctival cell line].
Journal français d'ophtalmologie 1999;22(9):950-8.
1998: K Bernard-Beaubois; C Hecquet; G Hayem; Patrice Rat; M Adolphe
In vitro study of cytotoxicity of quinolones on rabbit tenocytes.
Cell biology and toxicology 1998;14(4):283-92.