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Boris Ratnikov

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Living Beings

West Nile virus

Anatomy

Tumor Cells, Cultured

Physiology

Phenomena

Protein Binding

Co-author Network

Publications

TOP 3
Vladislav Golubkov; Piotr Cieplak; Alexei V Chekanov; Boris I Ratnikov; Alexander E Aleshin; Natalya V Golubkova; Tatiana I Postnova; Ilian A Radichev; Dmitri V Rozanov; Wenhong Zhu; Khatereh Motamedchaboki; Alex Y Strongin
Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.
Sergey A Shiryaev; Ilian A Radichev; Boris I Ratnikov; Alexander E Aleshin; Katarzyna Gawlik; Boguslaw Stec; Christian Frisch; Achim Knappik; Alex Y Strongin
Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus.
Sergey A Shiryaev; Albert G Remacle; Alexei Y Savinov; Andrei V Chernov; Piotr Cieplak; Ilian A Radichev; Roy Williams; Tatiana N Shiryaeva; Katarzyna Gawlik; Tatiana I Postnova; Boris I Ratnikov; Alexey Eroshkin; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis.

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All Publications

2010: Vladislav Golubkov; Piotr Cieplak; Alexei V Chekanov; Boris I Ratnikov; Alexander E Aleshin; Natalya V Golubkova; Tatiana I Postnova; Ilian A Radichev; Dmitri V Rozanov; Wenhong Zhu; Khatereh Motamedchaboki; Alex Y Strongin
Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.
The Journal of biological chemistry 2010;285(36):27726-36.
2010: Sergey A Shiryaev; Ilian A Radichev; Boris I Ratnikov; Alexander E Aleshin; Katarzyna Gawlik; Boguslaw Stec; Christian Frisch; Achim Knappik; Alex Y Strongin
Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus.
The Biochemical journal 2010;427(3):369-76.
2009: Sergey A Shiryaev; Albert G Remacle; Alexei Y Savinov; Andrei V Chernov; Piotr Cieplak; Ilian A Radichev; Roy Williams; Tatiana N Shiryaeva; Katarzyna Gawlik; Tatiana I Postnova; Boris I Ratnikov; Alexey Eroshkin; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis.
The Journal of biological chemistry 2009;284(44):30615-26.
2009: Sergey A Shiryaev; Alexei Y Savinov; Piotr Cieplak; Boris I Ratnikov; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis.
PloS one 2009;4(3):e4952.
2008: Albert G Remacle; Sergey A Shiryaev; Eok-Soo Oh; Piotr Cieplak; Anupama Srinivasan; Ge Wei; Robert C Liddington; Boris I Ratnikov; Amelie Parent; Roxane Desjardins; Robert Day; Jeffrey W Smith; Michal Lebl; Alex Y Strongin
Substrate cleavage analysis of furin and related proprotein convertases. A comparative study.
The Journal of biological chemistry 2008;283(30):20897-906.
2008: Andrei V Chernov; Sergey A Shiryaev; Alexander E Aleshin; Boris I Ratnikov; Jeffrey W Smith; Robert C Liddington; Alex Y Strongin
The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.
The Journal of biological chemistry 2008;283(25):17270-8.
2008: Ilian Radichev; Sergey A Shiryaev; Alexander E Aleshin; Boris I Ratnikov; Jeffrey W Smith; Robert C Liddington; Alex Y Strongin
Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase.
The Journal of general virology 2008;89(Pt 3):636-41.
2007: Vladislav Golubkov; Alexei V Chekanov; Sergey A Shiryaev; Alexander E Aleshin; Boris I Ratnikov; Katarzyna Gawlik; Ilian Radichev; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.
The Journal of biological chemistry 2007;282(50):36283-91.
2007: Paul A Johnston; Jennifer Phillips; Tong Ying Shun; Sunita Shinde; John Lazo; Donna M Huryn; Michael C Myers; Boris I Ratnikov; Jeffrey W Smith; Ying Su; Russell Dahl; Nicholas Cosford; Sergey A Shiryaev; Alex Y Strongin
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus.
Assay and drug development technologies 2007;5(6):737-50.
2007: Sergey A Shiryaev; Albert G Remacle; Boris I Ratnikov; Nicholas A Nelson; Alexei Y Savinov; Ge Wei; Massimo Bottini; Michele F Rega; Amelie Parent; Roxane Desjardins; Martin Fugere; Robert Day; Mojgan Sabet; Maurizio Pellecchia; Robert C Liddington; Jeffrey W Smith; Tomas Mustelin; Donald G Guiney; Michal Lebl; Alex Y Strongin
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
The Journal of biological chemistry 2007;282(29):20847-53.
2007: Sergey A Shiryaev; Boris I Ratnikov; Alexander E Aleshin; Igor A Kozlov; Nicholas A Nelson; Michal Lebl; Jeffrey W Smith; Robert C Liddington; Alex Y Strongin
Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis.
Journal of virology 2007;81(9):4501-9.
2007: Sergey A Shiryaev; Alexander E Aleshin; Boris I Ratnikov; Jeffrey W Smith; Robert C Liddington; Alex Y Strongin
Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region.
Protein expression and purification 2007;52(2):334-9.
2007: Sergey A Shiryaev; Igor A Kozlov; Boris I Ratnikov; Jeffrey W Smith; Michal Lebl; Alex Y Strongin
Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses.
The Biochemical journal 2007;401(3):743-52.
2006: Sergey A Shiryaev; Boris I Ratnikov; Alexei V Chekanov; Sergey Sikora; Dmitri V Rozanov; Adam Godzik; Jun Wang; Jeffrey W Smith; Ziwei Huang; Iris Lindberg; Melanie A Samuel; Michael S Diamond; Alex Y Strongin
Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase.
The Biochemical journal 2006;393(Pt 2):503-11.
2004: Nahum Meller; Mohammad Irani-Tehrani; Boris I Ratnikov; Bryce M Paschal; Martin A Schwartz
The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain.
The Journal of biological chemistry 2004;279(36):37470-6.
2004: Elena I Deryugina; Boris I Ratnikov; Qing Yu; Peter C Baciu; Dmitri V Rozanov; Alex Y Strongin
Prointegrin maturation follows rapid trafficking and processing of MT1-MMP in Furin-Negative Colon Carcinoma LoVo Cells.
Traffic (Copenhagen, Denmark) 2004;5(8):627-41.
2003: Elena I Deryugina; Boris I Ratnikov; Alex Y Strongin
Prinomastat, a hydroxamate inhibitor of matrix metalloproteinases, has a complex effect on migration of breast carcinoma cells.
International journal of cancer. Journal international du cancer 2003;104(5):533-41.
2002: Boris I Ratnikov; Elena I Deryugina; Alex Y Strongin
Gelatin zymography and substrate cleavage assays of matrix metalloproteinase-2 in breast carcinoma cells overexpressing membrane type-1 matrix metalloproteinase.
Laboratory investigation; a journal of technical methods and pathology 2002;82(11):1583-90.
2002: Dmitri V Rozanov; Berhane Ghebrehiwet; Boris I Ratnikov; Edward Monosov; Elena I Deryugina; Alex Y Strongin
The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein.
FEBS letters 2002;527(1-3):51-7.
2002: Steven J Kridel; Hisako Sawai; Boris I Ratnikov; Emily I Chen; Weizhong Li; Adam Godzik; Alex Y Strongin; Jeffrey W Smith
A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases.
The Journal of biological chemistry 2002;277(26):23788-93.
2002: Elena I Deryugina; Boris I Ratnikov; Tatiana I Postnova; Dmitri V Rozanov; Alex Y Strongin
Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase.
The Journal of biological chemistry 2002;277(12):9749-56.
2002: Boris I Ratnikov; Dmitri V Rozanov; Tatiana I Postnova; Peter G Baciu; Heying Zhang; Richard G DiScipio; Galina G Chestukhina; Jeffrey W Smith; Elena I Deryugina; Alex Y Strongin
An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase.
The Journal of biological chemistry 2002;277(9):7377-85.
2001: Dmitri V Rozanov; Elena I Deryugina; Boris I Ratnikov; Edward Monosov; George N Marchenko; James P Quigley; Alex Y Strongin
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells.
The Journal of biological chemistry 2001;276(28):25705-14.
2001: George N Marchenko; Boris I Ratnikov; Dmitri V Rozanov; Adam Godzik; Elena I Deryugina; Alex Y Strongin
Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin.
The Biochemical journal 2001;356(Pt 3):705-18.
2001: Alexey M Belkin; Sergey S Akimov; L S Zaritskaya; Boris I Ratnikov; Elena I Deryugina; Alex Y Strongin
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion.
The Journal of biological chemistry 2001;276(21):18415-22.
2001: Elena I Deryugina; Boris I Ratnikov; Edward Monosov; Tatiana I Postnova; Richard G DiScipio; Jeffrey W Smith; Alex Y Strongin
MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells.
Experimental cell research 2001;263(2):209-23.
1997: EC Lin; Boris I Ratnikov; P M Tsai; CP Carron; D M Myers; C F Barbas; Jeffrey W Smith
Identification of a region in the integrin beta3 subunit that confers ligand binding specificity.
The Journal of biological chemistry 1997;272(38):23912-20.
1997: EC Lin; Boris I Ratnikov; P M Tsai; E R Gonzalez; S McDonald; A J Pelletier; Jeffrey W Smith
Evidence that the integrin beta3 and beta5 subunits contain a metal ion-dependent adhesion site-like motif but lack an I domain.
The Journal of biological chemistry 1997;272(22):14236-43.