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Pradipsinh Rathod

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Thurston Herricks; Malcolm Molyneux; Karl Boynton Seydel; Terrie Taylor; Pradipsinh K Rathod
Estimating physical splenic filtration of Plasmodium falciparum-infected red blood cells in malaria patients.
Alka Marwaha; Margaret A Phillips; John White; Frederick S Buckner; Susan A Charman; Sharon A Creason; Farah El Mazouni; Sreekanth Kokkonda; Pradipsinh K Rathod
Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase.
Krishnamoorthy Narayanasamy; Janneth Rodrigues; Bikram Roy; Somdutta Sen; Jayanthi Shastri; Joseph Smith; Neena Valecha; John White; Analabha Basu; Laura Chery; Manoj T Duraisingh; Ananias Escalante; Joseph Fowble; Jennifer L Guler; Thurston Herricks; Ashwani Kumar; Partha Majumder; Jennifer Maki; Anjali Mascarenhas; Pradipsinh K Rathod
Malaria evolution in South Asia: knowledge for control and elimination.

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All Publications

2012: Thurston Herricks; Malcolm Molyneux; Karl Boynton Seydel; Terrie Taylor; Pradipsinh K Rathod
Estimating physical splenic filtration of Plasmodium falciparum-infected red blood cells in malaria patients.
Cellular microbiology 2012;14(12):1880-91.
2012: Alka Marwaha; Margaret A Phillips; John White; Frederick S Buckner; Susan A Charman; Sharon A Creason; Farah El Mazouni; Sreekanth Kokkonda; Pradipsinh K Rathod
Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase.
Journal of medicinal chemistry 2012;55(17):7425-36.
2012: Krishnamoorthy Narayanasamy; Janneth Rodrigues; Bikram Roy; Somdutta Sen; Jayanthi Shastri; Joseph Smith; Neena Valecha; John White; Analabha Basu; Laura Chery; Manoj T Duraisingh; Ananias Escalante; Joseph Fowble; Jennifer L Guler; Thurston Herricks; Ashwani Kumar; Partha Majumder; Jennifer Maki; Anjali Mascarenhas; Pradipsinh K Rathod
Malaria evolution in South Asia: knowledge for control and elimination.
Acta tropica 2012;121(3):256-66.
2012: Ashwani Kumar; Satish N Mahajan; Ardhendu Maji; Partha Majumder; Jagadish Mohanta; Pradyumna K Mohapatra; Krishnamoorthy Narayanasamy; Chinmoy Biswas; Laura Chery; Virendra Kumar Dua; Nagesh Dubhashi; Prafulla Dutta; Mridula Kacchap; Sanjeeb Kakati; Anar Khandeparkar; Dalip Kour; Krishnangshu Roy; Jayanthi Shastri; Neena Valecha; Rana Vikash; Reena Wani; John White; Pradipsinh K Rathod
Malaria in South Asia: prevalence and control.
Acta tropica 2012;121(3):246-55.
2011: Thurston Herricks; Robert Heyderman; Malcolm Molyneux; Karl Boynton Seydel; Terrie E Taylor; George Turner; Pradipsinh K Rathod
A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells.
Lab on a chip 2011;11(17):2994-3000.
2011: Jose M Coteron; Xiaoyi Deng; Farah El Mazouni; Jorge Esquivias; Santiago B Ferrer; David Floyd; Francisco-Javier Gamo; Elizabeth J Goldsmith; María Belén Jiménez-Díaz; Kasiram Katneni; Sreekanth Kokkonda; Maria Koltun; María Marco; David Matthews; Iñigo Angulo-Barturen; Ian Bathurst; Ravi Bhamidipati; Jeremy N Burrows; Susan A Charman; William N Charman; Pradipsinh K Rathod; David M Shackleford; John White; Karen L White; Margaret A Phillips
Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.
Journal of medicinal chemistry 2011;54(15):5540-61.
2011: Ramesh Gujjar; Farah El Mazouni; Karen L White; John White; Sharon Creason; David M Shackleford; Xiaoyi Deng; William N Charman; Ian Bathurst; Jeremy Burrows; David M Floyd; David Matthews; Frederick S Buckner; Susan A Charman; Margaret A Phillips; Pradipsinh K Rathod
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.
Journal of medicinal chemistry 2011;54(11):3935-49.
2011: Suresh M Ganesan; Joanne M Morrisey; Hangjun Ke; Heather J Painter; Kamal Laroiya; Margaret A Phillips; Pradipsinh K Rathod; Michael W Mather; Akhil B Vaidya
Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.
Molecular and biochemical parasitology 2011;177(1):29-34.
2011: Ashwani Kumar; Virendra Kumar Dua; Pradipsinh K Rathod
Malaria-attributed death rates in India.
Lancet 2011;377(9770):991-2; author reply 994-5.
2010: Margaret A Phillips; Pradipsinh K Rathod
Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.
Infectious disorders drug targets 2010;10(3):226-39.
2010: Xin E Sun; Lisa Sharling; Mani Muthalagi; Devaraja G Mudeppa; Krzysztof W Pankiewicz; Krzysztof Felczak; Pradipsinh K Rathod; Jan R Mead; Boris Striepen; Lizbeth Hedstrom
Prodrug activation by Cryptosporidium thymidine kinase.
The Journal of biological chemistry 2010;285(21):15916-22.
2010: Eric T Larson; Devaraja G Mudeppa; John R Gillespie; Natascha Mueller; Alberto J Napuli; Jennifer A Arif; Jenni Ross; Tracy L Arakaki; Angela Lauricella; George deTitta; Joseph Luft; Frank Zucker; Christophe Verlinde; Erkang Fan; Wesley C Van Voorhis; Frederick S Buckner; Pradipsinh K Rathod; Wim G J Hol; Ethan A Merritt
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
Journal of molecular biology 2010;396(5):1244-59.
2009: Cullen K T Pang; Joshua H Hunter; Ramesh Gujjar; Ramulu Podutoori; Julie Bowman; Mudeppa Devaraja; Pradipsinh K Rathod
Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase.
Molecular and biochemical parasitology 2009;168(1):74-83.
2009: Xiaoyi Deng; Ramesh Gujjar; Farah El Mazouni; Werner Kaminsky; Nicholas A Malmquist; Elizabeth J Goldsmith; Pradipsinh K Rathod; Margaret A Phillips
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
The Journal of biological chemistry 2009;284(39):26999-7009.
2009: Thurston Herricks; Meher Antia; Pradipsinh K Rathod
Deformability limits of Plasmodium falciparum-infected red blood cells.
Cellular microbiology 2009;11(9):1340-53.
2009: Ramesh Gujjar; Alka Marwaha; Farah El Mazouni; John White; Karen L White; Sharon Creason; David M Shackleford; Jeffrey Baldwin; William N Charman; Frederick S Buckner; Susan Charman; Pradipsinh K Rathod; Margaret A Phillips
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.
Journal of medicinal chemistry 2009;52(7):1864-72.
2008: Karthikeyan Ganesan; Napawan Ponmee; Lei Jiang; Joseph W Fowble; John White; Sumalee Kamchonwongpaisan; Yongyuth Yuthavong; Prapon Wilairat; Pradipsinh K Rathod
A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates.
PLoS pathogens 2008;4(11):e1000214.
2008: Meher Antia; Thurston Herricks; Pradipsinh K Rathod
Microfluidic approaches to malaria pathogenesis.
Cellular microbiology 2008;10(10):1968-74.
2008: Joseph M Gonzales; Jigar J Patel; Napawan Ponmee; Lei Jiang; Asako Tan; Steven P Maher; Stefan Wuchty; Pradipsinh K Rathod; Michael T Ferdig
Regulatory hotspots in the malaria parasite genome dictate transcriptional variation.
PLoS biology 2008;6(9):e238.
2008: Long Cui; Jun Miao; Tetsuya Furuya; Qi Fan; Xinyi Li; Pradipsinh K Rathod; Xin-zhuan Su; Liwang Cui
Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development.
Eukaryotic cell 2008;7(7):1200-10.
2008: Margaret A Phillips; Ramesh Gujjar; Nicholas A Malmquist; John White; Farah El Mazouni; Jeffrey Baldwin; Pradipsinh K Rathod
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.
Journal of medicinal chemistry 2008;51(12):3649-53.
2008: Nicholas A Malmquist; Ramesh Gujjar; Pradipsinh K Rathod; Margaret A Phillips
Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase.
Biochemistry 2008;47(8):2466-75.
2008: Joshua H Hunter; Ramesh Gujjar; Cullen K T Pang; Pradipsinh K Rathod
Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX.
PloS one 2008;3(5):e2237.
2008: Ernest J Mui; Guy A Schiehser; Wilbur K Milhous; Honghue Hsu; Craig William Roberts; Michael J Kirisits; Stephen P Muench; David Rice; J P Dubey; Joseph W Fowble; Pradipsinh K Rathod; Sherry F Queener; Susan R Liu; David P Jacobus; Rima McLeod
Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo.
PLoS neglected tropical diseases 2008;2(3):e190.
2007: Meher Antia; Thurston Herricks; Pradipsinh K Rathod
Microfluidic modeling of cell-cell interactions in malaria pathogenesis.
PLoS pathogens 2007;3(7):e99.
2007: Richard Eastman; John White; Oliver Hucke; Kohei Yokoyama; Christophe Verlinde; Michael A Hast; Lorena S Beese; Michael H Gelb; Pradipsinh K Rathod; Wesley C Van Voorhis
Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.
Molecular and biochemical parasitology 2007;152(1):66-71.
2007: Mudeppa Devaraja; Cullen K T Pang; Takafumi Tsuboi; Yaeta Endo; Frederick S Buckner; Gabriele Varani; Pradipsinh K Rathod
Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.
Molecular and biochemical parasitology 2007;151(2):216-9.
2005: Cullen K T Pang; Surya De; John White; Frederick S Buckner; Gabriele Varani; Pradipsinh K Rathod
Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase.
Molecular and biochemical parasitology 2005;143(1):121-4.
2005: Jeffrey Baldwin; Carolyn H Michnoff; Nicholas A Malmquist; John White; Michael Roth; Pradipsinh K Rathod; Margaret A Phillips
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
The Journal of biological chemistry 2005;280(23):21847-53.
2005: Richard Eastman; John White; Oliver Hucke; Kevin Bauer; Kohei Yokoyama; Laxman Nallan; Debopam Chakrabarti; Christophe Verlinde; Michael H Gelb; Pradipsinh K Rathod; Wesley C Van Voorhis
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
The Journal of biological chemistry 2005;280(14):13554-9.
2003: J Patrick Shelby; John White; Karthikeyan Ganesan; Pradipsinh K Rathod; Daniel T Chiu
A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14618-22.
2003: Pradipsinh K Rathod; Margaret A Phillips
Prized malaria drug target nailed.
Nature structural biology 2003;10(5):316-8.
2002: Karthikeyan Ganesan; Lei Jiang; Pradipsinh K Rathod
Stochastic versus stable transcriptional differences on Plasmodium falciparum DNA microarrays.
International journal for parasitology 2002;32(13):1543-50.
2002: Jeffrey Baldwin; Azizeh M Farajallah; Nicholas A Malmquist; Pradipsinh K Rathod; Margaret A Phillips
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
The Journal of biological chemistry 2002;277(44):41827-34.
2002: Kai Zhang; Pradipsinh K Rathod
Divergent regulation of dihydrofolate reductase between malaria parasite and human host.
Science (New York, N.Y.) 2002;296(5567):545-7.
2002: Pradipsinh K Rathod; Karthikeyan Ganesan; Rhian E Hayward; Zbynek Bozdech; Joe L DeRisi
DNA microarrays for malaria.
Trends in parasitology 2002;18(1):39-45.
2000: S Alfadhli; Pradipsinh K Rathod
Gene organization of a Plasmodium falciparum serine hydroxymethyltransferase and its functional expression in Escherichia coli.
Molecular and biochemical parasitology 2000;110(2):283-91.
2000: L Jiang; PC Lee; J White; Pradipsinh K Rathod
Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2000;44(4):1047-50.
2000: R E Hayward; Joe L DeRisi; S Alfadhli; D C Kaslow; P O Brown; Pradipsinh K Rathod
Shotgun DNA microarrays and stage-specific gene expression in Plasmodium falciparum malaria.
Molecular microbiology 2000;35(1):6-14.
1999: S Shallom; K Zhang; L Jiang; Pradipsinh K Rathod
Essential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains.
The Journal of biological chemistry 1999;274(53):37781-6.
1997: M Hekmat-Nejad; Pradipsinh K Rathod
Plasmodium falciparum: kinetic interactions of WR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase.
Experimental parasitology 1997;87(3):222-8.
1997: Pradipsinh K Rathod; T McErlean; PC Lee
Variations in frequencies of drug resistance in Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9389-93.
1997: M Hekmat-Nejad; PC Lee; Pradipsinh K Rathod
Plasmodium falciparum: direct cloning and expression of pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase domains.
Experimental parasitology 1997;85(3):303-5.
1996: M Hekmat-Nejad; Pradipsinh K Rathod
Kinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694.
Antimicrobial agents and chemotherapy 1996;40(7):1628-32.
1996: S Gassis; Pradipsinh K Rathod
Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance.
Antimicrobial agents and chemotherapy 1996;40(4):914-9.
1994: Pradipsinh K Rathod; M Khosla; S Gassis; R D Young; C Lutz
Selection and characterization of 5-fluoroorotate-resistant Plasmodium falciparum.
Antimicrobial agents and chemotherapy 1994;38(12):2871-6.
1994: P J Leonard; Pradipsinh K Rathod; J Golin
Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux.
Antimicrobial agents and chemotherapy 1994;38(10):2492-4.
1994: Pradipsinh K Rathod; S Reshmi
Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase.
Antimicrobial agents and chemotherapy 1994;38(3):476-80.
1993: R D Young; Pradipsinh K Rathod
Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate.
Antimicrobial agents and chemotherapy 1993;37(5):1102-7.
1992: Pradipsinh K Rathod; N P Leffers; R D Young
Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum.
Antimicrobial agents and chemotherapy 1992;36(4):704-11.
1991: Pradipsinh K Rathod; Z M Gomez
Plasmodium yoelii: oral delivery of 5-fluoroorotate to treat malaria in mice.
Experimental parasitology 1991;73(4):512-4.
1990: Pradipsinh K Rathod; A Khatri
Synthesis and antiproliferative activity of threo-5-fluoro-L-dihydroorotate.
The Journal of biological chemistry 1990;265(24):14242-9.
1990: Z M Gómez; Pradipsinh K Rathod
Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice.
Antimicrobial agents and chemotherapy 1990;34(7):1371-5.
1989: Pradipsinh K Rathod; A Khatri; T Hubbert; W K Milhous
Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
Antimicrobial agents and chemotherapy 1989;33(7):1090-4.